CN104524202A - Externally applied patch for treating gastrointestinal dysfunction - Google Patents
Externally applied patch for treating gastrointestinal dysfunction Download PDFInfo
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- CN104524202A CN104524202A CN201410741032.7A CN201410741032A CN104524202A CN 104524202 A CN104524202 A CN 104524202A CN 201410741032 A CN201410741032 A CN 201410741032A CN 104524202 A CN104524202 A CN 104524202A
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
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Abstract
The invention discloses an externally applied patch, which is used for treating gastrointestinal dysfunction and is specially offered to adults. The externally applied patch comprises a medical non-woven fabric layer, a drug layer and a protective layer from inside to outside. The drug layer contains externally applied powder and glycerin. The medical non-woven fabric is uniformly smeared with the externally applied powder and glycerin and then the medical non-woven fabric is inserted into the protective layer so that the externally applied patch is prepared. The externally applied patch comprises, by weight, 10-15 parts of radix ophiopogonis, 10-15 parts of anemarrhena, 8-12 parts of hedyotis diffusa, 8-12 parts of guava leaf, 5-10 parts of banksia rose, 5-10 parts of wrinkled giant hyssop, 3-7 parts of ginseng fruit, 3-7 parts of cassia bark and 2-5 parts of dried orange peel. The externally applied patch has functions of easing pain, stopping diarrhea and stopping emesis by being applied to belly, stomach or intestines so that effects of harmonizing intestine-stomach, protecting liver and invigorating spleen, calming nerves and improving sleep quality are obtained.
Description
Technical field
The present invention relates to a kind of externally applied plaster, be specifically related to a kind of externally applied plaster for the treatment of gastrointestinal dysfunction.
Background technology
Functional gastrointestinal disorder is also known as gastrointestinal neurosis; it is the general name of one group of gastrointestinal syndrome; Nervous and Mental Factors is this pathogenetic main inducing; as the difficulty in nervous, anxiety, life and work, worry, accident misfortune etc.; all can draw and affect gastrointestinal function normal activity, and then cause gastrointestinal dysfunction.How slow gastrointestinal dysfunction onset is, clinical manifestation is based on gastrointestinal symptom, the patient of stomach neurosis shows as more: glutted after burning sensation under acid regurgitation, belch, anorexia, Nausea and vomiting, xiphoid-process, food, epigastric discomfort or pain, whenever emotion changes then exacerbation of symptoms.Intestinal neurosis, also known as irritable bowel syndrome, is the modal functional disease of gastrointestinal tract.Based on bowel symptoms, can lay one's hand on and streak swollen thing when patient often has stomachache, abdominal distention, borborygmus, diarrhoea and constipation, lower-left to suffer from abdominal pain, stomachache often increases the weight of because of feed or cold drink, alleviates after defecation, aerofluxus, coloclysis.Stomachache often with abdominal distention, defecation not freely sense or defecation frequency increase, feces such as rarely can to do at the symptom.This is claimed to be colon dysfunction, spastic colon, adaptive colitis, spastic colitis, mucus colitis, emotional diarrhea etc. in the past.
Onset is mostly slow, and the course of disease is often for years, in persistence or there is recurrent exerbation.Clinical manifestation, based on gastrointestinal symptom, can be confined to pharynx, esophagus or stomach, but the most common with bowel symptoms, also can simultaneously with other common symptons neurosal.At present, usually take the medicine auxiliary treatment such as tranquilizer, relieving spasm to stop pain medicine, as tranquilizer chlordiazepoxide, stable, chlorpromazine, phenobarbital, miltown or oryzanol can the stress of reduction of patient; Anticholinergic agents can make smooth muscle loosening as belladonna, atropine, probanthine etc., has relieving spasm to stop pain effect; Vitamin B6, chlorpromazine, promethazine, motilium etc. can be vomitted by alleviating neuropathic; Compound Diphenoxylate or 0.25% slave husband card can alleviate symptom of diarrhea.
