CN104547958A - Traditional Chinese medicine preparation with effects of promoting digestion and reducing lipid and preparation method - Google Patents
Traditional Chinese medicine preparation with effects of promoting digestion and reducing lipid and preparation method Download PDFInfo
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- CN104547958A CN104547958A CN201510063105.6A CN201510063105A CN104547958A CN 104547958 A CN104547958 A CN 104547958A CN 201510063105 A CN201510063105 A CN 201510063105A CN 104547958 A CN104547958 A CN 104547958A
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Abstract
The invention discloses a traditional Chinese medicine preparation with the effects of promoting digestion and reducing lipid and a preparation method thereof. The traditional Chinese medicine preparation is prepared from the following main active pharmaceutical ingredients in parts by weight: 5-9 parts of radix notoginseng, 6-8 parts of rhubarb (processed with wine), 8-12 parts of round cardamom fruit, 9-13 parts of giant typhonium rhizome, 10-20 parts of eucommia bark, 8-15 parts of motherwort fruit, 7-14 parts of turmeric root-tuber, 8-16 parts of Chinese taxillus twig, 3-6 parts of whole plants of peanuts, 9-12 parts of glossy privet fruit, 8-12 parts of tea root, 5-10 parts of giant knotweed rhizome, 6-9 parts of Chinese magnoliavine fruit, 10-20 parts of stem of noble dendrobium, 10-20 parts of fragrant solomonseal rhizome, 9-16 parts of palmleaf raspberry fruit and 9-12 parts of Chinese dodder seed. The traditional Chinese medicine preparation does not have toxic or side effects, has definite curative effects, is safe and effective and prevents diseases from relapsing easily.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to one and to help digestion lipid-lowering Chinese medicine preparation and preparation method thereof.
Background technology
Hyperlipidemia is a kind of systemic disease, refers to blood cholesterol (TC) and/or triglyceride (TG) is too high or HDL-C (HDL-C) is too low, and modern medicine is referred to as dyslipidemia.Lipid is insoluble or be slightly soluble in water, must exist with protein bound with lipoprotein form, and therefore, hyperlipidemia is generally hyperlipoproteinemia, and namely serum lipoprotein concentration raises.At present generally acknowledge hyperlipidemia, comprise hypercholesterolemia, hypertriglyceridemia and plyability hyperlipidemia that the two is all high.Hyperlipidemia is common a kind of disease, and in body, the too high health that can affect health of blood lipid level, brings out many complication.The symptom main manifestations of hyperlipidemia can be divided into the following aspects: first: slight hyperlipidemia is usually without any uncomfortable sensation, but there do not have symptom to be not equal to blood fat to be not high, makes regular check on blood fat most important.Second: the symptom of general hyperlipidemia shows as more: dizziness, spiritlessness and weakness, insomnia forgetfulness, numb limbs and tense tendons, uncomfortable in chest, cardiopalmus etc., also can obscure mutually with the clinical symptoms of other diseases, some patients with lipid are high but asymptomatic, are usually to find hyperlipemia when health check-up chemical examination blood.In addition, hyperlipemia is usually along with overweight and obesity.3rd, there will be when hyperlipidemia is heavier have a dizzy spell, have a headache, uncomfortable in chest, breathe hard, have palpitation, chest pain, weak, distortion of commissure, the symptom such as mute, numb limbs and tense tendons, finally can cause the serious disease such as coronary heart disease, apoplexy, and occur corresponding performance.4th, long-term blood fat is high, and the atherosclerosis of lipid caused by blood vessel endothelium deposition, can cause coronary heart disease and peripheral arterial disease etc., show as angina pectoris, myocardial infarction, apoplexy and intermittent claudication (after limb activity pain).The harm of hyperlipidemia is unconspicuous, Progressive symmetric erythrokeratodermia and general gradually to health.The direct infringement of hyperlipidemia is the process accelerating systemic atherosclerosis.Because the vitals of whole body all will rely on tremulous pulse blood supply, oxygen supply.Once tremulous pulse is blocked by atheromatous plaque, just there will be the serious consequence of organ ischemia.
The traditional Chinese medical science is thought, though cream fat is the nutrient substance of human body, crosses and forms hyperlipidemia at most for suffering from.All to cause human body to take in cream fat too much, and cream fat transfers, utilizes, the factor of abevacuation all can make blood fat raise, its cause of disease have following some.1. emotional stimulation.Worry impairing spleen, dysfunction of the spleen in transportation, or depressed rage impairing the liver, liver is lost bar and reaches, functional activity of QI being not smooth, and the defeated cloth of cream fat transporting is not normal, and blood fat raises.2. physiques and natural endowment.Father and mother are fat, greasiness since the childhood, and after growing up, body is more plump, and how not enough yang-energy is often, and body fluid cream fat defeatedization is slow, and it is too much to educate matter in blood.Or ferritic hyperactivity of YANG due to deficiency of YIN, esterified for educating, dissolve in blood, blood fat raises.3. happiness is quiet few dynamic.Or natural disposition happiness is quiet, greedy sleeping is moved less; Or limit because of Job, bend over the desk all day, sit few walk, human functional activity of vital energy loses in dredging smooth, and then the defeated cloth of body fluid is unfavorable for the stagnation of QI, and cream fat trans-utilization is too late, so that raw multiplex few, and in lithosomic body, in contamination blood, therefore blood fat raises.4. worn with age.People is old, and the then vital organs of the human body all decline, based on kidney: kidney master five liquid, suffer from a deficiency of the kidney, and body fluid loses it and dominates; The spleen has the function to transport and transform nutrients, insufficiency of the spleen, and diet is reforming not; Liver controlling conveyance and dispersion, the defeated cloth of the weak then body fluid of liver is unfavorable, and three all makes cream lipid metabolism not normal, causes blood fat to raise.If excess of sexual intercourse, painstaking worried, people end also can be made always and first to decline.5. the card such as to quench one's thirst, edema, hypochondriac pain, jaundice, disease are long-pending is not healed.It is scorching that diabete basic pathogenesis belongs to the deficiency of YIN, owing to disturbing in asthenic fire, and polyphagia due to stomach-heat, the normal polydipsia polyphagia of patient, but diet is precise and tiny can not become fat and preserve, and the fat of human body is anti-molten is to the greatest extent cream, is mixed in blood, causes blood fat to raise.With the passing of time edema, undermines spleen kidney, and suffering from a deficiency of the kidney can not main liquid, insufficiency of the spleenly loses in strong fortune, so that cream lipid metabolism is not normal.Hypochondriac pain, jaundice, disease amass the disease that three all belongs to liver, gallbladder, and hepatopathy mechanism of qi loses in catharsis, and the compress affecting cream fat transforms, and gallbladder disease can not turbidity fat only, causes blood fat to raise.6. diet is improper.Eating and drinking without temperance, hyperingestion, or throw off restraint the rich sweet savoury of food, too much cream fat enters human body with diet, defeated cloth, transforms too late, and be detained in blood, thus blood fat raises.Chronic dietary is improper, or excessive drinking excessively, undermines taste, and strong fortune mistake department, causes diet not reforming, can not change precise and tiny in nutrition whole body, becomes raw fat on the contrary turbid, is mixed in blood, causes blood fat to raise.The former is excess syndrome, and the latter is deficiency complicated with excess card, and this is the two difference.
Treatment: 1. control ideal body weight.Many epidemiologic data displays, mean plasma cholesterol and the serum triglyceride level of obese people are significantly higher than non-obese person of the same age.Except Body Mass Index (BMI) and blood lipid level are except obvious positive correlation, the distribution of body fat is also in close relations with blood plasma lipoprotein level.After the losing weight of overweight people, blood fat disorder also can recover normal.2. motion exercise.Sports not only can strengthen cardio-pulmonary function, improve insulin resistant and glucose tolerance, but also can lose weight, reduce blood plasma triacylglycerol and cholesterol levels, raises HDL cholesterol level.3. give up smoking.Smoking can elevate plasma cholesterol and serum triglyceride level, reduces HDL-cholesterol levels.Stop smoking 1 year, plasma HDL-cholesterol can rise to the level of non-smoker, and the degree of danger of coronary heart disease can reduce by 50%, even close to non-smoker.4. Diet Therapy.Blood plasma lipide is mainly derived from food, by keeping on a diet, blood plasma cholesterol level can be made to reduce by 5% ~ 10%, contribute to fat-reducing simultaneously.And make fat-reducing medicament give play to best effect.Usually, the cholesterol in the foods (particularly egg yolk and pluck) such as carnivorous, egg and milk product and saturated fatty acid content more, limes reacting dose is taken food.Edible oil should based on vegetable oil, and consumption is advisable with 25 ~ 30g for each person every day.5. Drug therapy.Statins and resinae is had based on what reduce serum total cholesterol and LDL-C.The special class of shellfish and nicotinic acid class is had based on the medicine reducing serum triacylglycerol.6. the non-drug therapy of severe dyslipidemia.The blood lipid regulation effect that the patient of part dyslipidemia all can reach more satisfactory by adjustment diet and mode of making the life better, there is only a few blood lipid very high, be more common in the patient of gene genetic exception, can be treated by plasma purification, surgical intervention.Gene therapy will likely capture the genetic dyslipidemia of intractable in future.
