CN104666722A - Traditional Chinese medicine for treating menstrual disorder - Google Patents

Abstract

The invention relates to a traditional Chinese medicine for treating menstrual disorder. The traditional Chinese medicine is prepared from the following active pharmaceutical ingredients in parts by weight: 12 parts of Chinese angelica, 12 parts of red paeony root, 10 parts of radix rehmanniae preparata, 10 parts of tree peony bark, 12 parts of baical skullcap root, 10 parts of cape jasmine fruits, 10 parts of green tangerine peel and 10 parts of nutgrass galingale rhizome. Clinical experiments prove that the traditional Chinese medicine provided by the invention can safely and effectively treat menstrual disorder.

Description

A kind of Chinese medicine being used for the treatment of menoxenia

Technical field

The present invention relates to a kind of Chinese medicine, be specifically related to a kind of Chinese medicine being used for the treatment of menoxenia.

Background technology

Modern medicine thinks that menoxenia is without obvious whole body and interior external genitalia organic disease, but the gynaecopathia caused by the disorder of neuroendocrine system regulatory function, general title gynecological endocrine disease.Mainly comprise ovulatory or anovulatory dysfunctional uterine bleeding, main employing Hormone Replacement Therapy is main at present, but consolidates because its effect is deficient, and has certain side effect, is not easily accepted by patient.The traditional Chinese medical science is thought and is caused function not normal (liver spleen kidney) and disorder of QI and blood by the not outer disharmony between QI and blood of menoxenia Etiological pathogenesis, rushes the imbalance of wantonly two arteries and veins damages and kidney-menses-punching times-uterus axle and occurs menopathy.This kind of disease of Chinese medicine, has a clear superiority in and clinical efficacy.

Medical material present Research involved in the present invention is as follows:

Radix Angelicae Sinensis [another name] is dry returns, horse hair Radix Angelicae Sinensis, the Qin which, horse hair is returned, cloud is returned, western Radix Angelicae Sinensis, Min Radix Angelicae Sinensis [source] they are umbelliferae angelica root.[habitats distribution] Shaanxi, Gansu, Hubei, Sichuan, Yunnan, Guizhou.[nature and flavor] are sweet; Pungent; Bitter; Temperature.[function cures mainly] enriches blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation.The all cards of main blood deficiency; Menoxenia; Amenorrhea; Dysmenorrhea; Lump in the abdomen knot is poly-; Metrorrhagia; Asthenia cold abdominalgia; Flaccidity syndrome and arthralgia syndrome; Numbness of the skin; Dryness of the intestine dyschezia; Heavy after bloody dysentery; Ulcer sores; Injury from falling down.[extracts] " national Chinese herbal medicine compilation ".

Radix Paeoniae Rubra [another name] wooden Radix Paeoniae, Radix Paeoniae Rubra, red Radix Paeoniae, Paeonia obovata Maxim. [source] they are Paeoniaceae plant peony, CHUANSHAO medicine, Paeonia obovata Maxim., hair leaf Paeonia obovata Maxim., Paeonia mairei Lévl., Paeonia anomala and tuber Radix Paeoniae root.The 8-9 month excavates, removably upper part and earth, and dry in the sun, to time half-dried, is bundled into wisp, shines to foot dry.[nature and flavor] are bitter; Be slightly cold.[function cures mainly] clearing away heat and cooling blood; Blood circulation promoting and blood stasis dispelling.Main maculae caused by violent heat pathogen; Hematemesis and epistaxis; Discharging fresh blood stool; Conjunctival congestion and swelling pain; Carbuncle skin infection; Amenorrhea; Dysmenorrhea; Metrorrhagia and leukorrhagia stranguria with turbid discharge; The stagnant hypochondriac pain of the stasis of blood; Hernia abdominal mass is gathered; Injury from falling down.[extracts] " national pharmacopeia ".

