CN104523824A - Cihang tablet preparing method - Google Patents
Cihang tablet preparing method Download PDFInfo
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- CN104523824A CN104523824A CN201510011473.6A CN201510011473A CN104523824A CN 104523824 A CN104523824 A CN 104523824A CN 201510011473 A CN201510011473 A CN 201510011473A CN 104523824 A CN104523824 A CN 104523824A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/533—Leonurus (motherwort)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The invention relates to a Cihang tablet preparing method which includes the following steps that (1) rhizoma chuanxiong is smashed into fine powder and passes a sieve with 80-120 meshes, the surface of the rhizoma chuanxiong is wetted through 70-80% ethyl alcohol, and the fine powder is closed for 0.5-2 hours and dried for 1.5-2.5 hours at the temperature of 55-65 DEG C for use; (2) angelica sinensis is smashed and broken, reflux is carried out twice with 70-80% ethyl alcohol as a solvent, 4-6 times of ethyl alcohol is added for the primary reflux for 1-2 hours, 2-4 times of ethyl alcohol is added for the secondary reflux for 1-2 hours, reflux liquid is collected twice, the ethyl alcohol is recycled, and residual liquid is concentrated to clean paste with the relative density of 1.22-1.25 at 80 DEG C; (3) water with the weight 8-12 times that of angelica sinensis alcohol extraction decoction dregs and herba leonuri is added into the angelica sinensis alcohol extraction decoction dregs and the herba leonuri so that the angelica sinensis alcohol extraction decoction dregs and the herba leonuri can be decocted for 1-3 times, each time of decoction takes 1-3 hours, decocted liquid are mixed and filtered, the filtered liquid is concentrated into clean paste with the relative density of 1.22-1.25 at 80 DEG C, pressure is reduced, the clean paste is dried to obtain dried paste, and the dried paste is smashed into fine powder, sealed and stored to be used; (4) the rhizoma chuanxiong powder, the angelica sinensis alcohol extraction clean paste and angelica sinensis decoction dregs and herba leonuri extract paste are combined to serve as active constituents, and tablets are prepared by adding pharmaceutic adjuvants.
Description
Technical field
The present invention relates to the preparation method that a kind of merciful ferry sheet is new, belong to medical art.
Technical background
Merciful ferry sheet is that after receiving cream by Herba Leonuri, Radix Angelicae Sinensis two taste medicinal material extract, add Rhizoma Chuanxiong fine powder and appropriate amount of auxiliary materials wet granulation, tabletting, film coating, to obtain final product.For removing blood stasis tissue regeneration promoting.For women's irregular menstruation ， mass in the abdomen mass in the abdomen, puerperal blood faints, lochiorrhea.In product, active ingredient ferulic acid has anticoagulant, promotes platelet disaggregation, antithrombus formation, removes vascular smooth muscular spasm, antioxidation, improves membrane stability, immunity moderation function, and the pharmacological action such as antiinflammatory, analgesia and antifertility.
It is on the low side that the existing Radix Angelicae Sinensis extracting method ferulic acid of merciful ferry sheet extracts the rate of transform, and ferulic acid extract can with the difference of temperature, acidity, placement condition, and its stability also can be variant, causes finished product content in effect duration often to occur defective problem; And containing Radix Angelicae Sinensis cream in molding formula, it is containing more oil components, and add water extraction cream amount greatly, obtained plain sheet hygroscopicity is strong, occurs the moisture absorption, reveals the exact details after causing plain coating tablets in effect duration, the problem of oil impregnate.
For solving the above-mentioned quality problems of merciful ferry sheet, improving Radix Angelicae Sinensis medical material ferulic acid and extracting the rate of transform.The invention provides the preparation method that a kind of merciful ferry sheet is new: adopted by Radix Angelicae Sinensis medical material technique of backflow to extract the rate of transform to improve ferulic acid, Herba Leonuri and Radix Angelicae Sinensis medicinal residues herbal decoction carry out drying under reduced pressure, and introduce anti-blushing agent in molding, and gelatine size effectively reduces granule and draws moist, obtained steady quality Reliable Products.
Summary of the invention
The object of the invention is to provide a kind of preparation method of merciful ferry sheet, and object is that improving ferulic acid extracts the rate of transform, and solves the preparation method of the merciful ferry sheet moisture absorption, oil impregnate, problem of revealing the exact details.
