CN104568839B - Biosensor based on cascade connection of optical resonant cavity and reflective polarization converter - Google Patents
Biosensor based on cascade connection of optical resonant cavity and reflective polarization converter Download PDFInfo
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- CN104568839B CN104568839B CN201410790916.1A CN201410790916A CN104568839B CN 104568839 B CN104568839 B CN 104568839B CN 201410790916 A CN201410790916 A CN 201410790916A CN 104568839 B CN104568839 B CN 104568839B
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Abstract
The invention discloses a biosensor based on cascade connection of an optical resonant cavity and a reflective polarization converter. The biosensor comprises a broadband light source, a circulator, a detector, the optical resonant cavity and the reflective polarization converter, wherein a first port of the circulator is connected with the broadband light source; a second port of the circulator is connected with an input end of the optical resonant cavity; a third port of the circulator is connected with the detector; an output end of the optical resonant cavity is connected with the reflective polarization converter; and a biological surface membrane with a specific adsorption function is arranged in the optical resonant cavity, and is in contact with a tested liquid. According to the biosensor, a to-be-detected component in the tested liquid is adsorbed by the biological surface membrane, so that the effective refractive indexes of light in two polarization states in the optical resonant cavity are different in change, and resonance peaks in two polarization states are different in movement, so as to generate the vernier effect. Movement of a sensor transmission spectrum envelope is amplified, and is transformed into change of output power; the manufacturing cost of the sensor is reduced; and the temperature sensitivity is greatly removed.
Description
Technical field
The present invention relates to a kind of optical biosensor, more particularly, to one kind are turned with reflective polarizing based on optical resonator
The biosensor of parallel operation cascade.
Background technology
Optical pickocff is biomedical diagnostic, the very promising detection work in the field such as environmental monitoring and food safety
Tool.Optical pickocff has many good qualities：Electromagnetism interference is strong, markless detection and easily prepared optical-elec-tronic integrated chip.Base
In SOI（SOI）Evanescent wave sensor, with its high sensitivity, the features such as integrated level is high and compatible with CMOS technology, enjoys state
The concern of inside and outside researcher.The light wave meeting condition of resonance will be coupled to optical resonance intracavity, and light wave is in the form of evanescent wave
Exponential damping in fluid to be measured.When fluid to be measured changes, the condition of resonance of optical resonator also changes therewith,
Moved by measurement resonance wavelength or the light energy of fixed wave length changes the change obtaining measured matter near resonance wavelength.
How to improve the problem that transducer sensitivity is that researcher is paid close attention to always.Although the optical resonator of high q-factor can
Improve the sensitivity of optical biosensor, however it is necessary that the tunable laser of high-resolution spectrogrph or narrow linewidth,
This all increases the cost of optical biosensor.
Cascade the optical pickocff producing cursor effect using dual resonant cavity, need not high-resolution spectrogrph or narrow line
Wide laser instrument, can substantially reduce the cost of sensor while improving transducer sensitivity.This kind of transducer sensitivity
Exaggerated multiplying power and two optical resonators（Sensing chamber and reference cavity）Free Spectral Range（FSR）Difference be inversely proportional to, so
Construct the sensitivity that two equal optical resonators can obtain maximum.But because sensing chamber top covering is fluid to be measured,
Reference cavity top covering is fixing low-index material, adds the error of the processing technology such as photoetching and etching, in actual applications
It is difficult to prepare two optical resonators with identical FSR, ultimate sensitivity is affected significantly；Additionally, because sensing
Ring is different from the top covering material of reference rings, and thermal coefficient of expansion is different, is therefore difficult to eliminate the impact to sensor characteristics for the temperature.
Content of the invention
It is an object of the invention to provide a kind of biological biography based on optical resonator and the cascade of reflective polarizing transducer
Sensor, is combined using optical resonator and reflective polarizing transducer, is effectively rolled over using optical resonator under two kinds of polarization states
Penetrate the difference of rate change, form cursor effect, spectral detection information is changed into the change of transmission gross output, thus significantly
Reduce the cost of manufacture of optical pickocff；Meanwhile, reference optical resonator cavity and sensing optical resonator cavity are same resonator cavity, solution
The problem of the optical resonator making difficulty with identical FSR of having determined two, can also eliminate the shadow to sensor for the temperature significantly
Ring.
The purpose of the present invention is achieved through the following technical solutions：One kind is based on optical resonator and reflective polarizing
The biosensor of transducer cascade, including the conversion of wideband light source, circulator, detector, optical resonator and reflective polarizing
Device；The first port of described circulator is connected with wideband light source；The second port of described circulator and the input of optical resonator
End connects；3rd port of described circulator is connected with detector；The outfan of described optical resonator and reflective polarizing turn
Parallel operation is connected；Described optical resonator inner waveguide core layer surface has the biological surface film of specific adsorption function；Described optics
The biological surface film of resonator cavity is contacted with fluid to be measured；Described reflective polarizing transducer includes polarization converter and reflecting mirror.