Application publication number CN 103251747 A(application number 201310192100.4) Chinese patent literature disclose a kind of Chinese medicine preparation with the effect of blood fat reducing dredging collateral, comprise the crude drug of following weight portion: Fructus Crataegi 200 ~ 300 parts, Pollen Tyjphae 150 ~ 200 parts, Radix Polygoni Multiflori Preparata 150 ~ 200 parts, Semen Cassiae 150 ~ 200 parts, Folium Ginkgo 150 ~ 200 parts.Publication number CN 1593570A(application number 200410040123.4) Chinese patent literature disclose a kind of Chinese medicine of blood fat reducing, it is formulated by Herba Artemisiae Scopariae, Fructus Trichosanthis, Bulbus Allii Macrostemonis, Fructus Crataegi, Fructus Atriplicis Sibiricae, the Radix Polygoni Multiflori, Pollen Typhae, Radix Notoginseng, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Folium Ginkgo, Flos Sophorae, Rhizoma Alismatis, Radix Bupleuri, Rhizoma Curcumae Longae.Application publication number CN 102907745 A(application number 201210353141.2) Chinese patent literature discloses solid beverage of a kind of clearing away liver fire and reducing fat and preparation method thereof, adopt the raw material of following parts by weight: Fructus Lycii 16 ~ 40 parts, Flos Chrysanthemi 14 ~ 25 parts, Semen Cassiae 15 ~ 20 parts, Fructus Crataegi 15 ~ 45 parts, sucrose 240 ~ 380 parts, sieves obtained through decocting and concentrating, mixing granulation, oven dry.
At present, Modern medical therapy hyperlipemia mainly uses the medicine of Statins and Bei Te class, statins as simvastatin, lovastatin, pravastatin etc., mainly cholesterol reducing; Fibrate as fenofibrate, stupid bundle shellfish top grade, mainly triglyceride reducing.This two classes Western medicine has certain effect for reducing fat, but they more or less have certain side effect, great majority have infringement in various degree to liver or other organs, myalgia may be there is after long-term taking, or infringement liver occurs that transaminase raises, or albuminuria appears in infringement kidney, even creatinine and blood urea nitrogen raise, and serious also can causing death.And blood fat bounce-back probability is higher after drug withdrawal.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide one and to help digestion lipid-lowering Chinese medicine preparation and preparation method thereof.The present invention has no side effect, determined curative effect, safe and effective, not easily recurs.
Technical scheme of the present invention is:
One helps digestion lipid-lowering Chinese medicine preparation, takes off the primary raw material medicine stating weight proportion and is prepared from: Radix Notoginseng 5-9, Radix Et Rhizoma Rhei (processed with wine) 6-8, Fructus Amomi Rotundus 8-12, Rhizoma Typhonii 9-13, Cortex Eucommiae 10-20, Fructus Leonuri 8-15, Radix Curcumae 7-14, Herba Taxilli 8-16, Semen arachidis hypogaeae herb 3-6, Fructus Ligustri Lucidi 9-12, Radix Camelliae sinensis 8-12, Rhizoma Polygoni Cuspidati 5-10, Fructus Schisandrae Chinensis 6-9, Herba Dendrobii 10-20, Rhizoma Polygonati Odorati 10-20, Fructus Rubi 9-16, Semen Cuscutae 9-12.
One helps digestion lipid-lowering Chinese medicine preparation, and preferred scheme is, takes off the primary raw material medicine stating weight proportion and is prepared from: Radix Notoginseng 6-8, Radix Et Rhizoma Rhei (processed with wine) 6.5-7.5, Fructus Amomi Rotundus 9-11, Rhizoma Typhonii 10-12, Cortex Eucommiae 13-17, Fructus Leonuri 10-12, Radix Curcumae 9-11, Herba Taxilli 11-13, Semen arachidis hypogaeae herb 3.5-5.5, Fructus Ligustri Lucidi 10-11.5, Radix Camelliae sinensis 9-11, Rhizoma Polygoni Cuspidati 7-9, Fructus Schisandrae Chinensis 7-8.5, Herba Dendrobii 14-16, Rhizoma Polygonati Odorati 13-16, Fructus Rubi 11-14, Semen Cuscutae 10-11.5.
One helps digestion lipid-lowering Chinese medicine preparation, and the scheme be more preferably is, takes off the primary raw material medicine stating weight proportion and is prepared from: Radix Notoginseng 7, Radix Et Rhizoma Rhei (processed with wine) 7, Fructus Amomi Rotundus 10, Rhizoma Typhonii 11, the Cortex Eucommiae 15, Fructus Leonuri 11, Radix Curcumae 10, Herba Taxilli 12, Semen arachidis hypogaeae herb 4.5, Fructus Ligustri Lucidi 10.5, Radix Camelliae sinensis 10, Rhizoma Polygoni Cuspidati 8, Fructus Schisandrae Chinensis 7.5, Herba Dendrobii 15, Rhizoma Polygonati Odorati 14, Fructus Rubi 12, Semen Cuscutae 10.5.
Present invention also offers the preparation method aforementioned lipid-lowering Chinese medicine preparation that helps digestion being made pharmaceutically acceptable granule, pill, tablet and decoction.
The preparation method of described granule is:
(1) clean Radix Et Rhizoma Rhei is got, add yellow wine to mix thoroughly, every 100kg Radix Et Rhizoma Rhei yellow wine 27-35kg(is every 100kg Radix Et Rhizoma Rhei yellow wine 33kg preferably), moistening 57-72 minute (preferred moistening 65 minutes), puts in pot, at the temperature of 105 DEG C-125 DEG C (under being preferable over the temperature of 118 DEG C), fry 14-20 minute (preferably frying 18 minutes), take out, cool, be ground into fine powder, cross No. five sieves;
(2) the saturated lime water of Rhizoma Typhonii is soaked 20-28 hour (preferably the saturated lime water of Rhizoma Typhonii being soaked 24 hours), every 100kg Rhizoma Typhonii quicklime 10-15kg(is every 100kg Rhizoma Typhonii quicklime 13kg preferably), take out, clear water is cleaned, and puts in food steamer, heat with high heat, steam 3.5-5.5 hour (preferably steaming 4.5 hours), take out, dry, be ground into fine powder, cross No. five sieves;
(3) Semen Cuscutae is loaded in gauze bag, marmite is put into all the other the 14 taste crude drug except Radix Et Rhizoma Rhei and Rhizoma Typhonii, decoct with water twice, amount of water is the 4.5-6.5 of the 15 taste crude drug gross weights added doubly (preferred amount of water is 5.5 times of the 15 taste crude drug gross weights added), each decoction 58-78 minute (preferably each decoction 68 minutes), filter, merging filtrate, is concentrated into the clear paste (being preferably concentrated into the clear paste of relative density 1.17) of relative density 1.11-1.19;
(4) step (3) gained clear paste and step (1) and step (2) gained fine powder are mixed, with fashion of extrusion by 12-20 eye mesh screen (preferably passing through 16 eye mesh screens with fashion of extrusion), make uniform granule, adopt fluid bed airpillow-dry, temperature controls at 60-65 DEG C, the water content control of granule within 2%, granulate subpackage and get final product.
