CN1045701A - The preparation method of medicine applied on urethra - Google Patents
The preparation method of medicine applied on urethra Download PDFInfo
- Publication number
- CN1045701A CN1045701A CN 89107343 CN89107343A CN1045701A CN 1045701 A CN1045701 A CN 1045701A CN 89107343 CN89107343 CN 89107343 CN 89107343 A CN89107343 A CN 89107343A CN 1045701 A CN1045701 A CN 1045701A
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- preparation
- suppository
- iodine
- urethra
- excipient
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Abstract
The present invention relates to the preparation method of a kind of medicine applied on urethra (particularly suppository), the effective ingredient Wei Dian in this dosage form.For example polyvinylpyrrolidone one iodine and pipemidic acid class.The suppository top layer of this dosage form is enclosed with anesthetis.The present invention is used for the treatment of chronic bacterial prostatitis, chlamydia urethritis, female bladder inflammation and vaginitis etc., and its advantage is that medicine can arrive site of action rapidly.Sterilization is fast, the effective percentage height, and patient is easy to use, misery is little.
Description
The present invention relates to a kind of preparation method of medicine applied on urethra, this dosage form can be used for treating chronic bacterial prostatitis and chlamydia urethritis.
At present, it has been well-known method that the dosage form (as suppository) of application rectally or vagina administration is carried the inapparent medicine of oral administering effect, and carry medicine with the dosage form (as suppository) of urethra administration, treat some special disease, then only feasible in theory, do not paid attention to as yet in practice, do not obtain practical application yet by people.Iodine
, for example polyvinylpyrrolidone-iodine (claiming Povidone-Iodine Solution again) is the 2-Pyrrolidone base, the polymer of 1-vinyl and iodine, skeleton symbol are [(C
6H
9NO)
n-X1], it is a kind of high-efficiency low-toxicity antibacterial, has a broad antifungal spectrum, obtained universally acknowledged, at present, solution, aerosol, ointment, vaginal suppository, rectal suppository etc. are made with this medicine by states such as American and Britain, day, moral, but do not see the report that makes medicine applied on urethra, do not see that more with this medicine be the report that principal agent makes the compound recipe medicine applied on urethra.
The object of the present invention is to provide a kind ofly with iodine, for example polyvinylpyrrolidone-iodine is the method that principal agent is produced the compound recipe medicine applied on urethra, is used for the treatment of diseases such as chronic bacterial prostatitis and chlamydia urethritis.
Medicine applied on urethra of the present invention includes effective constituent and excipient, and described active ingredient is an iodine
(iodine and a kind of carrier, chemical compound as polyvinylpyrrolidone) and the pipemidic acid class, described excipient can be the substrate of preparation suppository, mixture as fatty glyceride, also can be the water solublity or the oil liquid-carrier of preparation fluid dosage form, as glycerin gelatine, syrup, Polyethylene Glycol etc.Iodine
And the ratio of excipient can be 1: 7.5-1: between 20,1: 7.5-1: better between 12, and be best with 1: 9.The ratio of pipemidic acid class and excipient is 1: 60-1: between 120, be preferably 1: 90, can be made into suppository or fluid preparation with above-mentioned active ingredient and excipient.Because urethra is narrower, the shape of described suppository is that front end is conical cylinder, and the diameter of cylindrical section is about 4-6mm, and the ratio of diameter and length is about 1: 4-1: between 8.For easy to use, the outer surface of described suppository can wrap up one deck anesthetis.Its preparation method is that anesthetis (for example lignocaine) solution is poured in the mould earlier, and then will contain the fused excipient impouring mould of active ingredient, treats to solidify fully the back taking-up and gets final product.Also can make suppository earlier, again with suppository surface dipping anesthetis (as lignocaine) solution.Described fluid preparation is active ingredient is dispersed in the liquid-carrier and makes, and fluid preparation can be floating with agent, ointment, solution, gel etc., and these preparations are to be contained in the syringe, or is contained in the pipe and uses.
Advantage of the present invention is that the medicine antibacterial spectrum is wide, sterilization is rapid, the pathogenic bacteria that can resist Chang Bianhuan effectively, and medicine can arrive site of action rapidly, and medicine-feeding way is reasonable, the effective percentage height, patient is easy to use, and is painful little.With urethral suppository treatment chronic bacterial prostatitis of the present invention, effective percentage is treated chlamydia urethritis up to 92.6%, and effective percentage reaches 82%, compares with other Therapeutic Method, has advantages such as evident in efficacy, easy to use.The present invention also can be used for treating female bladder inflammation and vaginitis etc.
Accompanying drawing is the outline drawing of urethral suppository of the present invention.
Embodiment 1: the preparation method of urethral suppository.Every piece of urethral suppository contains effective composition polyvinylpyrrolidone-iodine 50mg, norfloxacin 5mg, anesthetis lignocaine 10mg and excipient fatty glyceride mixt 445mg.Make excipient warm (45-65 ℃) fusion, to stir in effective ingredient polyvinylpyrrolidone-iodine adding excipient, adding norfloxacin again stirs, in mould, pour lignocaine solution earlier into, to contain again in the fused excipient impouring mould of effective ingredient, and treat to solidify fully the back removal and overflow part, opening mold, suppository is released, and packing gets final product.The urethral suppository diameter that makes is φ 4.75mm, and length is 40mm.During use, by taking out suppository in the packing, per urethram collar extension is put into, and it is pushed into prostate peristome behind the pubis, instantly through 4-8 hour separates absorption.