The invention provides a kind of preparation method of merciful ferry sheet, it is characterized in that, step is as follows:
Herba Leonuri: 300g
Radix Angelicae Sinensis: 200g
Rhizoma Chuanxiong: 150g
Step 1, Rhizoma Chuanxiong power are broken into fine powder, cross 100 mesh sieves, with 75% ethanol wetted surface, airtight 1 hour, dry 2 hours in 60 DEG C, for subsequent use;
Step 2, Radix Angelicae Sinensis are given as one thinks fit cataclasm, reflux 2 times with 70-80% ethanol as solvent, first time adds 5 times amount 80% alcohol reflux 1.5 hours, second time adds 3 times amount 70-80% alcohol reflux 1.5 hours, collect twice backflow, reclaim ethanol, remaining liquid is concentrated into the clear paste that relative density is 1.22-1.25 (80 DEG C);
Step 3, Radix Angelicae Sinensis alcohol extraction medicinal residues and Herba Leonuri add 10 times amount soak by water 2 times, each 2 hours, collecting decoction, and filter, filtrate is concentrated into the clear paste that relative density is 1.22-1.25 (80 DEG C), and drying under reduced pressure, gets dry extract; Dried cream powder is broken into fine powder, airtight preservation, for subsequent use.
Step 4, above-mentioned Rhizoma Chuanxiong power, Radix Angelicae Sinensis alcohol extraction Cheongju cream, the active component as merciful ferry sheet of the present invention combined by the extraction extractum of Radix Angelicae Sinensis medicinal residues and Herba Leonuri, and pharmaceutic adjuvant is prepared into tablet in addition.
Wherein pharmaceutic adjuvant comprises: anti-blushing agent: 3%-5%, filler: 2%-3%, gelatin: 1-2%, fluidizer: 0.5%.Further, method for preparing tablet thereof of the present invention, is characterized in that, preparation method is as follows:
Rhizoma Chuanxiong power, the extraction extractum of Radix Angelicae Sinensis medicinal residues and Herba Leonuri, anti-blushing agent, filler are poured trough type mixing machine into and are dry mixed 15 minutes, obtain and are dry mixed powder; Radix Angelicae Sinensis alcohol extraction Cheongju cream is poured into slowly and is dry mixed powder, wet mixing 3 minutes, add appropriate amounts of gelatin slurry depending on soft material situation, obtained suitable soft material; Soft material is put oscillating granulator and cross 18 eye mesh screens, obtained wet granular; Filled rustless steel pallet and constant temperature oven dried particles moisture to 5-6%, take out dry granule and put oscillating granulator and cross 18 eye mesh screen granulate, obtain dry granule; Get dry granule add fluidizer put trough type mixing machine stir 5-8min, by granule pack, censorship, for subsequent use; Pressed by granule specification to be 0.26g/s sheet, control plain sheet hardness >=5kg, friability≤1%, film coating, obtain 1000 special merciful ferry sheets of glad youngster, pressing plate, to obtain final product.
The present invention extracts the rate of transform for improving Radix Angelicae Sinensis medical material ferulic acid, the solution merciful ferry sheet moisture absorption, oil impregnate, the problem of revealing the exact details.Now adopt different extraction route screening Radix Angelicae Sinensis extracting method, and by Herba Leonuri and medicinal residues compound are prepared into dry cream, to increase adjuvant space, introduce anti-blushing agent simultaneously, molding formula is optimized.Gained sample is investigated through stability test, proves that this invention has advanced person, reasonable, excellent characteristic.Screening process is as follows:
Radix Angelicae Sinensis extracting method screens: adopt and carry out extracting method in water extraction, circumfluence method, infusion process, percolation four with batch Radix Angelicae Sinensis medical material (ferulaic acid content is 0.051%), and circumfluence method, infusion process, percolation all with 80% ethanol for solvent, use amount is medical material 8 times amount; Water extraction is using drinking water as solvent, and use amount is medical material 14 times amount; Performance assessment criteria extracts rate of transform soprano for optimum extracting method with ferulic acid.Concrete performance is in table 1:
Table 1 Radix Angelicae Sinensis extracts route screening
Result shows: extract rate of transform height person for performance assessment criteria with ferulic acid: circumfluence method > percolation > infusion process > water extraction.Therefore, embodiment 2 alcohol heat reflux method is best Radix Angelicae Sinensis extracting method.
