CN104587415A - Heat clearing and diuresis promoting preparation for patients with cirrhosis and preparation method - Google Patents
Heat clearing and diuresis promoting preparation for patients with cirrhosis and preparation method Download PDFInfo
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Abstract
The invention discloses a heat clearing and diuresis promoting preparation for patients with cirrhosis, which is prepared from the following active pharmaceutical ingredients in part by weight: plantago 8-14 parts of semen plantaginis, 9-18 parts of faeces trogopterori, 6-13 parts of fortunellae hindsii, 8-12 parts of fructus nitrariae sibiricae, 12-21 parts of fructus lycii, 6-13 parts of radix paeoniae alba, 9-15 parts of radix curcumae, 10-15 parts of fructus corni, 7-18 parts of fructus schisandrae, 9-16 parts of cortex cinnamomi, 12-17 parts of poria, 11-20 parts of radix ophiopogonis, 14-18 parts of poria pararadicis and 9-16 parts of rhizoma anemarrhenae. Excellent effects of the invention are also reflected in that the traditional properties and modern pharmacology of traditional Chinese medicines are combined organically, drugs are used to form the prescription so as to improve the therapeutic effect, the preparation is convenient to take, safe and free from side effects, the traditional Chinese medicine not only has the effects of clearing heat and promoting dieresis, eliminating carbuncles and stagnation, as well as soothing the liver and relieving depression, but also can enhance hepatic microcirculation and prevent hepatic fibrosis, and the preparation is an ideal drug for treating cirrhosis and has the effect of treating both the symptoms and the root causes.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of liver cirrhosis patient clearing away heat-damp and promoting diuresis preparation and preparation method.
Background technology
Liver cirrhosis is that the liver caused by a variety of causes is chronic, and progressive diffusivity changes.Be characterized in a kind of cause of disease or several causes of disease repeatedly, long-term damage hepatocyte, cause hepatocellular degeneration and necrosis.After hepatocellular degeneration necrosis widely, there is fibrous tissue diffusivity hypertrophy in connective tissue regeneration in liver.Liver cell regeneration in liver simultaneously, form regenerated nodule, normal hepatocytes leaflet structure and vascularization are destroyed, and form pseudolobuli.Through the period (several years is many decades even) that one is quite grown, liver deforms gradually, and quality is hardening, claims this physiological and pathological to change into liver cirrhosis clinically.In China, liver cirrhosis is more common, and great majority are posthepatitic cirrhosis, and small part is alcoholic cirrhosis and Cirrhosis In Schistosomiasis.Because liver cirrhosis is in early days through actively control, can reverse or no longer be in progress, but late period will have a strong impact on patients ' life quality, even threat to life, therefore the control of liver cirrhosis is extremely important.
Motherland's medical science is without the name of disease of liver cirrhosis, and liver cirrhosis, to lump etc. for main clinical manifestation under a little portions distending pain, jaundice, the side of body, according to clinical symptoms and sign, is belonged to the category that the traditional Chinese medical science it " long-pending disease ", " jaundice ", " hypochondriac pain " etc. are sick by Yin Qichang." Medical Treasures of the Golden Chamber aqueous vapor " cloud: " edema caused by disorder of the liver person, its abdomen is unable to turn aside, side of body lower abdominal pain." its many evil invasion and attack by epidemic disease caused by damp-heat pathogen poison or insobriety accumulate raw damp and hot, stops over and do not go, then add the factors such as feelings will is easypro, gradually cause liver,spleen,kidney functional disorder, qi-blood-body fluid is fought knot mutually, caused by the liver pulse stasis blocking.For primary disease, the people such as Liu Shunong think that the positive QI-insufficiency of liver, damp and hot heresy are taken advantage of a weak point, and stay and do not go, and cause blood unfavorable, venation block, send out as primary disease.
Application publication number CN 104116832 A(application number 201410261190.2) Chinese invention patent document disclose a kind of medicine for the treatment of liver cirrhosis, the weight proportion of its each raw material components is: Herba Tagetis Patulae 1-5, Flos Carthami 13-17, Herba Artemisiae Scopariae 8-12, Radix Rehmanniae 6-10, Radix abutili indici 6-10, Poria 4-8, Herba Patriniae 1-5, Cortex Querci Mongolicae 6-10, Fructus Crataegi 6-10, Fructus Gardeniae 4-8, Radix Salviae Miltiorrhizae 10-14, Oletum Trogopterori 13-17, Cortex Moutan 8-12, changes lignum Ormosiae henryi 13-17.Application publication number CN 102908558 A(application number 201210446607.3) Chinese invention patent document disclose a kind of Chinese medicine for the treatment of liver cirrhosis, be made up of the raw material of following parts by weight: Radix Salviae Miltiorrhizae 6-12 part, Radix Glycyrrhizae 4-10 part, Semen Lepidii (Semen Descurainiae) 3-9 part, Semen Phaseoli 9-15 part, Fructus Hordei Germinatus 9-15 part, Massa Medicata Fermentata 9-15 part, Herba Artemisiae Scopariae 9-15 part, Semen Euryales 10-20 part, Cortex Lycii 9-15 part, Herba Artemisiae Annuae 6-12 part, Herba Plantaginis 9-15 part, Radix Angelicae Dahuricae 3-9 part, Herba Equiseti Hiemalis 3-9 part, Fructus Forsythiae 6-12 part, Carapax Trionycis 9-15 part, Folium Callicarpae Formosanae 1-3 part.Application publication number CN 103386084 A(application number 201310303716.4) Chinese invention patent document disclose a kind of decoction for the treatment of liver cirrhosis, be made up of the material of following weight proportioning: Calculus Bovis 10-14 part, Radix Panacis Quinquefolii 3-6 part, Concha Ostreae 2-8 part, Ramulus Cinnamomi 3-10 part, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 5-8 part, Olibanum 3-5 part, Thallus Laminariae (Thallus Eckloniae) 2-7 part, Semen Alpiniae Katsumadai 4-8 part, Eupolyphaga Seu Steleophaga 2-8 part, Crinis Carbonisatus 2-8 part, Radix Angelicae Sinensis 3-8 part, Rhizoma Curcumae 4-10 part, Radix Paeoniae Rubra 6-10 part and water 140-180 part.
The medicine of the existing treatment liver cirrhosis of existing market, be Western medicine mostly, Western medicine has certain side effect, often eats the system dysfunction that can cause in human body; Preferably adopt treatment by Chinese herbs, only have and treated by the method for Chinese medicine activating blood circulation to dissipate blood stasis, hard masses softening and resolving and raising autoimmunity, thoroughly could cure liver cirrhosis.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide one prepare simply, conveniently take, liver cirrhosis patient clearing away heat-damp and promoting diuresis preparation safely and effectively.This clearing away heat-damp and promoting diuresis preparation is evident in efficacy, without any side effects.
