CN104055734A - Traditional Chinese medicinal composition for treating vaginitis and preparation method of foam aerosol thereof - Google Patents
Traditional Chinese medicinal composition for treating vaginitis and preparation method of foam aerosol thereof Download PDFInfo
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Abstract
A traditional Chinese medicinal composition for treating vaginitis consists of the following components by weight: 2-10% of fibrauretine, 2-15% of rhizoma bletillae polysaccharide, 5-10% of glycerine or propylene glycol, 0.5-5% of a foaming agent, 0.01-0.5% of a natural preservative and 59.5-90.49% purified water, wherein the total weight percentage of the components is 100%. The invention also discloses a preparation method of a foam aerosol of the composition. The method is as below: mixing fibrauretine and the foaming agent, adding the mixture to the purified water to obtain a medicinal soup 1; dispersing the rhizoma bletillae polysaccharide in glycerine or propylene glycol, and adding the mixture to medicinal soup 1 to obtain a medicinal soup 2; sterilizing the medicinal soup 2, adding the natural preservative, encapsulating the mixture in an overpressure resistant container, cooling to room temperature and adding a propellant to obtain the foam aerosol. The fibrauretine with the slow expansion and deformation of foams in the vagina spreads and distributes evenly in the vagina, and adheres to vaginal mucosa for a long time under the biological adhesion effect of bletilla polysaccharide gel fluid, so as to prolong the retention time.
Description
Technical field
The invention belongs to medical technical field, be specifically related to one and be used for the treatment of colpitic Chinese medicine composition, the invention still further relates to the preparation method of this Chinese medicine composition foam aerosol.
Background technology
Female genital disease is a kind of commonly encountered diseases and frequently-occurring disease, and each age level all can occur.Female genital disease is because pathogenic infection microorganism comprises the inflammation that gonorrhea diplococcus, mycete, infusorian etc. cause; Its incidence rate reaches more than 65%, and women of child-bearing age's sickness rate has exceeded 70%.Female genital disease can cause pelvic inflammatory disease, infertile, premature labor, infection of newborn etc., even can cause cervical carcinogenesis because repeated infection stimulates, therefore, very harmful, also brings huge psychology and physiological injury to patient.Clinically, the primary treatment method of female genital disease has oral administration and vagina administration.Wherein, vagina administration has and can avoid the first pass effect of oral administration and the untoward reaction that blood drug level peak valley phenomenon causes; Can avoid medicine to stimulate and lesions of liver and kidney for gastrointestinal; Local targeting is strong, and bioavailability is high; Medicine efficient transmission can also be delivered to advantages such as " the first uterus transmission effects " of uterus blood circulation and become the characteristic route of administration in gynaecopathia field, becoming in recent years the focus of research.
Fibrauretin (palmatine) is to extract a kind of alkaloids natural plant refining and that obtain from the dry rattan of menispermaceous plants Caulis Fibraureae (FibraurearecisaPierre), there is broad-spectrum antibacterial action, multiple gram positive bacteria and gram negative bacteria are all had to significant inhibitory action; There is the activity of higher anti-trichomonal vaginitis; Can also strengthen the effect of leukocytes phagocytic ability.Therefore, the clinical treatment that is mainly used in the diseases such as gynecological inflammation, urinary tract infection and surgical infection.The main dosage form of fibrauretin external is tablet, capsule, lotion, suppository and gel, and the general character difficult point that these dosage forms face is that medicine is difficult to sprawl and is evenly distributed or the time is detained shortly in vagina cavity, has therefore weakened the therapeutic effect of medicine.Due to the soft comfortableness of gel and bioadhesive is good and patient is easy to accept gel, but an outstanding shortcoming of gel is gel because viscosity is compared with high and be difficult to sprawl in vagina cavity and be evenly distributed; And common aerosol, although can make medicine farthest distribute in vagina cavity, time of contact of causing medicine and focus because its bioadhesive is poor of short duration and unsatisfactory curative effect.
Summary of the invention
The object of this invention is to provide one and be used for the treatment of colpitic Chinese medicine composition, solved existing gel in vagina cavity, be difficult to sprawl be evenly distributed and the bioadhesive of aerosol poor and cause the of short duration and problem of unsatisfactory curative effect time of contact of medicine and focus.
Another object of the present invention is to provide a kind of preparation method that is used for the treatment of colpitic Chinese medicine composition foam aerosol.
