CN104491795A - Traditional Chinese medicine composition for treating rheumatoid arthritis - Google Patents

Abstract

The invention belongs to the technical field of medicines and discloses a traditional Chinese medicine composition for treating rheumatoid arthritis. The traditional Chinese medicine composition is mainly prepared from the following raw materials in parts by weight: 11-33 parts of ledebouriella seseloides, 11-33 parts of angelica sinensis, 5-15 parts of rhizoma drynariae, 3-12 parts of fructus psoraleae, 3-12 parts of epimedium, 3-12 parts of dried whole scorpion, 3-12 parts of dipsacus root, 3-12 parts of dried ginger, 1-6 parts of radix astragali and 11-33 parts of glycyrrhiza uralensis. The traditional Chinese medicine composition disclosed by the invention can interact, has the effects of nourishing the liver and kidneys, detoxifying and reducing swelling, dispelling wind and eliminating dampness, promoting blood circulation and dredging collaterals, strengthening the muscles and bones, expelling wind and clearing away cold and strengthening the body resistance to eliminate pathogenic factors during combined use, and can be used as a medicine for treating rheumatoid arthritis.

Description

A kind of Chinese medicine composition for the treatment of rheumatoid arthritis

Technical field

The invention belongs to medical art, relate to a kind of Chinese medicine composition for the treatment of rheumatoid arthritis and preparation method thereof.

Background technology

Rheumatoid arthritis (RA) is not bright chronic, the systemic disease based on inflammatory synovitis of a kind of cause of disease.It is characterized in that the multi-joint of hands, sufficient Minor articulus, symmetry, aggressive arthritis, often involved the serum rheumatoid factor (SRF) positive with organ outside joint, joint deformity and afunction can be caused.

Rheumatoid arthritis can with losing weight, the General Symptoms such as low grade fever and tired sense.1) morning is stiff: the inflexible subjective sensation of WA joint motion in morning, it is the non-specific performance of one of arthritis, and its persistent period is directly proportional to the order of severity of inflammation.2) performance of joint involvement 1. multi-joint to get involved symmetrically property polyarthritis (normal >=5 joints).There are hands, foot, wrist, ankle and temporomandibular joint etc. in the joint of easily getting involved, and other also can have elbow, shoulder, cervical vertebra, hip, knee joint etc.2. the deformity of joint deformity hands has fusiformis swelling, ulnar side deflection, swan neck deformity, buttonhole style deformity etc.What sufficient deformity had the downward subluxation of head of metatarsal bone to cause faces upward microdactyly, valgus deformity, metatarsophalangeal joints subluxation, bends in hammer toe and talipes valgus.3. other Wan Guan ∕ tarsal tunnel syndromes that median nerve/posterior tibial nerve pressurized can be had to cause, Articular effusion in knee joint clamp-ons Xing Cheng popliteal cyst (Baker cyst) on rear side of joint, cervical vertebra is got involved (the 2nd, 3 cervical vertebras common) can have cervical pain, neck weakness and be difficult to keep its normal position, atlanto-axial subluxation, should have the performance of compression of spinal cord and vertebro-basilar artery insufficiency mutually.3) 1. extra-articular manifestation generally shows can heating, rheumatoid nodules (belongs to the granuloma of machine, relevant with high titre RF, serious destruction of joint and RA activity, be apt to occur in the knuckle portions, joint such as ancon, joint olecranon are prominent, sacrum portion and frequent pressurized place), rheumatoid vasculitis (mainly involve arteriolar necrotizing arteriolitis, finger, toe end necrosis, skin ulcer, peripheral neuropathy etc. can be shown as) and lymphadenectasis.2. Cardiac Involvemant can have tuberosity, myocarditis, coronaritis, aortitis, the conductive impairment of pericarditis, pericardial effusion, visceral pericardium, cardiac muscle and valve, the performances such as chronic endocarditis and cardiac valve fibrosis.3. respiratory system is got involved can pleuritis, hydrothorax, pulmonary arteritis, interstitial lung disease, nodositas pneumonopathy etc.4. kidney performance mainly contains primary glomerular and tubulointerstitial nephritis, kidney amyloidosis and is secondary to the renal damage of Drug therapy (golden preparation, penicillamine and NSAIDs).5. nervous system is except the symptom of peripheral nerve pressurized, also can inducing neural disease, myelopathy, peripheral neurophaty, be secondary to vasculitic ischemia neuropathy, muscular hypertrophy and drug-induced nervous system lesion.6. anemia is the modal extra-articular manifestation of RA, belongs to study on anemia of chronic disease, is often mild to moderate.7. digestive system can because of caused by RA vasculitis, complication or Drug therapy.8. eye juvenile patient can have uveitis, and adult can have scleritis, may caused by vasculitis.Also can there be the perforation of drying property conjunctivokeratitis, scleromalacia, scleromalacia, corneal solution.4) the RA patient of Felty syndrome 1% can have splenomegaly, Neutrophilic granulocytopenia (and thrombocytopenia, red blood cell count(RBC) reduce), often has RF and ANA of serious arthropathy, high titre positive, belongs to a kind of Severe RA.5) palliative seronegativity, symmetry synovitis companion pitting edema syndrome (RS3PE) male are common, often in 55 years old with sequela, in acute onset, have the inflammation of symmetry carpal joint, flexor tendon sheath and hands Minor articulus, the back of the hand can have pitting edema.Stiff time in morning long (0.5 ~ 1 day), but RF is negative, and x-ray does not have osteoclasia more.There is the patient of 56% for the HLA-B7 positive.Poor to alone NSAIDs drug reaction in treatment, and low dose of glucocorticoid is evident in efficacy.Often spontaneous remission after 1 year, good prognosis.6) a kind of rare RA type that alternately occurs with alleviation with the acute attack of high heat, arthritis, erythra etc. of adult Still disease (AOSD).Gain the name because clinical manifestation is similar to whole body disease type juvenile rheumatoid arthritis (Still is sick).Some patients changes typical RA into through outbreak for several times.7) RA of Late-onset normal >65 year onset, sex difference is little, how in acute onset, development very fast (part be show at first with OA, occurs that typical RA shows after several years).With brothers' edema, canalis carpi and tarsal tunnel syndrome and polymyalgia for outstanding behaviours, morning is obviously stiff, and 60% ~ 70%RF is positive, but titre is much lower.X-ray is based on osteoporosis, and little aggressive changes.Complication such as patient Chang Yin cardiovascular, infection and impaired renal function and dead.Select NSAIDs to want prudent, low dose of hormone can be applied, to acting on antirheumatic (SAARD) reaction slowly better.

