CN104629096B - A kind of obstruct PM2.5 and the former gel of other nasal allergies - Google Patents
A kind of obstruct PM2.5 and the former gel of other nasal allergies Download PDFInfo
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- CN104629096B CN104629096B CN201410353898.0A CN201410353898A CN104629096B CN 104629096 B CN104629096 B CN 104629096B CN 201410353898 A CN201410353898 A CN 201410353898A CN 104629096 B CN104629096 B CN 104629096B
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Abstract
The invention provides a kind of gel for intercepting PM2.5 or other nasal allergies original in air, in addition to purified water, it includes component of following weight proportion：Polyquaternium 0.2%~20%, cation guar gum：0.1%~10%.Present invention also offers the preparation method and purposes of the gel.The effective PM2.5 particulate matters and other nasal allergy originals intercepted in air enters human respiratory to the present invention for convenience, a kind of gel products configured as primary raw material with cationic substance polyquaternium and guar gum are provided first, it is applied to user's nose, by various cations electrostatic field as an air filter screen is produced around nasal meatus, the particulate matter (particularly PM2.5) that can effectively block in air enters the respiratory systems such as nasal meatus, lung, while PM2.5 is intercepted, other nasal allergy sources in air can be also intercepted：Grass cuttings, pollen, dust mite, animals and plants scurf etc. enter respiratory system, it is to avoid cause nose allergy, protection respiratory system, cardio-pulmonary function etc. healthy.
Description
Technical field
The present invention relates to a kind of gel for intercepting PM2.5 or other nasal allergies original in air.
Background technology
China in Recent Years major part urban air pollution is serious, and haze takes place frequently, and bulky grain thing is easily by nasal cavity, pharynx in air
Larynx, tracheae is intercepted, or is excluded in vitro by the motion of fine hair, and PM2.5 is tiny particles content, once by people from breathing
Road is sucked, and will be deposited on the alveolar of people, then dissolves blood of entering, and causes septicemia, it is easy to reach deep lung, meeting
The injury of respiratory system and cardiovascular system is caused, respiratory tract occurs, coughed, expiratory dyspnea aggravates asthma attack, occurs
Arrhythmia induction heart disease etc., therefore PM2.5 indexes have become an index for important observing and controlling air pollution degree.
The current most domestic common people are the pollution of reply PM2.5, it is common to use mouth mask is tackled, but general mouth mask
Cannot prevent pellet, medical mask mainly for more than PM3 pellet, for below PM2.5 can
The effect for sucking particulate matter is smaller；Preferably, filtering PM2.5 fine particle efficiency is greater than 95% to PM2.5 mouth masks effect, but it has
Shortcoming is also particularly evident：Respiratory impedance is higher, is not suitable for child, pregnant woman, heart or the respiratory system person of having any problem and skin sensitivity
Person uses；It is at atmosphere draught-free or indoor it is not recommended that using；Can not for a long time wear masks, schneiderian membrance is become fragile,
Lose original physiological function of nasal cavity；Mouth mask outer layer is easily infected with dirt and bacterium, and the easy endophytic bacteria of internal layer need to be cleaned, one daily
The need of secondary property are changed daily, relatively costly.
The content of the invention
PM2.5 in air can be conveniently and effectively intercepted it is an object of the invention to provide a kind of or other nasal allergies are former
Gel.Preparation method and purposes another object of the present invention is to provide the gel.
The invention provides a kind of gel for intercepting PM2.5 or other nasal allergies original in air, in addition to purified water, it includes
The component of following weight proportion：
Polyquaternium 0.2%~20%, cation guar gum：0.1%~10%.
