CN104645082B - 一种治疗肝炎的胶囊及其制备方法 - Google Patents
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Abstract
该治疗肝炎胶囊的制备方法，包括以下步骤：a、取所述重量份数的赤芝、铁线蕨、罗布麻、黑果枸杞、翠云草、金钗石斛、椿白皮，制成20目的粉末，混合均匀，按料液比1:9，加纯净水煎煮三次，每次2小时，滤过，合并滤液，浓缩成相对密度为1.22～1.33(40℃)的稠膏，然后烘干制成200目的粉末；b、取所述重量份数的槐花、天麻制成200目的粉末；然后同步骤a中的粉末混合均匀，按照0.48克一粒装入胶囊中。诸药配伍，协同效果突出，具有清热利湿、滋阴解毒、平肝安神、清肝泻火、修复肝脏受损细胞再生功能的功效，该治疗肝炎的胶囊治疗肝炎效果十分显著。
Description
技术领域
本发明属于中药领域，具体为一种治疗肝炎的胶囊及其制备方法。
背景技术
肝炎是肝脏炎症的统称。通常是指由多种致病因素--如病毒、细菌、寄生虫、化学毒物、药物、酒精、自身免疫因素等使肝脏细胞受到破坏，肝脏的功能受到损害，引起身体一系列不适症状，以及肝功能指标的异常。
中医认为肝炎患病的原因主要是正气不足。由于饮食不节、失节，损伤了脾胃而不能化湿，湿热内生，困脾伤肝，造成肝胆脾胃不和，从而加遽了对正气的损伤，导致了肝炎的发生。
中医治疗肝炎的主要治法有：1、疏肝理气法，是治疗肝炎的常用方法，尤常与其他治法配合，综合调整肝脏功能，促进气血畅通，脾胃健运，代表方剂为逍遥散、小柴胡汤。2、清热利湿法，湿热内蕴，阻滞肝胆是肝炎的常见病证特点，清热利湿消除致病因素，有助于肝功能的恢复，代表方剂有茵陈蒿汤、黄连解毒汤。3、益气健脾法，肝炎病人免疫功能低下时，健脾益气有助于提高免疫功能，并且有利于清除肝炎病毒和恢复肝功能，代表方剂有四君子汤、参苓白术散。4、活血化瘀法，肝炎日久不愈多见有瘀血表现，活血化瘀法能改善肝脏血液循环，抑制肝脏纤维组织的增生，尤其在慢性肝炎后期常用，代表方剂有大黄蜇虫丸、人参鳖甲煎。5、滋养肝肾法，慢性肝炎病久不愈，正气损伤，肝肾不足，滋养肝肾法，可提高机体的抗病能力，也有助于肝炎病毒的清除，代表方剂有一贯煎、六味地黄丸。
发明内容
本发明的目的是提供一种疗效确切、工艺简单的治疗肝炎的胶囊及其制备方法。
本发明治疗肝炎的胶囊，由以下重量份数的原料药制成：赤芝6～8份、铁线蕨24～27份、罗布麻18～20份、黑果枸杞8～10份、翠云草20～22份、金钗石斛15～17份、椿白皮10～12份、天麻2～3份、槐花3～4份。
作为优化，该治疗肝炎的胶囊，由以下重量份数的原料药制成：赤芝7份、铁线蕨25份、罗布麻19份、黑果枸杞9份、翠云草21份、金钗石斛16份、椿白皮11份、天麻3份、槐花3份。
该治疗肝炎胶囊的制备方法，包括以下步骤：
a、取所述重量份数的赤芝、铁线蕨、罗布麻、黑果枸杞、翠云草、金钗石斛、椿白皮，制成20目的粉末，混合均匀，按料液比1:9，加纯净水煎煮三次，每次2小时，滤过，合并滤液，浓缩成相对密度为1.22～1.33(40℃)的稠膏，然后烘干制成200目的粉末；
b、取所述重量份数的槐花、天麻制成200目的粉末；然后同步骤a中的粉末混合均匀，按照0.48克一粒装入胶囊中。
本发明组方中，赤芝主治虚劳、咳嗽、气喘、失眠、消化不良，恶性肿瘤等；对神经系统有抑制作用，循环系统有降压和加强心脏收缩力的作用，对呼吸系统有胸中结、益心气。铁线蕨清热解毒，利湿消肿，利尿通淋；用于痢疾，瘰疬，肺热咳嗽，肝炎，淋证，毒蛇咬伤，跌打损伤。罗布麻平肝安神，清热利水；用于肝阳眩晕，心悸失眠，浮肿尿少；高血压病，神经衰弱，肾炎浮肿。黑果枸杞用于治疗心热病、心脏病、月经不调、停经等，且药效显著；有抗衰老、改善睡眠；美容养颜、改善皮肤；补肾益精、预防癌症；护肝明目、增进视力；改善循环、增强体质；防治糖尿病的作用。翠云草清热利湿，止血，止咳；用于急性黄疸型传染性肝炎，胆囊炎，肠炎，痢疾，肾炎水肿，泌尿系感染，风湿关节痛，肺结核咯血；外用治疖肿，烧烫伤，外伤出血，跌打损伤。金钗石斛用于热病伤津、口渴舌燥、病后虚热、胃病、干呕、舌光少苔；具有增强免疫、强阴益精、生津养胃、润肺止咳、滋阴清热、生津止渴、用于热病伤津、口渴舌燥、病后虚热、抗癌、益胃生津，滋阴清热、清肝、明目、调节血脂、降血糖等。椿白皮清热燥湿，涩肠止泻，收敛止血；主治久泻久痢，月经过多，崩漏，带下，肠风便血等。天麻助阳气，补五劳七伤，通血脉，主头风，头痛，头晕虚旋，癫痫强痉，四肢挛急，语言不顺，一切中风，风痰。槐花凉血止血，清肝泻火。用于便血，痔血，血痢，崩漏，吐血，衄血，肝热目赤，头痛眩晕。诸药配伍，协同效果突出，具有清热利湿、滋阴解毒、平肝安神、清肝泻火、修复肝脏受损细胞再生功能的功效，该治疗肝炎的胶囊治疗肝炎效果十分显著。
