CN104606279A - Porous nano-sized biological multicalcium and application thereof - Google Patents
Porous nano-sized biological multicalcium and application thereof Download PDFInfo
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- CN104606279A CN104606279A CN201410854119.5A CN201410854119A CN104606279A CN 104606279 A CN104606279 A CN 104606279A CN 201410854119 A CN201410854119 A CN 201410854119A CN 104606279 A CN104606279 A CN 104606279A
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Abstract
The invention aims to provide porous nano-sized biological multicalcium and application thereof. The provided biological multicalcium is absorbed by a human body more easily, is convenient to use, and is safer; the porous nano-sized biological multicalcium is prepared by using a yak bone, hyacinth beans, a turtle shell, a cuttle bone, tortoise plastron and pearl mother as raw materials, and is prepared through performing freeze drying, superfine grinding, enzymolysis, electromagnetic wave treatment and the like to the raw materials. Through application of characteristics of the porous nano-sized biological multicalcium, vitamin D3 is contained into pores of the porous nano-sized biological multicalcium so as to prepare biological calcium D3 tablets, chewable tablets, capsules, granules, suspensions, and calcium-supplementing preparations.
Description
Technical field
The present invention relates to a kind of polynary calcium of nanoporous biological and the application thereof that are easy to human calcium's absorption and improvement.
Background technology
Calcium-supplementing preparation in known technology has more than 400 to plant, and in these calcium-supplementing preparations, selecting, difference on raw material biological calcium availability and absorbance is larger.The biological skeletal calcium wherein selected all contains the heavy metals such as lead, hydrargyrum usually, and long-term taking easily causes in the body of the heavy metal such as lead, hydrargyrum and puts aside, and affects the normal operation of Human Physiology system, even forms secondary poisoning.Calcium is the metallic element that people's in-vivo content is maximum, about has 1200 grams, is also one of element the most easily lacked.Wherein 99% be formed at skeleton, 1% is present in blood soft tissue.Whether calcium deficiency is relevant with two reasons for human body: one is Peak Bone Mass, and namely when one's mid-30s, human body bone amount reaches calcium content during most high bone mass in life, determines primarily of inherited genetic factors, factor of replenishing the calcium and exercise factors; Two is calcium loss situations, determined by the supplementing of calcium, number of dropouts and living habit, as too high addicted to tobacco and wine, coffee, tea, cola, Salt intake, eat meat less or eats the loss that too many meat all can cause calcium.
Edible calsium supplement generally adopts the calcium carbonate of natural origin, comprises limestone and Concha Ostreae.Recommend according to Chinese Soclety of Nutrition, the magnitude of recruitment of adult's one day calcium is at 600mg.But common calcium preparation is not high at absorption of human body availability.Which adds the intake of calcium preparation, most of calcium tablet is still very large, dysphagia or make us uncomfortable.Therefore, the calcium-supplementing preparation adopting some to be easy to human calcium's absorption and to improve, is conducive to the utilization rate of calcium at human body.
Summary of the invention
The invention provides a kind of porous nano biological multielement calcium and application thereof, a kind of be easy to human body supplement calcium absorption with improve biological multielement calcium and application.The surface strength that porous nano biological multielement calcium has had, better can be applied at biomedical sector, and the present invention introduces the Seem Lablab Album seed being rich in Calcium in Plants magnesium on the basis in animal calcium source simultaneously, adopts certain method to be prepared from.
A kind of porous nano biological multielement calcium of the present invention and application thereof, the object of invention is to provide one and is more conducive to absorption of human body, easy to use, the biological multielement calcium that safety is higher, uses adsorptive storage vitamin D3 in the hole of porous nano biological multielement calcium.The biological multielement calcium of porous nano, contributes to dissolving.And the raw material of multi-element biologic calcium comes from organism, itself be easy to absorb, add that vitamin D3 contributes to the absorption of calcium, this then provides one and be more conducive to the polynary calcium of absorption of human body.The raw material of multi-element biologic calcium is rich in animal calcium, Calcium in Plants magnesium.
The preparation method of porous nano biological multielement calcium is as follows:
(1) Os Bovis grunniens 30 ~ 65 parts, 20 ~ 50 parts, Seem Lablab Album, Carapax Trionycis 15 ~ 35 parts, Os Sepiae 10 ~ 30 parts, Carapax et Plastrum Testudinis 5 ~ 15 parts, Concha Margaritifera 40 ~ 80 parts is taken, for subsequent use;
(2) by Os Bovis grunniens, Seem Lablab Album, Carapax Trionycis, Os Sepiae, Carapax et Plastrum Testudinis, Concha Margaritifera in (1), lyophilization at-50 DEG C ~-5 DEG C, micronizing;
(3) in (2), add 6 ~ 15 times of water, homogenate, adds complex enzyme composition, keeps temperature 25 DEG C ~ 50 DEG C, enzymolysis 2h ~ 12h, raised temperature to 100 DEG C, keeps 15min;
(4) in (3), add 2 parts ~ 8 parts phosphoric acid and 3 parts ~ 8 parts calcium bicarbonate, select microwave or electromagnetic wave auxiliary water thermal response 4h ~ 8h;
(5) filter, dry, obtain porous nano biological multielement calcium.
Os Bovis grunniens of the present invention is selected from the fresh skeleton of yak of pollution-free grassland growth, the fresh skeleton of fish shellfish that plant seed taken from by Seem Lablab Album, Carapax Trionycis, Os Sepiae, Carapax et Plastrum Testudinis, Concha Margaritifera are selected from pollution-free Watershed expand.
The preparation method in yak skeleton of the present invention, Carapax Trionycis, Os Sepiae, Carapax et Plastrum Testudinis, Concha Margaritifera biological calcium source, the method is: fresh skeleton or shell are carried out lyophilization, and Seem Lablab Album slow fire is fried to there being burnt odor taste.
The present invention has following effect compared to prior art.
