CN104537265B - A kind of method, system and the equipment of intelligence computation personalization rational use of medicines time - Google Patents

Abstract

The present invention provides the method for intelligence computation personalization rational use of medicines time a kind of, which comprises establishes drug and uses time correlation multidimensional attribute item dictionary；Drug is extracted using time correlation element information；Drug is handled using time correlation element information various dimensions；Drug is set using time priority rank；Patient medication relevant factor information extraction；The processing of patient medication relevant factor information various dimensions；Patient's daily schedule sets；The single drug rational use of medicines time generates；Patient's entirety drug rational use of medicines time schemes generation.By implementing intelligent medication guide method, system and equipment of the invention, magnanimity administration data can be analyzed and handled with application message technology, intelligentized medication guide mode is provided.

Description

A kind of method, system and the equipment of intelligence computation personalization rational use of medicines time

Technical field

The present invention relates to the technical fields of intelligent medication information processing, more particularly to a kind of intelligence computation individual character chemical combination Manage method, system and the equipment of administration time.

Background technique

Every physiological function of human body is controlled by the adjusting of the natural rhythm and pace of moving things and biological clock, with certain division of day and night rule.Disease The development of disease, because the physiological function change with human body has substantial connection, also usually has stronger division of day and night rule with performance.Drug Absorption, metabolism, working equally has with the physiological function change of human body and closely contacts, therefore also with certain division of day and night rule Rule.

The division of day and night correlation for fully considering human body, disease, drug, in conjunction with the respective temporal regularity of three, according to different Patient, disease, drug design reasonable administration time, drug can be made to play a role in Best Times, effectively control disease, And drug dosage and adverse drug reaction are reduced as far as possible, while can also reach and improve patient medication compliance Purpose, thus promote safely, effectively, economic, the convenient rational use of medicines.

But because the temporal correlation between human body, disease, drug is extremely complex, especially suffered from simultaneously in patient A variety of diseases or simultaneously using in the case where a variety of drugs, only rely on the manual analysis of doctor or pharmacist, it is difficult to consider comprehensively Correlative factor, the most reasonable administration time scheme of rapid development.Application message technology is established and uses temporal database comprising drug And drug uses the information system of time computation model, and doctor, pharmacist and sufferers themselves can be helped to analyze patient comprehensively The correlation of various drugs used and human body, disease division of day and night rule formulates the administration time scheme of optimization, ensures that patient is reasonable Medication.

Summary of the invention

The present invention provides method, system and the equipment of a kind of intelligence computation personalization rational use of medicines time.

A kind of method of intelligence computation personalization rational use of medicines time, which is characterized in that the described method includes:

It establishes drug and uses time correlation multidimensional attribute item dictionary；

Drug is extracted using time correlation element information；

Drug is handled using time correlation element information various dimensions；

Drug is set using time priority rank；

Patient medication relevant factor information extraction；

The processing of patient medication relevant factor information various dimensions；

Patient's daily schedule sets；

The single drug rational use of medicines time generates；

Patient's entirety drug rational use of medicines time schemes generation.

Record, analysis and the report of the practical administration time of patient.

Preferably, this method further comprises, drug uses time correlation multidimensional attribute item dictionary, is used according to drug The medicine or pharmacological properties structure of time and relevant factor and each attribute definition are established.

Preferably, this method further comprises, drug uses time correlation multidimensional attribute item dictionary, for providing drug The normal dictionary being related to drug using the every medicine or pharmacological properties of time correlation in use information and patient medication information.

Preferably, this method further comprises, drug uses time correlation multidimensional attribute item dictionary, for providing drug In use information and patient medication information with drug using time correlation every medicine or pharmacological properties separate sources different name with Normal dictionary incidence relation.

Preferably, this method further comprises, drug uses time and relevant factor database, uses the time according to drug It is established with the corresponding relationship of relevant factor information.

Preferably, this method further comprises, drug uses medicine attribute involved in time and relevant factor database Item includes at least: crowd's association attributes of patient, the special population association attributes of patient, the disease association attributes of patient, patient Medical history association attributes, the operation association attributes of patient, patient personal lifestyle history association attributes etc. wherein at least one A dimension.

Preferably, this method further comprises, drug uses pharmacological properties involved in time and relevant factor database It includes at least: medication purpose association attributes, patient of hypersensitivity's history association attributes, patient medication history association attributes, patient medication The wherein at least one dimension of administration route association attributes, patient medication related gene attribute etc..

Preferably, this method further comprises, drug uses time correlation involved in time and relevant factor database Attribute item includes at least: such as with natural rhythm and pace of moving things correlation time attribute: year, month, day, in the daytime/night, the morning/morning/noon/under Noon/night/night, season etc.；Such as with correlation time in division of day and night attribute: hour, minute；When related to individual's work and rest rule of life Between attribute such as: get up, before the meal/meal in/it is postprandial, sleep before；Such as with the state of an illness/symptom/index correlation time attribute: body temperature is more than ... When spending, when pain, when dizziness, when nervous, when nausea etc.；Such as with patient's inspection/operation/operation correlation time attribute: before inspection, After operation, when dressing；Time attribute relevant to patient's physiological period is such as: menstruation first day, menopause later six months；It is raw with patient Educate relevant time attribute such as: 24 hours after man and wife's the same branch of a family, 3 days after preparing before being pregnant March, being pregnant 24 weeks, produce；With patient Work/activity correlation time attribute is such as: the wherein at least one dimension before by bus, before high-altitude application.

Preferably, this method further comprises, drug uses time and relevant factor database, is capable of providing two or more The dictionary for needing patient's separated in time to use between drug, including but not limited to: existing because between drug interaction needs Every make the time the case where, Chinese and western drugs are used together between the case where needing interval time, drug needs containing identical/similar component Want interval time using the case where and other need the case where being spaced between drug using the time.

Preferably, this method further comprises, drug uses time and relevant factor database, can be according to each drug Using time and relevant factor information to patient safety, effective, economy, the significance level for being convenient to use drug, carry out preferential The setting of rank.

Preferably, this method further comprises, the step of patient personalized rational use of medicines time schemes generation, according to patient Daily schedule and patient used in drug rational use of medicines time scheme, generate and meet the personalized of patient real life rule and use Medicine time scheme.

Preferably, this method further comprises, the administration time that doctor, pharmacist or sufferers themselves can automatically generate in upper step On the basis of scheme, result audit and adjustment are carried out to patient personalized administration time scheme.

Preferably, this method further comprises, according to patient personalized administration time scheme and setting is reminded, system can determine When remind patient use drug.

Preferably, this method further comprises, based on mobile phone, intelligent wearable device, intelligent medicine box, intelligent medicine box, The application of the plurality of devices such as call center, wechat, short message, doctor/pharmacists ' job station is supported.

Preferably, this method further comprises, patient's rational use of medicines time scheme is in doctor, pharmacist, nursing staff, family members Data interaction between patient all can get effective, timely medication prompting to guarantee patient under various conditions.

Preferably, this method further comprises, the record of the patient medication time practical executive condition of scheme and related report The generation of table, so as to doctor, pharmacist, reasonable personnel and sufferers themselves analysis, adjustment and optimization treatment plan.

Preferably, this method further comprises, drug derives from package insert, medicine using time correlation element information Allusion quotation, national formulary, treatment/medicine guide, Consensus of experts and medical institutions' medication at different levels regulation etc. wherein at least it One.

Preferably, this method further comprises, patient medication relevant information is extracted, correlation category when for extracting patient medication The actual information of property element.

Preferably, this method further comprises, the source of patient medication information is doctor formula, therapeutic scheme, uses prescription Case, case history, medical record, medicine go through, inspection result, patient's readme symptom, patient independently select medicine etc. at least one of wherein.

Preferably, this method is applied to C/S framework or B/S framework.

Preferably, generating the mode of intelligent medication guide result are as follows:

Patient medication relevant information is obtained, including,

Certain patient basis: age, gender, weight ...

Disease information: diagnosis, symptom, index, operation/operation, medical history ...

Medication information: prescription drug, with drug, drug allergy history ...

Other information: season, weather, pandemic ...

Certain patient (Patient, abbreviation Pa), essential information include age (age, abbreviation ag), gender (gender, abbreviation Gen), affiliated special population (special, abbreviation spe).Disease information includes diagnosis (diagnose, abbreviation dia), symptom (symptom, abbreviation sym), index (index, abbreviation ind), operation/operation (operation, abbreviation opr), medical history (history disease, abbreviation his).

Medication information includes prescription drug (prescription drug, abbreviation predrug), with drug (in use Drug, abbreviation usedrug), drug allergy history allergic history, abbreviation ale.

Other environmental information includes season (season abbreviation sesn), weather (Climate abbreviation cli), pandemic (Epidemic abbreviation Epi).

Essential information Pa (ag, gen, spe)=GetPatientBase () of patient；

Patient disease information Pa (dia, sym, ind, opr, his)=GetPatientDisease ()；

Patient medication information Pa (predrug, userug, ale)=GetPatientDrugInfo ()；

Current other information Env (sesn, cli, epi)=GetEnvironmentInfo ()；

The overall medication information Pa (info) of patient=Pa (ag, gen, spe) ∪ Pa (dia, sym, ind, opr, his) ∪ Pa(predrug,userug,ale)∪Env(sesn,cli,epi)

According to patient prescription's drug, in the administration time model for extracting related drugs from " administration time database " with drug It encloses.

The prescription drug of patient and be Med1, Med2 ..., Medn with drug, administration time range is Med_i (Time)=GetMedTime (Medi)；

Patient medication information is compareed with the applicable elements of every administration time of above-mentioned drug label, summarizes applicable item Part marks the administration time being consistent with the patient medication information, generates the rational use of medicines time model of various drugs used in the patient It encloses.