The preparation method of described pill is:
(1) clean Radix Et Rhizoma Rhei is got, add yellow wine to mix thoroughly, every 100kg Radix Et Rhizoma Rhei yellow wine 27-35kg(is every 100kg Radix Et Rhizoma Rhei yellow wine 33kg preferably), moistening 57-72 minute (preferred moistening 65 minutes), puts in pot, at the temperature of 105 DEG C-125 DEG C (under being preferable over the temperature of 118 DEG C), fry 14-20 minute (preferably frying 18 minutes), take out, cool, be ground into fine powder, cross No. five sieves;
(2) the saturated lime water of Rhizoma Typhonii is soaked 20-28 hour (preferably the saturated lime water of Rhizoma Typhonii being soaked 24 hours), every 100kg Rhizoma Typhonii quicklime 10-15kg(is every 100kg Rhizoma Typhonii quicklime 13kg preferably), take out, clear water is cleaned, and puts in food steamer, heat with high heat, steam 3.5-5.5 hour (preferably steaming 4.5 hours), take out, dry, be ground into fine powder, cross No. five sieves;
(3) all the other the 15 taste crude drug except Radix Et Rhizoma Rhei and Rhizoma Typhonii are ground into fine powder respectively, cross No. five sieves;
(4) step (1), step (2) and step (3) gained fine powder are fully mixed, with yellow wine (alcohol content 12-15%) general ball, to make diameter be the preferred diameter of 2-3mm(is 2.5mm) pill, adopt fluid bed airpillow-dry, temperature controls at 50-55 DEG C, and by the water content control of pill 4%.
The preparation method of described tablet is:
(1) clean Radix Et Rhizoma Rhei is got, add yellow wine to mix thoroughly, every 100kg Radix Et Rhizoma Rhei yellow wine 27-35kg(is every 100kg Radix Et Rhizoma Rhei yellow wine 33kg preferably), moistening 57-72 minute (preferred moistening 65 minutes), puts in pot, at the temperature of 105 DEG C-125 DEG C (under being preferable over the temperature of 118 DEG C), fry 14-20 minute (preferably frying 18 minutes), take out, cool, be ground into fine powder, cross No. five sieves;
(2) the saturated lime water of Rhizoma Typhonii is soaked 20-28 hour (preferably the saturated lime water of Rhizoma Typhonii being soaked 24 hours), every 100kg Rhizoma Typhonii quicklime 10-15kg(is every 100kg Rhizoma Typhonii quicklime 13kg preferably), take out, clear water is cleaned, and puts in food steamer, heat with high heat, steam 3.5-5.5 hour (preferably steaming 4.5 hours), take out, dry, be ground into fine powder, cross No. five sieves;
(3) Semen Cuscutae is loaded in gauze bag, marmite is put into all the other the 14 taste crude drug except Radix Et Rhizoma Rhei and Rhizoma Typhonii, decoct with water twice, amount of water is the 3.8-5.8 of the 15 taste crude drug gross weights added doubly (preferred amount of water is 4.8 times of the 15 taste crude drug gross weights added), each decoction 58-78 minute (preferably each decoction 70 minutes), filter, merging filtrate, is concentrated into the clear paste (being preferably concentrated into the clear paste of relative density 1.16) of relative density 1.09-1.21;
(4) step (3) gained clear paste and step (1) and step (2) gained fine powder are mixed, with fashion of extrusion by 12-20 eye mesh screen (preferably passing through 16 eye mesh screens with fashion of extrusion), make uniform granule, adopt fluid bed airpillow-dry, temperature controls at 50-55 DEG C, the water content control of granule within 2%, tabletting, the heavy 0.25g of every sheet, to obtain final product.
The preparation method of described decoction is:
(1) clean Radix Et Rhizoma Rhei is got, add yellow wine to mix thoroughly, every 100kg Radix Et Rhizoma Rhei yellow wine 27-35kg(is every 100kg Radix Et Rhizoma Rhei yellow wine 33kg preferably), moistening 57-72 minute (preferred moistening 65 minutes), puts in pot, at the temperature of 105 DEG C-125 DEG C (under being preferable over the temperature of 118 DEG C), fry 14-20 minute (preferably frying 18 minutes), take out, cool, be ground into fine powder, cross No. six sieves;
(2) the saturated lime water of Rhizoma Typhonii is soaked 20-28 hour (preferably the saturated lime water of Rhizoma Typhonii being soaked 24 hours), every 100kg Rhizoma Typhonii quicklime 10-15kg(is every 100kg Rhizoma Typhonii quicklime 13kg preferably), take out, clear water is cleaned, and puts in food steamer, heat with high heat, steam 3.5-5.5 hour (preferably steaming 4.5 hours), take out, dry, be ground into fine powder, cross No. six sieves;
(3) Semen Cuscutae is loaded in gauze bag, marmite is put into all the other the 14 taste crude drug except Radix Et Rhizoma Rhei and Rhizoma Typhonii, add water, amount of water is 3.2-5.4 times (preferred amount of water is 4.5 times of the 15 taste crude drug gross weights added) of the 15 taste crude drug gross weights added, first boil with high heat to boiling, after continue to give slow fire boiling 30-42 minute (continuing to give slow fire boiling 35 minutes preferably), leach medicinal liquid;
(4) add water in the marmite filling medicinal residues, amount of water is 2.5-3.8 times (preferred amount of water is 3 times of the 15 taste crude drug gross weights added) of the 15 taste crude drug gross weights added, first boil with high heat to boiling, after continue to give slow fire boiling 28-38 minute (continuing to give slow fire boiling 33 minutes preferably), leach medicinal liquid;
(5) step (3) and step (4) gained medicinal liquid are merged, and step (1) and step (2) gained fine powder are added in the medicinal liquid after merging, to obtain final product.
The lipid-lowering Chinese medicine preparation that helps digestion provided by the invention has no side effect, safe and effective.In addition, excellent results of the present invention also shows:
1, easy to use, improve the compliance of patient, to consolidate and lifting helps digestion lipid-lowering effect;
2, with traditional Chinese medical science traditional theory for instruct, scientific formula is reasonable;
3, have the effect such as blood circulation promoting and blood stasis dispelling, depressed liver-energy dispersing and function of gallbladder promoting, dispelling wind and removing obstruction in the collateral, kidney calming, the stomach reinforcing that promotes the production of body fluid, appetite-stimulating indigestion-relieving, clearing away heat-damp and promoting diuresis, nourishing the liver and kidney, promoting QI circulation for relieving depression, interior clearind deficient heat, the Bloodlipid-lowering that helps digestion is remarkable.
4, preparation method is simple;
5, medicine source is easy to get;
6, there is the effect regulating body, treating both the principal and secondary aspects of a disease, not easily recur.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1one helps digestion lipid-lowering Chinese medicine preparation, and the primary raw material medicine getting following weight parts is prepared from (every part is 110g): Radix Notoginseng 5 parts, Radix Et Rhizoma Rhei (processed with wine) 6 parts, Fructus Amomi Rotundus 8 parts, Rhizoma Typhonii 9 parts, the Cortex Eucommiae 10 parts, Fructus Leonuri 8 parts, Radix Curcumae 7 parts, Herba Taxilli 8 parts, Semen arachidis hypogaeae herb 3 parts, Fructus Ligustri Lucidi 9 parts, Radix Camelliae sinensis 8 parts, Rhizoma Polygoni Cuspidati 5 parts, Fructus Schisandrae Chinensis 6 parts, Herba Dendrobii 10 parts, Rhizoma Polygonati Odorati 10 parts, Fructus Rubi 9 parts, Semen Cuscutae 9 parts.
The above-mentioned preparation method helping digestion lipid-lowering Chinese medicine preparation decoction is:
(1) get clean Radix Et Rhizoma Rhei, add yellow wine and mix thoroughly, every 100kg Radix Et Rhizoma Rhei yellow wine 27kg, moistening 57 minutes, puts in pot, at the temperature of 105 DEG C, fries 14 minutes, takes out, cools, be ground into fine powder, crosses No. six sieves;
(2) the saturated lime water of Rhizoma Typhonii is soaked 20 hours, every 100kg Rhizoma Typhonii quicklime 10kg, take out, clear water is cleaned, and puts in food steamer, heats with high heat, steam 3.5 hours, takes out, dries, be ground into fine powder, crosses No. six sieves;
(3) Semen Cuscutae is loaded in gauze bag, put into marmite with all the other the 14 taste crude drug except Radix Et Rhizoma Rhei and Rhizoma Typhonii, add water, amount of water is 3.2 times of the 15 taste crude drug gross weights added, first boil with high heat to boiling, rear continuation gives slow fire boiling 30 minutes, leaches medicinal liquid;
(4) add water in the marmite filling medicinal residues, amount of water is 2.5 times of the 15 taste crude drug gross weights added, and first boil with high heat to boiling, rear continuation gives slow fire boiling 28 minutes, leaches medicinal liquid;
(5) step (3) and step (4) gained medicinal liquid are merged, and step (1) and step (2) gained fine powder are added in the medicinal liquid after merging, to obtain final product.
