CN104587155B - A kind of medicament for the treatment of uterine prolapse - Google Patents
A kind of medicament for the treatment of uterine prolapse Download PDFInfo
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- CN104587155B CN104587155B CN201510092468.2A CN201510092468A CN104587155B CN 104587155 B CN104587155 B CN 104587155B CN 201510092468 A CN201510092468 A CN 201510092468A CN 104587155 B CN104587155 B CN 104587155B
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Abstract
The present invention relates to a kind of medicament for the treatment of uterine prolapse, it is made up of the material of following weight portion: Radix Bauhiniae Hupehanae 10-20 part, Herba polygoni hydropiperis 10-20 part, Herba Lepisori Thunbergiani 5-15 part, Fructus pruni pubescentis 5-15 part, SEMEN ASTRAGALI COMPLANATI 5-15 part, Herba Artemisiae Selengensis 1-10 part, Radix Maesae Japonicae 5-15 part, Radix Polygoni Chinensis 5-15 part, Radix Glycyrrhizae 1-10 part, Herba Gnaphalii uliginosi 5-15 part, Herba hyperici attenuati 10-20 part, Radix seu Folium Tetracerae asiaticae 10-20 part, Herba Epilobii Himalayensis 10-20 part, Parmelia tinctorum Despr. 1-10 part, Cortex schizophragmatis integrifolii radicis 5-15 part, Pseudobulbus Pholidotae Chinensis 5-15 part, blue Jacob's ladder 20-30 part, Semen Nigellae 5-15 part.Medicament of the present invention can play the effect that invigorating middle warmer has tune, negative and positive are all mended, and few side effects, safe ready, treatment uterine prolapse good effect, gets that effect is fast, cure rate is high, and clinic is applied.
Description
Technical field
The present invention relates to field of medicaments, relate in particular to a kind of medicament for the treatment of uterine prolapse.
Background technology
Uterine prolapse refers to that uterus declines from normal position along vagina, and it is below horizontal that cervical orifice reaches ischial spine, and even uterus all emerges in beyond vaginal orifice.Primary disease is multiple to be born in work women excessive, weak and sickly, worn with age or to give birth to puerpera more, clinically main manifestations be the soreness of waist, abdominal part tenesmus, work and walking after symptom can increase the weight of, the related symptoms such as frequent micturition or dysuria, urine retention, urinary incontinence and leucorrhoea grow in quantity can be there is in even more serious person.Wherein III degree of prolapsus person deviates from outside vagina due to cervix uteri and palace body, deviates from part often friction, can cause infection and General Symptoms, bring very large misery to the live and work of ill women.
Modern medicine is thought, uterus mainly relies on the rest of pelvic floor tissue and each suporting ligament and maintains normal position, if Pelvic support structure damage, laxity of ligament, uterus loses support, then decline along vagina and cause uterine prolapse.Western medical treatment many employings pessulum or operative treatment, but the former operates inconvenience, need continue to wear, and the latter damages large and side effect is many.And the traditional Chinese medical science is mainly through determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, treating both the principal and secondary aspects of a disease, and have no side effect, compare doctor trained in Western medicine more safe and reliable.
Chinese medicine thinks that uterine prolapse belongs to " prolapse of the uterus " category, and also known as " born of the same parents fall ", its pathogenesis is deficiency of the spleen causing weakness of QI, sinking of QI of middle-JIAO, can not carry and taking the photograph; Or ferritic is weak, exhaustion due to sexual indulgence fecund, collaterals of the uterus damages, deficiency-cold of uterus, takes the photograph to receive unable, and the debility of CHONG and REN meridians, can not maintain caused by uterus.The medicament of research and development treatment uterine prolapse based on Chinese medicine, significant to the Health and Living quality improving women.
Summary of the invention
The object of this invention is to provide a kind of medicament for the treatment of uterine prolapse.
