CN104606490A - Lipid lowering medicine for patients suffering from severe fat liver and preparation method of lipid lowering medicine - Google Patents

Abstract

The invention discloses a lipid lowering medicine for patients suffering from severe fat liver. The lipid lowering medicine is prepared from the following raw medicinal materials in parts by weight: 10-20 parts of fermented soybean, 15-30 parts of lotus leaf, 12-25 parts of hawthorns, 3-6 parts of centella, 5-9 parts of filliform cassytha herb, 8-12 parts of parasitic loranthus, 9-15 parts of betel nuts, 6-9 parts of frankincense, 5-10 parts of dutchmanspipe root, 10-15 parts of Caulis Spatholobi, 4-8 parts of leeches, 9-12 parts of flatstem milkvetch seed, 10-25 parts of radix polygonati officinalis and 15-30 parts of the root of red-rooted salvia. The lipid lowering medicine disclosed by the invention has the excellent effects that the traditional drug properties are organically combined with the modern pharmacology of traditional Chinese medicine, the drugs are used to form a prescription, the focus is directly reached, and the curative effect is improved; the medicine has the effects of soothing liver and strengthening spleen, clearing heat and relieving pain and lowering lipid, is exact in curative effect of severe fat liver and does not have any side effect; and moreover, the medicine source is readily available, the cost of the medicinal materials is low, and the burdens of patients can be alleviated.

Description

Severe fatty liver patient lipid lowerers and preparation method

Technical field

The present invention relates to traditional Chinese medicine field, particularly relate to a kind of severe fatty liver patient lipid lowerers and preparation method.

Background technology

In recent years, along with the change of the raising of people's living standard, life style and dietary structure, the sickness rate of fatty liver is increasing.Fatty liver is chronic hepatopathy common at present, and partial fat liver can develop into fat hepatitis, and therefore the pathological state that hepatic fibrosis and liver cirrhosis etc. are serious needs timely treatment, further develops or make it to be reversed to stop.

According to size or the storage of fat degree of Fat Distribution, iconography is divided into limitation fatty liver, diffusivity fatty liver or light, in, severe fatty liver; Clinical manifestation is blood fat especially the increasing in various degree of triglyceride, and patient is with poor appetite, abdominal distention, right flank distending pain or dull pain simultaneously, dizziness uncomfortable in chest etc.Severe fatty liver is proliferation of fibrous tissue in liver, fatty cirrhosis.So-called liver cirrhosis, refers to hepatic necrosis, and occur many fibre bundles in liver, liver metabolism is not normal, and liver surface is uneven as Fructus Momordicae charantiae.The visible hepatosplenomegaly of health check-up, and have loss of appetite, abdominal distention and upper right abdomen constriction or sensation of fullness, the sign such as weak tired out.There is no " fatty liver " this name of disease in Chinese medicine, according to characteristics of incidence and the clinical manifestation of fatty liver, modern doctor generally believes " gathering ", " hypochondriac pain ", " lump at the left hypochondrium " be the modal names of disease of tcm of fatty liver.Modern TCM etiology and pathogenesis is thought, its disease located in liver of fatty liver, although retention of phlegm and dampness is its pathogenesis, the inherence of its morbidity is liver deficiency of spleen and stomach at all.For the treatment of fatty liver, Chinese medicine, on the basis of determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, increases hepatoprotective anti-inflammatory drug, Be very effective, determined curative effect.

Application publication number CN 103656268 A(application number 201310587645.5) Chinese invention patent document disclose a kind of Chinese medicine decoction for the treatment of fatty liver, the weight portion of its constitutive material is: Flos Mume 5-7, Fructus Rosae Laevigatae 3-5, Herba Cistanches 7-8, Herb Gynostemmae Pentaphylli 3-5, Semen Cassiae 8-10, Rhizoma Polygonati 5-6, Fructus Lycii 3-5, Fructus Sechii edulis 6-8, Fructus Gleditsia 3-4, Cortex Moutan 5-7, Semen Ziziphi Spinosae 10-12, Herba Artemisiae Scopariae 4-6, Herba Taraxaci 3-5, Radix Semiaquilegiae 2-4, Testa Viciae fabae 8-9, Herba Hyperici Japonici 6-8, Herba cynodontis 2-3, Herba Lobeliae Chinensis 1-2 and bracketplant 2-4.Application publication number CN 104274610 A(application number 201410595677.4) Chinese invention patent document disclose a kind of Chinese medicine composition for the treatment of fatty liver, be prepared from by the Chinese crude drug of following weight portion: Poria 8-13 part, Herba Artemisiae 15-20 part, Fructus Crataegi 18-23 part, Herb Gynostemmae Pentaphylli 10-15 part, Flos Sophorae 10-15 part, Folium Camelliae sinensis 4-10 part, Herba Pteridis Multifidae 5-10 part, Rhizoma Polygoni Cuspidati 5-10 part, Paederus densipennis Bernh. 3-9 part, Hirudo 3-9 part.Application publication number CN 104274652 A(application number 201410585263.3) Chinese invention patent document disclose a kind of Chinese medicine for the treatment of fatty liver, the weight proportion of its each raw material components is: Caulis Spatholobi 13-17, Rhizoma Chuanxiong 6-10, Pericarpium Citri Reticulatae 12-15, Radix Jasmini Sambac 6-10, Flos Tagetis Erectae 13-15, Semen livistonae chinensis 4-8, Fructus Ligustri Lucidi 8-10, Herba Hedyotidis Diffusae 2-4, Ramulus Uncariae Cum Uncis 4-6, Flos Camelliae Japonicae 1-3, Fructus Schisandrae Chinensis 6-10, Herba Patriniae 10-14, Herba Leonuri 10-12, deep red pear wood 1-3, Rhizoma Atractylodis Macrocephalae 1-3.

At present, western medicine fatty liver curative effect is obvious, but has side effect and other complication, not easily long-term taking; Chinese medicine is from differential diagnosis of diseases and the dialectical thinking combined, and in clinical research and treatment, adopt the Therapeutic Method that specially side's opinion is controlled to achieve significant curative effect, have significant advantage than Western medicine, prospect is very wide.

Summary of the invention

For the deficiencies in the prior art, the object of this invention is to provide one prepare simply, conveniently take, severe fatty liver patient lipid lowerers safely and effectively.This curative effect of medication is remarkable, without any side effects.