Because Os Bovis grunniens is selected from pollution-free grassland, Carapax Trionycis, Os Sepiae, Carapax et Plastrum Testudinis, Concha Margaritifera calcium source are from pollution-free waters, and plant seed taken from by Seem Lablab Album.All containing enriching calcium source, and the fresh bio skeleton of growth in pollution-free grassland, waters, be the raw material of natural, safe biological calcium, effectively improve the utilization rate of biological calcium, solve the problems such as content of beary metal exceeds standard, Seem Lablab Album provides Calcium in Plants magnesium.For weakening the alkalescence of biological calcium of the present invention, improve active and subtract weakly alkaline impact, on raising absorbance, the present invention contains appropriate active animal calcium and Calcium in Plants magnesium, be designed to supplementary natural complex D3 take simultaneously, safety, efficient, be extremely suitable for child and person in middle and old age replenish the calcium and supplement other nutrients.Active natural complex D3 wherein, can make biological calcium dissolve, and makes the absorption of human body to calcium easier.
Another object of the present invention is to provide the porous nano biological multielement porous nano biological multielement calcium vitamin D3 preparation that calcium prepares.
The preparation method of porous nano biological multielement calcium vitamin D3 solid preparation:
Under room temperature, vitamin D3 0.01 ~ 1 part is dissolved in the organic solvent of 30 ~ 150 parts, and is uniformly mixed with porous nano biological multielement calcium 30 ~ 100 parts; Decompression rotary evaporation falls organic solvent, obtains porous nano biological multielement calcium medicine carrying compositions; Wherein, described organic solvent is methanol, ethanol, acetone or its mixture.
The preparation method of porous nano biological multielement calcium vitamin D3 liquid preparation:
Under room temperature, vitamin D3 0.01 part ~ 1 part is dissolved in 20 ~ 100 parts having in aqueous solution, and is uniformly mixed with porous nano biological multielement calcium 30 ~ 100 parts; Obtain biological calcium D3 liquid preparation.
Porous material absorption technology is used according to porous nano biological multielement calcium medicine carrying compositions of the present invention, utilize porous and the adsorptivity of porous material, prepare vitamin D3 porous nano biological multielement calcium medicine carrying compositions, this preparation method is compared with the preparation method of other vitamin D3 dosage forms, have simple and reliable, reproducible, have no side effect, the advantage that bioavailability is high.
Vitamin D3 porous nano biological multielement calcium medicine carrying compositions provided by the invention comprises vitamin D3, porous nano biological multielement calcium, adopt the preparation of porous nano biological multielement calcium adsorption technology, utilize porous and the adsorptivity of porous nano biological multielement calcium, thus improve bioavailability.Vitamin D3 porous nano biological multielement calcium medicine carrying compositions Thermodynamically stable prepared by the present invention, can improve the stability of medicine, stable under gastrointestinal tract environment, have no side effect, system is uniformly dispersed, and in water, dissolubility improves 2-135 doubly, and bioavailability height 3-55 doubly.
The invention is characterized in and adopt adsorption technology to prepare vitamin D3 porous nano biological multielement calcium medicine carrying compositions, utilize porous and the adsorptivity of porous nano biological multielement calcium, the former medicine of vitamin D3 is made to form nano crystals or amorphous form on porous nano biological multielement calcium surface, the nano-grade medicine of release can effectively improve dissolubility in the water of medicine, thus raising bioavailability, especially porous nano biological multielement calcium is applied in vitamin D3 aspect, after forming composite drug-loaded system, bioavailability improves more obvious compared with other dosage forms of vitamin D3, in water, dissolubility improves 2-135 doubly, bioavailability height 3-55 doubly.The diameter of aspirin particle of vitamin D3 porous nano biological multielement calcium medicine carrying compositions release is little and even, in water, dissolubility is high, there is excellent tissue penetration, the stability of drug particle can be improved, strengthen medicine absorption in vivo, improve drug bioavailability, because it is by forming solid preparation after solid, porous material absorption also drying, be convenient to oral and store, be convenient to be prepared in tablet, chewable tablet, capsule, soft capsule, granule, suspensoid one or more.
Vitamin D3 porous nano biological multielement calcium medicine carrying compositions of the present invention is compared with bibliographical information, as nanometer new technique, porous material absorption rear surface is long-pending to increase, drug loading is larger simultaneously, toxic and side effects is little even to have no side effect, the particle diameter of the former medicine of vitamin D3 reduces, can effectively improve dissolubility in the water of vitamin D3, thus raising bioavailability, can be made into the tablet, chewable tablet, capsule, soft capsule, granule, one or more in suspensoid that are easy to oral, there is industrial probability.Porous nano biological multielement calcium medicine carrying compositions provided by the invention, is especially suitable for vitamin D3, compared with other vitamin D3 dosage forms of prior art, in water dissolubility and bioavailability higher.
Vitamin D3 porous nano biological multielement calcium medicine carrying compositions prepared by the present invention, particle diameter is little, solve the problem of vitamin D3 poorly water-soluble, add the dispersibility of vitamin D3, good stability, vitamin D3 is conducive to the gastrointestinal absorption increase of porous nano biological multielement calcium simultaneously, reaches and porous nano biological multielement calcium meltage is increased, increase the object of its bioavailability.Compared with free drug, oral administration biaavailability is significantly increased.
Specific embodiment
Further illustrate the present invention by way of example, therefore do not limit the present invention in described scope of embodiments.
Specific embodiment 1
The preparation method of porous nano biological multielement calcium is as follows:
(1) Os Bovis grunniens 30 parts, 50 parts, Seem Lablab Album, Carapax Trionycis 15 parts, Os Sepiae 30 parts, Carapax et Plastrum Testudinis 5 parts, Concha Margaritifera 80 parts is taken, for subsequent use;
(2) by Os Bovis grunniens, Seem Lablab Album, Carapax Trionycis, Os Sepiae, Carapax et Plastrum Testudinis, Concha Margaritifera in (1), lyophilization at-10 DEG C, micronizing;
(3) in (2), add 10 times of water, homogenate, adds compound enzyme, keeps temperature 37 DEG C, enzymolysis 4h, raised temperature to 100 DEG C, keeps 15min;
(4) in (3), add 5 parts of phosphoric acid and 5 parts of calcium bicarbonate, select the electromagnetic wave auxiliary water thermal response 6h of 20000MHz wavelength;
(5) filter, dry, obtain porous nano biological multielement calcium.
