CN104491590A - Health-care tea used for gastroesophageal reflux cough - Google Patents
Health-care tea used for gastroesophageal reflux cough Download PDFInfo
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- CN104491590A CN104491590A CN201410689339.7A CN201410689339A CN104491590A CN 104491590 A CN104491590 A CN 104491590A CN 201410689339 A CN201410689339 A CN 201410689339A CN 104491590 A CN104491590 A CN 104491590A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
- A23F3/00—Tea; Tea substitutes; Preparations thereof
- A23F3/34—Tea substitutes, e.g. matè; Extracts or infusions thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/738—Rosa (rose)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8994—Coix (Job's tears)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8998—Hordeum (barley)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
Abstract
The invention belongs to the technical field of medicines, and concretely relates to health-care tea used for gastroesophageal reflux cough. The health-care tea used for gastroesophageal reflux cough is composed of the following bulk drugs in parts by weight: 1-5 parts of radix glycyrrhizae, 1-5 parts of semen coicis, 1-5 parts of bitter apricot seed, 1-5 parts of rhizoma phragmitis, 1-5 parts of flos rosae rugosae, 1-5 parts of flos chrysanthemi, 1-5 parts of jasminum sambac, 1-5 parts of flos lonicerae, 1-5 parts of medicated leaven, 1-5 parts of fructus hordei germinatus, and 1-5 parts of fructus crataegi. When 60 examples in a treatment group and 60 examples in a contrast group finish a treatment course by using the health-care tea used for gastroesophageal reflux cough, the clinic total obvious effective rate of treating gastroesophageal reflux cough in the treatment group is 78.33%, and the total obvious effective rate of treating gastroesophageal reflux cough in the contrast group is 43.33%, difference and statistical significance are generated between the two groups (P<0.05).
Description
Technical field
The invention belongs to medical art, be specifically related to a kind of health tea for gastroesophageal reflux induced cough.
Background technology
Be that the gastroesophageal reflux disease of main clinical manifestation is called gastroesophageal reflux induced cough (GERC) with chronic cough, there is research display, the gastroesophageal reflux induced cough exceeding half all lacks gastrointestinal symptom, only show as repeatedly difficult cough of healing, very easily obscure with respiratory system and Throat diseases, because more neural reflex is participated, make the gastroesophageal reflux induced cough breach of finding treatment more difficult compared with gastroesophageal reflux disease, go back the therapeutic scheme of neither one the best so far.Not yet there is the medicine being exclusively used in primary disease at present.
Summary of the invention
In order to solve above-mentioned technical problem, the invention provides a kind of health tea for gastroesophageal reflux induced cough and application thereof.
The present invention is realized by following technical scheme:
For a health tea for gastroesophageal reflux induced cough, be made up of the crude drug of following weight: Radix Glycyrrhizae 1-5 part, Semen Coicis 1-5 part, Semen Armeniacae Amarum 1-5 part, Rhizoma Phragmitis 1-5 part, Flos Rosae Rugosae 1-5 part, Flos Chrysanthemi 1-5 part, Flos Jasmini Sambac 1-5 part, Flos Lonicerae 1-5 part, Massa Medicata Fermentata 1-5 part, Fructus Hordei Germinatus 1-5 part, Fructus Crataegi 1-5 part.
Preferably, the above-mentioned health tea for gastroesophageal reflux induced cough, is made up of the crude drug of following weight: Radix Glycyrrhizae 2-4 part, Semen Coicis 2-4 part, Semen Armeniacae Amarum 2-4 part, Rhizoma Phragmitis 2-4 part, Flos Rosae Rugosae 2-4 part, Flos Chrysanthemi 2-4 part, Flos Jasmini Sambac 2-4 part, Flos Lonicerae 2-4 part, Massa Medicata Fermentata 2-4 part, Fructus Hordei Germinatus 2-4 part, Fructus Crataegi 2-4 part.
Preferred, the above-mentioned health tea for gastroesophageal reflux induced cough, is made up of the crude drug of following weight: 3 parts, Radix Glycyrrhizae, Semen Coicis 3 parts, 3 parts, Semen Armeniacae Amarum, Rhizoma Phragmitis 3 parts, Flos Rosae Rugosae 3 parts, Flos Chrysanthemi 3 parts, Flos Jasmini Sambac 3 parts, Flos Lonicerae 3 parts, Massa Medicata Fermentata 3 parts, 3 parts, Fructus Hordei Germinatus, Fructus Crataegi 3 parts.
