CN104606441A - Traditional Chinese medicine composition for treating postmenopausal osteoporosis caused by deficiency of the kidney-yang - Google Patents
Traditional Chinese medicine composition for treating postmenopausal osteoporosis caused by deficiency of the kidney-yang Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating postmenopausal osteoporosis caused by deficiency of the kidney-yang. The composition is prepared by taking fructus psoraleae, morinda officinalis, cortex acanthopanacis, gorgon fruits, Chinese yams, semen cuscutae, caulis spatholobi, pericarpium citri reticulatae and prepared rehmannia roots as medicinal raw materials. The medicines are combined in use and together play roles of warming and invigorating kidney yang, replenishing and filling essence, nourishing the blood and promoting blood circulation, strengthening tendons and bones and supplementing yin and yang, internal causes are fully transferred, the medicines act on multiple links of osteoporosis disease, and the traditional Chinese medicine composition is small in adverse reaction and side effect, high in cure rate and high in effective rate, treats both symptoms and root causes and is an effective prescription.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of Chinese medicine composition for the treatment of kidney-yang deficiency type postmenopausal osteoporosis.
Background technology
Postmenopausal osteoporosis (postmenopausal osteoporosis PMOP) refers to that postmenopausal women is due to ovarian failure, decrease in estrogen, bone resorption is greater than bone formation, what occur moves back shape property with the microstructure of Low BMD and osseous tissue and becomes feature, and clinical manifestation is a kind of metabolic disease that bone fragility and fracture susceptibility increase.Osteoporosis is a kind of commonly encountered diseases of postmenopausal women, and it is bone metabolism dysfunctional disease the most common at present.
Modern medicine is thought, osteoporosis is one of the skeletal system, metabolic osteopathy that many reasons causes, its cause of disease and pathogenesis complexity, be summarised as the exception of hormone regulating and controlling, trophic factor, physical factor, inherited genetic factors, and affect relevant with some drugs.Have the Western medicine medicine of osteoporosis treatment: 1) Bone formation medicine: androgen, protein stimulatory synthetic hormone etc.; 2) anti-bone resorption medicine: estrogen, estrogen antagonist agent, calcitonin, diphosphonate; 3) suppression bone resorption and promoting bone growing medicine is had concurrently: plant estrogen medicine, vitamin D and derivant thereof; 4) other: parathyroid hormone, phenothiazine drug.But said medicine all has obvious toxic action because of life-time service, easily cause complication or because of uncertain therapeutic efficacy fixed, dosage is difficult to grasp or is difficult to popularize because of price, the ideal medicament of non-osteoporosis treatment.
Postmenopausal osteoporosis is modern medicine noun, judges, surely belong to the categories such as traditional Chinese medical science bone withers, rheumatism involving the bone, lumbago according to its clinical classical symptom, pathogenesis main with deficiency of both the liver and kidney, the weak blood deficiency of spleen, obstruction of collaterals by blood stasis of working hard is relevant." Plain Questions ancient times innocence opinion a section " is said " woman seven years old, kidney qi is contained, and dental transition is sent out long ... seventy-seven, conception vessel is empty, and taichong channel declines few, exhaustion of kidney-essence with promoting reproductive function, menopause, therefore senile appearance and loss of fecundity are also.The kidney dominating water metabolism, hides the essence at six mansions and hide it, therefore five hides Sheng, are to rush down by five.All decline in modern five Tibetan, debility of the bone and muscle, using up kidney-essence with promoting reproductive function ", it has set forth women's growth promoter and old and feeble distinctive physiological process, and kidney qi foot is also described, then skeleton is powerful.Kidney governing bones, waist is house of kidney, is the root of yang-energy.Woman's exhaustion of kidney-essence with promoting reproductive function, deficiency of kidney-essence, virtuous sun temperature, can not replenishing vital QI with drugs of warm nature muscles and bones according to impaired, and cause chills and pain of the waist and kness, its etiology and pathogenesis is kidney yang deficiency.
Really there is certain advantage in Chinese medicine postmenopausal osteoporosis, side effect is little, and safety is high, with strong points, is good at improving clinical symptoms, improves the quality of life of patient, have wide investigation and application prospect.But Chinese medicine primary disease still exists many deficiencies, such as the clinical prescriptions of Chinese medicine about postmenopausal osteoporosis is uneven at present, and tonic uses and spreads unchecked, and TCM Syndrome Type is of a great variety.Although the clinical efficacy bestowing corresponding treatment for indivedual pattern of syndrome is considerable, use the TCM syndrome of traditional Chinese medical science organic conception summary and induction primary disease, then the clinical research of " suiting the remedy to the case " according to determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs thought is little.
Summary of the invention
The object of the invention is to the advanced method in conjunction with modern medicine, use the TCM syndrome of traditional Chinese medical science organic conception summary and induction primary disease, " suit the remedy to the case " according to determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs thought again, a kind of Chinese medicine composition for the treatment of kidney-yang deficiency type postmenopausal osteoporosis is provided, make it have side effect little, safety is high, with strong points, improve clinical symptoms simultaneously, improve the quality of life of patient.