Technical scheme of the present invention is:

Severe fatty liver patient lipid lowerers, is prepared from by following bulk drugs, is weight portion: Semen Sojae Preparatum 10-20; Folium Nelumbinis 15-30; Fructus Crataegi 12-25; Herba Centellae 3-6; Herba Casythae Filiformis 5-9; Herba Taxilli 8-12; Bin youth 9-15; Olibanum 6-9; Radix Aristolochiae 5-10; Caulis Spatholobi 10-15; Hirudo 4-8; Semen Astragali Complanati 9-12; Rhizoma Polygonati Odorati 10-25; Radix Salviae Miltiorrhizae 15-30.

In preferred scheme, Semen Sojae Preparatum 13-17; Folium Nelumbinis 20-25; Fructus Crataegi 17-20; Herba Centellae 4-5; Herba Casythae Filiformis 6-8; Herba Taxilli 9-11; Bin youth 10-14; Olibanum 7-8; Radix Aristolochiae 6-9; Caulis Spatholobi 11-14; Hirudo 5-7; Semen Astragali Complanati 10-11; Rhizoma Polygonati Odorati 15-20; Radix Salviae Miltiorrhizae 20-25.

Be more preferably, Semen Sojae Preparatum 15; Folium Nelumbinis 22.5; Fructus Crataegi 18.5; Herba Centellae 4.5; Herba Casythae Filiformis 7; Herba Taxilli 10; Bin youth 12; Olibanum 7.5; Radix Aristolochiae 7.5; Caulis Spatholobi 12.5; Hirudo 6; Semen Astragali Complanati 10.5; Rhizoma Polygonati Odorati 17.5; Radix Salviae Miltiorrhizae 22.5.

Severe fatty liver patient lipid lowerers, the preparation method of described decoction, step is as follows:

(1) Rhizoma Polygonati Odorati is cleaned, and to put in steamer water proof steaming and decocting 2-4 hour (preferably put in steamer water proof steaming and decocting 3 hours), takes out, shine half-dried, then steam 1-2 hour (preferably steaming 1.5 hours again), slightly vexedly takes out in sepia, cuts sheet, dry, for subsequent use;

(2) Semen Astragali Complanati is cleaned, and add yellow wine and soak 25-35 minute (preferably add yellow wine and soak 30 minutes), be then placed in steamer, water proof steams 40-50 minute (preferred water proof steams 45 minutes), takes out, cools, for subsequent use;

(3) Rhizoma Polygonati Odorati after being processed step (1)-(2) and Semen Astragali Complanati are with surplus stock medicine, add clear water and soak 1.5-2.5 hour (preferably add clear water and soak 2 hours), then intense fire boils 10-20 minute (preferred intense fire boils 15 minutes), turn slow fire boiling twice, first time decocts 30-40 minute (preferably first time decocts 35 minutes), and second time decocts 15-25 minute (preferably second time decocts 20 minutes), merges twice decocting liquid, filter, obtain filtrate 1;

(4) medicinal residues of filtration are added the clear water (preferably the medicinal residues of filtration being added the clear water of 3 times amount) of 2-4 times amount, intense fire boils, and turns slow fire boiling 20 minutes, filters, obtains filtrate 2;

(5) by filtrate 1 and filtrate also 2-in-1, be evaporated to 3/4 of original liquid, dry heat sterilization, cooling, encapsulation, to obtain final product.

The preparation method of above-mentioned severe fatty liver patient blood fat reducing decoction, is characterized in that, in step (3), the amount of clear water is the 6-10 of raw material dose doubly (amount of preferred clear water is 7-9 times of raw material dose, and the amount of the clear water be more preferably is 8 times of raw material dose).

The preparation method of above-mentioned severe fatty liver patient blood fat reducing decoction, is characterized in that, in step (5), the temperature of dry heat sterilization is 80-110 DEG C (temperature of preferred dry heat sterilization is 90-100 DEG C, and the temperature of the dry heat sterilization be more preferably is 95 DEG C).

The preparation method of above-mentioned severe fatty liver patient blood fat reducing decoction, is characterized in that, in step (5), the time of dry heat sterilization is 16-34 minute (time of preferred dry heat sterilization is 20-30 minute, and the time of the dry heat sterilization be more preferably is 25 minutes).

The preparation method of described pill is:

(1) get Olibanum block and add Chinese liquor pouring profit 4 hours, be sucked, dry 2 round the clock with low baking temperature to wine, to oil thoroughly on paper, matter is crisp, and tack-free is degree, and porphyrize is for subsequent use; Sal is made popular in pot, adds Hirudo, continues to stir-fry, and to Hirudo surface in yellowish-brown, takes out, cools, pulverize for subsequent use;

(2) Radix Aristolochiae, Herba Centellae, Herba Taxilli and Rhizoma Polygonati Odorati add soak with ethanol 20-30 minute the soak with ethanol of 75% (preferably add 25 minutes) of 65%-85%, heating and refluxing extraction twice, each respectively extraction 45-65 minute (preferably each each extraction 55 minutes), filter, merge twice alcohol extract, decompression recycling ethanol, is condensed into paste;

(3) by Folium Nelumbinis, Fructus Crataegi, Semen Sojae Preparatum, Semen Arecae, Semen Astragali Complanati, Radix Salviae Miltiorrhizae, Caulis Spatholobi and the soak by water three times adding 8 times of material quantities without leaf rattan, respectively to decoct 30 minutes, collecting decoction, filter, it is the thick paste of 1.20-1.23 that filtrate is concentrated into 60 DEG C of relative densities at every turn;

(4) by step (2) and the mixing of step (3) gained thick paste, be spray dried to dry cream fine powder, mix with step (1) gained raw material medicated powder, with the general ball of alcohol, obtained pill.

The preparation method of described granule is:

(1) Hirudo is dropped in rice-washed water, and sealing is soaked 22-26 hour (preferably sealing immersion 24 hours), takes out, dries, then add Adeps Sus domestica and decoct to sallow, dry, cool, grind, for subsequent use; Semen Astragali Complanati is cleaned, and add yellow wine and soak 25-35 minute (preferably add yellow wine and soak 30 minutes), be then placed in steamer, water proof steams 40-50 minute (preferred water proof steams 45 minutes), takes out, cools, grind for subsequent use; Get Olibanum block and add Chinese liquor pouring profit 4 hours, be sucked, dry 2 round the clock with low baking temperature to wine, to oil thoroughly on paper, matter is crisp, and tack-free is degree, and porphyrize is for subsequent use;

(2) Radix Aristolochiae, Herba Centellae, Herba Taxilli and Rhizoma Polygonati Odorati are cleaned, and in 89 DEG C of dry 1-2 hours (being preferable over 89 DEG C of dryings 1.5 hours), taking out, are placed in Chinese medicine grinder and are ground into fine powder, for subsequent use;

(3) by Folium Nelumbinis, Fructus Crataegi, Semen Sojae Preparatum, Semen Arecae, Radix Salviae Miltiorrhizae, Caulis Spatholobi and the soak by water three times adding 8 times of material quantities without leaf rattan, respectively to decoct 30 minutes, collecting decoction, filter, it is the thick paste of 1.20-1.23 that filtrate is concentrated into 60 DEG C of relative densities at every turn;

(4) step (1)-(2) gained fine medicinal material powder joined in above-mentioned thick paste, stir, add dextrin and sodium cellulosate (thick paste powder: dextrin: sodium cellulosate=6:1.7:1.4), stir and granulate, dry, cross No. four sieves, subpackage, to obtain final product.