Tablet forming method screens: introduce anti-blushing agent in molding formula, and Herba Leonuri and medicinal residues water extraction cream are made dry cream, and former method gained sample contrasts, and qualified samples is carried out acceleration for stabilization investigation, qualified in performance assessment criteria with accelerated test 6 months sample qualities, to determine molding method route.Concrete condition is in table 2, table 3.
Table 2 forming method embodiment
Can table 3 embodiment gained sample detection result and soft material molding
Experiment 1 be former method pilot sample, and testing 2,3,4 is new method pilot sample, and molding can show according to result and soft material, testing 4 samples is preferred plan, empirically 4 can carry out repeatability investigation.
The special merciful ferry sheet of glad youngster that existing treating excess syndrome tests 1, experiment 4 and market are bought carries out Accelerated stability test investigation, and find the present invention compared to the prior art, stability is more excellent, and data are in table 4.
It is as follows that table 4 laboratory sample and outsourcing finished product accelerated stability investigate correction data:
Investigate result according to 6 months accelerated stabilities to show: the present invention tests 4 and not only increases the Radix Angelicae Sinensis medical material ferulic acid extraction rate of transform, it is qualified to ensure in finished product content effect duration, and to have evaded in merciful ferry sheet finished product effect duration the easy moisture absorption, revealed the exact details, the problem of oil impregnate, effectively improve this product quality.
Detailed description of the invention
It is as follows that the present invention screens extracting method used:
Embodiment 1
Herba Leonuri: 300g Radix Angelicae Sinensis: 200g Rhizoma Chuanxiong: 150g
1, above three tastes, Rhizoma Chuanxiong power is broken into fine powder, crosses 100 mesh sieves, with 75% ethanol wetted surface, airtight 1 hour, dries 2 hours in 60 DEG C, for subsequent use;
2, Radix Angelicae Sinensis is given as one thinks fit cataclasm, adds 10 times amount soak by water 2 times, 2 hours first times, second time 1 hour, and collecting decoction filters, is concentrated into the clear paste that relative density is 1.22-1.25 (80 DEG C), receives cream.
3, medicinal residues and Herba Leonuri add 10 times amount soak by water 2 times, each 2 hours, collecting decoction, and filter, filtrate is concentrated into the clear paste that relative density is 1.22-1.25 (80 DEG C), and drying under reduced pressure, gets dry extract; Dried cream powder is broken into fine powder, airtight preservation, for subsequent use.
Embodiment 2
Herba Leonuri: 300g Radix Angelicae Sinensis: 200g Rhizoma Chuanxiong: 150g
1, above three tastes, Rhizoma Chuanxiong power is broken into fine powder, crosses 100 mesh sieves, with 75% ethanol wetted surface, airtight 1 hour, dries 2 hours in 60 DEG C, for subsequent use;
2, Radix Angelicae Sinensis is given as one thinks fit cataclasm, refluxes 2 times with 80% ethanol as solvent, and first time adds 5 times amount 80% ethanol 1.5 hours, second time adds 3 times amount 80% ethanol 1.5 hours, collect the percolate of 6 times of medical material amounts, reclaim ethanol, be concentrated into the clear paste that relative density is 1.22-1.25 (80 DEG C);
3, medicinal residues and Herba Leonuri add 10 times amount soak by water 2 times, each 2 hours, collecting decoction, and filter, filtrate is concentrated into the clear paste that relative density is 1.22-1.25 (80 DEG C), and drying under reduced pressure, gets dry extract; Dried cream powder is broken into fine powder, airtight preservation, for subsequent use.
Embodiment 3
Herba Leonuri: 300g Radix Angelicae Sinensis: 200g Rhizoma Chuanxiong: 150g
1, above three tastes, Rhizoma Chuanxiong power is broken into fine powder, crosses 100 mesh sieves, with 75% ethanol wetted surface, airtight 1 hour, dries 2 hours in 60 DEG C, for subsequent use;
2, Radix Angelicae Sinensis is given as one thinks fit cataclasm, adds 8 times amount 80% alcohol dipping 24 hours, decompression recycling ethanol, is concentrated into the clear paste that relative density is 1.22-1.25 (80 DEG C), receives cream.