To achieve these goals, the present invention adopts following scheme:
A kind of Chinese medicine composition for the treatment of kidney-yang deficiency type postmenopausal osteoporosis, it is that medicinal raw material is made by Fructus Psoraleae, Radix Morindae Officinalis, Cortex Acanthopancis, Semen Euryales, Rhizoma Dioscoreae, Semen Cuscutae, Caulis Spatholobi, Pericarpium Citri Reticulatae, Radix Rehmanniae Preparata, and the weight proportion of each medicinal raw material is as follows: Fructus Psoraleae 11-16 part, Radix Morindae Officinalis 18-23 part, Cortex Acanthopancis 13-18 part, Semen Euryales 11-16 part, Rhizoma Dioscoreae 25-30 part, Semen Cuscutae 9-15 part, Caulis Spatholobi 8-13 part, Pericarpium Citri Reticulatae 5-9 part, Radix Rehmanniae Preparata 15-20 part.
Radix Morindae Officinalis kidney-replenishing, bone and muscle strengthening in side, Fructus Psoraleae the kidney warming is with supporing yang, and Cortex Acanthopancis invigorating the liver and kidney, bone and muscle strengthening three medicine 5 are with not only kidney-replenishing, bone and muscle strengthening but also Liver and kidney, with mending warming the spleen of holding concurrently, were monarch drug; Radix Rehmanniae Preparata nourishing YIN and supplementing blood, beneficial essence fills out marrow, the flat invigorating the liver and kidney of Semen Cuscutae, is ministerial drug, and this is namely so-called, and " kind YANG invigorating person, must in treating YANG within YIN, then positive cloudy helping and biochemical infinite." Rhizoma Dioscoreae spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission; Pericarpium Citri Reticulatae regulating qi-flowing for strengthening spleen, Semen Euryales supplementing the kidney to control the nocturnal, spleen reinforcing antidiarrheal; The kidney invigorating does not forget spleen reinforcing, and negative and positive are transformed; Caulis Spatholobi is enriched blood, and invigorates blood circulation, dredging collateral, essence and blood sharing the same origin, has both trained and has mended day after tomorrow the source of vital function to fill kidney essense, reaches again that invigorating middle warmer residence is logical, the object of tonify without causing stagnation.All medicines share, and become warming and recuperating the kidney-YANG, benefiting essence and marrow, nourshing blood and promoting blood circulation, strengthening the tendons and bones altogether, tonifying both YIN and YANG, give full play to endogenous cause of ill, act on multiple links of developing osteoporosis, treating both the principal and secondary aspects of a disease, are a first effectively good recipe.
Preferably, treat a Chinese medicine composition for kidney-yang deficiency type postmenopausal osteoporosis, it is characterized in that it is made up of the medicinal raw material of weight proportion as described below: Fructus Psoraleae 13-16 part, Radix Morindae Officinalis 18-23 part, Cortex Acanthopancis 14-17 part, Semen Euryales 12-14 part, Rhizoma Dioscoreae 25-30 part, Semen Cuscutae 13-15 part, Caulis Spatholobi 11-13 part, Pericarpium Citri Reticulatae 6-8 part, Radix Rehmanniae Preparata 16-18 part.
Further preferably, treat a Chinese medicine composition for kidney-yang deficiency type postmenopausal osteoporosis, it is characterized in that it is made up of the medicinal raw material of weight proportion as described below: Fructus Psoraleae 15 parts, Radix Morindae Officinalis 21 parts, Cortex Acanthopancis 15 parts, Semen Euryales 13 parts, Rhizoma Dioscoreae 27 parts, Semen Cuscutae 14 parts, Caulis Spatholobi 12 parts, Pericarpium Citri Reticulatae 7 parts, Radix Rehmanniae Preparata 17 parts.
In side, the pharmacological activity of each medicinal raw material used is summarized as follows.
Fructus Psoraleae: pungent, bitter, temperature.Return kidney, spleen channel.Function cures mainly: warming the kidney to activate YANG, improving inspiration by invigorating kidney-QI, antidiarrheal.For impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, Diarrhoea; External curing vitiligo, alopecia areata.
Radix Morindae Officinalis: sweet, pungent, tepor.Return kidney, Liver Channel.Function cures mainly: kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.For impotence and seminal emission, cold womb is infertile, menoxenia, and few abdomen cold type of pain, rheumatic arthralgia, muscles and bones flaccidity is soft.
Cortex Acanthopancis: pungent, bitter, temperature.Return liver, kidney channel.Function cures mainly: wind-damp dispelling, invigorating the liver and kidney, bone and muscle strengthening.For rheumatic arthralgia, muscles and bones flaccidity is soft, children's's walking retardation in children, and body void is weak, edema, beriberi.
Semen Euryales: sweet, puckery is flat.Return spleen, kidney channel.Function cures mainly: supplementing the kidney to control the nocturnal, spleen reinforcing antidiarrheal, damp eliminating leukorrhagia stopping.For emission, enuresis frequent micturition, insufficiency of the spleen chronic diarrhea, nebulousurine, leukorrhagia.