The effective PM2.5 particulate matters and other nasal allergy originals intercepted in air enters human body respiration to the present invention for convenience
System, provides a kind of gel product configured as primary raw material with cationic substance polyquaternium and cation guar gum first
Product, are applied to user's nose, and electrostatic as an air filter screen is produced around nasal meatus by various cations
, the particulate matter (particularly PM2.5) that can effectively block in air enters the respiratory systems such as nasal meatus, lung, is intercepting the same of PM2.5
When, can also intercept other nasal allergy sources in air：Grass cuttings, pollen, dust mite, animals and plants scurf etc. enter respiratory system, it is to avoid draw
Play nose allergy, protection respiratory system, cardio-pulmonary function etc. healthy.
Present invention research finds that the addition of cation guar gum can cause that the proterties of gel is not more fine and smooth sticky, energy
Enough make gel uniform application in nose, increase the barriering effect and comfortableness of product, if using polyquaternary amine salt merely,
Can then cause that product adhesion is strong, wire drawing phenomenon is serious, and not easy to clean, using inconvenience, barriering effect can decline.Therefore,
Cation guar gum and polyquaternary amine salt are indispensable critical materialses in inventive gel product.
Further, the polyquaternium be selected from polyquaternium -6, polyquaternium -7, Polyquaternium-10, polyquaternium -
22, polyquaternium -39, polyquaternium -47, one or more the composition in polyquaternium -76.
Further, the polyquaternium be selected from Polyquaternium-10 and polyquaternium -6 in one or more
Combination.
In the specific embodiment of the invention, the polyquaternium for using is selected from the combination of Polyquaternium-10 and polyquaternium -6,
Both weight proportions are respectively：
Polyquaternium-10：0.1%~10%, polyquaternium -6：0.1%~10%.
Further, it also includes the component of following weight proportion：
NMF 0~8%, preservative 0~1%, bacteriostatic agent 0~10%, chelating agent 0~1%；It is 0 when each component is different；
Preferably, it also includes the component of following weight proportion：NMF 2~8%, preservative 0.1~1%, bacteriostatic agent
0.1~10%, chelating agent 0.05%~1%.
Preservative is the anti-corrosion for product itself in the present invention, and bacteriostatic agent is mainly used in product and uses bacterium in rear air
Suppression.
Further, the NMF be selected from glycerine, propane diols, xylitol, butanediol, polyethylene glycol in one kind or
Two or more combinations；Preservative be selected from Sodium Methyl Hydroxybenzoate, potassium sorbate, Sodium Benzoate in one or two with
On combination；Bacteriostatic agent be selected from shitosan, caryophyllus oil, lavender oil, rosemary oil, sage oil, thyme linaloe oil, tangerine oil,
One or more combination in grape-fruit seed oil；Chelating agent is selected from ethylenediamine tetra-acetic acid or its salt；Further, the second two
Amine tetraacetate is selected from tetrasodium ethylenediamine tetraacetate or disodium ethylene diamine tetraacetate.
Further, it is made up of the component of following weight proportion：
Polyquaternium-10：0.1%~10%, polyquaternium -6：0.1%~10%, cation guar gum：0.1%~
10%, shitosan：0.1%~10%, glycerine：1%~5%, propane diols：1%~3%, tetrasodium ethylenediamine tetraacetate：0.05%
~1%, Sodium Methyl Hydroxybenzoate：0%~1%, purified water：Surplus.
The said goods have certain bacteriostatic activity, and antimicrobial environment is formed position is smeared, and suppress particulate in air institute
Growth with harmful bacteria.
Present invention also offers the preparation method of above-mentioned gel, concrete operation step is as follows：
(1) Polyquaternium-10, polyquaternium -6 are dissolved in purified water, obtain solution A, it is standby；
(2) cation guar gum, shitosan are dissolved in purified water, obtain solution B, it is standby；
(3) tetrasodium ethylenediamine tetraacetate, Sodium Methyl Hydroxybenzoate are dissolved in purified water, obtain solution C, it is standby
With；
(4) solution A, B and C are mixed, in glycerine and propane diols addition mixed solution, is mixed, obtain final product gel.
Present invention also offers purposes of the above-mentioned gel in the external preparation for intercepting particulate in air is prepared.
