CN104540297A - Stroboscopic dimming device for animal experiments - Google Patents
Stroboscopic dimming device for animal experiments Download PDFInfo
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- CN104540297A CN104540297A CN201510007642.9A CN201510007642A CN104540297A CN 104540297 A CN104540297 A CN 104540297A CN 201510007642 A CN201510007642 A CN 201510007642A CN 104540297 A CN104540297 A CN 104540297A
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- stroboscopic
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02B—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO BUILDINGS, e.g. HOUSING, HOUSE APPLIANCES OR RELATED END-USER APPLICATIONS
- Y02B20/00—Energy efficient lighting technologies, e.g. halogen lamps or gas discharge lamps
- Y02B20/40—Control techniques providing energy savings, e.g. smart controller or presence detection
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Abstract
The invention relates to a stroboscopic dimming device for animal experiments. The stroboscopic dimming device is provided with stroboscopic dimmers. Each stroboscopic dimmer comprises a power switch, a power fuse, a frequency dimmer, a brightness dimmer, a work and rest setting device and a stroboscopic setting device. The frequency regulation range of the frequency dimmers is 0-5 Hz; the brightness peak value of the brightness dimmers is 600 lux, and the brightness valley value of the brightness dimmers is 0 lux; one end of each stroboscopic dimmer is connected with LEDs on a rearing cage, and the other end of each stroboscopic dimmer is connected with a time control switch; the rearing cages are each provided with four LEDs. The stroboscopic dimming device has the advantages that stroboscopic light different in frequency, brightness and cycle can be simulated through combined application of the control elements, and then the effect on myopia development by all parameters of the stroboscopic light can be effectively studied; the stroboscopic dimming device is simple and convenient to use, small in side effect and capable of making indirect contact with experimental animals, thereby being high in safety.
Description
Technical field
The present invention relates to technology zoopery instrument field, specifically, is a kind of zoopery stroboscopic light modulating device.
Background technology
Only important natural phenomena, why the mankind can see scene variegated, fast changing in objective world, are because eyes accept the light of object emission, reflection or scattering.The visual stimulus that vision system obtains from nature can be roughly divided into three classes: light sensation (perceptual object light and shade), shape feel (perceptual object shape and contrast) and colour vision (perceptual object color).
At present, the cause of disease of myopia remains a global difficult problem, and in recent decades in myopia research a large breakthrough successfully establishing near-sighted animal model 20th century exactly, and on animal model, obtain some achievements in research about development of myopia mechanism, further illustrate the mechanism of development of myopia.Apply near-sighted Research of Animal Model for Study myopia and there is lot of advantages, such as some research cannot carried out on human body can be moved on animal and carry out.The foundation of animal model makes the further investigation of myopia become possibility, and provides animal basis for the medicine of the new retarding myopia progression of Future Development.
Namely 1, ultrastructure in form deprivation myopia the Research of Animal Model for Study of myopia establishes two kinds of experimental models, refers to sewing up eyelid, wears disperse eyeglass or headgear method and feels to the simple eye shape of destroying animal the myopia caused; 2, eyeglass inductivity myopia, or claim lens-induced myopia, refer to force animal myopia or wear negative spherical lens make the image focu of object in retina rear, thus cause accommodative excess and axis oculi to extend, the myopia caused.Although form deprivation and optical defocus also exist difference in essence between the two, but only find the difference in some phenomenons up to now, to illustrate difference place complete and basic between two kinds of induction modes from mechanism, still needing will the difference phenomenon of further both comparative study on the basis setting up myopia model.
The experiment method of employing is depended in different plant species experiment modeling success or not to a great extent, and form deprivation and the classical induction myopia animal model of optical defocus these two kinds all have some shortcomings part.The near-sighted abductive approach being usually used at present testing comprises eyelid suture, eyeglass induction, semi-transparent film etc., and these methods all exist shortcoming to a certain degree.Such as, although eyelid suture be a kind of classics effectively, widely accepted method, also have obvious shortcoming: suture easily comes off, once suture comes off, this animal used as test just has to be excluded away, causes animal usage quantity to increase, and experiment difficulty increases; Eyelid suture has traumatic, easily causes ocular infection; Eyelid suture may oppress cornea also can affect corneal curvature, thus affects experimental result; In addition, eyelid suture is irreversible, and after suture removal, long stitching can cause eyelid to stick together, and be difficult to form Restoration model, and the stitching of the normal employing of eyeglass induction or adhesion eyeglass also exists similar shortcoming too.Have research to attempt performing the operation at the up cornea refractive surgery of animal corneal such as PRK, to set up LIM animal model, but the model post-operative cornea that the method is set up easily infects, and cannot set up convalescence model, can not observe convalescent change.