Technical scheme of the present invention is:
Liver cirrhosis patient clearing away heat-damp and promoting diuresis preparation, is prepared from by following bulk drugs, is weight portion: Semen Plantaginis 8-14; Oletum Trogopterori 9-18; Mountain Fructus Citri tangerinae 6-13; Herba Carlinae biebersteinii 8-12; Fructus Lycii 12-21; Radix Paeoniae Alba 6-13; Radix Curcumae 9-15; Fructus Corni 10-15; Fructus Schisandrae Chinensis 7-18; Cortex Cinnamomi 9-16; Poria 12-17; Radix Ophiopogonis 11-20; Poria cum Radix Pini 14-18; Rhizoma Anemarrhenae 9-16.
Preferred scheme is, Semen Plantaginis 10-12; Oletum Trogopterori 12-15; Mountain Fructus Citri tangerinae 8-11; Herba Carlinae biebersteinii 9-11; Fructus Lycii 15-18; Radix Paeoniae Alba 8-11; Radix Curcumae 11-13; Fructus Corni 11-14; Fructus Schisandrae Chinensis 10-15; Cortex Cinnamomi 12-13; Poria 13-16; Radix Ophiopogonis 14-17; Poria cum Radix Pini 15-17; Rhizoma Anemarrhenae 11-14.
Be more preferably, Semen Plantaginis 11; Oletum Trogopterori 13.5; Mountain Fructus Citri tangerinae 9.5; Herba Carlinae biebersteinii 10; Fructus Lycii 11.5; The Radix Paeoniae Alba 9.5; Radix Curcumae 12; Fructus Corni 12.5; Fructus Schisandrae Chinensis 12.5; Cortex Cinnamomi 12.5; Poria 14.5; Radix Ophiopogonis 15.5; Poria cum Radix Pini 16; The Rhizoma Anemarrhenae 12.5.
The preparation method of liver cirrhosis patient clearing away heat-damp and promoting diuresis decoction, step is as follows:
(1) Fructus Corni is except removal core, and slow fire is dried, and sieve is ash bits to the greatest extent, for subsequent use; Mel Jujubae is put into pot heat, then put into Herba Carlinae biebersteinii slow fire and stir evenly (Herba Carlinae biebersteinii: Mel Jujubae=10:3), be limited to mulse is dry, taking-up cools, for subsequent use;
(2) mountain Fructus Citri tangerinae is cleaned, and is used as medicine in pot, stirs with oil-sand, fry rear taking-up, cooling, for subsequent use; Semen Plantaginis is used as medicine in pot, micro-stir-fry, and spray into milk (Semen Plantaginis: milk=25:3), stir to all blotting, taking-up cools, for subsequent use;
(3) crude drug except Fructus Corni, Herba Carlinae biebersteinii, mountain Fructus Citri tangerinae and Semen Plantaginis is placed in Chinese medicinal pot, adopt water extraction heating extraction, first the clear water adding 6-9 times of raw material dose soaks (clear water preferably adding 7.5 times of raw material doses soaks), then the medical material after step (1) and step (2) process is added, intense fire boils and turns slow fire boiling three times, first time decocts 40-70 minute, second time and third time each extraction 25-45 minute (preferably second time and third time respectively extract 35 minutes), filter, collecting decoction, for subsequent use;
(4) continued to be evaporated to 2/3 of original liquid volume by above-mentioned gained decocting liquid, dry heat sterilization 30 minutes, encapsulation, to obtain final product.
The preparation method of above-mentioned liver cirrhosis patient clearing away heat-damp and promoting diuresis decoction, preferred scheme is, the time that in step (3), clear water soaks is 1.5-2.5 hour (time that preferred clear water soaks is 1.8-2.2 hour, and the time that the clear water be more preferably soaks is 2 hours).
The preparation method of above-mentioned liver cirrhosis patient clearing away heat-damp and promoting diuresis decoction, preferred scheme is, in step (3), first time decocts 50-60 minute (preferred first time decocts 55 minutes).
The preparation method of above-mentioned liver cirrhosis patient clearing away heat-damp and promoting diuresis decoction, preferred scheme is, in step (4), the temperature of dry heat sterilization is 88-102 DEG C (temperature of preferred dry heat sterilization is 92-98 DEG C, and the temperature of the dry heat sterilization be more preferably is 95 DEG C).
The preparation method of described pill is:
(1) Fructus Corni is cleaned, and adds saline solution and soaks 20-30 minute (add saline solution and soak 25 minutes), take out, dry, and then fries to aquamarine with oil-sand, takes out, shakeout, spreading for cooling, for subsequent use; Fructus Schisandrae Chinensis is cleaned, and drains, enters in steamer to steam 35-55 minute (preferably enter in steamer and steam 45 minutes), make its deliquescing, color blackening, takes out, and dries, for subsequent use;
(2) Semen Plantaginis is used as medicine in pot, and big fire is fried to black, sustainability, takes out cooling, smashs to pieces for subsequent use; It is for subsequent use that Cortex Cinnamomi smashs into fine powder to pieces; Radix Paeoniae Alba sheet is used as medicine pot, and slow fire is fried and taken out to micro-yellow, and cooling, grinds into powder for subsequent use; Oletum Trogopterori is put in medicine pot, and slow fire heats, and frying to there being stink smell to overflow, drenching into yellow wine, fry to micro-dry glossy time, taking-up, cools, smashs to pieces;
(3) crude drug after mountain Fructus Citri tangerinae, Herba Carlinae biebersteinii, Fructus Lycii, Radix Curcumae, Poria, dynamic, Poria cum Radix Pini and the Rhizoma Anemarrhenae and step (1) being processed together is placed in Chinese medicament extracting device, add the ethanol (preferably adding the ethanol that mass concentration is 80%) that mass concentration is 75-95%, heating and refluxing extraction twice, first time extracts 40-60 minute (preferably first time extracts 50 minutes), second time is extracted 25-45 minute (preferably second time is extracted 35 minutes), merge extracted twice liquid, filter, for subsequent use;
(4) by said extracted liquid concentrating under reduced pressure, reclaim ethanol, being concentrated into 80 DEG C of relative densities is the thick paste of 1.21-1.25, and add step (2) gained raw material medicated powder, mix homogeneously, making pellets by mixing medical powder with honey, obtains pill.
The preparation method of described thick paste agent is:
(1) put by Oletum Trogopterori in medicine pot, slow fire heats, and frying to there being stink smell to overflow, drenching into yellow wine, fry to micro-dry glossy time, taking-up, cools, smashs to pieces;
(2) the same Cortex Cinnamomi of Oletum Trogopterori step (1) processed, mountain Fructus Citri tangerinae, Herba Carlinae biebersteinii, Fructus Lycii, Fructus Corni, Fructus Schisandrae Chinensis and Poria cum Radix Pini are placed in Chinese medicinal pot, add water and do not have powder, slow fire boiling twice, each respectively decoction 34-46 minute (preferably each each decoction 40 minutes), filter, collecting decoction, concentrating under reduced pressure becomes paste, for subsequent use;
(3) Semen Plantaginis, the Radix Paeoniae Alba, Radix Curcumae, Poria, Radix Ophiopogonis and the Rhizoma Anemarrhenae are placed in Chinese medicament extracting device, add the ethanol extraction three times of 4-6 times of raw material dose, each respectively extraction 25-35 minute (preferably each each extraction 30 minutes), filter, merge extractive liquid, distilling under reduced pressure, reclaims ethanol, being concentrated into 75 DEG C of relative densities is the thick paste of 1.17-1.20, for subsequent use;
(4) by step (2) and the mixing of step (3) gained thick paste, dry heat sterilization, to obtain final product.
