CN104605861B - The test system and method that the photo-induced sense of hearing is affected by a kind of beam shaping - Google Patents
The test system and method that the photo-induced sense of hearing is affected by a kind of beam shaping Download PDFInfo
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- CN104605861B CN104605861B CN201510009582.4A CN201510009582A CN104605861B CN 104605861 B CN104605861 B CN 104605861B CN 201510009582 A CN201510009582 A CN 201510009582A CN 104605861 B CN104605861 B CN 104605861B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/12—Audiometering
- A61B5/121—Audiometering evaluating hearing capacity
- A61B5/125—Audiometering evaluating hearing capacity objective methods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
Abstract
The invention discloses the test system and method that the photo-induced sense of hearing is affected by a kind of beam shaping, including the exciting signal source being sequentially connected, light source and driving module, Transmission Fibers, mode switch module, the optical signal of Optical Fiber Transmission is flowed to light beam and assembles Shaping Module or beam divergence module by mode switch module, it is achieved divergent beams and the switching assembled between light beam；Light beam is assembled the output illumination of Shaping Module or beam divergence module and is penetrated for testing the animal auditory test module that animal auditory is organized in divergent beams and assembles auditory response corresponding with alternative sounds under light beam, the data recorded are transferred to data processing module by animal auditory test module, data processing module is responsible for processing the auditory response signal collected, and obtains divergent beams and assembles the difference that light beam can induce the optical signal parameters of auditory response.This test system and method is used for photo-induced auditory system research, can test or demarcate shaping light beam and bring the change of system signal parameter.
Description
Technical field
The invention discloses the test system and method that the photo-induced sense of hearing is affected by a kind of beam shaping.
Background technology
Recent researches shows, light pulse replaces electric pulse can excite the conduction function of animal auditory nerve, has the potential quality repairing the sense of hearing for artificial cochlea.Fiber pulse laser irradiates cochlea auditory nerve tissue can produce optoacoustic effect phenomenon, and this effect can observe the acous reaction of laser triggering by measuring animal ABR (ABR).Knowable to this kind of Research Literature is reported, the laser of existing multi-wavelength successfully induces the sense of hearing, such as 808nm, 980nm, 1850nm etc., also have the impact of people's Study of Laser other Parameters variation (such as pulsewidth, pulse recurrence rate etc.) photic stimuli induction sense of hearing simultaneously.
Laser needs to enter animal cochlea after transmission medium couples, and optical fiber is a kind of fiber being made up of glass or plastics, utilizes the total reflection principle conduction laser of light, is the material preferably transmitting laser.Current research report all uses the fiber optic conduction optical signal (such as 200um, 100um or thinner) that core diameter is thinner, and light beam is not done any process by fiber outlet, can be described as naked port, this port may bring series of problems in beam Propagation:
1, laser beam divergence change causes greatly laser energy to dissipate, and laser action region expands, and makes light stimulus precise decreasing, it is impossible to determine accurate stimulation location.
2, under equal conditions, the laser power of large energy need to be used just to induce hearing phenomenon, be unfavorable for LASER Light Source, the miniaturization of DWDM driver circuits structure.
3, the distance of bare optical port placement and angle and photo-induced auditory effect height correlation, it is not easy to accurately control.
4, bare optical port is easily subject to the pollution of aural tissue liquid, easily causes blocking, hinders the output of light, fiber port can be caused when blocking serious to damage.
Summary of the invention
In order to solve the defect that prior art exists, the invention discloses the test system and method that the photo-induced sense of hearing is affected by a kind of beam shaping.
The technical solution used in the present invention is as follows:
The test system that the photo-induced sense of hearing is affected by a kind of beam shaping, including the exciting signal source being sequentially connected, light source and driving module, Transmission Fibers, mode switch module, animal auditory test module and data processing module；The optical signal that the animal auditory tissue that Transmission Fibers is transmitted by described mode switch module can identify flows to light beam and assembles Shaping Module or beam divergence module, it is achieved divergent beams and the switching assembled between light beam；Described light beam is assembled the output illumination of Shaping Module or beam divergence module and is penetrated animal auditory tissue relevant position, use animal auditory test module to test animal auditory and be organized in the auditory response signal of induction under gathering light beam and divergent beams, the auditory response data recorded are transferred to data processing module by described animal auditory test module, described data processing module is responsible for processing the auditory response signal collected, com-parison and analysis divergent beams and the difference of gathering optical beam induced auditory response.
Described exciting signal source, for modulated light source and drive module can activate the optical signal of animal auditory tissue to produce；For output parameter adjustable excitation electric signal generator, or sound is divided frequency range by the logarithmic scale meeting human hearing characteristic, after being processed by equipment, be converted to the Sound Processor Unit of the signal of telecommunication of each passage.
