CN104583400A - 用于调节pten表达的组合物和方法 - Google Patents

用于调节pten表达的组合物和方法 Download PDF

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Publication number
CN104583400A
CN104583400A CN201380037603.2A CN201380037603A CN104583400A CN 104583400 A CN104583400 A CN 104583400A CN 201380037603 A CN201380037603 A CN 201380037603A CN 104583400 A CN104583400 A CN 104583400A
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China
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nucleotide
oligonucleotide
single stranded
sequence
prc2
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Pending
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CN201380037603.2A
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English (en)
Chinese (zh)
Inventor
阿瑟·M·克里格
罗梅什·苏布拉马尼安
詹姆斯·麦克斯维根
珍妮·T·李
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General Hospital Corp
Translate Bio Inc
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General Hospital Corp
RaNA Therapeutics Inc
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Publication of CN104583400A publication Critical patent/CN104583400A/zh
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
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    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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CN201380037603.2A 2012-05-16 2013-05-16 用于调节pten表达的组合物和方法 Pending CN104583400A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261648041P 2012-05-16 2012-05-16
US61/648,041 2012-05-16
US201361785885P 2013-03-14 2013-03-14
US61/785,885 2013-03-14
PCT/US2013/041389 WO2013173605A1 (en) 2012-05-16 2013-05-16 Compositions and methods for modulating pten expression

Publications (1)

Publication Number Publication Date
CN104583400A true CN104583400A (zh) 2015-04-29

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CN201380037603.2A Pending CN104583400A (zh) 2012-05-16 2013-05-16 用于调节pten表达的组合物和方法

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US (1) US20150159161A1 (https=)
EP (1) EP2850187A4 (https=)
JP (1) JP2015519057A (https=)
CN (1) CN104583400A (https=)
AU (1) AU2013262706A1 (https=)
BR (1) BR112014028646A2 (https=)
CA (1) CA2873776A1 (https=)
EA (1) EA201492118A1 (https=)
WO (1) WO2013173605A1 (https=)

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AU2012308320C1 (en) 2011-09-14 2018-08-23 Translate Bio Ma, Inc. Multimeric oligonucleotide compounds
US10837014B2 (en) 2012-05-16 2020-11-17 Translate Bio Ma, Inc. Compositions and methods for modulating SMN gene family expression
BR112014028631A2 (pt) 2012-05-16 2017-10-17 Rana Therapeutics Inc composições e métodos para modulação da expressão da família de genes da hemoglobina
EA201492122A1 (ru) 2012-05-16 2015-10-30 Рана Терапьютикс, Инк. Композиции и способы для модулирования экспрессии utrn
EA201492116A1 (ru) 2012-05-16 2015-05-29 Рана Терапьютикс, Инк. Композиции и способы для модулирования экспрессии mecp2
SG11201407483YA (en) 2012-05-16 2014-12-30 Rana Therapeutics Inc Compositions and methods for modulating smn gene family expression
AU2013262699A1 (en) 2012-05-16 2015-01-22 Rana Therapeutics, Inc. Compositions and methods for modulating ATP2A2 expression
US20150247141A1 (en) 2012-09-14 2015-09-03 Rana Therapeutics, Inc. Multimeric oligonucleotide compounds
IL288931B2 (en) 2013-03-14 2025-05-01 Alnylam Pharmaceuticals Inc Compositions comprising a complementary portion of C5 IRNA and methods of using them
WO2016040589A1 (en) * 2014-09-12 2016-03-17 Alnylam Pharmaceuticals, Inc. Polynucleotide agents targeting complement component c5 and methods of use thereof
WO2016070060A1 (en) 2014-10-30 2016-05-06 The General Hospital Corporation Methods for modulating atrx-dependent gene repression
US10758558B2 (en) 2015-02-13 2020-09-01 Translate Bio Ma, Inc. Hybrid oligonucleotides and uses thereof
WO2016149455A2 (en) 2015-03-17 2016-09-22 The General Hospital Corporation The rna interactome of polycomb repressive complex 1 (prc1)
EP3368089B1 (en) 2015-10-26 2025-11-05 Translate Bio Ma, Inc. Nanoparticle formulations for delivery of nucleic acid complexes
AU2017209307B2 (en) * 2016-01-20 2023-06-15 Dana-Farber Cancer Institute, Inc. Compositions and methods for screening and identifying clinically aggressive prostate cancer
US11584932B2 (en) 2016-11-01 2023-02-21 The Research Foundation For The State University Of New York 5-halouracil-modified microRNAs and their use in the treatment of cancer
US11118182B2 (en) 2016-11-17 2021-09-14 Ramot At Tel-Aviv University Ltd. Modulators of human KAI1 metastasis suppressor gene, methods and uses thereof
CA3043768A1 (en) 2016-11-29 2018-06-07 PureTech Health LLC Exosomes for delivery of therapeutic agents
CN109022462B (zh) * 2017-06-08 2021-12-21 中山大学附属第一医院 一种PTEN基因的上游开放阅读框31aa-uORF核苷酸及其编码的多肽的应用
US20200208152A1 (en) 2017-09-08 2020-07-02 Mina Therapeutics Limited Stabilized sarna compositions and methods of use
WO2019048632A1 (en) 2017-09-08 2019-03-14 Mina Therapeutics Limited STABILIZED COMPOSITIONS OF SMALL ACTIVATORY RNA (PARNA) OF HNF4A AND METHODS OF USE
US20220281911A1 (en) 2019-08-19 2022-09-08 Mina Therapeutics Limited Oligonucleotide conjugate compositions and methods of use
WO2021262919A2 (en) 2020-06-26 2021-12-30 The Research Foundation For The State University Of New York 5-halouracil-modified micrornas and their use in the treatment of cancer
EP4229202A4 (en) * 2020-10-13 2025-10-01 Brigham & Womens Hospital Inc COMPOSITIONS AND METHODS TARGETING CIRC2082 FOR THE TREATMENT OF CANCER

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WO2001091699A2 (en) * 2000-05-30 2001-12-06 Advanced Research & Technology Institute Compositions and methods for identifying agents which modulate pten function and pi-3 kinase pathways
US20110150868A1 (en) * 2003-11-05 2011-06-23 Board Of Regents Of The University Of Texas System Diagnostic and therapeutic methods and compositions involving pten and breast cancer
WO2005089169A2 (en) * 2004-03-12 2005-09-29 Exelixis, Inc. Mptens as modifiers of the pten pathway and methods of use

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Publication number Priority date Publication date Assignee Title
CN105063196B (zh) * 2015-08-03 2018-08-28 中国人民解放军第二军医大学 蛋白酶体抑制剂与细胞自噬激活剂联合在胆管癌治疗中的应用

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WO2013173605A8 (en) 2014-11-27
US20150159161A1 (en) 2015-06-11
BR112014028646A2 (pt) 2017-08-15
WO2013173605A1 (en) 2013-11-21
EA201492118A1 (ru) 2015-04-30
EP2850187A1 (en) 2015-03-25
EP2850187A4 (en) 2016-01-20
AU2013262706A1 (en) 2015-01-22
JP2015519057A (ja) 2015-07-09
CA2873776A1 (en) 2013-11-21

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