CN103110847B - TCM (traditional Chinese medicine) preparation for treating endometriosis - Google Patents
TCM (traditional Chinese medicine) preparation for treating endometriosis Download PDFInfo
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- CN103110847B CN103110847B CN201310067242.8A CN201310067242A CN103110847B CN 103110847 B CN103110847 B CN 103110847B CN 201310067242 A CN201310067242 A CN 201310067242A CN 103110847 B CN103110847 B CN 103110847B
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- 239000003814 drug Substances 0.000 title claims abstract description 19
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- 201000009273 Endometriosis Diseases 0.000 title claims abstract description 12
- 241000426256 Cyanotis Species 0.000 claims abstract description 9
- 239000009526 Fructus Akebiae Substances 0.000 claims description 8
- 241001558017 Gynura Species 0.000 claims description 8
- 241000968028 Juncus amplifolius Species 0.000 claims description 8
- 239000008280 blood Substances 0.000 abstract description 12
- 210000004369 blood Anatomy 0.000 abstract description 10
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- 230000036407 pain Effects 0.000 abstract description 6
- 230000004087 circulation Effects 0.000 abstract description 4
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- 208000019255 Menstrual disease Diseases 0.000 abstract description 2
- 229940126680 traditional chinese medicines Drugs 0.000 abstract 2
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- 240000008027 Akebia quinata Species 0.000 abstract 1
- 235000007756 Akebia quinata Nutrition 0.000 abstract 1
- 241000132012 Atractylodes Species 0.000 abstract 1
- 244000104272 Bidens pilosa Species 0.000 abstract 1
- 235000010662 Bidens pilosa Nutrition 0.000 abstract 1
- 241001563039 Clinopodium megalanthum Species 0.000 abstract 1
- 235000016578 Geum urbanum Nutrition 0.000 abstract 1
- 244000308638 Geum urbanum Species 0.000 abstract 1
- 244000045531 Gynura pseudochina Species 0.000 abstract 1
- 241000574434 Jasminum laurifolium Species 0.000 abstract 1
- 241000226555 Leontopodium Species 0.000 abstract 1
- 241000219991 Lythraceae Species 0.000 abstract 1
- 241001520915 Phaenosperma globosum Species 0.000 abstract 1
- 244000292697 Polygonum aviculare Species 0.000 abstract 1
- 235000006386 Polygonum aviculare Nutrition 0.000 abstract 1
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- 231100000957 no side effect Toxicity 0.000 abstract 1
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- 208000005171 Dysmenorrhea Diseases 0.000 description 11
- 206010013935 Dysmenorrhoea Diseases 0.000 description 9
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- POZRVZJJTULAOH-LHZXLZLDSA-N danazol Chemical compound C1[C@]2(C)[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=CC2=C1C=NO2 POZRVZJJTULAOH-LHZXLZLDSA-N 0.000 description 1
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Abstract
The invention discloses a TCM (traditional Chinese medicine) preparation for treating endometriosis. The endometriosis belongs to the category of dysmenorrheal and menoxenia and the like, and mainly has symptoms such as abdominal pains and dysmenorrheal and the like caused by that the blood stasis lasts for a long time, and stagnation leads to pain after the qi-blood circulation is sluggish and the circulation of menstrual blood in the uterus is blocked due to artificial abortion, abortion, induced abortion and postoperative blood stasis. Therefore, the preparation disclosed by the invention is implemented through selecting traditional Chinese medicines such as jasminum laurifolium, Chinese leontopodium roots, sticktight, Stephania tetrandra S. Moore var. glabra Maxim, wild clove roots, gynura pseudochina, loosestrife, paleaceous Knotweed rhizome, latifolious rush rhizome, bighead atractylodes rhizome, phaenosperma globosa, fiveleaf akebia fruits, clinopodium megalanthum, viola orientalis, and arachnoid cyanotis roots, and preparing the traditional Chinese medicines into a decoction. Through clinical trials, the total effective rate is 96.7%, and the dysmenorrheal improvement rate is 96.0%, which are both superior to those in a control group; and especially the TCM preparation has no side effect in a treatment group.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of Chinese medicine preparation for the treatment of metrecotpia disease.