In order to realize object of the present invention, the invention provides a kind of medicament for the treatment of uterine prolapse, it is made up of the material of following weight portion: Radix Bauhiniae Hupehanae 10-20 part, Herba polygoni hydropiperis 10-20 part, Herba Lepisori Thunbergiani 5-15 part, Fructus pruni pubescentis 5-15 part, SEMEN ASTRAGALI COMPLANATI 5-15 part, Herba Artemisiae Selengensis 1-10 part, Radix Maesae Japonicae 5-15 part, Radix Polygoni Chinensis 5-15 part, Radix Glycyrrhizae 1-10 part, Herba Gnaphalii uliginosi 5-15 part, Herba hyperici attenuati 10-20 part, Radix seu Folium Tetracerae asiaticae 10-20 part, Herba Epilobii Himalayensis 10-20 part, Parmelia tinctorum Despr. 1-10 part, Cortex schizophragmatis integrifolii radicis 5-15 part, Pseudobulbus Pholidotae Chinensis 5-15 part, blue Jacob's ladder 20-30 part, Semen Nigellae 5-15 part.
Preferably, the medicament for the treatment of uterine prolapse of the present invention is made up of the material of following weight portion: Radix Bauhiniae Hupehanae 15 parts, Herba polygoni hydropiperis 15 parts, Herba Lepisori Thunbergiani 10 parts, Fructus pruni pubescentis 10 parts, SEMEN ASTRAGALI COMPLANATI 12 parts, Herba Artemisiae Selengensis 5 parts, Radix Maesae Japonicae 10 parts, Radix Polygoni Chinensis 12 parts, 8 parts, Radix Glycyrrhizae, Herba Gnaphalii uliginosi 10 parts, Herba hyperici attenuati 15 parts, Radix seu Folium Tetracerae asiaticae 20 parts, Herba Epilobii Himalayensis 15 parts, Parmelia tinctorum Despr. 10 parts, Cortex schizophragmatis integrifolii radicis 10 parts, Pseudobulbus Pholidotae Chinensis 12 parts, blue Jacob's ladder 20 parts, Semen Nigellae 12 parts.
More preferably, described medicament can be tablet, dispersible tablet, capsule, soft capsule, ointment or decoction.
The present invention also provides the purposes of compositions in the medicine of preparation treatment uterine prolapse, and described compositions is made up of the material of following weight portion: Radix Bauhiniae Hupehanae 10-20 part, Herba polygoni hydropiperis 10-20 part, Herba Lepisori Thunbergiani 5-15 part, Fructus pruni pubescentis 5-15 part, SEMEN ASTRAGALI COMPLANATI 5-15 part, Herba Artemisiae Selengensis 1-10 part, Radix Maesae Japonicae 5-15 part, Radix Polygoni Chinensis 5-15 part, Radix Glycyrrhizae 1-10 part, Herba Gnaphalii uliginosi 5-15 part, Herba hyperici attenuati 10-20 part, Radix seu Folium Tetracerae asiaticae 10-20 part, Herba Epilobii Himalayensis 10-20 part, Parmelia tinctorum Despr. 1-10 part, Cortex schizophragmatis integrifolii radicis 5-15 part, Pseudobulbus Pholidotae Chinensis 5-15 part, blue Jacob's ladder 20-30 part, Semen Nigellae 5-15 part.
Preferably, described compositions is made up of the material of following weight portion: Radix Bauhiniae Hupehanae 15 parts, Herba polygoni hydropiperis 15 parts, Herba Lepisori Thunbergiani 10 parts, Fructus pruni pubescentis 10 parts, SEMEN ASTRAGALI COMPLANATI 12 parts, Herba Artemisiae Selengensis 5 parts, Radix Maesae Japonicae 10 parts, Radix Polygoni Chinensis 12 parts, 8 parts, Radix Glycyrrhizae, Herba Gnaphalii uliginosi 10 parts, Herba hyperici attenuati 15 parts, Radix seu Folium Tetracerae asiaticae 20 parts, Herba Epilobii Himalayensis 15 parts, Parmelia tinctorum Despr. 10 parts, Cortex schizophragmatis integrifolii radicis 10 parts, Pseudobulbus Pholidotae Chinensis 12 parts, blue Jacob's ladder 20 parts, Semen Nigellae 12 parts.
More preferably, described medicine can be tablet, dispersible tablet, capsule, soft capsule, ointment or decoction.