The preparation method of described tablet is:
(1) Radix Paeoniae Alba and Ramulus Cinnamomi water are mixed thoroughly (Radix Paeoniae Alba: Ramulus Cinnamomi water=1:0.5), are then placed in medicine pot, and slow fire is fried to water is dry, and taking-up cools, and pulverizes for subsequent use; Oletum Trogopterori is put in medicine pot, and slow fire heats, and frying to there being stink smell to overflow, drenching into yellow wine, fry to micro-dry glossy time, taking-up, cools, smashs to pieces, for subsequent use;
(2) Semen Plantaginis is used as medicine in pot, micro-stir-fry, and spray into milk (Semen Plantaginis: milk=25:3), stir to all blotting, taking-up cools, for subsequent use; Mountain Fructus Citri tangerinae is cleaned, and add clear water in the pot that is used as medicine, moderate heat boils, and taking-up is dried, and smashs to pieces for subsequent use;
(3) surplus stock medicine is placed in hot air drier, in 99 DEG C of dry 35-55 minutes (being preferable over 99 DEG C of dryings 45 minutes), taking out, be ground into fine powder, for subsequent use;
(4) by step (1)-step (3) gained raw material medicated powder mixing, cross 110-150 mesh sieve (preferred mistake 130 mesh sieve), add magnesium stearate and sucrose fine (raw material medicated powder: magnesium stearate: sucrose fine=6:1.3:1.1), stir, tabletted, to obtain final product.
Scientific formula of the present invention, preparation method is simple, taking convenience, Be very effective.In addition, excellent results of the present invention also shows:
1,traditional property of medicine and Chinese medicine modern pharmacology organically combine by the present invention, using drugs to form a prescription, promote curative effect; Taking convenience, safely, has no side effect;
2,this Chinese medicine not only has effect of clearing away heat-damp and promoting diuresis, eliminating carbuncle eliminating stagnation, dispersing the stagnated live-QI to relieve the stagnation of QI, can also enhance liver microcirculation, prevention hepatic fibrosis; Be the ideal medicament for the treatment of liver cirrhosis, there is effect for the treatment of both the principal and secondary aspects of a disease.
3,medicine source of the present invention is easy to get, and medical material is with low cost, determined curative effect, has higher promotional value.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1liver cirrhosis patient clearing away heat-damp and promoting diuresis preparation, is prepared from by following bulk drugs, is weight portion (45g/ part): Semen Plantaginis 8 parts; Oletum Trogopterori 9 parts; Mountain Fructus Citri tangerinae 6 parts; Herba Carlinae biebersteinii 8 parts; Fructus Lycii 12 parts; The Radix Paeoniae Alba 6 parts; Radix Curcumae 9 parts; Fructus Corni 10 parts; Fructus Schisandrae Chinensis 7 parts; Cortex Cinnamomi 9 parts; 12 parts, Poria; Radix Ophiopogonis 11 parts; Poria cum Radix Pini 14 parts; The Rhizoma Anemarrhenae 9 parts.
The preparation method of liver cirrhosis patient clearing away heat-damp and promoting diuresis decoction is:
(1) Fructus Corni is except removal core, and slow fire is dried, and sieve is ash bits to the greatest extent, for subsequent use; Mel Jujubae is put into pot heat, then put into Herba Carlinae biebersteinii slow fire and stir evenly (Herba Carlinae biebersteinii: Mel Jujubae=10:3), be limited to mulse is dry, taking-up cools, for subsequent use;
(2) mountain Fructus Citri tangerinae is cleaned, and is used as medicine in pot, stirs with oil-sand, fry rear taking-up, cooling, for subsequent use; Semen Plantaginis is used as medicine in pot, micro-stir-fry, and spray into milk (Semen Plantaginis: milk=25:3), stir to all blotting, taking-up cools, for subsequent use;
(3) crude drug except Fructus Corni, Herba Carlinae biebersteinii, mountain Fructus Citri tangerinae and Semen Plantaginis is placed in Chinese medicinal pot, adopt water extraction heating extraction, first the clear water adding 6 times of raw material doses soaks 1.5 hours, then add the medical material after step (1) and step (2) process, intense fire boils and turns slow fire boiling three times, and first time decocts 40 minutes, second time and third time respectively extract 25 minutes, filter, collecting decoction, for subsequent use;
(4) above-mentioned gained decocting liquid is continued be evaporated to 2/3,88 DEG C of dry heat sterilizations 30 minutes of original liquid volume, encapsulation, to obtain final product.
The instructions of taking of decoction of the present invention is: twice daily, each 150mL, warmly takes, 30 days courses for the treatment of.
Model case: king XX, man, 52 years old, people from Tai'an.Patient is to our hospital on October 17th, 2012.There is weak, abdominal distention symptom without obvious inducement before five months in patient, takes " yeast tablet " treatment voluntarily, to no effect, and non-systematic treating always.Before 1 week, patient starts exacerbation of symptoms, and companion's stomachache is generated heat, appetite is poor, has a strong impact on work and life.Come my institute after being introduced and check treatment.Check: patient's enlarged abdomen distension, blue veins exposes, and xerostomia is vexed, has insomnia, oliguria, the few Tianjin of deep red tongue, stringy and thready pulse.Liver function grade: ALT 62U/L, AST 85 U/L.Ascites checks: outward appearance is yellow slightly muddy.Be diagnosed as liver cirrhosis, traditional Chinese medical science differential diagnosis of diseases liver-depression and spleen-insufficiency type.
Take the present embodiment gained liver cirrhosis patient clearing away heat-damp and promoting diuresis decoction, instructions of taking: twice daily, each 150mL, warmly to take, 30 days courses for the treatment of.After taking two courses for the treatment of, patients symptomatic and sign obviously alleviate, and partial symptoms disappears completely, and liver function is obviously recovered; Continue to take two courses for the treatment of, patients symptomatic and sign all disappear, and all recoveries of liver function are normal, and patient's self-induction is fully recovered.Pay a return visit after three months, in order, nothing recurs patient body.
embodiment 2liver cirrhosis patient clearing away heat-damp and promoting diuresis preparation, is prepared from by following bulk drugs, is weight portion (25g/ part): Semen Plantaginis 14 parts; Oletum Trogopterori 18 parts; Mountain Fructus Citri tangerinae 13 parts; Herba Carlinae biebersteinii 12 parts; Fructus Lycii 21 parts; The Radix Paeoniae Alba 13 parts; Radix Curcumae 15 parts; Fructus Corni 15 parts; Fructus Schisandrae Chinensis 18 parts; Cortex Cinnamomi 16 parts; 17 parts, Poria; Radix Ophiopogonis 20 parts; Poria cum Radix Pini 18 parts; The Rhizoma Anemarrhenae 16 parts.