Described porous nano biological multielement calcium makes biological calcium D3 tablet, and it is prepared by following methods:
Under room temperature, vitamin D3 0.05 part is dissolved in the ethanol of 80 parts, and with above-mentioned porous nano biological multielement calcium 65 parts; Decompression rotary evaporation falls organic solvent, obtains porous nano biological multielement calcium medicine carrying compositions.Add excipient sucrose 2 parts, lactose 2 parts, 2 parts, calcium phosphate, starch 4 parts, disintegrating agent polyvinylpolypyrrolidone 5 parts, hyprolose 5 parts, binding agent sodium carboxymethyl cellulose 10 parts is uniformly mixed, and granulate, tabletting forms porous nano biological multielement calcium and makes biological calcium D3 tablet.
Specific embodiment 2
The preparation method of porous nano biological multielement calcium is as follows:
(1) Os Bovis grunniens 50 parts, 30 parts, Seem Lablab Album, Carapax Trionycis 25 parts, Os Sepiae 20 parts, Carapax et Plastrum Testudinis 15 parts, Concha Margaritifera 50 parts is taken, for subsequent use;
(2) by Os Bovis grunniens, Seem Lablab Album, Carapax Trionycis, Os Sepiae, Carapax et Plastrum Testudinis, Concha Margaritifera in (1), lyophilization at-20 DEG C, micronizing;
(3) in (2), add 10 times of water, homogenate, adds compound enzyme, keeps temperature 37 DEG C, enzymolysis 6h, raised temperature to 100 DEG C, keeps 15min;
(4) in (3), add 2 parts of phosphoric acid and 3 parts of calcium bicarbonate, select 12000Hz wavelengths of electromagnetic auxiliary water thermal response 6h; (5) filter, dry, obtain porous nano biological multielement calcium.
Described porous nano biological multielement calcium makes biological calcium D3 tablet, and it is prepared by following methods:
Under room temperature, vitamin D3 0.02 part is dissolved in the methanol of 100 parts, and with above-mentioned porous nano biological multielement calcium 30 parts; Decompression rotary evaporation falls organic solvent, obtains porous nano biological multielement calcium medicine carrying compositions.Add excipients microcrystalline cellulose 1 part, 1 part, mannitol, 1 part, dextrin, lactose 1 part, disintegrating agent cross-linking sodium carboxymethyl cellulose 10 parts, carboxymethyl starch sodium 10 parts, binding agent 25 is uniformly mixed, and granulate, tabletting forms porous nano biological multielement calcium and makes biological calcium D3 tablet.
Body embodiment 3
The preparation method of porous nano biological multielement calcium is as follows:
(1) Os Bovis grunniens 65 parts, 20 parts, Seem Lablab Album, Carapax Trionycis 35 parts, Os Sepiae 10 parts, Carapax et Plastrum Testudinis 10 parts, Concha Margaritifera 10 parts is taken, for subsequent use;
(2) by Os Bovis grunniens, Seem Lablab Album, Carapax Trionycis, Os Sepiae, Carapax et Plastrum Testudinis, Concha Margaritifera in (1), lyophilization at-50 DEG C, micronizing;
(3) in (2), add 15 times of water, homogenate, adds compound enzyme, keeps temperature 37 DEG C, enzymolysis 10h, raised temperature to 100 DEG C, keeps 15min;
(4) in (3), add 8 parts of phosphoric acid and 8 parts of calcium bicarbonate, select 16000MHz wavelengths of electromagnetic auxiliary water thermal response 8h;
(5) filter, dry, obtain porous nano biological multielement calcium.
Described porous nano biological multielement calcium makes biological calcium D3 tablet, and it is prepared by following methods:
Under room temperature, vitamin D3 1 part is dissolved in the ethanol of 150 parts, and with porous nano biological multielement calcium 100 parts; Decompression rotary evaporation falls organic solvent, obtains porous nano biological multielement calcium medicine carrying compositions.Add excipient 20 parts, disintegrating agent 20 parts, binding agent 20 is uniformly mixed, and granulate, tabletting forms porous nano biological multielement calcium and makes biological calcium D3 tablet.
Specific embodiment 4
The preparation method of porous nano biological multielement calcium is as follows:
(1) Os Bovis grunniens 30 parts, 50 parts, Seem Lablab Album, Carapax Trionycis 15 parts, Os Sepiae 30 parts, Carapax et Plastrum Testudinis 5 parts, Concha Margaritifera 80 parts is taken, for subsequent use;
(2) by Os Bovis grunniens, Seem Lablab Album, Carapax Trionycis, Os Sepiae, Carapax et Plastrum Testudinis, Concha Margaritifera in (1), lyophilization at-10 DEG C, micronizing;
(3) in (2), add 10 times of water, homogenate, adds compound enzyme, keeps temperature 37 DEG C, enzymolysis 4h, raised temperature to 100 DEG C, keeps 15min;
(4) in (3), add 5 parts of phosphoric acid and 5 parts of calcium bicarbonate, select 17000MHz wavelengths of electromagnetic auxiliary water thermal response 6h;
(5) filter, dry, obtain porous nano biological multielement calcium.
Described porous nano biological multielement calcium makes biological calcium D3 chewable tablet, and it is prepared by following methods:
Under room temperature, vitamin D3 0.05 part is dissolved in the ethanol of 80 parts, and with porous nano biological multielement calcium 65 parts; Decompression rotary evaporation falls organic solvent, obtains porous nano biological multielement calcium medicine carrying compositions.Add excipient 10 parts, binding agent 10 is uniformly mixed, and granulate, tabletting forms porous nano biological multielement calcium and makes biological calcium D3 chewable tablet.
Specific embodiment 5
The preparation method of porous nano biological multielement calcium is as follows:
(1) Os Bovis grunniens 50 parts, 30 parts, Seem Lablab Album, Carapax Trionycis 25 parts, Os Sepiae 20 parts, Carapax et Plastrum Testudinis 15 parts, Concha Margaritifera 50 parts is taken, for subsequent use;
(2) by Os Bovis grunniens, Seem Lablab Album, Carapax Trionycis, Os Sepiae, Carapax et Plastrum Testudinis, Concha Margaritifera in (1), lyophilization at-20 DEG C, micronizing;
(3) in (2), add 10 times of water, homogenate, adds compound enzyme, keeps temperature 37 DEG C, enzymolysis 6h, raised temperature to 100 DEG C, keeps 15min;
(4) in (3), add 2 parts of phosphoric acid and 3 parts of calcium bicarbonate, select 11000MHz wavelengths of electromagnetic auxiliary water thermal response 6h;
(5) filter, dry, obtain porous nano biological multielement calcium.
