CN104524320B - 一种茶花烫伤药 - Google Patents
一种茶花烫伤药 Download PDFInfo
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- CN104524320B CN104524320B CN201510052969.8A CN201510052969A CN104524320B CN 104524320 B CN104524320 B CN 104524320B CN 201510052969 A CN201510052969 A CN 201510052969A CN 104524320 B CN104524320 B CN 104524320B
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- coptis
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- camellia
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Landscapes
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Abstract
本发明公开的一种茶花烫伤药,涉及外用中成药制备技术领域,是由以下重量份的原料制备而成:鲜茶花45‑65、茶油4‑7、丝瓜茸10‑18、淡竹叶5‑10、黄连2‑5、芙蓉叶1.5‑3.5、地榆1‑4、甘草2‑5、络石藤2.5‑5.5;其制备过程如下:㈠、备料;㈡、原料预处理:①、鲜茶花预处理;②、甘草预处理;③、淡竹叶预处理;④、黄连预处理;⑤、芙蓉叶预处理;⑥、地榆预处理;⑦、络石藤预处理;㈢、配制:A、干粉一制备;B、干粉二制备;C、初混合;D、制膏。具有清凉、解热、消红、退肿、保湿、滋润和抗菌消炎等功效,对烧烫伤有较好治疗作用等特点;适用于治疗各种程度的烧烫伤,对刀伤和擦碰伤也有较好的治疗效果。
Description
技术领域
本发明涉及外用中成药制备技术领域,特别是一种茶花烫伤药。
背景技术
烧烫伤是人们经常遇到的意外损伤,社会越是向工业化发展,各种原因所致的烧烫伤发生率越高。目前,治疗烧烫伤的药物种类繁多,西药首推磺胺嘧啶银,中成药中较有影响的为湿润烧伤膏。
中国专利(申请号为201010117467.6)公开的“一种治疗烧伤烫伤的中药膏剂”,是由蛇油、麻油、蛋黄油、白芷、虎杖、草木灰、黄连、薄荷、茶油、冰片、地榆11种原料,通过将白芷、虎杖、薄荷、黄连、冰片、地榆粉碎后加入到麻油和茶油的混合液中,并加热至沸腾后用文火熬制3小时,然后加入蛇油、蛋黄油和草木灰并搅拌均匀,冷却至常温制得的膏剂成品;该发明具有对烧烫伤创面治愈快,不需消痂植皮,治愈后不留疤痕,治疗条件要求低,不强调无菌环境和无菌操作;具有清热、解毒、消肿止痛,收敛生肌,使用方便,制造简单,治疗费用低的特点;解决了现有治疗烧、烫伤的药物治疗时间长,费用高,愈后易留有疤痕的问题;对于皮肤冻伤、溃烂也有特殊的疗效。又如中国专利(申请号为200610017993.9)公开的“治疗烧烫伤的药物”,由以重量份为单位的下列各组分组成:虎杖250~350份,地榆280~320份,大黄250~350份,黄连250~350份,五倍子50~150份,松萝80~120份,血竭80~150份,冰片50~120份,蛇莓300~400份,山茶花280~320份,蚕豆荚300~350份,木芙蓉250~350份,白芨150~250份,细辛120~220份,白芷100~300份,甘草160~250份;该发明治疗烧烫伤的药物是从祖国传统医药宝库中筛选出的具有发散热毒、活血化淤、消肿止痛、化腐解毒、生肌敛皮、抗纤维化、减少渗出并促进创面迅速愈合之功效的纯天然中药精制而成,成本低、使用方便效果好,是单位、家庭必备的良药。
