CN104610258B - FXa inhibitor, the preparation method and its usage of one class amide containing and methoxy benzene structure - Google Patents
FXa inhibitor, the preparation method and its usage of one class amide containing and methoxy benzene structure Download PDFInfo
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- CN104610258B CN104610258B CN201510082544.1A CN201510082544A CN104610258B CN 104610258 B CN104610258 B CN 104610258B CN 201510082544 A CN201510082544 A CN 201510082544A CN 104610258 B CN104610258 B CN 104610258B
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- China
- Prior art keywords
- compound
- preparation
- obtains
- fxa inhibitor
- formula
- Prior art date
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- 0 *C[C@@]1[C@@](*)NCCC1 Chemical compound *C[C@@]1[C@@](*)NCCC1 0.000 description 4
- KSCPLKVBWDOSAI-RQJHMYQMSA-N C1NC[C@@H]2NCCC[C@H]12 Chemical compound C1NC[C@@H]2NCCC[C@H]12 KSCPLKVBWDOSAI-RQJHMYQMSA-N 0.000 description 1
- BPCNEKWROYSOLT-UHFFFAOYSA-N C=CC(Nc1ccccc1)=O Chemical compound C=CC(Nc1ccccc1)=O BPCNEKWROYSOLT-UHFFFAOYSA-N 0.000 description 1
- SHVKGYFALXNOMN-UHFFFAOYSA-N C=[Tl]N1CC2N(CCC(Nc3ccccc3)=O)CCCC2C1 Chemical compound C=[Tl]N1CC2N(CCC(Nc3ccccc3)=O)CCCC2C1 SHVKGYFALXNOMN-UHFFFAOYSA-N 0.000 description 1
- XHUCVGNEDUNTLF-CTNGQTDRSA-N O=C(CCN1[C@@H](CN(C2)C(c3ccccc3)=O)[C@@H]2CCC1)Nc1ccccc1 Chemical compound O=C(CCN1[C@@H](CN(C2)C(c3ccccc3)=O)[C@@H]2CCC1)Nc1ccccc1 XHUCVGNEDUNTLF-CTNGQTDRSA-N 0.000 description 1
- NAVXZQVFQVSKLC-HIFRSBDPSA-N O=C(CCN1[C@@H](CNC2)[C@@H]2CCC1)Nc1ccccc1 Chemical compound O=C(CCN1[C@@H](CNC2)[C@@H]2CCC1)Nc1ccccc1 NAVXZQVFQVSKLC-HIFRSBDPSA-N 0.000 description 1
- VEOABPKBGAVJQX-JWOPXBRZSA-N [Tl]N1C[C@@H]2NCCCC2C1 Chemical compound [Tl]N1C[C@@H]2NCCCC2C1 VEOABPKBGAVJQX-JWOPXBRZSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Compound | IC 50(nM) |
Edoxaban | 4.0 |
Reference compound D-1 | 7.8 |
Compound I-1 | 3.4 |
Compound I-2 | 4.5 |
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510082544.1A CN104610258B (en) | 2015-02-14 | 2015-02-14 | FXa inhibitor, the preparation method and its usage of one class amide containing and methoxy benzene structure |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510082544.1A CN104610258B (en) | 2015-02-14 | 2015-02-14 | FXa inhibitor, the preparation method and its usage of one class amide containing and methoxy benzene structure |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104610258A CN104610258A (en) | 2015-05-13 |
CN104610258B true CN104610258B (en) | 2016-03-30 |
Family
ID=53144938
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510082544.1A Active CN104610258B (en) | 2015-02-14 | 2015-02-14 | FXa inhibitor, the preparation method and its usage of one class amide containing and methoxy benzene structure |
Country Status (1)
Country | Link |
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CN (1) | CN104610258B (en) |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR0013179A (en) * | 1999-07-28 | 2002-04-02 | Aventis Pharm Prod Inc | Substituted oxoazaeterocyclyl compounds |
WO2006006490A1 (en) * | 2004-07-08 | 2006-01-19 | Ono Pharmaceutical Co., Ltd. | Spirocyclic compound |
US7678917B2 (en) * | 2005-09-01 | 2010-03-16 | Hoffman-La Roche Inc. | Factor Xa inhibitors |
CN103936763B (en) * | 2013-01-18 | 2017-10-31 | 中国科学院上海药物研究所 | Oxazolidinone compounds and its production and use |
CN104311537B (en) * | 2014-09-19 | 2016-08-24 | 广东东阳光药业有限公司 | Containing pyrimidone acetyl substituents pyrazole compound and combinations thereof thing and purposes |
-
2015
- 2015-02-14 CN CN201510082544.1A patent/CN104610258B/en active Active
Also Published As
Publication number | Publication date |
---|---|
CN104610258A (en) | 2015-05-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: FXa inhibitor containing amide and methoxybenzene structures as well as preparation method and application thereof Effective date of registration: 20170816 Granted publication date: 20160330 Pledgee: Guangdong Nanhai Rural Commercial Bank branch branch of Limited by Share Ltd Pledgor: FOSHAN SAIWEISI PHARMACEUTICAL TECHNOLOGY CO., LTD. Registration number: 2017990000756 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20190604 Granted publication date: 20160330 Pledgee: Guangdong Nanhai Rural Commercial Bank branch branch of Limited by Share Ltd Pledgor: FOSHAN SAIWEISI PHARMACEUTICAL TECHNOLOGY CO., LTD. Registration number: 2017990000756 |
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PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20190805 Address after: 233000 Yuhui District, Bengbu City, Anhui Province, No. 1750 Shengli West Road, No. 316 Pioneering Building, Huineng Small and Micro Enterprise Pioneering Center Patentee after: Bengbu Dingrong Science and Technology Information Consulting Co., Ltd. Address before: Chancheng district has 528000 Taiwan public in Guangdong province Foshan City No. 32 first floor 1636, shop No. 1637 Patentee before: FOSHAN SAIWEISI PHARMACEUTICAL TECHNOLOGY CO., LTD. |
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TR01 | Transfer of patent right |