The preparation method of liver cirrhosis patient clearing away heat-damp and promoting diuresis pill is:
(1) Fructus Corni is cleaned, and adds saline solution and soaks 25 minutes, takes out, dries, and then fries to aquamarine with oil-sand, takes out, shakeout, spreading for cooling, for subsequent use; Fructus Schisandrae Chinensis is cleaned, and drains, enters in steamer and steam 45 minutes, make its deliquescing, color blackening, takes out, and dries, for subsequent use;
(2) Semen Plantaginis is used as medicine in pot, and big fire is fried to black, sustainability, takes out cooling, smashs to pieces for subsequent use; It is for subsequent use that Cortex Cinnamomi smashs into fine powder to pieces; Radix Paeoniae Alba sheet is used as medicine pot, and slow fire is fried and taken out to micro-yellow, and cooling, grinds into powder for subsequent use; Oletum Trogopterori is put in medicine pot, and slow fire heats, and frying to there being stink smell to overflow, drenching into yellow wine, fry to micro-dry glossy time, taking-up, cools, smashs to pieces;
(3) crude drug after mountain Fructus Citri tangerinae, Herba Carlinae biebersteinii, Fructus Lycii, Radix Curcumae, Poria, dynamic, Poria cum Radix Pini and the Rhizoma Anemarrhenae and step (1) being processed together is placed in Chinese medicament extracting device, add the ethanol that mass concentration is 80%, heating and refluxing extraction twice, first time extracts 50 minutes, second time is extracted 35 minutes, merge extracted twice liquid, filter, for subsequent use;
(4) by said extracted liquid concentrating under reduced pressure, reclaim ethanol, being concentrated into 80 DEG C of relative densities is the thick paste of 1.21-1.25, and add step (2) gained raw material medicated powder, mix homogeneously, making pellets by mixing medical powder with honey, obtains pill.
The instructions of taking of pill of the present invention is: every day three times, each 5-7 ball, and warm water is taken after mixing it with water, 30 days courses for the treatment of.
Model case: Tan XX, female, 39 years old, Dongying people.Patient is to our hospital in December in 2012 9 days.There is swollen abdomen in October, 2012, feel sick in patient, does not significantly take a turn for the better in local county hospital, comes my institute after being introduced and check treatment.Symptom: when being admitted to hospital patient's hepatalgia obviously, face and yellow, the weak all over power of eyes, anorexia, become thin, abdominal tympanites, oliguria, whole body xanthochromia.Check: liver function AST/ALT:104/60U/L, TBIL/DBIL:311.7/196.9umol/L, TP61g/L, ALB19g/L, A/G0.45g/L, PT22.1s, B ultrasonic Decompensated liver cirrhosis.Be diagnosed as liver cirrhosis.
Take the present embodiment gained liver cirrhosis patient clearing away heat-damp and promoting diuresis pill, instructions of taking: every day three times, each 5-7 ball, warm water is taken after mixing it with water, 30 days courses for the treatment of.After treating a course for the treatment of, patients symptomatic and sign obviously alleviate, and continue two courses for the treatment of of medication, sings and symptoms disappears completely, liver power recovery is normal, and continue medication and consolidated a course for the treatment of, patient's self-induction is fully recovered, pay a return visit after three months, without recurrence, patient body in order.
embodiment 3liver cirrhosis patient clearing away heat-damp and promoting diuresis preparation, is prepared from by following bulk drugs, is weight portion (40g/ part): Semen Plantaginis 10 parts; Oletum Trogopterori 12 parts; Mountain Fructus Citri tangerinae 8 parts; Herba Carlinae biebersteinii 9 parts; Fructus Lycii 15 parts; The Radix Paeoniae Alba 8 parts; Radix Curcumae 11 parts; Fructus Corni 11 parts; Fructus Schisandrae Chinensis 10 parts; Cortex Cinnamomi 12 parts; 13 parts, Poria; Radix Ophiopogonis 14 parts; Poria cum Radix Pini 15 parts; The Rhizoma Anemarrhenae 11 parts.
The preparation method of liver cirrhosis patient clearing away heat-damp and promoting diuresis thick paste agent is:
(1) put by Oletum Trogopterori in medicine pot, slow fire heats, and frying to there being stink smell to overflow, drenching into yellow wine, fry to micro-dry glossy time, taking-up, cools, smashs to pieces;
(2) the same Cortex Cinnamomi of Oletum Trogopterori step (1) processed, mountain Fructus Citri tangerinae, Herba Carlinae biebersteinii, Fructus Lycii, Fructus Corni, Fructus Schisandrae Chinensis and Poria cum Radix Pini are placed in Chinese medicinal pot, add water and do not have powder, slow fire boiling twice, each each decoction 40 minutes, filters, collecting decoction, concentrating under reduced pressure becomes paste, for subsequent use;
(3) Semen Plantaginis, the Radix Paeoniae Alba, Radix Curcumae, Poria, Radix Ophiopogonis and the Rhizoma Anemarrhenae are placed in Chinese medicament extracting device, add the ethanol extraction three times of 5 times of raw material doses, each each extraction 30 minutes, filter, merge extractive liquid, distilling under reduced pressure, reclaims ethanol, being concentrated into 75 DEG C of relative densities is the thick paste of 1.17-1.20, for subsequent use;
(4) by step (2) and the mixing of step (3) gained thick paste, dry heat sterilization, to obtain final product.
The instructions of taking of thick paste agent of the present invention is: every day three times, each 3-5 spoon, and warm water is taken after mixing it with water, 30 days courses for the treatment of.
Model case: Liu XX, man, 38 years old, people from Heze.Patient is to our hospital on April 11st, 2013.There is abdominal discomfort without obvious inducement in patient, abdominal distention before 3 months, and upper right abdomen is obvious, and has the trend increased the weight of.Once in community hospital's treatment, effect was undesirable, came my institute after being introduced and checked treatment.Symptom: patient's pot belly, Bilateral Symmetry, stomach wall is without skin lesion and cicatrix, and ventral breathing is weak, without varicosis and anomalous beat; Abdomen is soft; Inappetence, lean body mass, patient has the history of drinking history of 10 years, and drink every day more than 100g.Chemical examination abnormal liver function, liver enlargement, is diagnosed as liver cirrhosis.
Take the agent of the present embodiment gained liver cirrhosis patient clearing away heat-damp and promoting diuresis thick paste, instructions of taking: every day three times, each 3-5 spoon, warm water is taken after mixing it with water, 30 days courses for the treatment of.After taking two courses for the treatment of, patients symptomatic and sign obviously alleviate, and partial symptoms disappears completely, and liver function is obviously recovered; Continue to take two courses for the treatment of, patients symptomatic and sign all disappear, and all recoveries of liver function are normal, and patient's self-induction is fully recovered.Pay a return visit after three months, in order, nothing recurs patient body.
embodiment 4liver cirrhosis patient clearing away heat-damp and promoting diuresis preparation, is prepared from by following bulk drugs, is weight portion (30g/ part): Semen Plantaginis 12 parts; Oletum Trogopterori 15 parts; Mountain Fructus Citri tangerinae 11 parts; Herba Carlinae biebersteinii 11 parts; Fructus Lycii 18 parts; The Radix Paeoniae Alba 11 parts; Radix Curcumae 13 parts; Fructus Corni 14 parts; Fructus Schisandrae Chinensis 15 parts; Cortex Cinnamomi 13 parts; 16 parts, Poria; Radix Ophiopogonis 17 parts; Poria cum Radix Pini 17; The Rhizoma Anemarrhenae 14 parts.
