CN104583753B - 用于生物样本的处理和成像的系统和方法 - Google Patents

用于生物样本的处理和成像的系统和方法 Download PDF

Info

Publication number
CN104583753B
CN104583753B CN201380045120.7A CN201380045120A CN104583753B CN 104583753 B CN104583753 B CN 104583753B CN 201380045120 A CN201380045120 A CN 201380045120A CN 104583753 B CN104583753 B CN 104583753B
Authority
CN
China
Prior art keywords
sample
samples
imaging
processing
unit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201380045120.7A
Other languages
English (en)
Chinese (zh)
Other versions
CN104583753A (zh
Inventor
A.D.科尔文
R.J.菲尔金斯
J.谢
N.陈
K.A.沙伊克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leica Microsystems CMS GmbH
Original Assignee
General Electric Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by General Electric Co filed Critical General Electric Co
Publication of CN104583753A publication Critical patent/CN104583753A/zh
Application granted granted Critical
Publication of CN104583753B publication Critical patent/CN104583753B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N1/31—Apparatus therefor
    • G01N1/312—Apparatus therefor for samples mounted on planar substrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Optics & Photonics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Microscoopes, Condenser (AREA)
CN201380045120.7A 2012-06-29 2013-06-26 用于生物样本的处理和成像的系统和方法 Active CN104583753B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/538,898 US9164015B2 (en) 2012-06-29 2012-06-29 Systems and methods for processing and imaging of biological samples
US13/538898 2012-06-29
PCT/US2013/047814 WO2014004622A1 (en) 2012-06-29 2013-06-26 Systems and methods for processing and imaging of biological samples

Publications (2)

Publication Number Publication Date
CN104583753A CN104583753A (zh) 2015-04-29
CN104583753B true CN104583753B (zh) 2017-12-01

Family

ID=48917676

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380045120.7A Active CN104583753B (zh) 2012-06-29 2013-06-26 用于生物样本的处理和成像的系统和方法

Country Status (9)

Country Link
US (1) US9164015B2 (enExample)
EP (1) EP2867646B1 (enExample)
JP (1) JP6263529B2 (enExample)
KR (1) KR102100241B1 (enExample)
CN (1) CN104583753B (enExample)
AU (1) AU2013280429B2 (enExample)
NZ (1) NZ702867A (enExample)
SG (1) SG11201408773QA (enExample)
WO (1) WO2014004622A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9817221B2 (en) * 2012-06-29 2017-11-14 General Electric Company Systems and methods for processing and imaging of biological samples
HU230739B1 (hu) * 2013-02-28 2018-01-29 3Dhistech Kft. Berendezés és eljárás tárgylemezek automatikus festésére, fedésére, digitalizálására integrált tárgylemez festő-fedő-digitalizáló automata berendezés segítségével
PL3196875T3 (pl) 2014-09-12 2019-10-31 Sony Corp Urządzenie nadawcze, sposób nadawania, urządzenie odbiorcze i sposób odbioru
CN104181142A (zh) * 2014-09-19 2014-12-03 中国科学院自动化研究所 分子影像成像验证系统和方法
US10839509B2 (en) 2015-07-10 2020-11-17 3Scan Inc. Spatial multiplexing of histological stains
CN112987483B (zh) * 2016-03-31 2022-10-21 大日本印刷株式会社 校准用滑动玻璃
CN105891208B (zh) * 2016-04-13 2019-03-26 华中科技大学 用于构建标准图谱数据集的细胞构筑信息获取方法
JP7174371B2 (ja) * 2019-08-23 2022-11-17 国立大学法人千葉大学 データセット生成システム及びデータセット生成方法
KR102654655B1 (ko) * 2020-10-20 2024-04-05 한양대학교 산학협력단 초고해상도 형광 현미경 이미징 방법 및 초고해상도 형광 현미경 이미징 장치
KR102619825B1 (ko) * 2020-10-20 2024-01-03 한양대학교 산학협력단 초고해상도 형광 현미경용 이미징 버퍼 용액 및 이를 이용한 초고해상도 형광 현미경 이미징 방법
WO2022102748A1 (ja) * 2020-11-12 2022-05-19 株式会社GramEye 顕微鏡検査支援装置、顕微鏡検査支援方法、自動染色装置、自動染色物質推定システム、プログラム、及び記録媒体

