CN105455782A - Non-invasive spine marrow lesion detector - Google Patents
Non-invasive spine marrow lesion detector Download PDFInfo
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- CN105455782A CN105455782A CN201510953275.1A CN201510953275A CN105455782A CN 105455782 A CN105455782 A CN 105455782A CN 201510953275 A CN201510953275 A CN 201510953275A CN 105455782 A CN105455782 A CN 105455782A
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- detector
- light source
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- main control
- bone marrow
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
- A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
- A61B5/417—Evaluating particular organs or parts of the immune or lymphatic systems the bone marrow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
- A61B5/0004—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by the type of physiological signal transmitted
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
Abstract
The invention discloses a non-invasive spine marrow lesion detector. According to the invention, optical signals carrying marrow information are converted into electric signals by detecting units through near infrared technology; data is obtained through signal processing; hemodynamic parameters of the marrow can be obtained according to the modified Beer-Lambert law; and therefore spine marrow lesions can be diagnosed. The detector is noninvasive, can continuously and rapidly diagnose lesions, is low in cost and quite high in reliability, is suitable for diagnosing spine marrow lesions, and can effectively avoid a phenomena that patients are in pain when the patients are diagnosed through other methods.
Description
Technical field
The present invention relates to medical instruments field, particularly a kind of non-intrusion type spinal column bone marrow lesion detection instrument.
Background technology
Bone marrow is rich celliferous connective tissue in bone, has hemopoietic, produces the critical function such as thrombin, immunity.Bone marrow lesion comprises tumor tissues and invades the bone marrow infiltration pathological changes that causes of bone marrow and the disease such as inflammation, wound causes bone marrow inflammatory water seepage to swell.Wherein multiple myeloma (MM) is a kind of the malignant plasma cell dyscrasia, and its tumor cell originates from the abnormality proliferation of bone marrow mesoplasmatocyte, and plasma cell is bone-marrow-derived lymphocyte grows the cell of final function phases.Therefore multiple myeloma can be grouped into the scope of B lymphocytic lymphoma.Current WHO is classified as the one of B cell lymphoma, is called plasma cell myeloma/plasmocytoma.It is characterized by bone marrow plasma cells paraplasm excessively to generate with monoclonal immunoglobulin or light chain (M albumen), only a few patient can be the non-secreting type MM not producing M albumen.Multiple myeloma is often with multiple osteolytic infringement, hypercalcemia, anemia, kidney damage.Because the generation of normal immunoglobulin is suppressed, therefore easily there is various bacterial infection.Sickness rate is estimated as 2 ~ 3,/10 ten thousand, and M-F is 1.6:1, most patient age >40 year.Simultaneously MM is the second haematological malignancies the most often diagnosed in the Western countries, be only about 15000 new cases at U.S.'s annual morbidity, and when considering all tumors, MM is the cancer mortality reason of the 14.Unfortunately, current MM is regarded as the disease that cannot cure and MM patient for treatment later the average survival time cycle is about 3 years, and 5 years survival rates are the survival rate of more than about 10%, 10 years is about 3-5%, so early stage diagnosis is abnormal important.
Method through consulting existing clinical diagnosis spinal column bone marrow lesion has: (1) bone marrow biopsy, by bone marrow aspiration bone marrow extraction fluid samples, by hyperplasia degree, plasmocyte infiltrating degree and the Reproduction methods etc. analyzed in myeloid tissue, spinal column bone marrow lesion is diagnosed, but this have the diagnostic method of wound very painful to patient, and be difficult to carry out diagnosis confirmation continuously, bone wears the probability that comparatively blindly there are failure and mistaken diagnosis in position simultaneously, as therapeutic evaluation means, repeatedly repeatedly to carry out and not easily by patient is accepted.(2) X, CT and MRI observation spinal cord image carrys out diagnosis of vertebral bone marrow lesion, although the method is noinvasive, price is very expensive, and cost is too high.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, a kind of non-intrusion type spinal column bone marrow lesion detection instrument is provided, by the mode adopting infrared light non-intruding to detect, realize the diagnosis to spinal column bone marrow lesion, and effectively prevent the misery that other diagnostic methods bring to patient.
Technical scheme of the present invention is: a kind of non-intrusion type spinal column bone marrow lesion detection instrument, comprising: probe module, light source driver module, channel selecting module, data processing module, main control module, supply module and memory module;
Described probe module comprises more than one and one light source that is a kind of for time division emission and more than one wavelength light, and is arranged on the detector around light source, the signal that described detector is returned for detecting detected part transmission;
Described light source driver module is connected with main control module, and under the control of main control module, driving light source is lighted or extinguished;
Described channel selecting module is connected with main control module, under the control of main control module, select detector;
Described data processing module is connected with detector, is converted to digital signal for the signal received by detector, and by this digital data transmission to main control module;
This digital signal is carried out date processing by described main control module, the data after process is transferred to memory module and stores, and by wired or wireless mode, the data after process is transferred to external equipment simultaneously;
Described supply module is used for powering to probe module, light source driving, channel selecting module, data processing module, main control module and memory module.
Further, described probe comprises more than one and one light source for time division emission four kinds of different wavelengths of light; The wave-length coverage of described four kinds of different wavelengths of light is respectively: 600nm ~ 700nm, 700nm ~ 800nm, 800nm ~ 900nm, 900nm ~ 1000nm.
Further, described light source and detector are in centered by light source, and detector is around the cross layout of light source; Or centered by light source, detector is around the circulating type layout of light source; Or centered by detector, light source is around the cross layout of detector; Or centered by detector, light source is around detector rings geometric pattern layout.
Further, described detector is light-sensitive detector, and described detector is at least one.
Further, the distance range between described detector center and light source center is 20mm ~ 40mm.
Further, described data processing module comprises amplifying unit, filter unit and AD conversion unit, signal for being received by detector carries out processing and amplifying by amplifying unit, then Filtering Processing is carried out by filter unit, digital signal is obtained again by AD conversion unit, and by this digital data transmission to main control module.
Further, described supply module comprises two kinds of electric source modes, and a kind of is cable power pattern for fixing diagnosis, and another is the portable power source pattern for mobile diagnostics.
Further, probe module adopts flexible material to make, and described light source and detector embed flexible material.
Further, described data handling procedure is specially: detector measurement obtains initial beam intensity I
o, transmitted light intensity I, according to Beer-Lambert law, obtains optical density O.D, the material amount concentration C according to following formulae discovery test substance:
Wherein, λ
ifor wavelength, ε be backscatter extinction logarithmic ratio, l is optical path length.
Beneficial effect of the present invention is: a kind of non-intrusion type myeleterosis detector of the present invention, adopt near infrared light technology, by detector, the optical signal carrying spinal cord information is converted into the signal of telecommunication, pass through signal processing again, data measured, by the Beer-Lambert law revised, obtain the hemodynamic parameter in spinal cord, thus spinal column bone marrow lesion is diagnosed.Detector noinvasive of the present invention, can diagnose continuously, cheap, diagnosis rapidly and reliability is high, be applicable to the diagnosis to spinal column bone marrow lesion, and effectively prevent the misery that other diagnostic methods bring to patient.
Accompanying drawing explanation
Fig. 1 is a kind of non-intrusion type myeleterosis detector architecture system block diagram of the present invention.
Fig. 2 is that single source provided by the invention and multiple light-sensitive detector cross are popped one's head in layout.
Fig. 3 is single source provided by the invention and multiple light-sensitive detector circular probe layout.
Fig. 4 is that single light source provided by the invention and paired multiple light-sensitive detector crosss are popped one's head in layout.
Fig. 5 is single light source provided by the invention and paired multiple light-sensitive detector circular probe layouts.
Fig. 6 is multiple light courcess provided by the invention and single light-sensitive detector circular probe layout.
Detailed description of the invention
Below in conjunction with the drawings and the specific embodiments, the present invention program is described in further detail.
As shown in Figure 1, be a kind of non-intrusion type spinal column bone marrow lesion detection instrument of the present invention, comprise: probe module, light source driver module, channel selecting module, data processing module, main control module, supply module and memory module.
Described probe module comprises more than one and one light source that is a kind of for time division emission and more than one wavelength light, and is arranged on the detector around light source, the signal that described detector is returned for detecting detected part transmission.