The main purpose for the treatment of rheumatoid arthritis is that ameliorate osteoarthritis disease is reacted, and suppresses pathological development and irreversible bone destruction, the as far as possible function of Saving cortilage and muscle, finally reaches the target of state of an illness complete incidence graph or low disease activity.Drug therapy mainly comprises nonsteroidal anti-inflammatory agent, acts on antirheumatic, immunosuppressant, immunity and biological preparation and plant amedica etc. slowly.1) nonsteroidal anti-inflammatory agent has antiinflammatory, pain relieving, refrigeration function, is medicine the most conventional in treating rheumatoid arthritis, is applicable to the patient in each periods such as active stage.Conventional medicine comprises diclofenac, nabumetone, meloxicam, celecoxib etc.2) antirheumatic (DMARDs) is otherwise known as Second line Drug or act on antirheumatic slowly.Conventional has methotrexate, oral or quiet note; Sulfasalazine, from low dose, increases progressively gradually, and oxychloroquine, leflunomide, ciclosporin, auranofin, Radix Paeoniae Alba total glucosides etc.3) glucocorticoid, 4) biological preparation, 5) plant amedica, the existing multiple plant amedica for rheumatoid arthritis, as Radix Tripterygii Wilfordii, white peony root's total glycoside, sinomenine etc.

Summary of the invention

The invention provides a kind of Chinese medicine composition for the treatment of rheumatoid arthritis.

The technical scheme that the present invention takes is as follows:

Treat a Chinese medicine composition for rheumatoid arthritis, be prepared from by the raw material of following weight portion:

Radix Saposhnikoviae 11-33, Radix Angelicae Sinensis 11-33, Rhizoma Drynariae 5-15, Fructus Psoraleae 3-12, Herba Epimedii 3-12, Scorpio 3-12, Radix Dipsaci 3-12, Rhizoma Zingiberis 3-12, Radix Astragali 1-6, Radix Glycyrrhizae 11-33.