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1107892A (zh) * 1993-08-27 1995-09-06 霍夫曼-拉罗奇有限公司 同时监测多个扩增反应并对其进行分析
WO2001042796A1 (en) * 1999-12-13 2001-06-14 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health & Human Services, The National Institutes Of Health High-throughput tissue microarray technology and applications
CN1650159A (zh) * 2002-04-26 2005-08-03 万堂医药系统公司 具有固定载玻片平台的自动化分子病理学装置
US20060088928A1 (en) * 2002-12-20 2006-04-27 Dakocytomation Denmark A/S Method and apparatus for automatic staining of tissue samples
US20080113440A1 (en) * 2006-10-06 2008-05-15 Leica Biosystems Melbourne Pty Ltd Method and Apparatus for Tissue Sample Processing
US20100141752A1 (en) * 2008-12-04 2010-06-10 Tatsuki Yamada Microscope System, Specimen Observing Method, and Computer Program Product
US20100183216A1 (en) * 2009-01-21 2010-07-22 Sysmex Corporation Cell image processing apparatus, cell image processing method and computer program product
US20100189321A1 (en) * 2009-01-23 2010-07-29 Olympus Corporation Image processing system, image processing device and image processing terminal
CN101983327A (zh) * 2008-04-02 2011-03-02 通用电气公司 生物样本的反复染色
US20110070606A1 (en) * 2008-04-25 2011-03-24 Constitution Medical, Inc. Systems and methods for analyzing body fluids
CN102016600A (zh) * 2008-04-23 2011-04-13 通用电气健康护理生物科学股份公司 分配机构在分液收集器中的定位
US20120135458A1 (en) * 2010-11-30 2012-05-31 General Electric Company Closed loop monitoring of automated molecular pathology system

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6022700A (en) 1998-03-12 2000-02-08 Intelligent Imaging Innovations, Inc. High throughput biological sample preparation device and methods for use thereof
US7951612B2 (en) * 1999-07-08 2011-05-31 Lee H. Angros In situ heat induced antigen recovery and staining apparatus and method
AU2003245499A1 (en) 2002-06-14 2003-12-31 Chromavision Medical Systems, Inc. Automated slide staining apparatus
JP4537231B2 (ja) 2005-03-07 2010-09-01 独立行政法人理化学研究所 多重蛍光からの蛍光色素濃度の推定方法および多重蛍光からの蛍光強度の推定方法
US7873193B2 (en) 2005-06-21 2011-01-18 Carl Zeiss Microimaging Gmbh Serial section analysis for computer-controlled microscopic imaging
US8244021B2 (en) 2006-12-20 2012-08-14 Ventana Medical Systems, Inc. Quantitative, multispectral image analysis of tissue specimens stained with quantum dots
US9008378B2 (en) 2006-12-20 2015-04-14 The Board Of Trustees Of The Leland Stanford Junior University Arrangement and imaging of biological samples
CA2692066C (en) * 2007-07-10 2017-03-14 Ventana Medical Systems, Inc. Apparatus and method for biological sample processing
JP2012515931A (ja) * 2008-04-25 2012-07-12 ウィンケルマン、ジェイムズ 全血球数及び白血球百分率を決定するシステム及び方法
US8310531B2 (en) 2009-08-03 2012-11-13 Genetix Corporation Methods and apparatuses for processing fluorescence images
JP5801410B2 (ja) * 2010-11-10 2015-10-28 コンスティテューション・メディカル・インコーポレイテッドＣｏｎｓｔｉｔｕｔｉｏｎ Ｍｅｄｉｃａｌ， Ｉｎｃ． 検査用に生物試料を準備するための自動化されたシステムおよび方法