Described light source and driving module, be used for producing optical signal, for LED light source, continuous or pulse laser and the drive circuit controlling light source.
Described continuous or pulse laser is gas laser, solid state laser or liquid laser.
Described Transmission Fibers, the various optical fiber of the optical signal for producing for transmission light source and driving module, such as: step index fiber or graded fiber, single-mode fiber or multimode fibre, etc..
Described mode switch module, it is achieved light beam assembles the mutual switching between Shaping Module and beam divergence module；The mode realized is: realizes Transmission Fibers by an exchanging structure and assembles the mutual switching between Shaping Module and beam divergence module at light beam, or the mode using Transmission Fibers directly fused with the optical fiber pigtail of light beam gathering Shaping Module or beam divergence module realizes mutually switching.
Described animal auditory test module, is organized in light beam gathering Shaping Module for testing animal auditory and exports the auditory response that different optical signals produce under beam divergence module；It includes a testing cassete and an Auditory eletrophysiology measuring instrument, tested animal auditory tissue fixing after holding anesthesia in described testing cassete；The cochlea corresponding phonosensitive position of described tested animal auditory tissue produces corresponding auditory response under different optical signals irradiate, and can measure its auditory response by Auditory eletrophysiology measuring instrument.
Described beam divergence module, does not does any process for port, directly exports the naked fiber port of optical signal.
Described light beam assembles Shaping Module, and including a naked fiber port, the signal output part at naked fiber port is provided with an optical shaping element, by optical shaping element, is the light beam that collimation is good, the angle of divergence is little by beam shaping bigger for the angle of divergence.
Described light beam assembles Shaping Module and beam divergence module is arranged on an adjustable support for the accurately three-dimensional coordinate of regulation output beam.
Described data processing module is responsible for processing the auditory response signal collected, and processes through Auditory eletrophysiology measuring instrument, record experiment curv or data, and computer analysis of restoring contrasts, draws the difference of the forward and backward optical signal parameters inducing auditory response of beam shaping.
The method that the test system that the photo-induced sense of hearing is affected by described beam shaping is tested is as follows:
The signal of telecommunication of step 1. exciting signal source output under electrical control circuit effect, converts the electrical signal to the light pulse signal of correspondence, in optical signal coupled feeding output optical fibre in light source and driving module；
Step 2. tests the light beam assembling the Shaping Module light path output different with beam divergence module through light beam；Under identical exciting signal source drives, the optical signal power of generation is without substantially loss, to verify that beam shaping processes the non-destructive to light output.
Step 3. makes the animal in described animal auditory test module treat that audiometry irradiated tissue position spills cruelly；
Step 4. is assigned and checks the measurement electrode of animal auditory electrophysiologicalmeasurements measurements instrument in testing cassete；
Step 5. carries out light path light beam and assembles Shaping Module and the switching of beam divergence module, fixes irradiating optical fiber with adjustable fixed support, keeps stablizing of the distance between optical fiber light-emitting window and the illuminated position of aural tissue and hot spot；
Step 6. sets exciting signal source and light source and drives the parameter of module, implements optical signal and irradiates；
Step 7. opens Auditory eletrophysiology measuring instrument, and record measured waveform also preserves；
Step 8. is under the conditions of each group of pumping signal and different range finding, measure light beam successively and assemble the auditory response curve under Shaping Module and beam divergence module, and data are analyzed, draw the difference of the forward and backward optical signal parameters inducing auditory response of beam shaping.
Beneficial effects of the present invention is as follows:
The present invention has regioselectivity according to the topological structure of the distribution of animal i-coch phonosensitive auditory nerve and conduction, propose beam shaping to improve optical signal and stimulate selective imagination, and design and a kind of detect the test system and method that the photo-induced sense of hearing is affected by beam shaping；The beam shaping of fiber-optic output mouth, lossless to optical signal, but laser beam divergence can be reduced, by the switching of optical fiber output light path, compare the change that different light paths pattern can induce the optical signal parameters of animal auditory reaction.Compared with the output of bare optical port, the laser delivery efficiency after shaping is higher, and the laser power threshold needed for inspiring animal auditory reaction is lower；Meanwhile, under same luminous power, fiber-optic output mouth and the distance of auditory nerve tissue can closely can be remote, auditory response can be induced equally.
This test system and method is used for photo-induced auditory system research, can test or demarcate shaping light beam and bring the change of system signal parameter.Beam shaping is conducive to optical signal selectivity in cochlea on audiofrequency, it is easy to apparatus system minimizes, the flexible control of the light beam of collimation, beneficially operating distance.