The shape that the Form Deprived Myopia that success has been set up at present has mainly blocked in normal vision is felt, and on scioptics change retina, the optical defocus myopia of the contrast induction of imaging also can think a kind of form deprivation of special shape in essence.In recent years, colour vision is paid attention to the relation of myopia, and the myopia model of initiation that colour vision is unbalance is successfully set up.But, as the light sensation of fundamental position the most in the large key element of visually-perceptible three, there is no a kind of universally recognized photosensitive feel abnormality myopia model.
And up to now, any one artificial light equipment, all cannot accomplish the simulation completely to available light.As a kind of abnormal visual experience, due to the comparison of light and shade that strobe light itself is strong, without form deprivation and colour vision unbalance factor in During Illumination, because of but a kind of special photoparesthesia environment.Due to strobe light change is light sensation the most basic in visually-perceptible, and the influence value for eyeball development obtains to be studied further.
In sum, need the abnormal luminous environment of a kind of simulation badly, can the frequency of free adjustment strobe light, brightness and cycle strobe stroboscopic light modulating device, make it to further investigate the strong change of this time contrast of strobe light and photoparesthesia to the impact of myopia model animal.
Summary of the invention
The object of the invention is for deficiency of the prior art, there is provided a kind of simulation abnormal luminous environment, can the frequency of free adjustment strobe light, brightness and cycle strobe stroboscopic light modulating device, make it to further investigate the strong change of this time contrast of strobe light and photoparesthesia to the impact of myopia model animal.
For achieving the above object, the technical scheme that the present invention takes is:
A kind of zoopery stroboscopic light modulating device, described stroboscopic light modulating device is provided with stroboscopic dimmer, and described stroboscopic dimmer comprises mains switch, power safety, frequency dimmer, brightness dimmer, work and rest setting apparatus, stroboscopic setting apparatus; The frequency-tuning range of described frequency dimmer is 0-5Hz; Described brightness dimmer brightness peak is 600lux, and valley is 0lux; Described stroboscopic dimmer one end is connected with the light-emitting diode on rearging cage, and the other end connects time switch; Described rearging cage is also provided with gobo; Described rearging cage is equipped with four Light-Emitting Diodes, and four Light-Emitting Diodes all connect a stroboscopic dimmer, the corresponding rearging cage of each stroboscopic dimmer; Connection time switch unified by described frequency dimmer, and described time switch is connected on the power supply of 220V.
Described stroboscopic setting apparatus and work and rest setting apparatus chronomere comprise 0.1 second, second, point, time, setting-up time scope is 0 second-999 hours.
Described work and rest setting apparatus comprises operation setup device and rest setting apparatus; Described stroboscopic setting apparatus comprises high light setting apparatus and low light level setting apparatus.
Described operation setup device, rest setting apparatus, high light setting apparatus, low light level setting apparatus are all made up of four keys, and wherein three keys are numerical key, and another one key is chronomere's key.
Described Light-Emitting Diode is fixed on height 40cm place, rearging cage corner by thin wire.
Described frequency dimmer regulating frequency is 5Hz, 1Hz, 0.5Hz, 0.25Hz, 0.1Hz, 0Hz.
Described brightness dimmer brightness regulation scope is 0-300lux, 0-600lux, 300-600lux.
Separate between described rearging cage, long for 50cm, wide be 50cm, high be 50cm.
The invention has the advantages that:
1, a kind of zoopery stroboscopic light modulating device of the present invention, strobe light stimulates the myopia model produced compared with traditional form deprivation and optical defocus myopia model, and more simple and convenient, side effect is less.Because this stroboscopic light modulating device is the myopia model caused by abnormal luminous environment, with animal used as test non-direct contact, fail safe is higher, and during our observation experiment, the exception of appetite and behavior aspect does not appear in cavy because of the stimulation of strobe light, therefore in modeling, has larger advantage;
2, compared with the strobe light adopted with other correlative study, stroboscopic light modulating device of the present invention, by the Combination application of control element, different frequency, brightness and the strobe light in cycle can be simulated, and then effectively can study each parameter of strobe light to the effect of development of myopia;
3, the comparison of light and shade that strobe light itself is strong, in During Illumination without form deprivation or colour vision unbalance, experimental result is accurate, hurtless measure.
