CN104644705A - Preparation method of isatis root film coated tablets - Google Patents
Preparation method of isatis root film coated tablets Download PDFInfo
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- CN104644705A CN104644705A CN201510037913.5A CN201510037913A CN104644705A CN 104644705 A CN104644705 A CN 104644705A CN 201510037913 A CN201510037913 A CN 201510037913A CN 104644705 A CN104644705 A CN 104644705A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 241000334160 Isatis Species 0.000 title abstract 3
- 239000007941 film coated tablet Substances 0.000 title abstract 2
- 238000000576 coating method Methods 0.000 claims abstract description 52
- 239000011248 coating agent Substances 0.000 claims abstract description 51
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 21
- 239000000706 filtrate Substances 0.000 claims abstract description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 18
- 238000001914 filtration Methods 0.000 claims abstract description 7
- 229920002907 Guar gum Polymers 0.000 claims abstract description 6
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims abstract description 6
- 229920002472 Starch Polymers 0.000 claims abstract description 6
- 239000000665 guar gum Substances 0.000 claims abstract description 6
- 229960002154 guar gum Drugs 0.000 claims abstract description 6
- 235000010417 guar gum Nutrition 0.000 claims abstract description 6
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims abstract description 6
- 239000008108 microcrystalline cellulose Substances 0.000 claims abstract description 6
- 229940016286 microcrystalline cellulose Drugs 0.000 claims abstract description 6
- 235000019698 starch Nutrition 0.000 claims abstract description 6
- 239000008107 starch Substances 0.000 claims abstract description 6
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims abstract description 5
- 229910052708 sodium Inorganic materials 0.000 claims abstract description 5
- 239000011734 sodium Substances 0.000 claims abstract description 5
- 239000010231 banlangen Substances 0.000 claims description 13
- 235000013305 food Nutrition 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 12
- 239000007921 spray Substances 0.000 claims description 12
- 238000009210 therapy by ultrasound Methods 0.000 claims description 10
- 239000002671 adjuvant Substances 0.000 claims description 8
- 239000012528 membrane Substances 0.000 claims description 8
- 238000002137 ultrasound extraction Methods 0.000 claims description 8
- 239000000443 aerosol Substances 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 239000012141 concentrate Substances 0.000 claims description 5
- 239000008187 granular material Substances 0.000 claims description 5
- 238000004321 preservation Methods 0.000 claims description 5
- 239000003826 tablet Substances 0.000 abstract description 15
- 239000007788 liquid Substances 0.000 abstract description 8
- 238000005507 spraying Methods 0.000 abstract description 4
- 229920003064 carboxyethyl cellulose Polymers 0.000 abstract description 2
- 239000002994 raw material Substances 0.000 abstract description 2
- 244000185386 Thladiantha grosvenorii Species 0.000 abstract 1
- 235000011171 Thladiantha grosvenorii Nutrition 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 238000005096 rolling process Methods 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 30
- 238000009501 film coating Methods 0.000 description 12
- 239000007888 film coating Substances 0.000 description 11
- 239000003814 drug Substances 0.000 description 7
- 239000000463 material Substances 0.000 description 6
- 238000001035 drying Methods 0.000 description 5
- 102000011759 adducin Human genes 0.000 description 4
- 108010076723 adducin Proteins 0.000 description 4
- 235000008504 concentrate Nutrition 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 235000009508 confectionery Nutrition 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000010408 film Substances 0.000 description 3
- 235000014633 carbohydrates Nutrition 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 210000000170 cell membrane Anatomy 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 1
- 208000012895 Gastric disease Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000007935 oral tablet Substances 0.000 description 1
- 229940096978 oral tablet Drugs 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 201000009442 piebaldism Diseases 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 230000035943 smell Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000007940 sugar coated tablet Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 235000019605 sweet taste sensations Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
The invention discloses a preparation method of isatis root film coated tablets. The preparation method comprises the following steps of: (1) raw material treatment: adding 1000 parts by weight of isatis roots, extracting for two times by ultrasonic wave and 30min for each time, filtering, combining filtrates, concentrating the filtrate to 1000 parts by weight, cooling to room temperature, adding 95% ethanol to enable the ethanol content to reach 60%, refrigerating, filtering, and concentrating the filtrate to be thick paste; (2) tabletting: adding 200 parts by weight of starch and accessories, forming particles, and compressing to be tablets; and (3) coating: placing the tablets into a coating boiler, and spraying a coating liquid by the rolling coating method, wherein the dosage of the coating liquid is 0.02-0.05 parts by weight, and the coating liquid comprises the following components in percentage by weight: 10-15% of sodium carboxyethyl cellulose, 10-15% of momordica grosvenori extract, 1-3% of microcrystalline cellulose, 0.1-0.5% of guar gum and the balance of pure water.