Certain Patient drug Med_iRational use of medicines time range be Med_i(Time)。

The element info of certain medication guide of this drug_k, medication information matches result with the patient are as follows:

The rational use of medicines time of this drug and the state of an illness matching result of the patient are as follows:

For some drug Med of patient Pa_i, the rational use of medicines time is Time (Pa, Med_i)=Med_i(Inst_j)*G (Pa, Med_i(Time))

Setting for the priority level of the data and each administration time that use is spaced according to the needs between various drugs Fixed, the setting of patient's daily schedule ultimately generates the reasonable administration time scheme of patient.

For the patient, for this drug Med_i, best medication time is Time (Pa, Med_i).Drug Med_iWith Med_j's Time interval is T, and priority ranking weight is y_i。

In conjunction with the clear time range that the drug division of day and night is learned, for drug Med_i, the medication frequency issued for certain specific prescription Rate f, in conjunction with the daily life daily schedule Pa (livetime) of patient, the medication Best Times range of the drug is Med_i(z₁, z₂... z_f), (z is time range, such as z₁=(7:30am, 8:00am), z₂=(12:30am, 1:00pm), z₃=(6:30pm, 7:00pm))。

Medication time of this patient about prescription Pre

Time (Pa, Pre, Med₁, Med₂..., Med_n)

=Med₁(z₁, z₂... z_f)∩Med₂(z₁, z₂... z_f)...

∩Med_n(z₁, z₂... z_f)

Wherein, Interval (Med_i, Med_j) < T (Med_i, Med_j), the time priority of drug presses drug weight y_iSequence. And Time (Pa, Pre, Med₁, Med₂..., Med_n) meet the daily schedule demand Pa (livetime) of patient.

A kind of system of intelligence computation personalization rational use of medicines time, which is characterized in that the system comprises:

It establishes drug and uses time correlation multidimensional attribute item dictionary unit；

Drug uses time correlation element information extraction unit；

Drug uses time correlation element information various dimensions processing unit；

Drug uses time priority rank setup unit；

Patient medication relevant factor information extraction unit；

Patient medication relevant factor information various dimensions processing unit；

Patient's daily schedule setup unit；

Single drug rational use of medicines time generation unit；

Patient's entirety drug rational use of medicines time schemes generation unit.

Record, analysis and the reporting unit of the practical administration time of patient.

Preferably, the system further comprises, drug uses time correlation multidimensional attribute item dictionary, is used according to drug The medicine or pharmacological properties structure of time and relevant factor and each attribute definition are established.

Preferably, the system further comprises, drug uses time correlation multidimensional attribute item dictionary, for providing drug The normal dictionary being related to drug using the every medicine or pharmacological properties of time correlation in use information and patient medication information.

Preferably, the system further comprises, drug uses time correlation multidimensional attribute item dictionary, for providing drug In use information and patient medication information with drug using time correlation every medicine or pharmacological properties separate sources different name with Normal dictionary incidence relation.

Preferably, the system further comprises, drug uses time and relevant factor database, uses the time according to drug It is established with the corresponding relationship of relevant factor information.

Preferably, the system further comprises, drug uses medicine attribute involved in time and relevant factor database Item includes at least: crowd's association attributes of patient, the special population association attributes of patient, the disease association attributes of patient, patient Medical history association attributes, the operation association attributes of patient, patient personal lifestyle history association attributes etc. wherein at least one A dimension.

Preferably, the system further comprises, drug uses pharmacological properties involved in time and relevant factor database It includes at least: medication purpose association attributes, patient of hypersensitivity's history association attributes, patient medication history association attributes, patient medication The wherein at least one dimension of administration route association attributes, patient medication related gene attribute etc..

Preferably, the system further comprises, drug uses time correlation involved in time and relevant factor database Attribute item includes at least: such as with natural rhythm and pace of moving things correlation time attribute: year, month, day, in the daytime/night, the morning/morning/noon/under Noon/night/night, season etc.；Such as with correlation time in division of day and night attribute: hour, minute；When related to individual's work and rest rule of life Between attribute such as: get up, before the meal/meal in/it is postprandial, sleep before；Such as with the state of an illness/symptom/index correlation time attribute: body temperature is more than ... When spending, when pain, when dizziness, when nervous, when nausea etc.；Such as with patient's inspection/operation/operation correlation time attribute: before inspection, After operation, when dressing；Time attribute relevant to patient's physiological period is such as: menstruation first day, menopause later six months；It is raw with patient Educate relevant time attribute such as: 24 hours after man and wife's the same branch of a family, 3 days after preparing before being pregnant March, being pregnant 24 weeks, produce；With patient Work/activity correlation time attribute is such as: the wherein at least one dimension before by bus, before high-altitude application.

Preferably, the system further comprises, drug uses time and relevant factor database, is capable of providing two or more The dictionary for needing patient's separated in time to use between drug, including but not limited to: existing because between drug interaction needs Every make the time the case where, Chinese and western drugs are used together between the case where needing interval time, drug needs containing identical/similar component Want interval time using the case where and other need the case where being spaced between drug using the time.

Preferably, the system further comprises, drug uses time and relevant factor database, can be according to each drug Using time and relevant factor information to patient safety, effective, economy, the significance level for being convenient to use drug, carry out preferential The setting of rank.

Preferably, the system further comprises, the setting of patient's daily schedule is set according to the real life rule of patient Daily schedule.

Preferably, the system further comprises, the step of patient personalized rational use of medicines time schemes generation, according to patient Daily schedule and patient used in drug rational use of medicines time scheme, generate and meet the personalized of patient real life rule and use Medicine time scheme.

Preferably, the system further comprises, the administration time that doctor, pharmacist or sufferers themselves can automatically generate in upper step On the basis of scheme, result audit and adjustment are carried out to patient personalized administration time scheme.

Preferably, the system further comprises, according to patient personalized administration time scheme and setting is reminded, system can determine When remind patient use drug.

Preferably, the system further comprises, based on mobile phone, intelligent wearable device, intelligent medicine box, intelligent medicine box, The application of the plurality of devices such as call center, wechat, short message, doctor/pharmacists ' job station is supported.

Preferably, the system further comprises, patient's rational use of medicines time scheme is in doctor, pharmacist, nursing staff, family members Data interaction between patient all can get effective, timely medication prompting to guarantee patient under various conditions.

Preferably, the system further comprises, the record of patient medication time scheme executive condition and related statements It generates, so as to doctor, pharmacist, reasonable personnel and sufferers themselves analysis, adjustment and optimization treatment plan.

Preferably, the system further comprises, drug derives from package insert, medicine using time correlation element information Allusion quotation, national formulary, treatment/medicine guide, Consensus of experts and medical institutions' medication at different levels regulation etc. wherein at least it One.

Preferably, the system further comprises, patient medication relevant information is extracted, correlation category when for extracting patient medication The actual information of property element.

Preferably, the system further comprises, the source of patient medication information is doctor formula, therapeutic scheme, uses prescription Case, case history, medical record, medicine go through, inspection result, patient's readme symptom, patient independently select medicine etc. at least one of wherein.

Preferably, the system further comprises, it is applied to C/S framework or B/S framework.

Preferably, the system further comprises, the mode of intelligent medication guide result is generated are as follows:

Patient medication relevant information is obtained, including,

Certain patient basis: age, gender, weight ...

Disease information: diagnosis, symptom, index, operation/operation, medical history ...

Medication information: prescription drug, with drug, drug allergy history ...

Other information: season, weather, pandemic ...

Certain patient (Patient, abbreviation Pa), essential information include age (age, abbreviation ag), gender (gender, abbreviation Gen), affiliated special population (special, abbreviation spe).Disease information includes diagnosis (diagnose, abbreviation dia), symptom (symptom, abbreviation sym), index (index, abbreviation ind), operation/operation (operation, abbreviation opr), medical history (history disease, abbreviation his).

Medication information includes prescription drug (prescription drug, abbreviation predrug), with drug (in use Drug, abbreviation usedrug), drug allergy history allergic history, abbreviation ale.

Other environmental information includes season (season abbreviation sesn), weather (Climate abbreviation cli), pandemic (Epidemic abbreviation Epi).

Essential information Pa (ag, gen, spe)=GetPatientBase () of patient；

Patient disease information Pa (dia, sym, ind, opr, his)=GetPatientDisease ()；

Patient medication information Pa (predrug, userug, ale)=GetPatientDrugInfo ()；

Current other information Env (sesn, cli, epi)=GetEnvironmentInfo ()；

The overall medication information Pa (info) of patient=Pa (ag, gen, spe) ∪ Pa (dia, sym, ind, opr, his) ∪ Pa(predrug,userug,ale)∪Env(sesn,cli,epi)

According to patient prescription's drug, in the administration time model for extracting related drugs from " administration time database " with drug It encloses.

The prescription drug of patient and be Med1, Med2 ..., Medn with drug, administration time range is Med_i (Time)=GetMedTime (Medi)；

Patient medication information is compareed with the applicable elements of every administration time of above-mentioned drug label, summarizes applicable item Part marks the administration time being consistent with the patient medication information, generates the rational use of medicines time model of various drugs used in the patient It encloses.

Certain Patient drug Med_iRational use of medicines time range be Med_i(Time)。

The element info of certain medication guide of this drug_k, medication information matches result with the patient are as follows:

The rational use of medicines time of this drug and the state of an illness matching result of the patient are as follows:

For some drug Med of patient Pa_i, the rational use of medicines time is Time (Pa, Med_i)=Med_i(Inst_j)*G (Pa, Med_i(Time))

Setting for the priority level of the data and each administration time that use is spaced according to the needs between various drugs Fixed, the setting of patient's daily schedule ultimately generates the reasonable administration time scheme of patient.

