CN104508494B - Automatic analysing apparatus - Google Patents
Automatic analysing apparatus Download PDFInfo
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- CN104508494B CN104508494B CN201380039214.3A CN201380039214A CN104508494B CN 104508494 B CN104508494 B CN 104508494B CN 201380039214 A CN201380039214 A CN 201380039214A CN 104508494 B CN104508494 B CN 104508494B
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- sample
- sample probe
- probe
- runner
- cleaning
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1004—Cleaning sample transfer devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
- G01N35/1016—Control of the volume dispensed or introduced
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
- G01N35/1016—Control of the volume dispensed or introduced
- G01N2035/1018—Detecting inhomogeneities, e.g. foam, bubbles, clots
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- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The present invention provides a kind of automatic analysing apparatus, and whether the runner that it judges to include sample probe with not being capable of the fluidity of test sample or viscous effects when attracting sample with stable dispensing precision dispenses sample in the state that can stably attract.In sample attraction, before sample is attracted, in the runner including sample probe, the state that can attract the state of sample or can not attract in the case of the state for being judged as attracting, carries out the cleaning of runner.By before sample is attracted implement include sample probe runner judgement, can not by fluidity, viscous effects repeatedly implement reliability improve dispensing action.
Description
Technical field
The present invention relates to the sample dispenser of the dispensing liquor sample such as blood or urine and use the sample dispenser
Automatic analysing apparatus, more particularly to can accurately detect attraction, the automatic analysing apparatus of the blocking of drain sample probe.
Background technology
For example, in the automatic analysing apparatus such as biochemistry automatic analysing apparatus or immune automatic analysing apparatus, possess certainly
The sample dispenser that liquor sample is attracted, discharges and (hereinafter referred to as dispense) by dynamic ground from sample container to reaction vessel.
Sample dispenser possesses sample probe, the dispensing syringe for being connected to sample probe, is moved to sample probe
The mechanism of assigned position, by the front end insertion sample of sample probe, by driving dispensing syringe with ormal weight, attract regulation
The sample of amount, afterwards, sample probe is moved to reaction vessel, and discharges the sample of attraction, this dispensing action is repeated.
By the way, in the detection physical examination such as biochemical analysis is looked into, blood cell, serum, blood plasma are generally used as sample, when
When these Zi placing for a long time after taking to inspection, the solid contents (hereinafter referred to as grumeleuse) such as fibrin are produced in the sample.When
When the sample is put into automatic analysing apparatus as former state, that caused grumeleuse blocks sample probe be present.When such produce is blocked up
When filling in sample probe, the sample of ormal weight can not be dispensed into reaction vessel, correct analysis result can not be obtained.Such case
Significantly damage the analysis reliability of automatic analysing apparatus.
As the method for solving this undesirable condition, it is proposed that multiple that pressure is set in the dispensing runner including sample probe
Force snesor, the scheme of the method for the blocking of sample probe is detected according to pressure oscillation.In patent document 1, it is conceived to pressure
Variation waveform carries out the value of second differential, by compared with threshold value, being detected to the value without sticky influence
Attract abnormal.In addition, in patent document 2, obtain after release is attracted, be conceived to the residual voltage for residuing in minus side, inciting somebody to action
In the case that it is low compared with threshold value, it is judged as the structure blocked.In addition, in patent document 3, disclose based on to pressure
Area value obtained from the output of force snesor is integrated and the comparison of predetermined a reference value, judge exception during sample dispensing
Technology.In addition, in patent document 4, the detection unit for the blocking for possessing detection sample nozzle is disclosed, is blocked up producing severe
In the case of plug, stop sample analysis action.
Prior art literature
Patent document
Patent document 1：Japanese Unexamined Patent Publication 7-198726 publications
Patent document 2：Japanese Unexamined Patent Publication 11-83868 publications
Patent document 3：Japanese Unexamined Patent Publication 2000-39440 publications
Patent document 4：Japanese Unexamined Patent Publication 6-109745 publications
The content of the invention
Invent problem to be solved
When by sample probe and using syringe is being dispensed, attracting the high sample of the viscosity such as blood cell, using in attraction and
The judgement of the blocking of pressure sensor after attraction has difficulties.It is glycerol liquor when the viscosity of blood cell is, for example, the viscosity of glycerine
The viscosity of solution 60%~100%, in the case where attracting the high sample of viscosity, viscosity is higher, and sample is visited after attracting from sample
Pin returns to atmospheric pressure to the pressure between pressure sensor needs the time.It is expected to set the stand-by period after attracting in large quantities, but lead
Cause disposal ability to decline, be unpractical.