The technical solution adopted in the present invention is, be used for the treatment of colpitic Chinese medicine composition, according to percentage by weight, composed of the following components: fibrauretin 2.00～10.00%, bletilla polysaccharide 2.00～15.00%, glycerol or propylene glycol 5.00～10.00%, foaming agent 0.50～5.00%, natural antiseptic agent 0.01～0.5%, purified water 59.50～90.49%, the percentage by weight sum of each component is 100%.
Feature of the present invention is also,
Foaming agent is wherein any one of sodium lauryl sulphate, PLURONICS F87, Tween-80, lauroyl CAB, lauryl alcohol sulfuric ester ammonium salt.
Natural antiseptic agent is wherein any one of eucalyptus oil, cinnamic aldehyde, Oleum Caryophylli, Oleum menthae, oil of Herba Pogostemonis.
Another technical scheme of the present invention is, is used for the treatment of the preparation method of colpitic Chinese medicine composition foam aerosol, and concrete steps comprise:
Step 1, take respectively fibrauretin 2.00～10.00% according to percentage by weight, bletilla polysaccharide 2.00～15.00%, glycerol or propylene glycol 5.00～10.00%, foaming agent 0.50～5.00%, natural antiseptic agent 0.01～0.5%, purified water 59.50～90.49%, the percentage by weight sum of each component is 100%;
Step 2, the fibrauretin that step 1 is taken mixes with foaming agent, joins in purified water, is stirred to abundant dissolving, obtains medicinal liquid-1, for subsequent use;
Step 3, is scattered in bletilla polysaccharide in glycerol or propylene glycol, mix homogeneously, more slowly join in step 2 gained medicinal liquid-1, be stirred to bletilla polysaccharide and fully dissolve, obtain medicinal liquid-2, for subsequent use;
Step 4, by step 3 gained medicinal liquid-2 in 80～100 DEG C of sterilizings 1 hour, in the time that fluid temperature is down to 40 DEG C～50 DEG C, add natural antiseptic agent, mix homogeneously, uses the purified water of sterilizing to adjust cumulative volume to 1000ml, embedding is in pressure vessel again, semi-finished product aerosol good fill is put to room temperature, and then every bottle adds propellant, to obtain final product.
Feature of the present invention is also,
In step 1, foaming agent is wherein any one of sodium lauryl sulphate, PLURONICS F87, Tween-80, lauroyl CAB, lauryl alcohol sulfuric ester ammonium salt.
In step 1, natural antiseptic agent can be wherein any one of eucalyptus oil, cinnamic aldehyde, Oleum Caryophylli, Oleum menthae, oil of Herba Pogostemonis.
In step 4, propellant is wherein any one of hydrofluoroalkane hydro carbons or hydrocarbon or dimethyl ether.
The invention has the beneficial effects as follows,
1. the present invention is used for the treatment of colpitic Chinese medicine composition, taking bletilla polysaccharide as preparing macromolecular material and the bio-adhesive material of hydrogel, avoid existing in synthesized polymer material organic solvent and monomer residue and may cause the drawback of side effect, in addition bletilla polysaccharide has the pharmacologically actives such as antiulcer, antiinflammatory, hemostasis, can bring into play synergism with fibrauretin, improve curative effect.
2. the present invention is used for the treatment of the preparation method of colpitic Chinese medicine composition foam aerosol, the Chinese medicine composition foam aerosol preparing, when administration, fibrauretin can make to sprawl in intravaginal along with the slow expansion of foam and metamorphosis and be evenly distributed in vagina cavity, and with vaginal wall close contact; There is long-time adhesion with vaginal mucosa in fibrauretin, extended the holdup time under the bio-adhesive effect of bletilla polysaccharide coagulant liquid.
3. the vagina administration preparation that the present invention is fibrauretin, easy to use, local targeting is strong, has avoided first-pass effect that oral Preparation has and the drawback in stimulating gastrointestinal road.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the present invention is described in detail.
The present invention is used for the treatment of colpitic Chinese medicine composition, according to percentage by weight, composed of the following components: fibrauretin 2.00～10.00%, bletilla polysaccharide 2.00～15.00%, glycerol or propylene glycol 5.00～10.00%, foaming agent 0.50～5.00%, natural antiseptic agent 0.01～0.5%, purified water 59.50～90.49%, the percentage by weight sum of each component is 100%.
Foaming agent is wherein any one of sodium lauryl sulphate, PLURONICS F87, Tween-80, lauroyl CAB, lauryl alcohol sulfuric ester ammonium salt.