Background technology
Endometriosis refers to that the endometrial tissue with growth function appears at a kind of disease caused by other positions of health beyond cavity of uterus mucosa, belongs to the difficult and complicated illness of gynecological.Be current common gynecological disease, frequently-occurring disease, according to relevant statistics, in endometriosis patients, 80% has obvious dysmenorrhea, and 30%-50% merges infertile, this disease be mainly in 25-45 year Women of Childbearing Age, have a strong impact on patient's physically and mentally healthy and quality of life.Utilize Western medicine and abdominal to treat equal Shortcomings part clinically, recurrence and probability of again performing the operation all higher, side effect is large, and curative effect is unsatisfactory.Chinese traditional treatment has good effect, the advantage that side effect is little.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine preparation for the treatment of endometriosis.Endometriosis belongs to the categories such as traditional Chinese medical science dysmenorrhea, menoxenia, is mostly due to retention of blood stasis after fetal abortion, abortion, artificial abortion, operation, and long-pending stasis of blood punching is appointed, or cold accumulating in meridian, make QI-blood circulation not smooth, the circulation of uterus menses is hindered, and stasis of blood day of year is of a specified duration, stagnation of QI and blood may bring about pain, causes lower abdomen pain, the symptoms such as dysmenorrhea.
The object of the invention is to be achieved through the following technical solutions, the Chinese medicine preparation of this treatment endometriosis is made up of the Chinese medicine of following weight portion: Herba Jasmini laurifolii 10-20 part, Radix leontopodii sinensis 5-10 part, Herba Bidentis Bipinnatae 7-10 part, Radix Cissi Kerrii 5-7 part, Radix Luculiae intermediae 9-12 part, Gynura bodinieri Levl. 3-7 part, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 7-10 part, Rhizoma Polygoni Paleachi 10-15 part, Juncus amplifolius A. Camus 6-9 part, Rhizoma Atractylodis Macrocephalae 6-9 part, Herba Phaenospermatis globosae 10-15 part, Fructus Akebiae 3-5 part, Herba Stellariae paniculigerae 7-10 part, Radix violae delavayi 6-8 part, Radix Cyanotis arachnoideae 7-9 part.
Preferably, Herba Jasmini laurifolii 15 parts, Radix leontopodii sinensis 8 parts, Herba Bidentis Bipinnatae 9 parts, Radix Cissi Kerrii 6 parts, Radix Luculiae intermediae 11 parts, Gynura bodinieri Levl. 6 parts, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 8 parts, Rhizoma Polygoni Paleachi 12 parts, Juncus amplifolius A. Camus 7 parts, the Rhizoma Atractylodis Macrocephalae 8 parts, Herba Phaenospermatis globosae 13 parts, Fructus Akebiae 4 parts, Herba Stellariae paniculigerae 9 parts, Radix violae delavayi 7 parts, Radix Cyanotis arachnoideae 8 parts.
Preparation method uses boiling machine, and become every pair to be 200ml above-mentioned Chinese medicine decocting, every 100ml mono-bag is for subsequent use.
Fang Zhong: Herba Jasmini laurifolii, Radix leontopodii sinensis, Herba Bidentis Bipinnatae, Radix Cissi Kerrii heat-clearing and toxic substances removing, antiinflammatory diuresis, detumescence dissipating blood stasis; Radix Luculiae intermediae, Gynura bodinieri Levl., Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) promoting blood flow to regulate menstruation, anti-inflammatory analgetic; Rhizoma Polygoni Paleachi, Juncus amplifolius A. Camus fall apart blood hemostasis, regulating QI to relieve pain; The Rhizoma Atractylodis Macrocephalae, Herba Phaenospermatis globosae air making-up and spleen enlivening, dampness diuretic; Fructus Akebiae, Herba Stellariae paniculigerae depressed liver-energy dispersing and QI regulating, promoting blood circulation and stopping pain; Radix violae delavayi, Radix Cyanotis arachnoideae promoting the flow of QI in the collateral by warming the meridian, removing damp and stopping pain.
