CN104586407A - Multi-parameter physiological indication detection device and detection method thereof - Google Patents

Abstract

The invention discloses a multi-parameter physiological indication detection device and a detection method thereof, and belongs to the technical field of medical instrument detection equipment. A measuring device comprises a probe and a host, wherein the probe comprises a multi-parameter integrated signal acquisition component, a heat transfer component and a heat dissipation component; the host comprises a data processing module and a tablet computer. The detection method comprises the following steps: inputting parameter signals about environmental temperature and humidity, human body temperature and humidity, pulse, blood flow velocity and the like acquired by the probe to the host; analyzing and calculating data through a data processing module; controlling the signal acquisition time sequence of the data processing module through the tablet computer and realizing man-machine interaction; finally displaying a test result on the tablet computer. By adopting the multi-parameter physiological indication detection device and the detection method, a plurality of physiological parameter indications such as the environmental temperature and humidity, the body surface temperature and humidity, pulse, the degree of blood oxygen saturation, the blood flow velocity and hemoglobin concentration can be measured, and high integration of a product is realized. In particular, the device can be used for measuring the human body blood glucose concentration through the parameters in a non-invasive way.

Description

A kind of multi-parameter physiological indication checkout gear and detection method thereof

Technical field

The present invention relates to a kind of physiology indication detecting instrument, belong to medical apparatus and instruments checkout equipment technical field.

Background technology

At the medical apparatus and instruments Registering product that State Food and Drug Administration's inquiry is relevant, find domestic Chinese Medical Device Manufacturers and the import medical instrument also not having the multiple parameters such as non-invasive measurement blood glucose, hemoglobin, blood flow rate at present, commonplace product all can only detect one or two physiological parameters, as blood glucose meter (having wound or Wicresoft), hemometer (having wound or Wicresoft), pulse blood oxygen instrument (noinvasive) etc.Although have wound and Wicresoft's measurement method accuracy rate high because need to take blood sample, there is certain infection risk, while also bring many miseries to patient.Therefore a kind of noninvasive multiparameter armarium is studied significant.

The equipment of Non-invasive detection blood oxygen saturation is applied to some extent, as utilized spectra methods non-invasive measurement blood oxygen saturation in patent documentation CN1011O3921A (a kind of method and apparatus measuring blood oxygen saturation).Its theoretical basis is lambert Bill rule.The photodiode two kinds being sent different spectrum is placed on the opposite side placement photoelectric receiving arrangement of the same side at tested position of detection site, then calculates blood oxygen saturation according to the AC compounent ratio of the two kinds of photoelectric currents obtained.Also there are some problems in non-invasive measurement hemoglobin concentration, as the interference of composition in tissue, causes precision lower now.

Non-invasive measurement of blood sugar for human body concentration, at present a still challenge.A lot of scholar is had to propose a lot of method based on different principle, wherein United States Patent (USP) (US.Pat.NO.5975305; US.Pat.NO.20060094941) be realize a kind of heat based on metabolic rate heat conformation method-optics Noninvasive Blood Glucose Detection Methods the earliest.The energy that origin of heat in the method hypothesis body discharges in metabolism, and the main energy sources material of metabolism is saccharide, most histiocyte is produced by the aerobic oxidation process of glucose and obtains energy.Due in the state of the equilibrium, (static state) quantity of heat production and heat dissipation capacity numerically equal, so just can estimate blood glucose value by measuring the physiological parameter such as blood oxygen total amount and heat dissipation capacity.

United States Patent (USP) (US.Pat.NO.5795305 and US.Pat.NO.5924996) and Hitachi of Amada Co., Ltd. propose a kind of patent (patent No. ZL 03178742.8) being obtained blood glucose by detection of skin temperature, and need to carry out correcting through blood oxygen saturation and blood flow volume to obtain stable measurement data.The measuring principle of this blood sugar level measuring apparatus is also based on hot metabolism integration method, and its composition comprises: one, apparatus for measuring amount of heat: for measuring multiple shell temperature and ambient temperature to obtain the information of the heat of convective heat transfer for relevant with calculating the heat that dissipates from body surface and the heat of radiation delivery; Two, oxygen volume measurement device: for obtaining about the long-pending information of blood oxysome; Three, optical measuring device: for calculating hemoglobin concentration and hemoglobin saturation with oxygen.

There is following problem in above-mentioned patented technology: one is that human-computer interaction function is more weak, operation inconvenience, and longer-term storage can not detect data, is difficult to the regular rectification work realizing data; Two is that some parameter detecting precision are not high, needs to be improved further precision and the sensitivity of parameter detecting; Three be measure parameter comparatively single, do not effectively integrate each test parameter.

Summary of the invention

The object of this invention is to provide a kind of multi-parameter physiological indication checkout gear and method of testing, strengthen the human-computer interaction function of physiological detection instrument, improve parameter measurement precision, overcome the defect that test parameter is single.