Further, by adjusting the thickness of biological surface film, realize described optical resonator for TE and TM pattern two
The effective refractive index of kind polarized light is identical so that described optical resonator is for all resonant frequencies of TE pattern and for TM mould
All resonant frequencies of formula overlap.
Further, the specific adsorption to test substance in fluid to be measured for the described optical resonance intracavity biological surface film,
The TM pattern effective refractive index causing described optical resonator changes acutely, but the change of TE pattern effective refractive index slow so that
When a resonant frequency for TE pattern for the described optical resonator is overlapped with a resonant frequency for TM pattern, other phases
Adjacent resonance peak not exclusively overlaps, thus producing cursor effect.
Further, described optical resonator has periodic filtering characteristic, such as Fabry pool sieve chamber or annular resonance
Chamber.
Further, described optical resonator can adopt Planar integration fiber waveguide, or discrete optical element, or optical fiber
Constitute.
The invention has the advantages that：The present invention is wideband light source using input light source, reduces sensor cost；Light
Learn resonator cavity and can adopt integrated optical wave guide device, make sensor bulk less, more portable, it is easy to accomplish high flux, multiparameter
Measurement；Using bionical molecular modification technology, the biological surface film being modified with specific adsorption function in optical resonance intracavity makes biography
Sensor has specific detection function；Change different when being changed with measured matter using the effective refractive index of two kinds of polarization state lights,
Only just can form cursor effect with single optical resonator, while raising sensor integration is spent, reduce use cost；No
There is reference cavity different with sensing resonator cavity top covering material thermal expansion coefficient, and the temperature sensitive properties leading to；Pass through
Adjustment biomolecule modifies film thickness, and the effective refractive index easily realizing two resonator cavitys under TE with TM pattern is identical,
Thus significantly improving the sensitivity of sensor.
Brief description
Fig. 1 is a kind of biosensor schematic diagram based on optical resonator and the cascade of reflective polarizing transducer；
Fig. 2 is the end view of optical resonator in optical biosensor；
Fig. 3 is the output spectrum curve synoptic diagram of wideband light source；
Fig. 4 is for waveguide effective index under TE and TM pattern with biological surface film thickness change curve synoptic diagram；
Fig. 5 adsorbs before and after's sensor total output spectrum schematic diagram for measured matter；
Fig. 6 receives luminous power and biological surface film thickness change relation schematic diagram for detector；
In figure, wideband light source 1, circulator 2, detector 3, optical resonator 4, reflective polarizing transducer 5, circulator 2
First port 21, the second port 22 of circulator 2, the input 41 of optical resonator 4, the 3rd port 23 of circulator 2, light
The outfan 42 of resonator cavity 4, polarization converter 51, reflecting mirror 52, optical resonator 4 inner waveguide sandwich layer 81, biological surface film
6th, the under-clad layer 82 of fluid to be measured 7, waveguide core layer.
Specific embodiment
The present invention is further illustrated with reference to the accompanying drawings and examples.
Embodiment
As shown in figure 1, the present invention is a kind of being passed based on the optical bio of optical resonator and the cascade of reflective polarizing transducer
Sensor, including wideband light source 1, circulator 2, detector 3, optical resonator 4 and reflective polarizing transducer 5；The of circulator 2
Single port 21 is connected with wideband light source 1；The second port 22 of described circulator 2 is connected with the input 41 of optical resonator 4；Institute
The 3rd port 23 stating circulator 2 is connected with detector 3；The outfan 42 of described optical resonator 4 and reflective polarizing conversion
Device 5 is connected；Described reflective polarizing transducer 5 includes polarization converter 51 and reflecting mirror 52.
As shown in Fig. 2 there is the biological surface film of specific adsorption function on described optical resonator 4 inner waveguide sandwich layer 81 surface
6；The biological surface film 6 of described optical resonator is contacted with fluid to be measured 7；The under-clad layer 82 of waveguide core layer is low-refraction material
Material.
The light that wideband light source 1 sends passes through a port 21 of circulator 2, enters from second port 22 of circulator 2
Enter optical resonator 4, after a kind of light of polarization mode is acted on biological surface film 6, after reflection type polarization converter 5 reflection again
Secondary entrance optical resonator 4, the light of another polarization mode acted on again with biological surface film 6, finally from the of circulator 2
Three ports 23 export in detector 3.
As shown in figure 3, the output spectrum of described wideband light source 1, centre wavelength is near 1555nm.Select flat in this example
Ring resonator in the integrated light guide of face is as the optical resonator of sensor.Design alternative SOI（silicon-on-
insulator）Material, waveguide core layer 81 height 250nm, width 240m, core refractive rate 3.48, under-clad layer 82 refractive index
1.444, the refractive index 1.52 of biological surface film 6, the refractive index 1.33 of testing liquid, the radius of ring resonator is 13 μm.Partially
The transducer 51 that shakes is made using magneto-optical crystal materials.TE with TM pattern represents that the direction of vibration of electric field is parallel and vertical respectively
Interface in biological surface film 6 and waveguide core layer 81.