The present invention helps digestion the instructions of taking of lipid-lowering Chinese medicine preparation decoction: oral, every day twice, and each 180mL is warm.
embodiment 2one helps digestion lipid-lowering Chinese medicine preparation, and the primary raw material medicine getting following weight parts is prepared from (every part is 110g): Radix Notoginseng 9 parts, Radix Et Rhizoma Rhei (processed with wine) 8 parts, Fructus Amomi Rotundus 12 parts, Rhizoma Typhonii 13 parts, the Cortex Eucommiae 20 parts, Fructus Leonuri 15 parts, Radix Curcumae 14 parts, Herba Taxilli 16 parts, Semen arachidis hypogaeae herb 6 parts, Fructus Ligustri Lucidi 12 parts, Radix Camelliae sinensis 12 parts, Rhizoma Polygoni Cuspidati 10 parts, Fructus Schisandrae Chinensis 9 parts, Herba Dendrobii 20 parts, Rhizoma Polygonati Odorati 20 parts, Fructus Rubi 16 parts, Semen Cuscutae 12 parts.
The above-mentioned preparation method helping digestion lipid-lowering Chinese medicine preparation granule is:
(1) get clean Radix Et Rhizoma Rhei, add yellow wine and mix thoroughly, every 100kg Radix Et Rhizoma Rhei yellow wine 33kg, moistening 65 minutes, puts in pot, at the temperature of 118 DEG C, fries 18 minutes, takes out, cools, be ground into fine powder, crosses No. five sieves;
(2) the saturated lime water of Rhizoma Typhonii is soaked 24 hours, every 100kg Rhizoma Typhonii quicklime 13kg, take out, clear water is cleaned, and puts in food steamer, heats with high heat, steam 4.5 hours, takes out, dries, be ground into fine powder, crosses No. five sieves;
(3) Semen Cuscutae is loaded in gauze bag, put into marmite with all the other the 14 taste crude drug except Radix Et Rhizoma Rhei and Rhizoma Typhonii, decoct with water twice, amount of water is 5.5 times of the 15 taste crude drug gross weights added, and each decoction 68 minutes, filters, merging filtrate, is concentrated into the clear paste of relative density 1.17;
(4) step (3) gained clear paste and step (1) and step (2) gained fine powder are mixed, with fashion of extrusion by 16 eye mesh screens, make uniform granule, adopt fluid bed airpillow-dry, temperature controls at 60-65 DEG C, the water content control of granule within 2%, granulate subpackage and get final product.
model case one:liu XX, man, 55 years old.Main suit: uncomfortable in chest, dizzy, breathe hard more than 1 year, increases the weight of 3 months.Over 1 year patient often feel headache uncomfortable in chest, chest pain, both sides of the chest distending pain, dizziness headache, breathe hard, vexed uneasiness, hands time have vibration, once arrive neighbouring clinic and accept Drug therapy, the state of an illness slightly takes a turn for the better.Above-mentioned exacerbation of symptoms before 3 months, comes to go to a doctor then.Examine and see that patient's body of the tongue is dark violet, have petechia ecchymosis, thin fur, stringy pulse and puckery.Be diagnosed as qi stagnation and blood stasis type hyperlipidemia.Take the present embodiment gained to help digestion lipid-lowering Chinese medicine preparation granule, every day three times, each 4g, boiled water is taken after mixing it with water.Take two weeks, symptom obviously alleviates.Continue to take three weeks, all diseases disappear, and blood fat is normal.Follow up a case by regular visits to and have no bounce-back.
embodiment 3one helps digestion lipid-lowering Chinese medicine preparation, and the primary raw material medicine getting following weight parts is prepared from (every part is 110g): Radix Notoginseng 6 parts, Radix Et Rhizoma Rhei (processed with wine) 6.5 parts, Fructus Amomi Rotundus 9 parts, Rhizoma Typhonii 10 parts, the Cortex Eucommiae 13 parts, Fructus Leonuri 10 parts, Radix Curcumae 9 parts, Herba Taxilli 11 parts, Semen arachidis hypogaeae herb 3.5 parts, Fructus Ligustri Lucidi 10 parts, Radix Camelliae sinensis 9 parts, Rhizoma Polygoni Cuspidati 7 parts, Fructus Schisandrae Chinensis 7 parts, Herba Dendrobii 14 parts, Rhizoma Polygonati Odorati 13 parts, Fructus Rubi 11 parts, Semen Cuscutae 10 parts.
The above-mentioned preparation method helping digestion lipid-lowering Chinese medicine preparation pill is:
(1) get clean Radix Et Rhizoma Rhei, add yellow wine and mix thoroughly, every 100kg Radix Et Rhizoma Rhei yellow wine 33kg, moistening 65 minutes, puts in pot, at the temperature of 118 DEG C, fries 18 minutes, takes out, cools, be ground into fine powder, crosses No. five sieves;
(2) the saturated lime water of Rhizoma Typhonii is soaked 24 hours, every 100kg Rhizoma Typhonii quicklime 13kg, take out, clear water is cleaned, and puts in food steamer, heats with high heat, steam 4.5 hours, takes out, dries, be ground into fine powder, crosses No. five sieves;
(3) all the other the 15 taste crude drug except Radix Et Rhizoma Rhei and Rhizoma Typhonii are ground into fine powder respectively, cross No. five sieves;
(4) step (1), step (2) and step (3) gained fine powder are fully mixed, with yellow wine (alcohol content 12-15%) general ball, make the pill that diameter is 2.5mm, adopt fluid bed airpillow-dry, temperature controls at 50-55 DEG C, and by the water content control of pill 4%.
model case two:feng XX, female, 49 years old.Main suit: being irritable and getting angry easily, forgetful insomnia, more than myasthenia of limbs half a year.Before half a year, patient starts to occur being irritable and getting angry easily, forgetful insomnia, myasthenia of limbs, and with uncomfortable in chest, abdominal distention is just clear.Once took Chinese and western medical, the state of an illness has no and is clearly better, and then comes to go to a doctor.Examine and see patient's pale tongue with white fur, stringy and thready pulse.Be diagnosed as liver-depression and spleen-insufficiency type hyperlipidemia.Take the present embodiment gained to help digestion lipid-lowering Chinese medicine preparation pill, every day three times, each 8 balls, warm water delivery service.Take two weeks, above-mentioned symptom obviously alleviates.Continue to take two weeks, all disease knowing disappear, and fat of having a blood test has no normal.Follow up a case by regular visits to and have no recurrence.
embodiment 4one helps digestion lipid-lowering Chinese medicine preparation, and the primary raw material medicine getting following weight parts is prepared from (every part is 110g): Radix Notoginseng 8 parts, Radix Et Rhizoma Rhei (processed with wine) 7.5 parts, Fructus Amomi Rotundus 11 parts, Rhizoma Typhonii 12 parts, the Cortex Eucommiae 17 parts, Fructus Leonuri 12 parts, Radix Curcumae 11 parts, Herba Taxilli 13 parts, Semen arachidis hypogaeae herb 5.5 parts, Fructus Ligustri Lucidi 11.5 parts, Radix Camelliae sinensis 11 parts, Rhizoma Polygoni Cuspidati 9 parts, Fructus Schisandrae Chinensis 8.5 parts, Herba Dendrobii 16 parts, Rhizoma Polygonati Odorati 16 parts, Fructus Rubi 14 parts, Semen Cuscutae 11.5 parts.