3, medicinal residues and Herba Leonuri add 10 times amount soak by water 2 times, each 2 hours, collecting decoction, and filter, filtrate is concentrated into the clear paste that relative density is 1.22-1.25 (80 DEG C), and drying under reduced pressure, gets dry extract; Dried cream powder is broken into fine powder, airtight preservation, for subsequent use.
Embodiment 4
Herba Leonuri: 300g Radix Angelicae Sinensis: 200g Rhizoma Chuanxiong: 150g
1, above three tastes, Rhizoma Chuanxiong power is broken into fine powder, crosses 100 mesh sieves, with 75% ethanol wetted surface, airtight 1 hour, dries 2 hours in 60 DEG C, for subsequent use;
2, Radix Angelicae Sinensis is given as one thinks fit cataclasm, adds 1 times amount 80% ethanol moistening 2 hours, with the diafiltration of 3mL/min/kg speed, collects 15 times amount percolates, decompression recycling ethanol, be concentrated into the clear paste that relative density is 1.22-1.25 (80 DEG C), receives cream.
3, medicinal residues and Herba Leonuri add 10 times amount soak by water 2 times, each 2 hours, collecting decoction, and filter, filtrate is concentrated into the clear paste that relative density is 1.22-1.25 (80 DEG C), and drying under reduced pressure, gets dry extract; Dried cream powder is broken into fine powder, airtight preservation, for subsequent use.
Experimental result shows, embodiment 2 best results.
Extractum embodiment 2 prepared further and medicated powder mixing are prepared into tablet as active constituents of medicine.
Experiment 1
Herba Leonuri: 300g Radix Angelicae Sinensis: 200g Rhizoma Chuanxiong: 150g
1, above three tastes, Rhizoma Chuanxiong power is broken into fine powder, crosses 100 mesh sieves, with 75% ethanol wetted surface, airtight 1 hour, dries 2 hours in 60 DEG C, for subsequent use;
2, Radix Angelicae Sinensis is given as one thinks fit cataclasm, refluxes 2 times with 80% ethanol as solvent, and first time adds 5 times amount 80% ethanol 1.5 hours, second time adds 3 times amount 80% ethanol 1.5 hours, collect the percolate of 6 times of medical material amounts, reclaim ethanol, be concentrated into the clear paste that relative density is 1.22-1.25 (80 DEG C);
3, medicinal residues and Herba Leonuri add 10 times amount soak by water 2 times, each 2 hours, collecting decoction, and filter, filtrate is concentrated into the clear paste that relative density is 1.22-1.25 (80 DEG C), and drying under reduced pressure, gets dry extract; Dried cream powder is broken into fine powder, airtight preservation, for subsequent use.
Rhizoma Chuanxiong power: 150g Radix Angelicae Sinensis backflow cream: 86g clear paste: 106g
Starch: 20g magnesium stearate: 1.3g
3, get recipe quantity Rhizoma Chuanxiong power, starch pours trough type mixing machine into and be dry mixed 15 minutes, be obtainedly dry mixed powder;
4, refluxed by Radix Angelicae Sinensis cream, clear paste is slowly poured into and is dry mixed powder, wet mixing 3-5 minute, obtained soft material;
6, soft material is put oscillating granulator and cross 18 eye mesh screens, obtained wet granular; Filled rustless steel pallet and constant temperature oven dried particles moisture to 5-6%, take out dry granule and put oscillating granulator and cross 18 eye mesh screen granulate, obtain dry granule;
7, get dry granule add fluidizer put trough type mixing machine stir 5-8min, by granule pack, censorship, for subsequent use;
8, pressed by granule specification to be 0.26g/s sheet, control plain sheet hardness >=5kg, friability≤1%, film coating, obtain 1000 special merciful ferry sheets of glad youngster, pressing plate, to obtain final product.
Experiment 2
Herba Leonuri: 300g Radix Angelicae Sinensis: 200g Rhizoma Chuanxiong: 150g
1, above three tastes, Rhizoma Chuanxiong power is broken into fine powder, crosses 100 mesh sieves, with 75% ethanol wetted surface, airtight 1 hour, dries 2 hours in 60 DEG C, for subsequent use;
2, Radix Angelicae Sinensis is given as one thinks fit cataclasm, refluxes 2 times with 80% ethanol as solvent, and first time adds 5 times amount 80% ethanol 1.5 hours, second time adds 3 times amount 80% ethanol 1.5 hours, collect the percolate of 6 times of medical material amounts, reclaim ethanol, be concentrated into the clear paste that relative density is 1.22-1.25 (80 DEG C);
3, medicinal residues and Herba Leonuri add 10 times amount soak by water 2 times, each 2 hours, collecting decoction, and filter, filtrate is concentrated into the clear paste that relative density is 1.22-1.25 (80 DEG C), and drying under reduced pressure, gets dry extract; Dried cream powder is broken into fine powder, airtight preservation, for subsequent use.
