CN104721143A - Stable and efficient chlortetracycline hydrochloride soluble powder for livestock and preparation technology thereof - Google Patents
Stable and efficient chlortetracycline hydrochloride soluble powder for livestock and preparation technology thereof Download PDFInfo
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- CN104721143A CN104721143A CN201510077595.5A CN201510077595A CN104721143A CN 104721143 A CN104721143 A CN 104721143A CN 201510077595 A CN201510077595 A CN 201510077595A CN 104721143 A CN104721143 A CN 104721143A
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- chlortetracycline hydrochloride
- soluble powder
- sodium lauryl
- chlortetracycline
- lauryl sulphate
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Abstract
The invention discloses stable and efficient chlortetracycline hydrochloride soluble powder for livestock and a preparation technology thereof. The powder mainly comprises the following raw materials in percentage by weight: 10-15 percent of chlortetracycline hydrochloride, 0.2-3.0 percent of lauryl sodium sulfate, 0.1-1.0 percent of ethylenediamine tetraacetic acid disodium and anhydrous dextrose in balancing amount. The raw materials are crushed and screened respectively, and then are fully and uniformly mixed by an equivalent incremental method. According to the powder, chlortetracycline hydrochloride is adopted as a raw material, lauryl sodium sulfate is added as an absorption promoter, and ethylenediamine tetraacetic acid disodium salt is added as an antioxidant and a chelating agent, so that the stability and high efficiency of the chlortetracycline hydrochloride soluble powder are guaranteed.
Description
Technical field
The present invention relates to a kind of chlortetracycline hydrochloride soluble powder, particularly relate to a kind of chlortetracycline hydrochloride soluble powder for animals and preparation technology thereof of stability and high efficiency.
Background technology
At present, chlortetracycline hydrochloride soluble powder for animals on sale on market, because chlortetracycline is unstable, be easy to oxidation, variable color, has a significant impact the stability of preparation and therapeutic effect, therefore urgently develops a kind of chlortetracycline hydrochloride soluble powder and preparation technology of stability and high efficiency.
Summary of the invention
For above-mentioned existing technical problem, the invention provides a kind of chlortetracycline hydrochloride soluble powder for animals and preparation technology thereof of stability and high efficiency, to reach efficient, stable, to absorb object that is fast and use safety.
For achieving the above object, the chlortetracycline hydrochloride soluble powder for animals of this stability and high efficiency, forms primarily of following raw material: chlortetracycline hydrochloride 10-50% by weight percentage, sodium lauryl sulphate salt 0.2-3.0%, disodiumedetate 0.1-1.0%, surplus is anhydrous glucose.
Preferably, raw materials by weight comprises: chlortetracycline hydrochloride 20-50%, sodium lauryl sulphate salt 0.3-2.5%, disodiumedetate 0.2-0.8%, and surplus is anhydrous glucose.
Optimum, raw materials by weight comprises: chlortetracycline hydrochloride 20%, sodium lauryl sulphate salt 2%, disodiumedetate 0.6%, and surplus is anhydrous glucose.
The preparation technology of the chlortetracycline hydrochloride soluble powder for animals of this stability and high efficiency, comprises the steps: A, chlortetracycline hydrochloride, sodium lauryl sulphate salt, disodiumedetate, anhydrous glucose is pulverized and sieved respectively;
B, get chlortetracycline hydrochloride by weight percentage, sodium lauryl sulphate salt, disodium EDTA, anhydrous glucose, fully mix 0.5 hour-1.5 hours, after mix homogeneously with equal increments method, obtain this product.
The present invention adopts chlortetracycline hydrochloride to be raw material, add sodium lauryl sulphate salt as absorption enhancer, it is dissolve intestinal mucosa composition that sodium lauryl sulphate urgees mechanism of absorption, release protein and phospholipid, affect the activity of lactic acid dehydrogenase and mitochondrion lactic acid dehydrogenase, there is powerful short absorption effect; Add again disodium EDTA as antioxidant and chelating agen, disodium EDTA can with Ca
2+sequestration also reduces extracellular Ca
2+concentration, makes the outer Ca of dependent cells
2+the compact siro spinning technology of concentration is opened, and increases cell traffic and promotes drug absorption, can reduce Ca simultaneously
2+, Mg
2+deng the interference effect that metal ion absorbs chlortetracycline, improve absorbance and the bioavailability of chlortetracycline principal agent.