Natural antiseptic agent can be wherein any one of eucalyptus oil, cinnamic aldehyde, Oleum Caryophylli, Oleum menthae, oil of Herba Pogostemonis.
The above-mentioned preparation method that is used for the treatment of colpitic Chinese medicine composition foam aerosol, concrete steps comprise:
Step 1, take respectively fibrauretin 2.00～10.00% according to percentage by weight, bletilla polysaccharide 2.00～15.00%, glycerol or propylene glycol 5.00～10.00%, foaming agent 0.50～5.00%, natural antiseptic agent 0.01～0.5%, purified water 59.50～90.49%, the percentage by weight sum of each component is 100%;
Step 2, the fibrauretin that step 1 is taken mixes with foaming agent, joins in purified water, is stirred to abundant dissolving, obtains medicinal liquid-1, for subsequent use;
Step 3, is scattered in bletilla polysaccharide in glycerol or propylene glycol, mix homogeneously, more slowly join in step 2 gained medicinal liquid-1, be stirred to bletilla polysaccharide and fully dissolve, obtain medicinal liquid-2, for subsequent use;
Step 4, by step 3 gained medicinal liquid-2 in 80～100 DEG C of sterilizings 1 hour, in the time that fluid temperature is down to 40 DEG C～50 DEG C, add natural antiseptic agent, mix homogeneously, uses the purified water of sterilizing to adjust cumulative volume to 1000ml, embedding is in pressure vessel again, semi-finished product aerosol good fill is put to room temperature, and then every bottle adds propellant, to obtain final product.
Wherein propellant is wherein any one of hydrofluoroalkane hydro carbons or hydrocarbon or dimethyl ether.
Key point of the present invention place is described from principle aspect below:
The medicine that the present invention faces according to vagina administration regular dosage form is difficult to sprawl and is evenly distributed or the time is detained short general character difficult point in vagina cavity, used for reference the feature of hydrogel adhesive, aerosol and foam, and to adopt bletilla polysaccharide be the fibrauretin aquogel type foam aerosol that hydrogel adjuvant is prepared from through modern preparation technique.When administration of the present invention, fibrauretin can make to sprawl in intravaginal along with the slow expansion of foam and metamorphosis and be evenly distributed in vagina cavity, and with vaginal wall close contact; There is long-time adhesion with vaginal mucosa in fibrauretin, extended the holdup time under the bio-adhesive effect of bletilla polysaccharide coagulant liquid.The present invention provides a kind of novel form for the application of fibrauretin in clinical, and provides a kind of new technological means for the treatment of female genital disease.
1. the fibrauretin that the present invention adopts is a kind of alkaloid extracting the Fibraurea Tinctoria from having heat-clearing and toxic substances removing, dampness removing effect, has the activity of broad-spectrum antibacterial action and higher anti-trichomonal vaginitis, can also strengthen the effect of leukocytes phagocytic ability.Pseudobulbus Bletillae (Rhizoma Bletillae) has the effects such as convergence granulation promoting, clearing away heat-damp and promoting diuresis, detumescence and promoting granulation, bletilla polysaccharide is the degradable polysaccharide component of one extracting from Bletilla striata, there is the pharmacologically active widely such as antiulcer, antiinflammatory, hemostasis, and nontoxic to human-body safety, water-soluble rear formation has the hydrogel of good biological adhesion, widely as medical material and cosmetics adjuvant, in the present invention as adjuvant and the bio-adhesive material of preparing hydrogel matrix.Therefore, between fibrauretin and bletilla polysaccharide, there is synergism, can be better for the treatment of female genital disease.
2. the preparation process that the present invention is used for the treatment of colpitic Chinese medicine composition foam aerosol has adopted and skin mucosa has been had to the glycerol or the propylene glycol that nourish moistening effect, adopt natural plant essential oils as antiseptic, thereby ensured that product safety of the present invention is nontoxic, comfortable non-stimulated.
Embodiment 1
Step 1, takes respectively fibrauretin 20g, bletilla polysaccharide 150g, and propylene glycol 50g, sodium lauryl sulphate 5g, Oleum menthae 5g, purified water 770g, the percentage by weight sum of each component is 100%;
Step 2, mixes fibrauretin with sodium lauryl sulphate, join in purified water, is stirred to abundant dissolving, obtains medicinal liquid-1, for subsequent use;
Step 3, is scattered in bletilla polysaccharide in propylene glycol, mix homogeneously, more slowly join in step 2 gained medicinal liquid-1, be stirred to bletilla polysaccharide and fully dissolve, obtain medicinal liquid-2, for subsequent use;
Step 4, by step 3 gained medicinal liquid-2 in 100 DEG C of sterilizings 1 hour, in the time that fluid temperature is down to 40 DEG C, add Oleum menthae, mix homogeneously, uses the purified water of sterilizing to adjust cumulative volume to 1000ml, embedding is in pressure vessel again, semi-finished product aerosol good fill is put to room temperature, and then every bottle adds the hydrofluoroalkane hydro carbons propellant HFA-134a of content gross weight 8%, to obtain final product.