Popping one's head in relevant with follow-up date processing to the layout of light source, can be as shown in Figure 2, and centered by single source, multiple detector is around the cross layout of light source; Or as shown in Figure 3, once centered by individual light source, multiple probe is around the circulating type layout of light source; Or as shown in Figure 4, once centered by individual light source, paired multiple detectors are around the cross layout of light source; Or, as shown in Figure 5, centered by single source, paired multiple detectors around circulating type layout; Or as shown in Figure 6, centered by detector, multiple light source is around the circulating type layout of detector.Fig. 2, Fig. 3, Fig. 4, Fig. 5, Fig. 6 are only for illustration of summary of the invention of the present invention, and probe module topology layout of the present invention is not limited to the form of Fig. 2, Fig. 3, Fig. 4, Fig. 5, Fig. 6.Distance between described light source center and described light-sensitive detector center is 25mm ~ 40mm; The all wavelengths that light source comprises, in 600nm-980nm scope, typical wavelength combinations at least comprises a wavelength at 700nm-800nm, a wavelength is at 800nm-900nm, each wavelength light that light source comprises can be lighted according to set sequential by light source driver module drived control respectively or extinguish, the minimum response degree of light-sensitive detector will meet the optical power signals that can detect under light source low-power, such as OPT101.
Probe module is made by flexible material, to slow down spinal column build-up of pressure, light source and detector is embedded flexible material, when measuring light source and detector not with contact skin, strengthen comfort.
Described light source driver module is connected with main control module, and under the control of main control module, driving light source is lighted or extinguished.
Described channel selecting module is connected with main control module, under the control of main control module, select detector.
Described data processing module is connected with detector, is converted to digital signal for the signal received by detector, and by this digital data transmission to main control module; Because the primary signal of detector collection is the voltage signal characterizing light intensity attenuation, the voltage signal received by detector at digital signal processing module carries out processing and amplifying by amplifying unit, then Filtering Processing is carried out by filter unit, digital signal is obtained again by AD conversion unit, and by this digital data transmission to main control module.
This digital signal is carried out date processing by described main control module, the data after process is transferred to memory module and stores, and by wired or wireless mode, the data after process is transferred to external equipment simultaneously; Main control module carries out date processing to digital signal, data can be detected mainly due to each detector, the wavelength simultaneously lighted in the different moment is different, so each probe detection of each moment to data there is different implication, need store with the certain form of certain rule or pass to host computer process.
Described supply module is used for powering to main control module, probe module, channel selecting module, light source driver module, data processing module and memory module.
Main control module is the control core of whole system, comprises and controls the work of light source driving chip, carries out periodic sampling, process data, control data transmission and storage according to setting sequential; Wherein, the data of storage be collect comprise the bone marrow information signal of telecommunication, the Beer-Lambert law by revising is converted into hemodynamic parameter change, such as blood oxygen, blood appearance, blood flow etc., thus diagnose spinal column bone marrow lesion.The chip of the Control Cooling such as main control module can select 51, ARM, FPGA realizes.
Data transmission and memory module, select the pattern can selecting wireless transmission, wire transmission as required, storage can adopt the mode such as main frame and extension storage to carry out storage data.
Supply module, point two sets of plan, one powers, for fixing diagnosis for cable power; One is portable power source pattern, removablely diagnoses, and realizes mobile diagnostics by power storage cell or replaceable battery.
Main control module can carry out data transmission by wired mode and external equipment, such as, data transmission etc. and between computer; Also can wirelessly transmit, such as carry out data by mobile devices such as the transmission means such as bluetooth, wifi and mobile phone plane plates transmit and store, and by the host computer on these external equipments, data are processed to the human parameters drawing needs, thus realize diagnosing spinal column bone marrow lesion.
Operation principle of the present invention is: master control module controls light source drives, by the specific wavelength of certain timing strobe point bright light source, light-sensitive detector receives the optical attenuation variable signal that optical transport is returned simultaneously, gating passage then Signal transmissions to data processing module, by the amplification in data processing module, filtering, analog to digital conversion circuit, convert the signal into the digital signal of needs, for main control module analyzing and processing, data after analyzing and processing are sent to memory device by wireless or wired mode by main control module, complete transmission and the storage of data as required.Because Oxygenated blood Lactoferrin, deoxyhemoglobin, water to have the absorption spectrum of notable difference near infrared light spectral coverage, the near infrared light of multi-wavelength at their absorptance of near infrared spectral range, there is obvious difference, so can be utilized to measure Hb and the Hbo2 in blood.Light intensity I corresponding to different wave length can be recorded, based on Beer-Lambert law by probe:
wherein, O.D represents optical density, λ
irepresent the light of different wave length, I
ofor inciding the initial beam intensity in medium, I is the transmitted light intensity measured, and ε is extinction coefficient, and C is the thing mass concentration of assimilate, and l is optical path length.According to Beer-Lambert law, when detector measurement obtains I
o, I, can according to wavelength X
i, backscatter extinction logarithmic ratio ε and optical path length l, obtain the material amount concentration C of measured matter.Thus the material concentration of blood oxygen in spinal cord, blood appearance, water etc. can be obtained, by judging whether the parameters such as blood oxygen in spinal cord, blood appearance, water exceed range of normal value, draw diagnostic result.