Rhizoma Dioscoreae: sweet, flat.Return spleen, lung, kidney channel.Function cures mainly: spleen reinforcing nourishing the stomach, and promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission.For insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, and deficiency-heat is quenched one's thirst.Rhizoma Dioscoreae (parched with bran) spleen reinforcing stomach invigorating.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, leukorrhagia.Rhizoma Dioscoreae (parched with bran): get pure Yam slice, fries to yellow according to parched with bran method (Chinese Pharmacopoeia 2010 editions appendix II D).
Semen Cuscutae: sweet, temperature.Return liver,kidney,spleen warp.Function cures mainly: nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.For impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen is suffered from a deficiency of the kidney and is rushed down; Externally treating leucoderma.
Caulis Spatholobi: bitter, sweet, temperature.Return liver, kidney channel.Function cures mainly: enrich blood, and invigorates blood circulation, dredging collateral.For menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia.
Pericarpium Citri Reticulatae: bitter, pungent, temperature.Return lung, spleen channel.Function cures mainly: regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.
Radix Rehmanniae Preparata: sweet, tepor.Return liver, kidney channel.Function cures mainly: nourishing YIN and supplementing blood, and beneficial essence fills out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, and metrostaxis is dizzy, tinnitus, early whitening of beard and hair.
The mode that Chinese medicine composition of the present invention can be taken orally is applied to the patient needing this treatment.For time oral, one or more pharmaceutically acceptable carriers can be added, be made into conventional oral formulations, as tablet, capsule, soft capsule, dispersible tablet, oral liquid, granule, chewable tablet, pill, drop pill, slow releasing tablet, slow releasing capsule, controlled release tablet, controlled release capsule, suspensoid, syrup.
Described carrier comprises the excipient, filler, binding agent, wetting agent, disintegrating agent, absorption enhancer, surfactant, absorption carrier, lubricant etc. of pharmaceutical field routine, such as: selectable filler has: starch, Icing Sugar, calcium phosphate, calcium sulfate two water thing, dextrin, microcrystalline Cellulose, lactose, pregelatinized Starch, mannitol etc.; Selectable binding agent has: sodium carboxymethyl cellulose, PVP-K30, hydroxypropyl cellulose, starch slurry, methylcellulose, ethyl cellulose, hypromellose, gelling starch etc.; Selectable disintegrating agent has: dried starch, polyvinylpolypyrrolidone, cross-linking sodium carboxymethyl cellulose, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose etc.; Selectable lubricant has; Magnesium stearate, Pulvis Talci, sodium lauryl sulphate, micropowder silica gel etc.
Drug composition oral preparation of the present invention is preferably tablet, capsule or granule.
The preparation method of Chinese medicine composition of the present invention comprises following steps:
1), get the Fructus Psoraleae of recipe quantity, Radix Morindae Officinalis, Cortex Acanthopancis add ethanol extraction secondary, each 1-2 hour, merge extractive liquid, filter, filtrate recycling ethanol, being evaporated to relative density is 1.03-1.10 (recording in 60 DEG C);
2) Semen Euryales of recipe quantity, Rhizoma Dioscoreae, Semen Cuscutae, Caulis Spatholobi, Pericarpium Citri Reticulatae, Radix Rehmanniae Preparata, is got, decoct with water twice, first time 5-8 times of the amount of water material total amount of getting it filled that is this step, decoct 2-3 hour, the 3-4 of the second time amount of water material total amount of getting it filled that is this step doubly decocts 1-2 hour, collecting decoction, filter, filtrate reduced in volume, adds ethanol and makes alcohol content be 45-60%, place 12 hours, filter, filtrate recycling ethanol, being concentrated into relative density is 1.01-1.10 (recording in 60 DEG C)
3), merge above two kinds of thick pastes, add one or more pharmaceutically acceptable carriers, adopt the conventional method manufacture in field of traditional Chinese medicine pharmacy to obtain conventional Chinese medicine pharmaceutical dosage form clinically.As tablet, capsule, soft capsule, dispersible tablet, oral liquid, granule, chewable tablet, oral cavity disintegration tablet, drop pill, slow releasing tablet, slow releasing capsule, controlled release tablet, controlled release capsule, suspending agent, syrup etc.
Inventor is according to self clinical experience for many years, use the TCM syndrome of traditional Chinese medical science organic conception summary and induction primary disease, " suit the remedy to the case " according to determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs thought again, adopt traditional Chinese medicine composition for treating kidney-yang deficiency type postmenopausal osteoporosis Be very effective of the present invention, be now summarized as follows.
1, physical data: 85 routine patients are observed in this research altogether, be my institute's department of endocrinology outpatient service in October ,-2013 in April, 2013, Orthopaedics Clinic and inpatient, 51 ~ 65 years old age, 58.3 ± 5.4 years old mean age, average menopause 5.7 ± 2.7, treatment group 45 example is divided into, matched group 40 example according to random digits table.Two groups of patient's physical data no significant difference (P > 0.05), have comparability.