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1107892A (zh) * 1993-08-27 1995-09-06 霍夫曼-拉罗奇有限公司 同时监测多个扩增反应并对其进行分析
WO2001042796A1 (en) * 1999-12-13 2001-06-14 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health & Human Services, The National Institutes Of Health High-throughput tissue microarray technology and applications
US20100255532A1 (en) * 2002-04-26 2010-10-07 Charles Lemme Automated Molecular Pathology Apparatus Having Fixed Slide Platforms
CN1650159A (zh) * 2002-04-26 2005-08-03 万堂医药系统公司 具有固定载玻片平台的自动化分子病理学装置
US20060088928A1 (en) * 2002-12-20 2006-04-27 Dakocytomation Denmark A/S Method and apparatus for automatic staining of tissue samples
US20080113440A1 (en) * 2006-10-06 2008-05-15 Leica Biosystems Melbourne Pty Ltd Method and Apparatus for Tissue Sample Processing
CN101983327A (zh) * 2008-04-02 2011-03-02 通用电气公司 生物样本的反复染色
CN102016600A (zh) * 2008-04-23 2011-04-13 通用电气健康护理生物科学股份公司 分配机构在分液收集器中的定位
US20110070606A1 (en) * 2008-04-25 2011-03-24 Constitution Medical, Inc. Systems and methods for analyzing body fluids
US20100141752A1 (en) * 2008-12-04 2010-06-10 Tatsuki Yamada Microscope System, Specimen Observing Method, and Computer Program Product
US20100183216A1 (en) * 2009-01-21 2010-07-22 Sysmex Corporation Cell image processing apparatus, cell image processing method and computer program product
US20100189321A1 (en) * 2009-01-23 2010-07-29 Olympus Corporation Image processing system, image processing device and image processing terminal
US20120135458A1 (en) * 2010-11-30 2012-05-31 General Electric Company Closed loop monitoring of automated molecular pathology system

Also Published As

Publication number Publication date
JP2015522853A (ja) 2015-08-06
US20140001337A1 (en) 2014-01-02
WO2014004622A1 (en) 2014-01-03
SG11201408773QA (en) 2015-02-27
NZ702867A (en) 2017-08-25
EP2867646A1 (en) 2015-05-06
KR102100241B1 (ko) 2020-04-13
AU2013280429A1 (en) 2015-01-22
CN104583753A (zh) 2015-04-29
EP2867646B1 (en) 2022-04-27
KR20150024423A (ko) 2015-03-06
US9164015B2 (en) 2015-10-20
AU2013280429B2 (en) 2017-05-11
JP6263529B2 (ja) 2018-01-17

Similar Documents

Publication Publication Date Title
CN104583753B (zh) 用于生物样本的处理和成像的系统和方法
KR101884490B1 (ko) 자동화 분자 병리진단 시스템의 폐루프 모니터링
AU2023202795A1 (en) Method and apparatus for volumetric imaging of a three-dimensional nucleic acid containing matrix
US6713264B2 (en) Process and device for the screening of molecules with regard to their individual binding behaviour towards at least one given ligand
US20200391210A1 (en) System and method for automated single cell processing and analyses
US20230296484A1 (en) Systems and methods for serial staining and imaging
US20220167950A1 (en) Systems and methods for processing stool samples
CN116802463A (zh) 具有共焦成像的用于微孔板的通用多功能检测系统
Huber et al. Micro fluorescence in situ hybridization (μFISH) for spatially multiplexed analysis of a cell monolayer
WO2018045978A1 (en) Apparatus and method for multiplexed rotating imaging bioassays
Denner et al. High-content analysis in preclinical drug discovery
CN111033238A (zh) 定量的液体活检诊断系统与方法
US9817221B2 (en) Systems and methods for processing and imaging of biological samples
US20220064719A1 (en) Method of calibration of mfish using slides
CN120584178A (zh) 多种检测模式的测定系统、检测方法及其模式切换方法
JP2007534936A (ja) 標的分子とプローブ分子の間の相互作用を分析する装置
EP4325206A1 (en) Method for compensating defective partitions of a microfluidic chip
Pilling et al. High Content Imaging in Drug Discovery
Garg et al. Assay Development and Automation in High Content Screening
Tyler et al. Exploring uncharted spatial biology with ChipCytometry highly multiplexed imaging
WO2025218675A1 (zh) 多种检测模式的测定系统、检测方法及其模式切换方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
TR01 Transfer of patent right
TR01 Transfer of patent right

Effective date of registration: 20210818

Address after: Massachusetts, USA

Patentee after: Globegroup life technology consulting America Co.,Ltd.

Address before: New York State, USA

Patentee before: General Electric Co.

TR01 Transfer of patent right
TR01 Transfer of patent right

Effective date of registration: 20220111

Address after: Germany Wetzlar

Patentee after: LEICA MICROSYSTEMS CMS GmbH

Address before: Massachusetts

Patentee before: Globegroup life technology consulting America Co.,Ltd.