发明内容
本发明的目的在于提供一种具有清凉、解热、消红、退肿、保湿、滋润和抗菌消炎等功效,对烧烫伤有较好治疗作用的药物。
为实现上述目的,本发明所采取的技术措施是发明一种茶花烫伤药,是由以下重量份的原料制备而成:
鲜茶花45-65 茶油4-7 丝瓜茸10-18
淡竹叶5-10 黄连2-5 芙蓉叶1.5-3.5
地榆1-4 甘草2-5 络石藤2.5-5.5;
其制备过程如下:
㈠、备料:按照上述重量份,分别称取各原料,备用;
㈡、原料预处理:
①、鲜茶花预处理:将无虫害的新鲜茶花,放入清水中洗涤3-6次,捞出,研磨处理成60-100目的细料,然后压滤,分别收集茶花滤液和茶花滤渣,备用;再将备用的茶花滤渣与占其重量2-4倍、体积浓度为55-78%的食用乙醇在1-10℃下混合,静置处理3-5h、并每隔30min沿顺时针方向搅拌2-5min,过滤,收集醇提茶花溶液;再将醇提茶花溶液在压力为10-18KPa、温度为32-49℃下浓缩至溶液中的醇度为30-36%(即:让溶液中的乙醇挥发一部分,至溶液中乙醇的体积浓度为30-36%),得粗浓缩液;然后将粗浓缩液和备用的茶花滤液合并,搅拌30-45min,接着加入占原鲜茶花重量12-20%的红糖,再按1-2℃/min的升温速度边搅拌边加热至40-58℃,然后放置在4-10℃的环境里降至18-20℃时,过滤,收集上层溶液;再将上层溶液在压力为8-12KPa、温度为50-68℃下浓缩至无醇,得浓缩液;再向浓缩液中加入占原鲜茶花重量1.5-3.5%的茶多酚(所用的茶多酚,其含量通常为85-98%),搅拌至完全溶解,然后,经3000-5000转/min的高速离心机离心处理,收集上层澄清液,即得鲜茶花澄清液,备用;
②、甘草预处理:将新鲜、无腐烂、无虫害的甘草,洗净,与占其重量35-45%的清水处理成100-150目的浆料,然后压滤,分别收集甘草水液和甘草渣,备用;再向备用的甘草渣中加入占其重量1.2-1.85%的果胶酶、3.5-6.0%的纤维素酶、0.5-0.85%的蛋白酶,同时加入占其重量10-25%、35-40℃的水稀释,密封处理15-20h,再用150-250目的纱布过滤,收集甘草酶解滤渣;然后,将甘草酶解滤渣在常温下经均质机处理成200-300目的甘草酶解滤渣浆料,再将甘草酶解滤渣浆料和备用的甘草水液合并,在压力为5-8KPa、温度为60-78℃下浓缩至固形物含量为1.2-1.56mg/10ml,即得甘草浓缩液,备用;
③、淡竹叶预处理:将新鲜的淡竹叶,洗净,投入占其重量1-3倍、体积浓度为65-85%的食用乙醇中,在10-25℃下浸泡1-2.5天,过滤,收集淡竹叶醇提液;再向淡竹叶醇提液中加入清水,使其醇度降至20-30%,并用浓度为10-15%的无机酸(所用的无机酸为磷酸、稀盐酸中的一种)溶液调节其pH值至4.5-5.0,然后在0-10℃下静放至完全沉淀,过滤,分别收集沉淀和上清液,备用;再将备用的上清液在压力为5-8KPa、温度为60-78℃下浓缩至无醇,然后转移至冷库中,在-4~4℃下静放至完全沉淀,过滤,收集二次沉淀;将二次沉淀与备用的沉淀合并,干燥、粉碎,即得淡竹叶粉,备用;
