CN104610257A - FXa inhibitor containing amide structure as well as preparation method and application thereof - Google Patents
FXa inhibitor containing amide structure as well as preparation method and application thereof Download PDFInfo
- Publication number
- CN104610257A CN104610257A CN201510082543.7A CN201510082543A CN104610257A CN 104610257 A CN104610257 A CN 104610257A CN 201510082543 A CN201510082543 A CN 201510082543A CN 104610257 A CN104610257 A CN 104610257A
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- CN
- China
- Prior art keywords
- compound
- fxa inhibitor
- preparation
- formula
- obtains
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Compound | IC 50(nM) |
Edoxaban | 4.0 |
Compound I-1 | 7.8 |
Compound I-2 | 3.5 |
Compound I-3 | 3.9 |
Compound I-4 | 5.3 |
Compound I-5 | 6.9 |
Compound I-6 | 4.4 |
Compound I-7 | 6.2 |
Compound I-8 | 8.1 |
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510082543.7A CN104610257B (en) | 2015-02-14 | 2015-02-14 | The FXa inhibitor of one class amide containing structure, preparation method and its usage |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510082543.7A CN104610257B (en) | 2015-02-14 | 2015-02-14 | The FXa inhibitor of one class amide containing structure, preparation method and its usage |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104610257A true CN104610257A (en) | 2015-05-13 |
CN104610257B CN104610257B (en) | 2016-06-01 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN201510082543.7A Active CN104610257B (en) | 2015-02-14 | 2015-02-14 | The FXa inhibitor of one class amide containing structure, preparation method and its usage |
Country Status (1)
Country | Link |
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CN (1) | CN104610257B (en) |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1420882A (en) * | 1999-07-28 | 2003-05-28 | 阿温蒂斯药物公司 | Substd. oxoazaheterocyclyl compounds |
WO2006107963A2 (en) * | 2005-04-06 | 2006-10-12 | Novartis Ag | Process for preparing dipeptide amides |
WO2008065503A1 (en) * | 2006-11-29 | 2008-06-05 | Pfizer Products Inc. | (r) -5-methyl-4, 5-dihydro- pyrazole-1, 5-dicarboxylic acid 1- [ ( 4 -chlorophenyl) amide 5-{ [2-fluoro-4- (2-oxo-2h-pyridin-1-yl) -phenyl]amide) as a factor xa inhibitor |
WO2009013299A2 (en) * | 2007-07-25 | 2009-01-29 | Boehringer Ingelheim International Gmbh | Novel bradykinin b1 antagonists |
CN102464658A (en) * | 2010-11-03 | 2012-05-23 | 天津药物研究院 | Oxazolidinone derivative and preparation method and application thereof |
-
2015
- 2015-02-14 CN CN201510082543.7A patent/CN104610257B/en active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1420882A (en) * | 1999-07-28 | 2003-05-28 | 阿温蒂斯药物公司 | Substd. oxoazaheterocyclyl compounds |
WO2006107963A2 (en) * | 2005-04-06 | 2006-10-12 | Novartis Ag | Process for preparing dipeptide amides |
WO2008065503A1 (en) * | 2006-11-29 | 2008-06-05 | Pfizer Products Inc. | (r) -5-methyl-4, 5-dihydro- pyrazole-1, 5-dicarboxylic acid 1- [ ( 4 -chlorophenyl) amide 5-{ [2-fluoro-4- (2-oxo-2h-pyridin-1-yl) -phenyl]amide) as a factor xa inhibitor |
WO2009013299A2 (en) * | 2007-07-25 | 2009-01-29 | Boehringer Ingelheim International Gmbh | Novel bradykinin b1 antagonists |
CN102464658A (en) * | 2010-11-03 | 2012-05-23 | 天津药物研究院 | Oxazolidinone derivative and preparation method and application thereof |
Non-Patent Citations (2)
Title |
---|
SAE-KWANG KU等: "Antithrombotic activities of pellitorine in vitro and in vivo", 《FITOTERAPIA》, vol. 91, 22 August 2013 (2013-08-22), pages 1 - 8 * |
邢俊豪等: "抗血栓药物的研究进展", 《药学进展》, vol. 38, no. 3, 25 March 2014 (2014-03-25), pages 174 - 184 * |
Also Published As
Publication number | Publication date |
---|---|
CN104610257B (en) | 2016-06-01 |
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Legal Events
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: FXa inhibitor containing amide structure as well as preparation method and application thereof Effective date of registration: 20170816 Granted publication date: 20160601 Pledgee: Guangdong Nanhai Rural Commercial Bank branch branch of Limited by Share Ltd Pledgor: FOSHAN SAIWEISI PHARMACEUTICAL TECHNOLOGY CO., LTD. Registration number: 2017990000756 |
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PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20190604 Granted publication date: 20160601 Pledgee: Guangdong Nanhai Rural Commercial Bank branch branch of Limited by Share Ltd Pledgor: FOSHAN SAIWEISI PHARMACEUTICAL TECHNOLOGY CO., LTD. Registration number: 2017990000756 |
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TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20190807 Address after: 233000 Yuhui District, Bengbu City, Anhui Province, No. 1750 Shengli West Road, No. 316 Pioneering Building, Huineng Small and Micro Enterprise Pioneering Center Patentee after: Bengbu Dingrong Science and Technology Information Consulting Co., Ltd. Address before: Chancheng district has 528000 Taiwan public in Guangdong province Foshan City No. 32 first floor 1636, shop No. 1637 Patentee before: FOSHAN SAIWEISI PHARMACEUTICAL TECHNOLOGY CO., LTD. |