But, usually containing antibiotic or hormone in above-mentioned Western medicine, the discomfort sensation in alleviation gastrointestinal portion that can be very fast, but cure the symptoms, not the disease, be difficult to the object reaching radical cure, also easy recurrent exerbation; And the rate of exchange of Western medicine dosage are large, also can cause certain zest injury for the oral cavity of human body, gastrointestinal mucosa, not easily take for a long time.And Chinese medicine, the property of medicine is gentle, do not have toxic and side effects, can reach the object of radical cure, but comparitive study is slow to human body; And the processing of Chinese medicine is more coarse, and mouthfeel is poor, not easily play its due drug effect, or the original effect of medicine of high temperature concentrated extract destroyed.
Summary of the invention
Technical problem to be solved by this invention is the externally applied plaster providing a kind for the treatment of gastrointestinal dysfunction of being grown up special for the deficiencies in the prior art, there is after being affixed on abdominal part, stomach or intestines effect of analgesia, antidiarrheal, preventing or arresting vomiting, not only can harmonizing intestine-stomach, protect the liver spleen invigorating, can reach calm, effect of sleeping of relaxing simultaneously.
The present invention is achieved through the following technical solutions:
First the present invention provides one to treat gastrointestinal dysfunction Dressed medicine powder, comprises the raw material of following weight portion: wheat door 10-15 part, Rhizoma Anemarrhenae 10-15 part, Herba Hedyotidis Diffusae 8-12 part, Folium Psidii Guajavae 8-12 part, Radix Aucklandiae 5-10 part, Herba Pogostemonis 5-10 part, Rhizoma Tupistrae Chinensis 3-7 part, Cortex cinnamomi japonici (Ramulus Cinnamomi) 3-7 part, Pericarpium Citri Reticulatae 2-5 part;
The preparation method of above-mentioned powder is:
(1), after pretreatment of raw material: Jiang Maimen, the Rhizoma Anemarrhenae, Herba Hedyotidis Diffusae, Folium Psidii Guajavae, the Radix Aucklandiae, Herba Pogostemonis, Rhizoma Tupistrae Chinensis, Cortex cinnamomi japonici (Ramulus Cinnamomi), Pericarpium Citri Reticulatae remove impurity and part of going mouldy, clean, dry, be broken into the fragment that length is 3 ~ 5cm respectively;
(2) weighed according to corresponding proportioning by the various Chinese medicine fragments described in step 1, often kind of Chinese medicine fragment adds the water of 50-60 times of weight respectively, decocts 3 ~ 5 times respectively, each 8 ~ 12min; Carry out coarse filtration respectively to above-mentioned each decoction liquor, liquid is successively filtered by 100 orders, 200 orders, 300 orders and 400 mesh sieve thin,tough silk successively, removes floating foreign material and leaves and takes filtrate acquisition coarse filtration liquid;
(3) merge coarse filtration liquid and carry out fine filtering: merge above-mentioned coarse filtration liquid and carry out fine filtering, be the microporous filter membrane of 0.45 μm, 0.22 μm successively by aperture, operating pressure 0.3MPa, obtains fine filtering liquid;
(4) concentrated, lyophilization: fine filtering liquid being concentrated in concentrating under reduced pressure tank relative density is 1 ± 0.01, and concentrated solution is obtained freezing powder and Dressed medicine powder by Freeze Drying Technique.
Preferably, the Freeze Drying Technique described in step 4 refers to be put in cryogenic refrigerator by concentrated solution, pre-cooling 2 ~ 3h at-30 DEG C; Then put into freeze dryer and be cooled to rapidly-30 DEG C ~-40 DEG C at 1 ~ 2h, feed liquid becomes block structure; Lump material is warming up to-10 ~ 0 DEG C in 3 ~ 5h, then in 0.5 ~ 1h, is cooled to rapidly-30 DEG C ~-40 DEG C, material becomes surface irregularity, the loose ice-like structure that there is a large amount of through hole inside; Open vacuum system, control vacuum and slowly rise, make vacuum reach 10 ~ 30Pa in 30min, holding temperature is-20 ~-15 DEG C; Open heating system, make the temperature of material slowly be warming up to 30 ~ 40 DEG C by-20 DEG C ~-15 DEG C in 2-4h, maintain this temperature 2 ~ 5h and keep vacuum 10 ~ 30Pa; Close vacuum system, make pressure slowly return to normal pressure, obtain the freeze-dried powder of material.