The above-mentioned preparation method helping digestion lipid-lowering Chinese medicine preparation tablet is:
(1) get clean Radix Et Rhizoma Rhei, add yellow wine and mix thoroughly, every 100kg Radix Et Rhizoma Rhei yellow wine 33kg, moistening 65 minutes, puts in pot, at the temperature of 118 DEG C, fries 18 minutes, takes out, cools, be ground into fine powder, crosses No. five sieves;
(2) the saturated lime water of Rhizoma Typhonii is soaked 24 hours, every 100kg Rhizoma Typhonii quicklime 13kg, take out, clear water is cleaned, and puts in food steamer, heats with high heat, steam 4.5 hours, takes out, dries, be ground into fine powder, crosses No. five sieves;
(3) Semen Cuscutae is loaded in gauze bag, put into marmite with all the other the 14 taste crude drug except Radix Et Rhizoma Rhei and Rhizoma Typhonii, decoct with water twice, amount of water is 4.8 times of the 15 taste crude drug gross weights added, and each decoction 70 minutes, filters, merging filtrate, is concentrated into the clear paste of relative density 1.16;
(4) step (3) gained clear paste and step (1) and step (2) gained fine powder are mixed, with fashion of extrusion by 16 eye mesh screens, make uniform granule, adopt fluid bed airpillow-dry, temperature controls at 50-55 DEG C, the water content control of granule within 2%, tabletting, the heavy 0.25g of every sheet, to obtain final product.
model case three:stone XX, female, 64 years old.Main suit: have a dizzy spell, insomnia and dreamful sleep more than 2 years.Over 2 years, patient often feels to have a dizzy spell, insomnia and dreamful sleep, and with dry mouth and throat, tinnitus is forgetful, and waist knee joint is aching and limp unable, costalgia, and dysphoria with smothery sensation is uneasy.Examine and see the few tongue of patient's red tongue, thready and rapid pulse.Be diagnosed as deficiency of the liver and kidney hyperlipidemia.The present embodiment gained is used to help digestion lipid-lowering Chinese medicine preparation tablet, every day three times, each 3, warm water delivery service.Take 1 month, above-mentioned symptom obviously alleviates.Continue to take two weeks, all disease knowing disappear, and fat of having a blood test recovers normal.Follow up a case by regular visits to and do not recur.
embodiment 5one helps digestion lipid-lowering Chinese medicine preparation, and the primary raw material medicine getting following weight parts is prepared from (every part is 110g): Radix Notoginseng 7 parts, Radix Et Rhizoma Rhei (processed with wine) 7 parts, Fructus Amomi Rotundus 10 parts, Rhizoma Typhonii 11 parts, the Cortex Eucommiae 15 parts, Fructus Leonuri 11 parts, Radix Curcumae 10 parts, Herba Taxilli 12 parts, Semen arachidis hypogaeae herb 4.5 parts, Fructus Ligustri Lucidi 10.5 parts, Radix Camelliae sinensis 10 parts, Rhizoma Polygoni Cuspidati 8 parts, Fructus Schisandrae Chinensis 7.5 parts, Herba Dendrobii 15 parts, Rhizoma Polygonati Odorati 14 parts, Fructus Rubi 12 parts, Semen Cuscutae 10.5 parts.
The above-mentioned preparation method helping digestion lipid-lowering Chinese medicine preparation decoction is:
(1) get clean Radix Et Rhizoma Rhei, add yellow wine and mix thoroughly, every 100kg Radix Et Rhizoma Rhei yellow wine 33kg, moistening 65 minutes, puts in pot, at the temperature of 118 DEG C, fries 18 minutes, takes out, cools, be ground into fine powder, crosses No. six sieves;
(2) the saturated lime water of Rhizoma Typhonii is soaked 24 hours, every 100kg Rhizoma Typhonii quicklime 13kg, take out, clear water is cleaned, and puts in food steamer, heats with high heat, steam 4.5 hours, takes out, dries, be ground into fine powder, crosses No. six sieves;
(3) Semen Cuscutae is loaded in gauze bag, put into marmite with all the other the 14 taste crude drug except Radix Et Rhizoma Rhei and Rhizoma Typhonii, add water, amount of water is 4.5 times of the 15 taste crude drug gross weights added, first boil with high heat to boiling, rear continuation gives slow fire boiling 35 minutes, leaches medicinal liquid;
(4) add water in the marmite filling medicinal residues, amount of water is 3 times of the 15 taste crude drug gross weights added, and first boil with high heat to boiling, rear continuation gives slow fire boiling 33 minutes, leaches medicinal liquid;
(5) step (3) and step (4) gained medicinal liquid are merged, and step (1) and step (2) gained fine powder are added in the medicinal liquid after merging, to obtain final product.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Radix Notoginseng: base is former: be the root of panax araliaceae plant.The property of medicine: sweet in the mouth, micro-hardship, warm in nature.Return liver, stomach, the heart, lung, large intestine channel.Function cures mainly: hemostasis, loose blood, analgesic therapy.Main falling flutters congestive edema, thoracic obstruction angor, lump in the abdomen, blood stasis amenorrhea, dysmenorrhea, and puerperal, stasis of blood the moon was suffered from abdominal pain, sore, carbuncle and painful swelling.
Radix Et Rhizoma Rhei (processed with wine): base is former: be the dry root and rhizome of section of family plant sorrel, Rheum tanguticum or Rheum officinale.The property of medicine: bitter, cold.Return spleen, stomach, large intestine, liver, pericardium channel.Function cures mainly: purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.For excess-heat constipation, stagnant stomachache, dysentery is not well, and damp and hot Huang value, heat in blood tells nosebleed, conjunctival congestion, pharyngeal swelling, abdominalgia with intestinal abscess, and carbuncle treats skin ulcer, blood stasis amenorrhea, traumatic injury, external treatment burn due to hot liquid or fire, upper gastrointestinal hemorrhage.Radix et Rhizoma Rhei (stir-fried with wine) is apt to clear part of the body cavity above the diaphragm housing the heart and lungs noxious heat in the blood system.For conjunctival congestion pharyngeal swelling, gingivitis.
Fructus Amomi Rotundus: base is former: be the mature fruit of zingiberaceous plant Fructus Amomi Rotundus and amomum compactum Soland ex Maton.The property of medicine: acrid in the mouth, warm in nature.Return lung, spleen, stomach warp.Function cures mainly: removing dampness circulation of qi promoting, warming middle-JIAO to arrest vomiting, appetite-stimulating indigestion-relieving.Main retention of damp leading to blockage of QI, incoordination between the spleen and stomach, distension and fullness in the abdomen, anorexia, hygropyrexia from the beginning of, uncomfortable in chest not hungry, gastrofrigid vomiting, food stagnation does not disappear.
Rhizoma Typhonii: base is former: be the tuber of aroid Herba Typhonii gigantei.The property of medicine: acrid in the mouth, sweet, warm in nature, poisonous.Return stomach, Liver Channel.Function cures mainly: dispel the wind expectorant, the meridian dredging, removing toxic substances analgesia.In master, wind-phlegm is stopped up, facial hemiparalysis, migraine, tetanus, venom, scrofula tuberculosis, carbuncle.
The Cortex Eucommiae: base is former: be the dry bark of the Eucommiaceae plant Cortex Eucommiae.The property of medicine: sweet, temperature.Return liver, kidney channel.Function cures mainly: invigorating the liver and kidney, and bone and muscle strengthening is antiabortive.For lumbago due to renal deficiency, muscles and bones is unable, blood leaking in gestation, frequent fetal movement, hypertension.
Fructus Leonuri: base is former: be the fruit of Labiatae mother wort plant Herba Leonuri and Herba Leonuri Sibirici.Composition: leonuri,fructus contains allene class fatty acid containing alkaloid, herb containing phenolic glycoside class, Herba Leonuri Sibirici fruit kind oil.Pharmacology: have hypotensive effect, has the effect of stimulon palace excitement.The property of medicine: sweet, pungent, is slightly cold, mild toxicity.Return Liver Channel.Function cures mainly: blood circulation promoting and blood stasis dispelling, liver heat removing and eyesight improving.For menoxenia, amenorrhea, dysmenorrhea, cataract, dizzy distending pain.
Radix Curcumae: base is former: be the tuber of zingiberaceous plant Rhizoma Curcumae Longae, Radix Curcumae or Rhizoma Curcumae.Chemical analysis: Radix Curcumae tuber is containing volatile oil 6.1%, wherein camphene 0.8%, and Camphora 2.5%, sesquiterpene 65.5%, main is curcumene, sesquiterpene alcohols 22% etc.Also containing curcumin 0.3%, demethoxycurcumin, bisdemethoxycurcumin, turmerone and aryl turmerone.Separately starch-containing 30 ~ 40%, fatty oil 3%, rubber, weld, Eucarvone and phellandrene.Its effective ingredient is p-tolyl-methyl methylol curcumin.The property of medicine: pungent, bitter, cold.GUIXIN, liver, gallbladder meridian.Function cures mainly: invigorate blood circulation only energy, promoting QI circulation for relieving depression, the removing heat from blood that clears away heart-fire, depressed liver-energy dispersing and function of gallbladder promoting.The all pains of main breast abdomen side of body rib, dysmenorrhes, amenorrhea, lump in the abdomen caking, calentura coma, demented, infantile convulsion, haematemesis, nosebleed are standby, stranguria with blood, sand Stranguria, jaundice.