Preferably, the above-mentioned health tea for gastroesophageal reflux induced cough, is made up of the crude drug of following weight:
1 part, Radix Glycyrrhizae, Semen Coicis 5 parts, 1 part, Semen Armeniacae Amarum, Rhizoma Phragmitis 5 parts, Flos Rosae Rugosae 1 part, Flos Chrysanthemi 5 parts, Flos Jasmini Sambac 1 part, Flos Lonicerae 5 parts, Massa Medicata Fermentata 1 part, 5 parts, Fructus Hordei Germinatus, Fructus Crataegi 1 part.
Preferably, the above-mentioned health tea for gastroesophageal reflux induced cough, is made up of the crude drug of following weight:
5 parts, Radix Glycyrrhizae, Semen Coicis 1 part, 5 parts, Semen Armeniacae Amarum, Rhizoma Phragmitis 1 part, Flos Rosae Rugosae 5 parts, Flos Chrysanthemi 1 part, Flos Jasmini Sambac 5 parts, Flos Lonicerae 1 part, Massa Medicata Fermentata 5 parts, 1 part, Fructus Hordei Germinatus, Fructus Crataegi 5 parts.
Preferred, the above-mentioned health tea for gastroesophageal reflux induced cough, is made up of the crude drug of following weight: 2 parts, Radix Glycyrrhizae, Semen Coicis 4 parts, 2 parts, Semen Armeniacae Amarum, Rhizoma Phragmitis 4 parts, Flos Rosae Rugosae 2 parts, Flos Chrysanthemi 4 parts, Flos Jasmini Sambac 2 parts, Flos Lonicerae 4 parts, Massa Medicata Fermentata 2 parts, 4 parts, Fructus Hordei Germinatus, Fructus Crataegi 2 parts.
Preferred, the above-mentioned health tea for gastroesophageal reflux induced cough, is made up of the crude drug of following weight: 4 parts, Radix Glycyrrhizae, Semen Coicis 2 parts, 4 parts, Semen Armeniacae Amarum, Rhizoma Phragmitis 2 parts, Flos Rosae Rugosae 4 parts, Flos Chrysanthemi 2 parts, Flos Jasmini Sambac 4 parts, Flos Lonicerae 2 parts, Massa Medicata Fermentata 4 parts, 2 parts, Fructus Hordei Germinatus, Fructus Crataegi 4 parts.
The application of the above-mentioned health tea for gastroesophageal reflux induced cough in the medicine of preparation treatment gastroesophageal reflux induced cough.
The manufacture method of the health tea for gastroesophageal reflux induced cough of the present invention: according to said components proportioning, mixing, with the dosage subpackage of every bag of 30-70g, point pack adopts the membrane filter paper bag of food stage.
Drinking method: be placed in thermos cup by packed above-mentioned preparation, add boiled water, adds a cover rear placement 5-10 minute, namely drinkable, drunk follow-up enter boiled water, add a cover place within 5-10 minute, drink again, so move in circles, 1-2 agent every day, each 1-2 bag.Or be decocted in water for oral dose, 1-2 agent every day, each 1-2 bag.
Modern's life stress is large, easy depression and stagnation of QI, strongly fragrantly and obstructed causes gastroesophageal reflux induced cough.This thinking is set out, and Semen Coicis spleen invigorating eliminating dampness by diuresis, controls and help it to rise at spleen; Massa Medicata Fermentata, Fructus Hordei Germinatus, Fructus Crataegi is aid digestion, helps gastric qi to fall; Radix Glycyrrhizae and in, control at taste, help it to be elevated.The five tastes and conjunction and nurse one's health the taste day after tomorrow, help its source of generating QI and blood, evil with Fuzheng Yiliu.Flos Rosae Rugosae, Flos Jasmini Sambac, enter blood system, and soothing the liver liter falls into, and holds concurrently with flat gallbladder.Rhizoma Phragmitis, Semen Armeniacae Amarum, enter edema caused by disorder of QI, and lung heat clearing is regulated the flow of vital energy, eliminating phlegm and lowering adverse QI.Qi-movement disturbance easily causes interior heat localization, adopts Flos Chrysanthemi removing heat from the liver, Flos Lonicerae lung heat clearing gastric heat, all medicines share, and play invigorating the spleen and relieving depression of liver-QI altogether, fall purgation merit in lung stomach, mediation clearly, then stomach falls and is apt to receive, spleen rises and kind mill, liver rises and blood is not strongly fragrant, and lung falls and gas is not stagnant, and heart kidney therefore hands over Thailand, the mechanism of qi of all internal organs disorders, thus again its lifting is normal, and mechanism of qi is stasis no longer, makes gastroesophageal reflux induced cough can spontaneous recovery.For gastroesophageal reflux induced cough.
