CN104491774A - Medicine for treating chronic diarrhea and preparation method of medicine - Google Patents
Medicine for treating chronic diarrhea and preparation method of medicine Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A61K35/56—Materials from animals other than mammals
- A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/282—Organic compounds, e.g. fats
- A61K9/2826—Sugars or sugar alcohols, e.g. sucrose; Derivatives thereof
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention discloses a medicine for treating chronic diarrhea and a preparation method of the medicine. The medicine is prepared from atractylodes macrocephala koidz, rhizoma zingiberis, endothelium corneum gigeriae galli, cooked jujube flesh, Chinese yam and longan pulp combined at a certain ratio. The traditional Chinese medicine composition disclosed by the invention is capable of tonifyign the spleen, checking diarrhea, recuperating insufficiency of the spleen under medical treatment, warmly invigorating the spleen and stomach, invigorating qi and blood, and treating insufficiency of the spleen and reduced appetite and abdominal distention diarrhea, has an accurate curative effect on treatment of the chronic diarrhea, and is free of a toxic or side effect.
Description
Technical field
The present invention relates to a kind of is Chinese medicine composition of crude drug and preparation method thereof by Chinese herbal medicine, relates to a kind of medicine for the treatment of chronic diarrhea and preparation method thereof specifically.
Background technology
Chronic diarrhea is a kind of common symptoms, not a kind of disease.Refer to the diarrhoea of the course of disease more than two months or the intermission recurrent diarrhoea in 2 ~ 4 weeks.The cause of disease is comparatively complicated, and the course of disease is delayed.Current western medicine is mainly with antiinflammatory, antibiotics treatment, but because chronic diarrhea pathogeny is very complicated, be difficult to symptomatic treatment, therapeutic effect is undesirable, and easily produces drug resistance, and cure rate is unsatisfactory, least very high.And Chinese medicine has and not easily produces drug resistance, Reusability is still effective, the advantage that toxic and side effects is little.Good advantage is had to the treatment by Chinese herbs for the treatment of chronic diarrhea.
Summary of the invention
The present invention, from clinical treatment medication demand and the dialectical principle of traditional Chinese medical science prescription, proposes a kind of medicine for the treatment of chronic diarrhea and preparation method thereof.It is the medicament be prepared from by the crude drug of following parts by weight proportioning: Rhizoma Atractylodis Macrocephalae 9-15g, Rhizoma Zingiberis 3-9g, Endothelium Corneum Gigeriae Galli 3-9g, ripe jujube pulp 12-18g, Rhizoma Dioscoreae 9-15g, Arillus Longan 12-18g.Optimum ratio is: Rhizoma Atractylodis Macrocephalae 12g, Rhizoma Zingiberis 6g, Endothelium Corneum Gigeriae Galli 6g, ripe jujube pulp 15g, Rhizoma Dioscoreae 12g, Arillus Longan 15g.Described medicament is decoction, capsule, tablet or pill.
The preparation method step of described capsule, tablet, pill is as follows:
(1) in the side of getting, screen analysis pulverized by the Rhizoma Atractylodis Macrocephalae, Rhizoma Zingiberis, Endothelium Corneum Gigeriae Galli, ripe jujube pulp, Rhizoma Dioscoreae, Arillus Longan;
(2) decocted with water 2-3 time by the mixture of sieve series in step (1), collecting decoction, filtration, worry liquid is condensed into 70-80 when spending, capsule, pill relative density are the thick paste of 1.0-1.6, and tablet relative density is the thick paste of 1.0-1.4;
(3) when making capsule, pill:
By thick paste separation and purification, drying, make dry granule; By dry granule mix homogeneously, in filled capsules, namely make capsule; Dry granule spray is added refined honey, mix homogeneously, makes piller and namely make pill;
When making tablet:
2-4 part starch is mixed homogeneously with the thick paste in step (2), makes granule, drying, make dry granule, dry granule is pressed into tablet, sugar coating, namely makes tablet.
Mixture described in step (2), the preferred number of times decocted with water is 2 times, and first time is 60-80 minute, and second time is 40-60 minute.
the pharmacology of medicine material medicine of the present invention is as follows:
The Rhizoma Atractylodis Macrocephalae: meridian distribution of property and flavor, bitter in the mouth, sweet, warm in nature.Return spleen, stomach warp.Function cures mainly: invigorating the spleen and benefiting QI, dampness diuretic, and hidroschesis is antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, frequent fetal movement.