Herba Taxilli: base is former: be the branch and leaf of Loranthaceae plant Herba Taxilli, Sichuan parasitism, Ramulus Scurmlae Parasificae, the blunt fruit parasitism of hair leaf.The property of medicine: bitter, sweet, property is put down.Return liver, kidney channel.Function cures mainly: invigorating the liver and kidney, bone and muscle strengthening, and wind-damp dispelling is antiabortive.Main soreness of waist and knee joint, muscles and bones flaccidity is weak, and limbs are hemiplegia, rheumatic arthralgia, and head mistake is dizzy, frequent fetal movement, metrostaxis.
Semen arachidis hypogaeae herb: base is former: the dry herb of Papilionaceae Arachis annual herb plant Semen arachidis hypogaeae.The property of medicine: sweet in the mouth, property is put down.Function cures mainly: tranquillizing and allaying excitement, reduces blood pressure.Blood pressure drops can be made.
Fructus Ligustri Lucidi: base is former: be the fruit of Oleaceae plants Fructus Ligustri Lucidi.The property of medicine: sweet, bitter, cool in nature.Return liver, kidney channel.Function cures mainly: liver and kidney tonifying, clearind deficient heat, improving eyesight.Main Light-headedness, soreness of the waist and knees, seminal emission, tinnitus, early whitening of beard and hair, osteopyrexia and fever, poor vision.
Radix Camelliae sinensis: base is former: be the root of plant of theaceae tea.The property of medicine: bitter, cool.GUIXIN, kidney channel.Function cures mainly: heart tonifying diuresis, promoting blood flow to regulate menstruation, heat-clearing and toxic substances removing.Main heart disease, edema, hepatitis, dysmenorrhea, sore swollen toxin, aphtha, soup fire is burnt, herpes zoster, psoriasis.
Rhizoma Polygoni Cuspidati: base is former: be rhizome and the root of polygonaceae plant Rhizoma Polygoni Cuspidati.The property of medicine: bitter, acid, cold nature.Return liver, gallbladder meridian.Function cures mainly: promoting blood circulation to remove blood stasis, dispelling wind and removing obstruction in the collateral, clearing away heat-damp and promoting diuresis, removing toxic substances.Housewife female's amenorrhea, dysmenorrhea, lochiostasis, lump in the abdomen, injury from falling down, rheumatic arthralgia, jaundice due to damp-heat, stranguria with turbid discharge leukorrhagia, sore swollen toxin, venom, burn due to hot liquid or fire.
Fructus Schisandrae Chinensis: base is former: be the dry mature fruit of magnoliaceae schisandra.The property of medicine: sour, sweet, temperature.Return lung, the heart, kidney channel.Function cures mainly: restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, and deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.
Herba Dendrobii: base is former: be the stem of orchid Dendrobium nobile or its multiple congener.Chemical analysis: Dendrobium nobile contains dendrobine, dendramine, Herba Dendrobii time alkali, dendroxine, dendrine, 6-hydroxydendroxine, still mucous matter, starch.Dendrobium moniliformeSweet is containing dendrobine, dendramine and N-methyl dendrobine (quaternary ammonium salt).Sieve river Herba Dendrobii is containing shihunine.The property of medicine: sweet, light, micro-salty, cold.Return stomach, lung, kidney channel.Function cures mainly: promote the production of body fluid stomach reinforcing, clearing away heat and nourishing YIN.Control consumption of body fluid caused by febrile disease, xerostomia excessive thirst, after being ill deficiency-heat, it is dark that the moon hinders order.
Rhizoma Polygonati Odorati: base is former: be the rhizome of liliaceous plant Rhizoma Polygonati Odorati.The property of medicine: sweet, flat.Attach to the lung and stomach meridians.Function cures mainly: nourishing YIN and moistening the lung, nourishing the stomach to promote the production of body fluid.Main cough caused by dryness, chronic cough, the dry throat and mouth of calentura cloudy liquid consumption wound, interior-heat is quenched one's thirst, deficiency of YIN diseases caused by exogenous pathogenic factor, dizzy dizzy, muscle arteries and veins spasm and pain.
Fructus Rubi: base is former: be the dry fruit of Rosaceae rubus rubus chingii Hu.The property of medicine: sweet, sour, temperature.Return kidney, urinary bladder channel.Function cures mainly: kidney tonifying, controlling nocturnal emission with astringent drugs, reducing urination.For enuresis due to deficiency of the kidney, frequent micturition, impotence and premature ejaculation, emission and spermatorrhea.
Semen Cuscutae: base is former: be the dry mature seed of convolvulus cuscuta plant.The property of medicine: sweet, temperature.Return liver,kidney,spleen warp.Function cures mainly: nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.For impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen is suffered from a deficiency of the kidney and is rushed down, externally treating leucoderma.
test example 1gained of the present invention helps digestion the clinical practice of lipid-lowering Chinese medicine preparation (embodiment 5): in May ,-2011 in May, 2009,284 routine hyperlipemias are screened in 4 hospitals, wherein male 154 example, women 130 example, oldest 68 years old, minimum 39 years old of age, 50 years old mean age, the most elder of the course of disease 11 years, the shortest person 5 months, average 5.5 years.Be divided into two groups at random, experimental group and matched group (often organizing 142 people).The situation no difference of science of statistics (P > 0.05) of two groups of patients in sex, age, the course of disease etc., has good comparability.
Tcm diagnosis standard:
(1) stagnation of turbid phlegm in middle-JIAO:
Syndrome: obesity, palpitation and dizziness, feeling of oppression and fullness in the chest and epigastrium, abdominal distension and anorexia, weak asthenia, nausea and salivation, feeling thirst but no desire to drink water, pale and corpulent tongue with indented margin, greasy fur, soft pulse.
(2) stagnation of liver-QI with deficiency of the spleen:
Syndrome: spirit depressing or being irritable and getting angry easily, forgetful insomnia, xerostomia anorexia or poor appetite, myasthenia of limbs, abdominal distention is just clear, pale tongue with white fur, stringy and thready pulse.
(3) deficiency of the liver and kidney: syndrome: have a dizzy spell, tinnitus is forgetful, insomnia and dreamful sleep, dry mouth and throat, soreness of the waist and knees, costalgia, dysphoria with feverish sensation in the chest palms and soles, the few tongue of red tongue, thready and rapid pulse.
(4) qi depression to blood stasis:
Syndrome: breast side of body feeling of distension and oppression, walks to alter pain or discomfort of feeling oppressed, irascible temperament, and the lower mass in the abdomen twinge tenderness of the side of body, purplish tongue is dark or see ecchymosis, deep and hesitant pulse.
Western medicine diagnose standard:
In normal diet situation, be >=6.0mmo1/L(230mg/dL as surveyed serum total cholesterol (TC) 2 times in 2 weeks) or triglyceride (TG) >=1.54mmo1/L(140mg/dL) or high density lipoprotein (HDL-C) male≤1.04mmol/L(40mg/dL), women≤1.17mmo1/L(45mg/dL) person, can make a definite diagnosis.Hyperlipoproteinemia five types be can be divided into by WHO standard, wherein hugely II a and II b, two hypotypes be divided again.
Therapeutic Method: experimental group uses gained of the present invention to help digestion lipid-lowering Chinese medicine preparation, using method: oral, every day twice, each 180mL, warm, within 20 days, be a course for the treatment of, treat two courses for the treatment of.Matched group uses the medicine (as chondroitin sulfate sheet, Simvastatin Tablets, fenofibrate micronized capsules, Elastase enteric coated capsule etc.) of conventional therapy hyperlipidemia, within 20 days, is a course for the treatment of, treats two courses for the treatment of.
Curative effect situation criterion: with reference to " new Chinese medicine guideline of clinical investigations (trying) ".Recovery from illness: clinical symptom disappearance, lipids detection result shows that TC declines >=40%, or TG declines >=40%; Effective: clinical symptoms disappears substantially, TC declines 30% ~ 39%, or TG declines 20% ~ 39%; Effective: clinical symptoms makes moderate progress, TC declines 10% ~ 29%, or TG declines 10% ~ 19%; Invalid: clinical symptoms is slightly improved or without improvement, lipids detection does not reach above-mentioned standard.Total effectively comprise recovery from illness and effective.After treating two courses for the treatment of, result is as shown in table 1.