In the present compositions, Radix Bauhiniae Hupehanae, Herba Gnaphalii uliginosi, Radix seu Folium Tetracerae asiaticae are monarch drug; Herba polygoni hydropiperis, Fructus pruni pubescentis, SEMEN ASTRAGALI COMPLANATI, Radix Polygoni Chinensis, Parmelia tinctorum Despr. are ministerial drug; Herba Lepisori Thunbergiani, Herba Artemisiae Selengensis, Radix Maesae Japonicae, Herba hyperici attenuati, Herba Epilobii Himalayensis, Cortex schizophragmatis integrifolii radicis, Pseudobulbus Pholidotae Chinensis, blue Jacob's ladder, Semen Nigellae are adjuvant drug; Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, for making medicine.
Caused by uterine prolapse is failed to keep an appointment mainly due to deficiency of QI in middle-JIAO or kidney qi loss, the debility of CHONG and REN meridians, dai channel, the principle that therefore its treatment should adhere to tonifying and lifting QI, the kidney invigorating takes off admittedly.The all medicines of medicament of the present invention share, play the merit of warm network cold expelling, benefiting qi and raising yang, strengthening spleen, tonifying kidney, astringency inducing uterus altogether, the effect that invigorating middle warmer has tune, negative and positive are all mended can be played, and few side effects, safe ready, treatment uterine prolapse good effect, get that effect is fast, cure rate is high, clinic is applied.
Detailed description of the invention
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustration of the present invention instead of limitation of the present invention.Essence according to the present invention all belongs to the scope of protection of present invention to the simple modification that the present invention carries out.Unless otherwise stated, the percent in the present invention is percetage by weight.
The preparation of embodiment medicament of the present invention
For decoction, the step of preparation process of medicament of the present invention is as follows:
Take Radix Bauhiniae Hupehanae 150 grams, Herba polygoni hydropiperis 150 grams, Herba Lepisori Thunbergiani 100 grams, Fructus pruni pubescentis 100 grams, SEMEN ASTRAGALI COMPLANATI 120 grams, Herba Artemisiae Selengensis 50 grams, Radix Maesae Japonicae 100 grams, Radix Polygoni Chinensis 120 grams, 80 grams, Radix Glycyrrhizae, Herba Gnaphalii uliginosi 100 grams, Herba hyperici attenuati 150 grams, Radix seu Folium Tetracerae asiaticae 200 grams, Herba Epilobii Himalayensis 150 grams, Parmelia tinctorum Despr. 100 grams, Cortex schizophragmatis integrifolii radicis 100 grams, Pseudobulbus Pholidotae Chinensis 120 grams, blue Jacob's ladder 200 grams, Semen Nigellae 120 grams, add 9000 ml waters, reflux 3 hours in the flask that condensing tube is housed, then filter, obtain filtrate 1 and filtering residue 1; 2) in described filtering residue 1, add 6000 ml waters, heat 1 hour in the flask that condensing tube is housed, filter, obtain filtrate 2 and filtering residue 2; 3) merge described filtrate 1, described filtrate 2, be cooled to room temperature, obtain final product.
The curative effect of experimental example medicament of the present invention
1 data and method
1.1 physical data
Diagnostic criteria: (1) conscious pudendum has lump to deviate from, companion's soreness of waist, tenesmus, increase the weight of during walking, and the thing that swells when the lighter puts down sleeping can bounce back.(2) different according to the degree of uterine prolapse, be clinically divided into III degree.I degree is light I degree 1.: cervix uteri is less than 4cm apart from hymen edge, but does not reach hymen edge.2. heavy I degree: cervix uteri has reached hymen edge, can see in vaginal orifice.II degree is light II degree 1.: cervix uteri emerges in outside vagina, but Gong Tishang is in intravaginal.2. heavy II degree: cervix uteri and part palace body emerge in outside vaginal orifice.III degree cervix uteri and body of uterus all emerge in outside vaginal orifice.
Selector closes uterine prolapsed patient 100 example stating diagnostic criteria, be divided into treatment group 50 example and matched group 50 routine.Wherein minimum 27 years old of the treatment group age, maximum 70 years old, average 45.2 years old; The course of disease 4 months-6 years, average 4.1 years; I degree prolapsus person 29 example, II degree prolapsus person 17 example, III degree 4 example.Minimum 24 years old of matched group age, maximum 68 years old, average 47.0 years old; The course of disease 6 months-8 years, average 4.0 years; I degree prolapsus person 27 example, II degree prolapsus person 18 example, III degree 5 example.Two groups of patients, at the equal not statistically significant of the difference of above-mentioned each side (p > 0.05), have comparability.