Also it can carry out that there is abundant processing in the threshold value for being judged as blocking, but in the high sample of attraction viscosity, nothing
By whether being normally to attract, all assume to be judged as there is a situation where to block.
In addition, in the high sample of dispensing viscosity, the selection for the confirmation for not implementing to block also be present, but continuously attracting
The high sample of discharge viscosity, and make sample in the scope of the rotational trajectory of sample probe in the case of generation blocking in its way
Disperse.When in the reaction vessel that the sample to disperse immerses original not predetermined discharge, then lose as automatic analysing apparatus
Reliably.
In addition, in the technology of patent document 4, in the case where producing the blocking of severe, stop sample analysis action.By
In needing once to remove the blocking, therefore continuous dispensing action can not be carried out.
It is an object of the invention to provide being removed by the blocking confirmed before sample attracts in sample probe, blocked
Cleaning action is removed, in the sample of high viscosity, can also maintain the automatic analysing apparatus of stable dispensing precision.
For solving the method for problem
For realizing that the structure of the invention of above-mentioned purpose is as follows.
A kind of automatic analysing apparatus, have liquor sample dispensing mechanism, the liquor sample dispensing mechanism include sample probe,
Said sample probe is set to attract the syringe of discharge liquor sample, connect said sample probe and the dispensing stream of said syringe
Road, supply cleaning fluid into the runner with being connected in sample probe from above-mentioned dispensing runner and sample probe inside is cleaned
Cleaning solution supplying unit, the above-mentioned cleaning solution supplying unit of connection and said syringe cleaning fluid runner and to above-mentioned clear
The magnetic valve that washing lotion runner is opened and closed, before liquor sample is attracted, diagnosis includes the state of the flow passage system in sample probe,
According to the diagnostic result of flow passage system, judgement is to attract the state of liquor sample, or in the shape that can not attract liquor sample
The state for needing runner to clean under state.
In the case of blocking is produced, also cleaning action can be removed by blocking, always can be before sample attraction
Attracted in the state of blocking in removing sample probe.
In addition, by implementing the cleaning action after sample attraction, carry out attracting preceding diagnosis before sample attraction every time, can be
Implement to block the cleaning action removed before completely plugged.Accordingly, it is capable to realize stable dispensing action.Invention effect
According to the present invention, due to the always blocking in no sample probe or the state being removed before sample attraction, because
This can not the viscous effects of test sample and it is continuous and stably implement dispensing.
In addition, by implementing the condition diagnosing in sample probe before every circulation sample attracts, blocked as needed
Cleaning action is removed, can prevent from blocking in advance, realizes the dispensing action of stable sample.Accordingly, it is capable to suppress as caused by blocking
The decline of precision is dispensed, realizes that the reliability of dispensing precision improves.
Brief description of the drawings
Fig. 1 is the skeleton diagram of automatic analysis apparatus of the present invention.
Fig. 2 is block measuring flow chart.
Fig. 3 is that cleaning method is schemed in detail.
Fig. 4 A are the variation diagrams by the negative pressure peak that the chocking-up degree of nozzle determines and residual voltage value.
Fig. 4 B are the variation diagrams of the residual voltage value after syringe Air attracts.
Fig. 4 C are the variation diagrams of the residual voltage value after syringe Air attracts.
Fig. 5 is the automatic analysing apparatus outline overall diagram of two sample probes.
Embodiment
Below, using brief description of the drawings embodiments of the invention.
Fig. 1 is the skeleton diagram of the automatic analysing apparatus of embodiments of the invention.Therefore the function in each portion is, it is known that, omit detailed
Thin narration.Reaction vessel 2 is circumferentially arranged in reaction tray 1.In reagent disc 9, multiple reagent bottles 10 can be circumferentially loaded.
The Sample transportation mechanism 17 for moving the frame 16 for having loaded sample container 15 is set near reaction tray 1.In reaction tray 1 and examination
Reagent is set to dispense mechanism 7,8 between agent disk 9.Between reaction tray 1 and Sample transportation mechanism 17 set can rotate and on move down
Dynamic sample dispensing mechanism 11, possesses sample probe 11a.Connect sample syringe 19 respectively on sample probe 11a.Sample
Probe 11a centered on rotary shaft while describe circular arc while movement, carries out the sample dispensing from sample container to reaction member.