For the patient, for this drug Med_i, best medication time is Time (Pa, Med_i).Drug Med_iWith Med_j's Time interval is T, and priority ranking weight is y_i。

In conjunction with the clear time range that the drug division of day and night is learned, for drug Med_i, the medication frequency issued for certain specific prescription Rate f, in conjunction with the daily life daily schedule Pa (livetime) of patient, the medication Best Times range of the drug is Med_i(z₁, z₂... z_f), (z is time range, such as z₁=(7:30am, 8:00am), z₂=(12:30am, 1:00pm), z₃=(6:30pm, 7:00pm))。

Medication time of this patient about prescription Pre

Time (Pa, Pre, Med₁, Med₂..., Med_n)

=Med₁(z₁, z₂... z_f)∩Med₂(z₁, z₂... z_f)...

∩Med_n(z₁, z₂... z_f)

Wherein, Interval (Med_i, Med_j) < T (Med_i, Med_j), the time priority of drug presses drug weight y_iSequence. And Time (Pa, Pre, Med₁, Med₂..., Med_n) meet the daily schedule demand Pa (livetime) of patient.

A kind of equipment of intelligence computation personalization rational use of medicines time, which is characterized in that the equipment includes:

It establishes drug and uses time correlation multidimensional attribute item dictionary module；

Drug uses time correlation element information extraction module；

Drug uses time correlation element information various dimensions processing module；

Drug uses time priority rank setting module；

Patient medication relevant factor information extraction modules；

Patient medication relevant factor information various dimensions processing module；

Patient's daily schedule setting module；

Single drug rational use of medicines time generation module；

Patient's entirety drug rational use of medicines time schemes generation module.

Record, analysis and the reporting modules of the practical administration time of patient.

Preferably, the equipment further comprises, drug uses time correlation multidimensional attribute item dictionary, is used according to drug The medicine or pharmacological properties structure of time and relevant factor and each attribute definition are established.

Preferably, the equipment further comprises, drug uses time correlation multidimensional attribute item dictionary, for providing drug The normal dictionary being related to drug using the every medicine or pharmacological properties of time correlation in use information and patient medication information.

Preferably, the equipment further comprises, drug uses time correlation multidimensional attribute item dictionary, for providing drug In use information and patient medication information with drug using time correlation every medicine or pharmacological properties separate sources different name with Normal dictionary incidence relation.

Preferably, the equipment further comprises, drug uses time and relevant factor database, uses the time according to drug It is established with the corresponding relationship of relevant factor information.

Preferably, the equipment further comprises, drug uses medicine attribute involved in time and relevant factor database Item includes at least: crowd's association attributes of patient, the special population association attributes of patient, the disease association attributes of patient, patient Medical history association attributes, the operation association attributes of patient, patient personal lifestyle history association attributes etc. wherein at least one A dimension.

Preferably, the equipment further comprises, drug uses pharmacological properties involved in time and relevant factor database It includes at least: medication purpose association attributes, patient of hypersensitivity's history association attributes, patient medication history association attributes, patient medication The wherein at least one dimension of administration route association attributes, patient medication related gene attribute etc..

Preferably, the equipment further comprises, drug uses time correlation involved in time and relevant factor database Attribute item includes at least: such as with natural rhythm and pace of moving things correlation time attribute: year, month, day, in the daytime/night, the morning/morning/noon/under Noon/night/night, season etc.；Such as with correlation time in division of day and night attribute: hour, minute；When related to individual's work and rest rule of life Between attribute such as: get up, before the meal/meal in/it is postprandial, sleep before；Such as with the state of an illness/symptom/index correlation time attribute: body temperature is more than ... When spending, when pain, when dizziness, when nervous, when nausea etc.；Such as with patient's inspection/operation/operation correlation time attribute: before inspection, After operation, when dressing；Time attribute relevant to patient's physiological period is such as: menstruation first day, menopause later six months；It is raw with patient Educate relevant time attribute such as: 24 hours after man and wife's the same branch of a family, 3 days after preparing before being pregnant March, being pregnant 24 weeks, produce；With patient Work/activity correlation time attribute is such as: the wherein at least one dimension before by bus, before high-altitude application.

Preferably, the equipment further comprises, drug uses time and relevant factor database, is capable of providing two or more The dictionary for needing patient's separated in time to use between drug, including but not limited to: existing because between drug interaction needs Every make the time the case where, Chinese and western drugs are used together between the case where needing interval time, drug needs containing identical/similar component Want interval time using the case where and other need the case where being spaced between drug using the time.

Preferably, the equipment further comprises, drug uses time and relevant factor database, can be according to each drug Using time and relevant factor information to patient safety, effective, economy, the significance level for being convenient to use drug, carry out preferential The setting of rank.

Preferably, the equipment further comprises, the setting of patient's daily schedule is set according to the real life rule of patient Daily schedule.

Preferably, the equipment further comprises, the step of patient personalized rational use of medicines time schemes generation, according to patient Daily schedule and patient used in drug rational use of medicines time scheme, generate and meet the personalized of patient real life rule and use Medicine time scheme.

Preferably, the equipment further comprises, the administration time that doctor, pharmacist or sufferers themselves can automatically generate in upper step On the basis of scheme, result audit and adjustment are carried out to patient personalized administration time scheme.

Preferably, the equipment further comprises, according to patient personalized administration time scheme and setting is reminded, system can determine When remind patient use drug.

Preferably, the equipment further comprises, based on mobile phone, intelligent wearable device, intelligent medicine box, intelligent medicine box, The application of the plurality of devices such as call center, wechat, short message, doctor/pharmacists ' job station is supported.

Preferably, the equipment further comprises, patient's rational use of medicines time scheme is in doctor, pharmacist, nursing staff, family members Data interaction between patient all can get effective, timely medication prompting to guarantee patient under various conditions.

Preferably, the equipment further comprises, the record of patient medication time scheme executive condition and related statements It generates, so as to doctor, pharmacist, reasonable personnel and sufferers themselves analysis, adjustment and optimization treatment plan.

Preferably, the equipment further comprises, drug derives from package insert, medicine using time correlation element information Allusion quotation, national formulary, treatment/medicine guide, Consensus of experts and medical institutions' medication at different levels regulation etc. wherein at least it One.

Preferably, the equipment further comprises, patient medication relevant information is extracted, correlation category when for extracting patient medication The actual information of property element.

Preferably, the equipment further comprises, the source of patient medication information is doctor formula, therapeutic scheme, uses prescription Case, case history, medical record, medicine go through, inspection result, patient's readme symptom, patient independently select medicine etc. at least one of wherein.

Preferably, the equipment further applies C/S framework or B/S framework.

Preferably, the equipment further comprises, the mode of intelligent medication guide result is generated are as follows:

Patient medication relevant information is obtained, including,

Certain patient basis: age, gender, weight ...

Disease information: diagnosis, symptom, index, operation/operation, medical history ...

Medication information: prescription drug, with drug, drug allergy history ...

Other information: season, weather, pandemic ...

Certain patient (Patient, abbreviation Pa), essential information include age (age, abbreviation ag), gender (gender, abbreviation Gen), affiliated special population (special, abbreviation spe).Disease information includes diagnosis (diagnose, abbreviation dia), symptom (symptom, abbreviation sym), index (index, abbreviation ind), operation/operation (operation, abbreviation opr), medical history (history disease, abbreviation his).

Medication information includes prescription drug (prescription drug, abbreviation predrug), with drug (in use Drug, abbreviation usedrug), drug allergy history allergic history, abbreviation ale.

Other environmental information includes season (season abbreviation sesn), weather (Climate abbreviation cli), pandemic (Epidemic abbreviation Epi).

Essential information Pa (ag, gen, spe)=GetPatientBase () of patient；

Patient disease information Pa (dia, sym, ind, opr, his)=GetPatientDisease ()；

Patient medication information Pa (predrug, userug, ale)=GetPatientDrugInfo ()；

Current other information Env (sesn, cli, epi)=GetEnvironmentInfo ()；

The overall medication information Pa (info) of patient=Pa (ag, gen, spe) ∪ Pa (dia, sym, ind, opr, his) ∪ Pa(predrug,userug,ale)∪Env(sesn,cli,epi)

According to patient prescription's drug, in the administration time model for extracting related drugs from " administration time database " with drug It encloses.

The prescription drug of patient and be Med1, Med2 ..., Medn with drug, administration time range is Med_i (Time)=GetMedTime (Medi)；

Patient medication information is compareed with the applicable elements of every administration time of above-mentioned drug label, summarizes applicable item Part marks the administration time being consistent with the patient medication information, generates the rational use of medicines time model of various drugs used in the patient It encloses.

Certain Patient drug Med_iRational use of medicines time range be Med_i(Time)。

The element info of certain medication guide of this drug_k, medication information matches result with the patient are as follows:

The rational use of medicines time of this drug and the state of an illness matching result of the patient are as follows:

For some drug Med of patient Pa_i, the rational use of medicines time is Time (Pa, Med_i)=Med_i(Inst_j)*G (Pa, Med_i(Time))

Setting for the priority level of the data and each administration time that use is spaced according to the needs between various drugs Fixed, the setting of patient's daily schedule ultimately generates the reasonable administration time scheme of patient.