Technical scheme of the present invention is as follows:

A kind of multi-parameter physiological indication checkout gear, this device comprises probe and main frame, uses wired or wireless communication between probe and main frame; Described probe comprises multiparameter integrated signal acquisition component, heat transfer component and thermal component; Described multiparameter integrated signal acquisition component comprise the infrared radiation sensor for detecting body surface and ambient temperature parameter, the humidity sensor for testing environment and body surface humidity parameter, infrared light emission array, infrared light receptor, for detecting near-end critesistor and the far-end critesistor of blood flow parameter; Described main frame comprises data processing module, and described data processing module comprises microprocessor, signal condition unit and memory element; Described signal condition unit comprises filtering and amplifying circuit, A/D change-over circuit and integrating circuit; The signal that multiparameter integrated signal acquisition component collects sends into microprocessor after signal condition cell processing, carries out computing by microprocessor to signal, result of calculation is sent into memory element and stores; Infrared light emission array is connected with the outlet line of microprocessor, it is characterized in that: described main frame also comprises panel computer, and this panel computer comprises communication protocol module, physio-parameter detection module, user interactive module and touch display screen; Panel computer is connected by serial line interface with data processing module, realizes two-way communication; Physio-parameter detection module sends the result obtained to user interactive module, and shows on touch display screen, realizes human-computer interaction function.

Described multi-parameter physiological indication checkout gear, is characterized in that: described panel computer adopts the panel computer of the Android operation system of ARM framework.

Described multi-parameter physiological indication checkout gear, is characterized in that: described thermal component adopts fin, and described fin is comb slab construction.

Described multi-parameter physiological indication checkout gear, is characterized in that: described probe adopts clamp type structure.

Described multi-parameter physiological indication checkout gear, is characterized in that: described heat transfer component adopts heat conductive bar, and described heat conductive bar adopts cross structure, nail construction, dumbbell structure, cylinder or hexahedron structure.

Described multi-parameter physiological indication checkout gear, is characterized in that: described heat conductive bar top is coated with layer gold.

A kind of multi-parameter physiological indication detection method of described device, is characterized in that the method comprises the steps:

1) physio-parameter detection module sends instruction by serial line interface, controls the collection that microprocessor carries out signal;

2) before probe is put at tested position, ambient temperature value T is obtained by far-end critesistor and infrared radiation sensor ₁, obtain ambient humidity H by humidity sensor ₁;

3), after probe is put at tested position, human temperature angle value T is obtained by near-end critesistor ₂, obtain human body humidity H by humidity sensor ₂;

4) human body blood oxygen saturation and pulse is measured: by the infrared light of infrared light emission array emitter four wavelength, wavelength is respectively 660nm, 730nm, 800nm and 940nm, utilize infrared remote receiver to receive through the optical signal behind tested position, utilize formula (1) to obtain human body blood oxygen saturation:

SpO ₂＝α ₂×R ²+α ₁×R+α ₀(1)

Wherein, SpO ₂for human body blood oxygen saturation, α ₀=100.72, α ₁=10.28, α ₂=-26.67, with be respectively the minima that 660nm and 940nm wavelength output intensity changes with pulse, with be respectively the maximum that 660nm and 940nm wavelength output intensity changes with pulse;

According to output intensity change frequency calculates pulse Pulse;

5) hemoglobin testing concentration Hgb: in blood constituent between each concentration relation as shown in formula (2),

$C_0=C_{\mathrm{Hb}}+C_{\mathrm{Hb}{O}_2}+C_{H_{2}O}+C_{\mathrm{other}}---\left(2\right)$

Wherein, C ₀for haemoconcentration, C _hbfor deoxy-hemoglobin concentrations, for oxygen is in conjunction with hemoglobin concentration, for water concentration, C _otherfor the concentration of residual components;

Solving equation group (3), obtains C _hbwith

$\left\{\begin{array}{c}\ln \left(\frac{I_0^{660}}{I^{660}}\right)=(C_{\mathrm{Hb}}{\mathrm{\ϵ}}_{\mathrm{Hb}}^{660}+C_{\mathrm{HbO}2}{\mathrm{\ϵ}}_{{\mathrm{HbO}}_2}^{660}+C_{H2O}{\mathrm{\ϵ}}_{H_{2}O}^{660})d_{\mathrm{pef}}^{660}+{\tilde{S}}_{660}\\ \ln \left(\frac{I_0^{940}}{I^{940}}\right)=(C_{\mathrm{Hb}}{\mathrm{\ϵ}}_{\mathrm{Hb}}^{940}+C_{\mathrm{HbO}2}{\mathrm{\ϵ}}_{\mathrm{Hb}{O}_2}^{940}+C_{H2O}{\mathrm{\ϵ}}_{H_{2}O}^{940})d_{\mathrm{pef}}^{940}+{\tilde{S}}_{940}\\ \ln \left(\frac{I_0^{730}}{I^{730}}\right)=(C_{\mathrm{Hb}}{\mathrm{\ϵ}}_{\mathrm{Hb}}^{730}+C_{\mathrm{Hb}O2}{\mathrm{\ϵ}}_{{\mathrm{HbO}}_2}^{730}+C_{H2O}{\mathrm{\ϵ}}_{H_{2}O}^{730})d_{\mathrm{pef}}^{730}+{\tilde{S}}_{730}\\ \ln \left(\frac{I_0^{800}}{I^{800}}\right)=(C_{\mathrm{Hb}}{\mathrm{\ϵ}}_{\mathrm{Hb}}^{800}+C_{\mathrm{HbO}2}{\mathrm{\ϵ}}_{{\mathrm{HbO}}_2}^{800}+C_{H2O}{\mathrm{\ϵ}}_{H_{2}O}^{800})d_{\mathrm{def}}^{800}+{\tilde{S}}_{800}\end{array}\right.---\left(3\right)$