Rhizoma Chuanxiong power: 150g Radix Angelicae Sinensis backflow cream: 86g clear paste: 106g
Starch: 7g calcium hydrogen phosphate: 13g magnesium stearate: 1.3g
4, get recipe quantity Rhizoma Chuanxiong power, starch, calcium hydrogen phosphate pour trough type mixing machine into and be dry mixed 15 minutes, be obtainedly dry mixed powder;
5, refluxed by Radix Angelicae Sinensis cream, clear paste is slowly poured into and is dry mixed powder, wet mixing 3-5 minute, obtained soft material;
6, soft material is put oscillating granulator and cross 18 eye mesh screens, obtained wet granular; Filled rustless steel pallet and constant temperature oven dried particles moisture to 5-6%, take out dry granule and put oscillating granulator and cross 18 eye mesh screen granulate, obtain dry granule;
7, get dry granule add fluidizer put trough type mixing machine stir 5-8min, by granule pack, censorship, for subsequent use;
8, pressed by granule specification to be 0.26g/s sheet, control plain sheet hardness >=5kg, friability≤1%, film coating, obtain 1000 special merciful ferry sheets of glad youngster, pressing plate, to obtain final product.
Experiment 3
Herba Leonuri: 300g Radix Angelicae Sinensis: 200g Rhizoma Chuanxiong: 150g
1, above three tastes, Rhizoma Chuanxiong power is broken into fine powder, crosses 100 mesh sieves, with 75% ethanol wetted surface, airtight 1 hour, dries 2 hours in 60 DEG C, for subsequent use;
2, Radix Angelicae Sinensis is given as one thinks fit cataclasm, refluxes 2 times with 80% ethanol as solvent, and first time adds 5 times amount 80% ethanol 1.5 hours, second time adds 3 times amount 80% ethanol 1.5 hours, collect the percolate of 6 times of medical material amounts, reclaim ethanol, be concentrated into the clear paste that relative density is 1.22-1.25 (80 DEG C);
3, medicinal residues and Herba Leonuri add 10 times amount soak by water 2 times, each 2 hours, collecting decoction, and filter, filtrate is concentrated into the clear paste that relative density is 1.22-1.25 (80 DEG C), and drying under reduced pressure, gets dry extract; Dried cream powder is broken into fine powder, airtight preservation, for subsequent use.
Rhizoma Chuanxiong power: 150g Radix Angelicae Sinensis backflow cream: 86g dried cream powder: 48g
Starch: 5g micropowder silica gel: 13g gelatine size: 20g
Magnesium stearate: 1.3g
4, get appropriate amounts of gelatin, add 10 times amount purified water and infiltrate, be heated to dissolve completely, obtained gelatine size;
5, get recipe quantity Rhizoma Chuanxiong power, dried cream powder, calcium hydrogen phosphate pour trough type mixing machine into and be dry mixed 15 minutes, be obtainedly dry mixed powder;
6, the cream that refluxed by Radix Angelicae Sinensis is slowly poured into and is dry mixed powder, and wet mixing 3 minutes, adds 20g gelatine size depending on soft material situation, obtained suitable soft material;
7, soft material is put oscillating granulator and cross 18 eye mesh screens, obtained wet granular; Filled rustless steel pallet and constant temperature oven dried particles moisture to 5-6%, take out dry granule and put oscillating granulator and cross 18 eye mesh screen granulate, obtain dry granule;
8, get dry granule add fluidizer put trough type mixing machine stir 5min, by granule pack, censorship, for subsequent use;
9, pressed by granule specification to be 0.26g/s sheet, control plain sheet hardness >=5kg, friability≤1%, film coating, obtain 1000 special merciful ferry sheets of glad youngster, pressing plate, to obtain final product.