Described porous nano biological multielement calcium makes biological calcium D3 chewable tablet, and it is prepared by following methods:
Under room temperature, vitamin D3 0.02 part is dissolved in the ethanol of 100 parts, and with porous nano biological multielement calcium 30 parts; Decompression rotary evaporation falls organic solvent, obtains porous nano biological multielement calcium medicine carrying compositions.Add excipient 3 parts, binding agent 25 is uniformly mixed, and granulate, tabletting forms porous nano biological multielement calcium and makes biological calcium D3 chewable tablet.
Specific embodiment 6
The preparation method of porous nano biological multielement calcium is as follows:
(1) Os Bovis grunniens 65 parts, 20 parts, Seem Lablab Album, Carapax Trionycis 35 parts, Os Sepiae 10 parts, Carapax et Plastrum Testudinis 10 parts, Concha Margaritifera 10 parts is taken, for subsequent use;
(2) by Os Bovis grunniens, Seem Lablab Album, Carapax Trionycis, Os Sepiae, Carapax et Plastrum Testudinis, Concha Margaritifera in (1), lyophilization at-50 DEG C, micronizing;
(3) in (2), add 15 times of water, homogenate, adds compound enzyme, keeps temperature 37 DEG C, enzymolysis 10h, raised temperature to 100 DEG C, keeps 15min;
(4) in (3), add 8 parts of phosphoric acid and 8 parts of calcium bicarbonate, select 13000MHz wavelengths of electromagnetic auxiliary water thermal response 8h;
(5) filter, dry, obtain porous nano biological multielement calcium.
Described porous nano biological multielement calcium makes biological calcium D3 chewable tablet, and it is prepared by following methods:
Under room temperature, vitamin D3 1 part is dissolved in the ethanol of 150 parts, and with porous nano biological multielement calcium 100 parts; Decompression rotary evaporation falls organic solvent, obtains porous nano biological multielement calcium medicine carrying compositions.Add excipient 20 parts, binding agent 20 is uniformly mixed, and granulate, tabletting forms porous nano biological multielement calcium and makes biological calcium D3 chewable tablet.
Specific embodiment 7
The preparation method of porous nano biological multielement calcium is as follows:
(1) Os Bovis grunniens 30 parts, 50 parts, Seem Lablab Album, Carapax Trionycis 15 parts, Os Sepiae 30 parts, Carapax et Plastrum Testudinis 5 parts, Concha Margaritifera 80 parts is taken, for subsequent use;
(2) by Os Bovis grunniens, Seem Lablab Album, Carapax Trionycis, Os Sepiae, Carapax et Plastrum Testudinis, Concha Margaritifera in (1), lyophilization at-10 DEG C, micronizing;
(3) in (2), add 10 times of water, homogenate, adds compound enzyme, keeps temperature 37 DEG C, enzymolysis 4h, raised temperature to 100 DEG C, keeps 15min;
(4) in (3), add 5 parts of phosphoric acid and 5 parts of calcium bicarbonate, select 14000MHz wavelengths of electromagnetic auxiliary water thermal response 6h;
(5) filter, dry, obtain porous nano biological multielement calcium.
Described porous nano biological multielement calcium makes biological calcium D3 granule, and it is prepared by following methods:
Under room temperature, vitamin D3 0.05 part is dissolved in the ethanol of 80 parts, and with porous nano biological multielement calcium 65 parts; Decompression rotary evaporation falls organic solvent, obtains porous nano biological multielement calcium medicine carrying compositions.Add excipient 10 parts, binding agent 10 is uniformly mixed, and granulation forms porous nano biological multielement calcium and makes biological calcium D3 granule.
Specific embodiment 8
The preparation method of porous nano biological multielement calcium is as follows:
(1) Os Bovis grunniens 50 parts, 30 parts, Seem Lablab Album, Carapax Trionycis 25 parts, Os Sepiae 20 parts, Carapax et Plastrum Testudinis 15 parts, Concha Margaritifera 50 parts is taken, for subsequent use;
(2) by Os Bovis grunniens, Seem Lablab Album, Carapax Trionycis, Os Sepiae, Carapax et Plastrum Testudinis, Concha Margaritifera in (1), lyophilization at-20 DEG C, micronizing;
(3) in (2), add 10 times of water, homogenate, adds compound enzyme, keeps temperature 37 DEG C, enzymolysis 6h, raised temperature to 100 DEG C, keeps 15min;
(4) in (3), add 2 parts of phosphoric acid and 3 parts of calcium bicarbonate, select 15700MHz wavelengths of electromagnetic auxiliary water thermal response 6h;
(5) filter, dry, obtain porous nano biological multielement calcium.
Described porous nano biological multielement calcium makes biological calcium D3 granule, and it is prepared by following methods:
Under room temperature, vitamin D3 0.02 part is dissolved in the ethanol of 100 parts, and with porous nano biological multielement calcium 30 parts; Decompression rotary evaporation falls organic solvent, obtains porous nano biological multielement calcium medicine carrying compositions.Add excipient 3 parts, binding agent 25 is uniformly mixed, and granulation forms porous nano biological multielement calcium and makes biological calcium D3 granule.
Specific embodiment 9
The preparation method of porous nano biological multielement calcium is as follows:
(1) Os Bovis grunniens 65 parts, 20 parts, Seem Lablab Album, Carapax Trionycis 35 parts, Os Sepiae 10 parts, Carapax et Plastrum Testudinis 10 parts, Concha Margaritifera 10 parts is taken, for subsequent use;
(2) by Os Bovis grunniens, Seem Lablab Album, Carapax Trionycis, Os Sepiae, Carapax et Plastrum Testudinis, Concha Margaritifera in (1), lyophilization at-50 DEG C, micronizing;
(3) in (2), add 15 times of water, homogenate, adds compound enzyme, keeps temperature 37 DEG C, enzymolysis 10h, raised temperature to 100 DEG C, keeps 15min;
(4) in (3), add 8 parts of phosphoric acid and 8 parts of calcium bicarbonate, select 10900MHz wavelengths of electromagnetic auxiliary water thermal response 8h;
(5) filter, dry, obtain porous nano biological multielement calcium.
