CN104491502A - Medicament for treating spontaneous perspiration and preparation method thereof - Google Patents
Medicament for treating spontaneous perspiration and preparation method thereof Download PDFInfo
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/17—Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/481—Astragalus (milkvetch)
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Abstract
The invention discloses a medicament for treating spontaneous perspiration and a preparation method thereof. The medicament is prepared from oyster, milkvetch root, divaricate saposhnikovia root, blighted wheat, ephedra root, common macrocarpium fruit and largehead atractylodes rhizome according to certain proportions by virtue of combination. The traditional Chinese medicine composition disclosed by the invention has effects of strengthening the spleen and replenishing qi, strengthening the liver for detoxification, purifying blood stasis, recovering fatigue and astringing to consolidate depletion, has a good curative effect on spontaneous perspiration and night sweats, and does not have toxic or side effects.
Description
Technical field
The present invention relates to a kind of is Chinese medicine composition of crude drug and preparation method thereof by Chinese herbal medicine, relates to a kind of medicine for the treatment of spontaneous perspiration and preparation method thereof specifically.
Background technology
Spontaneous perspiration, be one not because of tired movable, not because of sky heat and warm performance of taking factors such as dispersing medicine and natural sweating of wearing the clothes.How because feel frustrated the moon, deficiency of vital energy yang deficiency etc. of disharmony of nutrient QI with defensive QI, extreme heat in YANG MING, summer-heat causes, be found in diseases caused by exogenous pathogenic factor six climate exopathogens or miscellaneous diseases caused by endogenous pathogens, the former mostly is excess syndrome, and the latter mostly is deficiency syndrome.
The how main void of disease of spontaneous perspiration, has that the deficiency of vital energy, yang deficiency are not, main pathogenesis is imbalance of YIN and YANG, and space between skin and muscles is solid, and causes perspiration and leak.Ferritic is weak, the people of the full void of prolonged illness, and positive QI-insufficiency, pauses tired common spontaneous perspiration; Cough with asthma day Sheng people, insufficiency of lung-QI, with the passing of time, loose striac of the skin and muscles, instability of surface, space between skin and muscles using pungent drugs for dispersion and bitter drugs for purgation can cause spontaneous perspiration to the deficiency of vital energy.Summer-heat impairment of YANG, or damp and hot interior strongly fragrant, or the people of exterior deficiency is micro-by ailment said due to cold or exposure, so that disharmony of nutrient QI with defensive QI, defend outer mistake department, can spontaneous perspiration be caused.
Summary of the invention
The present invention, from clinical treatment medication demand and the dialectical principle of traditional Chinese medical science prescription, proposes a kind of medicine for the treatment of spontaneous perspiration and preparation method thereof.It is the medicament be prepared from by the crude drug of following parts by weight proportioning: Concha Ostreae 16-24, Radix Astragali 8-16g, Radix Saposhnikoviae 8-16g, Fructus Tritici Levis 8-16g, Radix Ephedrae 6-14g, Fructus Corni 6-14g, Rhizoma Atractylodis Macrocephalae 6-14g.Optimum ratio is: Concha Ostreae 20g, Radix Astragali 12g, Radix Saposhnikoviae 12g, Fructus Tritici Levis 12g, Radix Ephedrae 10g, Fructus Corni 10g, Rhizoma Atractylodis Macrocephalae 10g.Described medicament is decoction, capsule, tablet or pill.
The preparation method step of described capsule, tablet, pill is as follows:
(1) in the side of getting, screen analysis pulverized by Concha Ostreae, the Radix Astragali, Radix Saposhnikoviae, Fructus Tritici Levis, Radix Ephedrae, Fructus Corni, the Rhizoma Atractylodis Macrocephalae;
(2) decocted with water 2-3 time by the mixture of sieve series in step (1), collecting decoction, filtration, worry liquid is condensed into 70-80 when spending, capsule, pill relative density are the thick paste of 1.0-1.6, and tablet relative density is the thick paste of 1.0-1.4;
(3) when making capsule, pill:
By thick paste separation and purification, drying, make dry granule; By dry granule mix homogeneously, in filled capsules, namely make capsule; Dry granule spray is added refined honey, mix homogeneously, makes piller and namely make pill;
When making tablet:
2-4 part starch is mixed homogeneously with the thick paste in step (2), makes granule, drying, make dry granule, dry granule is pressed into tablet, sugar coating, namely makes tablet.