Accompanying drawing explanation
Fig. 1 tests system and constitutes block diagram；
Fig. 2 (a) is transmission schematic diagram before beam shaping；
Fig. 2 (b) is transmission schematic diagram after beam shaping；
Fig. 3 animal auditory test module diagram.
Fig. 4 light beam aggregation bunch affects situation with dissipating to hot spot (i.e. light beam zone of action selectivity)；
Under the identical light intensity of Fig. 5, light beam is assembled and dissipates the OABR signal strength signal intensity of generation and the relation of light action distance.
Detailed description of the invention
The present invention is described in detail below in conjunction with the accompanying drawings:
As it is shown in figure 1, the test system that the photo-induced sense of hearing is affected by beam shaping, this test system is used for photo-induced auditory system research, can test or demarcate shaping light beam and bring the change of system signal parameter.Beam shaping is conducive to optical signal selectivity in cochlea on audiofrequency, it is easy to apparatus system minimizes, the flexible control of the light beam of collimation, beneficially operating distance, and concrete structure is as follows:
It includes the exciting signal source being sequentially connected, light source and drives module, Transmission Fibers, mode switch module, the optical signal of Optical Fiber Transmission is flowed to light beam and assembles Shaping Module or beam divergence module by mode switch module, it is achieved divergent beams and the switching assembled between light beam；Light beam is assembled the output illumination of Shaping Module or beam divergence module and is penetrated the animal auditory test module for testing the auditory response that animal auditory is organized under divergent beams and gathering light beam, the data recorded are transferred to data processing module by animal auditory test module, described data processing module is responsible for processing the auditory response signal collected, and analyzes and draws divergent beams and assemble the difference that light beam can induce the optical signal parameters of auditory response.
In this system, the beam shaping of fiber-optic output mouth, lossless to optical signal, but can reduce laser beam divergence, by the switching of optical fiber output light path, compares the change that different light paths pattern can induce the optical signal parameters of animal auditory reaction.Under same luminous power, compared with the output of bare optical port, the laser delivery efficiency after shaping is higher, the auditory response response curve inspired is more preferably, meanwhile, the distance of fiber-optic output mouth and auditory nerve tissue more flexible (can closely can be far), as shown in Figure 5.
Exciting signal source is signal generator, the signal generator output parameter adjustable excitation signal of telecommunication, or Sound Processor Unit, sound is divided frequency range by the logarithmic scale meeting human hearing characteristic by Sound Processor Unit, after a series of process such as band-pass filter group filtering, be converted to the signal of telecommunication of each passage.
The stimulus signal of exciting signal source output, is used for modulating corresponding light source drive circuit to produce corresponding optical signal.
Light source and driving module can be LED light source, continuous or pulse laser
Continuous or pulse laser is gas laser, solid state laser or liquid laser；Solid state laser includes semiconductor laser.
Transmission Fibers can be that various types of optical fiber is (such as step index fiber, graded fiber；Single mode or multimode fibre etc.).
Mode switch module: Transmission Fibers is connected with the fiber-optic output mouth of different mode by exchanging structure；Pattern includes: pattern 1: the diverging light that the light of Optical Fiber Transmission directly exports from naked port；Pattern 2: the gathering light that the light of Optical Fiber Transmission exports after beam shaping processes again.
Exchanging structure can use general optical fiber coupling device, wherein comprises multiple, such as SC fiber coupler, FC fiber coupler, LC fiber coupler, ST fiber coupler；May be used without Transmission Fibers directly fused with the optical fiber pigtail of band model 1 or pattern 2.
Light beam assembles Shaping Module and beam divergence module is sequentially arranged on an adjustable fixed support, for regulating the three-dimensional coordinate of optical fiber output beam, makes hot spot be directed at irradiation position, and fixed support can be various types of three dimension stereo positioner；Light beam is assembled Shaping Module and beam divergence module and is arranged in the z-axis of three dimension stereo positioner by an adjustable fibre clip, and fibre clip is the most adjustable.
As shown in Fig. 2 (b), light beam assembles Shaping Module, and the light beam exporting optical fiber carries out the optical texture of shaping；By optical shaping element or structure, by light beam bigger for the angle of divergence, it is shaped as the light beam that collimation is preferable, the angle of divergence is less, makes light beam (such as zero micron～tens millimeters) in certain transmission range the most substantially be lost, it is to avoid beam divergence.Light beam assembles the optical shaping element of Shaping Module employing can be multiple, such as gradual index lens, fixed refraction lens, self-focusing optical fiber etc.；Reshaping structure can be realized by optical fiber processing technique；
As shown in Fig. 2 (a), beam divergence module be port be the optical fiber of naked port, the light beam of this module does not carries out shaping, and light beam of its output increases with distance and gradually dissipates, and irradiating the hot spot after hot spot and light beam assemble shaping has larger difference.