Compared with prior art, the invention provides a kind of health tea prescription for gastroesophageal reflux induced cough completely newly, this prescription is from orderly and clearly the five internal organs mechanism of qi, the theory strengthening gastrointestinal function is set out, human body self gastrointestinal function is strengthened, and gastrointestinal tract is usual, gastroesophageal reflux induced cough spontaneous recovery.Health tea for gastroesophageal reflux induced cough of the present invention is pure Chinese medicinal preparation, and safety has no side effect, without drug dependence.Health tea for gastroesophageal reflux induced cough of the present invention, treatment group and matched group complete each 60 examples course for the treatment of, the Clinical Global obvious effective rate for the treatment of group treatment gastroesophageal reflux induced cough is 78.33%, matched group is 43.33%, and both are more variant statistical significance (P < 0.05).Treatment group has statistical significance (P < 0.05) improving in the cough of gastroesophageal reflux induced cough patient, belch symptom with matched group comparing difference; Two groups are compared improving in the acid regurgitation of gastroesophageal reflux induced cough patient, heartburn symptom, result difference not statistically significant (P > 0.05), health tea for gastroesophageal reflux induced cough of the present invention can effectively improve gastroesophageal reflux induced cough patient clinical symptoms, and omeprazole is better than to the curative effect of cough, belch symptom, point out the anti-reflux aspect of the health tea for gastroesophageal reflux induced cough of the present invention advantage remarkable.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.
Embodiment 1
For a health tea for gastroesophageal reflux induced cough, be made up of the crude drug of following weight:
Radix Glycyrrhizae 3g, Semen Coicis 3g, Semen Armeniacae Amarum 3g, Rhizoma Phragmitis 3g, Flos Rosae Rugosae 3g, Flos Chrysanthemi 3g, Flos Jasmini Sambac 3g, Flos Lonicerae 3g, Massa Medicata Fermentata 3g, Fructus Hordei Germinatus 3g, Fructus Crataegi 3g.
According to said components proportioning, mixing, as 1 bag or 1 dose, drinking method: packed above-mentioned preparation is placed in thermos cup, add boiled water, add a cover rear placement 5-10 minute, namely drinkable, drunk follow-up enter boiled water, add a cover to place and drink again for 5-10 minute, so move in circles, 1-2 agent every day, each 1-2 bag.Or be decocted in water for oral dose, 1-2 agent every day, each 1-2 bag.
Embodiment 2
For a health tea for gastroesophageal reflux induced cough, be made up of the crude drug of following weight:
Radix Glycyrrhizae 2g, Semen Coicis 4g, Semen Armeniacae Amarum 2g, Rhizoma Phragmitis 4g, Flos Rosae Rugosae 2g, Flos Chrysanthemi 4g, Flos Jasmini Sambac 2g, Flos Lonicerae 4g, Massa Medicata Fermentata 2g, Fructus Hordei Germinatus 4g, Fructus Crataegi 2g.
Preparation and application is with embodiment 1.
Embodiment 3
For a health tea for gastroesophageal reflux induced cough, be made up of the crude drug of following weight:
Radix Glycyrrhizae 4g, Semen Coicis 2g, Semen Armeniacae Amarum 4g, Rhizoma Phragmitis 2g, Flos Rosae Rugosae 4g, Flos Chrysanthemi 2g, Flos Jasmini Sambac 4g, Flos Lonicerae 2g, Massa Medicata Fermentata 4g, Fructus Hordei Germinatus 2g, Fructus Crataegi 4g.
Preparation and application is with embodiment 1.
Embodiment 4
For a health tea for gastroesophageal reflux induced cough, be made up of the crude drug of following weight:
Radix Glycyrrhizae 5g, Semen Coicis 1g, Semen Armeniacae Amarum 5g, Rhizoma Phragmitis 1g, Flos Rosae Rugosae 5g, Flos Chrysanthemi 1g, Flos Jasmini Sambac 5g, Flos Lonicerae 1g, Massa Medicata Fermentata 5g, Fructus Hordei Germinatus 1g, Fructus Crataegi 5g.