Mixture described in step (2), the preferred number of times decocted with water is 2 times, and first time is 60-80 minute, and second time is 40-60 minute.
the pharmacology of medicine material medicine of the present invention is as follows:
Concha Ostreae: Concha Ostreae is that (every 100g zinc content 9.39mg, is rich in one of food being rich in zinc element
protein-zinc), belong to Ostreidae (the true Concha Ostreae of Ostreidae) or Yan Ha section (Aviculidae pearl oyster), bivalve, is distributed in each ocean in temperate zone and the torrid zone stretch of coastal water.Modern medicine thinks that Concha Ostreae has seven large effects: 1, liver-invigorating detoxication; 2, sexual function is improved; 3, congestion purification; 4, set up; 5, appearance skin care is grown; 6, immunity is improved; 7, enhance metabolism.Cure mainly: spontaneous perspiration, night sweat.Cure mainly: all cards of slippage, can treat spontaneous perspiration, night sweat by different compatibility, seminal emission, spermatorrhea, frequent micturition, the enuresis, metrorrhagia, is with the card of inferior slippage.
Fructus Tritici Levis: function cures mainly: except deficiency-heat, hidroschesis.Main only fever due to yin deficiency, night sweat, spontaneous perspiration.
Radix Ephedrae: cure mainly spontaneous perspiration due to yang insufficiency, night sweat due to yin deficiency.
The Radix Astragali: have enhancing human body immunity function, protect the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely, cure mainly exterior deficiency spontaneous perspiration, night sweat due to yin deficiency.
Radix Saposhnikoviae: Gui Jing: urinary bladder channel; Lung meridian; Spleen channel; Liver Channel.Effect: expelling pathogenic wind from the body surface, removing dampness to relieve pain, spasmolytic, antipruritic, cures mainly affection of exogenous wind-cold, headache general pain, rheumatic arthralgia, joint is ached, stomachache is had loose bowels, discharging fresh blood stool, tetanus, rubella pruritus.
Fructus Corni: liver and kidney tonifying; Convergence is solid de-.Main waist is had a dizzy spell; Deafness and tinnitus; Soreness of the waist and knees; Xian essence spermatorrhea; Frequent micturition; Incessant sweating due to debility; Woman uterine bleeding; Interior-heat is quenched one's thirst; Warming the liver the kidney invigorating, except a wind cutting, only menorrhagia, controls senile frequent micturition.
The Rhizoma Atractylodis Macrocephalae: have invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect, for insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement." medicine origin " is recorded: dehumidifying benefit is dry, and middle QI invigorating, warming middle-JIAO, and go in taste wet, except gastric heat, strong taste, enter diet, antiabortive.
The present invention take Concha Ostreae as monarch drug, liver-invigorating detoxication, and purification congestion, sets up, the card for the treatment of slippage, spontaneous sweating.With Fructus Tritici Levis, Radix Ephedrae, Radix Saposhnikoviae for ministerial drug, expelling pathogenic wind from the body surface, removing dampness to relieve pain, except deficiency-heat, only spontaneous perspiration, only fever due to yin deficiency, only night sweat.Assistant makes with the Radix Astragali, Fructus Corni, the Rhizoma Atractylodis Macrocephalae, enhancing human body immunity function, protect the liver, diuresis, anti-stress, blood pressure lowering, liver and kidney tonifying, convergence is solid de-, and invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis is antiabortive.Medicine of the present invention holds the marrow of the traditional Chinese medical science, rigorous prescription, and all medicine monarch share, and mends broken combination, brings out the best in each other, meet the principle of traditional Chinese medical science medicine law and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs.
beneficial effect
Chinese medicine composition energy of the present invention invigorating the spleen and benefiting QI, liver-invigorating detoxication, purification congestion, sets up, and convergence is solid de-, has good therapeutic effect, and have no side effect to treatment spontaneous sweating.
clinical testing data:
The drug effect of medicine for a better understanding of the present invention, is now summarized as follows clinical data:
1, case load: 2011-2013, clinical treatment spontaneous perspiration patient 371 example, man 165 example, female 106 example, age 13-67 year.