As optimal technical scheme, the present invention treats the Chinese medicine composition of rheumatoid arthritis, is prepared from by the raw material of following weight portion:

Radix Saposhnikoviae 24, Radix Angelicae Sinensis 24, Rhizoma Drynariae 10, Fructus Psoraleae 6, Herba Epimedii 6, Scorpio 4, Radix Dipsaci 4, Rhizoma Zingiberis 6, the Radix Astragali 3, Radix Glycyrrhizae 18.

Two of the object of the invention there is provided a kind of preparation method for the treatment of the Chinese medicine composition of rheumatoid arthritis, and concrete steps are as follows:

1) take each traditional Chinese medicinal material raw materials by proportioning, then put into Chinese medicine grinder respectively and pulverize, grinding and sieving;

2) fine drug powder of the Radix Saposhnikoviae of step 1) being prepared, Radix Angelicae Sinensis, Rhizoma Drynariae, Fructus Psoraleae, Rhizoma Zingiberis, the Radix Astragali, Radix Glycyrrhizae adds in container, adds the dehydrated alcohol of 6-10 times amount, reflux, extract, 1-3 hour, collects extracting solution after cooling;

3) toward step 2) add the water of 3-6 times amount in gained medicinal residues, reflux, extract, 1-4 hour, collects extracting solution after cooling;

4) merge the extracting solution of twice, leave standstill and obtain supernatant; It is the thick paste of 1.10-1.20 that supernatant heating is concentrated into relative density at 60 DEG C;

5) in thick paste, add the fine drug powder of Herba Epimedii, Scorpio, Radix Dipsaci, drying obtains dry extract;

6) carried out by dry extract pulverizing, sieving, add adjuvant, mixing, makes required dosage form according to a conventional method.

The present invention treat the middle compositions determined curative effect of rheumatoid arthritis and also therapeutic effect good, can expelling wind and removing dampness, removing toxic substances and promoting subsidence of swelling, promoting blood circulation to remove obstruction in the collateral, nourishing the liver and kidney, strengthening the tendons and bones and strengthening vital QI to eliminate pathogenic factors.Prove through clinical trial, traditional Chinese medicine composition for treating rheumatoid arthritis cure rate of the present invention is high, due to existing medicine, can promote the use of.

Detailed description of the invention

Further describe the present invention below by way of detailed description of the invention, but the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, Chinese medicine composition of the present invention is suitably improved, replaces the identical component of effect, will become apparent to those skilled in the art that they are all deemed to be included within scope of the present invention.

Embodiment 1

Formula (kg):

Radix Saposhnikoviae 22, Radix Angelicae Sinensis 30, Rhizoma Drynariae 6, Fructus Psoraleae 6, Herba Epimedii 4, Scorpio 5, Radix Dipsaci 5, Rhizoma Zingiberis 12, Huang 6, Radix Glycyrrhizae 20.

Preparation method:

1) take each traditional Chinese medicinal material raw materials by proportioning, then put into Chinese medicine grinder respectively and pulverize, after pulverizing, obtain coarse powder;

2) fine drug powder of the Radix Saposhnikoviae of step 1) being prepared, Radix Angelicae Sinensis, Rhizoma Drynariae, Fructus Psoraleae, Rhizoma Zingiberis, the Radix Astragali, Radix Glycyrrhizae adds in container, adds the dehydrated alcohol of 10 times amount, and reflux, extract, 2 hours, collects extracting solution after cooling;

3) toward step 2) add the water of 3 times amount in gained medicinal residues, reflux, extract, 2 hours, collects extracting solution after cooling;

4) merge the extracting solution of twice, leave standstill and obtain supernatant; It is the thick paste of 1.10-1.20 that supernatant heating is concentrated into relative density at 60 DEG C;

5) in thick paste, add the fine drug powder of Herba Epimedii, Scorpio, Radix Dipsaci, drying obtains dry extract;

6) carried out by dry extract pulverizing, crossing 150 mesh sieves, add adjuvant, mixing, makes granule according to a conventional method.