Preparation and application is with embodiment 1.
Embodiment 5
For a health tea for gastroesophageal reflux induced cough, be made up of the crude drug of following weight:
Radix Glycyrrhizae 1g, Semen Coicis 5g, Semen Armeniacae Amarum 1g, Rhizoma Phragmitis 5g, Flos Rosae Rugosae 1g, Flos Chrysanthemi 5g, Flos Jasmini Sambac 1g, Flos Lonicerae 5g, Massa Medicata Fermentata 1g, Fructus Hordei Germinatus 5g, Fructus Crataegi 1g.
Preparation and application is with embodiment 1.
The health tea being used for gastroesophageal reflux induced cough of the embodiment of the present invention 1 has been carried out clinical trial, and Details as Follows:
1 object and method
1.1 object
126 routine cases, adopt Randomized controlled clinical study method, adopt random digits table at random patient to be divided into treatment group and matched group in the ratio of 1:1.Because not completing 3 examples that respectively come off the course for the treatment of two groups, therefore treatment group effective case 60 example, matched group 60 example. treatment group male 19 example, women 41 example, 55 years old mean age, the most elder of the course of disease 28 months, the shortest person 4 months; Matched group male 19 people, women 41 people, 54 years old mean age, the most elder of the course of disease 36 months, the shortest person 3 months.Two groups of equal not statistically significants of comparing difference (P > 0.05) in sex ratio, age distribution, course of disease length, have comparability.
1.2 inclusive criteria
(1) " Chinese gastroesophageal reflux disease National Consensus " (2006 is met, Sanya) the tcm diagnosis standard of gastroesophageal reflux disease Western medicine diagnose standard and " Gastroesphageal Reflux Disease Treated by Chinese Medicine National Consensus " (2009, Shenzhen) acid regurgitation disease; (2) cough to choke and be chief complaint or cardinal symptom; (3) diagnostic classification standard under reflux esophagitis scope is met; (4) age is in 18-70 one full year of life, and sex is without particular restriction.
1.3 exclusion standard
(1) other digestive system disease person is merged; (2) merge other to cause and cough disease patient; (3) gastroesophageal reflux induced cough is diagnosed as but without cough person; (4) severe cardiovascular disease, hepatic and kidney function obstacle person; (5) abdominal operation, gestation and psychotic.Above any person is had to get rid of.
1.4 Therapeutic Method
Treatment group gives the health tea of the embodiment of the present invention 1 gastroesophageal reflux induced cough, prescription: Radix Glycyrrhizae 3g, Semen Coicis 3g, Semen Armeniacae Amarum 3g, Rhizoma Phragmitis 3g, Flos Rosae Rugosae 3g, Flos Chrysanthemi 3g, Flos Jasmini Sambac 3g, Flos Lonicerae 3g, Massa Medicata Fermentata 3g, Fructus Hordei Germinatus 3g, Fructus Crataegi 3g.According to said components proportioning, mixing, as 1 bag or 1 dose, drinking method: packed above-mentioned preparation is placed in thermos cup, add boiled water, add a cover rear placement 5-10 minute, namely drinkable, drunk follow-up enter boiled water, add a cover to place and drink again for 5-10 minute, so move in circles, 1-2 agent every day, each 1-2 bag.Or be decocted in water for oral dose, 1-2 agent every day, each 1-2 bag.
Matched group gives omeprazole capsule (production of Changzhou four medicine pharmaceutical factory), 20mg, and every day 2 times is oral, 8 weeks courses for the treatment of, and period in a medicine is stopped using affects this medicine observed, and terminates rear evaluation curative effect the course for the treatment of.
1.5 therapeutic evaluation
1.5.1 clinical symptoms integration is according to the clinical symptoms of gastroesophageal reflux disease in 2006 " diagnostic criteria of Chinese gastroesophageal reflux disease National Consensus ", and drafts primary disease clinical symptoms integration with reference to related indication stage division in " new Chinese medicine guideline of clinical investigations ": this type of symptom never appears in asymptomatic expression; Slight expression accidentally occurs, is less than every day once, does not affect work and rest; Moderate represents that every day occurrence frequency is between 1 time to 3 times; Severe represents that every day, occurrence frequency was greater than 3 times, affects work and rest.Main suit's cough by above 4 grades from light to heavy successively with., 3,6,9 to score, gastroesophageal reflux disease cardinal symptom (heartburn, belch, acid regurgitation, chest pain) is scored with 0,2,4,6, and other general symptoms are scored with 0,1,2,3.