For the patient, for this drug Med_i, best medication time is Time (Pa, Med_i).Drug Med_iWith Med_j's Time interval is T, and priority ranking weight is y_i。

In conjunction with the clear time range that the drug division of day and night is learned, for drug Med_i, the medication frequency issued for certain specific prescription Rate f, in conjunction with the daily life daily schedule Pa (livetime) of patient, the medication Best Times range of the drug is Med_i(z₁, z₂... z_f), (z is time range, such as z₁=(7:30am, 8:00am), z₂=(12:30am, 1:00pm), z₃=(6:30pm, 7:00pm))。

Medication time of this patient about prescription Pre

Time (Pa, Pre, Med₁, Med₂..., Med_n)

=Med₁(z₁, z₂... z_f)∩Med₂(z₁, z₂... z_f)...

∩Med_n(z₁, z₂... z_f)

Wherein, Interval (Med_i, Med_j) < T (Med_i, Med_j), the time priority of drug presses drug weight y_iSequence. And Time (Pa, Pre, Med₁, Med₂..., Med_n) meet the daily schedule demand Pa (livetime) of patient.

Detailed description of the invention

Fig. 1 shows the system according to the present invention structural schematic diagram；

Fig. 2 shows the method flow schematic diagrams of intelligence computation personalization rational use of medicines time according to the present invention；

Fig. 3 shows the illustrative view of functional configuration of intelligence computation personalization rational use of medicines time according to the present invention；

Specific embodiment

In order to make the objectives, technical solutions, and advantages of the present invention clearer, with reference to the accompanying drawings and embodiments, right The present invention is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, and It is not used in the restriction present invention.

Fig. 1 shows system construction drawing of the invention.Wherein, work station passes through public network or medical institutions, retail pharmacies Intranet is connected to server.Work station includes doctor's work station, pharmacists ' job station, salesman's work station, patient's self-aided terminal etc..Work Making station can be wherein at least one of PC terminal, mobile terminal, wearable device etc..The network architecture of work station and server It can be C/S framework and be also possible to B/S framework.

Fig. 2 is one embodiment of the present of invention, a kind of workflow of intelligence computation personalization rational use of medicines time method Schematic diagram.

Step 101, drug is established using time correlation multidimensional attribute item dictionary, for providing multidimensional attribute item word Allusion quotation.

Drug uses time correlation multidimensional attribute item dictionary, uses time and the medicine or medicine of relevant factor according to drug It learns attribute structure and each attribute definition is established.The time is used with drug for providing in drug use information and patient medication information The normal dictionary that relevant items medicine or pharmacological properties are related to.For provide in drug use information and patient medication information with Drug using time correlation every medicine or pharmacological properties separate sources different name and normal dictionary incidence relation.

Step 102, drug is extracted using time correlation element information, is believed for extracting drug using the relevant factor of time Breath.

Drug is referred to using time correlation element information from package insert, pharmacopeia, national formulary, treatment/medication At least one of them that south, Consensus of experts and medical institutions' medication at different levels provide etc..

Step 103, drug is handled using time correlation element information various dimensions, according to multidimensional attribute item dictionary unit pair Drug is handled using time correlation element information, is generated drug and is used time and relevant factor database.

Drug uses time and relevant factor database, and the corresponding relationship of time and relevant factor information are used according to drug It establishes.

Drug is included at least using medicine attribute item involved in time and relevant factor database: the crowd of patient is related Attribute, the special population association attributes of patient, the disease association attributes of patient, the medical history association attributes of patient, patient Operate association attributes, patient personal lifestyle history association attributes etc. wherein at least one dimension.

Drug is included at least using pharmacological properties item involved in time and relevant factor database: medication purpose correlation category Property, patient of hypersensitivity's history association attributes, patient medication history association attributes, the administration route association attributes of patient medication, patient medication The wherein at least one dimension of related gene attribute etc..

Drug is included at least using time-related attributes item involved in time and relevant factor database: with the natural rhythm and pace of moving things Correlation time attribute is such as: year, month, day, in the daytime/night, the morning/morning/noon/afternoon/night/night, season；With the division of day and night Correlation time attribute is such as: hour, minute；Such as with individual's work and rest rule of life correlation time attribute: getting up, before the meal and/in meal/eat Afterwards, before sleeping etc.；Such as with the state of an illness/symptom/index correlation time attribute: body temperature is more than ... when spending, when pain, when dizziness, when nervous, When nauseous etc.；Such as with patient's inspection/operation/operation correlation time attribute: before inspection, after operation, when dressing；With patient's physiology week Phase relevant time attribute is such as: menstruation first day, menopause later six months；Time attribute relevant to patient's fertility is such as: Fu Qitong 24 hours behind room, 3 days etc. after preparing before being pregnant March, being pregnant 24 weeks, produce；Such as with patient work/activity correlation time attribute: Wherein at least one dimension before by bus, before high-altitude application etc..

Drug uses time and relevant factor database, is capable of providing between two or more drugs and needs patient interval certain The dictionary that time uses, including but not limited to: there is the case where needing interval time to make because of drug interaction, Chinese and western drugs one Rise contain between use the case where needing interval time, drug the case where identical/similar component needs interval time to use and Other need the case where being spaced between drug using the time.

Drug uses time and relevant factor database, can use time and relevant factor information pair according to each drug Patient safety, effective, economy, the significance level for being convenient to use drug, carry out the setting of priority level.

Step 104, drug is set using time priority rank, is using different pharmaceutical according to different patients, various disease When drug use time importance information relevant to disease treatment, adverse drug reaction, set each drug use the time and The priority level of relevant factor.

Step 105, patient medication relevant factor information extraction, for extracting patient medication relevant factor information.Patient uses Medicine relevant information is extracted, the actual information of association attributes element when for extracting patient medication.The source of patient medication information is Doctor formula, therapeutic scheme, therapeutic regimen, case history, medical record, medicine go through, inspection result, patient's readme symptom, patient independently select medicine Deng at least one of wherein.

Step 106, patient medication relevant factor information various dimensions are handled, and use time correlation multidimensional attribute according to drug Item dictionary unit handles patient medication relevant factor information.

Step 107, patient's daily schedule sets, and sets the daily schedule according to the real life rule of patient.

Step 108, the single drug rational use of medicines time generates, when being used according to patient medication relevant factor information and drug Between and relevant factor database, generate single rational application of medicine time range.

Step 109, patient's entirety drug rational use of medicines time schemes generation, the kind of drug is integrally used according to patient, The single rational application of medicine time range of each drug, need to be spaced in drug the drug used and need to be spaced use when Between, each drug generates whole rational use of medicines time scheme using time and the priority level of relevant factor.

In patient's entirety drug rational use of medicines time schemes generation, the mode of matching result is generated are as follows:

Patient medication relevant information is obtained, including,

Certain patient basis: age, gender, weight ...

Disease information: diagnosis, symptom, index, operation/operation, medical history ...

Medication information: prescription drug, with drug, drug allergy history ...

Other information: season, weather, pandemic ...

Certain patient (Patient, abbreviation Pa), essential information include age (age, abbreviation ag), gender (gender, abbreviation Gen), affiliated special population (special, abbreviation spe).Disease information includes diagnosis (diagnose, abbreviation dia), symptom (symptom, abbreviation sym), index (index, abbreviation ind), operation/operation (operation, abbreviation opr), medical history (history disease, abbreviation his).

Medication information includes prescription drug (prescription drug, abbreviation predrug), with drug (in use Drug, abbreviation usedrug), drug allergy history allergic history, abbreviation ale.

Other environmental information includes season (season abbreviation sesn), weather (Climate abbreviation cli), pandemic (Epidemic abbreviation Epi).

Essential information Pa (ag, gen, spe)=GetPatientBase () of patient；

Patient disease information Pa (dia, sym, ind, opr, his)=GetPatientDisease ()；

Patient medication information Pa (predrug, userug, ale)=GetPatientDrugInfo ()；

Current other information Env (sesn, cli, epi)=GetEnvironmentInfo ()；

The overall medication information Pa (info) of patient=Pa (ag, gen, spe) ∪ Pa (dia, sym, ind, opr, his) ∪ Pa(predrug,userug,ale)∪Env(sesn,cli,epi)

According to patient prescription's drug, in the administration time model for extracting related drugs from " administration time database " with drug It encloses.

The prescription drug of patient and be Med1, Med2 ..., Medn with drug, administration time range is Med_i (Time)=GetMedTime (Medi)；

Patient medication information is compareed with the applicable elements of every administration time of above-mentioned drug label, summarizes applicable item Part marks the administration time being consistent with the patient medication information, generates the rational use of medicines time model of various drugs used in the patient It encloses.

Certain Patient drug Med_iRational use of medicines time range be Med_i(Time)。

The element info of certain medication guide of this drug_k, medication information matches result with the patient are as follows:

The rational use of medicines time of this drug and the state of an illness matching result of the patient are as follows:

For some drug Med of patient Pa_i, the rational use of medicines time is Time (Pa, Med_i)=Med_i(Inst_j)*G (Pa, Med_i(Time))

Setting for the priority level of the data and each administration time that use is spaced according to the needs between various drugs Fixed, the setting of patient's daily schedule ultimately generates the reasonable administration time scheme of patient.

For the patient, for this drug Med_i, best medication time is Time (Pa, Med_i).Drug Med_iWith Med_j's Time interval is T, and priority ranking weight is y_i。

In conjunction with the clear time range that the drug division of day and night is learned, for drug Med_i, the medication frequency issued for certain specific prescription Rate f, in conjunction with the daily life daily schedule Pa (livetime) of patient, the medication Best Times range of the drug is Med_i(z₁, z₂... z_f), (z is time range, such as z₁=(7:30am, 8:00am), z₂=(12:30am, 1:00pm), z₃=(6:30pm, 7:00pm))。

Medication time of this patient about prescription Pre

Time (Pa, Pre, Med₁, Med₂..., Med_n)

=Med₁(z₁, z₂... z_f)∩Med₂(z₁, z₂... z_f)...