Embodiment 2
Step 1, takes respectively fibrauretin 100g, bletilla polysaccharide 20g, and glycerol 100g, PLURONICS F87 50g, cinnamic aldehyde 0.1g, purified water 729.9g, the percentage by weight sum of each component is 100%;
Step 2, mixes fibrauretin with PLURONICS F87, join in purified water, is stirred to abundant dissolving, obtains medicinal liquid-1, for subsequent use;
Step 3, is scattered in bletilla polysaccharide in glycerol, mix homogeneously, more slowly join in step 2 gained medicinal liquid-1, be stirred to bletilla polysaccharide and fully dissolve, obtain medicinal liquid-2, for subsequent use;
Step 4, by step 3 gained medicinal liquid-2 in 100 DEG C of sterilizings 1 hour, in the time that fluid temperature is down to 40 DEG C, add cinnamic aldehyde, mix homogeneously, uses the purified water of sterilizing to adjust cumulative volume to 1000ml, embedding is in pressure vessel again, semi-finished product aerosol good fill is put to room temperature, and then every bottle adds the hydrofluoroalkane hydro carbons propellant HFA-227 of content gross weight 8%, to obtain final product.
Embodiment 3
Step 1, takes respectively fibrauretin 60g, bletilla polysaccharide 70g, and glycerol 50g, lauroyl CAB 30g, eucalyptus oil 1g, purified water 789g, the percentage by weight sum of each component is 100%;
Step 2, mixes fibrauretin with lauroyl CAB, join in purified water, is stirred to abundant dissolving, obtains medicinal liquid-1, for subsequent use;
Step 3, is scattered in bletilla polysaccharide in glycerol, mix homogeneously, more slowly join in step 2 gained medicinal liquid-1, be stirred to bletilla polysaccharide and fully dissolve, obtain medicinal liquid-2, for subsequent use;
Step 4, by step 3 gained medicinal liquid-2 in 100 DEG C of sterilizings 1 hour, in the time that fluid temperature is down to 50 DEG C, add eucalyptus oil, mix homogeneously, uses the purified water of sterilizing to adjust cumulative volume to 1000ml, embedding is in pressure vessel again, semi-finished product aerosol good fill is put to room temperature, and then every bottle adds hydrocarbon propellant propane and the iso-butane mixture (mass ratio 30:70) of content gross weight 6%, to obtain final product.
Embodiment 4
Step 1, takes respectively fibrauretin 50g, bletilla polysaccharide 90g, and propylene glycol 70g, lauryl alcohol sulfuric ester ammonium salt 5g, Oleum Caryophylli 1g, purified water 784g, the percentage by weight sum of each component is 100%;
Step 2, mixes fibrauretin with lauryl alcohol sulfuric ester ammonium salt, join in purified water, is stirred to abundant dissolving, obtains medicinal liquid-1, for subsequent use;
Step 3, by bletilla polysaccharide, is scattered in propylene glycol, mix homogeneously, more slowly join in step 2 gained medicinal liquid-1, be stirred to bletilla polysaccharide and fully dissolve, obtain medicinal liquid-2, for subsequent use;
Step 4, by step 3 gained medicinal liquid-2 in 100 DEG C of sterilizings 1 hour, in the time that fluid temperature is down to 48 DEG C, add Oleum Caryophylli, mix homogeneously, uses the purified water of sterilizing to adjust cumulative volume to 1000ml, embedding is in pressure vessel again, semi-finished product aerosol good fill is put to room temperature, and then every bottle adds the dimethyl ether propellant of content gross weight 7%, to obtain final product.