So, just can ensure stability and the high efficiency of chlortetracycline hydrochloride soluble powder, overcome prior art produce chlortetracycline hydrochloride soluble powder product instability and and absorbance low wait deficiency.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described.
The present invention's chlortetracycline hydrochloride soluble powder for animals, in order to ensure the stable of preparation and absorb high efficiency, in raw material chlortetracycline hydrochloride, add sodium lauryl sulphate salt as absorption enhancer, to improve medicine absorption strength in vivo, add disodium EDTA as antioxidant and chelating agen simultaneously, prevent chlortetracycline hydrochloride oxidation stain, and improving medicine stability in vivo, all the other are anhydrous glucose.
During concrete making, first chlortetracycline hydrochloride, sodium lauryl sulphate salt, disodium EDTA, anhydrous glucose are pulverized respectively, sieving for standby, then select different percentage by weight preparations.
Embodiment 1: first take the chlortetracycline hydrochloride 10kg after sieving, sodium lauryl sulphate salt 0.2kg, disodium EDTA 0.1kg, anhydrous glucose 89.7kg, after fully mixing 0.5 hour with equal increments method again, obtain the chlortetracycline hydrochloride soluble powder for animals of efficient stable of the present invention.
Embodiment 2: first take the chlortetracycline hydrochloride 15kg after sieving, sodium lauryl sulphate salt 0.3kg, disodium EDTA 0.2kg, anhydrous glucose 84.5kg, after fully mixing 0.8 hour with equal increments method again, obtain this chlortetracycline hydrochloride soluble powder.
Embodiment 3: first take the chlortetracycline hydrochloride 20kg after sieving, sodium lauryl sulphate salt 2kg, disodium EDTA 0.6kg, anhydrous glucose 77.4kg, then after fully mixing 1 hour with equal increments method, obtain this chlortetracycline hydrochloride soluble powder.
Embodiment 4: first take the chlortetracycline hydrochloride 30kg after sieving, sodium lauryl sulphate salt 0.3kg, disodium EDTA 0.2kg, anhydrous glucose 69.5kg, after fully mixing 1.2 hours with equal increments method again, obtain this chlortetracycline hydrochloride soluble powder.
Embodiment 5: first take the chlortetracycline hydrochloride 40kg after sieving, sodium lauryl sulphate salt 2.5kg, disodium EDTA 0.8kg, anhydrous glucose 56.7kg, after fully mixing 1.4 hours with equal increments method again, obtain this chlortetracycline hydrochloride soluble powder.
Embodiment 6: first take the chlortetracycline hydrochloride 50kg after sieving, sodium lauryl sulphate salt 3kg, disodium EDTA 1kg, anhydrous glucose 46kg, then after fully mixing 1.5 hours with equal increments method, obtain this chlortetracycline hydrochloride soluble powder.
Claims (4)
1. the chlortetracycline hydrochloride soluble powder for animals of a stability and high efficiency, it is characterized in that, form primarily of following raw material by weight percentage: chlortetracycline hydrochloride 10-50%, sodium lauryl sulphate salt 0.2-3.0%, disodiumedetate 0.1-1.0%, surplus is anhydrous glucose.
2. the chlortetracycline hydrochloride soluble powder for animals of stability and high efficiency according to claim 1, it is characterized in that, form primarily of following raw material by weight percentage: chlortetracycline hydrochloride 20-50%, sodium lauryl sulphate salt 0.3-2.5%, disodiumedetate 0.2-0.8%, surplus is anhydrous glucose.
3. the chlortetracycline hydrochloride soluble powder for animals of stability and high efficiency according to claim 2, it is characterized in that, form primarily of following raw material by weight percentage: chlortetracycline hydrochloride 20%, sodium lauryl sulphate salt 2%, disodiumedetate 0.6%, surplus is anhydrous glucose.