Embodiment 2: the preparation method of the fluid preparation of urethra administration.Effective ingredient is polyvinylpyrrolidone-iodine and pipemidic acid, and the simple syrup that with proportion is 1.0-1.2 is as liquid-carrier.The fluid preparation of every 100ml contains 5g polyvinylpyrrolidone-iodine and 1g pipemidic acid.The preparation that makes can be contained in the syringe or in the pipe and use.
Claims (7)
1, uses known technical method preparation: the method for medicine applied on urethra, this dosage form includes effective constituent and excipient, described excipient can be the substrate of preparation suppository, also can be the oil or water-soluble liquid carrier of preparation fluid dosage form, it is characterized in that described effective ingredient is an iodine
With pipemidic acid class, iodine
And the ratio of excipient is 1: 7.5-1: between 20, the ratio of pipemidic acid class and excipient is 1: 60-1: between 120.
2, the preparation method of medicine applied on urethra according to claim 1 is characterized in that described iodine
Be polyvinylpyrrolidone-iodine.
3, the preparation method of medicine applied on urethra according to claim 1 and 2, it is characterized in that described dosage form is a suppository, the front end that is shaped as of this suppository is conical cylinder, and the diameter of its cylindrical section is about 4-6mm, and the ratio of its diameter and length is about 1: 4-1: 8.
4, the preparation method of medicine applied on urethra according to claim 3 is characterized in that described suppository is coated with anesthetis.
5, the preparation method of medicine applied on urethra according to claim 4 is characterized in that described anesthetis is lignocaine.
6, the preparation method of medicine applied on urethra according to claim 5 is characterized in that every piece of urethral suppository contains polyvinylpyrrolidone-iodine 50mg, norfloxacin 5mg, the mixture 445mg of fatty glyceride, lignocaine 10mg.
7, the preparation method of medicine applied on urethra according to claim 1, the ratio that it is characterized in that described iodine and excipient is 1: 7.5-1: better between 12.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 89107343 CN1030687C (en) | 1989-11-17 | 1989-11-17 | Preparation of medicine applied on urethra |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 89107343 CN1030687C (en) | 1989-11-17 | 1989-11-17 | Preparation of medicine applied on urethra |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1045701A true CN1045701A (en) | 1990-10-03 |
| CN1030687C CN1030687C (en) | 1996-01-17 |
Family
ID=4857173
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 89107343 Expired - Fee Related CN1030687C (en) | 1989-11-17 | 1989-11-17 | Preparation of medicine applied on urethra |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1030687C (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001017479A3 (en) * | 1999-09-09 | 2001-09-20 | Androsolutions Inc | Methods and compositions for preventing and treating prostate disorders |
| KR100494277B1 (en) * | 1996-05-17 | 2005-08-05 | 에드코 트래이딩 앤드 레프리젠테이션 캄파니 리미티드 | Anti-Vaginitis Composition for Topical Use Comprising One or More Anti-Vaginitis Medicaments and One or More Local Anaesthetics |
| CN100358537C (en) * | 2002-07-16 | 2008-01-02 | 黑龙江成功药业有限公司 | Compound povidone iodine external use medicine |
| CN107920510A (en) * | 2015-08-24 | 2018-04-17 | 史密夫和内修有限公司 | Synergistic antimicrobial activity of the combination of middle polarity oil and antiseptic in bacterial biof iotalm |
-
1989
- 1989-11-17 CN CN 89107343 patent/CN1030687C/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100494277B1 (en) * | 1996-05-17 | 2005-08-05 | 에드코 트래이딩 앤드 레프리젠테이션 캄파니 리미티드 | Anti-Vaginitis Composition for Topical Use Comprising One or More Anti-Vaginitis Medicaments and One or More Local Anaesthetics |
| WO2001017479A3 (en) * | 1999-09-09 | 2001-09-20 | Androsolutions Inc | Methods and compositions for preventing and treating prostate disorders |
| WO2001017480A3 (en) * | 1999-09-09 | 2001-11-01 | Androsolutions Inc | Methods and compositions for preventing and treating urinary tract disorders |
| CN100358537C (en) * | 2002-07-16 | 2008-01-02 | 黑龙江成功药业有限公司 | Compound povidone iodine external use medicine |
| CN107920510A (en) * | 2015-08-24 | 2018-04-17 | 史密夫和内修有限公司 | Synergistic antimicrobial activity of the combination of middle polarity oil and antiseptic in bacterial biof iotalm |
| US11197476B2 (en) | 2015-08-24 | 2021-12-14 | Smith & Nephew, Inc. | Synergistic antibacterial activity of medium polarity oils in combination with antibacterial agents on bacterial biofilms |
| US11641856B2 (en) | 2015-08-24 | 2023-05-09 | Smith & Nephew, Inc. | Synergistic antibacterial activity of medium polarity oils in combination with antibacterial agents on bacterial biofilms |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1030687C (en) | 1996-01-17 |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |