CN104596819B - A kind of lapping device for biological tissue - Google Patents
A kind of lapping device for biological tissue Download PDFInfo
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- CN104596819B CN104596819B CN201510026287.XA CN201510026287A CN104596819B CN 104596819 B CN104596819 B CN 104596819B CN 201510026287 A CN201510026287 A CN 201510026287A CN 104596819 B CN104596819 B CN 104596819B
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- base
- ball
- mill chamber
- upper lid
- grinding table
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Abstract
The invention discloses a kind of lapping device for biological tissue, including a grinding table with mechanical gear, grinding table is provided with a dismembyator, the dismembyator includes the equal base of a pair of shape sizes and upper lid, submounts are provided with regularly arranged multiple recessed mill chamber, semicircle ball-and-socket or semiellipse ball-and-socket are shaped as, a circular abrading-ball in each mill chamber, is respectively provided with；Upper face of covering is provided with quantity and base mill chamber quantity identical cavity, and position distribution is also adapted with base mill chamber, when upper lid turns over to be harmonious with base, its each cavity each mill chamber corresponding with base is mutually closed, form multiple spheroidals or ellipsoid confined space, biological tissue and abrading-ball are wrapped in interior, after base after being harmonious is fixed with upper lid fixture, base is connected with above grinding table by a slide unit, and upper lid is then connected with the actuating device in mechanical gear by a toggle；The drawer for placing ice chest is provided with grinding table below dismembyator.
Description
Technical field
The present invention relates in a kind of molecular biology to animal specimen (heart, liver, lung, muscle, intestinal, fur, bone etc.),
Plant sample (Oryza sativa L., Semen Maydiss, Semen Tritici aestivi, bean or pea, Semen arachidis hypogaeae etc.) is ground, and makes tissue homogenate, for RNA, DNA or protein extraction
A kind of biological tissue's lapping device..
Background technology
Currently, biosiss are recognized on molecular level, have become the Main way of modern biology development, postgraduate
Thing macromole, first has to obtain the highly purified and target substance with biological activity.The preparation work of biomacromolecule is related to
The each side such as physics, chemistry and biology surface technology, furthermore, it is desirable to the flow process of a science.Microorganism, plant and animal all can conducts
Prepare the raw material of biomacromolecule, selected material Main Basiss experiment purpose is determining.For conventional biological tissue's sample
This preparation, major part all uses homogenizer, ultrasound wave and electric bead grinding type grinder, and this is several.Homogenizer is that comparison is original
A kind of homogenization apparatus, although structure is simple, operate and be difficult to grasp balance, and, it is easily damaged；Ultrasound wave breaks
Broken applicable surface is little；Homogenization apparatus Ginding process is a further disadvantage is that every time the grinding used time is long, sample size is single.And electric bead
Though each sample size of mill formula dismembyator is more, noise is big, and the structure of its internal tissue fixator has many deficiencies, one
It is that tissue fixed mount is thin, the mill pearl in centrifuge tube easily smashes centrifuge tube；Two is that centrifuge tube is directly connected with air, centrifuge tube
The heat of generation can not be absorbed in time, reduce extraction effect；Three is that cover portion lacks buffer layer, is easily slipped.
The content of the invention
The drawbacks of present invention is for existing for several devices of background technology, there is provided a kind of simple and direct, easily and fast and can be completely
Biological tissue's lapping device that many groups of foot, multisample are carried out simultaneously.
To reach object above, the present invention is adopted the following technical scheme that and is achieved：
A kind of lapping device for biological tissue, including a grinding table with mechanical gear, set on grinding table
There is a dismembyator, it is characterised in that the dismembyator includes the equal base of a pair of shape sizes and upper lid, submounts set
The multiple recessed mill chamber of regular arrangement, is shaped as semicircle ball-and-socket or semiellipse ball-and-socket, and a circle is respectively provided with each mill chamber
Shape abrading-ball；The upper face of covering is provided with quantity and base mill chamber quantity identical cavity, and position distribution also with base mill chamber phase
Adapt to, when upper lid turns over to be harmonious with base, its each cavity each mill chamber corresponding with base is mutually closed, and forms multiple balls
Shape or ellipsoid confined space, biological tissue and abrading-ball are wrapped in, after the base after being harmonious is fixed with upper lid fixture, base
It is connected with above grinding table by a slide unit, upper lid is then by a toggle and the biography in mechanical gear
Dynamic device is connected；The drawer for placing ice chest is provided with grinding table below the dismembyator.
In such scheme, the actuating device in the mechanical gear includes one by motor-driven gear-shift mechanism,
The gear-shift mechanism connects a wheel disc above mechanical gear by a vertical power transmission shaft, and crank connecting link is set on wheel disc
Circular motion by toggle, is converted to interlinking lever end under the driving of vertical power transmission shaft by connection dismembyator, wheel disc
Linear motion, drive dismembyator it is laterally reciprocating along grinding table.
The slide unit is matched with a dovetail groove below dismembyator base by a guide rail above grinding table
Constituted.