Description
Technical field
The present invention relates to technical field of Chinese medicines, particularly relate to a kind of preparation method of Radix Isatidis thin membrane coated tablet.
Background technology
Film coating agent is a kind of a kind of material of coated oral tablet, usually be made up of film former, plasticizer, auxiliary additive and coloring agent, during use with the mixed liquor of water or water and ethanol for solvent, be sprayed on medicated core surface and can form bright and clean uniform film-coat, thus make medicated core avoid the erosion of light, oxygen, moisture, play aesthetic appeal, improve mouthfeel, hide the effects such as abnormal smells from the patient.
Film-coated technique, the production technology wrapped up by tablet with a small amount of safety non-toxic and physicochemical properties stable macromolecular material, the safety of these macromolecule coating materials is extensively approved by countries in the world already.So whole pharmaceuticals industry packaging technique development trend replaces sugar-coat with film coating, overcome its shortcoming.Film coating not only overcomes the shortcoming of sweet tablet, and has the incomparable advantage of coated tablet.Integrate following points: (1) is thin, thickness only has several micron, and label weightening finish is 2-5%, and special material-saving is cost-saving.(2) operation is simple, and coating powder can be mixed with solution-spraying peplos-drying can complete, and only needs 1-4 hour.(3) material system polymeric carbohydrate, without any side effects to body, in gastrointestinal, be digested to carbohydrate after disintegrate, can be utilized by body or be drained very soon.(4) can be made into the coating of various ways, oral cavity be molten, gastric solubleness, enteric, protection against the tide and suppository form, and can different colours be made.
Traditional packaging technique is sweet tablet, and adjuvant used is mainly Pulvis Talci, syrup etc., uses talcous coated tablet that the weight of drug core can be made to increase 50-100%, causes patient to take a large amount of and the incoherent adjuvant of pharmaceutical compositions.There is following shortcoming in traditional sweet tablet: labor intensity is large, operation is loaded down with trivial details, coating thickness, materials many (tablet weightening finish is more than 70%), and easily occurs piebaldism, variable color, sliver etc., and can not pack enteric matrix.Unsuitable to patients with gastric disease, be more not suitable for the patients such as diabetes.
Film coating is a preparation technique developed rapidly, by carrying out film coating to medicine, can improve the outward appearance of label significantly, improves the stability of label, utilizes film coating to reach regulating medicine release new technique important in recent years especially.Coordinate the development of pharmaceutical equipment, film-coated technique has realized the large production of automatization, and meets the requirement of modern GMP to pharmaceutical production equipment and production environment completely, so adopt film coating procedure to become medicine preparation factory one developing direction at large.
Summary of the invention
The object of the present invention is to provide a kind of preparation method of Radix Isatidis thin membrane coated tablet.
For achieving the above object, the technical solution used in the present invention is:
1) Feedstock treating: get Radix Isatidis 1000 weight portion and to add water ultrasonic extraction secondary, each 30min, centrifugal, filter, merging filtrate, filtrate is concentrated into 1000 weight portions, be placed to room temperature, add 95% ethanol and make alcohol content reach 60%, cold preservation, filtration, filtrate are condensed into thick paste;
2) tabletting: add starch 200 weight portion and adjuvant, make granule, is pressed into plain sheet;
3) coating: plain sheet is put in coating pan, adopt turnadle pan coating, spray into coating solution with aerosol apparatus, kettle temperature remains on 35-37 DEG C, until sprayed coating solution;
Described coating solution consumption is 0.02-0.05 weight portion, described coating solution is made up of according to weight ratio following composition: sodium hydroxyethlcellulose 10-15%, Luo Han Guo Paste In Foods 10-15%, microcrystalline Cellulose 1-3%, guar gum 0.1-0.5%, and surplus is pure water;
Described Luo Han Guo Paste In Foods obtains by the following method:
(1) ultra high pressure treatment: after being cleaned by Fructus Momordicae, broken, adds the pure water of 5-10 times of weight portion, pressure 300MPa, operative temperature 50-55 DEG C, ultra high pressure treatment 2-5min;
(2) ultrasonic Treatment: step (1) is obtained solution, ultrasonic Treatment 5-10min, operative temperature 50-55 DEG C, power is 300W;
(3) filter, concentrate: solution step (2) obtained filters, and is condensed into thick paste.