Animal auditory test module is as shown in Figure 3, including a testing cassete and an Auditory eletrophysiology measuring instrument, tested animal auditory tissue fixing after holding anesthesia in testing cassete, light beam is assembled the laser facula of Shaping Module output and is irradiated tested animal cochlea corresponding phonosensitive position in testing cassete (as cochlea round window membrane, the end turn or transfer hair cell or spiral ganglion), and measures its auditory response by Auditory eletrophysiology measuring instrument.Described auditory response can be cochlea Compound action potential (CAP), it is also possible to be ABR (ABR) and inferior colliculus neuron elementary reaction.
Data processing module: the auditory response signal that responsible process collects, processes through Auditory eletrophysiology measuring instrument, record experiment curv or data, computer of restoring, in order to analyze contrast.Described Auditory eletrophysiology measuring instrument is the various electrophysiologicalmeasurements measurements instrument that can be used for measuring the auditory response index of animal or people, the ABR measuring instrument of such as American I ntelligent Hearing System company, the electrophysiologicalmeasurements measurements instrument etc. of Nicolet company of the U.S..
Testing procedure and method:
1. the signal of telecommunication of exciting signal source output is in light source and driving module under electrical control circuit effect, converts the electrical signal to the light pulse signal of correspondence, in optical signal coupled feeding output optical fibre.Optical signal output arbitrarily can be regulated in pulse width, pulse recurrence rate, the multiple parameter of impulse amplitude by signal of telecommunication control.
2. testing with light power meter, through the light beam that the light path that pattern 1 and pattern 2 are different exports, under identical exciting signal source drives, the optical signal power of generation is without substantially loss, to verify the non-destructive that beam shaping processes.
3. gone out by surgical exposure that animal is to be measured listens irradiated tissue position
4, assign and check the measurement electrode of animal auditory electrophysiologicalmeasurements measurements instrument in testing cassete, it is ensured that firmly, effectively.
5. carry out light path pattern 1, the switching of pattern 2 in Lossless join mode, fix irradiating optical fiber with adjustable fixed support, keep stablizing of the distance between optical fiber light-emitting window and the illuminated position of aural tissue and hot spot.
6. set signal source and light source parameters, implement optical signal and irradiate
7. opening auditory response surveying record instrument, record measured waveform also preserves
8., under the conditions of each group of pumping signal and different range finding, measure the auditory response curve under pattern 1 and pattern 2 successively, and data are analyzed, just can draw the difference of the forward and backward optical signal parameters inducing auditory response of beam shaping.
Test result:
Compared with pattern 2, the laser beam delivery efficiency after pattern 1 shaping is higher, and facula area is more concentrated, and the laser power threshold needed for exciting animal auditory reaction is lower；Meanwhile, under same luminous power, the operating distance of the light beam after shaping and aural tissue can closely can far, easily facilitate command range, as shown in Figure 4.
Although the detailed description of the invention of the present invention is described by the above-mentioned accompanying drawing that combines; but not limiting the scope of the invention; one of ordinary skill in the art should be understood that; on the basis of technical scheme, those skilled in the art need not to pay various amendments or deformation that creative work can make still within protection scope of the present invention.
Claims (12)
1. the test system that the photo-induced sense of hearing is affected by a beam shaping, it is characterised in that: include the exciting signal source being sequentially connected, light source and drive module, Transmission Fibers, mode switch module, animal auditory test module and data processing module；
The optical signal that the animal auditory tissue that Transmission Fibers is transmitted by described mode switch module can identify flows to light beam and assembles Shaping Module or beam divergence module, it is achieved divergent beams and the switching assembled between light beam；
Described light beam is assembled the output illumination of Shaping Module or beam divergence module and is penetrated animal auditory tissue relevant position, uses animal auditory test module to test animal auditory and is organized in the auditory response signal of induction under gathering light beam and divergent beams；
The auditory response signal recorded is transferred to data processing module by described animal auditory test module；
Described data processing module is responsible for processing the auditory response signal collected, com-parison and analysis divergent beams and the difference of gathering optical beam induced auditory response.
Test system the most as claimed in claim 1, it is characterised in that: described exciting signal source is for modulated light source and drives module to produce the optical signal that can activate animal auditory tissue.