Embodiment 5
Step 1, takes respectively fibrauretin 80g, bletilla polysaccharide 50g, and glycerol 60g, Tween-80 50g, oil of Herba Pogostemonis 5g, purified water 755g, the percentage by weight sum of each component is 100%;
Step 2, mixes fibrauretin with Tween-80, join in purified water, is stirred to abundant dissolving, obtains medicinal liquid-1, for subsequent use;
Step 3, by bletilla polysaccharide, is scattered in glycerol, mix homogeneously, more slowly join in step 2 gained medicinal liquid-1, be stirred to bletilla polysaccharide and fully dissolve, obtain medicinal liquid-2, for subsequent use;
Step 4, by step 3 gained medicinal liquid-2 in 100 DEG C of sterilizings 1 hour, in the time that fluid temperature is down to 50 DEG C, add oil of Herba Pogostemonis, mix homogeneously, uses the purified water of sterilizing to adjust cumulative volume to 1000ml, embedding is in pressure vessel again, semi-finished product aerosol good fill is put to room temperature, and then every bottle adds the hydrofluoroalkane hydro carbons propellant HFA-134a of content gross weight 10%, to obtain final product.
Embodiment 6
Step 1, takes respectively fibrauretin 100g, bletilla polysaccharide 150g, and propylene glycol 100g, sodium lauryl sulphate 50g, Oleum menthae 5g, purified water 595g, the percentage by weight sum of each component is 100%;
Step 2, mixes fibrauretin with sodium lauryl sulphate, join in purified water, is stirred to abundant dissolving, obtains medicinal liquid-1, for subsequent use;
Step 3, is scattered in bletilla polysaccharide in propylene glycol, mix homogeneously, more slowly join in step 2 gained medicinal liquid-1, be stirred to bletilla polysaccharide and fully dissolve, obtain medicinal liquid-2, for subsequent use;
Step 4, by step 3 gained medicinal liquid-2 in 100 DEG C of sterilizings 1 hour, in the time that fluid temperature is down to 40 DEG C, add Oleum menthae, mix homogeneously, uses the purified water of sterilizing to adjust cumulative volume to 1000ml, embedding is in pressure vessel again, semi-finished product aerosol good fill is put to room temperature, and then every bottle adds the hydrofluoroalkane hydro carbons propellant HFA-134a of content gross weight 8%, to obtain final product.
Embodiment 7
Step 1, takes respectively fibrauretin 20g, bletilla polysaccharide 20g, and glycerol 50g, PLURONICS F87 5g, cinnamic aldehyde 0.1g, purified water 904.9g, the percentage by weight sum of each component is 100%;
Step 2, mixes fibrauretin with PLURONICS F87, join in purified water, is stirred to abundant dissolving, obtains medicinal liquid-1, for subsequent use;
Step 3, is scattered in bletilla polysaccharide in glycerol, mix homogeneously, more slowly join in step 2 gained medicinal liquid-1, be stirred to bletilla polysaccharide and fully dissolve, obtain medicinal liquid-2, for subsequent use;
Step 4, by step 3 gained medicinal liquid-2 in 100 DEG C of sterilizings 1 hour, in the time that fluid temperature is down to 40 DEG C, add cinnamic aldehyde, mix homogeneously, uses the purified water of sterilizing to adjust cumulative volume to 1000ml, embedding is in pressure vessel again, semi-finished product aerosol good fill is put to room temperature, and then every bottle adds the hydrofluoroalkane hydro carbons propellant HFA-227 of content gross weight 8%, to obtain final product.
Further illustrate from clinical practice result the beneficial effect that the present invention produces below:
1. case selection:
Add up 30 routine married female patients, 25～45 years old age; Patient did not all use antibiotics in 1 month, was mainly the inflammation that pure vulvitis, colpitis mycotica, trichomonacide etc. cause, showed as pruritus, pudendum redness, scorching hot pain, difficulty and pain in micturition etc.
2. Therapeutic Method:
Intravaginal administration group (15 people): large delivery catheter end is slowly inserted in vaginal canal, and the pressure valve that press...withes one's finger, until foam is full of after vagina (foam volume is advisable not overflow vaginal orifice), slowly exits conduit.Administration every day 1 time 7 days is 1 course for the treatment of.
Pudendum medication group (15 people): it is appropriate to get this product, is directly coated with and puts on the skin in affected part, after 3-5 minute, cleans with clear water.Administration every day 2 times 7 days is 1 course for the treatment of.
3. curative effect judging standard:
Taking symptom improvement degree as curative effect determinate standard, be divided into recovery from illness, effective, invalid 3 kinds.Recovery from illness: medication is after 7 days, and subjective symptoms and sign disappear completely, pathogen feminine gender; Effective: medication is after 7 days, and subjective symptoms and sign part disappear, pathogen feminine gender; Invalid: medication is after 7 days, subjective symptoms and sign be without change, the pathogen positive.