2, diagnostic criteria:
Western medicine diagnose: dual energy X-ray absorptiometry measuring instrument measures bone density, the bone amount of recommending with WHO for diagnostic criteria, carries out comprehensive descision in conjunction with age of patient, medical history, fracture and lab testing etc. lower than two standard deviations of same sex population's peak bone mass simultaneously.
Differential diagnosis in tcm: with reference to " new Chinese medicine guideline of clinical investigations " (Zheng Xiao cornel, Chinese science and technology publishing house: 2002) and " National Standard of the People's Republic of China's tcm clinical practice diagnosis and treatment term syndrome part " of Issued by China State Bureau of Technical Supervision intend with primary symptom: 1. soreness of the waist and knees or pain; 2. coldness of the body with chills is very with lower limb especially.Secondary disease: 1. head's discrimination is swooned, spiritlessness and weakness; 2. complexion is white or dark all of a sudden; 3. clear urine in large amounts, nocturia; 4. defecate chronic diarrhea or diarrhea before dawn muddy; 5. clear and thin leucorrhea amount is many.Tongue arteries and veins: light red tongue is fat, beats with a stick white, deep-thready pulse string.In primary symptom+secondary disease, any 2+typical tongue arteries and veins can be diagnosed as this pattern of syndrome.
3, exclusion standard: do not meet diagnosis of osteoporosis standard; The disease of the interference such as metabolic osteopathy, Chronic Liver, kidney diaseases and autoimmune pathologies bone metabolism; Secondary osteoporosis patient, as: suffer from the incretion diseases such as severe diabetes mellitus, hyperthyroidism, hyperparathyroidism; Once ovary was extractd; Suffer from rheumatoid arthritis; Suffer from bone tumor; Once osteosporosis resistant medicament or the other influences bone metabolism medicine persons such as estrogen, calcium preparation, diphosphate, vitamin D was used in half a year; Took the medicine that glucocorticoid, nonsteroidal antiinflammatory drug, immunomodulator etc. affect cytokine generation; Suffer from other Low BMD metabolic diseases and other serious Cardial or cerebral vascular diseases patients; Merge uterine milk gland disease person.
4, Therapeutic Method: capsule (every 0.4g, containing crude drug 1.44g) prepared by the oral embodiment of the present invention 1 for the treatment of group, day 2 times, each 3-4 grain; The oral solid nation (Shijiazhuang Ouyi Pharmaceutical Co., Ltd, 10mg/ sheet, the accurate word H10980109 of traditional Chinese medicines) of matched group, every day 1 time, each 10mg, rises and take with about 200ml boiled water on an empty stomach morning, and after taking medicine, at least 30min is kept upright position and fasted conditions; Observe all oral Gaierqi D (vitamin D3 and calcium carbonate) of case (Hui Shi-hundred palace pharmaceutical Co. Ltd, every sheet 600mg, the accurate word H10950029 of traditional Chinese medicines), day 1 time, each a slice for two groups.Whole observation case is taken medicine March continuously, and treatments period must not use the various medicines of calcitonin, estrogen, androgen and anabolic hormone, tranquilizer and analgesic agent etc. and other influences pain relief and bone metabolism; Two groups of patients, at treatments period, regularly carry out Effect of follow-up visit by telephone or further consultation, to judge curative effect.
5, observation index: bone density (adopt dual energy X-ray absorptiometry measuring instrument, coefficient of variation <0.1%, measure patient 2nd ~ 4 lateral lumber spine bone density); The related bone metabolism indexes such as estradiol, Bone Gla protein, osteoprotegerin measure; Safety indexes: comprise compliance, adverse events incidence rate and the Liver and kidney function of taking medicine; Drug adverse events content: gastrointestinal tract, nervous system, anaphylaxis etc.
6, statistical method: carry out date processing with SPSS15.0 statistical software.Application X is compared between enumeration data group
2inspection, measurement data application t checks, and P < 0.05 has statistical significance for difference.
7, criterion of therapeutical effect:
Criterion of therapeutical effect according to " new Chinese medicine guideline of clinical investigations " is formulated, and judges symptom and sign curative effect according to integration method.Clinical cure: tcm clinical practice symptom, sign disappear or substantially disappear, sign integration reduces >=90%; Effective: tcm clinical practice symptom and sign obviously improves, sign integration reduces >=70%, < 90%; Effective: tcm clinical practice symptom and sign all take a favorable turn, sign integration reduces >=30%, < 70%; Invalid: to increase the weight of even tcm clinical practice symptom and sign is all not improved, sign integration reduces < 30%.
Note: computing formula (nimodipine method) is: [before (before treatment the rear integration of integration-treatment)/treatment integration] X100%
Syndrome Scale quantitative criteria: primary symptom standards of grading are: without-0 point; Gently-2 points; In-4 points; Heavy-6 points.Secondary disease standards of grading are: without-0 point; Gently-1 point; In-2 points; Heavy-3 points.
8, result
8.1, two groups of TCM syndrome sign comparitive study: after two groups of treatments, curative effect of disease compares, treatment group 45 example, recovery from illness 23 example, effective 12 examples, effective 9 examples, invalid 1 example, total effective rate 97.8%.Matched group 40 example, recovery from illness 7 example, effective 10 examples, effective 13 examples, invalid 10 examples, total effective rate 75.0%.Treatment group total effective rate is better than matched group, and difference has statistical significance (P < 0.05).In table 1.