The preparation method of described thick paste agent is:

(1) Fructus Crataegi is cleaned, and mixes thoroughly, slightly moistens, put in frying pan with Sucus Zingberis, and moderate heat heats, and fry to the burnt brown of appearance, inner coke yellow, takes out, cool; Olibanum pounds into fritter, separately gets sand and puts in pot, be heated to more than 100 DEG C, then spread paper layer 2-3, upper stand Olibanum block, and when continuing to be heated to fuel-displaced, stirring gently with chopsticks, and change paper 2-3 time, is pearl to Olibanum, and tack-free is degree, takes out, cools;

(2) Rhizoma Polygonati Odorati is cleaned, and to put in steamer water proof steaming and decocting 2-4 hour (preferably put in steamer water proof steaming and decocting 3 hours), takes out, shine half-dried, then steam 1-2 hour (preferably steaming 1.5 hours again), slightly vexedly takes out in sepia, cuts sheet, dry, for subsequent use;

(3) medical material after being processed step (1)-(2) is together placed in crock with surplus stock medical material, and the pure water adding 10 times of medical material amounts soaks 45 minutes, changes slow fire boiling 30 minutes after intense fire boils; Add the pure water of 6 times of medical material amounts for second time, intense fire boils, and turn slow fire boiling 20-30 minute (preferably turning slow fire boiling 25 minutes), merge twice filtrate, being concentrated into 80 DEG C of relative densities is the thick paste of 1.28-1.32, to obtain final product.

Scientific formula of the present invention, preparation method is simple, taking convenience, Be very effective.In addition, excellent results of the present invention also shows:

1,traditional property of medicine and Chinese medicine modern pharmacology organically combine by the present invention, using drugs to form a prescription, directly enter disease institute, promote curative effect;

2,medicine of the present invention has soothing liver and strengthening spleen, and effect of clearing away heat to alleviate pain, reduction blood fat, to severe fatty liver determined curative effect, has no side effect;

3,medicine source is easy to get, and medical material is with low cost, can relieve patient ' s burden.

Detailed description of the invention

Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.

embodiment 1severe fatty liver patient lipid lowerers, is characterized in that, be prepared from by following bulk drugs, is weight portion (65g/ part): Semen Sojae Preparatum 10 parts; 15 parts, Folium Nelumbinis; Fructus Crataegi 12 parts; Herba Centellae 3 parts; Herba Casythae Filiformis 5 parts; Herba Taxilli 8 parts; Bin youth 9 parts; Olibanum 6 parts; Radix Aristolochiae 5 parts; Caulis Spatholobi 10 parts; Hirudo 4 parts; Semen Astragali Complanati 9 parts; Rhizoma Polygonati Odorati 10 parts; Radix Salviae Miltiorrhizae 15 parts.

The preparation method of severe fatty liver patient blood fat reducing decoction is:

(1) Rhizoma Polygonati Odorati is cleaned, and to put in steamer water proof steaming and decocting 2 hours, takes out, shines half-dried, then steam 1 hour, slightly vexedly takes out in sepia, cuts sheet, dry, for subsequent use;

(2) Semen Astragali Complanati is cleaned, and add yellow wine and soak 25 minutes, be then placed in steamer, water proof steams 40 minutes, takes out, cools, for subsequent use;

(3) Rhizoma Polygonati Odorati after being processed step (1)-(2) and Semen Astragali Complanati are with surplus stock medicine, and the clear water adding 6 times of material quantities soaks 1.5 hours, and then intense fire boils 10 minutes, turn slow fire boiling twice, first time decocts 30 minutes, and second time decocts 15 minutes, merge twice decocting liquid, filter, obtain filtrate 1;

(4) medicinal residues of filtration are added the clear water of 2 times amount, intense fire boils, and turns slow fire boiling 20 minutes, filters, obtains filtrate 2;

(5) by filtrate 1 and filtrate also 2-in-1, be evaporated to 3/4 of original liquid, 80 DEG C of dry heat sterilizations 16 minutes, cooling, encapsulation, to obtain final product.

The instructions of taking of decoction of the present invention is: once a day, each 200mL, warmly takes, 15 days courses for the treatment of.

Model case a: XX, man, 46 years old, people from Tai'an.Patient is to our hospital on April 12nd, 2013.Patient's readme: before 2 months without obvious inducement occur inappetence, weak, detest oil, abdominal distention, dull pain in liver, once take analgesic treatment, effect is undesirable, and symptom still continues.My institute of accompanying of layman checks.Check: patient at ordinary times diet is partially greasy, has a good appetite, not eating vegetable, body obesity, do not like motion, B ultrasonic is pointed out: fatty liver severe.

Take the present embodiment gained severe fatty liver patient blood fat reducing decoction, instructions of taking: once a day, each 200mL, warmly to take, 15 days courses for the treatment of.After taking three courses for the treatment of, patients symptomatic takes a turn for the better, and continues two courses for the treatment of of medication, and patient's fatty liver is slight, advises it to do more physical exercises, low fat high protein, high-cellulose diet.Follow up a case by regular visits to after three months, be almost recovered.

embodiment 2severe fatty liver patient lipid lowerers, is characterized in that, be prepared from by following bulk drugs, is weight portion (45g/ part): Semen Sojae Preparatum 20 parts; 30 parts, Folium Nelumbinis; Fructus Crataegi 25 parts; Herba Centellae 6 parts; Herba Casythae Filiformis 9 parts; Herba Taxilli 12 parts; Bin youth 15 parts; Olibanum 9 parts; Radix Aristolochiae 10 parts; Caulis Spatholobi 15 parts; Hirudo 8 parts; Semen Astragali Complanati 12 parts; Rhizoma Polygonati Odorati 25 parts; Radix Salviae Miltiorrhizae 30 parts.

