CN104524527A - 一种治疗痢疾的凤尾草中药制剂及其制备方法 - Google Patents
一种治疗痢疾的凤尾草中药制剂及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗痢疾的凤尾草中药制剂及其制备方法，由凤尾草、葛根、黄连、夏枯草、鱼腥草、仙鹤草、刺梨根、艾叶、桔梗、苦瓜、麦门冬、车前草、生姜、铁苋菜、地榆、白芍、薏苡份和金银花配制而成。本发明凤尾草中药汤剂以凤尾草为主药，搭配其他辅药，各种药互相作用，对缓解腹痛腹泻、痢疾白多赤少有显著疗效，本药物突出的效果是无毒副作用，效果显著，而且还有清热解毒以及舒肝理气等作用，从根本上解除了患者的痛苦。
Description
技术领域
本发明涉及中药领域，具体是一种治疗痢疾的凤尾草中药制剂及其制备方法。
背景技术
痢疾病是一种常见的肠道疾病，其临床表现是腹痛腹泻频繁，大便中带有红白相杂的粘稠脓状物，腹痛下坠，便急，便频，发热，病情有急性和慢性之分；目前，西医治疗痢疾常采用氟呱酸、庆大霉素、黄连素和复方新诺明，虽然这些西药有一定的疗效，但也有一定的副作用；中医治疗痢疾常用芍药汤、骨答汤或白头翁汤等，副作用小，但疗效不是十分理想。
发明内容
本发明的目的在于提供一种药效作用好的治疗痢疾的凤尾草中药制剂及其制备方法，以解决上述背景技术中提出的问题。
为实现上述目的，本发明提供如下技术方案：
一种治疗痢疾的凤尾草中药制剂，由以下重量份的原料配制而成：凤尾草90～100份、葛根20～30份、黄连15～25份、夏枯草25～35份、鱼腥草20～30份、仙鹤草20～25份、刺梨根10～20份、艾叶10～20份、桔梗5～15份、苦瓜30～40份、麦门冬25～35份、车前草20～30份、生姜5～10份、铁苋菜30～40份、地榆20～25份、白芍30～40份、薏苡35～45份、金银花30～40份。
一种治疗痢疾的凤尾草中药制剂的制备方法，具体步骤如下：（1）将葛根、刺梨根、桔梗、苦瓜和生姜进行切片，然后放入90～95℃的烘干箱内烘干3～4h，取出备用；（2）在凤尾草、夏枯草、鱼腥草、仙鹤草、艾叶、麦门冬、车前草、铁苋菜、白芍和金银花中加入8～10倍原料的蒸馏水，先用武火加热煮沸20～30min，再用文火煎煮2～3h，然后再加入4～6倍原料的蒸馏水，继续用文火煎煮2～3h，冷却至室温后过滤得到药液A备用；（3）在葛根、黄连、刺梨根、桔梗、生姜、地榆和薏苡中加入10～12倍原料的蒸馏水，先用武火加热煮沸20～30min，再用文火煎煮4～5h，冷却至室温后过滤得到药液B备用；（4）将药液A加入药液B中，再加入混合液2倍的蒸馏水加热40～45min，加热温度为80～90℃，然后自然冷却至室温，经过精细过滤再进行紫外线消毒杀菌，真空计量装瓶，即可得到治疗痢疾的凤尾草中药制剂。
药理作用：凤尾草：具有清热利湿和解毒止痢的作用，可用于治疗痢疾、腹泻和胃肠炎；葛根：具有阴虚消渴、热泄热痢和脾虚泄泻的作用；黄连：具有治疗痢疾及腹泻的作用；夏枯草：对腹痛、痢疾及腹泻具有很好的治疗作用；鱼腥草：清热解毒，能治疗热痢热疾的病症；仙鹤草：解毒止痢，对痢疾、疟疾具有很好的治疗作用；刺梨根：能消食止泻，对腹泻、痢疾具有很好的治疗作用；艾叶：对寒湿腹泻痢疾具有很好的治疗作用；桔梗：具有抗菌抗炎作用，能促进血液循环以及抗胃疡作用；苦瓜：含有的苦瓜甙和苦味素能增加食欲，健脾开胃，含有的生物碱类物质奎宁有利尿活血、消炎退热及清心明目的功效；麦门冬：解毒清热，益胃生津，清养肺胃；车前草：清热解毒，清养肺胃；生姜：对消化道有轻度刺激作用，使得肠张力、节律及蠕动增加，并促进人体血液循环，对各种胃肠病菌有一定的抑制作用；铁苋菜：清热解毒，对细菌性痢疾及疟疾有很好的治疗作用；地榆：具有清热解毒、治疗痢疾的作用；白芍：具有抗菌的作用，对葡萄球菌有一定抑制作用，能治疗痢疾病症；薏苡：具有清热排毒、治疗腹泻及痢疾的作用；金银花：具有清热解毒、治疗痢疾的作用。
与现有技术相比，本发明的有益效果是：本发明凤尾草中药汤剂以凤尾草为主药，搭配其他辅药，各种药互相作用，对缓解腹痛腹泻、痢疾白多赤少有显著疗效，本药物突出的效果是无毒副作用，效果显著，而且还有清热解毒以及舒肝理气等作用，从根本上解除了患者的痛苦。