The tuber of Radix Rehmanniae Preparata [another name] Radix Rehmanniae Preparata [source] scrophulariaceae rehmannia glutinosa plant, steams solarization through processing and forms.Get Radix Rehmanniae and add yellow wine 30%, tremble and, and in joint device, to steam to inside and outside black profit, take out and dry.Or get after Radix Rehmanniae puts and steam 8h in steaming device, at a stewing night, next day climbs over, then steams 4-8h, a more stewing night takes out, and shines to eighty per cant dry, after section, then dries.[nature and flavor] are sweet, temperature.[function cures mainly] enriches blood moist; Benefit essence fills out marrow.Main blood tiger is sallow; Dizzy cardiopalmus; Menoxenia; Collapse more than; Hepatic and renal YIN deficiency; Hectic fever night sweat; Seminal emission sexual impotence; Infertility; Soreness of the waist and knees; Hiccough and deaf; The head is dim-sighted; Early whitening of beard and hair; Quench one's thirst; Constipation; To suffer from a deficiency of the kidney dyspnea with rapid and short breath.[usage and dosage] takes orally: decoct soup, 10-30g; Or it is loose to enter ball; Or endure cream, or infusing drugs in wine.[extracts] " Bencao Tujing ".

The dry root bark of Cortex Moutan [another name] Cortex Moutan, unpeeled CORTEX MOUTAN, wooden Radix Paeoniae, bar Cortex Moutan, Luoyang flower [source] ranunculaceae peony Paeonia suffruticosa Andr..Autumn excavates root, and removing radicula, strips root bark, dry.[nature and flavor] are bitter, pungent, are slightly cold.[function cures mainly] clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.For maculae caused by violent heat pathogen, hematemesis and epistaxis, night fever abating at dawn, lossless hectic fever due to YIN-deficiency, amenorrhea dysmenorrhea, carbuncle sore tumefacting virus, falls and flutters the pain of injury.[usage and dosage] 6 ~ 12g.[extracts] " Chinese Pharmacopoeia ".

The dry root of Radix Scutellariae [another name] Radix Scutellariae, scutellaria tea, tsuchikane tea root [source] labiate Radix Scutellariae Scutellaria baicalensis Georgi.Spring, Qiu Erji excavate, and removing fibrous root and silt, hit rough bark after solarization, dry.[habitats distribution] is born in the hillside of grassland, high and dry gravel matter.The ground such as distribution Heilungkiang, Jilin, Liaoning, Hebei, Henan, Shandong, Sichuan, Yunnan, Shanxi, Shaanxi, Gansu, the Inner Mongol.[nature and flavor] are bitter, cold.[function cures mainly] heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.[extracts] " Chinese Pharmacopoeia ".

The dry mature fruit of Fructus Gardeniae [another name] Yellow Fructus Gardeniae, HUANGGUOSHU, SHANZHIZI, Fructus Gardeniae [source] Maguireothamnus speciosus Fructus Gardeniae Gardenia jasminoides Ellis, its root also can be used as medicine.Gather when 9 ~ November, fruit maturation was reddish yellow, removing carpopodium and impurity, steam supreme vapour or put in boiling water and slightly scald, take out, dry.Gen Xiaqiu excavates, and cleans and dries.[habitats distribution] is often born in the warm sparse woods in low mountain or barren hill, by ditch, roadside.The ground such as distribution Jiangsu, Zhejiang, Anhui, Jiangxi, Guangdong, Guangxi, Yunnan, Guizhou, Sichuan, Hubei, Fujian, Taiwan.Main product Zhejiang, Jiangxi, Hunan, Fujian; In addition, the ground such as Sichuan, Hubei, Yunnan, Guizhou, Jiangsu, Anhui, Guangdong, Guangxi, Henan also produces.[nature and flavor] are bitter, cold.[function cures mainly] fruit: pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.Vexed for calentura, jaundice dark coloured urine, blood strangury and dry pain, heat in blood tells nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles; External treatment bruise pain.Root: eliminating fire and detoxication, clearing away heat-damp and promoting diuresis, cool the blood dissipate blood stasis.For infectious hepatitis, traumatic injury, acute toothache.[usage and dosage] 6 ~ 9g.[extracts] " Chinese Pharmacopoeia ".

Pericarpium Citri Reticulatae Viride [another name] Sihuaqingpi, FTUCTUS CITRI IMMATURI, Pericarpium Citri Reticulatae Viride [source] rutaceae orange Citrus reticulata Blanco and the dry young fruit of variety thereof or the peel of immature fruit.5 ~ June collects the young fruit from falling, and dries, and practises and claiming " FTUCTUS CITRI IMMATURI " or " Pericarpium Citri Reticulatae Viride "; Gather for 7 ~ August green fruit, on peel, vertical profile becomes pintongs to base portion, eliminates flesh lobe, dries, and practises and claims " Sihuaqingpi ".[habitats distribution] Fujian, Zhejiang, Sichuan.In addition, the ground such as Jiangxi, Yunnan, Hunan.[nature and flavor] are bitter, pungent, temperature.[return through] returns liver, gallbladder, stomach warp.[function cures mainly] is soothing the liver dispelling the stagnated QI, removing food stagnancyization is stagnant.For distending pain in the chest and hypochondrium, hernia, nodule in the breast, acute mastitis, abdominal pain due to retention of food.[usage and dosage] 3 ~ 9g.[extracts] " Chinese Pharmacopoeia ".