Test system the most as claimed in claim 1, it is characterized in that: described exciting signal source is the signal generator of the output parameter adjustable excitation signal of telecommunication, or sound is divided frequency range by the logarithmic scale meeting human hearing characteristic, by being converted to the Sound Processor Unit of the signal of telecommunication of the frequency range passage corresponding with each frequency range after processing.
Test system the most as claimed in claim 1, it is characterised in that: described light source and driving module are for producing the LED light source of optical signal, continuous or pulse laser.
Test system the most as claimed in claim 1, it is characterised in that: described mode switch module, realize Transmission Fibers by an exchanging structure and assemble the mutual switching between Shaping Module and beam divergence module at light beam.
Test system the most as claimed in claim 1, it is characterised in that: described mode switch module, the mode that the optical fiber pigtail of employing Transmission Fibers and light beam gathering Shaping Module or beam divergence module is directly fused realizes mutually switching.
Test system the most as claimed in claim 1, it is characterised in that: described light beam assembles Shaping Module, and including a naked fiber port, the signal output part at naked fiber port is provided with an optical shaping element；By optical shaping element, it is the light beam that collimation is good, the angle of divergence is little by beam shaping bigger for the angle of divergence.
Test system the most as claimed in claim 1, it is characterised in that: described beam divergence module is that port does not does any process, directly exports the naked fiber port of optical signal.
Test system the most as claimed in claim 1, it is characterised in that: described animal auditory test module, including a testing cassete and an Auditory eletrophysiology measuring instrument, tested animal auditory tissue fixing after holding anesthesia in described testing cassete；The cochlea corresponding phonosensitive position of described tested animal auditory tissue produces corresponding auditory response under different optical signals irradiate, and measures its auditory response by Auditory eletrophysiology measuring instrument.
Test system the most as claimed in claim 1, it is characterised in that: described light beam assembles Shaping Module and beam divergence module is arranged on an adjustable support for the accurately three-dimensional coordinate of regulation output beam.
The test system that the photo-induced sense of hearing is affected by 11. beam shapings as claimed in claim 9, it is characterized in that: described data processing module is responsible for processing the auditory response signal collected, process through Auditory eletrophysiology measuring instrument, record experiment curv or data, computer analysis of restoring contrasts, and obtains divergent beams and assembles the difference that light beam can induce the optical signal parameters of auditory response.
The method that the 12. test systems utilizing beam shaping as claimed in claim 9 to affect the photo-induced sense of hearing are tested, it is characterised in that:
After the signal of telecommunication of step 1. exciting signal source output is converted into the light pulse signal of correspondence, send in Transmission Fibers, test the light beam assembling the Shaping Module light path output different with beam divergence module through light beam simultaneously；
Step 2. makes the animal auditory irradiated tissue position in described animal auditory test module cruelly spill；
Step 3.
Assign and check the measurement electrode of sense of hearing electrophysiologicalmeasurements measurements instrument in testing cassete；
Step 4.
Carry out light path light beam and assemble Shaping Module and the switching of beam divergence module, keep stablizing of the distance between optical fiber light-emitting window and the illuminated position of aural tissue and hot spot；
Step 5. sets exciting signal source and light source and drives the parameter of module, implements optical signal and irradiates；
Step 6. opens Auditory eletrophysiology measuring instrument, and record measured waveform also preserves；
Step 7.
Under the conditions of each group of pumping signal and different range finding, measure light beam successively and assemble the auditory response curve under Shaping Module and beam divergence module, and data are analyzed,
Obtain divergent beams and assemble the difference that light beam can induce the optical signal parameters of auditory response.
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| CN103405291A (en) * | 2013-08-23 | 2013-11-27 | 重庆大学 | Transmission type multi-channel near-infrared light pulse cochlear nerve stimulation device |
| CN204445900U (en) * | 2015-01-08 | 2015-07-08 | 山东大学 | The test macro that a kind of beam shaping affects photo-induced audition |
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| JP3632194B2 (en) * | 2002-07-15 | 2005-03-23 | 石川 祐子 | Transducer for detecting acoustic and non-acoustic ossicular muscle activity |
| WO2009157825A1 (en) * | 2008-06-24 | 2009-12-30 | Atos Medical Ab | A method and device for diagnosing ear conditions |
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| CN102871797A (en) * | 2012-10-17 | 2013-01-16 | 山东大学 | Animal auditory measurement system and method based on optical fiber array laser sound effect |
| CN103405291A (en) * | 2013-08-23 | 2013-11-27 | 重庆大学 | Transmission type multi-channel near-infrared light pulse cochlear nerve stimulation device |
| CN204445900U (en) * | 2015-01-08 | 2015-07-08 | 山东大学 | The test macro that a kind of beam shaping affects photo-induced audition |
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