CN104622811A - Formula of veterinary chlortetracycline hydrochloride soluble powder and preparation method thereof - Google Patents
Formula of veterinary chlortetracycline hydrochloride soluble powder and preparation method thereof Download PDFInfo
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- CN104622811A CN104622811A CN201510044933.5A CN201510044933A CN104622811A CN 104622811 A CN104622811 A CN 104622811A CN 201510044933 A CN201510044933 A CN 201510044933A CN 104622811 A CN104622811 A CN 104622811A
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- chlortetracycline hydrochloride
- soluble powder
- animals
- sodium lauryl
- chlortetracycline
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Abstract
The invention discloses a formula of veterinary chlortetracycline hydrochloride soluble powder and a preparation method thereof. The soluble powder is prepared from the following components in percentage by weight: 10-50 percent of chlortetracycline hydrochloride, 0.2-3.0 percent of sodium dodecyl sulfate, 0.1-1.0 percent of ethylenediamine tetraacetic acid disodium salt and the balance of glucosum anhydricum. The chlortetracycline hydrochloride is utilized as a raw material, sodium dodecyl sulfate is added as an absorption enhancer, and ethylenediamine tetraacetic acid disodium salt is utilized as an antioxidant and a chelating agent, so that the stability and high efficiency of chlortetracycline hydrochloride soluble powder are ensured.
Description
Technical field
The present invention relates to a kind of chlortetracycline hydrochloride soluble powder formula for animals and preparation method thereof, belong to veterinary drug preparing technical field.
Background technology
Existing market chlortetracycline hydrochloride soluble powder, because chlortetracycline is unstable, is easy to oxidation, variable color, has a significant impact the stability of preparation and therapeutic effect.
Summary of the invention
For above-mentioned problems of the prior art, the invention provides chlortetracycline hydrochloride soluble powder formula for animals and preparation method thereof
,promote drug absorption, reduce Ca
2+, Mg
2+deng the interference effect that metal ion absorbs chlortetracycline, improve absorbance and the bioavailability of chlortetracycline principal agent.
To achieve these goals, a kind of chlortetracycline hydrochloride soluble powder for animals of stability and high efficiency in solution of the present invention, it is characterized in that, be made up of following raw material by weight percentage: chlortetracycline hydrochloride 10 ~ 55%, sodium lauryl sulphate salt 0.2 ~ 3%, disodium EDTA 0.1 ~ 1%, the anhydrous glucose of surplus.
A kind of preparation technology of chlortetracycline hydrochloride soluble powder for animals of stability and high efficiency, it is characterized in that, after comprising the steps: chlortetracycline hydrochloride, sodium lauryl sulphate salt, disodium EDTA, anhydrous glucose to pulverize and sieve respectively, take chlortetracycline hydrochloride 15 ~ 55% by weight percentage, sodium lauryl sulphate salt 0.2 ~ 3%, disodium EDTA 0.1 ~ 1%, the anhydrous glucose of surplus, 1 hour is fully mixed with equal increments method, after mix homogeneously, obtain the chlortetracycline hydrochloride soluble powder for animals of stability and high efficiency of the present invention.
Wherein goodly to consist of: chlortetracycline hydrochloride 20 ~ 50% by weight percentage, sodium lauryl sulphate salt 0.3 ~ 2.5%, disodium EDTA 0.2 ~ 0.8%, surplus is anhydrous glucose.
The best consists of: chlortetracycline hydrochloride 20% by weight percentage, sodium lauryl sulphate salt 2.0%, disodium EDTA 0.6%, and surplus is anhydrous glucose.
Chlortetracycline hydrochloride soluble powder for animals of the present invention, in order to ensure the stable of preparation and absorb high efficiency, add sodium lauryl sulphate salt as absorption enhancer, to improve medicine absorption strength in vivo, add disodium EDTA as antioxidant and chelating agen simultaneously, prevent chlortetracycline hydrochloride oxidation stain, and improve medicine stability in vivo.