Table 1 liang group TCM syndrome sign comparitive study (n, %)
8.2, before and after two groups of treatments, lumbar spine bmd change is compared: after treating 3 courses for the treatment of, the BMD of two groups of patients comparatively treats front raising, difference has statistical significance (P<0.05), compare between two groups, treatment group compared with matched group improve more obvious, difference also has statistical significance (P<0.05), illustrates that Chinese medicine preparation of the present invention can improve bone density, promote that bone trabecula is rebuild, promoting bone growing.In table 2.
A table 2 liang group treatment front and back lumbar spine bmd change is compared (
)
Note: compare * P < 0.05 with before treatment; Compare with matched group
#p < 0.05.
8.3, skeleton metabolism difference comparsion before and after two groups of treatments: after treating 3 courses for the treatment of, the estradiol of two groups of patients and osteocalcin level comparatively treat front raising, difference has statistical significance (P<0.05), compare between two groups, treatment group compared with matched group improve more obvious, difference also has statistical significance (P<0.05); The osteoprotegerin level of two groups of patients comparatively treats front reduction; difference has statistical significance (P<0.05); compare between two groups; the amplitude that treatment group reduces compared with matched group is slighter; difference also has statistical significance (P<0.05), illustrates that Chinese medicine composition of the present invention contains the material of class gonadotropic Effect, can increase bone amount; promoting bone growing, suppresses bone resorption.In table 3.
Table 3 liang group treatment front and back skeleton metabolism difference comparsion (
)
Note: compare * P < 0.05 with before treatment; Compare with matched group
#p < 0.05.
In a word, compared with prior art (alendronic Acid), the present invention has following beneficial effect: Chinese medicine preparation of the present invention is made up of natural pure Chinese medicine, untoward reaction and side effect little, cure rate and effective percentage high; Containing multi-medicament component in Chinese medicine preparation of the present invention, action target spot is numerous, while improving symptom, improves bone density, increases bone mineral content, improves bone biomechanical state, treating both the principal and secondary aspects of a disease, Be very effective.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
Embodiment 1
Prescription: Fructus Psoraleae 15 parts, Radix Morindae Officinalis 21 parts, Cortex Acanthopancis 15 parts, Semen Euryales 13 parts, Rhizoma Dioscoreae 27 parts, Semen Cuscutae 14 parts, Caulis Spatholobi 12 parts, Pericarpium Citri Reticulatae 7 parts, Radix Rehmanniae Preparata 17 parts.
Preparation method: get the Fructus Psoraleae of recipe quantity, Radix Morindae Officinalis, Cortex Acanthopancis add ethanol extraction secondary, each 1.5 hours, merge extractive liquid, filter, filtrate recycling ethanol, being evaporated to relative density is 1.05 (recording in 60 DEG C), get the Semen Euryales of recipe quantity, Rhizoma Dioscoreae, Semen Cuscutae, Caulis Spatholobi, Pericarpium Citri Reticulatae, Radix Rehmanniae Preparata, decoct with water twice, first time 6 times of the amount of water material total amount of getting it filled that is this step, decoct 2.5 hours, 3 times of the second time amount of water material total amount of getting it filled that is this step, decoct 1.5 hours, collecting decoction, filter, filtrate reduced in volume, adding ethanol makes alcohol content be 50%, place 12 hours, filter, filtrate recycling ethanol, being concentrated into relative density is 1.05 (recording in 60 DEG C), merge above two kinds of thick pastes, add one or more pharmaceutically acceptable carriers, the conventional method manufacture in field of traditional Chinese medicine pharmacy is adopted to obtain capsule.
Embodiment 2
Prescription: Fructus Psoraleae 13 parts, Radix Morindae Officinalis 18 parts, Cortex Acanthopancis 14 parts, Semen Euryales 12 parts, Rhizoma Dioscoreae 25 parts, Semen Cuscutae 13 parts, Caulis Spatholobi 11 parts, Pericarpium Citri Reticulatae 6 parts, Radix Rehmanniae Preparata 16 parts.
Preparation method: get the Fructus Psoraleae of recipe quantity, Radix Morindae Officinalis, Cortex Acanthopancis add ethanol extraction secondary, each 2 hours, merge extractive liquid, filter, filtrate recycling ethanol, being evaporated to relative density is 1.03 (recording in 60 DEG C), get the Semen Euryales of recipe quantity, Rhizoma Dioscoreae, Semen Cuscutae, Caulis Spatholobi, Pericarpium Citri Reticulatae, Radix Rehmanniae Preparata, decoct with water twice, first time 5 times of the amount of water material total amount of getting it filled that is this step, decoct 2 hours, 4 times of the second time amount of water material total amount of getting it filled that is this step, decoct 2 hours, collecting decoction, filter, filtrate reduced in volume, adding ethanol makes alcohol content be 45%, place 12 hours, filter, filtrate recycling ethanol, being concentrated into relative density is 1.08 (recording in 60 DEG C), merge above two kinds of thick pastes, add one or more pharmaceutically acceptable carriers, the conventional method manufacture in field of traditional Chinese medicine pharmacy is adopted to obtain capsule.