The present invention also provides a kind of externally applied plaster containing above-mentioned Dressed medicine powder, comprises medical non-woven layer of cloth, medicine layer and protective layer from the inside to the outside; Described medicine layer comprises Dressed medicine powder and glycerol, is applied in after on non-woven fabrics after Dressed medicine powder and glycerol mix homogeneously, then is embedded in protective layer by non-woven fabrics and be namely prepared into externally applied plaster.
Preferably, described protective layer is mackintosh, has protector, tear protector and externally applied plaster can be affixed on affected part with four limits of contact skin one side.
Preferably, described externally applied plaster, one pastes the glycerol containing 5-10g Dressed medicine powder and 5-10g.
Preferably, described externally applied plaster is external use plaster, tears protector and be bonded at abdominal part, stomach or intestines during use, and within 7 days, be 1 course for the treatment of, 2-4 can reach the object of healing the course for the treatment of.
The main distinction of the present invention and prior art is:
(1) decoct various Chinese medicine respectively in decoction process, the drug effect of various medicine uniqueness in decoction process, can not be destroyed;
(2) be affixed on abdominal part, stomach or intestines with the form of externally applied plaster, evaded the shortcoming of Chinese medicine bitter in the mouth, and any zest will be caused to injure to oral cavity, gastrointestinal;
(3) form of externally applied plaster overcome traditional plaster exist pungent abnormal smells from the patient shortcoming, be affixed on patient with it without any the taste of discomfort, and do not exist plaster be difficult to clean drawback;
(4) there is after being affixed on abdominal part, stomach or intestines effect of analgesia, antidiarrheal, preventing or arresting vomiting, not only can harmonizing intestine-stomach, protect the liver spleen invigorating, can reach calm, effect of sleeping of relaxing simultaneously; Curative effect is fast, short treating period;
(5) adopt Vacuum Freezing & Drying Technology to prepare freeze-dried powder, the moisture of material directly distils, the chemical composition keeping material original in dry run and physical property, and better preserves the active substance in raw material.
Detailed description of the invention
Below in conjunction with specific embodiment, use the present invention is described in detail.
Embodiment 1:
Treat a Dressed medicine powder for gastrointestinal dysfunction, comprise the raw material of following weight portion: 10 parts, wheat door, the Rhizoma Anemarrhenae 10 parts, Herba Hedyotidis Diffusae 8 parts, Folium Psidii Guajavae 8 parts, the Radix Aucklandiae 5 parts, Herba Pogostemonis 5 parts, Rhizoma Tupistrae Chinensis 3 parts, 3 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Pericarpium Citri Reticulatae 2 parts;
The preparation method of above-mentioned powder is:
(1), after pretreatment of raw material: Jiang Maimen, the Rhizoma Anemarrhenae, Herba Hedyotidis Diffusae, Folium Psidii Guajavae, the Radix Aucklandiae, Herba Pogostemonis, Rhizoma Tupistrae Chinensis, Cortex cinnamomi japonici (Ramulus Cinnamomi), Pericarpium Citri Reticulatae remove impurity and part of going mouldy, clean, dry, be broken into the fragment that length is 3 ~ 5cm respectively;
(2) weighed according to corresponding proportioning by the various Chinese medicine fragments described in step 1, often kind of Chinese medicine fragment adds the water of 55 times of weight respectively, decocts 4 times respectively, each 10min; Carry out coarse filtration respectively to above-mentioned each decoction liquor, liquid is successively filtered by 100 orders, 200 orders, 300 orders and 400 mesh sieve thin,tough silk successively, removes floating foreign material and leaves and takes filtrate acquisition coarse filtration liquid;
(3) merge coarse filtration liquid and carry out fine filtering: merge above-mentioned coarse filtration liquid and carry out fine filtering, be the microporous filter membrane of 0.45 μm, 0.22 μm successively by aperture, operating pressure 0.3MPa, obtains fine filtering liquid;