Rhizoma Zingiberis: [return through] enters spleen, stomach, lung meridian.[function cures mainly] warming middle-JIAO is by cold, and recuperating depleted YANG is promoted blood circulation.Control trusted subordinate's cold type of pain, vomit and diarrhoea, cold extremities faint pulse, breath with cough for cold time, anemofrigid-damp arthralgia, yang deficiency is told, be defeated in battle, hematochezia.
Endothelium Corneum Gigeriae Galli: have and control eating accumulation, strengthening the spleen and stomach effect.Function cures mainly: food stagnation distension, and vomiting regurgitation, dysentery, infantile malnutrition, quenches one's thirst, incontinence of urine, sore throat tonsillitis, ulcerative gingivitis aphtha.
Ripe jujube pulp: there is invigorating the spleen to arrest diarrhea, effect of medical treatment diarrhea due to hypofunction of the spleen.
Rhizoma Dioscoreae: have and nourish strong, aid digestion, hold back sweating due to debility, effect of antidiarrheal, cure mainly insufficiency of the spleen diarrhoea, cough due to deficiency of the lung, diabetes are quenched one's thirst, oliguria frequently, seminal emission, women's leukorrhagia and dyspeptic chronic enteritis.
Arillus Longan: have warming and invigorating the spleen and stomach, vigorate qi and replenish the blood, antibacterial blood fat reducing, effect of tranquilizing the mind, controls diarrhea due to hypofunction of the spleen.
The present invention is with ripe jujube pulp, Arillus Longan for monarch drug, and invigorating the spleen to arrest diarrhea, recuperates under medical treatment insufficiency of the spleen, warming and invigorating the spleen and stomach, vigorate qi and replenish the blood, antibacterial blood fat reducing, tranquilizing the mind.With the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae for ministerial drug, invigorating the spleen and benefiting QI, dampness diuretic, nourishes strong, aid digestion, holds back sweating due to debility, antidiarrheal, and insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels.Assistant makes, with Rhizoma Zingiberis, Endothelium Corneum Gigeriae Galli, to control trusted subordinate's cold type of pain, vomits and diarrhoea, eating accumulation, strengthening the spleen and stomach.Medicine of the present invention holds the marrow of the traditional Chinese medical science, rigorous prescription, and all medicine monarch share, and mends broken combination, brings out the best in each other, meet the principle of traditional Chinese medical science medicine law and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs.
beneficial effect
Chinese medicine composition of the present invention can invigorating the spleen to arrest diarrhea, and recuperate under medical treatment insufficiency of the spleen, warming and invigorating the spleen and stomach, vigorate qi and replenish the blood, control insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, and has practical curative effect, and have no side effect to treatment chronic diarrhea.
non-clinical statistical data
1, case screening
2012-2013 Chronic Diarrhea Patients 67 example.Wherein, male 29 example, women 38 example, the age 21-65 year between, disease makes between 2 months to 6 years.Wherein ameba enteritis 7 example, chronic bacillary dysentery 17 example, Anaphylaxis enteritis 8 example, ulcerative enteritis 6 example, proctosigmoiditis 17 example, intestinal swashs syndrome 12 example.
2, diagnostic criteria
The disease cycle is longer, and more than 2 months persistent period, times of defecation is many, just rare or shapeless, sometimes accompanies mucus, pus and blood.
3, therapeutic scheme
Made capsule in embodiment 2, the morning, noon and afternoon, half an hour, respectively once each 4, every 0.3g 15 days was a course for the treatment of after meal.
4, the standard of curative effect evaluation
Cure: stool is normal, other transference cure, and Clinical Laboratory is normal;
Effective: times of defecation obviously reduces, other symptom improves;
Invalid: clinical symptoms without significant change, or increases the weight of;
Total effective rate=cure rate+effective percentage.