Further, the particulate in air is PM2.5.
Present invention also offers purposes of the above-mentioned gel in the external preparation for intercepting nasal allergy source is prepared.
Further, the nasal allergy source is grass cuttings, pollen, dust mite or animals and plants scurf.
The invention provides a kind of gel configured as primary raw material with cationic substance polyquaternium and guar gum
Product, the gel is applied to nose, and the PM2.5 particles that can effectively block in air enter the respiratory systems such as nasal meatus, lung, keep away
Exempt to cause nose allergy, protect respiratory system, and antimicrobial environment is formed position is smeared, suppress particulate in air and carried
The growth of evil bacterium.Said preparation is non-toxic to human body, nonirritant without sensitivity response, with good biocompatibility and can
Degradability.
Specific embodiment
Embodiment 1
| Composition | Ratio in prescription | Recipe quantity |
| Purified water | 85.4% | 85.4 |
| Polyquaternium-10 | 0.5% | 0.5 |
| Polyquaternium -6 | 0.5% | 0.5 |
| Cation guar gum | 8% | 2 |
| Shitosan | 0.5% | 0.5 |
| Glycerine | 3% | 3 |
| Propane diols | 1% | 1 |
| Tetrasodium ethylenediamine tetraacetate | 0.1% | 0.1 |
| Sodium Methyl Hydroxybenzoate | 1% | 1 |
Preparation method：
(1) by Polyquaternium-10, polyquaternium -6 is dissolved in purified water, obtains solution A, standby；
(2) by cation guar gum, shitosan is dissolved in purified water, obtains solution B, standby；
(3) by tetrasodium ethylenediamine tetraacetate, Sodium Methyl Hydroxybenzoate is dissolved in purified water, obtains solution C, standby
With；
(4) solution A, B and C are mixed, in glycerine and propane diols addition mixed solution, stirring；
(5) gel products will be obtained after 4 resulting solution de-bubbles, sterile filling.
Embodiment 2
| Composition | Ratio in prescription | Recipe quantity |
| Purified water | 87.4% | 87.4 |
| Polyquaternium-10 | 4% | 4 |
| Polyquaternium -6 | 0.5% | 0.5 |
| Cation guar gum | 2.5% | 2.5 |
| Shitosan | 0.5% | 0.5 |
| Glycerine | 3% | 3 |
| Propane diols | 1% | 1 |
| Tetrasodium ethylenediamine tetraacetate | 0.1% | 0.1 |
| Sodium Methyl Hydroxybenzoate | 1% | 1 |
Preparation method：
(1) by Polyquaternium-10, polyquaternium -6 is dissolved in purified water, obtains solution A, standby；
(2) by cation guar gum, shitosan is dissolved in purified water, obtains solution B, standby；
(3) by tetrasodium ethylenediamine tetraacetate, Sodium Methyl Hydroxybenzoate is dissolved in purified water, obtains solution C, standby
With；
(4) solution A, B and C are mixed, in glycerine and propane diols addition mixed solution, stirring；
(5) gel products will be obtained after 4 resulting solution de-bubbles, sterile filling.
Beneficial effects of the present invention are illustrated below by way of test example.
Iris action of the inventive gel of test example 1 to particulate in air
1st, purpose
Observation inventive gel (in the present invention alternatively referred to as " PM2.5 resistance noses are quick ") is to air pollutants (air fine grained
Thing PM10, superfine particulate matter) barriering effect.
2nd, sample
Instrument：YT-HPC3000A (rising electronics forever in Chengdu) sets 4 sampled points in same place, smart respectively with assay balance
Really weigh 25mg, the PM2.5 resistance noses of 50mg, 75mg are quick, and (gel used takes from implementation in the experiment used as basic, normal, high dosage group
Example 2), uniform application to 3 surfaces of the sampling head equipped with PM2.5, PM10 impact head, it is ensured that smear uniform without foaming, do not go out
Situations such as existing gas leakage, an instrument is separately taken, keep detecting head surface cleaning, it is quick not smear PM2.5 resistance noses, as a control group；4 surveys
Examination instrument is placed on the height apart from 1.5 meters of ground, keeps probe of tester to be in same position.