(4) concentrated, lyophilization: fine filtering liquid being concentrated in concentrating under reduced pressure tank relative density is 1 ± 0.01, and concentrated solution is obtained freezing powder and Dressed medicine powder by Freeze Drying Technique; Freeze Drying Technique refers to be put in cryogenic refrigerator by concentrated solution, pre-cooling 2.5h at-30 DEG C; Then put into freeze dryer and be cooled to rapidly-30 DEG C ~-40 DEG C at 1.5h, feed liquid becomes block structure; Lump material is warming up to-10 ~ 0 DEG C in 4h, then in 1h, is cooled to rapidly-30 DEG C ~-40 DEG C, material becomes surface irregularity, the loose ice-like structure that there is a large amount of through hole inside; Open vacuum system, control vacuum and slowly rise, make vacuum reach 10 ~ 30Pa in 30min, holding temperature is-20 ~-15 DEG C; Open heating system, make the temperature of material slowly be warming up to 30 ~ 40 DEG C by-20 DEG C ~-15 DEG C in 3h, maintain this temperature 4h and keep vacuum 10 ~ 30Pa; Close vacuum system, make pressure slowly return to normal pressure, obtain the freeze-dried powder of material.
The present invention also provides a kind of externally applied plaster containing above-mentioned Dressed medicine powder, comprises medical non-woven layer of cloth, medicine layer and protective layer from the inside to the outside; Described medicine layer comprises 8g Dressed medicine powder and 10g glycerol, is applied in after on non-woven fabrics after Dressed medicine powder and glycerol mix homogeneously, then is embedded in protective layer by non-woven fabrics and be namely prepared into externally applied plaster; Protective layer is mackintosh, has protector, tear protector and externally applied plaster can be affixed on affected part with four limits of contact skin one side.
Embodiment 2:
Treat a Dressed medicine powder for gastrointestinal dysfunction, comprise the raw material of following weight portion: 15 parts, wheat door, the Rhizoma Anemarrhenae 15 parts, Herba Hedyotidis Diffusae 12 parts, Folium Psidii Guajavae 12 parts, the Radix Aucklandiae 10 parts, Herba Pogostemonis 10 parts, Rhizoma Tupistrae Chinensis 7 parts, 7 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Pericarpium Citri Reticulatae 5 parts; Dressed medicine powder preparation method is identical with embodiment 1;
Externally applied plaster structure containing embodiment 2 Dressed medicine powder is identical with embodiment 1, and difference is, medicine layer comprises 5g Dressed medicine powder and 8g glycerol.
Embodiment 3:
Treat a Dressed medicine powder for gastrointestinal dysfunction, comprise the raw material of following weight portion: 13 parts, wheat door, the Rhizoma Anemarrhenae 12 parts, Herba Hedyotidis Diffusae 10 parts, Folium Psidii Guajavae 10 parts, the Radix Aucklandiae 7 parts, Herba Pogostemonis 8 parts, Rhizoma Tupistrae Chinensis 4 parts, 5 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Pericarpium Citri Reticulatae 3 parts; Dressed medicine powder preparation method is identical with embodiment 1;
Externally applied plaster structure containing embodiment 3 Dressed medicine powder is identical with embodiment 1, and difference is, medicine layer comprises 6g Dressed medicine powder and 8g glycerol.
Embodiment 4:
Zhang, female, 35 years old, Qingdao of Shandong province, in gastrointestinal neurosis in 2012, glutted after burning sensation under acid regurgitation, belch, anorexia, Nausea and vomiting, xiphoid-process, food, epigastric discomfort or pain, whenever emotion changes then exacerbation of symptoms, and with the symptom of insomnia; After using the externally applied plaster described in the embodiment of the present invention 1, after 2 courses for the treatment of, malaise symptoms is alleviated gradually, and insomnia alleviates; After pasting 2 courses for the treatment of again, malaise symptoms disappears completely, no longer has a sleepless night; Following up a case by regular visits to, there is not recurrence in patient.