The preparation method of severe fatty liver patient blood fat reducing pill is:

(1) get Olibanum block and add Chinese liquor pouring profit 4 hours, be sucked, dry 2 round the clock with low baking temperature to wine, to oil thoroughly on paper, matter is crisp, and tack-free is degree, and porphyrize is for subsequent use; Sal is made popular in pot, adds Hirudo, continues to stir-fry, and to Hirudo surface in yellowish-brown, takes out, cools, pulverize for subsequent use;

(2) Radix Aristolochiae, Herba Centellae, Herba Taxilli and Rhizoma Polygonati Odorati add the soak with ethanol 25 minutes of 75%, heating and refluxing extraction twice, respectively to extract 55 minutes at every turn, filter, merge twice alcohol extract, decompression recycling ethanol, be condensed into paste;

(3) by Folium Nelumbinis, Fructus Crataegi, Semen Sojae Preparatum, Semen Arecae, Semen Astragali Complanati, Radix Salviae Miltiorrhizae, Caulis Spatholobi and the soak by water three times adding 8 times of material quantities without leaf rattan, respectively to decoct 30 minutes, collecting decoction, filter, it is the thick paste of 1.20-1.23 that filtrate is concentrated into 60 DEG C of relative densities at every turn;

(4) by step (2) and the mixing of step (3) gained thick paste, be spray dried to dry cream fine powder, mix with step (1) gained raw material medicated powder, with the general ball of alcohol, obtained pill.

The instructions of taking of pill of the present invention is: every day three times, each 4-7 ball, and warm water is taken after mixing it with water, 15 days courses for the treatment of.

Model case: Du XX, female, 46 years old, people from Jining.Patient is to our hospital on July 14th, 2013.Patient's readme: occurred persistence Upper abdominal pain without obvious inducement before one week, take food greasy after, pain increases the weight of, and has Nausea and vomiting symptom.Patient has mild fatty hepatitis history, the comparatively light not normal medication treatment of the state of an illness.Diet aspect is not noted very much, does not get enough athletic exercise at ordinary times.Check: patient's upper abdominal muscle is nervous, and middle upper abdomen has obvious tenderness, rebound tenderness, B ultrasonic prompting hepatomegaly, liver cirrhosis, severe fatty liver.

Take the present embodiment gained severe fatty liver patient blood fat reducing pill, instructions of taking: every day three times, each 4-7 ball, warm water is taken after mixing it with water, 15 days courses for the treatment of.Medication after one month patient sb.'s illness took a favorable turn, Nausea and vomiting transference cure, continue to take two courses for the treatment of, patient cures substantially, exhorts that it is careful in one's diet, does more physical exercises, follow up a case by regular visits to and do not recur so far.

embodiment 3severe fatty liver patient lipid lowerers, is characterized in that, be prepared from by following bulk drugs, is weight portion (60g/ part): Semen Sojae Preparatum 13 parts; 20 parts, Folium Nelumbinis; Fructus Crataegi 17 parts; Herba Centellae 4 parts; Herba Casythae Filiformis 6 parts; Herba Taxilli 9 parts; Bin youth 10 parts; Olibanum 7 parts; Radix Aristolochiae 6 parts; Caulis Spatholobi 11 parts; Hirudo 5 parts; Semen Astragali Complanati 10 parts; Rhizoma Polygonati Odorati 15 parts; Radix Salviae Miltiorrhizae 20 parts.

The preparation method of severe fatty liver patient blood-fat-lowering granule agent is:

(1) Hirudo is dropped in rice-washed water, and sealing immersion 24 hours, takes out, dry, then add Adeps Sus domestica and decoct to sallow, dry, cool, and grinds, for subsequent use; Semen Astragali Complanati is cleaned, and add yellow wine and soak 30 minutes, be then placed in steamer, water proof steams 45 minutes, takes out, cools, grind for subsequent use; Get Olibanum block and add Chinese liquor pouring profit 4 hours, be sucked, dry 2 round the clock with low baking temperature to wine, to oil thoroughly on paper, matter is crisp, and tack-free is degree, and porphyrize is for subsequent use;

(2) Radix Aristolochiae, Herba Centellae, Herba Taxilli and Rhizoma Polygonati Odorati are cleaned, and in 89 DEG C of dryings 1.5 hours, take out, are placed in Chinese medicine grinder and are ground into fine powder, for subsequent use;

(3) by Folium Nelumbinis, Fructus Crataegi, Semen Sojae Preparatum, Semen Arecae, Radix Salviae Miltiorrhizae, Caulis Spatholobi and the soak by water three times adding 8 times of material quantities without leaf rattan, respectively to decoct 30 minutes, collecting decoction, filter, it is the thick paste of 1.20-1.23 that filtrate is concentrated into 60 DEG C of relative densities at every turn;

(4) step (1)-(2) gained fine medicinal material powder joined in above-mentioned thick paste, stir, add dextrin and sodium cellulosate (thick paste powder: dextrin: sodium cellulosate=6:1.7:1.4), stir and granulate, dry, cross No. four sieves, subpackage, to obtain final product.

The instructions of taking of granule of the present invention is: every day three times, each 25g, and warm water is taken after mixing it with water, 15 days courses for the treatment of.

Model case: Lee XX, man, 59 years old, people from Tengzhou.Patient is to our hospital in JIUYUE in 2013 2 days.Mr. Li manages a building materials company, because of company's heavy traffic, treats with courtesy more at ordinary times, and frequent and client has a meal and drinks, and diet is irregular, insobriety, and picked-up oils and fats is more.Mr. Li is busy with one's work at ordinary times, does not go to hospital to make regular check on the custom of health, and before one month, Mr. Li feels dizzy, feels run-down in work way, uncomfortable in chest etc., cannot normally work.Under the accompanying of layman, come my institute and check.Check: liver function: transaminase's severe overweight, B ultrasonic is pointed out: severe fatty liver.

Take the agent of the present embodiment gained severe fatty liver patient blood-fat-lowering granule, instructions of taking: every day three times, each 25g, warm water is taken after mixing it with water, 15 days courses for the treatment of.After taking two courses for the treatment of, patient's malaise symptoms is alleviated greatly, and continue to take one month, patient cures substantially, exhorts that Mr. Li keeps on a diet, and adjustment of diet advocates high protein, homovitamin, low sugar, low fat diet.

embodiment 4severe fatty liver patient lipid lowerers, is characterized in that, be prepared from by following bulk drugs, is weight portion (50g/ part): Semen Sojae Preparatum 17 parts; 25 parts, Folium Nelumbinis; Fructus Crataegi 20 parts; Herba Centellae 5 parts; Herba Casythae Filiformis 8 parts; Herba Taxilli 11 parts; Bin youth 14 parts; Olibanum 8 parts; Radix Aristolochiae 9 parts; Caulis Spatholobi 14 parts; Hirudo 7 parts; Semen Astragali Complanati 11 parts; Rhizoma Polygonati Odorati 20 parts; Radix Salviae Miltiorrhizae 25 parts.