Accompanying drawing explanation
Accompanying drawing 1 is a kind of zoopery stroboscopic light modulating device structural representation of the present invention.
Accompanying drawing 2 is a kind of stroboscopic dimmer configuration schematic diagrames of the present invention.
Accompanying drawing 3 is structural representations of a kind of zoopery stroboscopic light modulating device simulation different frequency of the present invention.
Accompanying drawing 4 is structural representations that a kind of zoopery stroboscopic light modulating device of the present invention simulates different brightness.
Embodiment
Below in conjunction with accompanying drawing, embodiment provided by the invention is elaborated.
The Reference numeral related in accompanying drawing and part as follows:
1. stroboscopic dimmer 11. mains switch
12. power safety 13. frequency dimmers
14. brightness dimmers 15. are worked and rested setting apparatus
151. operation setup device 152. rest setting apparatus
16. stroboscopic setting apparatus 161. high light setting apparatus
162. low light level setting apparatus 2. rearging cages
21. gobo 3. time switchs
Embodiment 1
Please refer to Fig. 1, Fig. 1 is a kind of zoopery stroboscopic light modulating device structural representation of the present invention.Described stroboscopic light modulating device is provided with stroboscopic dimmer 1; Described stroboscopic dimmer 1 one end is connected with the light-emitting diode on rearging cage 2, and the other end connects time switch 3; Separate between described rearging cage 2, long for 50cm, wide be 50cm, high be 50cm; Described rearging cage 2 is also provided with gobo 21; Described rearging cage 2 is equipped with four Light-Emitting Diodes, and four Light-Emitting Diodes all connect a stroboscopic dimmer 1, the corresponding rearging cage 2 of each stroboscopic dimmer 1, first measures the brightness of rearging cage 2 intraoral illumination by illuminance meter before experiment; Described Light-Emitting Diode is fixed on rearging cage 2 four jiaos of height 40cm places by thin wire; Described frequency dimmer 1 unified connection time switch 3; Described time switch 3 is connected on the power supply of 220V.
Please refer to Fig. 2, Fig. 2 is a kind of stroboscopic dimmer configuration schematic diagram of the present invention.Described stroboscopic dimmer 1 comprises mains switch 11, power safety 12, frequency dimmer 13, brightness dimmer 14, work and rest setting apparatus 15, stroboscopic setting apparatus 16; The chronomere of described stroboscopic setting apparatus 16 and work and rest setting apparatus 15 comprises 0.1 second, second, point, time, setting-up time scope is 0 second-999 hours; Described work and rest setting apparatus 15 comprises operation setup device 151 and rest setting apparatus 152; Described stroboscopic setting apparatus 16 comprises high light setting apparatus 161 and low light level setting apparatus 162; Described operation setup device 151, rest setting apparatus 152, high light setting apparatus 161, low light level setting apparatus 162 are all made up of four keys, and wherein three keys are numerical key, and another one key is chronomere's key (not shown).
Please refer to Fig. 3, Fig. 3 is the structural representation of a kind of zoopery stroboscopic light modulating device simulation different frequency of the present invention.The frequency-tuning range of described frequency dimmer 13 is 0-5Hz, and in the present embodiment, optimized frequency is that 5Hz, 1Hz, 0.5Hz, 0.25Hz, 0.1Hz, 0Hz regulate; The strobe light of different frequencies simulated by described stroboscopic dimmer 1, and unification is controlled by a time switch 3.
Please refer to Fig. 4, Fig. 4 is the structural representation that a kind of zoopery stroboscopic light modulating device of the present invention simulates different brightness.Described brightness dimmer 14 brightness peak is 600lux, and valley is 0lux, and in the present embodiment, preferred brightness range is that 0-300lux, 0-600lux, 300-600lux regulate; The strobe light of different brightness simulated by described brightness dimmer 14, and unification is controlled by a time switch 3.