1.5.2 clinical efficacy criterion recovery from illness: clinical symptom disappearance, symptom integral reduces >=95%; Effective: clinical symptoms disappears substantially (having symptom to disappear very soon though even), and symptom integral reduces 70%-94%; Effective: clinical symptoms does not disappear, but alleviate than before, symptom integral reduces 30-6%; Invalid: clinical symptoms does not disappear, degree does not alleviate, and symptom integral reduces < 30%.Computing formula: integration × 100% before (before treatment the rear integration of integration-treatment)/treatment.
1.6 statistical method
SPSS 15.0 statistical software is adopted to add up. between two groups, baseline mean compares employing t inspection, to represent, compare employing rank test between partial velocities data two groups, represent with median (range interquartile) ［ M (Q) ］, between two groups, efficient comparison adopts X
2inspection, with P < 0.05 for difference has statistical significance.
2. result
2.1 main clinic symptoms integral contrasts
Before and after two groups of gastroesophageal reflux induced cough patient treatments, main clinic symptoms integration is through test of normality, and prompting is partial velocities.Through rank test, main clinic symptoms before two groups of treatments: cough, acid regurgitation, heartburn, belch integral contrast no significant difference (the equal > 0.05 of P).After two groups of treatments, main clinic symptoms integration all obviously reduces before comparatively treating, there is statistical significance (the equal < 0.01 of P) through rank test statistical result difference, cough after prompting treatment group and treatment of control group, acid regurgitation, heartburn, belch symptom have obvious alleviation.
Before and after the cough for the treatment of group and matched group, belch symptom treatment, the difference of integration has statistical significance (the equal < 0.05 of P) through rank test comparing difference, and prompting treatment group is better than matched group improving in GERC patient's cough, belch symptom; Before and after the acid regurgitation of two groups, heartburn symptom treatment, the difference of integration is through rank test comparing difference not statistically significant (the equal > 0.05 of P), and prompting treatment group and matched group are to improve effect in acid regurgitation, heartburn symptom suitable.In table 1
Table 1 liang group gastroesophageal reflux induced cough patient's main clinic symptoms integral contrast (M, Q)
| Group | Cough | Acid regurgitation | Heartburn | Belch |
| Treatment group (n=60) | ||||
| Before treatment | 6.00,0.38 | 4.00,0.60 | 4.00,0.44 | 4.00,0.36 |
| Before treatment | 0.00,0.22* | 0.00,0.28 | 0.00,0.17 | 0.00,0.27 △ |
| Matched group (n=60) | ||||
| Before treatment | 6.00,0.20 | 4.00,0.42 | 4.00,0.47 | 4.00,0.42 |
| Before treatment | 0.00,0.43 | 0.00,0.22 | 0.00,027 | 2.00,0.40 |
Note: compared with matched group,
△p < 0.05.
2.2 clinical symptoms total marks compare
Before two groups of gastroesophageal reflux induced cough patient clinical symptom treatments, total mark checks comparing difference not statistically significant (P=0.842, > 0.05) through t, and first two groups of prompting treatment has comparability.After two groups of treatments, clinical symptoms total mark has statistical significance (P=0.037, < 0.05) through rank test comparing difference, and prompting treatment group is alleviated GERC patient clinical symptom and is obviously better than matched group.In table 2.
A table 2 liang group gastroesophageal reflux induced cough patient clinical symptom total mark compares (X ± s)
| Group | Number of cases | Before treatment | After treatment |
| Treatment group | 60 | 27.10±6.51 | 5.00,1.23 △ |
| Matched group | 60 | 28.54±7.26 | 1.00,1.46 |
Note: compared with matched group,
△p < 0.05.
2.3 clinical total obvious effective rates compare
Through treatment, the overall obvious effective rate for the treatment of group (recovery from illness+effective) is 78.33%, and matched group is 43.33%, through X
2inspection difference has statistical significance (P < 0.05), and prompting treatment group uses the logical overall clinical efficacy rate falling stomach function regulating side's treatment gastroesophageal reflux induced cough patient to be better than matched group omeprazole.In table 3.
