CN105997924A - Chlortetracycline hydrochloride effervescent tablets and preparation method thereof - Google Patents
Chlortetracycline hydrochloride effervescent tablets and preparation method thereof Download PDFInfo
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- CN105997924A CN105997924A CN201610531003.7A CN201610531003A CN105997924A CN 105997924 A CN105997924 A CN 105997924A CN 201610531003 A CN201610531003 A CN 201610531003A CN 105997924 A CN105997924 A CN 105997924A
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- Prior art keywords
- chlortetracycline hydrochloride
- effervescent tablet
- chlortetracycline
- acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to chlortetracycline hydrochloride effervescent tablets. The chlortetracycline hydrochloride effervescent tablets are prepared from, by weight, 5%-30% of chlortetracycline hydrochloride, 5%-25% of tartaric acid, 5%-25% of sodium bicarbonate, 1%-15% of soluble starch, 1%-10% of microcrystalline cellulose, 1%-50% of anhydrous dextrose and 1%-30% of nicotinamide. Compared with traditional soluble chlortetracycline hydrochloride powder, the chlortetracycline hydrochloride effervescent tablet product is good in solubility, better in therapeutic effect and convenient to use, and the phenomena such as wall sticking and dust are reduced.
Description
Technical field
The invention belongs to chlortetracycline hydrochloride preparation technique field, be specifically related to formula of a kind of novel chlortetracycline hydrochloride effervescent tablet products and preparation method thereof.
Background technology
Chlortetracycline hydrochloride, calls Chlortetracycline, and the same tetracycline of its antimicrobial spectrum, to penicillin resistant, the curative effect of staphylococcus aureus is stronger than tetracycline.Now it is mainly used in treating conjunctivitis, trachoma etc..At present, chlortetracycline hydrochloride common formulations for animals on sale on market is mainly soluble powder, owing to chlortetracycline is unstable, it is prone to oxidation, variable color, stability and therapeutic effect impact on preparation are relatively big, the most urgently develop a kind of novel stabilising efficient chlortetracycline hydrochloride product.
Summary of the invention
Present invention aim to overcome that prior art defect, it is provided that a kind of novel chlortetracycline hydrochloride effervescent tablet products and preparation method thereof.
For achieving the above object, the present invention adopts the following technical scheme that
A kind of chlortetracycline hydrochloride effervescent tablet, it includes following components in percentage by weight: chlortetracycline hydrochloride 5-30%, tartaric acid 5-25%, sodium bicarbonate 5-25%, soluble starch 1-15%, microcrystalline Cellulose 1-10%, anhydrous glucose 1-50% and nicotiamide 1-30%.
The preparation method of above-mentioned chlortetracycline hydrochloride effervescent tablet, it comprises the steps:
1) raw material prepares: take each raw material in proportion, wherein soluble starch, anhydrous glucose and nicotiamide are divided into two parts, a copy of it and chlortetracycline hydrochloride, tartaric acid mix homogeneously obtain acid material, and additionally a and sodium bicarbonate mix homogeneously obtains alkaline material;
2) pelletize: above-mentioned acid material and alkaline material are separately added in granulator granulation and obtain acid particles and alkali grain, drying, sieve, take the 60 above granules of mesh standby;
3) tabletting: acid particles and alkali grain are sufficiently mixed uniformly with microcrystalline Cellulose, tablet machine tabletted, obtain chlortetracycline hydrochloride effervescent tablet finished product, available aluminium foil bag vacuum packaging.
In effervescent tablet formula of the present invention, chlortetracycline hydrochloride is that medicinal ingredient, tartaric acid and sodium bicarbonate are used as effervescent, and soluble starch is used as binding agent, and microcrystalline Cellulose is used as disintegrating agent, anhydrous glucose and nicotiamide and is used as filler;Common commercially available prod all can directly be bought by raw material in formula.Compared with traditional chlortetracycline hydrochloride soluble powder, chlortetracycline hydrochloride effervescent tablet products dissolubility of the present invention is good, therapeutic effect more preferable, and easy to use, reduces the generation being stained with the phenomenon such as wall, dust.
