CN104557929B - One class contains coagulation factor xa inhibitors and the purposes thereof of bicyclic amide structure - Google Patents
One class contains coagulation factor xa inhibitors and the purposes thereof of bicyclic amide structure Download PDFInfo
- Publication number
- CN104557929B CN104557929B CN201510083411.6A CN201510083411A CN104557929B CN 104557929 B CN104557929 B CN 104557929B CN 201510083411 A CN201510083411 A CN 201510083411A CN 104557929 B CN104557929 B CN 104557929B
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- compound
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- present
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- inhibitors
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- 0 *C(CCC1)C[C@]2[C@@]1(N)NCCC2 Chemical compound *C(CCC1)C[C@]2[C@@]1(N)NCCC2 0.000 description 4
- JDCNIUJWLNZLIY-ZJUUUORDSA-N O=C(c1ccc[s]1)N1[C@@H](CNC2)[C@@H]2CCC1 Chemical compound O=C(c1ccc[s]1)N1[C@@H](CNC2)[C@@H]2CCC1 JDCNIUJWLNZLIY-ZJUUUORDSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
Description
Compound | IC50(nM) |
Edoxaban | 3.9 |
Reference compound D-1 | 6.5 |
The compounds of this invention I-1 | 3.6 |
The compounds of this invention I-2 | 4.3 |
Claims (3)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510083411.6A CN104557929B (en) | 2015-02-14 | 2015-02-14 | One class contains coagulation factor xa inhibitors and the purposes thereof of bicyclic amide structure |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510083411.6A CN104557929B (en) | 2015-02-14 | 2015-02-14 | One class contains coagulation factor xa inhibitors and the purposes thereof of bicyclic amide structure |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104557929A CN104557929A (en) | 2015-04-29 |
CN104557929B true CN104557929B (en) | 2016-06-01 |
Family
ID=53075095
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510083411.6A Active CN104557929B (en) | 2015-02-14 | 2015-02-14 | One class contains coagulation factor xa inhibitors and the purposes thereof of bicyclic amide structure |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN104557929B (en) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1420882A (en) * | 1999-07-28 | 2003-05-28 | 阿温蒂斯药物公司 | Substd. oxoazaheterocyclyl compounds |
CN101309919A (en) * | 2005-11-16 | 2008-11-19 | 弗·哈夫曼-拉罗切有限公司 | Novel pyrrolidine derivatives as inhibitors of coagulation factor XA |
CN103242310A (en) * | 2012-02-10 | 2013-08-14 | 苏州迈泰生物技术有限公司 | Pyrazolo pyridone compound and its application in preparation of anticoagulant |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2493875B1 (en) * | 2009-10-27 | 2014-08-06 | Boehringer Ingelheim International GmbH | Heterocyclic compounds as ccr1 receptor antagonists |
-
2015
- 2015-02-14 CN CN201510083411.6A patent/CN104557929B/en active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1420882A (en) * | 1999-07-28 | 2003-05-28 | 阿温蒂斯药物公司 | Substd. oxoazaheterocyclyl compounds |
CN101309919A (en) * | 2005-11-16 | 2008-11-19 | 弗·哈夫曼-拉罗切有限公司 | Novel pyrrolidine derivatives as inhibitors of coagulation factor XA |
CN103242310A (en) * | 2012-02-10 | 2013-08-14 | 苏州迈泰生物技术有限公司 | Pyrazolo pyridone compound and its application in preparation of anticoagulant |
Also Published As
Publication number | Publication date |
---|---|
CN104557929A (en) | 2015-04-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Blood coagulation factor Xa inhibitor containing bicycle-amide structure and application thereof Effective date of registration: 20170816 Granted publication date: 20160601 Pledgee: Guangdong Nanhai Rural Commercial Bank branch branch of Limited by Share Ltd Pledgor: FOSHAN SAIWEISI PHARMACEUTICAL TECHNOLOGY CO., LTD. Registration number: 2017990000756 |
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PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20190604 Granted publication date: 20160601 Pledgee: Guangdong Nanhai Rural Commercial Bank branch branch of Limited by Share Ltd Pledgor: FOSHAN SAIWEISI PHARMACEUTICAL TECHNOLOGY CO., LTD. Registration number: 2017990000756 |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20191014 Address after: No.118, block B, high tech entrepreneurship service center, Tongling Economic Development Zone, Anhui Province Patentee after: Tongwei Technology Co., Ltd. Tongling City Address before: Chancheng district has 528000 Taiwan public in Guangdong province Foshan City No. 32 first floor 1636, shop No. 1637 Patentee before: FOSHAN SAIWEISI PHARMACEUTICAL TECHNOLOGY CO., LTD. |
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TR01 | Transfer of patent right |