具体实施方式
下面将结合本发明实施例，对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
实施例1
一种治疗痢疾的凤尾草中药制剂，由以下重量份的原料配制而成：凤尾草90份、葛根20份、黄连15份、夏枯草25份、鱼腥草20份、仙鹤草20份、刺梨根10份、艾叶10份、桔梗5份、苦瓜30份、麦门冬25份、车前草20份、生姜5份、铁苋菜30份、地榆20份、白芍30份、薏苡35份、金银花30份。
上述治疗痢疾的凤尾草中药制剂的制备方法，具体步骤如下：（1）将葛根、刺梨根、桔梗、苦瓜和生姜进行切片，然后放入95℃的烘干箱内烘干4h，取出备用；（2）在凤尾草、夏枯草、鱼腥草、仙鹤草、艾叶、麦门冬、车前草、铁苋菜、白芍和金银花中加入8倍原料的蒸馏水，先用武火加热煮沸30min，再用文火煎煮3h，然后再加入4倍原料的蒸馏水，继续用文火煎煮3h，冷却至室温后过滤得到药液A备用；（3）在葛根、黄连、刺梨根、桔梗、生姜、地榆和薏苡中加入12倍原料的蒸馏水，先用武火加热煮沸30min，再用文火煎煮5h，冷却至室温后过滤得到药液B备用；（4）将药液A加入药液B中，再加入混合液2倍的蒸馏水加热40min，加热温度为80℃，然后自然冷却至室温，经过精细过滤再进行紫外线消毒杀菌，真空计量装瓶，即可得到治疗痢疾的凤尾草中药制剂。
实施例2
一种治疗痢疾的凤尾草中药制剂，由以下重量份的原料配制而成：凤尾草93份、葛根24份、黄连18份、夏枯草32份、鱼腥草27份、仙鹤草24份、刺梨根16份、艾叶14份、桔梗8份、苦瓜33份、麦门冬28份、车前草24份、生姜7份、铁苋菜34份、地榆22份、白芍37份、薏苡38份、金银花33份。
上述治疗痢疾的凤尾草中药制剂的制备方法，具体步骤如下：（1）将葛根、刺梨根、桔梗、苦瓜和生姜进行切片，然后放入95℃的烘干箱内烘干4h，取出备用；（2）在凤尾草、夏枯草、鱼腥草、仙鹤草、艾叶、麦门冬、车前草、铁苋菜、白芍和金银花中加入9倍原料的蒸馏水，先用武火加热煮沸30min，再用文火煎煮3h，然后再加入5倍原料的蒸馏水，继续用文火煎煮3h，冷却至室温后过滤得到药液A备用；（3）在葛根、黄连、刺梨根、桔梗、生姜、地榆和薏苡中加入11倍原料的蒸馏水，先用武火加热煮沸30min，再用文火煎煮5h，冷却至室温后过滤得到药液B备用；（4）将药液A加入药液B中，再加入混合液2倍的蒸馏水加热40min，加热温度为80℃，然后自然冷却至室温，经过精细过滤再进行紫外线消毒杀菌，真空计量装瓶，即可得到治疗痢疾的凤尾草中药制剂。
实施例3
一种治疗痢疾的凤尾草中药制剂，由以下重量份的原料配制而成：凤尾草97份、葛根27份、黄连22份、夏枯草28份、鱼腥草23份、仙鹤草28份、刺梨根13份、艾叶18份、桔梗13份、苦瓜38份、麦门冬32份、车前草27份、生姜9份、铁苋菜38份、地榆23份、白芍33份、薏苡42份、金银花37份。
上述治疗痢疾的凤尾草中药制剂的制备方法，具体步骤如下：（1）将葛根、刺梨根、桔梗、苦瓜和生姜进行切片，然后放入95℃的烘干箱内烘干4h，取出备用；（2）在凤尾草、夏枯草、鱼腥草、仙鹤草、艾叶、麦门冬、车前草、铁苋菜、白芍和金银花中加入9倍原料的蒸馏水，先用武火加热煮沸30min，再用文火煎煮3h，然后再加入5倍原料的蒸馏水，继续用文火煎煮3h，冷却至室温后过滤得到药液A备用；（3）在葛根、黄连、刺梨根、桔梗、生姜、地榆和薏苡中加入11倍原料的蒸馏水，先用武火加热煮沸30min，再用文火煎煮5h，冷却至室温后过滤得到药液B备用；（4）将药液A加入药液B中，再加入混合液2倍的蒸馏水加热40min，加热温度为80℃，然后自然冷却至室温，经过精细过滤再进行紫外线消毒杀菌，真空计量装瓶，即可得到治疗痢疾的凤尾草中药制剂。
实施例4
一种治疗痢疾的凤尾草中药制剂，由以下重量份的原料配制而成：凤尾草100份、葛根30份、黄连25份、夏枯草35份、鱼腥草30份、仙鹤草25份、刺梨根20份、艾叶20份、桔梗15份、苦瓜40份、麦门冬35份、车前草30份、生姜10份、铁苋菜40份、地榆25份、白芍40份、薏苡45份、金银花40份。