The preparation method of severe fatty liver patient blood fat reducing thick paste agent is:

(1) Fructus Crataegi is cleaned, and mixes thoroughly, slightly moistens, put in frying pan with Sucus Zingberis, and moderate heat heats, and fry to the burnt brown of appearance, inner coke yellow, takes out, cool; Olibanum pounds into fritter, separately gets sand and puts in pot, be heated to more than 100 DEG C, then spread paper layer 2-3, upper stand Olibanum block, and when continuing to be heated to fuel-displaced, stirring gently with chopsticks, and change paper 2-3 time, is pearl to Olibanum, and tack-free is degree, takes out, cools;

(2) Rhizoma Polygonati Odorati is cleaned, and to put in steamer water proof steaming and decocting 3 hours, takes out, shines half-dried, then steam 1.5 hours, slightly vexedly takes out in sepia, cuts sheet, dry, for subsequent use;

(3) medical material after being processed step (1)-(2) is together placed in crock with surplus stock medical material, and the pure water adding 10 times of medical material amounts soaks 45 minutes, changes slow fire boiling 30 minutes after intense fire boils; Add the pure water of 6 times of medical material amounts for second time, intense fire boils, and turns slow fire boiling 25 minutes, merges twice filtrate, and being concentrated into 80 DEG C of relative densities is the thick paste of 1.28-1.32, to obtain final product.

The instructions of taking of thick paste agent of the present invention is: twice daily, each 3 spoons, and warm water is taken after mixing it with water, 15 days courses for the treatment of.

Model case: Liu XX, female, 36 years old, people from Tianjin.Patient is to our hospital on October 12nd, 2013.Mrs Liu is the intention people of certain renowned advertising company, because of its job specification, usually needs overtime work, can just comes off duty more than 11 continuous evening two or three months when running into busy, this late custom of sleeping that also made Xiao Li form.In in the dead of night, brain back warp often can be emerged the idea of some excellences, and this allows Xiao Li always enjoy it to the life of putting upside down round the clock.But, not long ago, check out to suffer from severe fatty liver when once having a physical examination.Attempted Chinese medicine and western medicine, effect is not very desirable, comes my institute afterwards check treatment through colleague's introduction.Check: B ultrasonic suggest severe fatty liver, hepatic fibrosis with spleen silght enlargement.

Take the agent of the present embodiment gained severe fatty liver patient blood fat reducing thick paste, instructions of taking: twice daily, each 3 spoons, warm water is taken after mixing it with water, 15 days courses for the treatment of.Medication checked after three courses for the treatment of, and B ultrasonic shows: mild fatty liver, Spleen Sizes of Healthy, and uncomfortable liver area disappears, and advises it to continue to take medicine, alleviating alcohol addiction.Continue two courses for the treatment of of medication, check that liver function is normal, patient fully recovers.

embodiment 5severe fatty liver patient lipid lowerers, is characterized in that, be prepared from by following bulk drugs, is weight portion (55g/ part): Semen Sojae Preparatum 15 parts; 22.5 parts, Folium Nelumbinis; Fructus Crataegi 18.5 parts; Herba Centellae 4.5 parts; Herba Casythae Filiformis 7 parts; Herba Taxilli 10 parts; Bin youth 12 parts; Olibanum 7.5 parts; Radix Aristolochiae 7.5 parts; Caulis Spatholobi 12.5 parts; Hirudo 6 parts; Semen Astragali Complanati 10.5 parts; Rhizoma Polygonati Odorati 17.5 parts; Radix Salviae Miltiorrhizae 22.5 parts.

The preparation method of severe fatty liver patient blood fat reducing decoction is:

(1) Rhizoma Polygonati Odorati is cleaned, and to put in steamer water proof steaming and decocting 3 hours, takes out, shines half-dried, then steam 1.5 hours, slightly vexedly takes out in sepia, cuts sheet, dry, for subsequent use;

(2) Semen Astragali Complanati is cleaned, and add yellow wine and soak 30 minutes, be then placed in steamer, water proof steams 45 minutes, takes out, cools, for subsequent use;

(3) Rhizoma Polygonati Odorati after being processed step (1)-(2) and Semen Astragali Complanati are with surplus stock medicine, and the clear water adding 8 times of raw material doses soaks 2 hours, and then intense fire boils 15 minutes, turn slow fire boiling twice, first time decocts 35 minutes, and second time decocts 20 minutes, merge twice decocting liquid, filter, obtain filtrate 1;

(4) medicinal residues of filtration are added the clear water of 3 times amount, intense fire boils, and turns slow fire boiling 20 minutes, filters, obtains filtrate 2;

(5) by filtrate 1 and filtrate also 2-in-1, be evaporated to 3/4 of original liquid, 95 DEG C of dry heat sterilizations 25 minutes, cooling, encapsulation, to obtain final product.

The instructions of taking of decoction of the present invention is: once a day, each 200mL, warmly takes, 15 days courses for the treatment of.

The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:

Semen Sojae Preparatum: base is former: for the seed of legume soybean processes through steaming net for catching birds or fish.Nature and flavor: bitter, cold.Gui Jing: enter lung, stomach warp.Function cures mainly: induce sweat, relieving restlessness, Xuan Yu, removing toxic substances.Cure the wound cold and heat disease, cold and heat, headache, irritated, uncomfortable in chest.

Folium Nelumbinis: base is former: this product is the dried leaves of nymphaeaceae plant lotus.Chemical analysis: leaf is containing nuciferine, nuciferine, miltanthin, armepavine, pronuciferine (+)-Pronuciferine, N-demethyl nuciferine, D-N-methyl coclaurine, anonaine, liriodendrin, Quercetin, Isoquercitrin, lotus glycoside, tartaric acid, citric acid, malic acid, gluconic acid, oxalic acid, succinic acid, tannin.Also containing the alkaline components of resisting mitosis effect.Nature and flavor: bitter are flat.Gui Jing: return liver, spleen, stomach warp.Effect: clearing away summer-heat, sending up the lucid YANG, cooling blood for hemostasis.Cure mainly: for multiple hemorrhage and puerperal blood faints.

Fructus Crataegi: base is former: be the fruit of rosaceous plant Fructus Crataegi or Crataegi cuneatae.Nature and flavor: acid is sweet, tepor.Gui Jing: enter spleen, stomach, Liver Channel.Function cures mainly: help digestion long-pending, dissipating blood stasis blood, expelling tenia.Control meat to amass, lump in the abdomen, phlegm retention, feeling of fullness, acid regurgitation, dysentery, hemorrhoidal hamorrhage, lumbago, hernia after-pains in puerperal, lochiorrhea, children's's breast food is stagnated.Promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis.For meat stagnation, stomach alkane distension, dysentery stomachache, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, hernia pain, hyperlipidemia.