Embodiment 5:
Yao, man, 55 years old, Shandong Province Huang Island people, suffered from gastrointestinal neurosis, and can lay one's hand on and streak swollen thing time stomachache in stomachache, abdominal distention, borborygmus, diarrhoea and constipation, lower-left, stomachache often increases the weight of because of feed or cold drink, and insomnia is seriously; After using the externally applied plaster described in the embodiment of the present invention 2, after 1 course for the treatment of, malaise symptoms is alleviated gradually, and insomnia alleviates; After pasting 2 courses for the treatment of again, malaise symptoms disappears completely, and no longer has a sleepless night; Following up a case by regular visits to, there is not recurrence in patient.
Embodiment 6:
Tan, man, 40 years old, people from Laizhou, Shandong Province, suffered from gastrointestinal neurosis, and paroxysmal upper abdomen burns sample pain, and often occurs diarrhoea; After using the externally applied plaster described in the embodiment of the present invention 3, after 1 course for the treatment of, malaise symptoms is alleviated gradually, and insomnia alleviates; After pasting 2 courses for the treatment of again, malaise symptoms disappears completely, and no longer has a sleepless night; Following up a case by regular visits to, there is not recurrence in patient.
Claims (7)
1. treat the Dressed medicine powder of gastrointestinal dysfunction for one kind, it is characterized in that, comprise the raw material of following weight portion: wheat door 10-15 part, Rhizoma Anemarrhenae 10-15 part, Herba Hedyotidis Diffusae 8-12 part, Folium Psidii Guajavae 8-12 part, Radix Aucklandiae 5-10 part, Herba Pogostemonis 5-10 part, Rhizoma Tupistrae Chinensis 3-7 part, Cortex cinnamomi japonici (Ramulus Cinnamomi) 3-7 part, Pericarpium Citri Reticulatae 2-5 part.
2. a preparation method for Dressed medicine powder described in claim 1, is characterized in that, comprises the following steps:
(1), after pretreatment of raw material: Jiang Maimen, the Rhizoma Anemarrhenae, Herba Hedyotidis Diffusae, Folium Psidii Guajavae, the Radix Aucklandiae, Herba Pogostemonis, Rhizoma Tupistrae Chinensis, Cortex cinnamomi japonici (Ramulus Cinnamomi), Pericarpium Citri Reticulatae remove impurity and part of going mouldy, clean, dry, be broken into the fragment that length is 3 ~ 5cm respectively;
(2) weighed according to corresponding proportioning by the various Chinese medicine fragments described in step 1, often kind of Chinese medicine fragment adds the water of 50-60 times of weight respectively, decocts 3 ~ 5 times respectively, each 8 ~ 12min; Carry out coarse filtration respectively to above-mentioned each decoction liquor, liquid is successively filtered by 100 orders, 200 orders, 300 orders and 400 mesh sieve thin,tough silk successively, removes floating foreign material and leaves and takes filtrate acquisition coarse filtration liquid;
(3) merge coarse filtration liquid and carry out fine filtering: merge above-mentioned coarse filtration liquid and carry out fine filtering, be the microporous filter membrane of 0.45 μm, 0.22 μm successively by aperture, operating pressure 0.3MPa, obtains fine filtering liquid;
(4) concentrated, lyophilization: fine filtering liquid being concentrated in concentrating under reduced pressure tank relative density is 1 ± 0.01, and concentrated solution is obtained freezing powder and Dressed medicine powder by Freeze Drying Technique.