The dry rhizome of Rhizoma Cyperi [another name] dried tuber, Rhizoma Cyperi, Thunder God head, Herba Caricis Phacotae, fragrant head grass, later green grass or young crops, passeris montani saturati head perfume (or spice) [source] sedge dried tuber Cyperus rotundus L..Autumn excavates, sing the hair must, put in boiling water after slightly boiling or steaming and dry, or burn and directly to dry afterwards.[habitats distribution] main product Shandong, Zhejiang, Hunan, Henan.Other areas also more production.Wherein product person in Shandong claims eastern Rhizoma Cyperi, and Zhejiang product person claim southern Rhizoma Cyperi, and quality is better.[nature and flavor] pungent, micro-hardship, micro-sweet, flat.[return through] returns liver, spleen, tri-jiao channel.[function cures mainly] promoting QI circulation for relieving depression, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea.[usage and dosage] 6 ~ 9g.[extracts] " Chinese Pharmacopoeia ".

Summary of the invention

The present invention aims to provide a kind of Chinese medicine being used for the treatment of menoxenia, by selecting suitable medical material and proportioning thereof, reaches the object of safe and effective healing menoxenia.

In order to achieve the above object, the present invention is by the following technical solutions:

A kind of Chinese medicine being used for the treatment of menoxenia, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: Radix Angelicae Sinensis 12 parts, Radix Paeoniae Rubra 12 parts, Radix Rehmanniae Preparata 10 parts, Cortex Moutan 10 parts, Radix Scutellariae 12 parts, Fructus Gardeniae 10 parts, 10 parts, Pericarpium Citri Reticulatae Viride, Rhizoma Cyperi 10 parts.

Below in conjunction with clinical laboratory data, beneficial effect of the present invention is described:

1, physical data

Inventor in November, 2013 ~ 2014 collect menoxenia patient 120 example of outpatient clinic altogether between year April, all meet menoxenia diagnostic criteria.Wherein, 17 ~ 51 years old age, average 32.6 years old; The course of disease 3 months ~ 11 years, average 5.5 years; Menstruation 7 ~ 21d in menstrual period, average 14d.All patients are divided at random treatment group 75 example and matched group 45 example.The aspects such as two groups of patient ages, the course of disease, state of an illness compare, and no significant difference, has comparability.

2, test method

2.1 Therapeutic Method

The capsule that the oral the present invention for the treatment of group obtains according to specific embodiment 3, every day 2 times.3 months courses for the treatment of.

Matched group adopts Progesterone soft gelatin capsule (Aisheng Pharmaceutical Co., Ltd., Zhejiang) oral (using according to its description), every day 2 times.3 months courses for the treatment of.

All patients treatments period monthly follows up a case by regular visits to 1 time, carries out curative effect statistics after 3 months, continues observation 2 months after effective person's drug withdrawal, observes menstruation.

3, criterion of therapeutical effect and therapeutic outcome

3.1 criterion of therapeutical effect

Criterion of therapeutical effect is drafted with reference to " Chinese medical disease clinical efficacy standard ":

Effective: after treatment, menstrual cycle returns to (28 ± 7) d, through amount, recover normal through color, menstrual period≤7d, anemia is improved, clinical symptom disappearance or substantially disappear;

Effective: menstrual cycle has larger improvement before comparatively treating, through amount, normal through color, menstrual period≤7d, anemia is improved, and clinical symptoms takes a turn for the better to some extent;

Invalid: treatment after menstrual cycle still abnormal, through amount without reduce or increase, normal or abnormal through color, menstrual period > 7d, clinical symptoms without improvement or increase the weight of.

Effectively total=effective+effectively.

3.2 therapeutic outcome

Table 1 liang group Clinical efficacy comparison

Group

n

Effective

Effectively

Invalid

Total effective rate

Recurrence

Treatment group

75

30（40%）

35

10

86.7%

2（6.67%）

Matched group

45

17（37.8%）

21

7

84.4%

17（100%）

It is higher and have no side effect that visible the present invention is used for the treatment of menoxenia obvious effective rate, not easily recurs, have the value applied.