具体实施方式
下面给出的实施例拟对本发明作进一步说明，但不能理解为是对本发明保护范围的限制，本领域技术人员根据本发明内容对本发明的一些非本质的改进和调整，仍属于本发明的保护范围。
实施例1，a、取赤芝7克、铁线蕨25克、罗布麻19克、黑果枸杞9克、翠云草21克、金钗石斛16克、椿白皮11克，制成20目的粉末，混合均匀，按料液比1:9，加纯净水煎煮三次，每次2小时，滤过，合并滤液，浓缩成相对密度为1.22～1.33(40℃)的稠膏，然后烘干制成200目的粉末；
b、取天麻3克、槐花3克制成200目的粉末；然后同步骤a中的粉末混合均匀，按照0.48克一粒装入胶囊中。
实施例2，a、取赤芝6克、铁线蕨24克、罗布麻18克、黑果枸杞8克、翠云草20克、金钗石斛15克、椿白皮10克，制成20目的粉末，混合均匀，按料液比1:9，加纯净水煎煮三次，每次2小时，滤过，合并滤液，浓缩成相对密度为1.22～1.33(40℃)的稠膏，然后烘干制成200目的粉末；
b、取天麻2克、槐花3克制成200目的粉末；然后同步骤a中的粉末混合均匀，按照0.48克一粒装入胶囊中。
实施例3，a、取赤芝8克、铁线蕨27克、罗布麻20克、黑果枸杞10克、翠云草22克、金钗石斛17克、椿白皮12克，制成20目的粉末，混合均匀，按料液比1:9，加纯净水煎煮三次，每次2小时，滤过，合并滤液，浓缩成相对密度为1.22～1.33(40℃)的稠膏，然后烘干制成200目的粉末；
b、取天麻3克、槐花4克制成200目的粉末；然后同步骤a中的粉末混合均匀，按照0.48克一粒装入胶囊中。
有关临床资料如下：
一般资料：共279例，男169例，女110例；年龄24～59 岁，平均( 43.29±13.15)岁； 病程2～18 年，平均(3.65±2.21) 年。病情分级均为重度，随机分为三组，每组93人。均排除心、脑、肾、造血系统等重要器官器质性疾病。三组一般临床资料经统计学处理无显著性差异( P＞0.05) 。
西医诊断标准:参考中华医学会肝病学分会、中华医学会感染病学分会联合制定，2005年12月2日发布的《慢性乙型肝炎防治指南》和2000年《病毒性肝炎防治方案》。有明显或持续的肝炎症状，如乏力、纳差、腹胀、尿黄、便溏等，伴有肝病面容、肝掌、蜘蛛痣、脾大(排除其他原因)，且无门静脉高压征。实验室检查血清ALT和(或)AST反复或持续升高，白蛋白降低或A/G比值异常、丙种球蛋白明显升高，并且白蛋白小于等于32g/L、胆红素大于5倍正常值上限、凝血酶原活动度60%～40%、胆碱酯酶小于2500U/L，4项检测中有1项者即可确诊。
治疗方法：三组各93例，分别服用实施例1、实施例2、实施例3治疗肝炎的胶囊，每日三次，每次三粒。30天为一疗程。
疗效标准:参考中华中医药学会内科肝病专业委员会1992年发布的《病毒性肝炎中医疗效判定标准(试行)》。治愈: 主要症状、体征消失，肝功能恢复正常，病毒复制指标阴性。好转: 主要症状、体征减轻(中医症状定量记分下降50%)或消失，肝功能好转。无效: 未达到“好转”标准。三组病例治疗后疗效比较结果见表1。
Claims (3)
1.一种治疗肝炎的胶囊；其特征在于由以下重量份数的原料药：赤芝6～8份、铁线蕨24～27份、罗布麻18～20份、黑果枸杞8～10份、翠云草20～22份、金钗石斛15～17份、椿白皮10～12份、天麻2～3份、槐花3～4份制成。
2.根据权利要求1所述治疗肝炎的胶囊，其特征在于由以下重量份数的原料药：赤芝7份、铁线蕨25份、罗布麻19份、黑果枸杞9份、翠云草21份、金钗石斛16份、椿白皮11份、天麻3份、槐花3份。
3.一种权利要求1所述治疗肝炎胶囊的制备方法，其特征在于包括以下步骤：
a、取所述重量份数的赤芝、铁线蕨、罗布麻、黑果枸杞、翠云草、金钗石斛、椿白皮，制成20目的粉末，混合均匀，按料液比1:9，加纯净水煎煮三次，每次2小时，滤过，合并滤液，浓缩成在40℃条件下相对密度为1.22～1.33的稠膏，然后烘干制成200目的粉末；
b、取所述重量份数的槐花、天麻制成200目的粉末；然后同步骤a中的粉末混合均匀。
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