④、黄连预处理:将黄连洗净,投入同等重量的沸水中,煎煮30-45min,过滤,得水煮黄连;再将水煮黄连处理成100-160目的细料,并向细料中加入占其重量2-4倍、体积浓度为50-70%的食用乙醇,在常温常压下浸泡12-16h,过滤,收集黄连醇提液;再向黄连醇提液中加入清水,使醇度降至30-35%,然后在0-10℃下静放10-15h,过滤,收集上层的黄连溶液;再将黄连溶液在压力为5-8KPa、温度为60-78℃下浓缩至无醇,再加入占原黄连重量5.5-9.5%的麦芽糊精,搅匀,在压力为5-8KPa、温度为60-78℃下浓缩至固形物含量为1.8-3.5mg/10ml,即得黄连液,备用;
⑤、芙蓉叶预处理:将新鲜的芙蓉叶,洗净,与同等重量的热水一起处理成60-100目的浆汁,再经压滤,收集芙蓉叶汁液;将芙蓉叶汁液在压力为5-8KPa、温度为60-78℃下浓缩至原体积的1/4-1/2,即得芙蓉叶汁,备用;
⑥、地榆预处理:将新鲜的地榆,洗净,切成厚度为0.15-0.25cm的片状,投入占其重量2-4倍的沸水中,煎煮30-55min,过滤,收集水煮地榆,然后将水煮地榆在60-70℃下干燥至水分小于8.0%,得地榆片;再将地榆片经超微粉碎,过孔径为15-35nm的筛,即得地榆细粉,备用;
⑦、络石藤预处理:将新鲜的络石藤,洗净,投入占其重量2-4倍、体积浓度为70-80%的食用乙醇中,回流提取3.0-6.0h,过滤,得络石藤醇提液;再向络石藤醇提液中加入40-50℃的水,使其醇度降至35-45%,然后在40-50℃下过极性大孔树脂柱(型号为ADS-21树脂),上柱的流速为5-9L/h,再用相当于2-2.5个柱体积的有机溶剂(所用的有机溶剂为乙醇、80%的甲醇、乙酸乙酯中的一种)洗脱,洗脱液的流速为3-5L/h,收集洗脱液;再将洗脱液在压力为5-8KPa、温度为40-55℃下浓缩至原体积的1/2,接着加入同等体积的清水,并加入占原络石藤重量1.5-3.5%的吐温60,搅匀,在压力为5-8KPa、温度为60-78℃下浓缩至木犀草素的含量为10.5-16.5mg/ml,得络石藤浓缩液,备用;
㈢、配制:
A、干粉一制备:将备用的黄连液和络石藤浓缩液混匀,经喷雾干燥,得干粉一,备用;
B、干粉二制备:将备用的甘草浓缩液、芙蓉叶汁混合,经喷雾干燥,得干粉二,备用;
C、初混合:将备用的干粉一、干粉二、淡竹叶粉、地榆细粉、丝瓜茸、茶油一起混合,经均质机反复处理2-4次,收集均匀的初混细粉,备用;
D、制膏:将备用的初混细粉投入备用的鲜茶花澄清液中,同时加入占初混细粉重量0.5-1.25%的植物胶(所用的植物胶为阿拉伯树胶、瓜尔豆胶、黄原胶中的一种)搅匀,经均质机反复处理2-4次,收集均匀的膏状物,然后将其与同等重量的凡士林或医药热熔胶加热混合均匀,即成茶花烫伤药。
本发明的茶花烫伤药为药膏状,使用时,可将其均匀涂于纱布或绢布上,制成可外敷的贴药,也可直接将其涂敷在患处。
其优化的技术方案一是由以下重量份的原料制备而成:
鲜茶花45 茶油7 丝瓜茸18
淡竹叶10 黄连5 芙蓉叶3.5
地榆1 甘草2 络石藤5.5。
其优化的技术方案二是由以下重量份的原料制备而成:
鲜茶花65 茶油4 丝瓜茸10
淡竹叶5 黄连2 芙蓉叶1.5
地榆4 甘草5 络石藤2.5。
其优化的技术方案三是由以下重量份的原料制备而成:
鲜茶花55 茶油5 丝瓜茸15
淡竹叶8 黄连4 芙蓉叶2
地榆3 甘草3 络石藤4。