Embodiment 3
Prescription: Fructus Psoraleae 16 parts, Radix Morindae Officinalis 23 parts, Cortex Acanthopancis 17 parts, Semen Euryales 14 parts, Rhizoma Dioscoreae 30 parts, Semen Cuscutae 15 parts, Caulis Spatholobi 13 parts, Pericarpium Citri Reticulatae 8 parts, Radix Rehmanniae Preparata 18 parts.
Preparation method: get the Fructus Psoraleae of recipe quantity, Radix Morindae Officinalis, Cortex Acanthopancis add ethanol extraction secondary, each 1.5 hours, merge extractive liquid, filter, filtrate recycling ethanol, being evaporated to relative density is 1.10 (recording in 60 DEG C), get the Semen Euryales of recipe quantity, Rhizoma Dioscoreae, Semen Cuscutae, Caulis Spatholobi, Pericarpium Citri Reticulatae, Radix Rehmanniae Preparata, decoct with water twice, first time 7 times of the amount of water material total amount of getting it filled that is this step, decoct 3 hours, 3 times of the second time amount of water material total amount of getting it filled that is this step, decoct 1 hour, collecting decoction, filter, filtrate reduced in volume, adding ethanol makes alcohol content be 60%, place 12 hours, filter, filtrate recycling ethanol, being concentrated into relative density is 1.10 (recording in 60 DEG C), merge above two kinds of thick pastes, add one or more pharmaceutically acceptable carriers, the conventional method manufacture in field of traditional Chinese medicine pharmacy is adopted to obtain tablet.
Embodiment 4
Prescription: Fructus Psoraleae 14 parts, Radix Morindae Officinalis 22 parts, Cortex Acanthopancis 16 parts, Semen Euryales 12 parts, Rhizoma Dioscoreae 30 parts, Semen Cuscutae 15 parts, Caulis Spatholobi 11 parts, Pericarpium Citri Reticulatae 6 parts, Radix Rehmanniae Preparata 16 parts.
Preparation method: get the Fructus Psoraleae of recipe quantity, Radix Morindae Officinalis, Cortex Acanthopancis add ethanol extraction secondary, each 2 hours, merge extractive liquid, filter, filtrate recycling ethanol, being evaporated to relative density is 1.07 (recording in 60 DEG C), get the Semen Euryales of recipe quantity, Rhizoma Dioscoreae, Semen Cuscutae, Caulis Spatholobi, Pericarpium Citri Reticulatae, Radix Rehmanniae Preparata, decoct with water twice, first time 5 times of the amount of water material total amount of getting it filled that is this step, decoct 2 hours, 4 times of the second time amount of water material total amount of getting it filled that is this step, decoct 2 hours, collecting decoction, filter, filtrate reduced in volume, adding ethanol makes alcohol content be 55%, place 12 hours, filter, filtrate recycling ethanol, being concentrated into relative density is 1.07 (recording in 60 DEG C), merge above two kinds of thick pastes, add one or more pharmaceutically acceptable carriers, the conventional method manufacture in field of traditional Chinese medicine pharmacy is adopted to obtain tablet.
Embodiment 5
Prescription: Fructus Psoraleae 13 parts, Radix Morindae Officinalis 23 parts, Cortex Acanthopancis 16 parts, Semen Euryales 12 parts, Rhizoma Dioscoreae 25 parts, Semen Cuscutae 15 parts, Caulis Spatholobi 13 parts, Pericarpium Citri Reticulatae 8 parts, Radix Rehmanniae Preparata 18 parts.
Preparation method: get the Fructus Psoraleae of recipe quantity, Radix Morindae Officinalis, Cortex Acanthopancis add ethanol extraction secondary, each 1 hour, merge extractive liquid, filter, filtrate recycling ethanol, being evaporated to relative density is 1.03 (recording in 60 DEG C), get the Semen Euryales of recipe quantity, Rhizoma Dioscoreae, Semen Cuscutae, Caulis Spatholobi, Pericarpium Citri Reticulatae, Radix Rehmanniae Preparata, decoct with water twice, first time 5 times of the amount of water material total amount of getting it filled that is this step, decoct 2 hours, 3 times of the second time amount of water material total amount of getting it filled that is this step, decoct 1.5 hours, collecting decoction, filter, filtrate reduced in volume, adding ethanol makes alcohol content be 60%, place 12 hours, filter, filtrate recycling ethanol, being concentrated into relative density is 1.01 (recording in 60 DEG C), merge above two kinds of thick pastes, add one or more pharmaceutically acceptable carriers, the conventional method manufacture in field of traditional Chinese medicine pharmacy is adopted to obtain granule.
Embodiment 6
Prescription: Fructus Psoraleae 11 parts, Radix Morindae Officinalis 18 parts, Cortex Acanthopancis 13 parts, Semen Euryales 11 parts, Rhizoma Dioscoreae 25 parts, Semen Cuscutae 9 parts, Caulis Spatholobi 8 parts, Pericarpium Citri Reticulatae 5 parts, Radix Rehmanniae Preparata 15 parts.