Embodiment 2

Formula (kg):

Radix Saposhnikoviae 24, Radix Angelicae Sinensis 24, Rhizoma Drynariae 10, Fructus Psoraleae 6, Herba Epimedii 6, Scorpio 4, Radix Dipsaci 4, Rhizoma Zingiberis 6, the Radix Astragali 3, Radix Glycyrrhizae 18

Preparation method:

1) take each traditional Chinese medicinal material raw materials by proportioning, then put into Chinese medicine grinder respectively and pulverize, after pulverizing, obtain coarse powder;

2) fine drug powder of the Radix Saposhnikoviae of step 1) being prepared, Radix Angelicae Sinensis, Rhizoma Drynariae, Fructus Psoraleae, Rhizoma Zingiberis, the Radix Astragali, Radix Glycyrrhizae adds in container, adds the dehydrated alcohol of 10 times amount, and reflux, extract, 3 hours, collects extracting solution after cooling;

3) toward step 2) add the water of 6 times amount in gained medicinal residues, reflux, extract, 2 hours, collects extracting solution after cooling;

4) merge the extracting solution of twice, leave standstill and obtain supernatant; It is the thick paste of 1.10-1.20 that supernatant heating is concentrated into relative density at 60 DEG C;

5) in thick paste, add the fine drug powder of Herba Epimedii, Scorpio, Radix Dipsaci, drying obtains dry extract;

6) carried out by dry extract pulverizing, crossing 150 mesh sieves, add adjuvant, mixing, makes capsule according to a conventional method, and every containing crude drug 0.5g.

Embodiment 3

Formula (kg):

Radix Saposhnikoviae 11, Radix Angelicae Sinensis 12, Rhizoma Drynariae 12, Fructus Psoraleae 12, Herba Epimedii 12, Scorpio 12, Radix Dipsaci 12, Rhizoma Zingiberis 12, the Radix Astragali 6, Radix Glycyrrhizae 33.

Preparation method:

1) take each traditional Chinese medicinal material raw materials by proportioning, then put into Chinese medicine grinder respectively and pulverize, after pulverizing, obtain coarse powder;

2) fine drug powder of the Radix Saposhnikoviae of step 1) being prepared, Radix Angelicae Sinensis, Rhizoma Drynariae, Fructus Psoraleae, Rhizoma Zingiberis, the Radix Astragali, Radix Glycyrrhizae adds in container, adds the dehydrated alcohol of 8 times amount, and reflux, extract, 2 hours, collects extracting solution after cooling;

3) toward step 2) add the water of 4 times amount in gained medicinal residues, reflux, extract, 2 hours, collects extracting solution after cooling;

4) merge the extracting solution of twice, leave standstill and obtain supernatant; It is the thick paste of 1.10-1.20 that supernatant heating is concentrated into relative density at 60 DEG C;

5) in thick paste, add the fine drug powder of Herba Epimedii, Scorpio, Radix Dipsaci, drying obtains dry extract;

6) carried out by dry extract pulverizing, crossing 150 mesh sieves, add adjuvant, mixing, makes tablet according to a conventional method, and every sheet is containing crude drug 0.5g.

Embodiment 4

Formula (kg):

Radix Saposhnikoviae 33, Radix Angelicae Sinensis 22, Rhizoma Drynariae 11, Fructus Psoraleae 11, Herba Epimedii 11, Scorpio 7, Radix Dipsaci 8, Rhizoma Zingiberis 4, the Radix Astragali 4, Radix Glycyrrhizae 33.

Preparation method:

1) take each traditional Chinese medicinal material raw materials by proportioning, then put into Chinese medicine grinder respectively and pulverize, after pulverizing, obtain coarse powder;

2) fine drug powder of the Radix Saposhnikoviae of step 1) being prepared, Radix Angelicae Sinensis, Rhizoma Drynariae, Fructus Psoraleae, Rhizoma Zingiberis, the Radix Astragali, Radix Glycyrrhizae adds in container, adds the dehydrated alcohol of 8 times amount, and reflux, extract, 2 hours, collects extracting solution after cooling;

3) toward step 2) add the water of 4 times amount in gained medicinal residues, reflux, extract, 2 hours, collects extracting solution after cooling;

4) merge the extracting solution of twice, leave standstill and obtain supernatant; It is the thick paste of 1.10-1.20 that supernatant heating is concentrated into relative density at 60 DEG C;

5) in thick paste, add the fine drug powder of Herba Epimedii, Scorpio, Radix Dipsaci, drying obtains dry extract;

6) carried out by dry extract pulverizing, crossing 150 mesh sieves, add adjuvant, mixing, makes oral liquid according to a conventional method.

clinical data:

1, MethodsThe cases enrolled diagnostic criteria

Adopt ARA diagnostic criteria in 1987.Rheumatoid arthritis feelings activity standard:

(1) moderate during rest pain;

(2) morning, the stiff time was more than or equal to 1 hour;

More than (3) three arthroncuss;

(4) articular pain is more than or equal to 5 joints;

(5) ESR is greater than 28mm/hr.