Light source in the present invention can adopt four wavelength LED of EPITEX company to realize; Light source drives and Texas Instrument TLC series multichannel light source drive chip can be used to realize; The process core that main control module, data processing module use can adopt the STM32F103 series microprocessor of STMicw Electronics to realize; Data transmission and store sample serial ports turn USB and TF card; Power-supply system can provide 3.3V, 5V voltage of current stabilization.
Those of ordinary skill in the art will appreciate that, embodiment described here is to help reader understanding's principle of the present invention, should be understood to that protection scope of the present invention is not limited to so special statement and embodiment.For a person skilled in the art, the present invention can have various modifications and variations.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within right of the present invention.
Claims (9)
1. a non-intrusion type spinal column bone marrow lesion detection instrument, is characterized in that, comprising: probe module, light source driver module, channel selecting module, data processing module, main control module, supply module and memory module;
Described probe module comprises more than one and one light source that is a kind of for time division emission and more than one wavelength light, and is arranged on the detector around light source, the signal that described detector is returned for detecting detected part transmission;
Described light source driver module is connected with main control module, and under the control of main control module, driving light source is lighted or extinguished;
Described channel selecting module is connected with main control module, under the control of main control module, select detector;
Described data processing module is connected with detector, is converted to digital signal for the signal received by detector, and by this digital data transmission to main control module;
This digital signal is carried out date processing by described main control module, the data after process is transferred to memory module and stores, and by wired or wireless mode, the data after process is transferred to external equipment simultaneously;
Described supply module is used for powering to probe module, light source driving, channel selecting module, data processing module, main control module and memory module.
2. a kind of non-intrusion type spinal column bone marrow lesion detection instrument according to claim 1, it is characterized in that, described probe comprises more than one and one light source for time division emission four kinds of different wavelengths of light; The wave-length coverage of described four kinds of different wavelengths of light is respectively: 600nm ~ 700nm, 700nm ~ 800nm, 800nm ~ 900nm, 900nm ~ 1000nm.
3. a kind of non-intrusion type spinal column bone marrow lesion detection instrument according to claim 1, is characterized in that, described light source and detector are in centered by light source, and detector is around the cross layout of light source; Or centered by light source, detector is around the circulating type layout of light source; Or centered by detector, light source is around the cross layout of detector; Or centered by detector, light source is around detector rings geometric pattern layout.
4. a kind of non-intrusion type spinal column bone marrow lesion detection instrument according to claim 1, it is characterized in that, described detector is light-sensitive detector, and described detector is at least one.
5. a kind of non-intrusion type spinal column bone marrow lesion detection instrument according to claim 1, it is characterized in that, the distance range between described detector center and light source center is 20mm ~ 40mm.
6. a kind of non-intrusion type spinal column bone marrow lesion detection instrument according to claim 1, it is characterized in that, described data processing module comprises amplifying unit, filter unit and AD conversion unit, signal for being received by detector carries out processing and amplifying by amplifying unit, then Filtering Processing is carried out by filter unit, digital signal is obtained again by AD conversion unit, and by this digital data transmission to main control module.
7. a kind of non-intrusion type spinal column bone marrow lesion detection instrument according to claim 1, it is characterized in that, described supply module comprises two kinds of electric source modes, and a kind of is cable power pattern for fixing diagnosis, and another is the portable power source pattern for mobile diagnostics.
8. a kind of non-intrusion type spinal column bone marrow lesion detection instrument according to claim 1, is characterized in that, probe module adopts flexible material to make, and described light source and detector embed flexible material.