Preparation method: get the Fructus Psoraleae of recipe quantity, Radix Morindae Officinalis, Cortex Acanthopancis add ethanol extraction secondary, each 1 hour, merge extractive liquid, filter, filtrate recycling ethanol, being evaporated to relative density is 1.07 (recording in 60 DEG C), get the Semen Euryales of recipe quantity, Rhizoma Dioscoreae, Semen Cuscutae, Caulis Spatholobi, Pericarpium Citri Reticulatae, Radix Rehmanniae Preparata, decoct with water twice, first time 7 times of the amount of water material total amount of getting it filled that is this step, decoct 2.5 hours, 3 times of the second time amount of water material total amount of getting it filled that is this step, decoct 1.5 hours, collecting decoction, filter, filtrate reduced in volume, adding ethanol makes alcohol content be 50%, place 12 hours, filter, filtrate recycling ethanol, being concentrated into relative density is 1.06 (recording in 60 DEG C), merge above two kinds of thick pastes, add one or more pharmaceutically acceptable carriers, the conventional method manufacture in field of traditional Chinese medicine pharmacy is adopted to obtain granule.
Embodiment 7
Prescription: Fructus Psoraleae 16 parts, Radix Morindae Officinalis 23 parts, Cortex Acanthopancis 18 parts, Semen Euryales 16 parts, Rhizoma Dioscoreae 30 parts, Semen Cuscutae 15 parts, Caulis Spatholobi 13 parts, Pericarpium Citri Reticulatae 9 parts, Radix Rehmanniae Preparata 20 parts.
Preparation method: get the Fructus Psoraleae of recipe quantity, Radix Morindae Officinalis, Cortex Acanthopancis add ethanol extraction secondary, each 2 hours, merge extractive liquid, filter, filtrate recycling ethanol, being evaporated to relative density is 1.06 (recording in 60 DEG C), get the Semen Euryales of recipe quantity, Rhizoma Dioscoreae, Semen Cuscutae, Caulis Spatholobi, Pericarpium Citri Reticulatae, Radix Rehmanniae Preparata, decoct with water twice, first time 7 times of the amount of water material total amount of getting it filled that is this step, decoct 3 hours, 4 times of the second time amount of water material total amount of getting it filled that is this step, decoct 1 hour, collecting decoction, filter, filtrate reduced in volume, adding ethanol makes alcohol content be 55%, place 12 hours, filter, filtrate recycling ethanol, being concentrated into relative density is 1.06 (recording in 60 DEG C), merge above two kinds of thick pastes, add one or more pharmaceutically acceptable carriers, the conventional method manufacture in field of traditional Chinese medicine pharmacy is adopted to obtain pill.
Embodiment 8
Prescription: Fructus Psoraleae 14 parts, Radix Morindae Officinalis 20 parts, Cortex Acanthopancis 15 parts, Semen Euryales 13 parts, Rhizoma Dioscoreae 27 parts, Semen Cuscutae 12 parts, Caulis Spatholobi 10 parts, Pericarpium Citri Reticulatae 7 parts, Radix Rehmanniae Preparata 17 parts.
Preparation method: get the Fructus Psoraleae of recipe quantity, Radix Morindae Officinalis, Cortex Acanthopancis add ethanol extraction secondary, each 1 hour, merge extractive liquid, filter, filtrate recycling ethanol, being evaporated to relative density is 1.03 (recording in 60 DEG C), get the Semen Euryales of recipe quantity, Rhizoma Dioscoreae, Semen Cuscutae, Caulis Spatholobi, Pericarpium Citri Reticulatae, Radix Rehmanniae Preparata, decoct with water twice, first time 5 times of the amount of water material total amount of getting it filled that is this step, decoct 2.5 hours, 3 times of the second time amount of water material total amount of getting it filled that is this step, decoct 1.5 hours, collecting decoction, filter, filtrate reduced in volume, adding ethanol makes alcohol content be 50%, place 12 hours, filter, filtrate recycling ethanol, being concentrated into relative density is 1.05 (recording in 60 DEG C), merge above two kinds of thick pastes, add one or more pharmaceutically acceptable carriers, the conventional method manufacture in field of traditional Chinese medicine pharmacy is adopted to obtain oral liquid.
Embodiment 9
Prescription: Fructus Psoraleae 15 parts, Radix Morindae Officinalis 21 parts, Cortex Acanthopancis 15 parts, Semen Euryales 13 parts, Rhizoma Dioscoreae 27 parts, Semen Cuscutae 14 parts, Caulis Spatholobi 12 parts, Pericarpium Citri Reticulatae 7 parts, Radix Rehmanniae Preparata 17 parts.