Meet above 4 namely diagnosable.

2, physical data

Experiment observes 200 routine patient with rheumatoid arthritis altogether, and all patients are divided into two groups at random, treatment group 120 example, and matched group 80 example, two groups of patient ages, sex, symptoms verify that through statistics zero difference has comparability.

3, Therapeutic Method

Treatment group: take capsule prepared by the embodiment of the present invention 2, each 6,3 times on the one;

Matched group: give conventional western medicine treatment (taking leflunomide, methotrexate and folic acid).

Continuous treatment 30 days.

4, evaluation of clinical curative effect standard

To joint swelling index, articular pain index, morning is stiff, grip, and ESR, RF examine, and the improvement degree of every index is calculated as follows:

Value × 100% before (before treatment the rear value of value-treatment)/treatment;

ESR calculates:

(before treatment the rear value of value-treatment)/(before treatment value-normal value) × 100%;

(male normal value is less than or equal to 15mm/hr, and female is less than or equal to 20mm/hr)

Curative effect classification:

Calculate the improvement percent of indices, addition calculates it and on average improves percent to judge curative effect.

Effective: than before treatment after treatment, improvement rate >=70%.

Effective: than before treatment after treatment, 50%≤improvement rate < 70%.

Improve: than before treatment after treatment, 30%≤improvement rate < 50%.

Invalid: than before treatment after treatment, improvement rate < 30%.

5, therapeutic outcome

Two groups of therapeutic outcomes, ginseng is shown in Table 1.

Table 1, two groups for the treatment of curative effects

Group	Number of cases	Effective	Effectively	Improve	Invalid	Total effective rate (%)
							Treatment group	120	48	34	26	12	90.0%
Matched group	80	24	18	15	23	71.3%

From the above results, the present invention treats the evident in efficacy of rheumatoid arthritis Chinese medicine composition and is better than western medicine group.

Claims (3)

1. treat a Chinese medicine composition for rheumatoid arthritis, it is characterized in that, its raw material primarily of following weight portion is prepared from:

Radix Saposhnikoviae 11-33, Radix Angelicae Sinensis 11-33, Rhizoma Drynariae 5-15, Fructus Psoraleae 3-12, Herba Epimedii 3-12, Scorpio 3-12, Radix Dipsaci 3-12, Rhizoma Zingiberis 3-12, Radix Astragali 1-6, Radix Glycyrrhizae 11-33.

2. the Chinese medicine composition for the treatment of rheumatoid arthritis as claimed in claim 1, it is characterized in that, the raw material primarily of following weight portion is prepared from:

Radix Saposhnikoviae 24, Radix Angelicae Sinensis 24, Rhizoma Drynariae 10, Fructus Psoraleae 6, Herba Epimedii 6, Scorpio 4, Radix Dipsaci 4, Rhizoma Zingiberis 6, the Radix Astragali 3, Radix Glycyrrhizae 18.

3. the Chinese medicine composition for the treatment of rheumatoid arthritis as claimed in claim 1 or 2, it is characterized in that, its preparation method, concrete steps are as follows:

1) take each traditional Chinese medicinal material raw materials by proportioning, then put into Chinese medicine grinder respectively and pulverize, grinding and sieving;

2) fine drug powder of the Radix Saposhnikoviae of step 1) being prepared, Radix Angelicae Sinensis, Rhizoma Drynariae, Fructus Psoraleae, Rhizoma Zingiberis, the Radix Astragali, Radix Glycyrrhizae adds in container, adds the dehydrated alcohol of 6-10 times amount, reflux, extract, 1-3 hour, collects extracting solution after cooling;

3) toward step 2) add the water of 3-6 times amount in gained medicinal residues, reflux, extract, 1-4 hour, collects extracting solution after cooling;

4) merge the extracting solution of twice, leave standstill and obtain supernatant; It is the thick paste of 1.10-1.20 that supernatant heating is concentrated into relative density at 60 DEG C;

5) in thick paste, add the fine drug powder of Herba Epimedii, Scorpio, Radix Dipsaci, drying obtains dry extract;

6) carried out by dry extract pulverizing, sieving, add adjuvant, mixing, makes required dosage form according to a conventional method.