Sampling time：60s.
Sampled result is shown in Table 1.
Table 1
It can be seen from the data of table 1, gel prepared by the present invention can effectively intercept the particulate matter in air, and to different-grain diameter
Particulate matter have iris action.
The iris action to particulate in air of the different auxiliary material gel of test example 2
With the polyquaternium of test example 1 and guar gum isoreactivity raw material it is constant, change other auxiliary materials in the case of, by experiment
The experiment of example 1 is operated, and the results are shown in Table 2~5：
The not adding preservative agent gel of table 2
Table 3 is not added with chelating agent gel
Table 4 is not added with bacteriostatic agent gel
Table 5 is not added with NMF gel
Conclusion：
From the result of table 1- tables 4, in the case of polyquaternium and guar gum ratio identical, not adding preservative agent, chelating
Agent, bacteriostatic agent or NMF, product are basic to the barriering effect of air pollutants (airborne fine particulate matter PM10, superfine particulate matter)
Remain unchanged, illustrate that polyquaternium of the present invention and guar gum are the key components for intercepting air particle.
Influence of the cation guar gum of test example 3 to gel
With the polyquaternium of test example 1 and other auxiliary materials it is constant, be not added with cation guar gum in the case of, by test example 1
Experiment is operated, and proterties and test result are shown in Table 6 and table 7：
Table 6 is not added with the change of cation guar gum gel character
Table 7 is not added with cation guar gum gel
Conclusion：
From table 6 and the result of table 7, in the case of polyquaternium and other auxiliary material proportion identicals, cation melon is not added with
That glue, the proterties of product is poor, and the barriering effect to air pollutants (airborne fine particulate matter PM10, superfine particulate matter) has substantially
The trend for diminishing, illustrates that guar gum of the present invention is the key component for intercepting air particle.
Claims (13)
- It is 1. a kind of to intercept PM2.5 or the former gel of other nasal allergies in air, it is characterised in that：In addition to purified water, it is included such as The component of lower weight proportion：Polyquaternium 0.2% ~ 20%, cation guar gum：0.1%~10%；The polyquaternium be selected from polyquaternium -6, polyquaternium -7, Polyquaternium-10, Merquat 280, polyquaternium - 39, polyquaternium -47, one or more the composition in polyquaternium -76.
- 2. gel according to claim 1, it is characterised in that：The polyquaternium is selected from Polyquaternium-10 and polyquaternary amine One or more combination in salt -6.
- 3. gel according to claim 2, it is characterised in that：The polyquaternium is selected from Polyquaternium-10 and polyquaternary amine The combination of salt -6, both weight proportions are respectively：Polyquaternium-10：0.1%~10%, polyquaternium -6：0.1%~10%.
- 4. the gel according to claims 1 to 3 any one, it is characterised in that：It also includes the group of following weight proportion Point：NMF 0~8%, preservative 0~1%, bacteriostatic agent 0~10%, chelating agent 0~1%；It is 0 when each component is different.
- 5. gel according to claim 4, it is characterised in that：It also includes the component of following weight proportion：NMF 2~ 8%, preservative 0.1~1%, bacteriostatic agent 0.1~10%, chelating agent 0.05~1%.
- 6. gel according to claim 4, it is characterised in that：The NMF is selected from glycerine, propane diols, xylitol, fourth One or more combination in glycol, polyethylene glycol；Preservative be selected from Sodium Methyl Hydroxybenzoate, potassium sorbate, One or more combination in Sodium Benzoate；Bacteriostatic agent is selected from shitosan, caryophyllus oil, lavender oil, rosemary oil, mouse One or more combination in tail grass oil, thyme linaloe oil, tangerine oil, grape-fruit seed oil；Chelating agent is selected from ethylenediamine tetra-acetic acid Or its salt.