Pressure sensor 40 detects the pressure of the runner inside sample probe.
Preparation wiper mechanism 3, spectrophotometer 4, rabbling mechanism 5,6, reagent disc 9 and sample around reaction tray 1
Carrying mechanism 17, flushing pump 20 is connected on wiper mechanism 3.Mechanism 7,8, sample dispensing mechanism 11, stirring are dispensed in reagent
Rinse bath 13,30,31,32,33 is set respectively on the actuating range of mechanism 5,6.Reagent is connected in reagent dispensing mechanism 7,8 to use
Syringe 18.Sample is checked containing blood etc. in sample container 15, is positioned on frame 6 and is transported by Sample transportation mechanism 17.
In addition, each mechanism is connected on controller 21.Above is the structure of automatic analysing apparatus.
Then the embodiment of this patent is illustrated.
Fig. 4 A represent in pressure sensor 40, the discharge pressure as caused by sample probe 11a chocking-up degree waveform
Change, i.e. negative pressure peak and the change of residual voltage value.In Figure 4 A, represent using the passage of time as transverse axis, by moment t0
Opening sample with the magnetic valve in syringe 19 and flows out rinse water, and it is certain to make discharge pressure, by being closed in moment t1
Magnetic valve of the sample in syringe 19, according to sample probe 11a chocking-up degree, discharge pressure becomes as (a) to (e)
Change.In addition, in order to simple, in Figure 4 A, it is 0 to make atmospheric pressure.
First, in the case where sample probe 11a is not blocked, such as shown in (a), magnetic valve moment t1 close soon it
Discharge pressure afterwards is not 0 at once, is temporarily negative pressure P1 due to the inertia force of rinse water, is 0 after somewhat vibrating.Then, examination is worked as
When sample probe 11a chocking-up degree increases and closed, such as shown in (b), because the resistance in sample probe 11a becomes big, in runner
The inertia force of cleaning fluid is reduced, and therefore, the size of negative pressure peak diminishes.In addition, when sample probe 11a chocking-up degree increase
When, such as shown in (c), negative pressure is 0 (P2).In the case that the negative pressure of from (a) to (c) is more than 0 more than, think that sample is visited for the time being
Pin 11a dispensing precision is in reliable scope.
In addition, when sample probe 11a chocking-up degree increase and occlusion progress, as shown in (d) oblique line, residual voltage is produced,
When occlusion is further in progress and entirely shut, as shown in (e) oblique line, discharge pressure can not revert to 0, and residual voltage keeps certain value
Without changing.
Here, in the case where starting analysis as shown in Figure 2, before liquor sample is attracted, carry out in sample probe
With the presence or absence of the diagnosis blocked in 11a.Diagnostic method is by opening magnetic valve 35 and sample probe 11a being carried out in rinse bath 13
The cleaning 203 of inner side, magnetic valve 35 is being closed after required time, whether determining the pressure in sample probe 11a required
Atmospheric pressure is returned in time (t) or returns to the time (diagnosis 204 before attracting) of atmospheric pressure.If not Fig. 4 A (d) (e) state,
The as situation of Fig. 4 A (a) (b) (c), then it is judged as normal.It is being judged as " after attracting OK ", starting ensuing to detection
The dispensing action of body.Here, so-called " attract OK " to represent that the state of removing action need not be blocked, so-called " attraction NG " is represented
Fig. 4 (d) (e) situation is, it is necessary to block the state of removing action.Such case can be by whether return within the above-mentioned stipulated time
Return atmospheric pressure or return to the time judgement of atmospheric pressure.