2, spontaneous perspiration symptom: have a headache and fever, perspiration and aversion to wind, dynamic then easily very or half body is perspired, or perspires in local, and aching of the whole body, easily catches a cold, fatigue and asthenia, if white and thin fur, thready pulse.
3, therapeutic scheme: take the made capsule of the embodiment of the present invention 2, the morning, noon and afternoon, respectively once each 4, every 0.3g, under warm water clothes, 15 days was a course for the treatment of.
4, the standard of curative effect evaluation:
Cure: clinical symptoms all disappears, and whole body, without any discomfort, does not recur in half a year;
Effective: spontaneous perspiration cardinal symptom obviously alleviates, nervous weak, micro-perspiration sometimes after activity;
Invalid: spontaneous perspiration symptom variation is very micro-, or increases the weight of;
Total effective rate=cure rate+effective percentage.
5, statistical result
After 1 course for the treatment of, cure 301 examples, cure rate reaches 81.13%.Effective 63 examples, invalid 7 examples, total effective rate reaches 98.11%.
6, conclusion
Medicine of the present invention has significant curative effect to treatment deficiency syndrome spontaneous perspiration.
acute toxicity test:larger dose and take to the growth of rat without remarkable toxicity compared with long-term therapy, have no overt toxicity damage to the chip form inspection such as brain, the heart, liver, kidney of rat and change, test display, this drug toxicity is very little.
Detailed description of the invention
embodiment 1:a kind of medicine for the treatment of spontaneous perspiration and preparation method thereof.It is the medicament be prepared from by the crude drug of following parts by weight proportioning: Concha Ostreae 16-24, Radix Astragali 8-16g, Radix Saposhnikoviae 8-16g, Fructus Tritici Levis 8-16g, Radix Ephedrae 6-14g, Fructus Corni 6-14g, Rhizoma Atractylodis Macrocephalae 6-14g.Described medicament is capsule, tablet or pill.
According to following portions by weight proportioning weighting raw materials:
Concha Ostreae 16-24, Radix Astragali 8-16g, Radix Saposhnikoviae 8-16g, Fructus Tritici Levis 8-16g, Radix Ephedrae 6-14g, Fructus Corni 6-14g, Rhizoma Atractylodis Macrocephalae 6-14g.
The preparation method step of described capsule, tablet, pill is as follows:
(1) in the side of getting, screen analysis pulverized by Concha Ostreae, the Radix Astragali, Radix Saposhnikoviae, Fructus Tritici Levis, Radix Ephedrae, Fructus Corni, the Rhizoma Atractylodis Macrocephalae;
(2) decocted with water 2-3 time by the mixture of sieve series in step (1), collecting decoction, filtration, worry liquid is condensed into 70-80 when spending, capsule, pill relative density are the thick paste of 1.0-1.6, and tablet relative density is the thick paste of 1.0-1.4;
(3) when making capsule, pill:
By thick paste separation and purification, drying, make dry granule; By dry granule mix homogeneously, in filled capsules, namely make capsule; Dry granule spray is added refined honey, mix homogeneously, makes piller and namely make pill;
When making tablet:
2-4 part starch is mixed homogeneously with the thick paste in step (2), makes granule, drying, make dry granule, dry granule is pressed into tablet, sugar coating, namely makes tablet.
Mixture described in step (2), the preferred number of times decocted with water is 2 times, and first time is 60-80 minute, and second time is 40-60 minute.
embodiment 2:a kind of medicine for the treatment of spontaneous perspiration and preparation method thereof.It is the medicament be prepared from by the crude drug of following parts by weight proportioning: Concha Ostreae 20g, Radix Astragali 12g, Radix Saposhnikoviae 12g, Fructus Tritici Levis 12g, Radix Ephedrae 10g, Fructus Corni 10g, Rhizoma Atractylodis Macrocephalae 10g.Described medicament is capsule, tablet or pill.