4. therapeutic outcome:
Intravaginal administration group, 15 routine patients, after treating 1 course for the treatment of, cure 12 examples, account for 80.00%; Effective 3 examples, account for 20.00%; Total effective rate is 100%.
Pudendum medication group, 15 routine patients, after treating 1 course for the treatment of, cure 9 examples, account for 60.00%; Effective 4 examples, account for 26.67%; Invalid 2 examples, account for 13.33%; Total effective rate is 86.67%.
In therapeutic process, patient reflects that product of the present invention is easy to use, comfortable, without any pessimal stimulation.
Claims (7)
1. be used for the treatment of colpitic Chinese medicine composition, it is characterized in that, according to percentage by weight, composed of the following components: fibrauretin 2.00～10.00%, bletilla polysaccharide 2.00～15.00%, glycerol or propylene glycol 5.00～10.00%, foaming agent 0.50～5.00%, natural antiseptic agent 0.01～0.5%, purified water 59.50～90.49%, the percentage by weight sum of each component is 100%.
2. be according to claim 1ly used for the treatment of colpitic Chinese medicine composition, it is characterized in that, described foaming agent is wherein any one of sodium lauryl sulphate, PLURONICS F87, Tween-80, lauroyl CAB, lauryl alcohol sulfuric ester ammonium salt.
3. be according to claim 1 and 2ly used for the treatment of colpitic Chinese medicine composition, it is characterized in that, described natural antiseptic agent is wherein any one of eucalyptus oil, cinnamic aldehyde, Oleum Caryophylli, Oleum menthae, oil of Herba Pogostemonis.
4. the preparation method that is used for the treatment of colpitic Chinese medicine composition foam aerosol according to claim 1, is characterized in that, concrete steps comprise:
Step 1, take respectively fibrauretin 2.00～10.00% according to percentage by weight, bletilla polysaccharide 2.00～15.00%, glycerol or propylene glycol 5.00～10.00%, foaming agent 0.50～5.00%, natural antiseptic agent 0.01～0.5%, purified water 59.50～90.49%, the percentage by weight sum of each component is 100%;
Step 2, the fibrauretin that step 1 is taken mixes with foaming agent, joins in purified water, is stirred to abundant dissolving, obtains medicinal liquid-1, for subsequent use;
Step 3, is scattered in bletilla polysaccharide in glycerol or propylene glycol, mix homogeneously, more slowly join in step 2 gained medicinal liquid-1, be stirred to bletilla polysaccharide and fully dissolve, obtain medicinal liquid-2, for subsequent use;
Step 4, by step 3 gained medicinal liquid-2 in 80～100 DEG C of sterilizings 1 hour, in the time that fluid temperature is down to 40 DEG C～50 DEG C, add natural antiseptic agent, mix homogeneously, uses the purified water of sterilizing to adjust cumulative volume to 1000ml, embedding is in pressure vessel again, semi-finished product aerosol good fill is put to room temperature, and then every bottle adds propellant, to obtain final product.
5. the preparation method that is used for the treatment of colpitic Chinese medicine composition foam aerosol according to claim 4, it is characterized in that, in step 1, foaming agent is wherein any one of sodium lauryl sulphate, PLURONICS F87, Tween-80, lauroyl CAB, lauryl alcohol sulfuric ester ammonium salt.
6. the preparation method that is used for the treatment of colpitic Chinese medicine composition foam aerosol according to claim 4, is characterized in that, in step 1, natural antiseptic agent can be wherein any one of eucalyptus oil, cinnamic aldehyde, Oleum Caryophylli, Oleum menthae, oil of Herba Pogostemonis.
7. the preparation method that is used for the treatment of colpitic Chinese medicine composition foam aerosol according to claim 4, is characterized in that, in step 4, propellant is wherein any one of hydrofluoroalkane hydro carbons or hydrocarbon or dimethyl ether.
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Cited By (1)
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| CN107441183A (en) * | 2017-07-05 | 2017-12-08 | 西安医学院 | Treat gel foamable composition of gynaecological imflammation and its preparation method and application |
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| CN1628660A (en) * | 2004-09-06 | 2005-06-22 | 赵远 | Externally used liquid preparation containing fibrauretine and its application on genital tract, oral cavity and upper respiratory tract |
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| CN107441183A (en) * | 2017-07-05 | 2017-12-08 | 西安医学院 | Treat gel foamable composition of gynaecological imflammation and its preparation method and application |
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