Herba Centellae: base is former: be herb or the whole herb with root of samphire Herba Centellae.Nature and flavor: toil, cold.Gui Jing: enter liver,spleen,kidney warp.Function cures mainly: clearing away heat-damp and promoting diuresis, subduing swelling and detoxicating.Control eruptive disease stomachache, diarrhea due to summer-heat, dysentery, jaundice due to damp-heat, sand Stranguria, stranguria with blood, tells, is defeated in battle, hemoptysis, conjunctival congestion, and larynx swells, rubella, scabies, furuncle carbuncle poison, traumatic injury.

Herba Casythae Filiformis: base is former: be the herb of canella dodder laurel.Nature and flavor: sweetness and bitterness, cold.Gui Jing: " Quanzhou book on Chinese herbal medicine ": " enter liver, kidney two warp." function cures mainly: clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.Treating the liver heat is become thin, cough due to lung-heat, jaundice, dysentery, epistaxis, stranguria with blood, carbuncle, scabies, scalds.

Herba Taxilli: base is former: be the branch and leaf of Loranthaceae plant Herba Visci, Herba Taxilli or loranthus yadoriki etc.Chemical analysis: Herba Visci stem, leaf are containing oleanolic acid, and β-Amyrin, meso inositol, flavone compound, still isolates Lupeol, cupreol and a flavonoid glycoside.Nature and flavor: bitter sweet are flat.Gui Jing: enter liver, kidney channel.Function cures mainly: invigorating the liver and kidney, bone and muscle strengthening, except rheumatism, and the meridian dredging, beneficial blood, antiabortive.Control soreness of waist and knee joint, muscles and bones flaccidity is weak, hemiplegia, beriberi, anemofrigid-damp arthralgia, vaginal bleeding during pregnancy metrorrhagia, lack of lactation after delivery.

Semen Arecae: base is former: be the seed of babassu Semen Arecae.Chemical analysis: Semen Arecae contains alkaloid 0.3 ~ 0.6%, condensed tannin 15%, fat 14% and areca red.Alkaloid master is arecoline, content 0.1 ~ 0.5%; All the other have arecaidine, demethyl arecaidine, guvacoline, arecolidine, homarecoline etc.It is high that raw areca contains biological alkali number than goods.Nature and flavor: toil, temperature.Gui Jing: enter spleen, stomach, large intestine channel.Function cures mainly: parasite killing, removing mass, the therapeutic method to keep the adverse QI flowing downwards, row water.Control malnutrition due to parasitic infestation, dyspepsia, abdominal distention, heavy after dysentery, malaria, edema, beriberi, accumulation of phlegm in the hypochondrium, crux.

Olibanum: base is former: be the gum resin of olive subject plant Boswellia carterii Birdw.Chemical analysis: resinous 60 ~ 70%, natural gum 27 ~ 35%, volatile oil 3 ~ 8%.The main component of resin is free α, β-boswellic acid 33%, in conjunction with boswellic acid 1.5%, and olibanoresene 33%.Natural gum is calcium salt and the magnesium salt 20% of arabitic acid, bassorin 6%; In addition, still containing amaroid 0.5%.Volatile oil is faint yellow, has fragrance, and containing pinene, racemization-limonene and α, β-phellandrene, its main fragrance ingredient is not bright.Nature and flavor: arduous, temperature.Gui Jing: enter the heart, liver, spleen channel.Function cures mainly: regulating qi and activating blood, and analgesic therapy chases after poison.Control coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge.

Radix Aristolochiae: base is former: be the root of feverfew vladimiria berardioidesLing, vladimiria forrestiiLing and the Dali Radix Aucklandiae.Nature and flavor: " choosing of Yunnan Chinese herbal medicine ": " arduous, temperature." return through lung; Stomach warp.Function cures mainly: 1. " choosing of Yunnan Chinese herbal medicine ": " depressed liver-energy dispersing and QI regulating, benefiting stomach and stopping pain.Control stomachache, chronic gastroenteritis, dyspepsia, bronchitis.”

Caulis Spatholobi: base is former: this product is the dry rattan of leguminous plant spatholobus suberectus.Character: this product is oval, long square circle or irregular sheet of cutting sth. askew, thick 0.3-1cm.Cork taupe brown, the visible greyish white mottle had, cork comes off and locates aobvious rufous.Nature and flavor: bitter, sweet, temperature.Gui Jing: return liver, kidney channel.Effect: enrich blood, invigorates blood circulation, dredging collateral.Cure mainly: for menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia.

Hirudo: base is former: be the entirety of Hirudinidae animal blood-eating hirudo, eurysome golden thread leech, dark brown trematodiasis etc.Nature and flavor: salty hardship are flat, poisonous.Gui Jing: enter liver, urinary bladder channel.Function cures mainly: removing blood stasis, and removing blood stasis stimulates the menstrual flow.Control blood-retention, lump in the abdomen, gather, women's amenorrhea, blood stasis becomes consumptive disease, injury from falling down, and order is pain also, nebula.

Semen Astragali Complanati: base is former: be the seed of leguminous plant astragatus complanatus or Seem Astragali.Nature and flavor: sweet, temperature.Gui Jing: enter liver, kidney channel.Function cures mainly: tonifying liver, kidney tonifying, improving eyesight, controlling nocturnal emission with astringent drugs.Treating the liver kidney deficiency, soreness of waist and knee joint, blurred vision, seminal emission premature ejaculation, frequent micturition, the enuresis, hematuria, leucorrhea.

Rhizoma Polygonati Odorati: base is former: be the rhizome of liliaceous plant Rhizoma Polygonati Odorati.Nature and flavor: sweet are flat.Gui Jing: enter lung, stomach warp.Function cures mainly: yin nourishing, moisturizes, and relieving restlessness is quenched the thirst.Control calentura the moon wound, cough excessive thirst, deficient fever, rapid digestion of food is easily hungry, frequent micturition.

Radix Salviae Miltiorrhizae: base is former: this product is the dry root and rhizome of labiate Radix Salviae Miltiorrhizae.Chemical analysis: containing TANSHINONES, iso tanshinone, cryptotanshinone, different cryptotanshinone, methyltanshinone, hydroxyl TANSHINONES etc.Character: this product rhizome is short and thick, top is residual stem foot sometimes.Radical bar, elongated cylindrical, slightly bending, some branches tool must shape radicula.Nature and flavor: bitter, are slightly cold.Gui Jing: GUIXIN, Liver Channel.Effect: stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.Cure mainly: for menoxenia, amenorrhea dysmenorrhea ， lumps in the chest and abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.

test example 1the clinical practice of gained severe fatty liver patient lipid lowerers (embodiment 5) of the present invention:

1 data and method

1.1 physical data

Choose the patient being diagnosed as severe fatty liver that in October ,-2013 in July, 2010, my institute accepted for medical treatment totally 200 examples, wherein male 128 example, women 72 example, the age 33-60 year, 55 years old mean age.