According to following portions by weight proportioning weighting raw materials:
Concha Ostreae 20g, Radix Astragali 12g, Radix Saposhnikoviae 12g, Fructus Tritici Levis 12g, Radix Ephedrae 10g, Fructus Corni 10g, Rhizoma Atractylodis Macrocephalae 10g.
The preparation method step of described capsule, tablet, pill is as follows:
(1) in the side of getting, screen analysis pulverized by Concha Ostreae, the Radix Astragali, Radix Saposhnikoviae, Fructus Tritici Levis, Radix Ephedrae, Fructus Corni, the Rhizoma Atractylodis Macrocephalae;
(2) decocted with water 2-3 time by the mixture of sieve series in step (1), collecting decoction, filtration, worry liquid is condensed into 70-80 when spending, capsule, pill relative density are the thick paste of 1.0-1.6, and tablet relative density is the thick paste of 1.0-1.4;
(3) when making capsule, pill:
By thick paste separation and purification, drying, make dry granule; By dry granule mix homogeneously, in filled capsules, namely make capsule; Dry granule spray is added refined honey, mix homogeneously, makes piller and namely make pill;
When making tablet:
2-4 part starch is mixed homogeneously with the thick paste in step (2), makes granule, drying, make dry granule, dry granule is pressed into tablet, sugar coating, namely makes tablet.
Mixture described in step (2), the preferred number of times decocted with water is 2 times, and first time is 60-80 minute, and second time is 40-60 minute.
embodiment 3:medicine of the present invention can also be decoction, oral liquid, granule etc.
Claims (5)
1. treat a medicine for spontaneous perspiration, it is characterized in that it is the medicament be prepared from by the crude drug of following parts by weight proportioning: Concha Ostreae 16-24, Radix Astragali 8-16g, Radix Saposhnikoviae 8-16g, Fructus Tritici Levis 8-16g, Radix Ephedrae 6-14g, Fructus Corni 6-14g, Rhizoma Atractylodis Macrocephalae 6-14g.
2. the medicine for the treatment of spontaneous perspiration according to claim 1, is characterized in that it is the medicament be prepared from by the crude drug of following parts by weight proportioning: Concha Ostreae 20g, Radix Astragali 12g, Radix Saposhnikoviae 12g, Fructus Tritici Levis 12g, Radix Ephedrae 10g, Fructus Corni 10g, Rhizoma Atractylodis Macrocephalae 10g.
3. the medicine for the treatment of spontaneous perspiration according to claim 1 and 2, is characterized in that: described medicament is decoction, capsule, tablet or pill.
4. the medicine for the treatment of spontaneous perspiration according to claim 3, is characterized in that: the preparation method step of described capsule, tablet, pill is as follows:
(1) in the side of getting, screen analysis pulverized by Concha Ostreae, the Radix Astragali, Radix Saposhnikoviae, Fructus Tritici Levis, Radix Ephedrae, Fructus Corni, the Rhizoma Atractylodis Macrocephalae;
(2) decocted with water 2-3 time by the mixture of sieve series in step (1), collecting decoction, filtration, worry liquid is condensed into 70-80 when spending, capsule, pill relative density are the thick paste of 1.0-1.6, and tablet relative density is the thick paste of 1.0-1.4;
(3) when making capsule, pill:
By thick paste separation and purification, drying, make dry granule; By dry granule mix homogeneously, in filled capsules, namely make capsule; Dry granule spray is added refined honey, mix homogeneously, makes piller and namely make pill;
When making tablet:
2-4 part starch is mixed homogeneously with the thick paste in step (2), makes granule, drying, make dry granule, dry granule is pressed into tablet, sugar coating, namely makes tablet.
5. the preparation method of the medicine for the treatment of spontaneous perspiration according to claim 4, is characterized in that the mixture described in step (2), and the number of times decocted with water is 2 times, and first time is 60-80 minute, and second time is 40-60 minute.
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