The mill chamber, cavity interior walls are equipped with wear-resistant ceramic film；Circular abrading-ball is glass or ceramic grinding ball.
The advantage of apparatus of the present invention is, both single tissue can be ground, it is also possible to multisample, multigroup other group
Knit and be ground.And, make multisample, it is multigroup it is other be organized in process of lapping in be under identical conditions, reduce exopathogenic factor
Impact of the condition to experimental result；Meanwhile, meet and be ground tissue and as far as possible do not contact with metal, in case the infiltration of metal ion
Impact to experimental result.In addition, the present invention is cheap, easy to operate, also, saves for experimenter substantial amounts of
Time, and then, the loss of tissue antigen is reduced, is provided to improve the quality of experiment, meeting requirement of experiment, reduction experimentation cost
A kind of new approach.
Description of the drawings
Fig. 1 is apparatus of the present invention structural representation.
Fig. 2 is the understructure schematic diagram of swing tool in Fig. 1.
Fig. 3 is the superstructure schematic diagram of swing tool in Fig. 1.
In Fig. 1 to Fig. 3：1st, dismembyator；2nd, guide rail；3rd, grinding table；4th, drawer；5th, fixture；6th, motor；7th, change speed gear box；8、
Control panel；9th, power transmission shaft；10th, wheel disc；11st, base；12nd, mill chamber；13rd, abrading-ball；14th, upper lid；15th, cavity.
Specific embodiment
With reference to Fig. 1. a kind of lapping device for biological tissue, including a grinding table 3, it is provided with its left-half
Electric device (motor 6 and change speed gear box 7), before control panel 8 is installed, control to grind work by electronic control circuit
Time, speed.Change speed gear box 7 connects wheel disc 10 by a vertical power transmission shaft 9, sets crank connecting link connection positioned at grinding on wheel disc
A dismembyator 1 above platform right half part, the dismembyator are arranged below dovetail groove (Fig. 2) and are matched with the guide rail 2 on grinding table,
Circular motion by toggle, is converted to the linear motion of interlinking lever end, band under the drive of power transmission shaft by wheel disc 10
Dynamic dismembyator makees bilateral reciprocation along guide rail.Drawer 4 is provided with grinding table below dismembyator, ice chest is provided with, is used for
Dismembyator is lowered the temperature and is maintained at one it is stable in a low temperature of (between 0 ° -4 °), the size of ice chest should cover dismembyator
The scope of motion, can conveniently change ice by drawer.
With reference to Fig. 2, Fig. 3, dismembyator includes the base 11 and upper lid 14 of the big metallic plate of an equity, and base is arranged below dovetail
Groove and grinding table guide rail, submounts are provided with regularly arranged multiple recessed mill chamber 12, and the present embodiment is 9, rehearsal
Into 3 × 3 square formation.Mill chamber inwall is provided with wear-resistant ceramic film (such as alumina ceramics or zirconium oxide porcelain), and mill chamber 12 is shaped as semicircle
Ball-and-socket or semiellipse ball-and-socket, can be separately added into different types of biological tissue in each mill chamber while being ground, in each mill chamber
A circular glass or ceramic grinding ball 13 (identical with ceramic membrane materials) are respectively provided with, for grinding to biological tissue in mill chamber
Crocus is broken.
Upper lid 14 is provided with quantity and base mill chamber quantity identical cavity 15 above, and position distribution also with base mill chamber phase
Adapt to, its inwall also is provided with the ceramic membrane of material identical with mill chamber inwall.It is when upper lid 14 turns over to be harmonious with base 11, each recessed
Chamber mill chamber closure corresponding to base, forms spheroidal or ellipsoid confined space, biological tissue and abrading-ball is wrapped in interior.After being harmonious
Base and upper lid before and after both sides with the fixation of fixture 5 after, by the dovetail groove below base and grinding table guide rail, by upper lid
Below 14, on front side of (), middle pitman shaft (being not drawn in Fig. 3) is connected with connecting rod free end in Fig. 1 above, starts motor 6, so that it may
Realization carries out high-efficient grinding to variety classes biological tissue in multiple mill chambers.
Claims (2)
1. a kind of lapping device for biological tissue, an including grinding table with mechanical gear, grinding table are provided with
One dismembyator, it is characterised in that the dismembyator includes the equal base of a pair of shape sizes and upper lid, submounts are provided with
Regularly arranged multiple recessed mill chamber, is shaped as semicircle ball-and-socket or semiellipse ball-and-socket, be respectively provided with each mill chamber one it is circular
Abrading-ball；The upper face of covering is provided with quantity and base mill chamber quantity identical cavity, and position distribution is also mutually fitted with base mill chamber
Should, when upper lid turns over to be harmonious with base, its each cavity each mill chamber corresponding with base is mutually closed, and forms multiple spheroidals
Or ellipsoid confined space, biological tissue and abrading-ball are wrapped in, after the base after being harmonious is fixed with upper lid fixture, base leads to
Cross a slide unit to be connected with above grinding table, upper lid is then by a toggle and the transmission in mechanical gear
Device is connected；The drawer for placing ice chest is provided with grinding table below the dismembyator.