∩Med_n(z₁, z₂... z_f)

Wherein, Interval (Med_i, Med_j) < T (Med_i, Med_j), the time priority of drug presses drug weight y_iSequence. And Time (Pa, Pre, Med₁, Med₂..., Med_n) meet the daily schedule demand Pa (livetime) of patient.

The step of this method further comprises, the setting of patient's daily schedule sets according to the real life rule of patient Daily schedule.

The step of this method further comprises, patient personalized rational use of medicines time schemes generation, according to the work and rest of patient The rational use of medicines time scheme of time and drug used in patient generate the personalized medicine time for meeting patient's real life rule Scheme.

This method further comprises according to patient personalized administration time scheme and reminding setting, can timed reminding patient Use drug.

This method further comprises that doctor, pharmacist or sufferers themselves can be in the administration time schemes that upper step automatically generates On the basis of, result audit and adjustment are carried out to patient personalized administration time scheme.

This method further comprises, based in mobile phone, intelligent wearable device, intelligent medicine box, intelligent medicine box, calling The application of the plurality of devices such as the heart, wechat, short message, doctor/pharmacists ' job station is supported.

This method further comprises that patient's rational use of medicines time scheme is in doctor, pharmacist, nursing staff, family members and patient Between data interaction, with guarantee patient under various conditions all can get effectively, timely medication remind.

This method further comprises the generation of the record and related statements of patient medication time scheme executive condition, with Just doctor, pharmacist, reasonable personnel and sufferers themselves' analysis, adjustment and optimization treatment plan.

This method is applied to C/S framework or B/S framework.

Fig. 3 is one embodiment of the present of invention, a kind of functional structure of intelligence computation personalization rational use of medicines time system Schematic diagram, the system include establishing drug using time correlation multidimensional attribute item dictionary unit 201, and drug uses time correlation Element information extraction unit 202, drug use time correlation element information various dimensions processing unit 203, and drug is excellent using the time First grade setting unit 204, patient medication relevant factor information extraction unit 205, patient medication relevant factor information various dimensions Processing unit 206, patient's daily schedule setup unit 207, single drug rational use of medicines time generation unit 208, patient are whole Drug rational use of medicines time schemes generation unit 209.

Drug is established using time correlation multidimensional attribute item dictionary unit 201, for providing multidimensional attribute item dictionary.

Drug uses time correlation multidimensional attribute item dictionary, uses time and the medicine or medicine of relevant factor according to drug It learns attribute structure and each attribute definition is established.The time is used with drug for providing in drug use information and patient medication information The normal dictionary that relevant items medicine or pharmacological properties are related to.For provide in drug use information and patient medication information with Drug using time correlation every medicine or pharmacological properties separate sources different name and normal dictionary incidence relation.

Drug uses time correlation element information extraction unit 202, is believed for extracting drug using the relevant factor of time Breath.

Drug is referred to using time correlation element information from package insert, pharmacopeia, national formulary, treatment/medication At least one of them that south, Consensus of experts and medical institutions' medication at different levels provide etc..

Drug uses time correlation element information various dimensions processing unit 203, according to multidimensional attribute item dictionary unit pair Drug is handled using time correlation element information, is generated drug and is used time and relevant factor database.

Drug uses time and relevant factor database, and the corresponding relationship of time and relevant factor information are used according to drug It establishes.

Drug is included at least using medicine attribute item involved in time and relevant factor database: the crowd of patient is related Attribute, the special population association attributes of patient, the disease association attributes of patient, the medical history association attributes of patient, patient Operate association attributes, patient personal lifestyle history association attributes etc. wherein at least one dimension.

Drug is included at least using pharmacological properties item involved in time and relevant factor database: medication purpose correlation category Property, patient of hypersensitivity's history association attributes, patient medication history association attributes, the administration route association attributes of patient medication, patient medication The wherein at least one dimension of related gene attribute etc..

Drug is included at least using time-related attributes item involved in time and relevant factor database: with the natural rhythm and pace of moving things Correlation time attribute is such as: year, month, day, in the daytime/night, the morning/morning/noon/afternoon/night/night, season；With the division of day and night Correlation time attribute is such as: hour, minute；Such as with individual's work and rest rule of life correlation time attribute: getting up, before the meal and/in meal/eat Afterwards, before sleeping etc.；Such as with the state of an illness/symptom/index correlation time attribute: body temperature is more than ... when spending, when pain, when dizziness, when nervous, When nauseous etc.；Such as with patient's inspection/operation/operation correlation time attribute: before inspection, after operation, when dressing；With patient's physiology week Phase relevant time attribute is such as: menstruation first day, menopause later six months；Time attribute relevant to patient's fertility is such as: Fu Qitong 24 hours behind room, 3 days etc. after preparing before being pregnant March, being pregnant 24 weeks, produce；Such as with patient work/activity correlation time attribute: Wherein at least one dimension before by bus, before high-altitude application etc..

Drug uses time and relevant factor database, is capable of providing between two or more drugs and needs patient interval certain The dictionary that time uses, including but not limited to: there is the case where needing interval time to make because of drug interaction, Chinese and western drugs one Rise contain between use the case where needing interval time, drug the case where identical/similar component needs interval time to use and Other need the case where being spaced between drug using the time.

Drug uses time and relevant factor database, can use time and relevant factor information pair according to each drug Patient safety, effective, economy, the significance level for being convenient to use drug, carry out the setting of priority level.

Drug uses time priority rank setup unit 204, according to different patients, various disease when using different pharmaceutical Drug uses time importance information relevant to disease treatment, adverse drug reaction, sets each drug and uses time and phase Close the priority level of element.

Patient medication relevant factor information extraction unit 205, for extracting patient medication relevant factor information.Patient medication Relevant information extraction unit, the actual information of association attributes element when for extracting patient medication.The source of patient medication information It is gone through for doctor formula, therapeutic scheme, therapeutic regimen, case history, medical record, medicine, inspection result, patient's readme symptom, patient independently select Medicine etc. is at least one of wherein.

Patient medication relevant factor information various dimensions processing unit 206 uses time correlation multidimensional attribute according to drug Item dictionary unit handles patient medication relevant factor information.

Patient's daily schedule setup unit 207 sets the daily schedule according to the real life rule of patient.

Single drug rational use of medicines time generation unit 208, when being used according to patient medication relevant factor information and drug Between and relevant factor database, generate single rational application of medicine time range.

Patient's entirety drug rational use of medicines time schemes generation unit 209, the kind of drug is integrally used according to patient, respectively The single rational application of medicine time range of drug, need to be spaced in drug the drug used and need to be spaced use when Between, each drug generates whole rational use of medicines time scheme using time and the priority level of relevant factor.

In patient's entirety drug rational use of medicines time schemes generation unit, the mode of matching result is generated are as follows:

Patient medication relevant information is obtained, including,

Certain patient basis: age, gender, weight ...

Disease information: diagnosis, symptom, index, operation/operation, medical history ...

Medication information: prescription drug, with drug, drug allergy history ...

Other information: season, weather, pandemic ...

Certain patient (Patient, abbreviation Pa), essential information include age (age, abbreviation ag), gender (gender, abbreviation Gen), affiliated special population (special, abbreviation spe).Disease information includes diagnosis (diagnose, abbreviation dia), symptom (symptom, abbreviation sym), index (index, abbreviation ind), operation/operation (operation, abbreviation opr), medical history (history disease, abbreviation his).

Medication information includes prescription drug (prescription drug, abbreviation predrug), with drug (in use Drug, abbreviation usedrug), drug allergy history allergic history, abbreviation ale.

Other environmental information includes season (season abbreviation sesn), weather (Climate abbreviation cli), pandemic (Epidemic abbreviation Epi).

Essential information Pa (ag, gen, spe)=GetPatientBase () of patient；

Patient disease information Pa (dia, sym, ind, opr, his)=GetPatientDisease ()；

Patient medication information Pa (predrug, userug, ale)=GetPatientDrugInfo ()；

Current other information Env (sesn, cli, epi)=GetEnvironmentInfo ()；

The overall medication information Pa (info) of patient=Pa (ag, gen, spe) ∪ Pa (dia, sym, ind, opr, his) ∪ Pa(predrug,userug,ale)∪Env(sesn,cli,epi)

According to patient prescription's drug, in the administration time model for extracting related drugs from " administration time database " with drug It encloses.

The prescription drug of patient and be Med1, Med2 ..., Medn with drug, administration time range is Med_i (Time)=GetMedTime (Medi)；

Patient medication information is compareed with the applicable elements of every administration time of above-mentioned drug label, summarizes applicable item Part marks the administration time being consistent with the patient medication information, generates the rational use of medicines time model of various drugs used in the patient It encloses.

Certain Patient drug Med_iRational use of medicines time range be Med_i(Time)。

The element info of certain medication guide of this drug_k, medication information matches result with the patient are as follows:

The rational use of medicines time of this drug and the state of an illness matching result of the patient are as follows:

For some drug Med of patient Pa_i, the rational use of medicines time is Time (Pa, Med_i)=Med_i(Inst_j)*G (Pa, Med_i(Time))

Setting for the priority level of the data and each administration time that use is spaced according to the needs between various drugs Fixed, the setting of patient's daily schedule ultimately generates the reasonable administration time scheme of patient.