本发明的茶花烫伤药是由鲜茶花、茶油、丝瓜茸、淡竹叶、黄连、芙蓉叶、地榆、甘草和络石藤制备而成,还添加有茶多酚。所用的鲜茶花(Camellia olelfera Abel[C.oleosa(Lour.) Rehd.])凉血止血。茶油(Camellia oleifera Abel)富含维生素E,还含有角鲨烯、茶多酚、茶皂素等黄酮类物质,对抗炎有着极佳的作用,外用能消红、退肿,且具有保湿、滋润,是制作针剂和调制各种药膏、药丸的上佳原料。丝瓜茸(Luffa cylindrica,此处的丝瓜茸是指老丝瓜剥去外表皮后,内部成茸状的丝瓜肉)具有清热化痰、凉血解毒之功效。淡竹叶(Lophatherum gracile)有清凉、解热功效。黄连(Coptis chinensis Franch.)清热燥湿、泻火解毒,有抗菌、抗真菌、抗炎和抗溃疡作用。芙蓉叶(Folium Hibisci Mutabilis)有凉血止血、清热解毒、活血消肿的功效,是治疗烫伤的上佳药物。地榆(Sanguisorbaofficinalis)凉血止血、解毒敛疮,用于水火烫伤、痈肿疮毒。甘草(Glycyrrhizauralensis Fisch)别名国老,用于调和某些药物的烈性,还有抗炎和抗过敏作用。络石藤(rachelospermumjasminoides.)有祛风通络,凉血消肿功能。茶多酚(Tea Polyphenols)具有较强的抗氧化能力,具有消毒、灭菌、抗皮肤老化和抗皮肤过敏反应等功效。上述诸药合用,使得本发明的茶花烫伤药具有清凉、解热、消红、退肿、保湿、滋润和抗菌消炎等功效,对烧烫伤有较好治疗作用;同时,对于一些刀伤和擦碰伤,也有较好的治疗效果。
本发明的茶花烫伤药,曾针对不同病情和年龄的烧烫伤患者60例,进行过治疗试验。
1、一般资料
在60例烧烫伤患者中,男34例,女26例;年龄最小12岁,最大44岁,平均年龄28岁;烧烫伤面积:最小2.5%TBSA,最大42.5%TBSA;15%TBSA以下50例,15%TBSA~30%TBSA 6例,31%TBSA~40%TBSA3例,41%TBSA以上1例;烧烫伤深度分布:浅二度为主者48例,深二度为主者10例,三度为主者2例;烧烫伤原因:火焰烧伤4例,热液烫伤35例;热固体烫伤21例。
2、试验方法
⑴、治疗用药:采用前述优化的技术方案三(按重量份配方为:鲜茶花55份、茶油5份、丝瓜茸15份、淡竹叶8份、黄连4份、芙蓉叶2份、地榆3份、甘草3份、络石藤4份),并按前述方法制备成茶花烫伤药。
⑵、治疗方法:先用3%双氧水清洗患部,并用针头刺破水泡,剪去已游离腐皮,用0.2%新洁而灭消毒,然后,将本发明的茶花烫伤药涂于患处,用纱布包扎固定,3-5天更换一次药。每4天为一个疗程,大多数病例在3-9个疗程内痊愈。治疗期间,患处禁搔抓,忌食辛辣刺激食品。
3、疗效判定标准
①、治愈:全身症状消失,创面愈合。
②、好转:全身症状消失,创面完全愈合。
③、无效:全身症状见改善,创面感染不能控制。
治愈和好转,按有效统计。
4、试验效果
下表为试验(治疗)效果统计表:
上表数据显示,治愈35例,占58.3%;好转23例,占38.4%;无效2例,占3.3%;总有效率96.7%。因此,本发明的茶花烫伤药,对三度以下的烧烫伤有较好的治疗效果。
具体实施方式
以下结合实施例,对本发明作进一步的说明。下面的说明是以例举的方式,但本发明的保护范围并不局限于此。
实施例一:
本实施例的茶花烫伤药,是由以下重量份的原料制备而成:
鲜茶花45 茶油7 丝瓜茸18
淡竹叶10 黄连5 芙蓉叶3.5
地榆1 甘草2 络石藤5.5;
其制备过程如下:
㈠、备料:按照上述重量份,分别称取各原料,备用;
㈡、原料预处理:
①、鲜茶花预处理:将无虫害的新鲜茶花,放入清水中洗涤4次,捞出,研磨处理成80目的细料,然后压滤,分别收集茶花滤液和茶花滤渣,备用;再将备用的茶花滤渣与占其重量3倍、体积浓度为65%的食用乙醇在5℃下混合,静置处理4h、并每隔30min沿顺时针方向搅拌3min,过滤,收集醇提茶花溶液;再将醇提茶花溶液在压力为15KPa、温度为40℃下浓缩至溶液中的醇度为33%,得粗浓缩液;然后将粗浓缩液和备用的茶花滤液合并,搅拌40min,接着加入占原鲜茶花重量15%的红糖,再按2℃/min的升温速度边搅拌边加热至50℃,然后放置在6℃的环境里降至18℃时,过滤,收集上层溶液;再将上层溶液在压力为10KPa、温度为60℃下浓缩至无醇,得浓缩液;再向浓缩液中加入占原鲜茶花重量2.5%的茶多酚(所用的茶多酚含量为90%),搅拌至完全溶解,然后,经4000转/min的高速离心机离心处理,收集上层澄清液,即得鲜茶花澄清液,备用;
②、甘草预处理:将新鲜、无腐烂、无虫害的甘草,洗净,与占其重量40%的清水处理成120目的浆料,然后压滤,分别收集甘草水液和甘草渣,备用;再向备用的甘草渣中加入占其重量1.5%的果胶酶、4.8%的纤维素酶、0.7%的蛋白酶,同时加入占其重量20%、38℃的水稀释,密封处理18h,再用200目的纱布过滤,收集甘草酶解滤渣;然后,将甘草酶解滤渣在常温下经均质机处理成250目的甘草酶解滤渣浆料,再将甘草酶解滤渣浆料和备用的甘草水液合并,在压力为6KPa、温度为70℃下浓缩至固形物含量为1.4mg/10ml,即得甘草浓缩液,备用;
③、淡竹叶预处理:将新鲜的淡竹叶,洗净,投入占其重量2倍、体积浓度为75%的食用乙醇中,在18℃下浸泡2天,过滤,收集淡竹叶醇提液;再向淡竹叶醇提液中加入清水,使其醇度降至25%,并用浓度为12%的磷酸溶液调节其pH值至4.8,然后在5℃下静放至完全沉淀,过滤,分别收集沉淀和上清液,备用;再将备用的上清液在压力为6KPa、温度为70℃下浓缩至无醇,然后转移至冷库中,在0℃下静放至完全沉淀,过滤,收集二次沉淀;将二次沉淀与备用的沉淀合并,干燥、粉碎,即得淡竹叶粉,备用;
④、黄连预处理:将黄连洗净,投入同等重量的沸水中,煎煮40min,过滤,得水煮黄连;再将水煮黄连处理成120目的细料,并向细料中加入占其重量3倍、体积浓度为60%的食用乙醇,在常温常压下浸泡14h,过滤,收集黄连醇提液;再向黄连醇提液中加入清水,使醇度降至32%,然后在5℃下静放12h,过滤,收集上层的黄连溶液;再将黄连溶液在压力为6KPa、温度为70℃下浓缩至无醇,再加入占原黄连重量7%的麦芽糊精,搅匀,在压力为6KPa、温度为70℃下浓缩至固形物含量为2.5mg/10ml,即得黄连液,备用;
⑤、芙蓉叶预处理:将新鲜的芙蓉叶,洗净,与同等重量的热水一起处理成80目的浆汁,再经压滤,收集芙蓉叶汁液;将芙蓉叶汁液在压力为6KPa、温度为70℃下浓缩至原体积的1/3,即得芙蓉叶汁,备用;
⑥、地榆预处理:将新鲜的地榆,洗净,切成厚度为0.15-0.25cm的片状,投入占其重量3倍的沸水中,煎煮45min,过滤,收集水煮地榆,然后将水煮地榆在65℃下干燥至水分小于8.0%,得地榆片;再将地榆片经超微粉碎,过孔径为25nm的筛,即得地榆细粉,备用;
⑦、络石藤预处理:将新鲜的络石藤,洗净,投入占其重量3倍、体积浓度为75%的食用乙醇中,回流提取5h,过滤,得络石藤醇提液;再向络石藤醇提液中加入45℃的水,使其醇度降至40%,然后在45℃下过极性大孔树脂柱(型号为ADS-21树脂),上柱的流速为7L/h,再用相当于2.25个柱体积的乙酸乙酯洗脱,洗脱液的流速为4L/h,收集洗脱液;再将洗脱液在压力为6KPa、温度为48℃下浓缩至原体积的1/2,接着加入同等体积的清水,并加入占原络石藤重量2.5%的吐温60,搅匀,在压力为6KPa、温度为70℃下浓缩至木犀草素的含量为12.5mg/ml,得络石藤浓缩液,备用;
㈢、配制:
A、干粉一制备:将备用的黄连液和络石藤浓缩液混匀,经喷雾干燥,得干粉一,备用;
B、干粉二制备:将备用的甘草浓缩液、芙蓉叶汁混合,经喷雾干燥,得干粉二,备用;
C、初混合:将备用的干粉一、干粉二、淡竹叶粉、地榆细粉、丝瓜茸、茶油一起混合,经均质机反复处理3次,收集均匀的初混细粉,备用;
D、制膏:将备用的初混细粉投入备用的鲜茶花澄清液中,同时加入占初混细粉重量1%的阿拉伯树胶搅匀,经均质机反复处理3次,收集均匀的膏状物,然后将其与同等重量的凡士林或医药热熔胶加热混合均匀,即成茶花烫伤药。
实施例二:
本实施例的茶花烫伤药,是由以下重量份的原料制备而成:
鲜茶花65 茶油4 丝瓜茸10
淡竹叶5 黄连2 芙蓉叶1.5
地榆4 甘草5 络石藤2.5。
其它与实施例一相同。
实施例三:
本实施例的茶花烫伤药,是由以下重量份的原料制备而成:
鲜茶花55 茶油5 丝瓜茸15
淡竹叶8 黄连4 芙蓉叶2
地榆3 甘草3 络石藤4。
其它与实施例一相同。
本发明的茶花烫伤药,适用于治疗各种程度的烧烫伤,对刀伤和擦碰伤也有较好的治疗效果。
Claims (4)
1.一种茶花烫伤药,其特征在于是由以下重量份的原料制备而成:
鲜茶花45-65 茶油4-7 丝瓜茸10-18
淡竹叶5-10 黄连2-5 芙蓉叶1.5-3.5
地榆1-4 甘草2-5 络石藤2.5-5.5;
其制备过程如下:
㈠、备料:按照上述重量份,分别称取各原料,备用;
㈡、原料预处理:
①、鲜茶花预处理:将无虫害的新鲜茶花,放入清水中洗涤3-6次,捞出,研磨处理成60-100目的细料,然后压滤,分别收集茶花滤液和茶花滤渣,备用;再将备用的茶花滤渣与占其重量2-4倍、体积浓度为55-78%的食用乙醇在1-10℃下混合,静置处理3-5h、并每隔30min沿顺时针方向搅拌2-5min,过滤,收集醇提茶花溶液;再将醇提茶花溶液在压力为10-18KPa、温度为32-49℃下浓缩至溶液中的醇度为30-36%,得粗浓缩液;然后将粗浓缩液和备用的茶花滤液合并,搅拌30-45min,接着加入占原鲜茶花重量12-20%的红糖,再按1-2℃/min的升温速度边搅拌边加热至40-58℃,然后放置在4-10℃的环境里降至18-20℃时,过滤,收集上层溶液;再将上层溶液在压力为8-12KPa、温度为50-68℃下浓缩至无醇,得浓缩液;再向浓缩液中加入占原鲜茶花重量1.5-3.5%的茶多酚,搅拌至完全溶解,然后,经3000-5000转/min的高速离心机离心处理,收集上层澄清液,即得鲜茶花澄清液,备用;
②、甘草预处理:将新鲜、无腐烂、无虫害的甘草,洗净,与占其重量35-45%的清水处理成100-150目的浆料,然后压滤,分别收集甘草水液和甘草渣,备用;再向备用的甘草渣中加入占其重量1.2-1.85%的果胶酶、3.5-6.0%的纤维素酶、0.5-0.85%的蛋白酶,同时加入占其重量10-25%、35-40℃的水稀释,密封处理15-20h,再用150-250目的纱布过滤,收集甘草酶解滤渣;然后,将甘草酶解滤渣在常温下经均质机处理成200-300目的甘草酶解滤渣浆料,再将甘草酶解滤渣浆料和备用的甘草水液合并,在压力为5-8KPa、温度为60-78℃下浓缩至固形物含量为1.2-1.56mg/10ml,即得甘草浓缩液,备用;
③、淡竹叶预处理:将新鲜的淡竹叶,洗净,投入占其重量1-3倍、体积浓度为65-85%的食用乙醇中,在10-25℃下浸泡1-2.5天,过滤,收集淡竹叶醇提液;再向淡竹叶醇提液中加入清水,使其醇度降至20-30%,并用浓度为10-15%的无机酸溶液调节其pH值至4.5-5.0,然后在0-10℃下静放至完全沉淀,过滤,分别收集沉淀和上清液,备用;再将备用的上清液在压力为5-8KPa、温度为60-78℃下浓缩至无醇,然后转移至冷库中,在-4~4℃下静放至完全沉淀,过滤,收集二次沉淀;将二次沉淀与备用的沉淀合并,干燥、粉碎,即得淡竹叶粉,备用;