The preparation method of liver cirrhosis patient clearing away heat-damp and promoting diuresis tablet is:
(1) Radix Paeoniae Alba and Ramulus Cinnamomi water are mixed thoroughly (Radix Paeoniae Alba: Ramulus Cinnamomi water=1:0.5), are then placed in medicine pot, and slow fire is fried to water is dry, and taking-up cools, and pulverizes for subsequent use; Oletum Trogopterori is put in medicine pot, and slow fire heats, and frying to there being stink smell to overflow, drenching into yellow wine, fry to micro-dry glossy time, taking-up, cools, smashs to pieces, for subsequent use;
(2) Semen Plantaginis is used as medicine in pot, micro-stir-fry, and spray into milk (Semen Plantaginis: milk=25:3), stir to all blotting, taking-up cools, for subsequent use; Mountain Fructus Citri tangerinae is cleaned, and add clear water in the pot that is used as medicine, moderate heat boils, and taking-up is dried, and smashs to pieces for subsequent use;
(3) surplus stock medicine is placed in hot air drier, in 99 DEG C of dryings 45 minutes, takes out, be ground into fine powder, for subsequent use;
(4) by step (1)-step (3) gained raw material medicated powder mixing, cross 130 mesh sieves, add magnesium stearate and sucrose fine (raw material medicated powder: magnesium stearate: sucrose fine=6:1.3:1.1), stir, tabletted, to obtain final product.
The preparation method of Tablets is: every day three times, and each 5, warm water is taken after mixing it with water, 30 days courses for the treatment of.
Model case: grandson XX, female, 45 years old, people from Zaozhuang.Patient is to our hospital on August 17th, 2013.Patient suffers from liver cirrhosis for many years, and attempted Western medicine and treatment by Chinese herbs, DeGrain, symptom slightly takes a turn for the better, but recurs again soon, and patient is deeply by ailing torment.Carried out my institute's treatment afterwards upon somebody's introduction.Check: patient's abdominal distention companion stomachache, heating, weak, sclera is slight xanthochromia, splenomegaly, two lower limbs edema, abnormal liver function, Abdominal B type ultrasonography prompts for fatty liver.
Take the present embodiment gained liver cirrhosis patient clearing away heat-damp and promoting diuresis tablet, instructions of taking: every day three times, each 5, warm water is taken after mixing it with water, 30 days courses for the treatment of.After treating two courses for the treatment of, patient is weak, abdominal distention symptom disappears completely, and two lower limbs edema disappears gradually, and after continuing two courses for the treatment of of medication, patient's liver power checking recovers normal, and two lower limbs edema disappears completely, and patient's self-induction is fully recovered.
embodiment 5liver cirrhosis patient clearing away heat-damp and promoting diuresis preparation, is prepared from by following bulk drugs, is weight portion (35g/ part): Semen Plantaginis 11 parts; Oletum Trogopterori 13.5 parts; Mountain Fructus Citri tangerinae 9.5 parts; Herba Carlinae biebersteinii 10 parts; Fructus Lycii 11.5 parts; The Radix Paeoniae Alba 9.5 parts; Radix Curcumae 12 parts; Fructus Corni 12.5 parts; Fructus Schisandrae Chinensis 12.5 parts; Cortex Cinnamomi 12.5 parts; 14.5 parts, Poria; Radix Ophiopogonis 15.5 parts; Poria cum Radix Pini 16 parts; The Rhizoma Anemarrhenae 12.5 parts.
The preparation method of liver cirrhosis patient heat clearing away profit decoction is:
(1) Fructus Corni is except removal core, and slow fire is dried, and sieve is ash bits to the greatest extent, for subsequent use; Mel Jujubae is put into pot heat, then put into Herba Carlinae biebersteinii slow fire and stir evenly (Herba Carlinae biebersteinii: Mel Jujubae=10:3), be limited to mulse is dry, taking-up cools, for subsequent use;
(2) mountain Fructus Citri tangerinae is cleaned, and is used as medicine in pot, stirs with oil-sand, fry rear taking-up, cooling, for subsequent use; Semen Plantaginis is used as medicine in pot, micro-stir-fry, and spray into milk (Semen Plantaginis: milk=25:3), stir to all blotting, taking-up cools, for subsequent use;
(3) crude drug except Fructus Corni, Herba Carlinae biebersteinii, mountain Fructus Citri tangerinae and Semen Plantaginis is placed in Chinese medicinal pot, adopt water extraction heating extraction, first the clear water adding 7.5 times of raw material doses soaks 2 hours, then add the medical material after step (1) and step (2) process, intense fire boils and turns slow fire boiling three times, and first time decocts 55 minutes, second time and third time respectively extract 35 minutes, filter, collecting decoction, for subsequent use;
(4) above-mentioned gained decocting liquid is continued be evaporated to 2/3,95 DEG C of dry heat sterilizations 30 minutes of original liquid volume, encapsulation, to obtain final product.
The instructions of taking of decoction of the present invention is: twice daily, each 150mL, warmly takes, 30 days courses for the treatment of.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Semen Plantaginis: base is former: be the seed of Plantaginaceae plant Herba Plantaginis or Plantago depressa Willd.Chemical analysis: containing volume phlegmatic temperament, aucubin, and containing plantenolic acid, choline, adenine, succinic acid, resin etc.Nature and flavor: sweet, cold.Gui Jing: enter kidney, urinary bladder channel.Function cures mainly: diuretic, heat clearing away, tomorrow, eliminates the phlegm.Control urinary obstruction, stranguria with turbid discharge, leukorrhagia, hematuria, heat-damp in summer dysentery, cough ant phlegm, arthralgia chiefly caused by damp pathogen, conjunctival congestion is hidden from view.
Oletum Trogopterori: base is former: be the dry feces of flying squirrel section animal trogopterus xanthipes and flying squirrel etc.Nature and flavor: bitter sweet, temperature.Gui Jing: enter liver, spleen channel.Function cures mainly: life promoting the circulation of blood pain relieving.Control all pains of trusted subordinate's vim and vigour, women's amenorrhea, postnatal blood stasis is had a pain; External treatment Serpentis, scorpion, centipete bite.Stir-fry is stopped blooding.Control metrorrhagia, menorrhagia, leucorrhea with bloody discharge is without cease.
Mountain Fructus Citri tangerinae: base is former: be the fruit of Rutaceae Fortunella plant mountain Fructus Citri tangerinae.Nature and flavor: pungent, sour, sweet, warm.Function cures mainly: promoting the circulation of QI to alleviate the stagnation in middle-JIAO, relieving cough and resolving phlegm.Cure mainly peratodynia, food stagnation distension, hernia, cough due to wind and cold, cold asthma.
