CN104529860A - 一种含硝基苯和二烯氟代金刚烷结构的化合物及制备方法 - Google Patents
一种含硝基苯和二烯氟代金刚烷结构的化合物及制备方法 Download PDFInfo
- Publication number
- CN104529860A CN104529860A CN201510017467.1A CN201510017467A CN104529860A CN 104529860 A CN104529860 A CN 104529860A CN 201510017467 A CN201510017467 A CN 201510017467A CN 104529860 A CN104529860 A CN 104529860A
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- CN
- China
- Prior art keywords
- compound
- diene
- lithium
- hexamethyl
- nitrogen base
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *CCC(CC(CCC1)C2)CC12F Chemical compound *CCC(CC(CCC1)C2)CC12F 0.000 description 1
- PJYFCYBLMKTMNP-UHFFFAOYSA-N CC(CC(C1)C2)(CC1C1)CC21F Chemical compound CC(CC(C1)C2)(CC1C1)CC21F PJYFCYBLMKTMNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
化合物 | 血小板凝聚的抑制IC50(μM) |
化合物I | 0.29 |
参比化合物D1 | 0.87 |
Claims (4)
Priority Applications (1)
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CN201510017467.1A CN104529860B (zh) | 2015-01-13 | 2015-01-13 | 一种含硝基苯和二烯氟代金刚烷结构的化合物及制备方法 |
Applications Claiming Priority (1)
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CN201510017467.1A CN104529860B (zh) | 2015-01-13 | 2015-01-13 | 一种含硝基苯和二烯氟代金刚烷结构的化合物及制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN104529860A true CN104529860A (zh) | 2015-04-22 |
CN104529860B CN104529860B (zh) | 2016-06-01 |
Family
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Family Applications (1)
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CN201510017467.1A Active CN104529860B (zh) | 2015-01-13 | 2015-01-13 | 一种含硝基苯和二烯氟代金刚烷结构的化合物及制备方法 |
Country Status (1)
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CN (1) | CN104529860B (zh) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101472907A (zh) * | 2006-06-19 | 2009-07-01 | 皮埃尔法布雷医药公司 | 肉桂酰基-哌嗪衍生物及其作为par-1拮抗剂的用途 |
WO2012040636A2 (en) * | 2010-09-24 | 2012-03-29 | The Broad Institute, Inc. | Compounds and methods for treating diseases mediated by protease activated receptors |
CN104072436A (zh) * | 2014-07-23 | 2014-10-01 | 张远强 | 对位取代的四氮唑苯乙酮化合物、其制备方法和用途 |
-
2015
- 2015-01-13 CN CN201510017467.1A patent/CN104529860B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101472907A (zh) * | 2006-06-19 | 2009-07-01 | 皮埃尔法布雷医药公司 | 肉桂酰基-哌嗪衍生物及其作为par-1拮抗剂的用途 |
WO2012040636A2 (en) * | 2010-09-24 | 2012-03-29 | The Broad Institute, Inc. | Compounds and methods for treating diseases mediated by protease activated receptors |
CN104072436A (zh) * | 2014-07-23 | 2014-10-01 | 张远强 | 对位取代的四氮唑苯乙酮化合物、其制备方法和用途 |
Also Published As
Publication number | Publication date |
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CN104529860B (zh) | 2016-06-01 |
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PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Compound containing nitrobenzene and diene fluoro adamantane structure and preparation method thereof Effective date of registration: 20170816 Granted publication date: 20160601 Pledgee: Guangdong Nanhai Rural Commercial Bank branch branch of Limited by Share Ltd Pledgor: FOSHAN SAIWEISI PHARMACEUTICAL TECHNOLOGY CO., LTD. Registration number: 2017990000756 |
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Date of cancellation: 20190604 Granted publication date: 20160601 Pledgee: Guangdong Nanhai Rural Commercial Bank branch branch of Limited by Share Ltd Pledgor: FOSHAN SAIWEISI PHARMACEUTICAL TECHNOLOGY CO., LTD. Registration number: 2017990000756 |
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Effective date of registration: 20191028 Address after: 221300 north side of Qingnian East Road, Yunhe Town, Pizhou City, Xuzhou City, Jiangsu Province Patentee after: Pizhou Runhong Industry Co., Ltd. Address before: Chancheng district has 528000 Taiwan public in Guangdong province Foshan City No. 32 first floor 1636, shop No. 1637 Patentee before: FOSHAN SAIWEISI PHARMACEUTICAL TECHNOLOGY CO., LTD. |
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