④、黄连预处理:将黄连洗净,投入同等重量的沸水中,煎煮30-45min,过滤,得水煮黄连;再将水煮黄连处理成100-160目的细料,并向细料中加入占其重量2-4倍、体积浓度为50-70%的食用乙醇,在常温常压下浸泡12-16h,过滤,收集黄连醇提液;再向黄连醇提液中加入清水,使醇度降至30-35%,然后在0-10℃下静放10-15h,过滤,收集上层的黄连溶液;再将黄连溶液在压力为5-8KPa、温度为60-78℃下浓缩至无醇,再加入占原黄连重量5.5-9.5%的麦芽糊精,搅匀,在压力为5-8KPa、温度为60-78℃下浓缩至固形物含量为1.8-3.5mg/10ml,即得黄连液,备用;
⑤、芙蓉叶预处理:将新鲜的芙蓉叶,洗净,与同等重量的热水一起处理成60-100目的浆汁,再经压滤,收集芙蓉叶汁液;将芙蓉叶汁液在压力为5-8KPa、温度为60-78℃下浓缩至原体积的1/4-1/2,即得芙蓉叶汁,备用;
⑥、地榆预处理:将新鲜的地榆,洗净,切成片状,投入占其重量2-4倍的沸水中,煎煮30-55min,过滤,收集水煮地榆,然后将水煮地榆在60-70℃下干燥至水分小于8.0%,得地榆片;再将地榆片经超微粉碎,过孔径为15-35nm的筛,即得地榆细粉,备用;
⑦、络石藤预处理:将新鲜的络石藤,洗净,投入占其重量2-4倍、体积浓度为70-80%的食用乙醇中,回流提取3.0-6.0h,过滤,得络石藤醇提液;再向络石藤醇提液中加入40-50℃的水,使其醇度降至35-45%,然后在40-50℃下过极性大孔树脂柱,上柱的流速为5-9L/h,再用相当于2-2.5个柱体积的有机溶剂洗脱,洗脱液的流速为3-5L/h,收集洗脱液;再将洗脱液在压力为5-8KPa、温度为40-55℃下浓缩至原体积的1/2,接着加入同等体积的清水,并加入占原络石藤重量1.5-3.5%的吐温60,搅匀,在压力为5-8KPa、温度为60-78℃下浓缩至木犀草素的含量为10.5-16.5mg/ml,得络石藤浓缩液,备用;
㈢、配制:
A、干粉一制备:将备用的黄连液和络石藤浓缩液混匀,经喷雾干燥,得干粉一,备用;
B、干粉二制备:将备用的甘草浓缩液、芙蓉叶汁混合,经喷雾干燥,得干粉二,备用;
C、初混合:将备用的干粉一、干粉二、淡竹叶粉、地榆细粉、丝瓜茸、茶油一起混合,经均质机反复处理2-4次,收集均匀的初混细粉,备用;
D、制膏:将备用的初混细粉投入备用的鲜茶花澄清液中,同时加入占初混细粉重量0.5-1.25%的植物胶搅匀,经均质机反复处理2-4次,收集均匀的膏状物,然后将其与同等重量的凡士林或医药热熔胶加热混合均匀,即成茶花烫伤药。
2.根据权利要求1所述的茶花烫伤药,其特征在于是由以下重量份的原料制备而成:
鲜茶花45 茶油7 丝瓜茸18
淡竹叶10 黄连5 芙蓉叶3.5
地榆1 甘草2 络石藤5.5。
3.根据权利要求1所述的茶花烫伤药,其特征在于是由以下重量份的原料制备而成:
鲜茶花65 茶油4 丝瓜茸10
淡竹叶 5 黄连2 芙蓉叶1.5
地榆 4 甘草5 络石藤2.5。
4.根据权利要求1所述的茶花烫伤药,其特征在于是由以下重量份的原料制备而成:
鲜茶花55 茶油5 丝瓜茸15
淡竹叶 8 黄连4 芙蓉叶 2
地榆 3 甘草3 络石藤 4。
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