Herba Carlinae biebersteinii: base is former: be the fruit of zygophyllaceae plant nitraria schoberi.Chemical analysis: aerial parts is containing biological hypertension alkali.Nature and flavor: sweet acid is micro-salty, temperature.Function cures mainly: strengthening the spleen and stomach, strengthening by means of tonics, regulating menstruation and activating blood.Control asthenic body, deficiency of both QI and blood, incoordination between the spleen and stomach, dyspepsia, menoxenia, waist abdomen pain.
Fructus Lycii: base is former: be the mature fruit of matrimony vine of solanaceae plant or lycium barbarum.Chemical analysis: containing carotene 3.39 milligrams of %, thiamine 0.23 milligram of %, riboflavin 0.33 milligram of %, nicotinic acid 1.7 milligrams of %, ascorbic acid 3 milligrams of % in Fructus Lycii.Still isolate cupreol, linoleic acid.Pharmacological action: 1. lipotropic effect; 2. choline-like effect is intended; Nature and flavor: sweet are flat.Gui Jing: enter liver, kidney channel.Function cures mainly: nourishing kidney, lung moistening, tonifying liver, improving eyesight.Control hepatic and renal YIN deficiency, soreness of the waist and knees, dizzy, dizzy, the many tear of blurred vision, cough due to consumptive disease, quenches one's thirst, seminal emission.
The Radix Paeoniae Alba: base is former: this product is the dry root of ranunculaceae plant Radix Paeoniae.Chemical analysis: root contains paeoniflorin, paeonol, paeoniflorin, benzoic acid about 1.07%, volatile oil, fatty oil, resin, tannin, sugar, starch, phlegmatic temperament, protein, cupreol and triterpenes.Nature and flavor: bitter, sour, are slightly cold.Gui Jing: return liver, spleen channel.Effect: suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.Cure mainly: dizzy for having a headache, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat.
Radix Curcumae: base is former: be the tuber of zingiberaceous plant Rhizoma Curcumae Longae, Radix Curcumae or Rhizoma Curcumae.Nature and flavor: arduous, cool.Gui Jing: enter the heart, lung, Liver Channel.Function cures mainly: promoting QI circulation for relieving depression, removing heat from blood removing blood stasis with potent drugs.Control all pains of breast abdomen side of body rib, lose the heart demented, calentura coma, spit blood, epistaxis, hematuria, stranguria with blood, women's vicarious menstruation, jaundice.
Fructus Corni: base is former: this product is the drying and ripening sarcocarp of Fructus Corni English section plant Fructus Corni.Chemical analysis: containing morroniside, 7-0-methyl morroniside, sweroside, loganin, Fructus Corni tannin 1,2,3 etc.Nature and flavor: sour, puckery, tepor.Gui Jing: return liver, kidney channel.Effect: liver and kidney tonifying, essence astringing and desertion stemming.Cure mainly: for vertigo and tinnitus, soreness of waist and knee joint, sun is passed out semen repeatly, enuresis frequent micturition, bleeding not during menses, and profuse sweating is collapsed, and interior-heat is quenched one's thirst.
Fructus Schisandrae Chinensis: base is former: this product is the dry mature fruit of magnoliaceae schisandra.Chemical analysis: containing schizandrin, deoxidation schizandrin, new son simply element, schisandrol, schizantherin etc.Pharmacological action: the vision of normal person and persons suffering from ocular disorders can be improved and broaden one's vision; Also there is good impact to audition, state the discriminative power that can improve skin receptor.Nature and flavor: sour, sweet, temperature.Gui Jing: return lung, the heart, kidney channel.Effect: restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.Cure mainly: for chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, and deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.
Cortex Cinnamomi: base is former: be dried bark and the branch skin of canella Cortex Cinnamomi.Chemical analysis: skin is containing volatile oil (title Oleum Cinnamomi) 1 ~ 2%, and main component is cinnamic aldehyde 75 ~ 90%, and containing a small amount of acetic acid Cortex cinnamomi japonici (Ramulus Cinnamomi) ester, phenylpropyl acetate etc.Pharmacological action: 1. to the effect of central nervous system: the cinnamic aldehyde contained in Cortex Cinnamomi is to the obvious sedation of mice Ke; 2. hypotensive effect, 3. prevents the effect of schistosomicide.Nature and flavor: Xin Gan, heat.Gui Jing: enter kidney, spleen, urinary bladder channel.Function cures mainly: complement sun, warming the spleen and stomach, removing accumulated cold, promoting blood circulation.Control decline of the fire from the gate of life, cold extremities faint pulse, YANG-depletion is collapsed, and stomachache is had loose bowels, colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea lump in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower.
Poria: base is former: this product is the dry sclerotia of On Polyporaceae Poria.Character: Poria spherical, oval in class, an oblate or irregular agglomerate, not of uniform size.Crust is thin and coarse, and sepia, to pitchy, has obvious shrinkage texture.Nature and flavor: sweet, light are flat.Gui Jing: GUIXIN, lung, spleen, kidney channel.Effect: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.Cure mainly: for edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.
Radix Ophiopogonis: source: this product is the dried root of liliaceous plant Radix Ophiopogonis (dwarf lilyturf).Character: this product is spindle, two ends are point slightly.Surface yellow-white or faint yellow, has thin longitudinal grin.Matter is pliable and tough, section yellow-white, and translucent, center pillar is tiny.Nature and flavor: sweet, micro-hardship, is slightly cold.Gui Jing: GUIXIN, lung, stomach warp.Function cures mainly: YIN nourishing and the production of body fluid promoting, and lung moistening clears away heart-fire.For dryness of the lung dry cough.Chronic consumptive disease is coughed, and Tianjin wound is thirsty, vexed insomnia, and interior-heat is quenched one's thirst, dryness of the intestine constipation; Pharyngeal diphtheria.
Poria cum Radix Pini: base is former: be the natural white portion entertaining Radix Pini massonianae (i.e. " Lignum Poria ") in the middle of Polyporaceae plant poria cocos sclerotium.Nature and flavor: sweet light are flat.Gui Jing: enter the heart, spleen channel.Function cures mainly: mind calming, calms the nerves, diuretic.Control palpitation with fear of having a guilty conscience, forgetful, insomnia, infantile convulsion, dysuria.Pharmacological action: sedation.
The Rhizoma Anemarrhenae: base is former: be the rhizome of the liliaceous plant Rhizoma Anemarrhenae.Chemical analysis: main containing Saponin.Rhizome is containing Total saponin about 6%, therefrom detect 6 kinds of Saponins, be called zhimusaponin A-I, A-II, A-III, A-IV, B-I and B-II, wherein zhimusaponin A-III is the disaccharidase glycoside that Sa Ersa ruscogenin and timobiose are combined into, and zhimusaponin A-I is Sa Ersa ruscogenin β-D-galactopyranosyl glucoside.Ruscogenin in Asphodeloides Bge Rhizome is Sa Ersa ruscogenin mainly, the content in dry root about 0.5%.Pharmacological action: 1. antibacterial action, 2. refrigeration function, 3. other effects.Nature and flavor: bitter, cold.Gui Jing: enter lung, stomach, kidney channel.Function cures mainly: nourishing YIN to lower pathogenic fire, moisturizes laxation.Control dysphoria with smothery sensation to quench one's thirst, hectic fever due to YIN-deficiency consumptive fever, cough due to lung-heat, constipation due to dry stool, dysuria.
test example 1the clinical practice of gained liver cirrhosis patient clearing away heat-damp and promoting diuresis preparation (embodiment 5) of the present invention:
1 data and method
1.1 physical data
Choose liver cirrhosis patient 346 that in July ,-2013 in March, 2011, my institute accepted for medical treatment example, wherein male 196 example, women 150 example, age 34-68 year, 44.5 ± 2.5 years old mean age.Diagnostic criteria during all patients all meet " liver cirrhosis combination of Chinese and Western medicine diagnosis and treatment project ".