Wherein, s is the decay factor that component of organization scattering causes, and the decay that concentration and scattering due to residual components cause is relatively little, regard constant as, ε represents material specific absorbance at a particular wavelength, I ₀represent the light intensity of incident illumination, I represents the light intensity after through tested position, d _pefthe path modification factor under specific wavelength, hemoglobin concentration $\mathrm{Hgb}=C_{\mathrm{Hb}}+C_{\mathrm{Hb}{O}_2};$

6) blood flow BF is calculated: put into the near-end critesistor behind tested position and far-end thermosensitive resistance by test, obtain the temperature variation curve at heat conductive bar two ends, calculate the difference of the average area of these two curves, utilize formula (4) to calculate blood flow

$\mathrm{BF}=a_{\stackrel{\‾}{s}}\×\stackrel{\‾}{S}+a_{s^{\′}}\×S^{\′}+a_v,S^{\′}=\frac{T_{j2}-T_{j1}}{t_2-t_1}---\left(4\right)$

In formula, BF is blood flow, a _{s '}, a _vfor constant, T _j1for heat conductive bar near-end is in the temperature of test start time, T _j2for heat conductive bar near-end is in the temperature of test finish time, t ₁for valid data start time point, t ₂for the end time point of valid data, s ₁for heat conductive bar near-end temperature averages, S ₂for heat conductive bar distal temperature meansigma methods;

7) calculating of blood glucose value: consider that the height of people, body weight, the impact at age are on the impact of model, blood glucose value formula (5) calculates:

G＝f(H,BF,SpO ₂,Hgb,High,Weight,Age) (5)

Wherein, H is the heat that body metabolism produces, and is calculated, H=g (T by ambient temperature and humidity, human temperature humidity, blood flow, pulse ₁, T ₂, H ₁, H ₂, BF, Pulse);

8) by step 2) ~ step 7) in the data storing that obtains of measurements and calculations to storage element, and be sent to physio-parameter detection module by serial connection mouth, data are sent to user interactive module by physio-parameter detection module, realize human-computer interaction function.

The present invention compared with prior art, have the following advantages and salience effect: 1. choose Android platform and carry out matching design Man Machine Interface, make up the weak tendency that digital signal processing (DSP) develops man-machine interface on the one hand, excellent based on the application interactivity of Android platform on the other hand, autgmentability is strong, construction cycle is short, can experience good client-side program by development of user easily; 2. human body multinomial physiological parameter index while, the height achieving detection system is integrated, and achieves the non-invasive measurement of human blood glucose concentration; 3. incorporate each detected parameters such as ambient temperature and humidity, improve shape and the technique of heat conductive bar, effectively improve accuracy of detection.

Accompanying drawing explanation

Fig. 1 is the hardware block diagram of multi-parameter physiological indication checkout gear provided by the invention.

Fig. 2 is the structural representation of multi-parameter physiological indication checkout gear probe.

Fig. 3 is temperature survey electrical bridge principle figure.

Fig. 4 is deoxyhemoglobin, the specific absorbance of HbO2 Oxyhemoglobin and water changes with light frequency.

Fig. 5 is heat trnasfer method schematic diagram.

Fig. 6 is heat conductive bar two ends signal examples.

Fig. 7 is the heat conductive bar structural representation of multi-parameter physiological indication checkout gear.

Fig. 8 is heat radiating fin structure (comb slab construction) schematic diagram of multi-parameter physiological indication checkout gear.

Fig. 9 is the man-machine interaction flow chart of multi-parameter physiological indication checkout gear.

In figure: 1-top cover; 2-infrared light emission array; 3-fin; 4-base; 5-circuit board; 6-infrared light receptor; 7-far-end critesistor; 8-heat conductive bar; 9-near-end critesistor; 10-humidity sensor; 11-infrared radiation sensor; Seat board is contacted under 12-; 81-layer gold.

Detailed description of the invention

Below in conjunction with the drawings and specific embodiments, the present invention is described in detail.

Fig. 1 is the hardware block diagram of multi-parameter physiological indication checkout gear provided by the invention, and this multi-parameter physiological indication checkout gear comprises probe and main frame; Described probe comprises multiparameter integrated signal acquisition component, heat transfer component and thermal component; Described multiparameter integrated signal acquisition component comprises infrared radiation sensor 11, humidity sensor 10, near-end critesistor 9, far-end critesistor 7, infrared light emission array 2 and infrared light receptor 6; Infrared radiation sensor 11 is for detecting body surface and ambient temperature parameter, and humidity sensor 10 is for testing environment and body surface humidity parameter; Near-end critesistor 9, far-end critesistor 7, infrared light emission array 2 and infrared light receptor 6 are for detecting blood flow parameter, infrared light emission array 2 and infrared light receptor 6 are also for detecting pulse, blood oxygen saturation and hemoglobin parameters, and the detected parameters of described infrared radiation sensor 11 and humidity sensor 10 etc. is all used for calculating glycemic parameters.