For the patient, for this drug Med_i, best medication time is Time (Pa, Med_i).Drug Med_iWith Med_j's Time interval is T, and priority ranking weight is y_i。

In conjunction with the clear time range that the drug division of day and night is learned, for drug Med_i, the medication frequency issued for certain specific prescription Rate f, in conjunction with the daily life daily schedule Pa (livetime) of patient, the medication Best Times range of the drug is Med_i(z₁, z₂... z_f), (z is time range, such as z₁=(7:30am, 8:00am), z₂=(12:30am, 1:00pm), z₃=(6:30pm, 7:00pm))。

Medication time of this patient about prescription Pre

Time (Pa, Pre, Med₁, Med₂..., Med_n)

=Med₁(z₁, z₂... z_f)∩Med₂(z₁, z₂... z_f)...

∩Med_n(z₁, z₂... z_f)

Wherein, Interval (Med_i, Med_j) < T (Med_i, Med_j), the time priority of drug presses drug weight y_iSequence. And Time (Pa, Pre, Med₁, Med₂..., Med_n) meet the daily schedule demand Pa (livetime) of patient.

The system further comprises the setup unit of patient's daily schedule, is set and is made according to the real life rule of patient Cease the time.

The system further comprises patient personalized rational use of medicines time schemes generation unit, when according to the work and rest of patient Between rational use of medicines time scheme with drug used in patient, generate the personalized medicine time side for meeting patient's real life rule Case.

The system further comprises according to patient personalized administration time scheme and reminding setting, system can timed reminding Patient uses drug.

The system further comprises that doctor, pharmacist or sufferers themselves can be in the administration time schemes that upper step automatically generates On the basis of, result audit and adjustment are carried out to patient personalized administration time scheme.

The system further comprises, based in mobile phone, intelligent wearable device, intelligent medicine box, intelligent medicine box, calling The application of the plurality of devices such as the heart, wechat, short message, doctor/pharmacists ' job station is supported.

The system further comprises that patient's rational use of medicines time scheme is in doctor, pharmacist, nursing staff, family members and patient Between data interaction, with guarantee patient under various conditions all can get effectively, timely medication remind.

The system further comprises the generation of the record and related statements of patient medication time scheme executive condition, with Just doctor, pharmacist, reasonable personnel and sufferers themselves' analysis, adjustment and optimization treatment plan.

The system uses C/S framework or B/S framework.

The present invention further provides a kind of intelligence computation personalization rational use of medicines time device, which includes establishing drug Using time correlation multidimensional attribute item dictionary module, drug uses time correlation element information extraction module, when drug uses Between relevant factor information various dimensions processing module, drug use time priority rank setting module, patient medication relevant factor letter Cease extraction module, patient medication relevant factor information various dimensions processing module, patient's daily schedule setting module, the conjunction of single drug Manage administration time generation module, patient's entirety drug rational use of medicines time schemes generation module.

Drug is established using time correlation multidimensional attribute item dictionary module, for providing multidimensional attribute item dictionary.

Drug uses time correlation multidimensional attribute item dictionary, uses time and the medicine or medicine of relevant factor according to drug It learns attribute structure and each attribute definition is established.The time is used with drug for providing in drug use information and patient medication information The normal dictionary that relevant items medicine or pharmacological properties are related to.For provide in drug use information and patient medication information with Drug using time correlation every medicine or pharmacological properties separate sources different name and normal dictionary incidence relation.

Drug uses time correlation element information extraction module, and the relevant factor information of time is used for extracting drug.

Drug is referred to using time correlation element information from package insert, pharmacopeia, national formulary, treatment/medication At least one of them that south, Consensus of experts and medical institutions' medication at different levels provide etc..

Drug uses time correlation element information various dimensions processing module, according to multidimensional attribute item dictionary unit to drug It is handled using time correlation element information, generates drug and use time and relevant factor database.

Drug uses time and relevant factor database, and the corresponding relationship of time and relevant factor information are used according to drug It establishes.

Drug is included at least using medicine attribute item involved in time and relevant factor database: the crowd of patient is related Attribute, the special population association attributes of patient, the disease association attributes of patient, the medical history association attributes of patient, patient Operate association attributes, patient personal lifestyle history association attributes etc. wherein at least one dimension.

Drug is included at least using pharmacological properties item involved in time and relevant factor database: medication purpose correlation category Property, patient of hypersensitivity's history association attributes, patient medication history association attributes, the administration route association attributes of patient medication, patient medication The wherein at least one dimension of related gene attribute etc..

Drug is included at least using time-related attributes item involved in time and relevant factor database: with the natural rhythm and pace of moving things Correlation time attribute is such as: year, month, day, in the daytime/night, the morning/morning/noon/afternoon/night/night, season；With the division of day and night Correlation time attribute is such as: hour, minute；Such as with individual's work and rest rule of life correlation time attribute: getting up, before the meal and/in meal/eat Afterwards, before sleeping etc.；Such as with the state of an illness/symptom/index correlation time attribute: body temperature is more than ... when spending, when pain, when dizziness, when nervous, When nauseous etc.；Such as with patient's inspection/operation/operation correlation time attribute: before inspection, after operation, when dressing；With patient's physiology week Phase relevant time attribute is such as: menstruation first day, menopause later six months；Time attribute relevant to patient's fertility is such as: Fu Qitong 24 hours behind room, 3 days etc. after preparing before being pregnant March, being pregnant 24 weeks, produce；Such as with patient work/activity correlation time attribute: Wherein at least one dimension before by bus, before high-altitude application etc..

Drug uses time and relevant factor database, is capable of providing between two or more drugs and needs patient interval certain The dictionary that time uses, including but not limited to: there is the case where needing interval time to make because of drug interaction, Chinese and western drugs one Rise contain between use the case where needing interval time, drug the case where identical/similar component needs interval time to use and Other need the case where being spaced between drug using the time.

Drug uses time and relevant factor database, can use time and relevant factor information pair according to each drug Patient safety, effective, economy, the significance level for being convenient to use drug, carry out the setting of priority level.

Drug uses time priority rank setting module, according to different patients, various disease when using different pharmaceutical medicine Object uses time importance information relevant to disease treatment, adverse drug reaction, sets each drug and uses time and correlation The priority level of element.

Patient medication relevant factor information extraction modules, for extracting patient medication relevant factor information.Patient medication phase Close information extraction modules, the actual information of association attributes element when for extracting patient medication.The source of patient medication information is Doctor formula, therapeutic scheme, therapeutic regimen, case history, medical record, medicine go through, inspection result, patient's readme symptom, patient independently select medicine Deng at least one of wherein.

Patient medication relevant factor information various dimensions processing module uses time correlation multidimensional attribute item word according to drug Allusion quotation unit handles patient medication relevant factor information.

Patient's daily schedule setting module sets the daily schedule according to the real life rule of patient.

Single drug rational use of medicines time generation module, according to patient medication relevant factor information and drug using the time and Relevant factor database generates single rational application of medicine time range.

Patient's entirety drug rational use of medicines time schemes generation module, the kind of drug, each medicine are integrally used according to patient The single rational application of medicine time range of product needs to be spaced the drug used in drug and needs to be spaced the time used, Each drug generates whole rational use of medicines time scheme using time and the priority level of relevant factor.

In patient's entirety drug rational use of medicines time schemes generation module, the mode of matching result is generated are as follows:

Patient medication relevant information is obtained, including,

Certain patient basis: age, gender, weight ...

Disease information: diagnosis, symptom, index, operation/operation, medical history ...

Medication information: prescription drug, with drug, drug allergy history ...

Other information: season, weather, pandemic ...

Certain patient (Patient, abbreviation Pa), essential information include age (age, abbreviation ag), gender (gender, abbreviation Gen), affiliated special population (special, abbreviation spe).Disease information includes diagnosis (diagnose, abbreviation dia), symptom (symptom, abbreviation sym), index (index, abbreviation ind), operation/operation (operation, abbreviation opr), medical history (history disease, abbreviation his).

Medication information includes prescription drug (prescription drug, abbreviation predrug), with drug (in use Drug, abbreviation usedrug), drug allergy history allergic history, abbreviation ale.

Other environmental information includes season (season abbreviation sesn), weather (Climate abbreviation cli), pandemic (Epidemic abbreviation Epi).

Essential information Pa (ag, gen, sap)=GetPatientBase () of patient；

Patient disease information Pa (dia, sym, ind, opr, his)=GetPatientDisease ()；

Patient medication information Pa (predrug, userug, ale)=GetPatientDrugInfo ()；

Current other information Env (sesn, cli, epi)=GetEnvironmentInfo ()；

The overall medication information Pa (info) of patient=Pa (ag, gen, spa) ∪ Pa (dia, sym, ind, opr, his) ∪ Pa(predrug,userug,ale)∪Env(sesn,cli,epi)

According to patient prescription's drug, in the administration time model for extracting related drugs from " administration time database " with drug It encloses.

The prescription drug of patient and be Med1, Med2 ..., Medn with drug, administration time range is Med_i (Time)=GetMedTime (Medi)；

Patient medication information is compareed with the applicable elements of every administration time of above-mentioned drug label, summarizes applicable item Part marks the administration time being consistent with the patient medication information, generates the rational use of medicines time model of various drugs used in the patient It encloses.

Certain Patient drug Med_iRational use of medicines time range be Med_i(Time)。

The element info of certain medication guide of this drug_k, medication information matches result with the patient are as follows:

The rational use of medicines time of this drug and the state of an illness matching result of the patient are as follows:

For some drug Med of patient Pa_i, the rational use of medicines time is Time (Pa, Med_i)=Med_i(Inst_j)*G (Pa, Med_i(Time))

Setting for the priority level of the data and each administration time that use is spaced according to the needs between various drugs Fixed, the setting of patient's daily schedule ultimately generates the reasonable administration time scheme of patient.