Or to being diagnosed before Fig. 2 attraction, can also be by after sample probe 11a inner side is cleaned, closing magnetic valve
After 35, Air attractions are carried out with syringe 19 using sample.After carrying out Air attractions with the action of syringe 19 using sample, when trying
When sample probe 11a is not blocked, as shown in Figure 4 B, in time T2, the pressure in sample probe 11a returns to atmospheric pressure.Such as figure
Shown in 4C, there is a situation where not returning to atmospheric pressure (solid line) in time T2, gradually return to the situation (dotted line) of atmospheric pressure, but
In the case that until the time, T2 does not return to atmospheric pressure, it is judged as " attracting NG " in diagnosing 204 before attraction.Sample probe 11a's
Fore-end is acted by Air attractions, Air enter, but the Air by after block measuring is implemented open magnetic valve 35, can
Water is filled up to front end, therefore, the decline of device processing speed will not be caused.In addition, the equal transverse axis of Fig. 4 B, C is the time, with arrow
The Range Representation of expression carries out the time range of syringe attraction action.In addition, time T2 is set as attracting to move in the syringe
Work terminated and after certain time.By detecting the pressure in time T2, it can interpolate that (diagnosis) with the presence or absence of blocking.
So, before liquor sample attraction, diagnosis includes the state of the flow passage system in sample probe 11a, according to runner
The diagnostic result of system, it can interpolate that the state (" attract OK ") that can attract liquid or in the state of it can not attract liquid
Need the state (" attract NG ") that runner cleans.Additionally, it is desirable to before the attraction of liquor sample, it is necessary to diagnose the shape of flow passage system
State.
When be judged as in pressure after closing magnetic valve 35 " attract NG " when, implement block remove cleaning 205 action.It is logical
It is judged as " attracting NG ", device does not also stop analyzing, in a circulation of dispensing circulation even if crossing and blocking the action for removing cleaning 205
Carry out blocking the action for removing cleaning 205, decline device disposal ability and rest on irreducible minimum.Cleaned blocking to remove in 205,
Rinse water is discharged from the inside of sample probe, is removed and blocked using the pressure of the rinse water.So, before being attracted according to liquid
Including flow passage system in sample probe state diagnostic result, liquor sample attracts to be judged as not carrying out (" attracting
NG ") when, it is controlled in a manner of making to include the flow passage system in sample probe and returning to normal condition.Return to the normal shape
The control such as control unit 50 of state makes the magnetic valve 35 of opening and closing cleaning fluid runner carry out action while syringe is repeated
Attraction, discharging operation.
Common sample probe 11a sample probe cleaning 203 needs the rotating of sample probe 11a, upper and lower action flower
The time taken, therefore, compared with the action that cleaning 205 is removed with blocking, the time for cleaning cost is few.On the other hand, implement to block
When removing cleaning 205, sample probe 11a, at least without spinning movement, therefore, is removed clearly from the position of rinse bath 13 blocking
Wash in 205, scavenging period can be more set.Because until block measuring 206 terminates, sample probe 11a is in rinse bath
13 position is standby.
In addition, after removing cleaning 205 is blocked, implement block measuring 206.This is to be identified through implementation blocking and remove
Go whether cleaning 205 removes blocking." in the case of attracting OK ", it is being controlled in a manner of carrying out sample attraction, the opposing party
Face, " in the case of attracting NG ", carrying out blocking again removing and cleaning 205., can also be even if being removed to the blocking again
The time of one circulation, which all carries out blocking, removes cleaning 205, and cleaning 205 is removed with the blocking converged to again again in a circulation
Mode, shorten the time for blocking and removing cleaning 205, blocking again can be made to remove cleaning and converged in a circulation.
Fig. 3 represents the detailed of cleaning method.Fig. 3 is to represent the cleaning solution supplying from dispensing runner washed samples probe interior
The figure of unit.Sample attracts discharge liquor sample with syringe 19 to sample probe 11a, is visited in sample with syringe 19 and sample
Have between pin 11a and connect their dispensing runner.The dispensing runner utilizes branch components 34 to the side branch of pressure sensor 40.
It is connected on A/D converter 55 by amplifier 54 by the pressure signal that pressure sensor 40 detects, and is passed as pressure signal
It is delivered to personal computer 51.Personal computer 51 exchanges signal, Control Assay probe actuation unit 52, dispensing note with control unit 50
Emitter driver element 53, magnetic valve 35.Supply of the rinse water 37 to sample probe 11a is using the opening and closing of magnetic valve 35, and control is clearly
The opening and closing of washing lotion runner, rinse water 37 are picked up by pump 36.As shown in figure 3, in the position of rinse bath 13, visited using pump 36 to sample
Apply the pressure of high pressure in pin 11a, by opening magnetic valve 35, the sample in sample probe 11a can be released, cleaned,
After closing magnetic valve 35, block the measure 206 of removing.In addition, Air attraction actions are carried out with syringe 19 using sample,
Here, it is being judged as again " in the case of attracting NG ", as shown in Fig. 2 removing cleaning 205, Zhi Dao to being repeated to block
Block and remove in measure 206 as " attraction OK " implements also not arresting stop repeatedly, and it is effective to carry out dispensing.