Clinical data
1, physical data my gynecological of institute in month November in August, 2007 to 2010 treat altogether endometriosis patients 120 example, patient is divided into treatment group and matched group at random, treatment group patient 60 example, the age at 25 ~ 45 years old, 36.8 years old mean age, the course of disease 1 ~ 5 year; Average 3.5 years, have dysmenorrhea situation person 50 example, the routine patient of matched group 60, the age at 22 ~ 48 years old, 35.6 years old mean age, the course of disease 1 ~ 6 year; Average 4 years, there is dysmenorrhea situation person 45 example.Two groups of patient ages and the data such as the state of an illness, the course of disease through statistical procedures, difference there are no significant meaning.P > 0.05, has comparability.
2, Therapeutic Method treatment group takes Chinese medicine preparation of the present invention, prescription is: Herba Jasmini laurifolii 15g, Radix leontopodii sinensis 8g, Herba Bidentis Bipinnatae 9g, Radix Cissi Kerrii 6g, Radix Luculiae intermediae 11g, Gynura bodinieri Levl. 6g, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 8g, Rhizoma Polygoni Paleachi 12g, Juncus amplifolius A. Camus 7g, Rhizoma Atractylodis Macrocephalae 8g, Herba Phaenospermatis globosae 13g, Fructus Akebiae 4g, Herba Stellariae paniculigerae 9g, Radix violae delavayi 7g, Radix Cyanotis arachnoideae 8g, use boiling machine, decocting into every secondary Chinese medicine is 200ml, every 100ml mono-bag, every day 2 times, each 100ml divides early, evening 2 times is oral, non-menstrual period are oral, and serveing on 3 months is 1 course for the treatment of.Matched group starts that danazol capsule of oral pill from menstruation the 1st day, and each serving with 0.2g, every day 2 times, serveing on 3 months is 1 course for the treatment of, terminates rear judgement curative effect the course for the treatment of.
3, criterion of therapeutical effect (1) reference " combination of Chinese and Western medicine diagnosis and treatment standard of Endometriosis) " formulate.Recovery from illness: symptom (comprising blood stasis syndrome) all disappears, the local such as pelvic lump sign disappears substantially, gestation or fertility in Sterility patient 3 years; Effective: symptom disappears substantially, pelvic lump reduces (compared with menstrual cycle inspection of the same period), though local sign exists, Sterility patient is become pregnant; Effective: symptom alleviates, pelvic lump is without increase or reduce slightly again, and drug withdrawal symptom in March does not increase the weight of, invalid: cardinal symptom is unchanged or worsen, and local patholoic change is in increasing the weight of trend.
(2) dysmenorrhea improves the diagnostic criteria of criterion of therapeutical effect with reference to version " new Chinese medicine guideline of clinical investigations " uterine displacement disease in 1997: recovery from illness: after treatment, primary symptom integration reduces > 4/5 before comparatively treating; Effective: after treatment, primary symptom integration reduces 1/2=4/5 before comparatively treating; Effective: after treatment, integration comparatively treats front minimizing >=1/3 but < 1/2; Invalid: after treatment, primary symptom integration reduces < 1/3 before comparatively treating.
4, therapeutic outcome (1) two group of patient treatment after 3 months comparitive study in table 1.
Table 1 liang group patient clinical comparitive study table
Treatment group total effective rate is 96.7%; Matched group total effective rate is 80.0%; Two groups are compared cure rate, and total effective rate treatment group is obviously better than matched group, and difference has significant.
(2) two groups of patient's dysmenorrheas are improved situation and are compared in table 2.
A table 2 liang group patient dysmenorrhea improves situation comparison sheet
Two groups of patient's dysmenorrheas are improved situation and are compared, and it is 96.0% that treatment group patient dysmenorrhea improves total effective rate, and matched group is 66.7%, two groups and compares, and diversity is very significant (P < 0.01).Dysmenorrhea is improved treatment group and is better than matched group.