A table 3 liang group gastroesophageal reflux induced cough patient clinical general curative effect compares (example)
| Group | Number of cases | Recovery from illness | Effective | Effectively | Invalid |
| Treatment group | 60 | 5 | 42 | 8 | 5 |
| Matched group | 60 | 1 | 25 | 17 | 17 |
Claims (8)
1., for a health tea for gastroesophageal reflux induced cough, be made up of the crude drug of following weight:
Radix Glycyrrhizae 1-5 part, Semen Coicis 1-5 part, Semen Armeniacae Amarum 1-5 part, Rhizoma Phragmitis 1-5 part, Flos Rosae Rugosae 1-5 part, Flos Chrysanthemi 1-5 part, Flos Jasmini Sambac 1-5 part, Flos Lonicerae 1-5 part, Massa Medicata Fermentata 1-5 part, Fructus Hordei Germinatus 1-5 part, Fructus Crataegi 1-5 part.
2., as claimed in claim 1 for the health tea of gastroesophageal reflux induced cough, be made up of the crude drug of following weight:
Radix Glycyrrhizae 2-4 part, Semen Coicis 2-4 part, Semen Armeniacae Amarum 2-4 part, Rhizoma Phragmitis 2-4 part, Flos Rosae Rugosae 2-4 part, Flos Chrysanthemi 2-4 part, Flos Jasmini Sambac 2-4 part, Flos Lonicerae 2-4 part, Massa Medicata Fermentata 2-4 part, Fructus Hordei Germinatus 2-4 part, Fructus Crataegi 2-4 part.
3., as claimed in claim 2 for the health tea of gastroesophageal reflux induced cough, be made up of the crude drug of following weight:
3 parts, Radix Glycyrrhizae, Semen Coicis 3 parts, 3 parts, Semen Armeniacae Amarum, Rhizoma Phragmitis 3 parts, Flos Rosae Rugosae 3 parts, Flos Chrysanthemi 3 parts, Flos Jasmini Sambac 3 parts, Flos Lonicerae 3 parts, Massa Medicata Fermentata 3 parts, 3 parts, Fructus Hordei Germinatus, Fructus Crataegi 3 parts.
4., as claimed in claim 2 for the health tea of gastroesophageal reflux induced cough, be made up of the crude drug of following weight:
1 part, Radix Glycyrrhizae, Semen Coicis 5 parts, 1 part, Semen Armeniacae Amarum, Rhizoma Phragmitis 5 parts, Flos Rosae Rugosae 1 part, Flos Chrysanthemi 5 parts, Flos Jasmini Sambac 1 part, Flos Lonicerae 5 parts, Massa Medicata Fermentata 1 part, 5 parts, Fructus Hordei Germinatus, Fructus Crataegi 1 part.
5., as claimed in claim 2 for the health tea of gastroesophageal reflux induced cough, be made up of the crude drug of following weight:
5 parts, Radix Glycyrrhizae, Semen Coicis 1 part, 5 parts, Semen Armeniacae Amarum, Rhizoma Phragmitis 1 part, Flos Rosae Rugosae 5 parts, Flos Chrysanthemi 1 part, Flos Jasmini Sambac 5 parts, Flos Lonicerae 1 part, Massa Medicata Fermentata 5 parts, 1 part, Fructus Hordei Germinatus, Fructus Crataegi 5 parts.
6., as claimed in claim 2 for the health tea of gastroesophageal reflux induced cough, be made up of the crude drug of following weight:
2 parts, Radix Glycyrrhizae, Semen Coicis 4 parts, 2 parts, Semen Armeniacae Amarum, Rhizoma Phragmitis 4 parts, Flos Rosae Rugosae 2 parts, Flos Chrysanthemi 4 parts, Flos Jasmini Sambac 2 parts, Flos Lonicerae 4 parts, Massa Medicata Fermentata 2 parts, 4 parts, Fructus Hordei Germinatus, Fructus Crataegi 2 parts.
7., as claimed in claim 2 for the health tea of gastroesophageal reflux induced cough, be made up of the crude drug of following weight:
4 parts, Radix Glycyrrhizae, Semen Coicis 2 parts, 4 parts, Semen Armeniacae Amarum, Rhizoma Phragmitis 2 parts, Flos Rosae Rugosae 4 parts, Flos Chrysanthemi 2 parts, Flos Jasmini Sambac 4 parts, Flos Lonicerae 2 parts, Massa Medicata Fermentata 4 parts, 2 parts, Fructus Hordei Germinatus, Fructus Crataegi 4 parts.
8. the application of the health tea for gastroesophageal reflux induced cough described in the arbitrary claim of claim 1-8 in the medicine of preparation treatment gastroesophageal reflux induced cough.
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