CN104610112A - N-苯基金刚烷酰胺类葡萄糖激酶活化剂、制备方法及其用途 - Google Patents
N-苯基金刚烷酰胺类葡萄糖激酶活化剂、制备方法及其用途 Download PDFInfo
- Publication number
- CN104610112A CN104610112A CN201510075666.8A CN201510075666A CN104610112A CN 104610112 A CN104610112 A CN 104610112A CN 201510075666 A CN201510075666 A CN 201510075666A CN 104610112 A CN104610112 A CN 104610112A
- Authority
- CN
- China
- Prior art keywords
- compound
- glucose
- glucokinase
- diabetes
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *Cc1ccc(*)cc1 Chemical compound *Cc1ccc(*)cc1 0.000 description 2
- MUDOCNDABVJUIZ-UHFFFAOYSA-N CC(C)(C)OC(NCC(NC(CC1C2)(C3)C1(C1)C2CC31c1ccccc1)=O)=O Chemical compound CC(C)(C)OC(NCC(NC(CC1C2)(C3)C1(C1)C2CC31c1ccccc1)=O)=O MUDOCNDABVJUIZ-UHFFFAOYSA-N 0.000 description 1
- LSNIXXLHXQGQID-UHFFFAOYSA-N NC(CC1C2)(C3)C1(C1)C2CC31c1ccccc1 Chemical compound NC(CC1C2)(C3)C1(C1)C2CC31c1ccccc1 LSNIXXLHXQGQID-UHFFFAOYSA-N 0.000 description 1
- AIKMHOVATLROSN-UHFFFAOYSA-N NCC(NC(CC(C1)C2)(CC1C1)CC21c1ccccc1)=O Chemical compound NCC(NC(CC(C1)C2)(CC1C1)CC21c1ccccc1)=O AIKMHOVATLROSN-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
化合物 | EC50(nM) |
化合物I-1 | 25.8 |
化合物I-2 | 11.5 |
化合物I-3 | 14.2 |
化合物I-4 | 14.9 |
化合物I-5 | 17.1 |
化合物I-6 | 18.3 |
化合物 | S0.5(mM) |
化合物I-1 | 3.6 |
化合物I-2 | 1.4 |
化合物I-3 | 2.0 |
化合物I-4 | 1.9 |
化合物I-5 | 2.5 |
化合物I-6 | 2.7 |
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510075666.8A CN104610112B (zh) | 2015-02-12 | 2015-02-12 | N-苯基金刚烷酰胺类葡萄糖激酶活化剂、制备方法及其用途 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510075666.8A CN104610112B (zh) | 2015-02-12 | 2015-02-12 | N-苯基金刚烷酰胺类葡萄糖激酶活化剂、制备方法及其用途 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104610112A true CN104610112A (zh) | 2015-05-13 |
CN104610112B CN104610112B (zh) | 2016-06-01 |
Family
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Family Applications (1)
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CN201510075666.8A Active CN104610112B (zh) | 2015-02-12 | 2015-02-12 | N-苯基金刚烷酰胺类葡萄糖激酶活化剂、制备方法及其用途 |
Country Status (1)
Country | Link |
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CN (1) | CN104610112B (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11548893B2 (en) | 2017-07-15 | 2023-01-10 | Arisan Therapeutics Inc. | Enantiomerically pure adamantane carboxamides for the treatment of filovirus infection |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1496052A1 (en) * | 2002-03-26 | 2005-01-12 | Banyu Pharmaceutical Co., Ltd. | Novel aminobenzamide derivative |
EP1532980A1 (en) * | 2003-11-24 | 2005-05-25 | Novo Nordisk A/S | N-heteroaryl indole carboxamides and analogues thereof, for use as glucokinase activators in the treatment of diabetes |
CN101218236A (zh) * | 2005-07-09 | 2008-07-09 | 阿斯利康(瑞典)有限公司 | 作为治疗2型糖尿病的葡萄糖激酶调节剂的2-杂环基氧基苯甲酰基氨基杂环化合物 |
CN101273048A (zh) * | 2005-09-30 | 2008-09-24 | 诺瓦提斯公司 | 作为葡萄糖激酶激活剂用于治疗2型糖尿病的磺酰胺衍生物 |
CN101282966A (zh) * | 2005-08-09 | 2008-10-08 | 阿斯利康(瑞典)有限公司 | 用于治疗糖尿病的杂芳基氨基甲酰基苯衍生物 |
CN101233128B (zh) * | 2005-05-27 | 2011-08-10 | 阿斯利康(瑞典)有限公司 | 在糖尿病治疗中用作glk激活剂的杂芳基苯甲酰胺衍生物 |
-
2015
- 2015-02-12 CN CN201510075666.8A patent/CN104610112B/zh active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1496052A1 (en) * | 2002-03-26 | 2005-01-12 | Banyu Pharmaceutical Co., Ltd. | Novel aminobenzamide derivative |
EP1532980A1 (en) * | 2003-11-24 | 2005-05-25 | Novo Nordisk A/S | N-heteroaryl indole carboxamides and analogues thereof, for use as glucokinase activators in the treatment of diabetes |
CN101233128B (zh) * | 2005-05-27 | 2011-08-10 | 阿斯利康(瑞典)有限公司 | 在糖尿病治疗中用作glk激活剂的杂芳基苯甲酰胺衍生物 |
CN101218236A (zh) * | 2005-07-09 | 2008-07-09 | 阿斯利康(瑞典)有限公司 | 作为治疗2型糖尿病的葡萄糖激酶调节剂的2-杂环基氧基苯甲酰基氨基杂环化合物 |
CN101282966A (zh) * | 2005-08-09 | 2008-10-08 | 阿斯利康(瑞典)有限公司 | 用于治疗糖尿病的杂芳基氨基甲酰基苯衍生物 |
CN101273048A (zh) * | 2005-09-30 | 2008-09-24 | 诺瓦提斯公司 | 作为葡萄糖激酶激活剂用于治疗2型糖尿病的磺酰胺衍生物 |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11548893B2 (en) | 2017-07-15 | 2023-01-10 | Arisan Therapeutics Inc. | Enantiomerically pure adamantane carboxamides for the treatment of filovirus infection |
Also Published As
Publication number | Publication date |
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CN104610112B (zh) | 2016-06-01 |
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C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: N-phenyl adamantane amide type glucokinase activator as well as preparation method and application thereof Effective date of registration: 20170816 Granted publication date: 20160601 Pledgee: Guangdong Nanhai Rural Commercial Bank branch branch of Limited by Share Ltd Pledgor: FOSHAN SAIWEISI PHARMACEUTICAL TECHNOLOGY CO., LTD. Registration number: 2017990000756 |
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PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20190604 Granted publication date: 20160601 Pledgee: Guangdong Nanhai Rural Commercial Bank branch branch of Limited by Share Ltd Pledgor: FOSHAN SAIWEISI PHARMACEUTICAL TECHNOLOGY CO., LTD. Registration number: 2017990000756 |
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Effective date of registration: 20190924 Address after: 221300 20 meters west of Sitian Park, Xinglou Town, Pizhou City, Jiangsu Province Patentee after: Jiangsu Tao Gou he Agricultural Technology Development Co., Ltd. Address before: Chancheng district has 528000 Taiwan public in Guangdong province Foshan City No. 32 first floor 1636, shop No. 1637 Patentee before: FOSHAN SAIWEISI PHARMACEUTICAL TECHNOLOGY CO., LTD. |