Of the present inventionly be condensed into thick paste, be preferably condensed into the thick paste that relative density is 1.15-1.20 (50 DEG C).
The preferred power 300W of described ultrasonic extraction, frequency 50KHz.
The kind of described adjuvant and consumption are conventionally.
Described coating spray into coating solution with aerosol apparatus, to adopt continuously depending on unilateral drying regime or the spray of interval spray addition adds film coating liquid.
Compared with prior art, tool of the present invention has the following advantages:
1, the present invention adds Luo Han Guo Paste In Foods in coating solution, Fructus Momordicae raw material is through ultra high pressure treatment, a period of time is kept in predetermined pressure, rapid release after making raw cell external and internal pressure reach balance, intraor extracellular osmotic pressure difference is increased suddenly, intracellular effective ingredient is through cell membrane (structure of cell membrane changes under supertension), transfer in extracellular liquid, then ultrasonic extraction is adopted again, what ultrasonic extraction utilized is strong mechanical shearing effect, promote polysaccharide, the stripping of meals Plant fiber, for the thin film coating material of drug core, there is good hydrophilic, coagulability, reversibility and dilute aqueous solution have good viscosity etc.
2, the present invention adopts Luo Han Guo Paste In Foods as coating solution components, there is good bleeding and have good cohesive with drug core, coating of the present invention only makes label weightening finish 2-5%, and sugar coated tablet (wherein major auxiliary burden composition is the external Pulvis Talci eliminated) often can make label weight increase 50%-100%.
3, add Luo Han Guo Paste In Foods in coating solution of the present invention, give coating solution sweet taste, be also applicable to diabetes patient simultaneously and use.
Detailed description of the invention
With specific embodiment, the invention will be further described below, but the present invention is not limited to these embodiments.
Embodiment 1
A kind of preparation method of Radix Isatidis thin membrane coated tablet:
1) Feedstock treating: get Radix Isatidis 1000g and to add water ultrasonic extraction secondary, each 30min, filter, merging filtrate, filtrate is concentrated into 1000g, be placed to room temperature, add 95% ethanol and make alcohol content reach 60%, it is 1.15 (50 DEG C) thick paste that cold preservation, filtration, filtrate are condensed into relative density;
2) tabletting: add starch 200g and adjuvant, make granule, is pressed into plain sheet 1000;
3) coating: plain sheet is put in coating pan, adopt turnadle pan coating, spray into coating solution with aerosol apparatus, kettle temperature remains on 35-37 DEG C, adopts the spray of continuous spraying addition to add film coating liquid, until sprayed coating solution depending on unilateral drying regime;
Described coating solution consumption is 0.02%, and described coating solution is made up of according to weight ratio following composition: sodium hydroxyethlcellulose 10%, Luo Han Guo Paste In Foods 15%, microcrystalline Cellulose 1%, guar gum 0.5%, and surplus is pure water;
Described Luo Han Guo Paste In Foods obtains by the following method:
(1) ultra high pressure treatment: after being cleaned by Fructus Momordicae, broken, adds the pure water of 5-10 times of weight portion, pressure 300MPa, operative temperature 50-55 DEG C, ultra high pressure treatment 2-5min;
(2) ultrasonic Treatment: step (1) is obtained solution, ultrasonic Treatment 5-10min, operative temperature 50-55 DEG C, power is 300W;
3) filter, concentrate: solution step (2) obtained filters, and being condensed into relative density is 1.15 (50 DEG C) thick paste.