In addition, as the method for blocking removing cleaning 205, following method is enumerated.
First method, advance with pump 36 and the certain time of magnetic valve 35 is opened in the state of high pressure.In the action
In, as already mentioned as, compared with common sample probe cleaning 203, block and remove cleaning and 205 can more use
Time, therefore, it is effective that the blocking in sample probe 11a, which is removed,.
The opening and closing of second method magnetic valve 35 repeatedly, pressure is applied with the foreign matter pulsed to blocking, and to sample probe
Mode extrapolated 11a is also effective.Here, the opening/closing time of magnetic valve 35 can make opening time with the shut-in time be phase
With time, it is more than opening time to turn off the time, or makes opening time more than the shut-in time.In addition, magnetic valve 35
The number of occurrence of opening and closing pressure caused by being opened due to magnetic valve 35, which is descended through, closes magnetic valve 35, is provided until returning
Pressure time with can block remove cleaning 205 action spend time in, be not particularly limited, can be appropriate
Set in advance.
Alternatively, it is also possible to being the combination of the two methods.For example, be before attraction diagnosis 204 in turn into " attract NG ",
Need in the case of implementing to block the action for removing cleaning 205 repeatedly, apply certain higher pressure (first side for the first time
Method), second of method for applying pressure (second method) with pulsation in the on-off action of magnetic valve 35.In addition, with
In the case of third time, it is also considered that carry out blocking removing cleaning in the opening/closing time of the magnetic valve 35 different from second for the third time
205.In the case where implementing repeatedly to block the action for removing cleaning 205, it is expected to change the side for blocking and removing cleaning 205 respectively
Method.Because exist due to once for " attract NG ", therefore with identical block remove cleaning 205 action in can not the phase
Treat the situation of effect.By using multiple methods, the effect that higher blocking removes can be expected.Therefore, including in sample probe
The cleaning repeatedly of flow passage system it is expected cleaning repeatedly every time, the control of magnetic valve is different.Change to block and remove cleaning 205
Method not only changes the above method, also changes the pressure value of high pressure using first method or utilizes second method
Change the situation of the opening/closing time of magnetic valve 35.
3rd method is magnetic valve 35 is opened certain time with the state of high pressure using pump 36, during this period, is made
Sample carries out Air with syringe 19 and attracted until maximum traffic attraction, implements the action that discharge has attracted the volume of maximum traffic attraction
Method.In addition, in the cleaning using pump 36, attraction, the discharging operation of sample syringe 19 are repeated using implementation
Action method, outside the high pressure from pump 36 applied using above-mentioned first method is released, also apply sample and inject
The pressure of the discharge of device 19, therefore, it is possible to effectively remove the foreign matter of blocking.
As other application example, also consider as follows.Cleaning action after being terminated using dispensing obtains what is each circulated
Fig. 4 A, Fig. 4 B pressure waveform after, waveform when storage begins to use new sample probe 11a block measuring 204, such as such as
Fruit is judged as Fig. 4 (A) (c) state, then sends the alarms such as sample probe 11a replacing period to user as device.Or
Person is in the state of (c) for Fig. 4 (A), before sample probe 11a is completely plugged, utilizes a circulation or the spray of a circulation above
Mouth removes cleaning action 205, turns into the reliability that the state that sample probe 11a is continuously dispensed can be made to improving device in advance
It is effective.
Then, it is above-mentioned to list the example that a variety of samples are dispensed with a sample probe, it is exemplified below being equipped with two examinations
Sample attracts the example of sample probe.As shown in figure 5, sample probe 11a is the sample probe of the samples such as special dispensing blood, urine,
Sample probe 12a be dispensing viscosity it is high and easily produce the blood cell blocked, whole blood HbA1c measure special sample probe
12a.In sample probe 12a, blocking is produced in block measuring 204, even if implementing nozzle repeatedly removes the dynamic of cleaning 205
Make, sample probe 11a can also continue dispensing action, therefore, continue to analyze with can not stopping measure as device.
The number of occurrence N that sample probe 12a nozzle removes cleaning 205 it is expected that device users can set wash number.