Compared to the prior art, beneficial effects of the present invention:
Compared to soluble powder, the characteristic of Aquatic product anger bubble met by chlortetracycline hydrochloride effervescent tablet of the present invention, can save manual stirring step, and solution is more uniform, thus play therapeutical effect larger;During preparing effervescent tablet, acid material is pelletized respectively with alkaline material, it is to avoid directly contacts, improves its stability;Tablet is stained with wall, is played the shortcomings such as dirt during can avoiding using;Fill anhydrous glucose, nicotiamide can as energy, vitamin supplement, improve curative effect.Being experimentally verified that, the chlortetracycline hydrochloride effervescent tablet therapeutic effect of the present invention is significantly better than traditional chlortetracycline hydrochloride soluble powder.
Detailed description of the invention
Below in conjunction with embodiment, technical scheme is discussed in detail further, but protection scope of the present invention is not limited thereto.
Embodiment
1
A kind of chlortetracycline hydrochloride effervescent tablet, it includes following components in percentage by weight: chlortetracycline hydrochloride 5%, tartaric acid 10%, sodium bicarbonate 15%, soluble starch 5%, microcrystalline Cellulose 5%, anhydrous glucose 40% and nicotiamide 20%.
The preparation method of above-mentioned chlortetracycline hydrochloride effervescent tablet, it comprises the steps:
1) raw material prepares: take each raw material in proportion, wherein soluble starch, anhydrous glucose and nicotiamide are divided into two parts, a copy of it and chlortetracycline hydrochloride, tartaric acid mix homogeneously obtain acid material, and additionally a and sodium bicarbonate mix homogeneously obtains alkaline material;
2) pelletize: above-mentioned acid material and alkaline material are separately added in one-step-granulating method granulation and obtain acid particles and alkali grain, drying, sieve, take the 60 above granules of mesh standby;
3) tabletting: acid particles and alkali grain are sufficiently mixed uniformly with microcrystalline Cellulose, tablet machine tabletted, obtain chlortetracycline hydrochloride effervescent tablet finished product (every weighs about 1.5g), be vacuum-packed with aluminium foil bag.
Embodiment
2
A kind of chlortetracycline hydrochloride effervescent tablet, it includes following components in percentage by weight: chlortetracycline hydrochloride 15%, tartaric acid 20%, sodium bicarbonate 8%, soluble starch 10%, microcrystalline Cellulose 8%, anhydrous glucose 27% and nicotiamide 12%.
The preparation method of above-mentioned chlortetracycline hydrochloride effervescent tablet, with reference to embodiment 1.
Embodiment
3
A kind of chlortetracycline hydrochloride effervescent tablet, it includes following components in percentage by weight: chlortetracycline hydrochloride 25%, tartaric acid 15%, sodium bicarbonate 20%, soluble starch 15%, microcrystalline Cellulose 10%, anhydrous glucose 10% and nicotiamide 5%.
The preparation method of above-mentioned chlortetracycline hydrochloride effervescent tablet, with reference to embodiment 1.
Application examples
1
Observation of curative effect with effervescent tablet of the present invention treatment broiler colibacillosis:
Laboratory animal: 60 yellow-feather broilers, confirmed suffer from colibacillosis.Clinical criteria: sick chicken lassitude, peels off slow-witted vertical, spirit is depressed, close one's eyes, necking down of bowing, feather pine unrest and wing is sagging, be reluctant activity, drink water, searching for food significantly reduces, and has obvious respiratory symptom, the sick clavus of part is shed tears, and swollen eye arranges yellow-white loose stool.
Experimental technique: the broiler that diagnosis suffers from colibacillosis is randomly divided into experimental group and matched group, experimental group 30, matched group 30.The Therapeutic Method that experimental group broiler uses is the chlortetracycline hydrochloride effervescent tablet 5 taking the embodiment of the present invention 1, is placed directly within 5L water, freely drinks water;Matched group broiler Therapeutic Method is: takes 7.5g chlortetracycline hydrochloride soluble powder, is dissolved in 5L clear water, freely drinks water.
Curative effect diagnostic criteria: (1) fully recovers: clinical symptoms is wholly absent;(2) effective: clinical symptom relief, but be not wholly absent;(3) invalid: clinical symptoms is without significant change, and the state of an illness has no and alleviates, even occur deteriorating.