Embodiment 2
A kind of preparation method of Radix Isatidis thin membrane coated tablet:
1) Feedstock treating: get Radix Isatidis 1000g and to add water ultrasonic extraction secondary, each 30min, filter, merging filtrate, filtrate is concentrated into 1000g, be placed to room temperature, add 95% ethanol and make alcohol content reach 60%, it is 1.20 (50 DEG C) thick paste that cold preservation, filtration, filtrate are condensed into relative density;
2) tabletting: add starch 200g and adjuvant, make granule, is pressed into plain sheet 1000;
3) coating: plain sheet is put in coating pan, adopt turnadle pan coating, spray into coating solution with aerosol apparatus, kettle temperature remains on 35-37 DEG C, adopts the spray of continuous spraying addition to add film coating liquid, until sprayed coating solution depending on unilateral drying regime;
Described coating solution consumption is 0.05%, and described coating solution is made up of according to weight ratio following composition: carboxyethyl cellulose 15%, Luo Han Guo Paste In Foods 10%, microcrystalline Cellulose 2%, guar gum 0.1%, and surplus is pure water;
Described Luo Han Guo Paste In Foods obtains by the following method:
(1) ultra high pressure treatment: after being cleaned by Fructus Momordicae, broken, adds the pure water of 5-10 times of weight portion, pressure 300MPa, operative temperature 50-55 DEG C, ultra high pressure treatment 2-5min;
(2) ultrasonic Treatment: step (1) is obtained solution, ultrasonic Treatment 5-10min, operative temperature 50-55 DEG C, power is 300W;
(3) filter, concentrate: solution step (2) obtained filters, and being condensed into relative density is 1.20 (50 DEG C) thick paste.
Embodiment 3
A kind of preparation method of Radix Isatidis thin membrane coated tablet:
1) Feedstock treating: get Radix Isatidis 1000g and to add water ultrasonic extraction secondary, each 30min, filter, merging filtrate, filtrate is concentrated into 1000g, be placed to room temperature, add 95% ethanol and make alcohol content reach 60%, it is 1.18 (50 DEG C) thick paste that cold preservation, filtration, filtrate are condensed into relative density;
2) tabletting: add starch 200g and adjuvant, make granule, is pressed into plain sheet 1000;
3) coating: plain sheet is put in coating pan, adopt turnadle pan coating, spray into coating solution with aerosol apparatus, kettle temperature remains on 35-37 DEG C, adopts the spray of interval spray addition to add film coating liquid, until sprayed coating solution depending on unilateral drying regime;
Described coating solution consumption is 0.03%, and described coating solution is made up of according to weight ratio following composition: sodium hydroxyethlcellulose 12%, Luo Han Guo Paste In Foods 12%, microcrystalline Cellulose 3%, guar gum 0.3%, and surplus is pure water;
Described Luo Han Guo Paste In Foods obtains by the following method:
(1) ultra high pressure treatment: after being cleaned by Fructus Momordicae, broken, adds the pure water of 5-10 times of weight portion, pressure 300MPa, operative temperature 50-55 DEG C, ultra high pressure treatment 2-5min;
(2) ultrasonic Treatment: step (1) is obtained solution, ultrasonic Treatment 5-10min, operative temperature 50-55 DEG C, power is 300W;
(3) filter, concentrate: solution step (2) obtained filters, and being condensed into relative density is 1.18 (50 DEG C) thick paste.