Described main frame comprises data processing module and panel computer, and described data processing module comprises microprocessor, signal condition unit and memory element; Described microprocessor uses DSP process chip; Described signal condition unit comprises filtering and amplifying circuit, A/D change-over circuit and integrating circuit; Described memory element comprises SD storage card; The signal that multiparameter integrated signal acquisition component collects sends into microprocessor after signal condition cell processing, carries out computing by microprocessor to signal, result of calculation is sent into memory element and stores; Infrared light emission array is connected with the outlet line of microprocessor; Described panel computer comprises communication protocol module, physio-parameter detection module, user interactive module and touch display screen, adopts the Android operation system of ARM framework; Described communication protocol module realizes order between data processing module and panel computer and data communication; Described physio-parameter detection module controls multiparameter detecting sensor integration probe by control data processing module, thus to realize in multiparameter detecting sensor integration probe each sensor to the collection of data; The detection instruction that described user interactive module provides for obtaining user, by communication protocol module, obtains physio-parameter detection module results; Described touch display screen is used for all control operations, and shows all detected parameters, including, but not limited to ambient temperature and humidity, body surface humiture, pulse, blood oxygen saturation, blood flow rate, hemoglobin concentration and blood sugar concentration.

Described data processing module is crossed serial line interface with dull and stereotyped computer expert and is connected, and realizes two-way communication; Use wired or wireless communication connection between described probe and main frame, complete the transmission of data.

Fig. 2 is the structural representation of multi-parameter physiological indication checkout gear probe, described probe adopts clip structure, comprises top cover 1, base 4, infrared light emission array 2, fin 3, circuit board 5, infrared light receptor 6, far-end critesistor 7, heat conductive bar 8, near-end critesistor 9, humidity sensor 10, infrared radiation sensor 11, lower contact seat board 12; Described infrared light emission array 2 and infrared light receptor 6 are positioned at the both sides at tested position, and positioned opposite; Heat conductive bar 8 one end near tested position is located at by described near-end critesistor 9, and heat conductive bar 8 one end away from tested position is located at by described far-end critesistor 7; The tested position of human body is placed between base 4 and top cover 1; Infrared light emission array 2 of the present invention is arranged in top cover 1, and described infrared radiation sensor 11, infrared light receptor 6 and heat conductive bar 8 are arranged in base 4, and arranges along human body detected part direction.

Fig. 9 is the workflow of user interactive module in panel computer: starting up's program, the main interface of display test; There are at main interface users' guidebook, newly-built user, user to detect and help options, during user's first time test, need a newly-built user; The essential information inputting user is needed during newly-built user; Newly-built user completes or clicks the interface occurring selecting user after user detects, and selects the user that this test is corresponding; Need afterwards to select the test mode of user, as on an empty stomach, 2 hours after the meal etc.; Start test afterwards, DSP starts power supply, and whether detect DSP power supply and connect correct, main frame sends test instruction and user profile to DSP; DSP collecting test environmental information, as found, environmental condition is not suitable for continuing test, then send correlated results to main frame, terminates this test; As environmental condition is suitable, ask user to put into tested position (as finger, ear etc.), detect after putting into tested position, DSP sends instruction to start to test relevant parameter; After having tested, DSP completes data and stores, and each parameter testing result is sent to main frame, and panel computer shows; Main frame sends order and cuts out DSP power supply, and test terminates.

The specific works flow process of signals collecting is: DSP issue an order, detection probe starts image data, what at this moment infrared radiation sensor 11 and humidity biography device 10 were measured respectively is environmental radiation temperature and ambient humidity, whether the ambient parameter that DSP verification test arrives is suitable, order is sent to main frame if improper, stop current test, if ambient parameter is suitable, detection probe is held on the tested position of human body (as hands refers to, ear etc.), what infrared radiation sensor 11 and humidity sensor 10 were measured respectively is human body tested position radiation temperature signal and ambient humidity, light and temperature signal, meanwhile, heat conductive bar 8 and tested position are (as hands refers to, ear etc.) contact, namely there is heat trnasfer phenomenon, because temperature changes, near-end temperature-sensitive electricity sun 9 can change with the resistance of far-end critesistor 7, resistance signal after this change detect by temperature sensing circuit, the light wave that infrared light emission array 2 is dispatched a car produces transmitted spectrum signal A afterwards by tested position (as finger, ear etc.), is received by infrared remote receiver 6.