上述治疗痢疾的凤尾草中药制剂的制备方法，具体步骤如下：（1）将葛根、刺梨根、桔梗、苦瓜和生姜进行切片，然后放入95℃的烘干箱内烘干4h，取出备用；（2）在凤尾草、夏枯草、鱼腥草、仙鹤草、艾叶、麦门冬、车前草、铁苋菜、白芍和金银花中加入10倍原料的蒸馏水，先用武火加热煮沸30min，再用文火煎煮3h，然后再加入6倍原料的蒸馏水，继续用文火煎煮3h，冷却至室温后过滤得到药液A备用；（3）在葛根、黄连、刺梨根、桔梗、生姜、地榆和薏苡中加入12倍原料的蒸馏水，先用武火加热煮沸30min，再用文火煎煮5h，冷却至室温后过滤得到药液B备用；（4）将药液A加入药液B中，再加入混合液2倍的蒸馏水加热40min，加热温度为80℃，然后自然冷却至室温，经过精细过滤再进行紫外线消毒杀菌，真空计量装瓶，即可得到治疗痢疾的凤尾草中药制剂。
实施例5
临床试验
（1）试验对象：采用本发明共治疗100例患者，其中男60例，女40例；年龄最大者60岁，年龄最小者15岁；患者症状：痢疾下面赤白牯冻，白多赤少，腹痛腹泻，大便脓血，里急后重，头身困重，舌质淡苔白腻。
（2）治疗方法:每天饭前服用，每日三次，一次服用量为15ml，7天一疗程。
（3）治疗标准
治愈：临床腹泻痢疾症状完全消失；
好转：临床症状减轻，体征改善；
无效：用药前后症状无改变。
（4）治疗结果：患者100例病例中服药在1-2天的有85例症状完全消失；临床症状减轻者10例，临床症状无改变者5例，总有效率达95%，未见不良反应。
典型病例：
病例1：陈某，男，54岁，腹痛，发烧，腹泻便急，大便中有白色粘稠脓状物，每天大便5-7次，确诊为痢疾，服用本发明中药2天，大便次数减少，症状减轻，继续服用本发明的中药3天，症状消失，病情痊愈。
病例2：崔某，男，45岁，腹痛，腹泻便急，大便脓血，大便每天达10余次，确诊为痢疾，服用本发明中药3天，大便次数减少，腹痛减轻，症状明显减轻，继续服用本发明的中药5天，症状消失，病情痊愈。
病例3：
张某，女，40岁，腹痛，腹泻便急，大便中有白色粘稠脓状物，确诊为痢疾，服用本发明中药2天，大便次数减少，无明显腹痛，继续服用本发明的中药2天，症状消失，痊愈。
病例4：蔡某，女，30岁，腹痛，腹泻便急，大便每天3-6次，确诊为痢疾，服用本发明中药2天，大便次数减少，腹痛减轻，继续服用本发明的中药2天，症状消失，病情痊愈。
Claims (2)
1.一种治疗痢疾的凤尾草中药制剂，其特征在于，由以下重量份的原料配制而成：凤尾草90～100份、葛根20～30份、黄连15～25份、夏枯草25～35份、鱼腥草20～30份、仙鹤草20～25份、刺梨根10～20份、艾叶10～20份、桔梗5～15份、苦瓜30～40份、麦门冬25～35份、车前草20～30份、生姜5～10份、铁苋菜30～40份、地榆20～25份、白芍30～40份、薏苡35～45份、金银花30～40份。
2.根据权利要求1所述的治疗痢疾的凤尾草中药制剂的制备方法，其特征在于，具体步骤如下：（1）将葛根、刺梨根、桔梗、苦瓜和生姜进行切片，然后放入90～95℃的烘干箱内烘干3～4h，取出备用；（2）在凤尾草、夏枯草、鱼腥草、仙鹤草、艾叶、麦门冬、车前草、铁苋菜、白芍和金银花中加入8～10倍原料的蒸馏水，先用武火加热煮沸20～30min，再用文火煎煮2～3h，然后再加入4～6倍原料的蒸馏水，继续用文火煎煮2～3h，冷却至室温后过滤得到药液A备用；（3）在葛根、黄连、刺梨根、桔梗、生姜、地榆和薏苡中加入10～12倍原料的蒸馏水，先用武火加热煮沸20～30min，再用文火煎煮4～5h，冷却至室温后过滤得到药液B备用；（4）将药液A加入药液B中，再加入混合液2倍的蒸馏水加热40～45min，加热温度为80～90℃，然后自然冷却至室温，经过精细过滤再进行紫外线消毒杀菌，真空计量装瓶，即可得到治疗痢疾的凤尾草中药制剂。
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| CN104873928A (zh) * | 2015-05-17 | 2015-09-02 | 陈迎霞 | 一种治疗痢疾的旱莲草制剂及其制备方法 |
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