5, statistical result
| Case load | Cure | Effectively | Invalid | Cure rate | Total effective rate |
| 67 | 51 | 16 | 0 | 76.12% | 100.00% |
6, conclusion
67 routine Chronic Diarrhea Patients curative effects 2012-2013 being applied to the treatment of this capsule carry out the rear discovery of screening statistics, and cure 51 examples, cure rate reaches 76.12%, and effective 16 examples, total effective rate reaches 100%.
Clinical practice for many years and test, medicine of the present invention has practical curative effect to the chronic diarrhea that treatment inflammatory bowel, the infectious tuberculosis of intestine of functional irritable bowel syndrome, ameba enteropathy, chronic bacillary dysentery, fungal infection cause.
acute toxicity test:larger dose and take to the growth of rat without remarkable toxicity compared with long-term therapy, have no overt toxicity damage to the chip form inspection such as brain, the heart, liver, kidney of rat and change, test display, this drug toxicity is very little.
Detailed description of the invention
embodiment 1:a kind of medicine for the treatment of chronic diarrhea and preparation method thereof.It is the medicament be prepared from by the crude drug of following parts by weight proportioning: Rhizoma Atractylodis Macrocephalae 9-15g, Rhizoma Zingiberis 3-9g, Endothelium Corneum Gigeriae Galli 3-9g, ripe jujube pulp 12-18g, Rhizoma Dioscoreae 9-15g, Arillus Longan 12-18g.Described medicament is capsule, tablet or pill.
According to following portions by weight proportioning weighting raw materials:
Rhizoma Atractylodis Macrocephalae 9-15g, Rhizoma Zingiberis 3-9g, Endothelium Corneum Gigeriae Galli 3-9g, ripe jujube pulp 12-18g, Rhizoma Dioscoreae 9-15g, Arillus Longan 12-18g.
The preparation method step of described capsule, tablet, pill is as follows:
(1) in the side of getting, screen analysis pulverized by the Rhizoma Atractylodis Macrocephalae, Rhizoma Zingiberis, Endothelium Corneum Gigeriae Galli, ripe jujube pulp, Rhizoma Dioscoreae, Arillus Longan;
(2) decocted with water 2-3 time by the mixture of sieve series in step (1), collecting decoction, filtration, worry liquid is condensed into 70-80 when spending, capsule, pill relative density are the thick paste of 1.0-1.6, and tablet relative density is the thick paste of 1.0-1.4;
(3) when making capsule, pill:
By thick paste separation and purification, drying, make dry granule; By dry granule mix homogeneously, in filled capsules, namely make capsule; Dry granule spray is added refined honey, mix homogeneously, makes piller and namely make pill;
When making tablet:
2-4 part starch is mixed homogeneously with the thick paste in step (2), makes granule, drying, make dry granule, dry granule is pressed into tablet, sugar coating, namely makes tablet.
Mixture described in step (2), the preferred number of times decocted with water is 2 times, and first time is 60-80 minute, and second time is 40-60 minute.
embodiment 2:a kind of medicine for the treatment of chronic diarrhea and preparation method thereof.It is the medicament be prepared from by the crude drug of following parts by weight proportioning: Rhizoma Atractylodis Macrocephalae 12g, Rhizoma Zingiberis 6g, Endothelium Corneum Gigeriae Galli 6g, ripe jujube pulp 15g, Rhizoma Dioscoreae 12g, Arillus Longan 15g.Described medicament is capsule, tablet or pill.
According to following portions by weight proportioning weighting raw materials:
Rhizoma Atractylodis Macrocephalae 12g, Rhizoma Zingiberis 6g, Endothelium Corneum Gigeriae Galli 6g, ripe jujube pulp 15g, Rhizoma Dioscoreae 12g, Arillus Longan 15g.
The preparation method step of described capsule, tablet, pill is as follows:
(1) in the side of getting, screen analysis pulverized by the Rhizoma Atractylodis Macrocephalae, Rhizoma Zingiberis, Endothelium Corneum Gigeriae Galli, ripe jujube pulp, Rhizoma Dioscoreae, Arillus Longan;
(2) decocted with water 2-3 time by the mixture of sieve series in step (1), collecting decoction, filtration, worry liquid is condensed into 70-80 when spending, capsule, pill relative density are the thick paste of 1.0-1.6, and tablet relative density is the thick paste of 1.0-1.4;
(3) when making capsule, pill:
By thick paste separation and purification, drying, make dry granule; By dry granule mix homogeneously, in filled capsules, namely make capsule; Dry granule spray is added refined honey, mix homogeneously, makes piller and namely make pill;
When making tablet:
2-4 part starch is mixed homogeneously with the thick paste in step (2), makes granule, drying, make dry granule, dry granule is pressed into tablet, sugar coating, namely makes tablet.