It should be noted that: described work and rest setting apparatus 15 comprises operation setup device 151 and rest setting apparatus 152, operation setup time is used for arranging operating time, rest setting apparatus 152 for setting the time of having a rest, wherein, the numerical value set in the power-off state is only had to be only effectively, if need modification time during work, turn off power supply, reset and be energized, new arranging just comes into force; Described frequency dimmer 13 regulates the photoenvironment of different frequency, saves into square wave according to frequency-adjustable, can zoologize at different frequency photoenvironment on eye shaft length and dioptric impact; Described brightness dimmer 14 may be adjusted to the photoenvironment of high light and the low light level, the cellula visualis can zoologizeed under high light and the low light level, cellula visualis has a kind of rhodopsin, it is a kind of protein of combination, can resolve into rapidly albumen and retinene when illumination, its reaction is a multistage reaction, under high light, resolve into rhodopsin, synthesize again under the low light level, by reaction balance point so that studying physiological structure is on the impact of animal myopia; Described stroboscopic setting apparatus 16 can control time and the low light irradiation time of strong illumination, zoologizes further within a certain period of time, on the impact of animal eyes under strong illumination or under low light irradiation; Described time switch 3 is for controlling each stroboscopic dimmer 1, so that its each experimental group improve parameter unification; Described cage tool interlayer is equipped with stainless steel separator for receiving animal excrements, and dividing plate rinses every day in time.Described gobo 21, between each rearging cage 2, is guaranteed not by external environmental interference, and the omnidistance sub-cage rearing of all animals is at the standardization feeding room of central laboratory, the shading of receptacle darkroom, room ventilation is good, and indoor temperature controls at 20 ~ 22 DEG C, relative humidity 55 ~ 65%.
The experimental technique of a kind of zoopery stroboscopic light modulating device of the present invention is: first, suppose that experimental study object is cavy, preferably four groups of cavys, often organize 12, be labeled as I group, II group, III group, IV group, four groups of cavys are inserted in four rearging cages 2, connects stroboscopic dimmer 1, and each stroboscopic dimmer 1 is controlled by a total time switch 3; Then regulate the parameter of stroboscopic dimmer 1, be preferably: the stroboscopic dimmer 1 of stroboscopic dimmer 1 regulating frequency of I group of cavy, II group of cavy regulates brightness, the stroboscopic dimmer 1 of III group of cavy sets the time cycle under strong illumination, the stroboscopic dimmer 1 of IV group of cavy sets time cycle under low light irradiation; After certain hour, study its cavy in the impact of different light environment on hypometropia.
A kind of zoopery stroboscopic light modulating device of the present invention, strobe light stimulates the myopia model produced compared with traditional form deprivation and optical defocus myopia model, and more simple and convenient, side effect is less.Because this stroboscopic light modulating device is the myopia model caused by abnormal luminous environment, with animal used as test non-direct contact, fail safe is higher, and during our observation experiment, the exception of appetite and behavior aspect does not appear in cavy because of the stimulation of strobe light, therefore in modeling, has larger advantage; Compared with the strobe light adopted with other correlative study, stroboscopic light modulating device of the present invention, by the Combination application of control element, different frequency, brightness and the strobe light in cycle can be simulated, and then effectively can study each parameter of strobe light to the effect of development of myopia; The comparison of light and shade that strobe light itself is strong, in During Illumination without form deprivation or colour vision unbalance, experimental result is accurate, hurtless measure.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the prerequisite not departing from the inventive method; can also make some improvement and supplement, these improve and supplement and also should be considered as protection scope of the present invention.
Claims (8)
1. a zoopery stroboscopic light modulating device, is characterized in that, described stroboscopic light modulating device is provided with stroboscopic dimmer, and described stroboscopic dimmer comprises mains switch, power safety, frequency dimmer, brightness dimmer, work and rest setting apparatus, stroboscopic setting apparatus; The frequency-tuning range of described frequency dimmer is 0-5Hz; Described brightness dimmer brightness peak is 600lux, and valley is 0lux; Described stroboscopic dimmer one end is connected with the light-emitting diode on rearging cage, and the other end connects time switch; Described rearging cage is also provided with gobo; Described rearging cage is equipped with four Light-Emitting Diodes, and four Light-Emitting Diodes all connect a stroboscopic dimmer, the corresponding rearging cage of each stroboscopic dimmer; Connection time switch unified by described frequency dimmer; Described time switch is connected on the power supply of 220V.
2. stroboscopic light modulating device according to claim 1, is characterized in that, described stroboscopic setting apparatus and work and rest setting apparatus chronomere comprise 0.1 second, second, point, time, setting-up time scope is 0 second-999 hours.
3. stroboscopic light modulating device according to claim 1, is characterized in that, described work and rest setting apparatus comprises operation setup device and rest setting apparatus; Described stroboscopic setting apparatus comprises high light setting apparatus and low light level setting apparatus.