Detailed description of the invention
Chlortetracycline hydrochloride, sodium lauryl sulphate salt, disodium EDTA, anhydrous glucose are pulverized respectively, crosses No. 5 sieves for subsequent use.
Embodiment 1
Take the chlortetracycline hydrochloride 10kg after sieving, sodium lauryl sulphate salt 0.25kg, disodium EDTA 0.15kg, anhydrous glucose 84.6kg, after fully mixing 1 hour with equal increments method, obtain the chlortetracycline hydrochloride soluble powder for animals of efficient stable of the present invention.
Embodiment 2
Take the chlortetracycline hydrochloride 15kg after sieving, sodium lauryl sulphate salt 0.3kg, disodium EDTA 0.2kg, anhydrous glucose 84.5kg, after fully mixing 1 hour with equal increments method, obtain the chlortetracycline hydrochloride soluble powder for animals of efficient stable of the present invention.
Embodiment 3
Take the chlortetracycline hydrochloride 20kg after sieving, sodium lauryl sulphate salt 0.5kg, disodium EDTA 0.3kg, anhydrous glucose 79.2kg, fully mixing is after 1 hour, obtains the chlortetracycline hydrochloride soluble powder for animals of efficient stable of the present invention.
Embodiment 4
Take the chlortetracycline hydrochloride 30kg after sieving, sodium lauryl sulphate salt 1.0kg, disodium EDTA 0.5kg, anhydrous glucose 68.5kg, after fully mixing 1 hour with equal increments method, obtain the chlortetracycline hydrochloride soluble powder for animals of efficient stable of the present invention.
Embodiment 5
Take the chlortetracycline hydrochloride 40kg after sieving, sodium lauryl sulphate salt 1.6kg, disodium EDTA 0.5kg, anhydrous glucose 57.6kg, after fully mixing 1 hour with equal increments method, obtain the chlortetracycline hydrochloride soluble powder for animals of efficient stable of the present invention.
Embodiment 6
Take the chlortetracycline hydrochloride 50kg after sieving, sodium lauryl sulphate salt 2.2kg, disodium EDTA 0.6kg, anhydrous glucose 47.2kg, after fully mixing 1 hour with equal increments method, obtain the chlortetracycline hydrochloride soluble powder for animals of efficient stable of the present invention.
Claims (4)
1. the chlortetracycline hydrochloride soluble powder for animals of a stability and high efficiency, it is characterized in that being made up of following raw material by weight percentage: chlortetracycline hydrochloride 10 ~ 50%, sodium lauryl sulphate salt 0.2 ~ 3.0%, disodiumedetate 0.1 ~ 1.0%, surplus is anhydrous glucose.
2. the chlortetracycline hydrochloride soluble powder for animals of stability and high efficiency according to claim 1, it is characterized in that, be made up of following raw material by weight percentage: chlortetracycline hydrochloride 10 ~ 30%, sodium lauryl sulphate salt 0.2 ~ 2.0%, disodiumedetate 0.1 ~ 0.5%, surplus is anhydrous glucose.
3. the chlortetracycline hydrochloride soluble powder for animals of stability and high efficiency according to claim 1, it is characterized in that, be made up of following raw material by weight percentage: chlortetracycline hydrochloride 35 ~ 50%, sodium lauryl sulphate salt 1.0 ~ 3.0%, disodiumedetate 0.4 ~ 1.0%, surplus is anhydrous glucose.