Described porous nano biological multielement calcium makes biological calcium D3 granule, and it is prepared by following methods:
Under room temperature, vitamin D3 1 part is dissolved in the ethanol of 150 parts, and with porous nano biological multielement calcium 100 parts; Decompression rotary evaporation falls organic solvent, obtains porous nano biological multielement calcium medicine carrying compositions.Add excipient 20 parts, binding agent 20 is uniformly mixed, and granulation forms porous nano biological multielement calcium and makes biological calcium D3 granule.
Specific embodiment 10
The preparation method of porous nano biological multielement calcium is as follows:
(1) Os Bovis grunniens 30 parts, 50 parts, Seem Lablab Album, Carapax Trionycis 15 parts, Os Sepiae 30 parts, Carapax et Plastrum Testudinis 5 parts, Concha Margaritifera 80 parts is taken, for subsequent use;
(2) by Os Bovis grunniens, Seem Lablab Album, Carapax Trionycis, Os Sepiae, Carapax et Plastrum Testudinis, Concha Margaritifera in (1), lyophilization at-10 DEG C, micronizing;
(3) in (2), add 10 times of water, homogenate, adds compound enzyme, keeps temperature 37 DEG C, enzymolysis 4h, raised temperature to 100 DEG C, keeps 15min;
(4) in (3), add 5 parts of phosphoric acid and 5 parts of calcium bicarbonate, select 10010MHz wavelengths of electromagnetic auxiliary water thermal response 6h;
(5) filter, dry, obtain porous nano biological multielement calcium.
Described porous nano biological multielement calcium makes biological calcium D3 capsule, and it is prepared by following methods:
Under room temperature, vitamin D3 0.05 part is dissolved in the ethanol of 80 parts, and with porous nano biological multielement calcium 65 parts; Decompression rotary evaporation falls organic solvent, obtains porous nano biological multielement calcium medicine carrying compositions.Add excipient 10 parts, binding agent 10 is uniformly mixed, and granulates, and dress capsule forms porous nano biological multielement calcium and makes biological calcium D3 capsule.
Specific embodiment 11
The preparation method of porous nano biological multielement calcium is as follows:
(1) Os Bovis grunniens 50 parts, 30 parts, Seem Lablab Album, Carapax Trionycis 25 parts, Os Sepiae 20 parts, Carapax et Plastrum Testudinis 15 parts, Concha Margaritifera 50 parts is taken, for subsequent use;
(2) by Os Bovis grunniens, Seem Lablab Album, Carapax Trionycis, Os Sepiae, Carapax et Plastrum Testudinis, Concha Margaritifera in (1), lyophilization at-20 DEG C, micronizing;
(3) in (2), add 10 times of water, homogenate, adds compound enzyme, keeps temperature 37 DEG C, enzymolysis 6h, raised temperature to 100 DEG C, keeps 15min;
(4) in (3), add 2 parts of phosphoric acid and 3 parts of calcium bicarbonate, select 12040MHz wavelengths of electromagnetic auxiliary water thermal response 6h;
(5) filter, dry, obtain porous nano biological multielement calcium.
Described porous nano biological multielement calcium makes biological calcium D3 capsule, and it is prepared by following methods:
Under room temperature, vitamin D3 0.02 part is dissolved in the ethanol of 100 parts, and with porous nano biological multielement calcium 30 parts; Decompression rotary evaporation falls organic solvent, obtains porous nano biological multielement calcium medicine carrying compositions.Add excipient 3 parts, binding agent 25 is uniformly mixed, and granulates, and dress capsule forms porous nano biological multielement calcium and makes biological calcium D3 capsule.
Specific embodiment 12
The preparation method of porous nano biological multielement calcium is as follows:
(1) Os Bovis grunniens 65 parts, 20 parts, Seem Lablab Album, Carapax Trionycis 35 parts, Os Sepiae 10 parts, Carapax et Plastrum Testudinis 10 parts, Concha Margaritifera 10 parts is taken, for subsequent use;
(2) by Os Bovis grunniens, Seem Lablab Album, Carapax Trionycis, Os Sepiae, Carapax et Plastrum Testudinis, Concha Margaritifera in (1), lyophilization at-50 DEG C, micronizing;
(3) in (2), add 15 times of water, homogenate, adds compound enzyme, keeps temperature 37 DEG C, enzymolysis 10h, raised temperature to 100 DEG C, keeps 15min;
(4) in (3), add 8 parts of phosphoric acid and 8 parts of calcium bicarbonate, select 18020MHz wavelengths of electromagnetic auxiliary water thermal response 8h;
(5) filter, dry, obtain porous nano biological multielement calcium.
Described porous nano biological multielement calcium makes biological calcium D3 capsule, and it is prepared by following methods:
Under room temperature, vitamin D3 1 part is dissolved in the ethanol of 150 parts, and with porous nano biological multielement calcium 100 parts; Decompression rotary evaporation falls organic solvent, obtains porous nano biological multielement calcium medicine carrying compositions.Add excipient 20 parts, binding agent 20 is uniformly mixed, and granulates, and dress capsule forms porous nano biological multielement calcium and makes biological calcium D3 capsule.
Specific embodiment 13
The preparation method of porous nano biological multielement calcium is as follows:
(1) Os Bovis grunniens 30 parts, 50 parts, Seem Lablab Album, Carapax Trionycis 15 parts, Os Sepiae 30 parts, Carapax et Plastrum Testudinis 5 parts, Concha Margaritifera 80 parts is taken, for subsequent use;
(2) by Os Bovis grunniens, Seem Lablab Album, Carapax Trionycis, Os Sepiae, Carapax et Plastrum Testudinis, Concha Margaritifera in (1), lyophilization at-10 DEG C, micronizing;
(3) in (2), add 10 times of water, homogenate, adds compound enzyme, keeps temperature 37 DEG C, enzymolysis 4h, raised temperature to 100 DEG C, keeps 15min;
(4) in (3), add 5 parts of phosphoric acid and 5 parts of calcium bicarbonate, select 15000MHz wavelengths of electromagnetic auxiliary water thermal response 6h;
(5) filter, dry, obtain porous nano biological multielement calcium.