Experimental result is shown in Table 1: experimental group treatment cure rate is 86.7%, higher by 20.0% than matched group;Experimental group treatment total effective rate is 100%, higher by 16.7% than matched group.
The clinical treatment outcome of table 1 broiler colibacillosis experiment
As can be seen here, comparing with traditional soluble powder, use effervescent tablet of the present invention treatment broiler colibacillosis effective, cure rate and total effective rate are high.
Application examples
2
Observation of curative effect with effervescent tablet of the present invention treatment broiler chronic respiratory tract disease
Laboratory animal: 60 yellow-feather broilers, confirmed suffer from chronic respiratory tract disease.Clinical criteria: sick chicken dyspnea, hat whisker sends out and starts, and mouth breathing, cough has trachea gong sound, lassitude, loss of appetite. growth retardation. and eye conjunctiva inflammation, shed tears. eyelid swelled. having caseous exudate in eye socket, severe patient one or both sides are blind.
Experimental technique: diagnosis is suffered from chronic respiratory tract disease broiler and is randomly divided into experimental group and matched group, experimental group 30, matched group 30.The Therapeutic Method that experimental group broiler uses is the chlortetracycline hydrochloride effervescent tablet 5 taking the embodiment of the present invention 2, is placed directly within 5L water, freely drinks water;Matched group broiler Therapeutic Method is: takes 7.5g chlortetracycline hydrochloride soluble powder, is dissolved in 5L clear water, freely drinks water.
Curative effect diagnostic criteria: (1) fully recovers: clinical symptoms is wholly absent;(2) effective: clinical symptom relief, but be not wholly absent;(3) invalid: clinical symptoms is without significant change, and the state of an illness has no and alleviates, even occur deteriorating.
Experimental result is shown in Table 2: experimental group treatment cure rate is 90.0%, higher by 16.7% than matched group, and experimental group treatment total effective rate is 100%, higher by 10.0% than matched group.
The clinical treatment outcome of table 2 broiler chronic respiratory tract disease experiment
As can be seen here, comparing with traditional soluble powder, use effervescent tablet of the present invention treatment broiler chronic respiratory tract disease effective, cure rate and total effective rate are high.
Application examples
3
With the somatotrophic observation of curative effect of effervescent tablet of the present invention
Laboratory animal: 2000 yellow-feather broilers, confirmed healthy without disease.
Experimental technique: health broiler is randomly divided into experimental group and matched group, experimental group 1000, matched group 1000.The Therapeutic Method that experimental group broiler uses is the chlortetracycline hydrochloride effervescent tablet 1 taking the embodiment of the present invention 3, is placed directly within 5L water, freely drinks water;Matched group broiler Therapeutic Method is: takes 1.5g chlortetracycline hydrochloride soluble powder, is dissolved in 5L clear water, freely drinks water.
Curative effect diagnostic criteria: (1) survival rate;(2) average weight;(3) feedstuff-meat ratio
Experimental result is shown in Table 3: experimental group survival rate is 95.3%, higher by 4.9% than matched group, and experimental group feedstuff-meat ratio is 1.698, lower by 1.94% than matched group.
The clinical treatment outcome of table 3 broiler growth promotion experiment
As can be seen here, comparing with traditional soluble powder, effervescent tablet of the present invention can remarkably promote growth of meat chicken, and using effect is good, and economic benefit is obvious.
Claims (2)
1. a chlortetracycline hydrochloride effervescent tablet, it is characterized in that, including following components in percentage by weight: chlortetracycline hydrochloride 5-30%, tartaric acid 5-25%, sodium bicarbonate 5-25%, soluble starch 1-15%, microcrystalline Cellulose 1-10%, anhydrous glucose 1-50% and nicotiamide 1-30%.