1.2 screening criteria

(1) the interior total fat amount of liver is more than 25%; (2) liver enlargement, flat, sliding, soft, unsharp border, without obvious tenderness, and determines liver patient without other; (3) the iconography display fatty liver such as ultrasonic, the CT of Type B is with hepatic fibrosis or liver cirrhosis; (4) liver histological diagnosis confirms.(5) traditional Chinese medical science inspection: distending pain over the hypochondrium or dull pain, soreness of the loins and weakness of the limbs, malaise, poor appetite, white and greasy fur, thready and rolling pulse.

1.3 Therapeutic Method

All patients are divided into treatment group and matched group at random, and two groups of patients, in sex, the state of an illness, the course of disease etc., through statistical procedures no significant difference (P > 0.05), have comparability.Wherein treatment group takes gained medicine of the present invention, and matched group takes other medicine (as conventional medication such as En Ganding, DANGFEI LIGANNING JIAONANG, fatty liver treating notoginseng balls).Treat four courses for the treatment of altogether.

1.4 curative effect determinate standard

Clinical cure: sings and symptoms all disappears, normally, ultrasound diagnosis recovers normal for blood fat and liver function test result; Effective: sings and symptoms reduces over half, and blood fat and liver function test symptom obviously alleviate, and ultrasound diagnosis is clearly better; Effective: sings and symptoms partial disappearance or minimizing, blood fat and liver function test result make moderate progress, and B ultrasonic display symptom takes a turn for the better; Invalid: sings and symptoms, without minimizing, checks without improving or taking a turn for the better.

1.5 therapeutic outcome

Result is as shown in table 1.

Table 1: the therapeutic outcome for the treatment of group and matched group patient

Therapeutic effect: cure 63 examples (63%), effective 25 examples (25%), effective 9 examples (9%), invalid 3 examples (3%), total effective rate 97%.Treatment group successful is better than matched group.

Take period symptom and physical change of spirit as shown in table 2.

Table 2: take period two groups of patients symptomatic and physical change of spirit thereof

The present invention is prepared from by 14 taste primary raw material medicines such as Semen Sojae Preparatum, Folium Nelumbinis, Fructus Crataegi, Herba Centellae, Herba Casythae Filiformis, Herba Taxilli, Bin youth, Olibanum, Radix Aristolochiae, Caulis Spatholobi and Hirudos, produce synergism after making these drug regimens, better can reach the object of blood fat reducing.Fang Zhong, Semen Sojae Preparatum has and induces sweat, relieving restlessness, Xuan Yu, the effect of removing toxic substances; Herba Centellae and Herba Casythae Filiformis clearing away heat-damp and promoting diuresis, subduing swelling and detoxicating; Herba Taxilli invigorating the liver and kidney, bone and muscle strengthening, except rheumatism, the meridian dredging; Olibanum regulating qi and activating blood, analgesic therapy, chases after poison; Radix Aristolochiae depressed liver-energy dispersing and QI regulating, benefiting stomach and stopping pain; Caulis Spatholobi is enriched blood, and invigorates blood circulation, dredging collateral; Semen Astragali Complanati treating the liver kidney deficiency, soreness of waist and knee joint Be very effective.Full side's compatibility, altogether long memorial liver spleen, effect of clearing away heat to alleviate pain, reduction blood fat.Treat four courses for the treatment of, treatment group total effective rate is 97%, and matched group total effective rate is only 79%.

It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.

Claims (10)

1. severe fatty liver patient lipid lowerers, is characterized in that, is prepared from by following bulk drugs, is weight portion: Semen Sojae Preparatum 10-20; Folium Nelumbinis 15-30; Fructus Crataegi 12-25; Herba Centellae 3-6; Herba Casythae Filiformis 5-9; Herba Taxilli 8-12; Bin youth 9-15; Olibanum 6-9; Radix Aristolochiae 5-10; Caulis Spatholobi 10-15; Hirudo 4-8; Semen Astragali Complanati 9-12; Rhizoma Polygonati Odorati 10-25; Radix Salviae Miltiorrhizae 15-30.

2. severe fatty liver patient lipid lowerers as claimed in claim 1, is characterized in that, be prepared from by following bulk drugs, be weight portion: Semen Sojae Preparatum 13-17; Folium Nelumbinis 20-25; Fructus Crataegi 17-20; Herba Centellae 4-5; Herba Casythae Filiformis 6-8; Herba Taxilli 9-11; Bin youth 10-14; Olibanum 7-8; Radix Aristolochiae 6-9; Caulis Spatholobi 11-14; Hirudo 5-7; Semen Astragali Complanati 10-11; Rhizoma Polygonati Odorati 15-20; Radix Salviae Miltiorrhizae 20-25.

3. severe fatty liver patient lipid lowerers as claimed in claim 1, is characterized in that, be prepared from by following bulk drugs, be weight portion: Semen Sojae Preparatum 15; Folium Nelumbinis 22.5; Fructus Crataegi 18.5; Herba Centellae 4.5; Herba Casythae Filiformis 7; Herba Taxilli 10; Bin youth 12; Olibanum 7.5; Radix Aristolochiae 7.5; Caulis Spatholobi 12.5; Hirudo 6; Semen Astragali Complanati 10.5; Rhizoma Polygonati Odorati 17.5; Radix Salviae Miltiorrhizae 22.5.

4. the severe fatty liver patient lipid lowerers as described in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable decoction, preparation method is as follows:

(1) Rhizoma Polygonati Odorati is cleaned, and to put in steamer water proof steaming and decocting 2-4 hour (preferably put in steamer water proof steaming and decocting 3 hours), takes out, shine half-dried, then steam 1-2 hour (preferably steaming 1.5 hours again), slightly vexedly takes out in sepia, cuts sheet, dry, for subsequent use;

(2) Semen Astragali Complanati is cleaned, and add yellow wine and soak 25-35 minute (preferably add yellow wine and soak 30 minutes), be then placed in steamer, water proof steams 40-50 minute (preferred water proof steams 45 minutes), takes out, cools, for subsequent use;

(3) Rhizoma Polygonati Odorati after being processed step (1)-(2) and Semen Astragali Complanati are with surplus stock medicine, add clear water and soak 1.5-2.5 hour (preferably add clear water and soak 2 hours), then intense fire boils 10-20 minute (preferred intense fire boils 15 minutes), turn slow fire boiling twice, first time decocts 30-40 minute (preferably first time decocts 35 minutes), and second time decocts 15-25 minute (preferably second time decocts 20 minutes), merges twice decocting liquid, filter, obtain filtrate 1;

(4) medicinal residues of filtration are added the clear water (preferably the medicinal residues of filtration being added the clear water of 3 times amount) of 2-4 times amount, intense fire boils, and turns slow fire boiling 20 minutes, filters, obtains filtrate 2;

(5) by filtrate 1 and filtrate also 2-in-1, be evaporated to 3/4 of original liquid, dry heat sterilization, cooling, encapsulation, to obtain final product.

