CN104523961A - 一种治疗小儿功能性便秘的药剂 - Google Patents

一种治疗小儿功能性便秘的药剂 Download PDF

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CN104523961A
CN104523961A CN201410836754.0A CN201410836754A CN104523961A CN 104523961 A CN104523961 A CN 104523961A CN 201410836754 A CN201410836754 A CN 201410836754A CN 104523961 A CN104523961 A CN 104523961A
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孙烨
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Abstract

本发明涉及一种治疗小儿功能性便秘的药剂，它是由下列原料药制成：八角香、大叶藤、千年艾、桂花、水豆瓣、节节花、荷叶、头巾草、唇香草、菊花、热痱草、鸭儿芹、钻石风、铁马鞭、离根香、唐松草和菜子七。本发明所述的治疗小儿功能性便秘的药剂组方合理，并能调整胃肠功能，疗效显著，值得临床推广应用。

Description

一种治疗小儿功能性便秘的药剂
本发明是申请号为2014100333673、申请日为2014年1月23日、发明名称为“一种治疗小儿功能性便秘的药剂”的专利的分案申请。
技术领域
本发明涉及医药领域，具体来说涉及一种治疗小儿功能性便秘的药剂。
背景技术
便秘是指大便秘结不通，排便间隔时间延长的一种病症，是小儿的一种常见症状，患儿多表现为排便次数明显减少，常3-5天1次，且大便干燥，排便困难，可导致肛裂疼痛，使患儿惧怕排便从而加重便秘。
发明内容
本发明的目的是提供组合物在制备治疗小儿功能性便秘的药剂中的用途。
为了实现本发明的目的，本发明提供组合物在制备治疗小儿功能性便秘的药剂中的用途，所述组合物是由下列原料药按重量份计制成：八角香1-10份、大叶藤1-10份、千年艾1-10份、桂花1-10份、水豆瓣1-10份、节节花1-10份、荷叶1-10份、头巾草1-10份、唇香草1-10份、菊花1-10份、热痱草1-10份、鸭儿芹1-10份、钻石风1-10份、铁马鞭1-10份、离根香1-10份、唐松草1-10份和菜子七1-10份。
优选地，所述组合物是由下列原料药按重量份计制成：八角香9份、大叶藤8份、千年艾6份、桂花9份、水豆瓣3份、节节花8份、荷叶9份、头巾草5份、唇香草2份、菊花8份、热痱草6份、鸭儿芹7份、钻石风5份、铁马鞭8份、离根香3份、唐松草5份和菜子七2份。
更优选地，所述药剂可以是片剂、分散片、崩解片、速溶片、肠溶片、胶囊剂或汤剂。
本发明所述的治疗小儿功能性便秘的药剂组方合理，并能调整胃肠功能，疗效显著，值得临床推广应用。
具体实施方式
下面通过实施例进一步说明本发明。应该理解的是，本发明的实施例是用于说明本发明而不是对本发明的限制。根据本发明的实质对本发明进行的简单改进都属于本发明要求保护的范围。除非另有说明，否则本发明中的百分数是重量百分数。
实施例 本发明的汤剂
取八角香9克、大叶藤8克、千年艾6克、桂花9克、水豆瓣3克、节节花8克、荷叶9克、头巾草5克、唇香草2克、菊花8克、热痱草6克、鸭儿芹7克、钻石风5克、铁马鞭8克、离根香3克、唐松草5克和菜子七2克，加入水12000毫升，在装有冷凝器的烧瓶中在90℃下加热5小时，过滤，滤液即为本发明所述的汤剂。
实验例
一般资料
全部66例均为我院门诊患儿，分为2组。治疗组35例，男17例，女18例；年龄2-14岁，平均(7.54±2.41)岁；病程1个月-1年。对照组31例，男16例，女15例；年龄2-13岁，平均(7.35±2.24)岁；病程2个月-1年。2组一般资料比较差异无统计学意义(P>0.05)，具有可比性。
诊断标准
参照《实用中医儿科学》中便秘的诊断标准(江育仁，张奇文实用中医儿科学[M].2版.上海:上海科学技术出版社，2005:135,203.)。中医辨证分型参照《中医病证诊断疗效标准》(国家中医药管理局.中医病证诊断疗效标准[S].南京:南京大学出版社，1994；26.)中阴虚肠燥型，证见大便干结，状如羊屎，口干少津，舌红苔少，脉细小数。
治疗组口服实施例中制得的汤剂来进行治疗，一天两次，每次口服200毫升，连续治疗10天。
对照组口服麻仁润肠丸(北京同仁堂股份有限公司同仁堂制药厂，国药准字211020159)，每日2次，每日1丸，连续治疗10天。
疗效判定标准
治愈：1天内排便1次，便质正常，排便通畅，1个月内无复发；显效：2天内排便1次，便质趋于正常，排便通畅，1个月内无复发；有效：3天内排便1次，便质转润，排便欠畅；无效：临床症状无明显改善。
结果
经过治疗，两组的治疗结果见下表：
组别 例数 治愈 显效 有效 无效 总有效率(％)
治疗组 35 22 8 5 0 100
对照组 31 10 7 8 6 80.6
典型病例
杨某，男，5岁，于2013年1月9日来我院就诊，诊断病情为：便秘3月，大便每4-5天一次，每次排便都需要半小时以上，大便干结，痛苦异常，即使正常也感无力，面色晦暗，自感口干。住院，并口服实施例中制得的汤剂来进行治疗，一天两次，每次口服200毫升。在治疗1天后，排便1次，便质正常，自感排便通畅。继续进行治疗，共治疗10天，出院。1个月后电话随访，未复发。
关某某，男，8岁，于2013年3月15日来我院就诊，诊断病情为：便秘1月，大便每3-4天一次，大便干结，痛苦异常，自感无力口干，面色晦暗。住院，并口服实施例中制得的汤剂来进行治疗，一天两次，每次口服200毫升。在治疗1天后，排便1次，便质正常，自感排便通畅。继续进行治疗，共治疗10天，出院。1个月后电话随访，未复发。
章某某，女，9岁，于2013年8月26日来我院就诊，诊断病情为：便意少，大便每3-4天一次，有时有便意却拉不出或便量少，感觉肠道很干燥，且排便时需要很用力，痛苦异常，有时肚子会鼓鼓的。住院，并口服实施例中制得的汤剂来进行治疗，一天两次，每次口服200毫升。在治疗1天后，排便1次，便质正常，自感排便通畅。继续进行治疗，共治疗10天，出院。1个月后电话随访，未复发。

Claims (3)

1.组合物在制备治疗小儿功能性便秘的药剂中的用途，其特征在于，所述组合物是由下列原料药按重量份计制成：八角香1-10份、大叶藤1-10份、千年艾1-10份、桂花1-10份、水豆瓣1-10份、节节花1-10份、荷叶1-10份、头巾草1-10份、唇香草1-10份、菊花1-10份、热痱草1-10份、鸭儿芹1-10份、钻石风1-10份、铁马鞭1-10份、离根香1-10份、唐松草1-10份和菜子七1-10份。
2.根据权利要求1所述的用途，其特征在于，所述组合物是由下列原料药按重量份计制成：八角香9份、大叶藤8份、千年艾6份、桂花9份、水豆瓣3份、节节花8份、荷叶9份、头巾草5份、唇香草2份、菊花8份、热痱草6份、鸭儿芹7份、钻石风5份、铁马鞭8份、离根香3份、唐松草5份和菜子七2份。
3.根据权利要求1或2所述的用途，其特征在于，所述药剂可以是片剂、分散片、崩解片、速溶片、肠溶片、胶囊剂或汤剂。
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