CN104592073A - 一类含烷氧苯的n-金刚烷酰胺类化合物、用途 - Google Patents
一类含烷氧苯的n-金刚烷酰胺类化合物、用途 Download PDFInfo
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- CN104592073A CN104592073A CN201510076142.0A CN201510076142A CN104592073A CN 104592073 A CN104592073 A CN 104592073A CN 201510076142 A CN201510076142 A CN 201510076142A CN 104592073 A CN104592073 A CN 104592073A
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- compound
- glucose
- glucokinase
- diabetes
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化合物 | EC50(nM) |
参比化合物D-1 | 25.8 |
化合物I-1 | 10.2 |
化合物I-2 | 13.1 |
化合物 | S0.5(mM) |
参比化合物D-1 | 3.6 |
化合物I | 2.2 |
化合物2 | 2.9 |
Claims (4)
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CN104592073A true CN104592073A (zh) | 2015-05-06 |
CN104592073B CN104592073B (zh) | 2016-03-30 |
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Citations (6)
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EP1496052A1 (en) * | 2002-03-26 | 2005-01-12 | Banyu Pharmaceutical Co., Ltd. | Novel aminobenzamide derivative |
EP1532980A1 (en) * | 2003-11-24 | 2005-05-25 | Novo Nordisk A/S | N-heteroaryl indole carboxamides and analogues thereof, for use as glucokinase activators in the treatment of diabetes |
CN101218236A (zh) * | 2005-07-09 | 2008-07-09 | 阿斯利康(瑞典)有限公司 | 作为治疗2型糖尿病的葡萄糖激酶调节剂的2-杂环基氧基苯甲酰基氨基杂环化合物 |
CN101273048A (zh) * | 2005-09-30 | 2008-09-24 | 诺瓦提斯公司 | 作为葡萄糖激酶激活剂用于治疗2型糖尿病的磺酰胺衍生物 |
CN101282966A (zh) * | 2005-08-09 | 2008-10-08 | 阿斯利康(瑞典)有限公司 | 用于治疗糖尿病的杂芳基氨基甲酰基苯衍生物 |
CN101233128B (zh) * | 2005-05-27 | 2011-08-10 | 阿斯利康(瑞典)有限公司 | 在糖尿病治疗中用作glk激活剂的杂芳基苯甲酰胺衍生物 |
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- 2015-02-12 CN CN201510076142.0A patent/CN104592073B/zh active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1496052A1 (en) * | 2002-03-26 | 2005-01-12 | Banyu Pharmaceutical Co., Ltd. | Novel aminobenzamide derivative |
EP1532980A1 (en) * | 2003-11-24 | 2005-05-25 | Novo Nordisk A/S | N-heteroaryl indole carboxamides and analogues thereof, for use as glucokinase activators in the treatment of diabetes |
CN101233128B (zh) * | 2005-05-27 | 2011-08-10 | 阿斯利康(瑞典)有限公司 | 在糖尿病治疗中用作glk激活剂的杂芳基苯甲酰胺衍生物 |
CN101218236A (zh) * | 2005-07-09 | 2008-07-09 | 阿斯利康(瑞典)有限公司 | 作为治疗2型糖尿病的葡萄糖激酶调节剂的2-杂环基氧基苯甲酰基氨基杂环化合物 |
CN101282966A (zh) * | 2005-08-09 | 2008-10-08 | 阿斯利康(瑞典)有限公司 | 用于治疗糖尿病的杂芳基氨基甲酰基苯衍生物 |
CN101273048A (zh) * | 2005-09-30 | 2008-09-24 | 诺瓦提斯公司 | 作为葡萄糖激酶激活剂用于治疗2型糖尿病的磺酰胺衍生物 |
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Denomination of invention: Alkoxy benzene-contained N-adamantane amide compound and application thereof Effective date of registration: 20170816 Granted publication date: 20160330 Pledgee: Guangdong Nanhai Rural Commercial Bank branch branch of Limited by Share Ltd Pledgor: FOSHAN SAIWEISI PHARMACEUTICAL TECHNOLOGY CO., LTD. Registration number: 2017990000756 |
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Effective date of registration: 20191028 Address after: 221399 north side of Qingnian East Road, Yunhe Town, Pizhou City, Xuzhou City, Jiangsu Province Patentee after: Pizhou Runhong Industry Co., Ltd. Address before: Chancheng district has 528000 Taiwan public in Guangdong province Foshan City No. 32 first floor 1636, shop No. 1637 Patentee before: FOSHAN SAIWEISI PHARMACEUTICAL TECHNOLOGY CO., LTD. |