1.2 Therapeutic Method
Treatment group takes the decoction of the present invention prepared in embodiment, sooner or later takes for twice, 50 milliliters/time.Be a course for the treatment of with 10 days, treat 2 courses for the treatment of.Matched group takes BUZHONG YIQI WAN (authentication code: the accurate word Z11020244 of traditional Chinese medicines, Beijing Tongrentang Technology Development Co.ltd. Pharmaceutical Factory produces), and 1 bag (6 grams)/time, 2 times/day.Be a course for the treatment of with 10 days, treat 2 courses for the treatment of.
1.3 criterion of therapeutical effect
Cure: clinical symptom disappearance, examine cervix uteri mouth location restore in gynecological normal;
Effective: clinical symptom disappearance, examine in gynecological before cervix uteri mouth position is comparatively treated and obviously promote;
Effective: clinical symptoms, uterus are returned and received inspection in vagina situation and gynecological and all make moderate progress;
Invalid: clinical symptoms, uterus are returned and to be received in vagina situation, gynecological inspection without improving or very increasing the weight of.1.4 statistical analysis
Adopt the capable statistical analysis of SPSS13.0 software.Enumeration data adopts x
2inspection.With p < 0.05 for difference has statistical significance.
2 results
After treating two courses for the treatment of, the clinical efficacy of two groups relatively in table 1.As can be seen from Table 1, the efficient difference of two groups has statistical significance (p < 0.05).This shows that the clinical efficacy for the treatment of group is better than matched group, and medicament of the present invention has significant advantage in the treatment of uterine prolapse, is better than BUZHONG YIQI WAN.
The comparison of table 1 liang group clinical efficacy
Note: compare with matched group, * p<0.05
Claims (1)
1. treat the decoction of uterine prolapse for one kind, it is characterized in that being made by following method: take Radix Bauhiniae Hupehanae 150 grams, Herba polygoni hydropiperis 150 grams, Herba Lepisori Thunbergiani 100 grams, Fructus pruni pubescentis 100 grams, SEMEN ASTRAGALI COMPLANATI 120 grams, Herba Artemisiae Selengensis 50 grams, Radix Maesae Japonicae 100 grams, Radix Polygoni Chinensis 120 grams, 80 grams, Radix Glycyrrhizae, Herba Gnaphalii uliginosi 100 grams, Herba hyperici attenuati 150 grams, Radix seu Folium Tetracerae asiaticae 200 grams, Herba Epilobii Himalayensis 150 grams, Parmelia tinctorum Despr. 100 grams, Cortex schizophragmatis integrifolii radicis 100 grams, Pseudobulbus Pholidotae Chinensis 120 grams, blue Jacob's ladder 200 grams, Semen Nigellae 120 grams, add 9000 ml waters, reflux 3 hours in the flask that condensing tube is housed, then filter, obtain filtrate 1 and filtering residue 1, 2) in described filtering residue 1, add 6000 ml waters, heat 1 hour in the flask that condensing tube is housed, filter, obtain filtrate 2 and filtering residue 2, 3) merge described filtrate 1, described filtrate 2, be cooled to room temperature, obtain final product.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103099993A (en) * | 2013-01-22 | 2013-05-15 | 夏景香 | Traditional Chinese medicine combination for treating uterine prolapse |
| CN103385970A (en) * | 2013-08-06 | 2013-11-13 | 天津太平洋制药有限公司 | Medicament for treating uterine prolapse |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103099993A (en) * | 2013-01-22 | 2013-05-15 | 夏景香 | Traditional Chinese medicine combination for treating uterine prolapse |
| CN103385970A (en) * | 2013-08-06 | 2013-11-13 | 天津太平洋制药有限公司 | Medicament for treating uterine prolapse |
Non-Patent Citations (2)
| Title |
|---|
| 中医治疗子宫脱垂的研究进展;孙亚男;《四川中医》;20121031;第30卷(第9期);152-155 * |
| 中药内服外用治疗子宫脱垂43例;谢一红等;《实用中医药杂志》;20081031;第24卷(第10期);638 * |
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Inventor after: Dai Shufeng Inventor after: Liu Haixia Inventor before: Qin Fang |
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