For the patient, for this drug Med_i, best medication time is Time (Pa, Med_i).Drug Med_iWith Med_j's Time interval is T, and priority ranking weight is y_i。

In conjunction with the clear time range that the drug division of day and night is learned, for drug Med_i, the medication frequency issued for certain specific prescription Rate f, in conjunction with the daily life daily schedule Pa (livetime) of patient, the medication Best Times range of the drug is Med_i(z₁, z₂... z_f), (z is time range, such as z₁=(7:30am, 8:00am), z₂=(12:30am, 1:00pm), z₃=(6:30pm, 7:00pm))。

Medication time of this patient about prescription Pre

Time (Pa, Pre, Med₁, Med₂..., Med_n)

=Med₁(z₁, z₂... z_f)∩Med₂(z₁, z₂... z_f)...

∩Med_n(z₁, z₂... z_f)

Wherein, Interval (Med_i, Med_j) < T (Med_i, Med_j), the time priority of drug presses drug weight y_iSequence. And Time (Pa, Pre, Med₁, Med₂..., Med_n) meet the daily schedule demand Pa (livetime) of patient.

The equipment further comprises the setting module of patient's daily schedule, is set and is made according to the real life rule of patient Cease the time.

The equipment further comprises patient personalized rational use of medicines time schemes generation module, when according to the work and rest of patient Between rational use of medicines time scheme with drug used in patient, generate the personalized medicine time side for meeting patient's real life rule Case.

The equipment may further be arranged according to patient personalized administration time scheme and prompting, and meeting timed reminding patient makes Use drug.

The equipment further comprises that doctor, pharmacist or sufferers themselves can be in the administration time schemes that upper step automatically generates On the basis of, result audit and adjustment are carried out to patient personalized administration time scheme.

The equipment further comprises, based in mobile phone, intelligent wearable device, intelligent medicine box, intelligent medicine box, calling The application of the plurality of devices such as the heart, wechat, short message, doctor/pharmacists ' job station is supported.

The equipment further comprises that patient's rational use of medicines time scheme is in doctor, pharmacist, nursing staff, family members and patient Between data interaction, with guarantee patient under various conditions all can get effectively, timely medication remind.

The equipment further comprises the generation of the record and related statements of patient medication time scheme executive condition, with Just doctor, pharmacist, reasonable personnel and sufferers themselves' analysis, adjustment and optimization treatment plan.

System of the equipment for C/S framework or B/S framework.

Specific embodiments of the present invention are described above.It is to be appreciated that the invention is not limited to above-mentioned Particular implementation, those skilled in the art can make various deformations or amendments within the scope of the claims, this not shadow Ring substantive content of the invention.

Claims (33)

1. a kind of method of intelligence computation personalization rational use of medicines time, which is characterized in that the described method includes:

When establishing drug use using the medicine or pharmacological properties structure and each attribute definition of time and relevant factor according to drug Between related multidimensional attribute item dictionary；From package insert, pharmacopeia, national formulary, treatment/medicine guide, Consensus of experts, with And it in medical institutions' medication regulations at different levels, extracts drug and uses time and relevant factor information；

Drug is handled using time and relevant factor information various dimensions；

Time pass corresponding with relevant factor information is used using every kind of drug in time and relevant factor information according to drug System establishes drug using time and relevant factor database, which includes time-related attributes, medicine association attributes and medicine Association attributes are learned, and are capable of providing the dictionary that patient's separated in time is needed to use between two or more drugs；

The database can according to each group drug using time and relevant factor information to patient safety, effectively, it is economical, convenient Using the significance level of drug, priority level setting is carried out using the time to each group drug；

Patient medication relevant factor information extraction；

The processing of patient medication relevant factor information various dimensions；

Patient's daily schedule sets；

According to patient medication relevant factor information and the daily schedule of patient, time and relevant factor database are used from drug Middle inquiry, the reasonable employment time for extracting each drug used in the patient being consistent with patient's relevant medical, pharmacological properties, To realize that the single drug rational use of medicines time generates；

Integrally use the kind of drug according to patient, the single drug reasonable employment time range of each drug, between needing in drug Every the drug used and need to be spaced the time used, each drug is generated and suffered from using time and the priority level of relevant factor Person's entirety drug rational use of medicines time scheme；

Record, analysis and the report of the practical administration time of patient.

2. the method for intelligence computation personalization rational use of medicines time according to claim 1 a kind of, which is characterized in that the party Method further comprises that drug uses time correlation multidimensional attribute item dictionary, for providing drug use information and patient medication The normal dictionary being related to drug using the every medicine or pharmacological properties of time correlation in information.

3. the method for intelligence computation personalization rational use of medicines time according to claim 1 a kind of, which is characterized in that the party Method further comprises that drug uses time correlation multidimensional attribute item dictionary, for providing drug use information and patient medication The every medicine or pharmacological properties separate sources different name and normal dictionary incidence relation of time correlation are used with drug in information.

4. the method for intelligence computation personalization rational use of medicines time according to claim 1 to 3 a kind of, special Sign is that this method further comprises that drug uses medicine association attributes item packet involved in time and relevant factor database Include: crowd's association attributes of patient, the special population association attributes of patient, the disease association attributes of patient, the past of patient are sick History association attributes, patient operation association attributes, patient personal lifestyle history association attributes wherein at least one dimension.

5. the method for intelligence computation personalization rational use of medicines time according to claim 1 to 3 a kind of, special Sign is that this method further comprises that drug uses pharmacy association attributes item packet involved in time and relevant factor database Include: medication purpose association attributes, patient of hypersensitivity's history association attributes, patient medication history association attributes, patient medication administration route The wherein at least one dimension of association attributes, patient medication related gene attribute.

6. the method for intelligence computation personalization rational use of medicines time according to claim 1 to 3 a kind of, special Sign is that this method further comprises that drug includes: using time-related attributes involved in time and relevant factor database With natural rhythm and pace of moving things correlation time attribute: year, month, day, in the daytime/night, the morning/morning/noon/afternoon/night/night, season； With correlation time in division of day and night attribute: hour, minute；With individual's work and rest rule of life correlation time attribute: getting up, before the meal/in meal/meal Afterwards, before sleeping；With the state of an illness/symptom/index correlation time attribute: body temperature is more than ... when spending, when pain, when dizziness, when nervous, nausea When；With patient's inspection/operation/operation correlation time attribute: before inspection, operation after, dressing when；It is relevant to patient's physiological period Time attribute: menstruation first day, menopause later six months；Time attribute relevant to patient's fertility: 24 hours, preparation after man and wife has sexual intercourse Be pregnant before March, pregnancy 24 weeks, produce after 3 days；With patient work/activity correlation time attribute: before by bus, before high-altitude application Wherein at least one dimension.

7. the method for intelligence computation personalization rational use of medicines time according to claim 1 to 3 a kind of, special Sign is that this method further comprises that drug uses time and relevant factor database, is capable of providing between two or more drugs The dictionary for needing patient's separated in time to use, including but not limited to: existing because drug interaction needs interval time to make With the case where, Pharmaceuticals is used together between the case where needing interval time, drug and needs to be spaced containing identical/similar component Time using the case where and other need the case where being spaced between drug using the time.

8. the method for intelligence computation personalization rational use of medicines time according to claim 1 to 3 a kind of, special It the step of sign is, this method further comprises, the setting of patient's daily schedule, set and is made according to the real life rule of patient Cease the time.

9. the method for intelligence computation personalization rational use of medicines time according to claim 1 to 3 a kind of, special Sign is that this method further comprises that doctor, pharmacist or sufferers themselves can be in the whole drug rational use of medicines time schemes of generation On the basis of, result audit and adjustment are carried out to patient personalized administration time scheme.

10. the method for intelligence computation personalization rational use of medicines time according to claim 1 to 3 a kind of, special Sign is that this method further comprises according to patient personalized whole drug rational use of medicines time scheme and reminding setting, system Meeting timed reminding patient uses drug.

11. the method for intelligence computation personalization rational use of medicines time according to claim 1 to 3 a kind of, special Sign is, this method further comprises, based on mobile phone, intelligent wearable device, intelligent medicine box, intelligent medicine box, call center, Wechat, short message, the application of doctor/pharmacists ' job station plurality of devices are supported.

12. the method for intelligence computation personalization rational use of medicines time according to claim 1 to 3 a kind of, special Sign is that this method further comprises that patient's rational use of medicines time scheme can be in doctor, pharmacist, nursing staff, family members and patient Between carry out data interaction, with guarantee patient under various conditions all can get effectively, timely medication remind.

13. the method for intelligence computation personalization rational use of medicines time according to claim 1 to 3 a kind of, special Sign is that this method further comprises the generation of the record and related statements of patient medication time scheme executive condition, so as to Doctor, pharmacist, reasonable personnel and sufferers themselves' analysis, adjustment and optimization treatment plan.

14. the method for intelligence computation personalization rational use of medicines time according to claim 1 to 3 a kind of, special Sign is that this method further comprises that patient medication relevant factor information extraction, association attributes are wanted when for extracting patient medication The actual information of element.

15. the method for intelligence computation personalization rational use of medicines time according to claim 1 to 3 a kind of, special Sign is, this method further comprises, the source of patient medication information be doctor formula, therapeutic scheme, therapeutic regimen, case history, Medical record, medicine go through, inspection result, patient's readme symptom, patient independently select medicine at least one of wherein.