As shown in figure 4, adjusting the thickness of biological surface film 6 with bionical molecular modification technology, when thickness is in 27nm（Just
Beginning state）, TE and TM have identical effective refractive index.Optical resonator transmission spectrum under two polarization modes overlaps, because
The luminous power that detector 3 receives is the integration to the whole outgoing curve of spectrum, so when reach maximum optical power value, outgoing
Shown in solid in the curve of spectrum such as Fig. 5；After the test substance in fluid to be measured 7 is adsorbed by biological surface film 6, biological surface film
6 thickness increases, and the effective refractive index for TE pattern changes slowly, and the effective refractive index for TM pattern changes very greatly,
Lead to the effective refractive index of TE and TM variant, the optical resonator outgoing curve of spectrum under two polarization modes is misaligned, this
When the luminous power that receives of detector 3 reduce, the outgoing curve of spectrum is as shown in phantom in Figure 5.So can be whole by measurement
The change of the total optical power change detection biological surface film thickness in spectrum, thus learn test substance composition in fluid to be measured 7
Content, as shown in Figure 6.In this example, maximum sensitivity reaches 0.5dB/nm, if minimum detectable changed power is
0.01dB, the minimum change thickness that biological surface film detects is 2.0 × 10-2nm.
Above-described embodiment is used for illustrating the present invention, rather than limits the invention.The present invention spirit and
In scope of the claims, any modifications and changes that the present invention is made, both fall within protection scope of the present invention.
Claims (4)
1. a kind of biosensor being cascaded with reflective polarizing transducer based on optical resonator is it is characterised in that include wide
Band light source (1), circulator (2), detector (3), optical resonator (4) and reflective polarizing transducer (5)；Described circulator
(2) first port (21) is connected with wideband light source (1)；The second port (22) of described circulator (2) and optical resonator (4)
Input (41) connect；3rd port (23) of described circulator (2) is connected with detector (3)；Described optical resonator (4)
Outfan (42) be connected with reflective polarizing transducer (5)；Described optical resonator (4) inner waveguide sandwich layer (81) surface tool
There is the biological surface film (6) of specific adsorption function；The biological surface film (6) of described optical resonator and fluid to be measured (7) connect
Touch；Described reflective polarizing transducer (5) includes polarization converter (51) and reflecting mirror (52)；By adjusting biological surface film
(6) thickness, realize described optical resonator (4) for two kinds of polarized light of TE with TM pattern effective refractive index identical so that
All resonant frequencies for TE pattern for the described optical resonator (4) are overlapped with all resonant frequencies for TM pattern.
2. a kind of biosensor based on the cascade of optical resonator and reflective polarizing transducer according to claim 1,
It is characterized in that, the specific adsorption to test substance in fluid to be measured (7) for the described biological surface film (6), cause described optics
The TM pattern effective refractive index change of resonator cavity (4) is violent, but the change of TE pattern effective refractive index is slowly so that described optics is humorous
When a resonant frequency for TE pattern for the chamber (4) of shaking is overlapped with a resonant frequency for TM pattern, other are adjacent humorous
The peak that shakes not exclusively overlaps, thus producing cursor effect.
3. a kind of biosensor based on the cascade of optical resonator and reflective polarizing transducer according to claim 1,
It is characterized in that, described optical resonator (4) has the structure of periodic filtering characteristic, moors sieve chamber or annular using Fabry
Resonator cavity.
4. a kind of biosensor based on the cascade of optical resonator and reflective polarizing transducer according to claim 1,
It is characterized in that, described optical resonator (4) can adopt Planar integration fiber waveguide, or discrete optical element, or optical fiber structure
Become.
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| CN106483099B (en) * | 2016-09-30 | 2019-02-22 | 浙江大学 | Based on tunable filter and the cascade optical biosensor of Michelson's interferometer |
| CN109030376B (en) * | 2018-07-10 | 2021-04-06 | 曲阜师范大学 | Label-free biosensor based on optical fiber polarization modulation and implementation method thereof |
| CN109709069B (en) * | 2018-12-26 | 2020-10-23 | 中国科学院半导体研究所 | Gas sensor and preparation method thereof |
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| US7167615B1 (en) * | 1999-11-05 | 2007-01-23 | Board Of Regents, The University Of Texas System | Resonant waveguide-grating filters and sensors and methods for making and using same |
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| CN102353651A (en) * | 2011-07-07 | 2012-02-15 | 天津大学 | Measuring apparatus for refractive index of active photonic crystal fiber |
| CN103134636A (en) * | 2013-01-22 | 2013-06-05 | 中国计量学院 | Optical fiber harmonic oscillator vacuum sensor |
| CN103852093A (en) * | 2013-12-19 | 2014-06-11 | 哈尔滨工业大学（威海） | Fiber laser sensing system based on mode interference reflection structure |
| CN104155244A (en) * | 2014-08-08 | 2014-11-19 | 浙江大学 | Optical-waveguide biosensor for smartphone |
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