5, untoward reaction treatment group does not find any side effect, drug safety; Matched group some patients has obvious side effect, 4 examples of wherein body weight increase, occurs 9 examples of edema, 7 examples of flush, and sound becomes 9 hoarse examples.
Detailed description of the invention
Embodiment one: take Herba Jasmini laurifolii 15g, Radix leontopodii sinensis 8g, Herba Bidentis Bipinnatae 9g, Radix Cissi Kerrii 6g, Radix Luculiae intermediae 11g, Gynura bodinieri Levl. 6g, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 8g, Rhizoma Polygoni Paleachi 12g, Juncus amplifolius A. Camus 7g, Rhizoma Atractylodis Macrocephalae 8g, Herba Phaenospermatis globosae 13g, Fructus Akebiae 4g, Herba Stellariae paniculigerae 9g, Radix violae delavayi 7g, Radix Cyanotis arachnoideae 8g.Use boiling machine, become every pair to be 200ml above-mentioned Chinese medicine decocting, every 100ml mono-bag is for subsequent use.
Embodiment two: take Herba Jasmini laurifolii 10g, Radix leontopodii sinensis 5g, Herba Bidentis Bipinnatae 10g, Radix Cissi Kerrii 5g, Radix Luculiae intermediae 12g, Gynura bodinieri Levl. 3g, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 10g, Rhizoma Polygoni Paleachi 10g, Juncus amplifolius A. Camus 6g, Rhizoma Atractylodis Macrocephalae 9g, Herba Phaenospermatis globosae 10g, Fructus Akebiae 3g, Herba Stellariae paniculigerae 10g, Radix violae delavayi 6g, Radix Cyanotis arachnoideae 9.Preparation method embodiment one.
Embodiment three: take Herba Jasmini laurifolii 20g, Radix leontopodii sinensis 10g, Herba Bidentis Bipinnatae 7g, Radix Cissi Kerrii 7g, Radix Luculiae intermediae 9g, Gynura bodinieri Levl. 7g, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 7g, Rhizoma Polygoni Paleachi 15g, Juncus amplifolius A. Camus 9g, Rhizoma Atractylodis Macrocephalae 6g, Herba Phaenospermatis globosae 15g, Fructus Akebiae 5g, Herba Stellariae paniculigerae 7g, Radix violae delavayi 8g, Radix Cyanotis arachnoideae 7g.Preparation method embodiment one.
Claims (1)
1. treat a Chinese medicine preparation for endometriosis, it is characterized in that this Chinese medicine preparation is made up of the Chinese medicine of following weight: Herba Jasmini laurifolii 15g, Radix leontopodii sinensis 8g, Herba Bidentis Bipinnatae 9g, Radix Cissi Kerrii 6g, Radix Luculiae intermediae 11g, Gynura bodinieri Levl. 6g, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 8g, Rhizoma Polygoni Paleachi 12g, Juncus amplifolius A. Camus 7g, Rhizoma Atractylodis Macrocephalae 8g, Herba Phaenospermatis globosae 13g, Fructus Akebiae 4g, Herba Stellariae paniculigerae 9g, Radix violae delavayi 7g, Radix Cyanotis arachnoideae 8g.
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| CN103316165B (en) * | 2013-07-05 | 2014-09-10 | 魏法虹 | Chinese herbal enema for treating pelvic inflammatory masses |
| CN103705823B (en) * | 2013-12-22 | 2016-06-29 | 李光彩 | A kind of Chinese medicine preparation treating cold blood stasis card primary dysmenorrhea |
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| CN102727715A (en) * | 2012-07-04 | 2012-10-17 | 杜晓娅 | Traditional Chinese medicine preparation of treating chronic pyelonephritis |
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| CN102727715A (en) * | 2012-07-04 | 2012-10-17 | 杜晓娅 | Traditional Chinese medicine preparation of treating chronic pyelonephritis |
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| Title |
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| 用活血化瘀法治疗肾盂肾炎的体会;李汉俊;《陕西中医》;19801231;第01卷(第03期);15-16,第16页右栏第2段 * |
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