Then, the signal that these measuring cells record is divided into three tunnels to be sent to microprocessor: human body tested position radiation temperature signal, environmental radiation temperature degree signal, tested position ambient humidity, light and temperature signal, ambient humidity signal and pressure signal enter microprocessor through filtering and amplifying circuit and A/D change-over circuit successively by transmission line; The resistance signal of near-end critesistor 9 and far-end critesistor 7 enters temperature sensing circuit by transmission line, changes resistance signal into temperature signal, and then temperature signal enters microprocessor through filtering and amplifying circuit and A/D change-over circuit; Transmitted light intensity signal Al ~ A4 enters microprocessor through single order filtering and amplifying circuit, integrating circuit and second order filtering and amplifying circuit successively.The work of infraluminescence array is controlled by emitter control circuit, and this emitter control circuit is connected with DSP by control circuit; Single order filtering and amplifying circuit is controlled by potentiometer switch circuit, and this potentiometer switch circuit is connected with DSP by control circuit; Second order filtering and amplifying circuit is then direct to be connected with DSP by control circuit.Like this, emitter control circuit, single order filtering and amplifying circuit and second order filtering and amplifying circuit are all subject to the control of DSP.

Under the participation and control of DSP, all signals are all transferred in DSP, and these signals obtain final result according to measuring multiple parameters of the present invention and computational methods.

The method of testing of parameters is as follows:

(1) measurement of ambient temperature and human body temperature is realized by critesistor, and the resistance of critesistor can increase along with the rising of temperature, meets relation:

$\mathrm{Rt}=R\×e^{B\×(1/T_1-1/T_2)}$

Wherein, Rt is that critesistor is at T ₁resistance at temperature; R is that critesistor is at T ₂nominal resistance under room temperature; B is the constant parameter of critesistor.

Utilize conventional, electric-resistance and critesistor composition electric bridge as shown in Figure 3, in figure, R1, R2, R3 are conventional, electric-resistance, RT is critesistor, V0, V1 are the magnitudes of voltage of test point, the resistance of critesistor changes when the temperature varies, and the change in resistance of conventional, electric-resistance is less, and the difference of V0 and V1 can change, obtained the difference of voltage by amplifying circuit and A/D convertor circuit, and then obtain the temperature value of environment and human body.

(2) humidity of environment can be obtained by humidity sensor, and humidity sensor has had the sensor chip of comparative maturity, directly amplifies the magnitude of voltage that it exports and samples.

(3) human body blood oxygen saturation and pulse is measured: utilize optical means to record, theoretical foundation is Lambert-Beer rule, when light impinges upon in something, incident intensity I and output intensity I ₀between have following relation:

To I and I ₀ratio to take the logarithm to obtain optical density A, that is:

A＝ln(I/I ₀)＝εcd

By the infrared light of infrared light emission array emitter four wavelength, wavelength is respectively 660nm, 730nm, 800nm and 940nm, utilizes infrared remote receiver to receive through the optical signal behind tested position, utilizes formula (1) to obtain human body blood oxygen saturation,

SpO ₂＝α ₂×R ²+α ₁×R+α ₀(1)

Wherein, SpO ₂for human body blood oxygen saturation, α ₀=100.72, α ₁=10.28, α ₂=-26.67, with the minima that the output intensity being respectively 660nm and 940nm wavelength changes with pulse, with be respectively the maximum that 660nm and 940nm wavelength output intensity changes with pulse;

According to output intensity change frequency calculates pulse Pulse;

(4) hemoglobin concentration

Water in blood of human body accounts for about 70% ~ 85%, accounts for 11% ~ 15% to normal person's hemoglobin concentration, and the main component of known blood of human body is water and hemoglobin.The percentage ratio of other compositions in blood is less than 19%.Following hypothesis can be done:

A most of composition of () blood is water and hemoglobin.

B the density of () normal condition hematochezia is constant (the whole blood density of normal condition servant is 1.048g/ml, and erythrocyte density is 1.085g/ml, and plasma density is 1.019g/ml, and plasma density change is less).

C optical attenuation that () is caused by scattering and by the average light path of the light of blood vessel with relation between each concentration in the little blood constituent of wavelength relationship as shown in formula (2),

$C_0=C_{\mathrm{Hb}}+C_{\mathrm{Hb}{O}_2}+C_{H_{2}O}+C_{\mathrm{other}}---\left(2\right)$

Wherein, C ₀for haemoconcentration, C _hbfor deoxy-hemoglobin concentrations, for oxygen is in conjunction with hemoglobin concentration, for water concentration, C _otherfor the concentration of residual components.

Due to tissue more complicated, there is strong scattering phenomenon to light, a large amount of statistical result shows, due to the impact of scattering, photon is random migration process between incident light source to photoelectric detector, and the total propagation path of light is " tortuous bow " type, and therefore Lambert-Beer's law needs to revise.What the absorption law under strong scattering can be similar to is expressed as:

$A=\ln \left(\frac{I}{I_0}\right)\mathrm{\ϵc}{d}_{\mathrm{pef}}+S$

Wherein, S is the decay factor that component of organization scattering causes, d _peffor opticpath modifying factor, c is the concentration of tested tissue composition, and d is the path that light penetrates, and ε is the specific absorbance of component of organization.