Experiment 4
Herba Leonuri: 300g Radix Angelicae Sinensis: 200g Rhizoma Chuanxiong: 150g
1, above three tastes, Rhizoma Chuanxiong power is broken into fine powder, crosses 100 mesh sieves, with 75% ethanol wetted surface, airtight 1 hour, dries 2 hours in 60 DEG C, for subsequent use;
2, Radix Angelicae Sinensis is given as one thinks fit cataclasm, refluxes 2 times with 80% ethanol as solvent, and first time adds 5 times amount 80% ethanol 1.5 hours, second time adds 3 times amount 80% ethanol 1.5 hours, collect the percolate of 6 times of medical material amounts, reclaim ethanol, be concentrated into the clear paste that relative density is 1.22-1.25 (80 DEG C);
3, medicinal residues and Herba Leonuri add 10 times amount soak by water 2 times, each 2 hours, collecting decoction, and filter, filtrate is concentrated into the clear paste that relative density is 1.22-1.25 (80 DEG C), and drying under reduced pressure, gets dry extract; Dried cream powder is broken into fine powder, airtight preservation, for subsequent use.
Rhizoma Chuanxiong power: 150g Radix Angelicae Sinensis backflow cream: 86g dried cream powder: 48g
Starch: 5g calcium hydrogen phosphate: 13g gelatine size: 20g
Magnesium stearate: 1.3g
4, get appropriate amounts of gelatin, add 10 times amount purified water and infiltrate, be heated to dissolve completely, obtained gelatine size;
5, get recipe quantity Rhizoma Chuanxiong power, starch, dried cream powder, calcium hydrogen phosphate pour trough type mixing machine into and be dry mixed 15 minutes, be obtainedly dry mixed powder;
6, the cream that refluxed by Radix Angelicae Sinensis is slowly poured into and is dry mixed powder, and wet mixing 3 minutes, adds 20g gelatine size depending on soft material situation, obtained suitable soft material;
7, soft material is put oscillating granulator and cross 18 eye mesh screens, obtained wet granular; Filled rustless steel pallet and constant temperature oven dried particles moisture to 5-6%, take out dry granule and put oscillating granulator and cross 18 eye mesh screen granulate, obtain dry granule;
8, get dry granule add fluidizer put trough type mixing machine stir 5min, by granule pack, censorship, for subsequent use;
9, pressed by granule specification to be 0.26g/s sheet, control plain sheet hardness >=5kg, friability≤1%, film coating, obtain 1000 special merciful ferry sheets of glad youngster, pressing plate, to obtain final product.
Prove through experiment, the best results of experiment 4.
Claims (4)
1. a preparation method for merciful ferry sheet, is characterized in that, step is as follows:
Herba Leonuri: 300g
Radix Angelicae Sinensis: 200g
Rhizoma Chuanxiong: 150g
Step 1, Rhizoma Chuanxiong power are broken into fine powder, cross 80-120 mesh sieve, and with 70-80% ethanol wetted surface, airtight 0.5-2 hour, dries 1.5-2.5 hour in 55-65 DEG C, for subsequent use;
Step 2, Radix Angelicae Sinensis are given as one thinks fit cataclasm, reflux 2 times with 70-80% ethanol as solvent, first time adds 4-6 times amount alcohol reflux 1-2 hour, second time adds 2-4 times amount alcohol reflux 1-2 hour, collect twice backflow, reclaim ethanol, remaining liquid is concentrated into the clear paste that relative density is 1.22-1.25 (80 DEG C);
Step 3, Radix Angelicae Sinensis alcohol extraction medicinal residues and Herba Leonuri add soak by water 1-3 time of 8-12 times of weight, each 1-3 hour, collecting decoction, and filter, filtrate is concentrated into the clear paste that relative density is 1.22-1.25 (80 DEG C), and drying under reduced pressure, gets dry extract; Dried cream powder is broken into fine powder, airtight preservation, for subsequent use;
Step 4, above-mentioned Rhizoma Chuanxiong power, Radix Angelicae Sinensis alcohol extraction Cheongju cream, the extraction extractum of Radix Angelicae Sinensis medicinal residues and Herba Leonuri is combined as active component, adds pharmaceutic adjuvant and is prepared into tablet.