Claims (2)
1. a preparation method for Radix Isatidis thin membrane coated tablet, is characterized in that, the technical scheme of employing is:
1) Feedstock treating: get Radix Isatidis 1000 weight portion and to add water ultrasonic extraction secondary, each 30min, filters, merging filtrate, filtrate is concentrated into 1000 weight portions, is placed to room temperature, adding 95% ethanol makes alcohol content reach 60%, and cold preservation, filtration, filtrate are condensed into thick paste;
2) tabletting: add starch 200 weight portion and adjuvant, make granule, is pressed into plain sheet;
3) coating: plain sheet is put in coating pan, adopt turnadle pan coating, spray into coating solution with aerosol apparatus, kettle temperature remains on 35-37 DEG C, until sprayed coating solution;
Described coating solution consumption is 0.02-0.05 weight portion, described coating solution is made up of according to weight ratio following composition: sodium hydroxyethlcellulose 10-15%, Luo Han Guo Paste In Foods 10-15%, microcrystalline Cellulose 1-3%, guar gum 0.1-0.5%, and surplus is pure water;
Described Luo Han Guo Paste In Foods obtains by the following method:
(1) ultra high pressure treatment: after being cleaned by Fructus Momordicae, broken, adds the pure water of 5-10 times of weight portion, pressure 300MPa, operative temperature 50-55 DEG C, ultra high pressure treatment 2-5min;
(2) ultrasonic Treatment: step (1) is obtained solution, ultrasonic Treatment 5-10min, operative temperature 50-55 DEG C, power is 300W;
(3) filter, concentrate: solution step (2) obtained filters, and is condensed into thick paste.
2. the preparation method of Radix Isatidis thin membrane coated tablet according to claim 1, is characterized in that: described in be condensed into thick paste, be condensed into the thick paste that relative density is 1.15-1.20.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510037913.5A CN104644705B (en) | 2015-01-26 | 2015-01-26 | A kind of preparation method of Radix Isatidis thin membrane coated tablet |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510037913.5A CN104644705B (en) | 2015-01-26 | 2015-01-26 | A kind of preparation method of Radix Isatidis thin membrane coated tablet |
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| Publication Number | Publication Date |
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| CN104644705A true CN104644705A (en) | 2015-05-27 |
| CN104644705B CN104644705B (en) | 2018-01-23 |
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| CN201510037913.5A Active CN104644705B (en) | 2015-01-26 | 2015-01-26 | A kind of preparation method of Radix Isatidis thin membrane coated tablet |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110669095A (en) * | 2019-10-14 | 2020-01-10 | 广西壮族自治区科学技术情报研究所 | Extraction method of high-purity mogroside V |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1723981A (en) * | 2005-07-06 | 2006-01-25 | 广西中医学院制药厂 | Novel use of extractive of Momordica grosvenori as adjuvant drug for preparing medicine |
| CN103316056A (en) * | 2013-06-24 | 2013-09-25 | 江苏鹏鹞药业有限公司 | Radix isatidis coating dispersible tablet and preparation method thereof |
-
2015
- 2015-01-26 CN CN201510037913.5A patent/CN104644705B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1723981A (en) * | 2005-07-06 | 2006-01-25 | 广西中医学院制药厂 | Novel use of extractive of Momordica grosvenori as adjuvant drug for preparing medicine |
| CN103316056A (en) * | 2013-06-24 | 2013-09-25 | 江苏鹏鹞药业有限公司 | Radix isatidis coating dispersible tablet and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 倪健: "《200种中药片剂制备关键技术》", 31 January 2008, 化学工业出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110669095A (en) * | 2019-10-14 | 2020-01-10 | 广西壮族自治区科学技术情报研究所 | Extraction method of high-purity mogroside V |
| CN110669095B (en) * | 2019-10-14 | 2022-05-27 | 广西壮族自治区科学技术情报研究所 | Extraction method of high-purity mogroside V |
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Denomination of invention: Preparation method of Banlangen film coated tablets Effective date of registration: 20221010 Granted publication date: 20180123 Pledgee: Agricultural Bank of China Limited Pubei County Sub branch Pledgor: GUANGXI SHIBIAO PHARMACEUTICAL Co.,Ltd. Registration number: Y2022450000171 |
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Date of cancellation: 20230928 Granted publication date: 20180123 Pledgee: Agricultural Bank of China Limited Pubei County Sub branch Pledgor: GUANGXI SHIBIAO PHARMACEUTICAL Co.,Ltd. Registration number: Y2022450000171 |
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Denomination of invention: A Preparation Method for Banlangen Film Coated Tablets Effective date of registration: 20231010 Granted publication date: 20180123 Pledgee: Agricultural Bank of China Limited Pubei County Sub branch Pledgor: GUANGXI SHIBIAO PHARMACEUTICAL Co.,Ltd. Registration number: Y2023980060614 |