4. the preparation technology of the chlortetracycline hydrochloride soluble powder for animals of an a kind of stability and high efficiency as claimed in claim 1, it is characterized in that, comprise the steps: A, chlortetracycline hydrochloride, sodium lauryl sulphate salt, disodiumedetate, anhydrous glucose are pulverized and sieved respectively;
B, get chlortetracycline hydrochloride by weight percentage, sodium lauryl sulphate salt, disodium EDTA, anhydrous glucose, fully mix 0.5 hour-1.5 hours, after mix homogeneously with equal increments method, obtain this product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510077595.5A CN104721143A (en) | 2015-02-13 | 2015-02-13 | Stable and efficient chlortetracycline hydrochloride soluble powder for livestock and preparation technology thereof |
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| CN201510077595.5A CN104721143A (en) | 2015-02-13 | 2015-02-13 | Stable and efficient chlortetracycline hydrochloride soluble powder for livestock and preparation technology thereof |
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| CN104721143A true CN104721143A (en) | 2015-06-24 |
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| CN201510077595.5A Pending CN104721143A (en) | 2015-02-13 | 2015-02-13 | Stable and efficient chlortetracycline hydrochloride soluble powder for livestock and preparation technology thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105267977A (en) * | 2015-11-11 | 2016-01-27 | 郑州后羿制药有限公司 | Dissolvable doxycycline powder and preparation method thereof |
| CN106420620A (en) * | 2016-09-28 | 2017-02-22 | 重庆大学 | Aureomycin mesilate soluble powder and preparation method thereof |
| CN111388498A (en) * | 2020-03-23 | 2020-07-10 | 山东迅达康兽药有限公司 | Spectinolincomycin hydrochloride soluble powder capable of being mutually dissolved with oil seedlings after being dissolved in water and preparation method thereof |
| CN112957481A (en) * | 2021-04-26 | 2021-06-15 | 佛山市南海东方澳龙制药有限公司 | Insoluble drug inclusion compound, inclusion method and chlortetracycline hydrochloride soluble powder |
| CN114917193A (en) * | 2022-05-07 | 2022-08-19 | 广东温氏大华农生物科技有限公司 | Chlortetracycline hydrochloride soluble powder suitable for complex water quality and preparation method thereof |
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| CN103284956A (en) * | 2013-01-16 | 2013-09-11 | 内蒙古金河动物药业有限公司 | Chlortetracycline premix and preparation method thereof |
| CN103417487A (en) * | 2013-09-03 | 2013-12-04 | 郑州福源动物药业有限公司 | Preparing technology of stable and efficient veterinary oxytetracycline hydrochloride soluble powder |
| CN104622811A (en) * | 2015-01-29 | 2015-05-20 | 邳州正康生物技术有限公司 | Formula of veterinary chlortetracycline hydrochloride soluble powder and preparation method thereof |
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| CN103263400A (en) * | 2013-01-16 | 2013-08-28 | 内蒙古金河动物药业有限公司 | Chlortetracycline microcapsule preparation and preparation method thereof |
| CN103284956A (en) * | 2013-01-16 | 2013-09-11 | 内蒙古金河动物药业有限公司 | Chlortetracycline premix and preparation method thereof |
| CN103417487A (en) * | 2013-09-03 | 2013-12-04 | 郑州福源动物药业有限公司 | Preparing technology of stable and efficient veterinary oxytetracycline hydrochloride soluble powder |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105267977A (en) * | 2015-11-11 | 2016-01-27 | 郑州后羿制药有限公司 | Dissolvable doxycycline powder and preparation method thereof |
| CN105267977B (en) * | 2015-11-11 | 2018-09-07 | 河南后羿实业集团有限公司 | A kind of Doxycycline soluble powder and preparation method thereof |
| CN106420620A (en) * | 2016-09-28 | 2017-02-22 | 重庆大学 | Aureomycin mesilate soluble powder and preparation method thereof |
| CN111388498A (en) * | 2020-03-23 | 2020-07-10 | 山东迅达康兽药有限公司 | Spectinolincomycin hydrochloride soluble powder capable of being mutually dissolved with oil seedlings after being dissolved in water and preparation method thereof |
| CN111388498B (en) * | 2020-03-23 | 2021-03-16 | 山东迅达康兽药有限公司 | Spectinolincomycin hydrochloride soluble powder capable of being mutually dissolved with oil seedlings after being dissolved in water and preparation method thereof |
| CN112957481A (en) * | 2021-04-26 | 2021-06-15 | 佛山市南海东方澳龙制药有限公司 | Insoluble drug inclusion compound, inclusion method and chlortetracycline hydrochloride soluble powder |
| CN114917193A (en) * | 2022-05-07 | 2022-08-19 | 广东温氏大华农生物科技有限公司 | Chlortetracycline hydrochloride soluble powder suitable for complex water quality and preparation method thereof |
| CN114917193B (en) * | 2022-05-07 | 2023-05-30 | 广东温氏大华农生物科技有限公司 | Aureomycin hydrochloride soluble powder suitable for complex water quality and preparation method thereof |
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