- 7. gel according to claim 6, it is characterised in that：The edetate is selected from ethylenediamine tetra-acetic acid four Sodium or disodium ethylene diamine tetraacetate.
- 8. gel according to claim 1, it is characterised in that：It is made up of the component of following weight proportion：Polyquaternium-10：0.1%~10%, polyquaternium -6：0.1%~10%, cation guar gum：0.1%~10%, shitosan： 0.1%~10%, glycerine：1%~5%, propane diols：1%~3%, tetrasodium ethylenediamine tetraacetate：0.05%~1%, P-hydroxybenzoic acid first Ester sodium：0.1%~1%, purified water：Surplus.
- 9. the preparation method of gel described in claim 8, it is characterised in that：Concrete operation step is as follows：（1）Polyquaternium-10, polyquaternium -6 are dissolved in purified water, solution A is obtained, it is standby；（2）Cation guar gum, shitosan are dissolved in purified water, solution B is obtained, it is standby；（3）Tetrasodium ethylenediamine tetraacetate, Sodium Methyl Hydroxybenzoate are dissolved in purified water, solution C is obtained, it is standby；（4）Solution A, B and C are mixed, in glycerine and propane diols addition mixed solution, is mixed, obtain final product gel.
- 10. gel described in claim 1 ~ 8 any one prepare intercept particulate in air external preparation in purposes.
- 11. purposes according to claim 10, it is characterised in that：The particulate in air is PM2.5.
- Gel described in 12. claim 1 ~ 8 any one is preparing the purposes in intercepting the former external preparation of nasal allergy.
- 13. purposes as claimed in claim 12, it is characterised in that：The nasal allergy was grass cuttings, pollen, dust mite or animals and plants originally Scurf.
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| CN201410353898.0A CN104629096B (en) | 2014-07-23 | 2014-07-23 | A kind of obstruct PM2.5 and the former gel of other nasal allergies |
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| US9737497B2 (en) * | 1993-06-24 | 2017-08-22 | Trutek Corp. | Electrostatically charged nasal application method and product for micro-filtration |
| CN108277647A (en) * | 2017-01-06 | 2018-07-13 | 成都瑞沐生物医药科技有限公司 | Particulate matter barrier material and its application in haze |
| CN111265473A (en) * | 2018-12-04 | 2020-06-12 | 南京从一医药科技有限公司 | Dual-functional nose protection gel with foreign matter blocking and sterilization effects |
| CN109984994A (en) * | 2019-03-25 | 2019-07-09 | 南京天朗制药有限公司 | A kind of pollen blocking agent and its preparation method and application |
| CN111568804A (en) * | 2020-06-23 | 2020-08-25 | 广州澳希亚实业有限公司 | Pollen-blocking composition and protective product containing same |
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| US7618617B2 (en) * | 2002-05-31 | 2009-11-17 | L'oreal | Aqueous hair treatment compositions, thickened with an amphiphilic linear block copolymer |
| CN102119879B (en) * | 2011-01-28 | 2013-06-19 | 武汉耦合医学科技有限责任公司 | Antiallergic gel nose-protecting medical supply and making method thereof |
| CN103356400A (en) * | 2013-07-16 | 2013-10-23 | 浙江九九红玫瑰科技有限公司 | Soap-base facial cleanser and preparation method thereof |
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Effective date of registration: 20180816 Address after: 610000 Tianfu international bio City, Chengdu, Sichuan, 18 (two section of Bijie Road, Shuangliu District) Patentee after: Chengdu Noho Sheng Tai Biotechnology Co., Ltd. Address before: 610093 No. 12, No. 88, Keyuan South Road, hi tech Zone, Chengdu, Sichuan. Patentee before: CHENGDU HAILU BIOLOGICAL TECHNOLOGY CO., LTD. |