4. the preparation technology of the chlortetracycline hydrochloride soluble powder for animals of stability and high efficiency according to claim 1, it is characterized in that, comprise the steps: chlortetracycline hydrochloride, sodium lauryl sulphate salt, disodiumedetate, after anhydrous glucose pulverizes and sieves respectively, get chlortetracycline hydrochloride 15 ~ 50% by weight percentage, sodium lauryl sulphate salt 0.2 ~ 3.0%, disodium EDTA 0.1 ~ 1.0%, the anhydrous glucose of surplus, 1 hour is fully mixed with equal increments method, after mix homogeneously, namely the chlortetracycline hydrochloride soluble powder for animals of stability and high efficiency of the present invention is obtained.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510044933.5A CN104622811A (en) | 2015-01-29 | 2015-01-29 | Formula of veterinary chlortetracycline hydrochloride soluble powder and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510044933.5A CN104622811A (en) | 2015-01-29 | 2015-01-29 | Formula of veterinary chlortetracycline hydrochloride soluble powder and preparation method thereof |
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| CN104622811A true CN104622811A (en) | 2015-05-20 |
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| CN201510044933.5A Pending CN104622811A (en) | 2015-01-29 | 2015-01-29 | Formula of veterinary chlortetracycline hydrochloride soluble powder and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104721143A (en) * | 2015-02-13 | 2015-06-24 | 正大联合动物制药科技（江苏）有限公司 | Stable and efficient chlortetracycline hydrochloride soluble powder for livestock and preparation technology thereof |
| CN105997924A (en) * | 2016-07-07 | 2016-10-12 | 驻马店华中正大有限公司 | Chlortetracycline hydrochloride effervescent tablets and preparation method thereof |
| CN106420620A (en) * | 2016-09-28 | 2017-02-22 | 重庆大学 | Aureomycin mesilate soluble powder and preparation method thereof |
| CN107951843A (en) * | 2017-12-29 | 2018-04-24 | 浦城正大生化有限公司 | A kind of aureomycin hydrochloride soluble powder and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3639560A (en) * | 1969-07-08 | 1972-02-01 | Beecham Group Ltd | Veterinary treatment |
| CN103417487A (en) * | 2013-09-03 | 2013-12-04 | 郑州福源动物药业有限公司 | Preparing technology of stable and efficient veterinary oxytetracycline hydrochloride soluble powder |
| CN104127429A (en) * | 2014-07-28 | 2014-11-05 | 邳州正康生物技术有限公司 | Drinking water agent for preventing and treating livestock and poultry respiratory tract diseases and preparation method thereof |
-
2015
- 2015-01-29 CN CN201510044933.5A patent/CN104622811A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3639560A (en) * | 1969-07-08 | 1972-02-01 | Beecham Group Ltd | Veterinary treatment |
| CN103417487A (en) * | 2013-09-03 | 2013-12-04 | 郑州福源动物药业有限公司 | Preparing technology of stable and efficient veterinary oxytetracycline hydrochloride soluble powder |
| CN104127429A (en) * | 2014-07-28 | 2014-11-05 | 邳州正康生物技术有限公司 | Drinking water agent for preventing and treating livestock and poultry respiratory tract diseases and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 王苏华，冯群科: "复方卡那霉素可溶性粉组分含量的测定", 《兽药与饲料添加剂》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104721143A (en) * | 2015-02-13 | 2015-06-24 | 正大联合动物制药科技（江苏）有限公司 | Stable and efficient chlortetracycline hydrochloride soluble powder for livestock and preparation technology thereof |
| CN105997924A (en) * | 2016-07-07 | 2016-10-12 | 驻马店华中正大有限公司 | Chlortetracycline hydrochloride effervescent tablets and preparation method thereof |
| CN106420620A (en) * | 2016-09-28 | 2017-02-22 | 重庆大学 | Aureomycin mesilate soluble powder and preparation method thereof |
| CN107951843A (en) * | 2017-12-29 | 2018-04-24 | 浦城正大生化有限公司 | A kind of aureomycin hydrochloride soluble powder and preparation method thereof |
| CN107951843B (en) * | 2017-12-29 | 2020-09-29 | 浦城正大生化有限公司 | Chlortetracycline hydrochloride soluble powder and preparation method thereof |
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Application publication date: 20150520 |
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