Assuming that attracting position to have frame 16 in the sample probe 12 shown in Fig. 5, detection sample probe 12a produces blocking in dispensing, real
Apply nozzle and remove cleaning 205.In nozzle once removes cleaning action 205, when the stream for not solving to implement Fig. 2 repeatedly with blocking
Cheng Shi, it is that can not be moved to next shift position and standby state to attract the frame 16 of position positioned at sample probe 11a.At this
In the case of, in order to which sample probe 11a out of question can dispense sample, cause the disposal ability decline as device.Therefore, it is desirable to
Can clean repeatedly can arbitrarily set wash number (N) in advance including the flow passage system in sample probe, device users.
In addition, using before sample probe 12a dispensing commission understanding, therefore, it is judged as " blocking in sample probe 12a
Remove NG " after, proceed to using next sample probe 12a start dispensing commission wash number repeatedly can be set as spraying
Mouth removes the maximum number of occurrence N of cleaning 205.
In addition, for the establishing method of wash number, as sample probe 11a for example, if maximum standby three circulate, then
The establishing method for the wash number that the nozzle for terminating sample probe 12a removes cleaning action 205 etc is also effective.Now,
The action involution of cleaning 205, during sending alarm and determining cancellation, sample can not be removed due to nozzle in sample probe 12a
Probe 11a is the state that can be analyzed, and therebetween, sample probe 11a is continuously analyzed.Implement nozzle in sample probe 12a to remove
During going cleaning 205, frame 16 does not dispense ground in sample probe 12a positions only by the way that but sample probe 12a is in sample probe 11a
During being acted, nozzle can be implemented repeatedly in advance and remove cleaning action 205 and block measuring 206.Thus, can be by spraying
Mouth removes the block measuring 206 after cleaning 205 and confirmed after removing foreign matter, by returning to common operation, can be pointed to device
The interior detection body that there is measure to entrust does not cancel dispensing ground all using sample probe 12a measure.For example, removing foreign matter
Stage sounds all clear or produced the information for the content for relieving alarm, can notify operating personnel.
In addition, also having due to determining pressure value every time in removing cleaning 205 in nozzle, therefore, prestore for the first time
Nozzle removes the pressure waveform at the end of cleaning 205, the pressure waveform after the nozzle after n-th removes cleaning action 205
In the case of first time no change, terminate the action that nozzle removes cleaning 205, it may have cancellation sample probe 12a point
The number of occurrence N of note etc setting.
In addition, in above-mentioned, carried out with the example for the measure 204 for implementing to block after sample probe 11a (12a) cleaning
Record, but except cleaning after, by using sample probe 11a (12a) sample attract when implement, whether be able to confirm that can be just
Often attract sample using sample probe 11a (12a).In addition, by implementing the survey blocked in washed samples probe 11a (12a)
Whether fixed 204, reaction vessel can be normally discharged to by being able to confirm that.By sample attract or sample probe 11a (12a) it is clear
Confirm when washing, the dispensing reliability of device can be improved.
In the description in fig. 5, cleaning is removed to the block measuring using sample probe 12a and blocking to be recorded, but
Sample probe 11a can also be utilized to implement to block removing cleaning action 205, be not limited to sample probe 12a.
Symbol description
1-reaction tray, 2-reaction vessel, 3-wiper mechanism, 4-spectrophotometer, 5-rabbling mechanism, 6-mixer
Structure, 7-reagent dispensing mechanism, 8-reagent dispensing mechanism, 9-reagent disc, 10-reagent bottle, 11-sample dispensing mechanism,
11a-sample probe, 12-sample dispensing mechanism, 12a-sample probe, 13-rinse bath, 14-rinse bath, 15-sample hold
Device, 16-frame, 17-Sample transportation mechanism, 18-reagent syringe, 19-sample syringe, 20-flushing pump,
21-controller, 30-rinse bath, 31-rinse bath, 32-rinse bath, 33-rinse bath, 34-branch components, 35-electromagnetism
Valve, 36-pump, 37-rinse water, 38-supply tank, 40-pressure sensor, 50-control unit, 51-personal computer, 52-
Sample probe driver element, 53-dispensing injector drive unit, 54-amplifier, 55-A/D converter, 201-attract to move
Make, 202-discharging operation, the cleaning of 203-sample probe, diagnosed before 204-attraction, 205-block to remove and clean, 206-stifled
Plug measure.