2. the preparation method of chlortetracycline hydrochloride effervescent tablet described in claim 1, it is characterised in that comprise the steps:
1) raw material prepares: take each raw material in proportion, wherein soluble starch, anhydrous glucose and nicotiamide are divided into two parts, a copy of it and chlortetracycline hydrochloride, tartaric acid mix homogeneously obtain acid material, and additionally a and sodium bicarbonate mix homogeneously obtains alkaline material;
2) pelletize: above-mentioned acid material and alkaline material are separately added in granulator granulation and obtain acid particles and alkali grain, be dried, sieve, take the 60 above granules of mesh standby;
3) tabletting: acid particles and alkali grain are mixed homogeneously with microcrystalline Cellulose, tablet machine tabletted, to obtain final product.
Priority Applications (1)
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CN201610531003.7A CN105997924A (en) | 2016-07-07 | 2016-07-07 | Chlortetracycline hydrochloride effervescent tablets and preparation method thereof |
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CN201610531003.7A CN105997924A (en) | 2016-07-07 | 2016-07-07 | Chlortetracycline hydrochloride effervescent tablets and preparation method thereof |
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CN201610531003.7A Pending CN105997924A (en) | 2016-07-07 | 2016-07-07 | Chlortetracycline hydrochloride effervescent tablets and preparation method thereof |
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Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB794798A (en) * | 1955-09-22 | 1958-05-07 | Nathaniel Mandel Elias | Pharmaceutical compositions |
EP0205336A2 (en) * | 1985-06-11 | 1986-12-17 | Teijin Limited | Oral sustained release pharmaceutical preparation |
CN102133206A (en) * | 2011-03-21 | 2011-07-27 | 郑州百瑞动物药业有限公司 | Oxytetracycline hydrochloride effervescent tablet for dairy cattle and preparation method thereof |
CN102283864A (en) * | 2011-07-28 | 2011-12-21 | 陕西科技大学 | Donkey-hide gelatin effervescent tablets and preparation method thereof |
CN102389116A (en) * | 2011-11-23 | 2012-03-28 | 武汉工程大学 | Effervescent tablet for alleviating physical fatigue and preparation technology thereof |
CN102600184A (en) * | 2012-03-02 | 2012-07-25 | 山东胜利股份有限公司 | Veterinary-use intestinal targeted antibacterial pellet and preparation method thereof |
CN104351501A (en) * | 2014-10-11 | 2015-02-18 | 江苏省家禽科学研究所 | Feed for improving feeding welfare quality of yellow feather broilers as well as production method and feeding method |
CN104622811A (en) * | 2015-01-29 | 2015-05-20 | 邳州正康生物技术有限公司 | Formula of veterinary chlortetracycline hydrochloride soluble powder and preparation method thereof |
-
2016
- 2016-07-07 CN CN201610531003.7A patent/CN105997924A/en active Pending
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB794798A (en) * | 1955-09-22 | 1958-05-07 | Nathaniel Mandel Elias | Pharmaceutical compositions |
EP0205336A2 (en) * | 1985-06-11 | 1986-12-17 | Teijin Limited | Oral sustained release pharmaceutical preparation |
CN102133206A (en) * | 2011-03-21 | 2011-07-27 | 郑州百瑞动物药业有限公司 | Oxytetracycline hydrochloride effervescent tablet for dairy cattle and preparation method thereof |
CN102283864A (en) * | 2011-07-28 | 2011-12-21 | 陕西科技大学 | Donkey-hide gelatin effervescent tablets and preparation method thereof |
CN102389116A (en) * | 2011-11-23 | 2012-03-28 | 武汉工程大学 | Effervescent tablet for alleviating physical fatigue and preparation technology thereof |
CN102600184A (en) * | 2012-03-02 | 2012-07-25 | 山东胜利股份有限公司 | Veterinary-use intestinal targeted antibacterial pellet and preparation method thereof |
CN104351501A (en) * | 2014-10-11 | 2015-02-18 | 江苏省家禽科学研究所 | Feed for improving feeding welfare quality of yellow feather broilers as well as production method and feeding method |
CN104622811A (en) * | 2015-01-29 | 2015-05-20 | 邳州正康生物技术有限公司 | Formula of veterinary chlortetracycline hydrochloride soluble powder and preparation method thereof |
Non-Patent Citations (2)
Title |
---|
《制剂工艺》 * |
《淮海工学院学报》 * |
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Application publication date: 20161012 |