Described porous nano biological multielement calcium makes biological calcium D3 soft capsule, and it is prepared by following methods:
Under room temperature, vitamin D3 0.05 part is dissolved in the ethanol of 80 parts, and with porous nano biological multielement calcium 65 parts; Decompression rotary evaporation falls organic solvent, obtains porous nano biological multielement calcium medicine carrying compositions.Add excipient 10 parts, binding agent 10 is uniformly mixed, and granulates, forms porous nano biological multielement calcium and make biological calcium D3 soft capsule in soft capsule.
Specific embodiment 14
The preparation method of porous nano biological multielement calcium is as follows:
(1) Os Bovis grunniens 50 parts, 30 parts, Seem Lablab Album, Carapax Trionycis 25 parts, Os Sepiae 20 parts, Carapax et Plastrum Testudinis 15 parts, Concha Margaritifera 50 parts is taken, for subsequent use;
(2) by Os Bovis grunniens, Seem Lablab Album, Carapax Trionycis, Os Sepiae, Carapax et Plastrum Testudinis, Concha Margaritifera in (1), lyophilization at-20 DEG C, micronizing;
(3) in (2), add 10 times of water, homogenate, adds compound enzyme, keeps temperature 37 DEG C, enzymolysis 6h, raised temperature to 100 DEG C, keeps 15min;
(4) in (3), add 2 parts of phosphoric acid and 3 parts of calcium bicarbonate, select 10300MHz wavelengths of electromagnetic auxiliary water thermal response 6h;
(5) filter, dry, obtain porous nano biological multielement calcium.
Described porous nano biological multielement calcium makes biological calcium D3 soft capsule, and it is prepared by following methods:
Under room temperature, vitamin D3 0.02 part is dissolved in the ethanol of 100 parts, and with porous nano biological multielement calcium 30 parts; Decompression rotary evaporation falls organic solvent, obtains porous nano biological multielement calcium medicine carrying compositions.Add excipient 3 parts, binding agent 25 is uniformly mixed, and granulates, and dress capsule forms porous nano biological multielement calcium and makes the soft wafer of biological calcium D3.
Specific embodiment 15
The preparation method of porous nano biological multielement calcium is as follows:
(1) Os Bovis grunniens 65 parts, 20 parts, Seem Lablab Album, Carapax Trionycis 35 parts, Os Sepiae 10 parts, Carapax et Plastrum Testudinis 10 parts, Concha Margaritifera 10 parts is taken, for subsequent use;
(2) by Os Bovis grunniens, Seem Lablab Album, Carapax Trionycis, Os Sepiae, Carapax et Plastrum Testudinis, Concha Margaritifera in (1), lyophilization at-50 DEG C, micronizing;
(3) in (2), add 15 times of water, homogenate, adds compound enzyme, keeps temperature 37 DEG C, enzymolysis 10h, raised temperature to 100 DEG C, keeps 15min;
(4) in (3), add 8 parts of phosphoric acid and 8 parts of calcium bicarbonate, select 10200MHz wavelengths of electromagnetic auxiliary water thermal response 8h;
(5) filter, dry, obtain porous nano biological multielement calcium.
Described porous nano biological multielement calcium makes biological calcium D3 capsule, and it is prepared by following methods:
Under room temperature, vitamin D3 1 part is dissolved in the ethanol of 150 parts, and with porous nano biological multielement calcium 100 parts; Decompression rotary evaporation falls organic solvent, obtains porous nano biological multielement calcium medicine carrying compositions.Add excipient 20 parts, binding agent 20 is uniformly mixed, and granulates, and dress capsule forms porous nano biological multielement calcium and makes biological calcium D3 capsule.
Specific embodiment 16
The preparation method of porous nano biological multielement calcium is as follows:
(1) Os Bovis grunniens 30 parts, 50 parts, Seem Lablab Album, Carapax Trionycis 15 parts, Os Sepiae 30 parts, Carapax et Plastrum Testudinis 5 parts, Concha Margaritifera 80 parts is taken, for subsequent use;
(2) by Os Bovis grunniens, Seem Lablab Album, Carapax Trionycis, Os Sepiae, Carapax et Plastrum Testudinis, Concha Margaritifera in (1), lyophilization at-10 DEG C, micronizing;
(3) in (2), add 10 times of water, homogenate, adds compound enzyme, keeps temperature 37 DEG C, enzymolysis 4h, raised temperature to 100 DEG C, keeps 15min;
(4) in (3), add 5 parts of phosphoric acid and 5 parts of calcium bicarbonate, select 15130MHz wavelengths of electromagnetic auxiliary water thermal response 6h;
(5) filter, dry, obtain porous nano biological multielement calcium.
Described porous nano biological multielement calcium makes biological calcium D3 suspension, and it is prepared by following methods:
Under room temperature, vitamin D3 0.05 part is dissolved in the aqueous solution of 80 parts, and with porous nano biological multielement calcium 65 parts; Obtain porous nano biological multielement calcium D3 suspension.
Specific embodiment 17
The preparation method of porous nano biological multielement calcium is as follows:
(1) Os Bovis grunniens 50 parts, 30 parts, Seem Lablab Album, Carapax Trionycis 25 parts, Os Sepiae 20 parts, Carapax et Plastrum Testudinis 15 parts, Concha Margaritifera 50 parts is taken, for subsequent use;
(2) by Os Bovis grunniens, Seem Lablab Album, Carapax Trionycis, Os Sepiae, Carapax et Plastrum Testudinis, Concha Margaritifera in (1), lyophilization at-20 DEG C, micronizing;
(3) in (2), add 10 times of water, homogenate, adds compound enzyme, keeps temperature 37 DEG C, enzymolysis 6h, raised temperature to 100 DEG C, keeps 15min;
(4) in (3), add 2 parts of phosphoric acid and 3 parts of calcium bicarbonate, select 15100MHz wavelengths of electromagnetic auxiliary water thermal response 6h;
(5) filter, dry, obtain porous nano biological multielement calcium.
Described porous nano biological multielement calcium makes biological calcium D3 suspension, and it is prepared by following methods:
Under room temperature, vitamin D3 0.02 part is dissolved in the aqueous solution of 100 parts, and is uniformly mixed with porous nano biological multielement calcium 30 parts; Obtain porous nano biological multielement calcium D3 suspension.