Preparation method: get the Fructus Psoraleae of recipe quantity, Radix Morindae Officinalis, Cortex Acanthopancis add ethanol extraction secondary, each 1.5 hours, merge extractive liquid, filter, filtrate recycling ethanol, being evaporated to relative density is 1.06 (recording in 60 DEG C), get the Semen Euryales of recipe quantity, Rhizoma Dioscoreae, Semen Cuscutae, Caulis Spatholobi, Pericarpium Citri Reticulatae, Radix Rehmanniae Preparata, decoct with water twice, first time amount of water 5 of the material total amount of getting it filled that is this step, decoct 2 hours, 4 times of the second time amount of water material total amount of getting it filled that is this step, decoct 2 hours, collecting decoction, filter, filtrate reduced in volume, adding ethanol makes alcohol content be 60%, place 12 hours, filter, filtrate recycling ethanol, being concentrated into relative density is 1.08 (recording in 60 DEG C), merge above two kinds of thick pastes, add one or more pharmaceutically acceptable carriers, the conventional method manufacture in field of traditional Chinese medicine pharmacy is adopted to obtain powder.
Claims (7)
1. treat the Chinese medicine composition of kidney-yang deficiency type postmenopausal osteoporosis for one kind, it is characterized in that it is is that medicinal raw material is made by Fructus Psoraleae, Radix Morindae Officinalis, Cortex Acanthopancis, Semen Euryales, Rhizoma Dioscoreae, Semen Cuscutae, Caulis Spatholobi, Pericarpium Citri Reticulatae, Radix Rehmanniae Preparata, and the weight proportion of described each medicinal raw material is as follows: Fructus Psoraleae 11-16 part, Radix Morindae Officinalis 18-23 part, Cortex Acanthopancis 13-18 part, Semen Euryales 11-16 part, Rhizoma Dioscoreae 25-30 part, Semen Cuscutae 9-15 part, Caulis Spatholobi 8-13 part, Pericarpium Citri Reticulatae 5-9 part, Radix Rehmanniae Preparata 15-20 part.
2. Chinese medicine composition as claimed in claim 1, is characterized in that it is made up of the medicinal raw material of weight proportion as described below: Fructus Psoraleae 13-16 part, Radix Morindae Officinalis 18-23 part, Cortex Acanthopancis 14-17 part, Semen Euryales 12-14 part, Rhizoma Dioscoreae 25-30 part, Semen Cuscutae 13-15 part, Caulis Spatholobi 11-13 part, Pericarpium Citri Reticulatae 6-8 part, Radix Rehmanniae Preparata 16-18 part.
3. Chinese medicine composition as claimed in claim 2, is characterized in that it is made up of the medicinal raw material of weight proportion as described below: Fructus Psoraleae 15 parts, Radix Morindae Officinalis 21 parts, Cortex Acanthopancis 15 parts, Semen Euryales 13 parts, Rhizoma Dioscoreae 27 parts, Semen Cuscutae 14 parts, Caulis Spatholobi 12 parts, Pericarpium Citri Reticulatae 7 parts, Radix Rehmanniae Preparata 17 parts.
4. the Chinese medicine composition as described in as arbitrary in claim 1-3, is characterized in that it makes oral formulations.
5. Chinese medicine composition as claimed in claim 4, it is characterized in that the oral formulations that it is made is preferably tablet, capsule, soft capsule, dispersible tablet, oral liquid, granule, chewable tablet, pill, drop pill, slow releasing tablet, slow releasing capsule, controlled release tablet, controlled release capsule, one or more in suspensoid, syrup.
6. Chinese medicine composition as claimed in claim 5, is characterized in that the oral formulations that it is made is preferably tablet, capsule or granule.
7. the Chinese medicine composition as described in as arbitrary in claim 1-6, is characterized in that its preparation method comprises following steps:
1) get the Fructus Psoraleae of recipe quantity, Radix Morindae Officinalis, Cortex Acanthopancis add ethanol extraction secondary, each 1-2 hour, merge extractive liquid, filter, filtrate recycling ethanol, being evaporated to relative density is 1.03-1.10 (recording in 60 DEG C);
2) get the Semen Euryales of recipe quantity, Rhizoma Dioscoreae, Semen Cuscutae, Caulis Spatholobi, Pericarpium Citri Reticulatae, Radix Rehmanniae Preparata, decoct with water twice, first time 5-8 times of the amount of water material total amount of getting it filled that is this step, decoct 2-3 hour, the 3-4 of the second time amount of water material total amount of getting it filled that is this step doubly decocts 1-2 hour, collecting decoction, filtration, filtrate reduced in volume, adding ethanol makes alcohol content be 45-60%, places 12 hours, filters, filtrate recycling ethanol, being concentrated into relative density is 1.01-1.10 (recording in 60 DEG C);
3) merge above two kinds of thick pastes, add one or more pharmaceutically acceptable carriers, adopt the conventional method manufacture in field of traditional Chinese medicine pharmacy to obtain.
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| Title |
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| 谢艳等: "《实用骨伤药膳荟萃》", 31 July 2013, 郑州大学出版社 * |
| 魏珍珍等: ""补肾阳中药治疗围绝经期综合征特点分析"", 《中医学报》 * |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105381042A (en) * | 2015-12-03 | 2016-03-09 | 刘彩虹 | Traditional Chinese medicine composition for treating osteoporosis, preparation method and applications thereof |
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