16. the method for intelligence computation personalization rational use of medicines time according to claim 1 to 3 a kind of, special Sign is that this method is applied to C/S framework or B/S framework.

17. a kind of system of intelligence computation personalization rational use of medicines time, which is characterized in that the system comprises:

Drug is established using time correlation multidimensional attribute item dictionary unit, for using time and relevant factor according to drug Medicine or pharmacological properties structure and each attribute definition establish drug and use time correlation multidimensional attribute item dictionary；

Drug use time and relevant factor information extraction unit, for from package insert, pharmacopeia, national formulary, treatment/ In medicine guide, Consensus of experts and medical institutions' medication at different levels regulation, extracts drug and use time and relevant factor information；

Drug uses time and relevant factor information various dimensions processing unit, more using time and relevant factor information for drug Dimension processing；

Drug uses time and relevant factor Database Unit, for using every kind in time and relevant factor information according to drug The corresponding relationship using time and relevant factor information of drug establishes drug and uses time and relevant factor database, the data Library includes time-related attributes, medicine association attributes and pharmacy association attributes, and is capable of providing between two or more drugs and needs The dictionary for wanting patient's separated in time to use；

Drug uses time priority rank setup unit, which can be believed according to each group drug using time and relevant factor It ceases to patient safety, effective, economy, the significance level for being convenient to use drug, priority is carried out using the time to each group drug It does not set；

Patient medication relevant factor information extraction unit is used for the information extraction of patient medication relevant factor；

Patient medication relevant factor information various dimensions processing unit is handled for patient medication relevant factor information various dimensions；

Patient's daily schedule setup unit is set for patient's daily schedule；

Single drug rational use of medicines time generation unit, when for according to the work and rest of patient medication relevant factor information and patient Between, it is consistent from drug using inquiry, extraction in time and relevant factor database with patient's relevant medical, pharmacological properties The reasonable employment time of each drug used in patient, to realize that the single drug rational use of medicines time generates；

Patient's entirety drug rational use of medicines time schemes generation unit, for integrally using the kind of drug, each medicine according to patient The single drug reasonable employment time range of product needs to be spaced the drug used in drug and needs to be spaced the time used, Each drug generates patient's entirety drug rational use of medicines time scheme using time and the priority level of relevant factor；

Record, analysis and the reporting unit of the practical administration time of patient, for the practical administration time of patient record, analysis with And report.

18. the system of intelligence computation personalization rational use of medicines time according to claim 17 a kind of, which is characterized in that should System further comprises, based on mobile phone, intelligent wearable device, intelligent medicine box, intelligent medicine box, call center, wechat, short Letter, the application of doctor/pharmacists ' job station plurality of devices are supported.

19. the system of intelligence computation personalization rational use of medicines time according to claim 17 a kind of, which is characterized in that should System further comprises the setup unit of patient's daily schedule, sets the daily schedule according to the real life rule of patient.

20. a kind of system of intelligence computation personalization rational use of medicines time described in 7-19 any one according to claim 1, It is characterized in that, which further comprises that drug uses medicine association attributes item involved in time and relevant factor database Include: crowd's association attributes of patient, the special population association attributes of patient, the disease association attributes of patient, patient the past Medical history association attributes, patient operation association attributes, patient personal lifestyle history association attributes wherein at least one dimension.

21. a kind of system of intelligence computation personalization rational use of medicines time described in 7-19 any one according to claim 1, It is characterized in that, which further comprises that drug uses pharmacy association attributes item involved in time and relevant factor database Include: medication purpose association attributes, patient of hypersensitivity's history association attributes, patient medication history association attributes, patient medication administration way The wherein at least one dimension of diameter association attributes, patient medication related gene attribute.

22. a kind of system of intelligence computation personalization rational use of medicines time described in 7-19 any one according to claim 1, It is characterized in that, which further comprises that drug uses time-related attributes packet involved in time and relevant factor database Include: with natural rhythm and pace of moving things correlation time attribute: year, month, day, in the daytime/night, the morning/morning/noon/afternoon/night/night, season Section；With correlation time in division of day and night attribute: hour, minute；With individual's work and rest rule of life correlation time attribute: getting up, before the meal/meal In/it is postprandial, sleep before；With the state of an illness/symptom/index correlation time attribute: body temperature is more than ... when spending, when pain, when dizziness, palpitation When, nausea when；With patient's inspection/operation/operation correlation time attribute: before inspection, operation after, dressing when；With patient's physiology week Phase relevant time attribute: menstruation first day, menopause later six months；Time attribute relevant to patient's fertility: 24 after man and wife's the same branch of a family Hour, prepare be pregnant before March, pregnancy 24 weeks, produce after 3 days；With patient work/activity correlation time attribute: before by bus, high-altitude Preoperative wherein at least one dimension.

23. a kind of system of intelligence computation personalization rational use of medicines time described in 7-19 any one according to claim 1, Be characterized in that, which further comprises, drug uses time and relevant factor database, be capable of providing two or more drugs it Between need patient's separated in time to use dictionary, including but not limited to: exist because drug interaction need interval time The case where use, Pharmaceuticals, are used together between the case where needing interval time, drug containing between identical/similar component needs Every the time using the case where and other need the case where being spaced between drug using the time.

24. a kind of system of intelligence computation personalization rational use of medicines time described in 7-19 any one according to claim 1, It is characterized in that, which further comprises that doctor, pharmacist or sufferers themselves can be in the whole drug rational use of medicines time sides of generation On the basis of case, result audit and adjustment are carried out to patient personalized administration time scheme.

25. a kind of system of intelligence computation personalization rational use of medicines time described in 7-19 any one according to claim 1, It is characterized in that, which further comprises patient medication relevant information extraction unit, association attributes when for extracting patient medication The actual information of element.

26. a kind of system of intelligence computation personalization rational use of medicines time described in 7-19 any one according to claim 1, It is characterized in that, which further comprises being applied to C/S framework or B/S framework.

27. the system of intelligence computation personalization rational use of medicines time according to claim 17 a kind of, which is characterized in that should System further comprises that system is able to record the practical administration time of patient, and analyzes it and provide correlation report.

28. a kind of equipment of intelligence computation personalization rational use of medicines time, which is characterized in that the equipment includes:

Drug is established using time correlation multidimensional attribute item dictionary module, for using time and relevant factor according to drug Medicine or pharmacological properties structure and each attribute definition establish drug and use time correlation multidimensional attribute item dictionary；

Drug use time and relevant factor information extraction modules, for from package insert, pharmacopeia, national formulary, treatment/ In medicine guide, Consensus of experts and medical institutions' medication at different levels regulation, extracts drug and use time and relevant factor information；

Drug uses time and relevant factor information various dimensions processing module, more using time and relevant factor information for drug Dimension processing；

Drug uses time and relevant factor database module, for using every kind in time and relevant factor information according to drug The corresponding relationship using time and relevant factor information of drug establishes drug and uses time and relevant factor database, the data Library includes time-related attributes, medicine association attributes and pharmacy association attributes, and is capable of providing between two or more drugs and needs The dictionary for wanting patient's separated in time to use；

Drug uses time priority rank setting module, which can be believed according to each group drug using time and relevant factor It ceases to patient safety, effective, economy, the significance level for being convenient to use drug, priority is carried out using the time to each group drug It does not set；

Patient medication relevant factor information extraction modules are used for the information extraction of patient medication relevant factor；

Patient medication relevant factor information various dimensions processing module is handled for patient medication relevant factor information various dimensions；

Patient's daily schedule setting module is set for patient's daily schedule；

Single drug rational use of medicines time generation module, when for according to the work and rest of patient medication relevant factor information and patient Between, it is consistent from drug using inquiry, extraction in time and relevant factor database with patient's relevant medical, pharmacological properties The reasonable employment time of each drug used in patient, to realize that the single drug rational use of medicines time generates；

Patient's entirety drug rational use of medicines time schemes generation module, for integrally using the kind of drug, each medicine according to patient The single drug reasonable employment time range of product needs to be spaced the drug used in drug and needs to be spaced the time used, Each drug generates patient's entirety drug rational use of medicines time scheme using time and the priority level of relevant factor；

Record, analysis and the reporting modules of the practical administration time of patient, for the practical administration time of patient record, analysis with And report.

29. the equipment of intelligence computation personalization rational use of medicines time according to claim 28 a kind of, which is characterized in that should Equipment further comprises according to patient personalized administration time scheme and reminding setting, and system meeting timed reminding patient uses medicine Product.

30. the equipment of intelligence computation personalization rational use of medicines time according to claim 28 a kind of, which is characterized in that should Equipment further comprises the setting module of patient's daily schedule, sets the daily schedule according to the real life rule of patient.

31. the equipment of intelligence computation personalization rational use of medicines time according to claim 28 a kind of, which is characterized in that should Equipment further comprises, doctor, pharmacist or sufferers themselves can on the basis of the whole drug rational use of medicines time scheme of generation, Result audit and adjustment are carried out to patient personalized administration time scheme.

32. the equipment of intelligence computation personalization rational use of medicines time according to claim 28 a kind of, which is characterized in that should Equipment further comprises patient medication relevant factor information extraction modules, association attributes element when for extracting patient medication Actual information.

33. the equipment of intelligence computation personalization rational use of medicines time according to claim 28 a kind of, which is characterized in that should Equipment further comprises but is not limited to: mobile phone, intelligent wearable device, intelligent medicine box, intelligent medicine box, call center, doctor/ Pharmacists ' job station plurality of devices, and can support but be not limited to: short message, wechat, voice, audio communication, optical signal, vibration signal is a variety of mentions The mode of waking up.