Specific embodiment 18
The preparation method of porous nano biological multielement calcium is as follows:
(1) Os Bovis grunniens 65 parts, 20 parts, Seem Lablab Album, Carapax Trionycis 35 parts, Os Sepiae 10 parts, Carapax et Plastrum Testudinis 10 parts, Concha Margaritifera 10 parts is taken, for subsequent use;
(2) by Os Bovis grunniens, Seem Lablab Album, Carapax Trionycis, Os Sepiae, Carapax et Plastrum Testudinis, Concha Margaritifera in (1), lyophilization at-50 DEG C, micronizing;
(3) in (2), add 15 times of water, homogenate, adds compound enzyme, keeps temperature 37 DEG C, enzymolysis 10h, raised temperature to 100 DEG C, keeps 15min;
(4) in (3), add 8 parts of phosphoric acid and 8 parts of calcium bicarbonate, select 10300MHz wavelengths of electromagnetic auxiliary water thermal response 8h;
(5) filter, dry, obtain porous nano biological multielement calcium.
Described porous nano biological multielement calcium makes biological calcium D3 suspension, and it is prepared by following methods:
Under room temperature, vitamin D3 1 part is dissolved in the aqueous solution of 150 parts, and is uniformly mixed with porous nano biological multielement calcium 100 parts; Obtain porous nano biological multielement calcium D3 suspension.
Experimental example 1
Get this product, according to dissolution method (Chinese Pharmacopoeia version in 2010 two annex Ⅹ C second methods), with hydrochloric acid solution (0.1mol/L) 900ml for dissolution medium, rotating speed is 50 turns per minute, operate in accordance with the law, through 30 minutes time, get solution appropriate, filter, precision measures subsequent filtrate 50ml, add water 100ml, and sodium hydroxide solution 10ml and hydroxynaphthol blue indicator are about 0.3g, is titrated to solution changes pure blue into by aubergine with Calcium Disodium Versenate volumetric solution (0.05mol/L).Every 1ml Calcium Disodium Versenate volumetric solution (0.05mol/L) is equivalent to the Ca of 2.004mg, and calculate the stripping quantity of every sheet/grain/bag, limit is 85% of labelled amount, should conform with the regulations.Concrete outcome is in table 1.
Table 1 dissolution test result
Claims (9)
1. a porous nano biological multielement calcium, is characterized in that comprising following raw material:
Os Bovis grunniens 30 ~ 65 parts
20 ~ 50 parts, Seem Lablab Album
Carapax Trionycis 15 ~ 35 parts
Os Sepiae 10 ~ 30 parts
Carapax et Plastrum Testudinis 5 ~ 15 parts
Concha Margaritifera 40 ~ 80 parts.
2. a porous nano biological multielement calcium, is characterized in that comprising following raw material:
Os Bovis grunniens 45 ~ 55 parts
30 ~ 40 parts, Seem Lablab Album
Carapax Trionycis 25 ~ 30 parts
Os Sepiae 15 ~ 20 parts
Carapax et Plastrum Testudinis 8 ~ 12 parts
Concha Margaritifera 55 ~ 65 parts.
3. the preparation method of a kind of porous nano biological multielement calcium as described in claim 1-2, is characterized in that comprising the steps:
(1) Os Bovis grunniens 30 ~ 65 parts, 20 ~ 50 parts, Seem Lablab Album, Carapax Trionycis 15 ~ 35 parts, Os Sepiae 10 ~ 30 parts, Carapax et Plastrum Testudinis 5 ~ 15 parts, Concha Margaritifera 40 ~ 80 parts is taken, for subsequent use;
(2) by Os Bovis grunniens, Seem Lablab Album, Carapax Trionycis, Os Sepiae, Carapax et Plastrum Testudinis, Concha Margaritifera in (1), lyophilization at-50 DEG C ~-5 DEG C, micronizing;
(3) in (2), add 6 ~ 15 times of water, homogenate, adds complex enzyme composition, keeps temperature 25 DEG C ~ 50 DEG C, enzymolysis 2h ~ 12h, raised temperature to 100 DEG C, keeps 15min;
(4) in (3), add 2 parts ~ 8 parts phosphoric acid and 3 parts ~ 8 parts calcium bicarbonate, select 10000 ~ 20000MHz wavelengths of electromagnetic auxiliary water thermal response 4h ~ 8h;
(5) filter, dry, pulverize, obtain porous nano biological multielement calcium.
4. complex enzyme composition is pepsin, trypsin, lipase, collagenase, hyaluronidase and saccharomycetic mixture as described in claim 3, described pepsin: trypsin: lipase: collagenase: hyaluronidase: saccharomycetic weight ratio is 1:0.45:3.3:1.5:2.8:0.08.
5. a kind of porous nano biological multielement calcium as described in claim 1-4, described porous nano biological multielement calcium makes biological calcium D3 tablet, and it is prepared by following formula:
Porous nano biological multielement calcium 30 ~ 100 parts
Vitamin D3 0.01 ~ 1 part
Excipient 1 ~ 20 part
Disintegrating agent 1 ~ 20 part
Binding agent 1 ~ 20 part;
Described excipient is one or more in sucrose, lactose, microcrystalline Cellulose, dextrin, mannitol, starch or calcium phosphate; Described disintegrating agent is one or more in hyprolose, carboxymethyl starch sodium, polyvinylpolypyrrolidone or cross-linking sodium carboxymethyl cellulose; Described binding agent is polyvinylpyrrolidone, sodium carboxymethyl cellulose, one or more in starch; Described preparation method: under room temperature, is dissolved in vitamin D3 0.01 ~ 1 part in the organic solvent of 80 ~ 150 parts, and is uniformly mixed with porous nano biological multielement calcium 30 ~ 100 parts, and decompression rotary evaporation removing organic solvent, obtains the composite drug-loaded compositions of porous; Composite drug-loaded for gained porous compositions and excipient 1 ~ 20 part, disintegrating agent 1 ~ 20 part are mixed homogeneously, adds binding agent 1 ~ 20 part, granulate, dry, be pressed into biological calcium D3 tablet; Wherein, described organic solvent is methanol, ethanol, acetone or its mixture.