2. the lapping device of biological tissue is used for as claimed in claim 1, it is characterised in that the mill chamber, cavity interior walls are equal
It is provided with wear-resistant ceramic film；The circular abrading-ball is glass or ceramic grinding ball.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510026287.XA CN104596819B (en) | 2015-01-19 | 2015-01-19 | A kind of lapping device for biological tissue |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510026287.XA CN104596819B (en) | 2015-01-19 | 2015-01-19 | A kind of lapping device for biological tissue |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104596819A CN104596819A (en) | 2015-05-06 |
| CN104596819B true CN104596819B (en) | 2017-04-05 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510026287.XA Expired - Fee Related CN104596819B (en) | 2015-01-19 | 2015-01-19 | A kind of lapping device for biological tissue |
Country Status (1)
| Country | Link |
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| CN (1) | CN104596819B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107058085A (en) * | 2017-03-09 | 2017-08-18 | 武汉赛维尔生物科技有限公司 | A kind of full-automatic tissue grinder instrument of high flux |
| CN107831031A (en) * | 2017-10-30 | 2018-03-23 | 四川行之智汇知识产权运营有限公司 | Central control lever drives sampler |
| CN107617955A (en) * | 2017-11-03 | 2018-01-23 | 安徽鸿凌机电仪表(集团)有限公司 | A kind of plastic processing grinder |
| CN112958248B (en) * | 2021-02-02 | 2022-08-02 | 云南中医药大学 | Grinder for molecular biology experiments |
| CN112973925B (en) * | 2021-05-10 | 2021-09-10 | 江西省药品检验检测研究院 | Protein extraction is with homogenate device and protein extraction system |
| CN113337381B (en) * | 2021-06-30 | 2022-09-30 | 成都导胜生物技术有限公司 | Automatic grinding device and application thereof in obtaining single cells |
| CN114392117A (en) * | 2022-01-19 | 2022-04-26 | 贵州中医药大学第一附属医院 | Massage device for patients with lumbar intervertebral disc protrusion |
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| CN101279434A (en) * | 2008-05-04 | 2008-10-08 | 浙江工业大学 | Double-disk rotation eccentric V shaped groove grinding miller |
| CN101650274A (en) * | 2009-08-31 | 2010-02-17 | 宁波新芝生物科技股份有限公司 | High pass tissue grinder and grinding method |
| CN201437215U (en) * | 2009-07-30 | 2010-04-14 | 深圳市翠绿首饰股份有限公司 | grinding machine |
| CN101890387A (en) * | 2009-05-20 | 2010-11-24 | 河南理工大学 | Roller grinder |
| CN202033241U (en) * | 2010-11-24 | 2011-11-09 | 清华大学 | Cam-driven biological sample freezing and grinding device |
| CN102240946A (en) * | 2011-06-15 | 2011-11-16 | 大连大友高技术陶瓷有限公司 | Ball grinder |
| CN102288462A (en) * | 2011-01-25 | 2011-12-21 | 向华 | High-throughput tissue grinder |
| CN202974692U (en) * | 2012-11-30 | 2013-06-05 | 安徽科技学院 | Clustered type plant foliage collecting and crushing device |
| CN203843663U (en) * | 2014-04-03 | 2014-09-24 | 辽宁石化职业技术学院 | Single-shaft grinding machine for quartz glass sheet |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120202715A1 (en) * | 2011-02-09 | 2012-08-09 | Santiago Partida-Sanchez | Tissue dissaggregator device and methods of using the same |
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2015
- 2015-01-19 CN CN201510026287.XA patent/CN104596819B/en not_active Expired - Fee Related
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101279434A (en) * | 2008-05-04 | 2008-10-08 | 浙江工业大学 | Double-disk rotation eccentric V shaped groove grinding miller |
| CN101890387A (en) * | 2009-05-20 | 2010-11-24 | 河南理工大学 | Roller grinder |
| CN201437215U (en) * | 2009-07-30 | 2010-04-14 | 深圳市翠绿首饰股份有限公司 | grinding machine |
| CN101650274A (en) * | 2009-08-31 | 2010-02-17 | 宁波新芝生物科技股份有限公司 | High pass tissue grinder and grinding method |
| CN202033241U (en) * | 2010-11-24 | 2011-11-09 | 清华大学 | Cam-driven biological sample freezing and grinding device |
| CN102288462A (en) * | 2011-01-25 | 2011-12-21 | 向华 | High-throughput tissue grinder |
| CN102240946A (en) * | 2011-06-15 | 2011-11-16 | 大连大友高技术陶瓷有限公司 | Ball grinder |
| CN202974692U (en) * | 2012-11-30 | 2013-06-05 | 安徽科技学院 | Clustered type plant foliage collecting and crushing device |
| CN203843663U (en) * | 2014-04-03 | 2014-09-24 | 辽宁石化职业技术学院 | Single-shaft grinding machine for quartz glass sheet |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104596819A (en) | 2015-05-06 |
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