1.2 diagnostic criteria
(1) tcm diagnosis standard: damp-heat accumulation type symptom: enlarged abdomen heavily fortified point is full, and gastral cavity belly stay is anxious, dysphoria with smothery sensation bitter taste, thirst but no desire to drink, hot urination, constipation or half congealed dirt, tongue tip side of red, yellowish fur or double greyish black, wiry and frequent pulse, or have appearance yellowing of the skin.
(2) scope or esophagus gulp down the visible esophagus fundus ventricularis varication of barium X ray examination; Chemical examination abnormal liver function or Serum hyaluronic acid increase;
(3) B super prompting liver echo obviously strengthens, uneven, luminous point is thick; Or liver surface owes smooth, uneven or indentation; Or portal vein diameter >=1.4cm; Or spleen increases, splenic vein diameter >=1.0cm; Ascites, companion's vena epigastrica anger is opened;
(4) CT shows liver outer rim nodositas protuberance, and fissure expands, caudal lobe/lobus dexter ratio >0.05, splenomegaly; Peritoneoscope or needle biopsy of liver are examined as liver cirrhosis;
1.3 Therapeutic Method
All patients are divided into treatment group and matched group at random, and two groups of patients, in sex, the state of an illness, the course of disease etc., through statistical procedures no significant difference (P > 0.05), have comparability.Wherein treatment group takes gained medicine of the present invention, observes three courses for the treatment of of treatment altogether.Matched group takes other drug (as conventional medicines such as FUFANG BIEJIA RUANGAN PIAN, gan fu le capsule, sweet wormwood herb and turtle shell sheets).
1.4 curative effect determinate standard
Clinical cure: clinical symptoms and sign all disappear, spleen bounces back, and ascites disappears, and liver function test result is normal; Effective: clinical cardinal symptom disappears or takes a turn for the better, and spleen bounces back to some extent, ascites and liver function recovery more than 50%; Effective: clinical symptoms and sign are slightly improved, and liver function recovery is less than 50%; Invalid: clinical symptoms and sign are improvement or sb.'s illness took a turn for the worse person.
1.5 therapeutic outcome
Result is as shown in table 1.
Table 1: the therapeutic outcome for the treatment of group and matched group liver cirrhosis patient
Therapeutic effect: clinical cure 149 example (69%), effective 43 examples (19.9%), effective 21 examples (9.7%), invalid 3 examples (1.4%), total effective rate 98.6%.Treatment group successful is better than matched group.
The present invention by Semen Plantaginis, Oletum Trogopterori, mountain Fructus Citri tangerinae, Herba Carlinae biebersteinii, Fructus Lycii, the Radix Paeoniae Alba, Radix Curcumae, Fructus Corni and Fructus Schisandrae Chinensis etc. totally 14 taste primary raw material medicines be prepared from.Fang Zhong, Semen Plantaginis has diuretic, heat clearing away, tomorrow, the effect of eliminating the phlegm; Herba Carlinae biebersteinii, the body resistance strengthening and constitution consolidating, benefiting QI and nourishing blood, tonification the five internal organs, enhancing human body immunity power; Cortex Cinnamomi, Fructus Schisandrae Chinensis, Fructus Corni liver and kidney tonifying, blood circulation promoting and blood stasis dispelling, enhance liver microcirculation; Radix Curcumae, the pain relieving of Radix Paeoniae Alba suppressing the hyperactive liver, clearing away heat-damp and promoting diuresis; Mountain Fructus Citri tangerinae promoting the circulation of QI to alleviate the stagnation in middle-JIAO, relieving cough and resolving phlegm.Poria promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.All medicine compatibilities, bring out the best in each other, play the body resistance strengthening and constitution consolidating altogether, clearing away heat-damp and promoting diuresis, blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, the merit of eliminating carbuncle eliminating stagnation.Treat three courses for the treatment of, treatment group total effective rate is 98.6%, and matched group total effective rate is only 77.7%.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. liver cirrhosis patient clearing away heat-damp and promoting diuresis preparation, is characterized in that, is prepared from by following bulk drugs, is weight portion: Semen Plantaginis 8-14; Oletum Trogopterori 9-18; Mountain Fructus Citri tangerinae 6-13; Herba Carlinae biebersteinii 8-12; Fructus Lycii 12-21; Radix Paeoniae Alba 6-13; Radix Curcumae 9-15; Fructus Corni 10-15; Fructus Schisandrae Chinensis 7-18; Cortex Cinnamomi 9-16; Poria 12-17; Radix Ophiopogonis 11-20; Poria cum Radix Pini 14-18; Rhizoma Anemarrhenae 9-16.
2. liver cirrhosis patient clearing away heat-damp and promoting diuresis preparation as claimed in claim 1, is characterized in that, be prepared from by following bulk drugs, be weight portion: Semen Plantaginis 10-12; Oletum Trogopterori 12-15; Mountain Fructus Citri tangerinae 8-11; Herba Carlinae biebersteinii 9-11; Fructus Lycii 15-18; Radix Paeoniae Alba 8-11; Radix Curcumae 11-13; Fructus Corni 11-14; Fructus Schisandrae Chinensis 10-15; Cortex Cinnamomi 12-13; Poria 13-16; Radix Ophiopogonis 14-17; Poria cum Radix Pini 15-17; Rhizoma Anemarrhenae 11-14.
3. liver cirrhosis patient clearing away heat-damp and promoting diuresis preparation as claimed in claim 1, is characterized in that, be prepared from by following bulk drugs, be weight portion: Semen Plantaginis 11; Oletum Trogopterori 13.5; Mountain Fructus Citri tangerinae 9.5; Herba Carlinae biebersteinii 10; Fructus Lycii 11.5; The Radix Paeoniae Alba 9.5; Radix Curcumae 12; Fructus Corni 12.5; Fructus Schisandrae Chinensis 12.5; Cortex Cinnamomi 12.5; Poria 14.5; Radix Ophiopogonis 15.5; Poria cum Radix Pini 16; The Rhizoma Anemarrhenae 12.5.