6. a kind of porous nano biological multielement calcium as described in claim 1-4, described porous nano biological multielement calcium makes biological calcium D3 chewable tablet, and it is prepared by following formula:
Porous nano biological multielement calcium 30 ~ 100 parts
Vitamin D3 0.01 ~ 1 part
Excipient 1 ~ 25 part
Binding agent 1 ~ 25 part;
Described excipient is one or more in sucrose, lactose, microcrystalline Cellulose, dextrin, mannitol, starch or calcium phosphate; Described binding agent is polyvinylpyrrolidone, sodium carboxymethyl cellulose, one or more in starch; Described preparation method: under room temperature, is dissolved in vitamin D3 0.01 ~ 1 part in the organic solvent of 80 ~ 150 parts, and is uniformly mixed with porous nano biological multielement calcium 30 ~ 100 parts, and decompression rotary evaporation falls organic solvent, obtains the composite drug-loaded compositions of porous; Composite drug-loaded for gained porous compositions and excipient 1 ~ 25 part is mixed homogeneously, adds binding agent 1 ~ 25 part, granulate, dry, be pressed into biological calcium D3 chewable tablet; Wherein, described organic solvent is methanol, ethanol, acetone or its mixture.
7. a kind of porous nano biological multielement calcium as described in claim 1-4, described porous nano biological multielement calcium makes biological calcium D3 granule, and it is prepared by following formula:
Porous nano biological multielement calcium 30 ~ 100 parts
Vitamin D3 0.01 ~ 1 part
Excipient 1 ~ 30 part
Binding agent 1 ~ 30 part;
Described excipient is one or more in sucrose, lactose, microcrystalline Cellulose, dextrin, mannitol, starch or calcium phosphate; Described binding agent is polyvinylpyrrolidone, sodium carboxymethyl cellulose, one or more in starch; Described preparation method: under room temperature, is dissolved in vitamin D3 0.01 ~ 1 part in the organic solvent of 30 ~ 100 parts, and is uniformly mixed with porous nano biological multielement calcium 30 ~ 100 parts, and decompression rotary evaporation falls organic solvent, obtains the composite drug-loaded compositions of porous; Composite drug-loaded for gained porous compositions and excipient 1 ~ 30 part is mixed homogeneously, adds binding agent 1 ~ 30 part, granulate, dry, make biological calcium D3 granule; Wherein, described organic solvent is methanol, ethanol, acetone or its mixture.
8. a kind of porous nano biological multielement calcium as described in claim 1-4, described porous nano biological multielement calcium makes biological calcium D3 capsule, and it is prepared by following formula:
Porous nano biological multielement calcium 30 ~ 100 parts
Vitamin D3 0.01 ~ 1 part
Excipient 1 ~ 30 part
Binding agent 1 ~ 30 part;
Described excipient is one or more in sucrose, lactose, microcrystalline Cellulose, dextrin, mannitol, starch or calcium phosphate; Described binding agent is polyvinylpyrrolidone, sodium carboxymethyl cellulose, one or more in starch; Described preparation method: under room temperature, vitamin D3 0.01 part ~ 1 part is dissolved in the organic solvent of 30 ~ 100 parts, and be uniformly mixed with porous nano biological multielement calcium 30 parts ~ 100 parts, decompression rotary evaporation falls organic solvent, obtains the composite drug-loaded compositions of porous; Mixed homogeneously by composite drug-loaded for gained porous compositions and excipient 1 part ~ 30 parts, add binding agent 1 part ~ 30 parts, granulate, dry, filled capsules, makes biological calcium D3 capsule; Wherein, described organic solvent is methanol, ethanol, acetone or its mixture.
9. a kind of porous nano biological multielement calcium as described in claim 1-4, wherein, described porous nano biological multielement calcium makes biological calcium D3 suspension, and it is prepared by following formula:
Porous nano biological multielement calcium 20 parts ~ 100 parts;
Vitamin D3 0.01 part ~ 1 part;
Described preparation method: under room temperature, vitamin D3 0.01 part ~ 1 part is dissolved in the organic solvent of 20 ~ 100 parts, and be uniformly mixed with porous nano biological multielement calcium 30 parts ~ 100 parts, decompression rotary evaporation falls organic solvent, obtains the composite drug-loaded compositions of porous; Composite drug-loaded for gained porous compositions dropped in 30 ~ 100 parts of aqueous solutions, dispersed with stirring is even, makes biological calcium D3 granule; Wherein, described organic solvent is methanol, ethanol, acetone or its mixture.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000044681A2 (en) * | 1999-02-01 | 2000-08-03 | The Curators Of The University Of Missouri | Method for preparing porous shells or gels from glass particles |
| CN1672740A (en) * | 2005-04-25 | 2005-09-28 | 浙江大学 | Degradable biomedicine composite material in nanometer structure and its prepn process |
| CN103351016A (en) * | 2013-06-27 | 2013-10-16 | 浙江理工大学 | Method for preparing globular porous calcium carbonate granules |
-
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- 2014-12-31 CN CN201410854119.5A patent/CN104606279B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000044681A2 (en) * | 1999-02-01 | 2000-08-03 | The Curators Of The University Of Missouri | Method for preparing porous shells or gels from glass particles |
| CN1672740A (en) * | 2005-04-25 | 2005-09-28 | 浙江大学 | Degradable biomedicine composite material in nanometer structure and its prepn process |
| CN103351016A (en) * | 2013-06-27 | 2013-10-16 | 浙江理工大学 | Method for preparing globular porous calcium carbonate granules |
Non-Patent Citations (3)
| Title |
|---|
| WEI GUAN,等: "A Novel Synthesis Method of Porous Calcium Silicate Hydrate Based on the Calcium Oxide/Polyethylene Glycol Composites", 《JOURNAL OF NANOMATERIALS》 * |
| 沈奇，等: "扁豆的研究概况", 《金陵科技学院学报》 * |
| 蒋金来，等。: "钙制剂研究进展", 《食品工业科技》 * |
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Address after: 528449 12 Southern China modern Chinese medicine city, Nan Lang Town, Zhongshan, Guangdong. Patentee after: Guoyuan Guoyao (Guangdong) Pharmaceutical Group Co.,Ltd. Address before: 528449 12 Southern China modern Chinese medicine city, Nan Lang Town, Zhongshan, Guangdong. Patentee before: GUANGDONG GUOYUAN GUOYAO PHARMACEUTICAL Co.,Ltd. |