Solving equation (3) obtains C _hbwith

$\left\{\begin{array}{c}\ln \left(\frac{I_0^{660}}{I^{660}}\right)=(C_{\mathrm{Hb}}{\mathrm{\ϵ}}_{\mathrm{Hb}}^{660}+C_{\mathrm{HbO}2}{\mathrm{\ϵ}}_{{\mathrm{HbO}}_2}^{660}+C_{H2O}{\mathrm{\ϵ}}_{H_{2}O}^{660})d_{\mathrm{pef}}^{660}+{\tilde{S}}_{660}\\ \ln \left(\frac{I_0^{940}}{I^{940}}\right)=(C_{\mathrm{Hb}}{\mathrm{\ϵ}}_{\mathrm{Hb}}^{940}+C_{\mathrm{HbO}2}{\mathrm{\ϵ}}_{\mathrm{Hb}{O}_2}^{940}+C_{H2O}{\mathrm{\ϵ}}_{H_{2}O}^{940})d_{\mathrm{pef}}^{940}+{\tilde{S}}_{940}\\ \ln \left(\frac{I_0^{730}}{I^{730}}\right)=(C_{\mathrm{Hb}}{\mathrm{\ϵ}}_{\mathrm{Hb}}^{730}+C_{\mathrm{Hb}O2}{\mathrm{\ϵ}}_{{\mathrm{HbO}}_2}^{730}+C_{H2O}{\mathrm{\ϵ}}_{H_{2}O}^{730})d_{\mathrm{pef}}^{730}+{\tilde{S}}_{730}\\ \ln \left(\frac{I_0^{800}}{I^{800}}\right)=(C_{\mathrm{Hb}}{\mathrm{\ϵ}}_{\mathrm{Hb}}^{800}+C_{\mathrm{HbO}2}{\mathrm{\ϵ}}_{{\mathrm{HbO}}_2}^{800}+C_{H2O}{\mathrm{\ϵ}}_{H_{2}O}^{800})d_{\mathrm{def}}^{800}+{\tilde{S}}_{800}\end{array}\right.---\left(3\right)$

Wherein, s is the decay factor that component of organization scattering causes, and the decay that concentration and scattering due to residual components cause is relatively little, regard constant as, ε represents material specific absorbance at a particular wavelength, I ₀represent the light intensity of incident illumination, I represents the light intensity after through tested position, d _pefthe path modification factor under specific wavelength, hemoglobin concentration fig. 4 gives wave-length coverage to be changed at the specific absorbance of 700 ~ 1300nm deoxyhemoglobin, HbO2 Oxyhemoglobin and water.660nm, 730nm, 800nm, 940nm tetra-wavelength are selected to measure.Just hemoglobin concentration can be calculated according to the light intensity value recorded.

(5) blood flow utilizes heat trnasfer method to measure

In Fig. 5, heat conductive bar two ends are provided with critesistor, and heat conductive bar temperature, lower than tissue temperature, after being contacted heat conductive bar one end, can produce heat transmission between tested portion faces and heat conductive bar with tested portion faces, and then tested spot temperature is changed.On heat conductive bar, the temperature variation of arbitrfary point depends on the amount of heat transfer from tested position to heat conductive bar, and the heat of heat trnasfer finally depends on the blood flow in blood capillary.Therefore, by measuring the variations in temperature of arbitrfary point on heat conductive bar, just blood flow can be extrapolated.

Fig. 6 is the temperature variation curve being calculated heat conductive bar two ends by the data of sensor acquisition, and transverse axis is the time, and the longitudinal axis is temperature value, and upper broken line is near-end temperature sensor numerical value, and below solid line is distal temperature sensor value.Blood flow BF can represent with formula (4):

$\mathrm{BF}=a_{\stackrel{\‾}{s}}\×\stackrel{\‾}{S}+a_{s^{\′}}\×S^{\′}+a_v,S^{\′}=\frac{T_{j2}-T_{j1}}{t_2-t_1}---\left(4\right)$

In formula, BF is blood flow, a _{s '}, a _vfor constant, T _j1for heat conductive bar near-end is in the temperature of test start time, T _j2for heat conductive bar near-end is in the temperature of test finish time, t ₁for valid data start time point, t ₂for the end time point of valid data, s ₁for heat conductive bar near-end temperature averages, S ₂for heat conductive bar distal temperature meansigma methods.

In the temperature test of heat conductive bar two ends, even if adopt high-precision circuit design, still there is certain test error, described device utilizes ambient temperature estimated value to carry out offset correction to each temperature sensor, improves precision.

Fig. 7 is heat conductive bar, and critesistor is equipped with at its two ends, and in order to test blood flow more accurately, the shape of heat conductive bar needs to be optimized, and obtains using decussate texture effect better through emulation.The waste heat once having tested rear heat conductive bar needs to leave as early as possible, to start as early as possible to test next time, devises comb flat plate heat spreading apparatus, as shown in Figure 8 for this reason.