4. the liver cirrhosis patient clearing away heat-damp and promoting diuresis preparation as described in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable decoction, preparation method is as follows:
(1) Fructus Corni is except removal core, and slow fire is dried, and sieve is ash bits to the greatest extent, for subsequent use; Mel Jujubae is put into pot heat, then put into Herba Carlinae biebersteinii slow fire and stir evenly (Herba Carlinae biebersteinii: Mel Jujubae=10:3), be limited to mulse is dry, taking-up cools, for subsequent use;
(2) mountain Fructus Citri tangerinae is cleaned, and is used as medicine in pot, stirs with oil-sand, fry rear taking-up, cooling, for subsequent use; Semen Plantaginis is used as medicine in pot, micro-stir-fry, and spray into milk (Semen Plantaginis: milk=25:3), stir to all blotting, taking-up cools, for subsequent use;
(3) crude drug except Fructus Corni, Herba Carlinae biebersteinii, mountain Fructus Citri tangerinae and Semen Plantaginis is placed in Chinese medicinal pot, adopt water extraction heating extraction, first the clear water adding 6-9 times of raw material dose soaks (clear water preferably adding 7.5 times of raw material doses soaks), then the medical material after step (1) and step (2) process is added, intense fire boils and turns slow fire boiling three times, first time decocts 40-70 minute, second time and third time each extraction 25-45 minute (preferably second time and third time respectively extract 35 minutes), filter, collecting decoction, for subsequent use;
(4) continued to be evaporated to 2/3 of original liquid volume by above-mentioned gained decocting liquid, dry heat sterilization 30 minutes, encapsulation, to obtain final product.
5. liver cirrhosis patient clearing away heat-damp and promoting diuresis decoction according to claim 4 preparation method, it is characterized in that, the time that in step (3), clear water soaks is 1.5-2.5 hour (time that preferred clear water soaks is 1.8-2.2 hour, and the time that the clear water be more preferably soaks is 2 hours).
6. liver cirrhosis patient clearing away heat-damp and promoting diuresis decoction according to claim 4 preparation method, it is characterized in that, first time decocts 50-60 minute (preferred first time decocts 55 minutes) in step (3).
7. liver cirrhosis patient clearing away heat-damp and promoting diuresis decoction according to claim 4 preparation method, it is characterized in that, in step (4), the temperature of dry heat sterilization is 88-102 DEG C (temperature of preferred dry heat sterilization is 92-98 DEG C, and the temperature of the dry heat sterilization be more preferably is 95 DEG C).
8. the liver cirrhosis patient clearing away heat-damp and promoting diuresis preparation as described in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable pill, preparation method is as follows:
(1) Fructus Corni is cleaned, and adds saline solution and soaks 20-30 minute (add saline solution and soak 25 minutes), take out, dry, and then fries to aquamarine with oil-sand, takes out, shakeout, spreading for cooling, for subsequent use; Fructus Schisandrae Chinensis is cleaned, and drains, enters in steamer to steam 35-55 minute (preferably enter in steamer and steam 45 minutes), make its deliquescing, color blackening, takes out, and dries, for subsequent use;
(2) Semen Plantaginis is used as medicine in pot, and big fire is fried to black, sustainability, takes out cooling, smashs to pieces for subsequent use; It is for subsequent use that Cortex Cinnamomi smashs into fine powder to pieces; Radix Paeoniae Alba sheet is used as medicine pot, and slow fire is fried and taken out to micro-yellow, and cooling, grinds into powder for subsequent use; Oletum Trogopterori is put in medicine pot, and slow fire heats, and frying to there being stink smell to overflow, drenching into yellow wine, fry to micro-dry glossy time, taking-up, cools, smashs to pieces;
(3) crude drug after mountain Fructus Citri tangerinae, Herba Carlinae biebersteinii, Fructus Lycii, Radix Curcumae, Poria, dynamic, Poria cum Radix Pini and the Rhizoma Anemarrhenae and step (1) being processed together is placed in Chinese medicament extracting device, add the ethanol (preferably adding the ethanol that mass concentration is 80%) that mass concentration is 75-95%, heating and refluxing extraction twice, first time extracts 40-60 minute (preferably first time extracts 50 minutes), second time is extracted 25-45 minute (preferably second time is extracted 35 minutes), merge extracted twice liquid, filter, for subsequent use;
(4) by said extracted liquid concentrating under reduced pressure, reclaim ethanol, being concentrated into 80 DEG C of relative densities is the thick paste of 1.21-1.25, and add step (2) gained raw material medicated powder, mix homogeneously, making pellets by mixing medical powder with honey, obtains pill.
9. the liver cirrhosis patient clearing away heat-damp and promoting diuresis preparation as described in claim 1-3, is characterized in that, be made into pharmaceutically acceptable thick paste agent, preparation method is as follows:
(1) put by Oletum Trogopterori in medicine pot, slow fire heats, and frying to there being stink smell to overflow, drenching into yellow wine, fry to micro-dry glossy time, taking-up, cools, smashs to pieces;
(2) the same Cortex Cinnamomi of Oletum Trogopterori step (1) processed, mountain Fructus Citri tangerinae, Herba Carlinae biebersteinii, Fructus Lycii, Fructus Corni, Fructus Schisandrae Chinensis and Poria cum Radix Pini are placed in Chinese medicinal pot, add water and do not have powder, slow fire boiling twice, each respectively decoction 34-46 minute (preferably each each decoction 40 minutes), filter, collecting decoction, concentrating under reduced pressure becomes paste, for subsequent use;
(3) Semen Plantaginis, the Radix Paeoniae Alba, Radix Curcumae, Poria, Radix Ophiopogonis and the Rhizoma Anemarrhenae are placed in Chinese medicament extracting device, add the ethanol extraction three times of 4-6 times of raw material dose, each respectively extraction 25-35 minute (preferably each each extraction 30 minutes), filter, merge extractive liquid, distilling under reduced pressure, reclaims ethanol, being concentrated into 75 DEG C of relative densities is the thick paste of 1.17-1.20, for subsequent use;
(4) by step (2) and the mixing of step (3) gained thick paste, dry heat sterilization, to obtain final product.
10. the liver cirrhosis patient clearing away heat-damp and promoting diuresis preparation as described in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable tablet, preparation method is as follows:
(1) Radix Paeoniae Alba and Ramulus Cinnamomi water are mixed thoroughly (Radix Paeoniae Alba: Ramulus Cinnamomi water=1:0.5), are then placed in medicine pot, and slow fire is fried to water is dry, and taking-up cools, and pulverizes for subsequent use; Oletum Trogopterori is put in medicine pot, and slow fire heats, and frying to there being stink smell to overflow, drenching into yellow wine, fry to micro-dry glossy time, taking-up, cools, smashs to pieces, for subsequent use;
(2) Semen Plantaginis is used as medicine in pot, micro-stir-fry, and spray into milk (Semen Plantaginis: milk=25:3), stir to all blotting, taking-up cools, for subsequent use; Mountain Fructus Citri tangerinae is cleaned, and add clear water in the pot that is used as medicine, moderate heat boils, and taking-up is dried, and smashs to pieces for subsequent use;
(3) surplus stock medicine is placed in hot air drier, in 99 DEG C of dry 35-55 minutes (being preferable over 99 DEG C of dryings 45 minutes), taking out, be ground into fine powder, for subsequent use;
(4) by step (1)-step (3) gained raw material medicated powder mixing, cross 110-150 mesh sieve (preferred mistake 130 mesh sieve), add magnesium stearate and sucrose fine (raw material medicated powder: magnesium stearate: sucrose fine=6:1.3:1.1), stir, tabletted, to obtain final product.
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