3. preparation method according to claim 1, it is characterized in that, the Freeze Drying Technique described in step 4 refers to be put in cryogenic refrigerator by concentrated solution, pre-cooling 2 ~ 3h at-30 DEG C; Then put into freeze dryer and be cooled to rapidly-30 DEG C ~-40 DEG C at 1 ~ 2h, feed liquid becomes block structure; Lump material is warming up to-10 ~ 0 DEG C in 3 ~ 5h, then in 0.5 ~ 1h, is cooled to rapidly-30 DEG C ~-40 DEG C, material becomes surface irregularity, the loose ice-like structure that there is a large amount of through hole inside; Open vacuum system, control vacuum and slowly rise, make vacuum reach 10 ~ 30Pa in 30min, holding temperature is-20 ~-15 DEG C; Open heating system, make the temperature of material slowly be warming up to 30 ~ 40 DEG C by-20 DEG C ~-15 DEG C in 2-4h, maintain this temperature 2 ~ 5h and keep vacuum 10 ~ 30Pa; Close vacuum system, make pressure slowly return to normal pressure, obtain the freeze-dried powder of material.
4. the externally applied plaster containing Dressed medicine powder described in claim 1, is characterized in that, comprise medical non-woven layer of cloth, medicine layer and protective layer from the inside to the outside; Described medicine layer comprises Dressed medicine powder and glycerol, is applied in after on non-woven fabrics, then is embedded in protective layer by non-woven fabrics after Dressed medicine powder and glycerol mix homogeneously.
5. externally applied plaster according to claim 4, is characterized in that, described protective layer is mackintosh, has protector, tear protector and externally applied plaster can be affixed on affected part with four limits of contact skin one side.
6. externally applied plaster according to claim 4, is characterized in that, described externally applied plaster, and one pastes the glycerol containing 5-10g Dressed medicine powder and 5-10g.
7. externally applied plaster according to claim 4, is characterized in that, described externally applied plaster is external use plaster, tears protector and be bonded at abdominal part, stomach or intestines during use, and within 7 days, be 1 course for the treatment of, 2-4 can reach the object of healing the course for the treatment of.
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112587580A (en) * | 2021-02-24 | 2021-04-02 | 中国人民解放军总医院第一医学中心 | Traditional Chinese medicine composition for improving gastrointestinal dysfunction and preparation process of transdermal patch preparation thereof |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1528351A (en) * | 2003-09-30 | 2004-09-15 | 武汉健民中药工程有限责任公司 | Chinese medicine for treating irritable bowel syndrome and preparing method thereof |
CN101129537A (en) * | 2007-09-03 | 2008-02-27 | 徐恒雁 | Orally taken traditional Chinese medicine composition for treating irritable bowel syndrome |
CN102309684A (en) * | 2010-06-30 | 2012-01-11 | 孙超 | Traditional Chinese medicine prescription for treating gastrointestinal neurosis |
CN103301387A (en) * | 2013-06-25 | 2013-09-18 | 管庆军 | Traditional Chinese medicine for treating gastrointestinal disease |
-
2014
- 2014-12-07 CN CN201410741032.7A patent/CN104524202A/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1528351A (en) * | 2003-09-30 | 2004-09-15 | 武汉健民中药工程有限责任公司 | Chinese medicine for treating irritable bowel syndrome and preparing method thereof |
CN101129537A (en) * | 2007-09-03 | 2008-02-27 | 徐恒雁 | Orally taken traditional Chinese medicine composition for treating irritable bowel syndrome |
CN102309684A (en) * | 2010-06-30 | 2012-01-11 | 孙超 | Traditional Chinese medicine prescription for treating gastrointestinal neurosis |
CN103301387A (en) * | 2013-06-25 | 2013-09-18 | 管庆军 | Traditional Chinese medicine for treating gastrointestinal disease |
Non-Patent Citations (1)
Title |
---|
钟毅等: "肠激宁治疗肠易激综合征30例疗效观察", 《上海中医药杂志》 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112587580A (en) * | 2021-02-24 | 2021-04-02 | 中国人民解放军总医院第一医学中心 | Traditional Chinese medicine composition for improving gastrointestinal dysfunction and preparation process of transdermal patch preparation thereof |
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Application publication date: 20150422 |