Detailed description of the invention

In order to understand better and implement the present invention, further illustrate the present invention below in conjunction with specific embodiment.

Specific embodiment 1

Take: Radix Angelicae Sinensis 12g, Radix Paeoniae Rubra 12g, Radix Rehmanniae Preparata 10g, Cortex Moutan 10 g, Radix Scutellariae 12g, Fructus Gardeniae 10g, Pericarpium Citri Reticulatae Viride 10g, Rhizoma Cyperi 10g; Add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, is concentrated into 120 grams, must meet the decoct of adult normal's one day consumption.

Be used for the treatment of menoxenia.Oral, every bu is taken for twice sooner or later.

Specific embodiment 2

Take: Radix Angelicae Sinensis 12g, Radix Paeoniae Rubra 12g, Radix Rehmanniae Preparata 10g, Cortex Moutan 10 g, Radix Scutellariae 12g, Fructus Gardeniae 10g, Pericarpium Citri Reticulatae Viride 10g, Rhizoma Cyperi 10g; Add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1.5 hours, filters; Merging filtrate, concentrated, dry, packaging, must meet the powder of adult normal's one day consumption.

Be used for the treatment of menoxenia.Oral, daily twice.

Specific embodiment 3

Take: Radix Angelicae Sinensis 12g, Radix Paeoniae Rubra 12g, Radix Rehmanniae Preparata 10g, Cortex Moutan 10 g, Radix Scutellariae 12g, Fructus Gardeniae 10g, Pericarpium Citri Reticulatae Viride 10g, Rhizoma Cyperi 10g; Add 6 times of water gagings, decoct 3 times, each decoction 1 hour, merges decoction liquor, concentrated, dry, incapsulates shell, must meet the capsule of adult normal's one day consumption.

Be used for the treatment of menoxenia.Oral, every bu is taken for twice sooner or later.

Claims (4)

1. one kind is used for the treatment of the Chinese medicine of menoxenia, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: Radix Angelicae Sinensis 12 parts, Radix Paeoniae Rubra 12 parts, Radix Rehmanniae Preparata 10 parts, Cortex Moutan 10 parts, Radix Scutellariae 12 parts, Fructus Gardeniae 10 parts, 10 parts, Pericarpium Citri Reticulatae Viride, Rhizoma Cyperi 10 parts.

2. be used for the treatment of the Chinese medicine of menoxenia as claimed in claim 1, it is characterized in that, its preparation method is: take: Radix Angelicae Sinensis 12 parts, Radix Paeoniae Rubra 12 parts, Radix Rehmanniae Preparata 10 parts, Cortex Moutan 10 parts, Radix Scutellariae 12 parts, Fructus Gardeniae 10 parts, 10 parts, Pericarpium Citri Reticulatae Viride, Rhizoma Cyperi 10 parts; Add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, is concentrated into 120 parts, obtains decoct; Above-mentioned part all refers to weight portion.

3. be used for the treatment of the Chinese medicine of menoxenia as claimed in claim 1, it is characterized in that, its preparation method is: take: Radix Angelicae Sinensis 12 parts, Radix Paeoniae Rubra 12 parts, Radix Rehmanniae Preparata 10 parts, Cortex Moutan 10 parts, Radix Scutellariae 12 parts, Fructus Gardeniae 10 parts, 10 parts, Pericarpium Citri Reticulatae Viride, Rhizoma Cyperi 10 parts; Add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1.5 hours, filters; Merging filtrate, concentrated, dry, packaging, obtains powder; Above-mentioned part all refers to weight portion.

4. be used for the treatment of the Chinese medicine of menoxenia as claimed in claim 1, it is characterized in that, its preparation method is: take: Radix Angelicae Sinensis 12 parts, Radix Paeoniae Rubra 12 parts, Radix Rehmanniae Preparata 10 parts, Cortex Moutan 10 parts, Radix Scutellariae 12 parts, Fructus Gardeniae 10 parts, 10 parts, Pericarpium Citri Reticulatae Viride, Rhizoma Cyperi 10 parts; Add 6 times of water gagings, decoct 3 times, each decoction 1 hour, merges decoction liquor, concentrated, dry, incapsulates shell, obtains capsule; Above-mentioned part all refers to weight portion.