5. the preparation method of severe fatty liver patient blood fat reducing decoction according to claim 4, it is characterized in that, in step (3), the amount of clear water is the 6-10 of raw material dose doubly (amount of preferred clear water is 7-9 times of raw material dose, and the amount of the clear water be more preferably is 8 times of raw material dose).

6. the preparation method of severe fatty liver patient blood fat reducing decoction according to claim 4, it is characterized in that, in step (5), the temperature of dry heat sterilization is 80-110 DEG C (temperature of preferred dry heat sterilization is 90-100 DEG C, and the temperature of the dry heat sterilization be more preferably is 95 DEG C).

7. the preparation method of severe fatty liver patient blood fat reducing decoction according to claim 4, it is characterized in that, in step (5), the time of dry heat sterilization is 16-34 minute (time of preferred dry heat sterilization is 20-30 minute, and the time of the dry heat sterilization be more preferably is 25 minutes).

8. the severe fatty liver patient lipid lowerers as described in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable pill, preparation method is as follows:

(1) get Olibanum block and add Chinese liquor pouring profit 4 hours, be sucked, dry 2 round the clock with low baking temperature to wine, to oil thoroughly on paper, matter is crisp, and tack-free is degree, and porphyrize is for subsequent use; Sal is made popular in pot, adds Hirudo, continues to stir-fry, and to Hirudo surface in yellowish-brown, takes out, cools, pulverize for subsequent use;

(2) Radix Aristolochiae, Herba Centellae, Herba Taxilli and Rhizoma Polygonati Odorati add soak with ethanol 20-30 minute the soak with ethanol of 75% (preferably add 25 minutes) of 65%-85%, heating and refluxing extraction twice, each respectively extraction 45-65 minute (preferably each each extraction 55 minutes), filter, merge twice alcohol extract, decompression recycling ethanol, is condensed into paste;

(3) by Folium Nelumbinis, Fructus Crataegi, Semen Sojae Preparatum, Semen Arecae, Semen Astragali Complanati, Radix Salviae Miltiorrhizae, Caulis Spatholobi and the soak by water three times adding 8 times of material quantities without leaf rattan, respectively to decoct 30 minutes, collecting decoction, filter, it is the thick paste of 1.20-1.23 that filtrate is concentrated into 60 DEG C of relative densities at every turn;

(4) by step (2) and the mixing of step (3) gained thick paste, be spray dried to dry cream fine powder, mix with step (1) gained raw material medicated powder, with the general ball of alcohol, obtained pill.

9. the severe fatty liver patient lipid lowerers as described in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable granule, preparation method is as follows:

(1) Hirudo is dropped in rice-washed water, and sealing is soaked 22-26 hour (preferably sealing immersion 24 hours), takes out, dries, then add Adeps Sus domestica and decoct to sallow, dry, cool, grind, for subsequent use; Semen Astragali Complanati is cleaned, and add yellow wine and soak 25-35 minute (preferably add yellow wine and soak 30 minutes), be then placed in steamer, water proof steams 40-50 minute (preferred water proof steams 45 minutes), takes out, cools, grind for subsequent use; Get Olibanum block and add Chinese liquor pouring profit 4 hours, be sucked, dry 2 round the clock with low baking temperature to wine, to oil thoroughly on paper, matter is crisp, and tack-free is degree, and porphyrize is for subsequent use;

(2) Radix Aristolochiae, Herba Centellae, Herba Taxilli and Rhizoma Polygonati Odorati are cleaned, and in 89 DEG C of dry 1-2 hours (being preferable over 89 DEG C of dryings 1.5 hours), taking out, are placed in Chinese medicine grinder and are ground into fine powder, for subsequent use;

(3) by Folium Nelumbinis, Fructus Crataegi, Semen Sojae Preparatum, Semen Arecae, Radix Salviae Miltiorrhizae, Caulis Spatholobi and the soak by water three times adding 8 times of material quantities without leaf rattan, respectively to decoct 30 minutes, collecting decoction, filter, it is the thick paste of 1.20-1.23 that filtrate is concentrated into 60 DEG C of relative densities at every turn;

(4) step (1)-(2) gained fine medicinal material powder joined in above-mentioned thick paste, stir, add dextrin and sodium cellulosate (thick paste powder: dextrin: sodium cellulosate=6:1.7:1.4), stir and granulate, dry, cross No. four sieves, subpackage, to obtain final product.

10. the severe fatty liver patient lipid lowerers as described in claim 1-3, is characterized in that, be made into pharmaceutically acceptable thick paste agent, preparation method is as follows:

(1) Fructus Crataegi is cleaned, and mixes thoroughly, slightly moistens, put in frying pan with Sucus Zingberis, and moderate heat heats, and fry to the burnt brown of appearance, inner coke yellow, takes out, cool; Olibanum pounds into fritter, separately gets sand and puts in pot, be heated to more than 100 DEG C, then spread paper layer 2-3, upper stand Olibanum block, and when continuing to be heated to fuel-displaced, stirring gently with chopsticks, and change paper 2-3 time, is pearl to Olibanum, and tack-free is degree, takes out, cools;

(2) Rhizoma Polygonati Odorati is cleaned, and to put in steamer water proof steaming and decocting 2-4 hour (preferably put in steamer water proof steaming and decocting 3 hours), takes out, shine half-dried, then steam 1-2 hour (preferably steaming 1.5 hours again), slightly vexedly takes out in sepia, cuts sheet, dry, for subsequent use;

(3) medical material after being processed step (1)-(2) is together placed in crock with surplus stock medical material, and the pure water adding 10 times of medical material amounts soaks 45 minutes, changes slow fire boiling 30 minutes after intense fire boils; Add the pure water of 6 times of medical material amounts for second time, intense fire boils, and turn slow fire boiling 20-30 minute (preferably turning slow fire boiling 25 minutes), merge twice filtrate, being concentrated into 80 DEG C of relative densities is the thick paste of 1.28-1.32, to obtain final product.