Claims (4)
1. a kind of automatic analysing apparatus, has liquor sample dispensing mechanism, liquor sample dispensing mechanism includes sample probe, made
Said sample probe attract discharge liquor sample syringe, connection said sample probe and said syringe dispensing runner,
Cleaning fluid is supplied into the runner with being connected in sample probe and sample probe inside is cleaned from above-mentioned dispensing runner
Cleaning solution supplying unit, the cleaning fluid runner for connecting above-mentioned cleaning solution supplying unit and said syringe, detect in sample probe
The pressure sensor of the pressure of the runner in portion and the magnetic valve that above-mentioned cleaning fluid runner is opened and closed, the automatic analysing apparatus
It is characterised by,
Following processing are repeated with the attraction number of liquor sample：First processing, it is attracting the liquid examination of blood cell or whole blood
Before sample, the front end that the air of said sample probe attracts and makes water be filled up to said sample probe after air attraction is carried out；
And second processing, it is carried out the liquor sample of above-mentioned blood cell or whole blood using said sample probe after the above-mentioned first processing and inhaled
Draw,
Each liquor sample attract it is above-mentioned first processing above-mentioned second processing between, based on the air attract after by upper
Negative pressure value or residual voltage value that pressure sensor obtains are stated, diagnosis includes the blocked state of the flow passage system in sample probe, according to
The diagnostic result of flow passage system, judgement are to attract the state of liquor sample, or in the state of it can not attract liquor sample
The state for needing runner to clean.
2. automatic analysing apparatus according to claim 1, it is characterised in that
The blocked state of flow passage system before according to the liquor sample for attracting blood cell or whole blood including in sample probe is examined
Disconnected result, is judged as in the case of can not attracting liquor sample, while making the above-mentioned electricity that above-mentioned cleaning fluid runner is opened and closed
Magnet valve is acted, while the attraction of syringe, discharging operation is repeated, is made to include the flow passage system in sample probe and is returned
Normal state.
3. automatic analysing apparatus according to claim 2, it is characterised in that
It can repeatedly clean including the flow passage system in sample probe, can arbitrarily set wash number.
4. automatic analysing apparatus according to claim 3, it is characterised in that
In cleaning repeatedly every time, the control of above-mentioned magnetic valve is different for cleaning repeatedly including the flow passage system in sample probe.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012166493A JP6018828B2 (en) | 2012-07-27 | 2012-07-27 | Automatic analyzer |
| JP2012-166493 | 2012-07-27 | ||
| PCT/JP2013/068583 WO2014017276A1 (en) | 2012-07-27 | 2013-07-08 | Automated analyzer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104508494A CN104508494A (en) | 2015-04-08 |
| CN104508494B true CN104508494B (en) | 2018-01-05 |
Family
ID=49997092
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380039214.3A Active CN104508494B (en) | 2012-07-27 | 2013-07-08 | Automatic analysing apparatus |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9709586B2 (en) |
| EP (1) | EP2878955B1 (en) |
| JP (1) | JP6018828B2 (en) |
| CN (1) | CN104508494B (en) |
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| JP6824219B2 (en) * | 2018-04-26 | 2021-02-03 | 日本電子株式会社 | Automatic analyzer and automatic analysis method |
| CN111570422A (en) * | 2019-02-18 | 2020-08-25 | 深圳迎凯生物科技有限公司 | Sampling needle cleaning device and method |
| JP7261616B2 (en) * | 2019-03-04 | 2023-04-20 | 株式会社日立ハイテク | automatic analyzer |
| JP7467309B2 (en) * | 2020-10-08 | 2024-04-15 | キヤノンメディカルシステムズ株式会社 | Automatic analyzer and cleaning method |
| CN112222121A (en) * | 2020-10-20 | 2021-01-15 | 武汉生之源生物科技股份有限公司 | Cleaning device and immunoassay appearance of reaction tube |
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| CN104508494A (en) | 2015-04-08 |
| EP2878955A4 (en) | 2016-03-16 |
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| US20150192600A1 (en) | 2015-07-09 |
| JP2014025816A (en) | 2014-02-06 |
| US9709586B2 (en) | 2017-07-18 |
| JP6018828B2 (en) | 2016-11-02 |
| EP2878955B1 (en) | 2018-09-05 |
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