Table 1: gained of the present invention helps digestion lipid-lowering Chinese medicine preparation compliance test result
Efficacy analysis: after two groups of cases treat two courses for the treatment of, experimental group cures 92 examples, effective 47 examples, and take a turn for the better 2 examples, invalid 1 example, total effective rate 97.89%; Matched group cures 42 examples, effective 54 examples, and take a turn for the better 33 examples, invalid 13 examples, total effective rate 67.61%.The clinical efficacy of experimental group is obviously better than matched group, and significant difference (P < 0.05), has statistical significance.
The present invention for instructing, carries out scientific composition with traditional Chinese medical science traditional theory, selects Radix Notoginseng, Radix Et Rhizoma Rhei, Fructus Amomi Rotundus and Rhizoma Typhonii etc. natural Chinese medicinal herb to be primary raw material, makes the lipid-lowering Chinese medicine preparation that helps digestion.Pseudo-ginseng hemostatic in side, loose blood, analgesic therapy.Radix Et Rhizoma Rhei purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.Fructus Amomi Rotundus removing dampness circulation of qi promoting, warming middle-JIAO to arrest vomiting, appetite-stimulating indigestion-relieving.Rhizoma Typhonii dispels the wind expectorant, the meridian dredging, removing toxic substances analgesia.Cortex Eucommiae invigorating the liver and kidney, bone and muscle strengthening, antiabortive.Fructus Leonuri blood circulation promoting and blood stasis dispelling, liver heat removing and eyesight improving.Radix Curcumae is invigorated blood circulation and stops energy, promoting QI circulation for relieving depression, the removing heat from blood that clears away heart-fire, depressed liver-energy dispersing and function of gallbladder promoting.Herba Taxilli invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, antiabortive.Semen arachidis hypogaeae herb tranquillizing and allaying excitement, reduces blood pressure.Fructus Ligustri Lucidi liver and kidney tonifying, clearind deficient heat, improving eyesight.The diuresis of Radix Camelliae sinensis heart tonifying, promoting blood flow to regulate menstruation, heat-clearing and toxic substances removing.Rhizoma Polygoni Cuspidati promoting blood circulation to remove blood stasis, dispelling wind and removing obstruction in the collateral, clearing away heat-damp and promoting diuresis, removing toxic substances.Fructus Schisandrae Chinensis convergence is astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.Herba Dendrobii promotes the production of body fluid stomach reinforcing, clearing away heat and nourishing YIN.Rhizoma Polygonati Odorati nourishing YIN and moistening the lung, nourishing the stomach to promote the production of body fluid.Fructus Rubi kidney tonifying, controlling nocturnal emission with astringent drugs, reducing urination.Semen Cuscutae nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.All medicines share, and have the effect such as blood circulation promoting and blood stasis dispelling, depressed liver-energy dispersing and function of gallbladder promoting, dispelling wind and removing obstruction in the collateral, kidney calming, the stomach reinforcing that promotes the production of body fluid, appetite-stimulating indigestion-relieving, clearing away heat-damp and promoting diuresis, nourishing the liver and kidney, promoting QI circulation for relieving depression, interior clearind deficient heat, the Bloodlipid-lowering that helps digestion is remarkable.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. help digestion a lipid-lowering Chinese medicine preparation, it is characterized in that, takes off the primary raw material medicine stating weight proportion and be prepared from: Radix Notoginseng 5-9, Radix Et Rhizoma Rhei (processed with wine) 6-8, Fructus Amomi Rotundus 8-12, Rhizoma Typhonii 9-13, Cortex Eucommiae 10-20, Fructus Leonuri 8-15, Radix Curcumae 7-14, Herba Taxilli 8-16, Semen arachidis hypogaeae herb 3-6, Fructus Ligustri Lucidi 9-12, Radix Camelliae sinensis 8-12, Rhizoma Polygoni Cuspidati 5-10, Fructus Schisandrae Chinensis 6-9, Herba Dendrobii 10-20, Rhizoma Polygonati Odorati 10-20, Fructus Rubi 9-16, Semen Cuscutae 9-12.
2. help digestion lipid-lowering Chinese medicine preparation as claimed in claim 1, it is characterized in that, takes off the primary raw material medicine stating weight proportion and be prepared from: Radix Notoginseng 6-8, Radix Et Rhizoma Rhei (processed with wine) 6.5-7.5, Fructus Amomi Rotundus 9-11, Rhizoma Typhonii 10-12, Cortex Eucommiae 13-17, Fructus Leonuri 10-12, Radix Curcumae 9-11, Herba Taxilli 11-13, Semen arachidis hypogaeae herb 3.5-5.5, Fructus Ligustri Lucidi 10-11.5, Radix Camelliae sinensis 9-11, Rhizoma Polygoni Cuspidati 7-9, Fructus Schisandrae Chinensis 7-8.5, Herba Dendrobii 14-16, Rhizoma Polygonati Odorati 13-16, Fructus Rubi 11-14, Semen Cuscutae 10-11.5.
3. help digestion lipid-lowering Chinese medicine preparation as claimed in claim 1, it is characterized in that, takes off the primary raw material medicine stating weight proportion and be prepared from: Radix Notoginseng 7, Radix Et Rhizoma Rhei (processed with wine) 7, Fructus Amomi Rotundus 10, Rhizoma Typhonii 11, the Cortex Eucommiae 15, Fructus Leonuri 11, Radix Curcumae 10, Herba Taxilli 12, Semen arachidis hypogaeae herb 4.5, Fructus Ligustri Lucidi 10.5, Radix Camelliae sinensis 10, Rhizoma Polygoni Cuspidati 8, Fructus Schisandrae Chinensis 7.5, Herba Dendrobii 15, Rhizoma Polygonati Odorati 14, Fructus Rubi 12, Semen Cuscutae 10.5.
4. the lipid-lowering Chinese medicine preparation that helps digestion as described in as arbitrary in claims 1 to 3, it is characterized in that, the lipid-lowering Chinese medicine preparation that this helped digestion makes pharmaceutically acceptable granule, and the preparation method of described granule is:
(1) clean Radix Et Rhizoma Rhei is got, add yellow wine to mix thoroughly, every 100kg Radix Et Rhizoma Rhei yellow wine 27-35kg(is every 100kg Radix Et Rhizoma Rhei yellow wine 33kg preferably), moistening 57-72 minute (preferred moistening 65 minutes), puts in pot, at the temperature of 105 DEG C-125 DEG C (under being preferable over the temperature of 118 DEG C), fry 14-20 minute (preferably frying 18 minutes), take out, cool, be ground into fine powder, cross No. five sieves;
(2) the saturated lime water of Rhizoma Typhonii is soaked 20-28 hour (preferably the saturated lime water of Rhizoma Typhonii being soaked 24 hours), every 100kg Rhizoma Typhonii quicklime 10-15kg(is every 100kg Rhizoma Typhonii quicklime 13kg preferably), take out, clear water is cleaned, and puts in food steamer, heat with high heat, steam 3.5-5.5 hour (preferably steaming 4.5 hours), take out, dry, be ground into fine powder, cross No. five sieves;
(3) Semen Cuscutae is loaded in gauze bag, marmite is put into all the other the 14 taste crude drug except Radix Et Rhizoma Rhei and Rhizoma Typhonii, decoct with water twice, amount of water is the 4.5-6.5 of the 15 taste crude drug gross weights added doubly (preferred amount of water is 5.5 times of the 15 taste crude drug gross weights added), each decoction 58-78 minute (preferably each decoction 68 minutes), filter, merging filtrate, is concentrated into the clear paste (being preferably concentrated into the clear paste of relative density 1.17) of relative density 1.11-1.19;
(4) step (3) gained clear paste and step (1) and step (2) gained fine powder are mixed, with fashion of extrusion by 12-20 eye mesh screen (preferably passing through 16 eye mesh screens with fashion of extrusion), make uniform granule, adopt fluid bed airpillow-dry, temperature controls at 60-65 DEG C, the water content control of granule within 2%, granulate subpackage and get final product.