9. a kind of non-intrusion type spinal column bone marrow lesion detection instrument according to claim 1, it is characterized in that, described data handling procedure is specially: detector measurement obtains initial beam intensity I
o, transmitted light intensity I, according to Beer-Lambert law, obtains optical density O.D, the material amount concentration C according to following formulae discovery test substance:
Wherein, λ
ifor wavelength, ε be backscatter extinction logarithmic ratio, l is optical path length.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106618501A (en) * | 2016-12-29 | 2017-05-10 | 哈尔滨工业大学 | Tumor imaging system based on near-infrared spectrum blood oxygen concentration measurement and experiment detection method of system |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1103573A (en) * | 1993-12-11 | 1995-06-14 | 梅良模 | Analysing and measuring instrument for bone marrow tissue of human body with optical fibre sensor |
| WO2007113570A1 (en) * | 2006-04-05 | 2007-10-11 | The Science And Technology Facilities Council | Raman analysis of tissue |
| WO2008129532A2 (en) * | 2007-04-19 | 2008-10-30 | Mor Research Applications Ltd. | Device system and method for monitoring and controlling blood analyte levels |
| US20100105998A1 (en) * | 2008-10-28 | 2010-04-29 | Cas Medical Systems, Inc. | Method and apparatus for spectrophotometric based oximetry of spinal tissue |
| CN101949840A (en) * | 2010-08-17 | 2011-01-19 | 中国农业大学 | Quick and nondestructive detection method for myohemoglobin of raw meat and system thereof |
| CN104173059A (en) * | 2014-09-04 | 2014-12-03 | 电子科技大学 | Optical non-intrusive shock monitor and detection method thereof |
| CN104352230A (en) * | 2014-11-10 | 2015-02-18 | 电子科技大学 | Non-invasive thrombosis detector |
| CN104352221A (en) * | 2014-11-10 | 2015-02-18 | 电子科技大学 | Portable type optical noninvasive breast self-inspection instrument |
| CN104586407A (en) * | 2014-01-16 | 2015-05-06 | 清华大学 | Multi-parameter physiological indication detection device and detection method thereof |
-
2015
- 2015-12-17 CN CN201510953275.1A patent/CN105455782A/en active Pending
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1103573A (en) * | 1993-12-11 | 1995-06-14 | 梅良模 | Analysing and measuring instrument for bone marrow tissue of human body with optical fibre sensor |
| WO2007113570A1 (en) * | 2006-04-05 | 2007-10-11 | The Science And Technology Facilities Council | Raman analysis of tissue |
| WO2008129532A2 (en) * | 2007-04-19 | 2008-10-30 | Mor Research Applications Ltd. | Device system and method for monitoring and controlling blood analyte levels |
| WO2008129532A3 (en) * | 2007-04-19 | 2010-02-25 | C.G.M.3 Ltd | Device system and method for monitoring and controlling blood analyte levels |
| US20100105998A1 (en) * | 2008-10-28 | 2010-04-29 | Cas Medical Systems, Inc. | Method and apparatus for spectrophotometric based oximetry of spinal tissue |
| CN101949840A (en) * | 2010-08-17 | 2011-01-19 | 中国农业大学 | Quick and nondestructive detection method for myohemoglobin of raw meat and system thereof |
| CN104586407A (en) * | 2014-01-16 | 2015-05-06 | 清华大学 | Multi-parameter physiological indication detection device and detection method thereof |
| CN104173059A (en) * | 2014-09-04 | 2014-12-03 | 电子科技大学 | Optical non-intrusive shock monitor and detection method thereof |
| CN104352230A (en) * | 2014-11-10 | 2015-02-18 | 电子科技大学 | Non-invasive thrombosis detector |
| CN104352221A (en) * | 2014-11-10 | 2015-02-18 | 电子科技大学 | Portable type optical noninvasive breast self-inspection instrument |
Non-Patent Citations (3)
| Title |
|---|
| TAKAFUMI HAMAOKA 等: "Near-infrared spectroscopy/imaging for monitoring muscle oxygenation and oxidative metabolism in healthy and diseased humans", 《JOURNAL OF BIOMEDICAL OPTICS》 * |
| 单小峰 等: "近红外光谱监测系统用于检测腓骨瓣血氧饱和度的研究", 《中华口腔医学杂志》 * |
| 王裕清 等: "《生物机械工程导论》", 31 March 2006 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106618501A (en) * | 2016-12-29 | 2017-05-10 | 哈尔滨工业大学 | Tumor imaging system based on near-infrared spectrum blood oxygen concentration measurement and experiment detection method of system |
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