2. preparation method according to claim 1, is characterized in that,
Herba Leonuri: 300g
Radix Angelicae Sinensis: 200g
Rhizoma Chuanxiong: 150g
Step 1, Rhizoma Chuanxiong power are broken into fine powder, cross 100 mesh sieves, with 75% ethanol wetted surface, airtight 1 hour, dry 2 hours in 60 DEG C, for subsequent use;
Step 2, Radix Angelicae Sinensis are given as one thinks fit cataclasm, reflux 2 times with 70-80% ethanol as solvent, first time adds 5 times amount 80% alcohol reflux 1.5 hours, second time adds 3 times amount 70-80% alcohol reflux 1.5 hours, collect twice backflow, reclaim ethanol, remaining liquid is concentrated into the clear paste that relative density is 1.22-1.25 (80 DEG C);
Step 3, Radix Angelicae Sinensis alcohol extraction medicinal residues and Herba Leonuri add 10 times amount soak by water 2 times, each 2 hours, collecting decoction, and filter, filtrate is concentrated into the clear paste that relative density is 1.22-1.25 (80 DEG C), and drying under reduced pressure, gets dry extract; Dried cream powder is broken into fine powder, airtight preservation, for subsequent use.
Step 4, above-mentioned Rhizoma Chuanxiong power, Radix Angelicae Sinensis alcohol extraction Cheongju cream, the active component as merciful ferry sheet of the present invention combined by the extraction extractum of Radix Angelicae Sinensis medicinal residues and Herba Leonuri, and pharmaceutic adjuvant is prepared into tablet in addition.
3. preparation method according to claim 1, is characterized in that, adjuvant comprises: anti-blushing agent: 3%-5%, filler: 2%-3%, gelatin: 1-2%, fluidizer: 0.5%.
4. preparation method according to claim 3, is characterized in that, preparation method is as follows:
Rhizoma Chuanxiong power, the extraction extractum of Radix Angelicae Sinensis medicinal residues and Herba Leonuri, anti-blushing agent, filler are poured trough type mixing machine into and are dry mixed 15 minutes, obtain and are dry mixed powder; Radix Angelicae Sinensis alcohol extraction Cheongju cream is poured into slowly and is dry mixed powder, wet mixing 3 minutes, add appropriate amounts of gelatin slurry depending on soft material situation, obtained suitable soft material; Soft material is put oscillating granulator and cross 18 eye mesh screens, obtained wet granular; Filled rustless steel pallet and constant temperature oven dried particles moisture to 5-6%, take out dry granule and put oscillating granulator and cross 18 eye mesh screen granulate, obtain dry granule; Get dry granule add fluidizer put trough type mixing machine stir 5-8min, by granule pack, censorship, for subsequent use; Pressed by granule specification to be 0.26g/s sheet, control plain sheet hardness >=5kg, friability≤1%, film coating, obtain 1000 special merciful ferry sheets of glad youngster, pressing plate, to obtain final product.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107308207A (en) * | 2017-07-03 | 2017-11-03 | 广西大海阳光药业有限公司 | It is a kind of that there is promoting blood circulation, preparation of new effect and preparation method thereof is given birth to by the stasis of blood |
| CN110946897A (en) * | 2019-12-21 | 2020-04-03 | 江西九华药业有限公司 | Cihang tablet and preparation method thereof |
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| CN102335229A (en) * | 2011-09-26 | 2012-02-01 | 江西济民可信药业有限公司 | Preparation method of gynecological inflammation clearing vaginal effervescent tablet |
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| CN102335229A (en) * | 2011-09-26 | 2012-02-01 | 江西济民可信药业有限公司 | Preparation method of gynecological inflammation clearing vaginal effervescent tablet |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107308207A (en) * | 2017-07-03 | 2017-11-03 | 广西大海阳光药业有限公司 | It is a kind of that there is promoting blood circulation, preparation of new effect and preparation method thereof is given birth to by the stasis of blood |
| CN110946897A (en) * | 2019-12-21 | 2020-04-03 | 江西九华药业有限公司 | Cihang tablet and preparation method thereof |
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Address after: 336000 Yuanzhou pharmaceutical industry park, Jiangxi, Yichun Co-patentee after: Jiangxi Jinshuibao Pharmaceutical Co.,Ltd. Patentee after: JIANGXI JIMINKEXIN PHARMACEUTICAL Co.,Ltd. Address before: 336000 Yuanzhou pharmaceutical industry park, Jiangxi, Yichun Co-patentee before: JIANGXI JIMINKEXIN JINSHUIBAO PHARMACEUTICAL Co.,Ltd. Patentee before: JIANGXI JIMINKEXIN PHARMACEUTICAL Co.,Ltd. |
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