5. the lipid-lowering Chinese medicine preparation that helps digestion as described in as arbitrary in claims 1 to 3, it is characterized in that, the lipid-lowering Chinese medicine preparation that this helped digestion makes pharmaceutically acceptable pill, and the preparation method of described pill is:
(1) clean Radix Et Rhizoma Rhei is got, add yellow wine to mix thoroughly, every 100kg Radix Et Rhizoma Rhei yellow wine 27-35kg(is every 100kg Radix Et Rhizoma Rhei yellow wine 33kg preferably), moistening 57-72 minute (preferred moistening 65 minutes), puts in pot, at the temperature of 105 DEG C-125 DEG C (under being preferable over the temperature of 118 DEG C), fry 14-20 minute (preferably frying 18 minutes), take out, cool, be ground into fine powder, cross No. five sieves;
(2) the saturated lime water of Rhizoma Typhonii is soaked 20-28 hour (preferably the saturated lime water of Rhizoma Typhonii being soaked 24 hours), every 100kg Rhizoma Typhonii quicklime 10-15kg(is every 100kg Rhizoma Typhonii quicklime 13kg preferably), take out, clear water is cleaned, and puts in food steamer, heat with high heat, steam 3.5-5.5 hour (preferably steaming 4.5 hours), take out, dry, be ground into fine powder, cross No. five sieves;
(3) all the other the 15 taste crude drug except Radix Et Rhizoma Rhei and Rhizoma Typhonii are ground into fine powder respectively, cross No. five sieves;
(4) step (1), step (2) and step (3) gained fine powder are fully mixed, with yellow wine (alcohol content 12-15%) general ball, to make diameter be the preferred diameter of 2-3mm(is 2.5mm) pill, adopt fluid bed airpillow-dry, temperature controls at 50-55 DEG C, and by the water content control of pill 4%.
6. the lipid-lowering Chinese medicine preparation that helps digestion as described in as arbitrary in claims 1 to 3, it is characterized in that, the lipid-lowering Chinese medicine preparation that this helped digestion makes pharmaceutically acceptable tablet, and the preparation method of described tablet is:
(1) clean Radix Et Rhizoma Rhei is got, add yellow wine to mix thoroughly, every 100kg Radix Et Rhizoma Rhei yellow wine 27-35kg(is every 100kg Radix Et Rhizoma Rhei yellow wine 33kg preferably), moistening 57-72 minute (preferred moistening 65 minutes), puts in pot, at the temperature of 105 DEG C-125 DEG C (under being preferable over the temperature of 118 DEG C), fry 14-20 minute (preferably frying 18 minutes), take out, cool, be ground into fine powder, cross No. five sieves;
(2) the saturated lime water of Rhizoma Typhonii is soaked 20-28 hour (preferably the saturated lime water of Rhizoma Typhonii being soaked 24 hours), every 100kg Rhizoma Typhonii quicklime 10-15kg(is every 100kg Rhizoma Typhonii quicklime 13kg preferably), take out, clear water is cleaned, and puts in food steamer, heat with high heat, steam 3.5-5.5 hour (preferably steaming 4.5 hours), take out, dry, be ground into fine powder, cross No. five sieves;
(3) Semen Cuscutae is loaded in gauze bag, marmite is put into all the other the 14 taste crude drug except Radix Et Rhizoma Rhei and Rhizoma Typhonii, decoct with water twice, amount of water is the 3.8-5.8 of the 15 taste crude drug gross weights added doubly (preferred amount of water is 4.8 times of the 15 taste crude drug gross weights added), each decoction 58-78 minute (preferably each decoction 70 minutes), filter, merging filtrate, is concentrated into the clear paste (being preferably concentrated into the clear paste of relative density 1.16) of relative density 1.09-1.21;
(4) step (3) gained clear paste and step (1) and step (2) gained fine powder are mixed, with fashion of extrusion by 12-20 eye mesh screen (preferably passing through 16 eye mesh screens with fashion of extrusion), make uniform granule, adopt fluid bed airpillow-dry, temperature controls at 50-55 DEG C, the water content control of granule within 2%, tabletting, the heavy 0.25g of every sheet, to obtain final product.
7. the lipid-lowering Chinese medicine preparation that helps digestion as described in as arbitrary in claims 1 to 3, it is characterized in that, the lipid-lowering Chinese medicine preparation that this helped digestion makes pharmaceutically acceptable decoction, and the preparation method of described decoction is:
(1) clean Radix Et Rhizoma Rhei is got, add yellow wine to mix thoroughly, every 100kg Radix Et Rhizoma Rhei yellow wine 27-35kg(is every 100kg Radix Et Rhizoma Rhei yellow wine 33kg preferably), moistening 57-72 minute (preferred moistening 65 minutes), puts in pot, at the temperature of 105 DEG C-125 DEG C (under being preferable over the temperature of 118 DEG C), fry 14-20 minute (preferably frying 18 minutes), take out, cool, be ground into fine powder, cross No. six sieves;
(2) the saturated lime water of Rhizoma Typhonii is soaked 20-28 hour, every 100kg Rhizoma Typhonii quicklime 10-15kg, take out, clear water is cleaned, and puts in food steamer, heats with high heat, steams 3.5-5.5 hour, takes out, dries, be ground into fine powder, crosses No. six sieves;
(3) Semen Cuscutae is loaded in gauze bag, marmite is put into all the other the 14 taste crude drug except Radix Et Rhizoma Rhei and Rhizoma Typhonii, add water, amount of water is 3.2-5.4 times (preferred amount of water is 4.5 times of the 15 taste crude drug gross weights added) of the 15 taste crude drug gross weights added, first boil with high heat to boiling, after continue to give slow fire boiling 30-42 minute (continuing to give slow fire boiling 35 minutes preferably), leach medicinal liquid;
(4) add water in the marmite filling medicinal residues, amount of water is 2.5-3.8 times (preferred amount of water is 3 times of the 15 taste crude drug gross weights added) of the 15 taste crude drug gross weights added, first boil with high heat to boiling, after continue to give slow fire boiling 28-38 minute (continuing to give slow fire boiling 33 minutes preferably), leach medicinal liquid;
(5) step (3) and step (4) gained medicinal liquid are merged, and step (1) and step (2) gained fine powder are added in the medicinal liquid after merging, to obtain final product.
8. help digestion the preparation method of lipid-lowering Chinese medicine preparation decoction as claimed in claim 7, it is characterized in that, in step (2), the saturated lime water of Rhizoma Typhonii is soaked 24 hours.
9. help digestion the preparation method of lipid-lowering Chinese medicine preparation decoction as claimed in claim 7, it is characterized in that, every 100kg Rhizoma Typhonii quicklime 13kg in step (2).
10. help digestion the preparation method of lipid-lowering Chinese medicine preparation decoction as claimed in claim 7, it is characterized in that, steams 4.5 hours in step (2).
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1156601A (en) * | 1996-02-08 | 1997-08-13 | 袁克兴 | Blood-fat reducing medicine and preparing process thereof |
| JP2008063246A (en) * | 2006-09-05 | 2008-03-21 | Ryukyu Bio Resource Kaihatsu:Kk | Composition containing fermented blasted dietary fiber |
| CN102886038A (en) * | 2012-10-15 | 2013-01-23 | 王彦进 | Traditional Chinese medicine preparation for losing weight and preparation method of traditional Chinese medicine preparation |
-
2015
- 2015-02-09 CN CN201510063105.6A patent/CN104547958A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1156601A (en) * | 1996-02-08 | 1997-08-13 | 袁克兴 | Blood-fat reducing medicine and preparing process thereof |
| JP2008063246A (en) * | 2006-09-05 | 2008-03-21 | Ryukyu Bio Resource Kaihatsu:Kk | Composition containing fermented blasted dietary fiber |
| CN102886038A (en) * | 2012-10-15 | 2013-01-23 | 王彦进 | Traditional Chinese medicine preparation for losing weight and preparation method of traditional Chinese medicine preparation |
Non-Patent Citations (9)
| Title |
|---|
| 倪鸿翔等: "三七大黄饮治疗单纯性肥胖症14例", 《安徽中医学院学报》 * |
| 曾强: "《家庭保健药茶配制》", 31 January 2002 * |
| 朱秋玲等: "中西医结合治疗高血脂症80例", 《江西中医药》 * |
| 李廷荃: "《高血脂防治随身书》", 30 April 2014 * |
| 樊岚岚: "《中草药的养生智慧》", 30 April 2012 * |
| 王忠良: "《降血压降血脂吃什么宜忌速查》", 31 March 2013 * |
| 谭波等: "三降胶囊调脂对冠心病二级预防的临床研究", 《山东中医杂志》 * |
| 赵雪梅等: "《高脂血症合理用药270问》", 30 September 2013 * |
| 马汴梁: "《排毒养颜茶酒方》", 28 February 2014 * |
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