Mixture described in step (2), the preferred number of times decocted with water is 2 times, and first time is 60-80 minute, and second time is 40-60 minute.
Embodiment 3, medicine of the present invention can also be decoction, oral liquid, granule etc.
Claims (5)
1. treat a medicine for chronic diarrhea, it is characterized in that it is the medicament be prepared from by the crude drug of following parts by weight proportioning: Rhizoma Atractylodis Macrocephalae 9-15g, Rhizoma Zingiberis 3-9g, Endothelium Corneum Gigeriae Galli 3-9g, ripe jujube pulp 12-18g, Rhizoma Dioscoreae 9-15g, Arillus Longan 12-18g.
2. the medicine for the treatment of chronic diarrhea according to claim 1, is characterized in that it is the medicament be prepared from by the crude drug of following parts by weight proportioning: Rhizoma Atractylodis Macrocephalae 12g, Rhizoma Zingiberis 6g, Endothelium Corneum Gigeriae Galli 6g, ripe jujube pulp 15g, Rhizoma Dioscoreae 12g, Arillus Longan 15g.
3. the medicine for the treatment of chronic diarrhea according to claim 1 and 2, is characterized in that: described medicament is decoction, capsule, tablet or pill.
4. the medicine for the treatment of chronic diarrhea according to claim 3, is characterized in that: the preparation method step of described capsule, tablet, pill is as follows:
(1) in the side of getting, screen analysis pulverized by the Rhizoma Atractylodis Macrocephalae, Rhizoma Zingiberis, Endothelium Corneum Gigeriae Galli, ripe jujube pulp, Rhizoma Dioscoreae, Arillus Longan;
(2) decocted with water 2-3 time by the mixture of sieve series in step (1), collecting decoction, filtration, worry liquid is condensed into 70-80 when spending, capsule, pill relative density are the thick paste of 1.0-1.6, and tablet relative density is the thick paste of 1.0-1.4;
(3) when making capsule, pill:
By thick paste separation and purification, drying, make dry granule; By dry granule mix homogeneously, in filled capsules, namely make capsule; Dry granule spray is added refined honey, mix homogeneously, makes piller and namely make pill;
When making tablet:
2-4 part starch is mixed homogeneously with the thick paste in step (2), makes granule, drying, make dry granule, dry granule is pressed into tablet, sugar coating, namely makes tablet.
5. the preparation method of the medicine for the treatment of chronic diarrhea according to claim 4, is characterized in that the mixture described in step (2), and the number of times decocted with water is 2 times, and first time is 60-80 minute, and second time is 40-60 minute.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410703951.5A CN104491774A (en) | 2014-11-30 | 2014-11-30 | Medicine for treating chronic diarrhea and preparation method of medicine |
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| CN201410703951.5A CN104491774A (en) | 2014-11-30 | 2014-11-30 | Medicine for treating chronic diarrhea and preparation method of medicine |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106267047A (en) * | 2015-05-15 | 2017-01-04 | 王世祥 | A kind of Chinese medicine formula treating diarrhoea |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1915418A (en) * | 2006-08-25 | 2007-02-21 | 胡国良 | Medication of medical broth for treating disease of wean alvine flux, and preparation method |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1915418A (en) * | 2006-08-25 | 2007-02-21 | 胡国良 | Medication of medical broth for treating disease of wean alvine flux, and preparation method |
Non-Patent Citations (2)
| Title |
|---|
| 周阿高: "《中医学》", 31 January 2012, 上海科学技术出版社 * |
| 张锡纯: "《医学衷中参西录》", 31 January 2009, 山西科学技术出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106267047A (en) * | 2015-05-15 | 2017-01-04 | 王世祥 | A kind of Chinese medicine formula treating diarrhoea |
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Application publication date: 20150408 |