(6) human blood glucose concentration utilizes metabolic heat conformation method to calculate

Metabolic heat conformation blood sugar test method was proposed by people such as Ok Kyung Cho in 2004.They think that glucose in blood and oxygen enter in histiocyte under the effect of blood circulation, are then converted into energy, water and carbon dioxide through peroxidization.Major part power conversion becomes heat, and the heat be converted is dispersed in the middle of surrounding with convection current and radiation two kinds of modes.Therefore body metabolism heat be blood sugar concentration, oxygen-supplying amount function and and blood sugar concentration, oxygen-supplying amount positive correlation, and by test heat dissipation capacity method can predict metabolic heat.Its theory thinks that the constant of body temperature is maintained by glucose oxidation heat production and the two-part balance of heat dissipation, and does following hypothesis:

1) metabolic heat production and heat dissipation capacity can be considered equal to body in the quiescent state.

2) metabolic heat production is the function of blood sugar concentration and oxygen-supplying amount.

3) oxygen-supplying amount is the function of blood oxygen saturation and Regional tissue blood flow.

4) human-body radiating completes primarily of convection current, radiation two kinds of forms.

Known according to hypothesis, metabolism heat is the function of blood glucose concentration value and oxygen supply amount, oxygen supply amount is determined by the blood flow of blood oxygen saturation, hemoglobin concentration and local organization again, therefore metabolic heat production is the function of blood glucose concentration value, blood oxygen saturation, hemoglobin concentration and blood flow, and can be represented by the formula:

H＝f ₀(G,BF,SpO ₂,Hgb)

In formula: H is metabolism heat, BF is blood flow, SpO ₂for blood oxygen saturation, Hgb is hemoglobin concentration, and G is blood glucose concentration value.If record metabolism heat, blood oxygen saturation and blood flow, consider that the height of people, body weight, the impact at age are on the impact of model, blood glucose value formula (5) calculates:

G＝f(H,BF,SpO ₂,Hgb,High,Weight,Age) (5)

Wherein, H is the heat that body metabolism produces, and is calculated, H=g (T by ambient temperature and humidity, human temperature humidity, blood flow, pulse ₁, T ₂, H ₁, H ₂, BF, Pulse).

Claims (7)

1. a multi-parameter physiological indication checkout gear, this device comprises probe and main frame, uses wired or wireless communication between probe and main frame; Described probe comprises multiparameter integrated signal acquisition component, heat transfer component and thermal component; Described multiparameter integrated signal acquisition component comprise the infrared radiation sensor (11) for detecting body surface and ambient temperature parameter, the humidity sensor (10) for testing environment and body surface humidity parameter, infrared light emission array (2), infrared light receptor (6), for detecting near-end critesistor (9) and the far-end critesistor (7) of blood flow parameter; Described main frame comprises data processing module, and described data processing module comprises microprocessor, signal condition unit and memory element; Described signal condition unit comprises filtering and amplifying circuit, A/D change-over circuit and integrating circuit; The signal that multiparameter integrated signal acquisition component collects sends into microprocessor after signal condition cell processing, carries out computing by microprocessor to signal, result of calculation is sent into memory element and stores; Infrared light emission array is connected with the outlet line of microprocessor, it is characterized in that: described main frame also comprises panel computer, and this panel computer comprises communication protocol module, physio-parameter detection module, user interactive module and touch display screen; Panel computer is connected by serial line interface with data processing module, realizes two-way communication; Physio-parameter detection module sends the result obtained to user interactive module, and shows on touch display screen, realizes human-computer interaction function.

2. multi-parameter physiological indication checkout gear as claimed in claim 1, is characterized in that: described panel computer adopts the Android operation system of ARM framework.

3. multi-parameter physiological indication checkout gear as claimed in claim 1, is characterized in that: described thermal component adopts fin, and described fin is comb slab construction.

4. the multi-parameter physiological indication checkout gear as described in claim 1,2 or 3, is characterized in that: described probe adopts clamp type structure.

5. the multi-parameter physiological indication checkout gear as described in claim 1,2 or 3, is characterized in that: described heat transfer component adopts heat conductive bar, and described heat conductive bar adopts cross structure, nail construction, dumbbell structure, cylinder or hexahedron structure.

6. multi-parameter physiological indication checkout gear as claimed in claim 5, is characterized in that: described heat conductive bar top is coated with layer gold (81).

7. adopt a kind of multi-parameter physiological indication detection method of device as described in claim 1,2 or 3, it is characterized in that the method comprises the steps:

1) physio-parameter detection module sends instruction by serial line interface, controls the collection that microprocessor carries out signal;

2) before probe is put at tested position, ambient temperature value T is obtained by far-end critesistor and infrared radiation sensor ₁, obtain ambient humidity H by humidity sensor ₁;

3), after probe is put at tested position, human temperature angle value T is obtained by near-end critesistor ₂, obtain human body humidity H by humidity sensor ₂;

4) human body blood oxygen saturation and pulse is measured: by the infrared light of infrared light emission array emitter four wavelength, wavelength is respectively 660nm, 730nm, 800nm and 940nm, utilize infrared remote receiver to receive through the optical signal behind tested position, utilize formula (1) to obtain human body blood oxygen saturation:

SpO ₂＝α ₂×R ²+α ₁×R+α ₀(1)

Wherein, SpO ₂for human body blood oxygen saturation, α ₀=100.72, α ₁=10.28, α ₂=-26.67, with be respectively the minima that 660nm and 940nm wavelength output intensity changes with pulse, with be respectively the maximum that 660nm and 940nm wavelength output intensity changes with pulse;

According to output intensity change frequency calculates pulse Pulse;

5) hemoglobin testing concentration Hgb: in blood constituent between each concentration relation as shown in formula (2),

$C_0=C_{\mathrm{Hb}}+C_{\mathrm{Hb}{O}_2}+C_{H_{2}O}+C_{\mathrm{other}}---\left(2\right)$

Wherein, C ₀for haemoconcentration, C _hbfor deoxy-hemoglobin concentrations, for oxygen is in conjunction with hemoglobin concentration, for water concentration, C _otherfor the concentration of residual components;

Solving equation group (3), obtains C _hbwith :

$\left\{\begin{array}{c}\ln \left(\frac{I_0^{660}}{I^{660}}\right)=(C_{\mathrm{Hb}}{\mathrm{\ϵ}}_{\mathrm{Hb}}^{660}+C_{\mathrm{HbO}2}{\mathrm{\ϵ}}_{{\mathrm{HbO}}_2}^{660}+C_{H2O}{\mathrm{\ϵ}}_{H_{2}O}^{660})d_{\mathrm{pef}}^{660}+{\tilde{S}}_{660}\\ \ln \left(\frac{I_0^{940}}{I^{940}}\right)=(C_{\mathrm{Hb}}{\mathrm{\ϵ}}_{\mathrm{Hb}}^{940}+C_{\mathrm{HbO}2}{\mathrm{\ϵ}}_{{\mathrm{HbO}}_2}^{940}+C_{H2O}{\mathrm{\ϵ}}_{H_{2}O}^{940})d_{\mathrm{pef}}^{940}+{\tilde{S}}_{940}\\ \ln \left(\frac{I_0^{730}}{I^{730}}\right)=(C_{\mathrm{Hb}}{\mathrm{\ϵ}}_{\mathrm{Hb}}^{730}+C_{\mathrm{HbO}2}{\mathrm{\ϵ}}_{{\mathrm{HbO}}_2}^{730}+C_{h2O}{\mathrm{\ϵ}}_{H_{2}O}^{730})d_{\mathrm{pef}}^{730}+{\tilde{S}}_{730}\\ \ln \left(\frac{I_0^{800}}{I^{800}}\right)=(C_{\mathrm{Hb}}{\mathrm{\ϵ}}_{\mathrm{Hb}}^{800}+C_{\mathrm{HbO}2}{\mathrm{\ϵ}}_{{\mathrm{HbO}}_2}^{800}+C_{H2O}{\mathrm{\ϵ}}_{H_{2}O}^{800})d_{\mathrm{pef}}^{800}+{\tilde{S}}_{800}\end{array}\right.---\left(3\right)$

Wherein, s is the decay factor that component of organization scattering causes, and the decay that concentration and scattering due to residual components cause is relatively little, and S ~ regard constant as, ε represents material specific absorbance at a particular wavelength, I ₀represent the light intensity of incident illumination, I represents the light intensity after through tested position, d _pefit is the path modification factor under specific wavelength;

Hemoglobin concentration $\mathrm{Hgb}=C_{\mathrm{Hb}}+C_{{\mathrm{HbO}}_2;}$

6) blood flow BF is calculated: put into the near-end critesistor behind tested position and far-end thermosensitive resistance by test, obtain the temperature variation curve at heat conductive bar two ends, calculate the difference of the average area of these two curves, utilize formula (4) to calculate blood flow

$\mathrm{BF}=a_{\stackrel{\‾}{s}}\×\stackrel{\‾}{S}+a_{s^{\′}}\×S^{\′}+a_v,S^{\′}\frac{T_{j2}-T_{j1}}{t_2-t_1}---\left(4\right)$

In formula, BF is blood flow, a _s, a _{s '}, a _vfor constant, T _j1for heat conductive bar near-end is in the temperature of test start time, T _j2for heat conductive bar near-end is in the temperature of test finish time, t ₁for valid data start time point, t ₂for the end time point of valid data, s ₁for heat conductive bar near-end temperature averages, S ₂for heat conductive bar distal temperature meansigma methods;

7) calculating of blood glucose value: consider that the height of people, body weight, the impact at age are on the impact of model, blood glucose value formula (5) calculates:

G＝f(H,BF,SpO ₂,Hgb,High,Weight,Age) (5)

Wherein, H is the heat that body metabolism produces, and is calculated, H=g (T by ambient temperature and humidity, human temperature humidity, blood flow, pulse ₁, T ₂, H ₁, H ₂, BF, Pulse);

8) by step 2) ~ step 7) in the data storing that obtains of measurements and calculations to storage element, and be sent to physio-parameter detection module by serial line interface, data are sent to user interactive module by physio-parameter detection module, realize human-computer interaction function.