4. stroboscopic light modulating device according to claim 3, is characterized in that, described operation setup device, rest setting apparatus, high light setting apparatus, low light level setting apparatus are all made up of four keys, and wherein three keys are numerical key, and another one key is chronomere's key.
5. stroboscopic light modulating device according to claim 1, is characterized in that, described Light-Emitting Diode is fixed on height 40cm place, rearging cage corner by thin wire.
6. stroboscopic light modulating device according to claim 1, is characterized in that, described frequency dimmer regulating frequency is 5Hz, 1Hz, 0.5Hz, 0.25Hz, 0.1Hz, 0Hz.
7. stroboscopic light modulating device according to claim 1, is characterized in that, described brightness dimmer brightness regulation scope is 0-300lux, 0-600lux, 300-600lux.
8. stroboscopic light modulating device according to claim 1, is characterized in that, separate between described rearging cage, long for 50cm, wide be 50cm, high be 50cm.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510007642.9A CN104540297A (en) | 2015-01-08 | 2015-01-08 | Stroboscopic dimming device for animal experiments |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510007642.9A CN104540297A (en) | 2015-01-08 | 2015-01-08 | Stroboscopic dimming device for animal experiments |
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| CN104540297A true CN104540297A (en) | 2015-04-22 |
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| CN201510007642.9A Pending CN104540297A (en) | 2015-01-08 | 2015-01-08 | Stroboscopic dimming device for animal experiments |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107981837A (en) * | 2017-12-06 | 2018-05-04 | 中国科学院昆明动物研究所 | A kind of comparative study method that lighting source develops Macaque of Macaca axis oculi |
| CN111587841A (en) * | 2020-05-20 | 2020-08-28 | 浙江维通利华实验动物技术有限公司 | Method for breeding experimental rats and mice by specific spectrum lighting system |
| CN113412792A (en) * | 2021-07-12 | 2021-09-21 | 温州眼视光国际创新中心 | Myopia animal model construction instrument |
| CN113519405A (en) * | 2021-08-12 | 2021-10-22 | 北京京德嘉润视觉科技股份有限公司 | Close-range feeding environment simulation equipment for mammals |
Citations (2)
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| GB2196442A (en) * | 1986-10-16 | 1988-04-27 | Duncan John Anderson | Portable stroboscope having separate light sources for each eye |
| CN1711057A (en) * | 2002-11-14 | 2005-12-21 | 昆士兰科技大学 | A method or apparatus for inhibiting myopia development in humans |
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2015
- 2015-01-08 CN CN201510007642.9A patent/CN104540297A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2196442A (en) * | 1986-10-16 | 1988-04-27 | Duncan John Anderson | Portable stroboscope having separate light sources for each eye |
| CN1711057A (en) * | 2002-11-14 | 2005-12-21 | 昆士兰科技大学 | A method or apparatus for inhibiting myopia development in humans |
Non-Patent Citations (1)
| Title |
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| 邸悦: "频闪光诱导光觉异常性豚鼠近视模型", 《中国实验动物学报》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107981837A (en) * | 2017-12-06 | 2018-05-04 | 中国科学院昆明动物研究所 | A kind of comparative study method that lighting source develops Macaque of Macaca axis oculi |
| CN107981837B (en) * | 2017-12-06 | 2020-04-28 | 中国科学院昆明动物研究所 | Comparative research method for yangtao axis development of macaca by using illumination light source |
| CN111587841A (en) * | 2020-05-20 | 2020-08-28 | 浙江维通利华实验动物技术有限公司 | Method for breeding experimental rats and mice by specific spectrum lighting system |
| CN113412792A (en) * | 2021-07-12 | 2021-09-21 | 温州眼视光国际创新中心 | Myopia animal model construction instrument |
| CN113519405A (en) * | 2021-08-12 | 2021-10-22 | 北京京德嘉润视觉科技股份有限公司 | Close-range feeding environment simulation equipment for mammals |
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Inventor after: Di Yue Inventor after: Zeng Daling Inventor after: Lu Na Inventor after: Zhou Xiaodong Inventor after: Zhou Xingtao Inventor after: Qiao Tong Inventor after: Chen Zhi Inventor after: Liu Rui Inventor after: Li Bing Inventor after: Luo Xiumei Inventor before: Di Yue Inventor before: Lu Na Inventor before: Zhou Xiaodong Inventor before: Li Bing Inventor before: Zeng Daling |
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Application publication date: 20150422 |