CN103599503A - Medicine for treating critical diseases and preparation method thereof - Google Patents
Medicine for treating critical diseases and preparation method thereof Download PDFInfo
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- CN103599503A CN103599503A CN201310565130.5A CN201310565130A CN103599503A CN 103599503 A CN103599503 A CN 103599503A CN 201310565130 A CN201310565130 A CN 201310565130A CN 103599503 A CN103599503 A CN 103599503A
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Abstract
The invention discloses a medicine for treating critical diseases, and belongs to a traditional Chinese medicine compound. The medicine is prepared from the following components in parts by weight: 100-180 parts of monkshood, 100-180 parts of dried ginger and 100-160 parts of liquorice. The medicine has the characteristics of high efficiency, no toxicity, wide medicinal herb resources, economy and the like and is convenient to take, and has the effects of improving the vital signs of patients with critical diseases and restoring the metabolism and vitality of organisms, thus prolonging the longevity of the patients with the critical diseases and reducing the short-term death rate of the patients with the critical diseases. After the high-dose medicine is taken, no toxic and side effects occur. The invention also discloses a preparation method of the medicine for treating the critical diseases.
Description
Technical field
The disease that the present invention relates to endanger treatment, specifically a kind of medicine of disease and preparation method thereof of endangering that is used for the treatment of.
Background technology
Danger disease (Critical illness) refers to that a kind of to show as organism metabolism wild on the decline, the symptom of hypothermia (24 ℃ of <), hypoglycemia (< 3.0mmol/L).The danger disease that various disease causes clinically all presents the disease picture of " negative and positive certainly from ", and hypoglycemia appears in patient, and mortality risk is soaring, and hypoglycemia and dead correlation degree represent dose dependent feature.We find in clinical observation, scientific research and teaching Process of experiment, tell greatly and rush down greatly, and profuse sweating massive hemorrhage, prolonged illness etc. cause critically ill.Patient's dripping cold sweat, cold limbs, pale complexion, field gray or sallow, cyanosis, incontinence of urination and defecation, shock or god know stupor, weak breathing in critical, pulse condition fine late a little less than, similar " SHAO YIN syndrome faint pulse being about to disappear disease ", if do not rescue in time, will soon cause death.Danger disease is found in inside and outside, Fu,Er Ge section: (1) severe trauma: multiple trauma, large-area burns, crush syndrome etc.(2) severe infections: as acute obstructive suppurative cholangitis, severe abdominal infection, be secondary to post-traumatic infection etc.(3) surgery large operation: as operation on vessels of heart, thoracic surgery, craniocerebral operations, pancreaticoduodenectomy etc.(4) various types of shocks.(5) hypoxemia that a variety of causes causes: as aspiration pneumonitis and acute lung injury etc.(6) cardiac arrest is recovered not exclusively or recovery delay.(7) hypertensive state of pregnancy.(8) other: as Acute Hemorrhagic Necrotic Pancreatitis, strangulated intestinal obstruction, a large amount of quick blood transfusion, transfusion etc.(9) may there are some potential factors of easily sending out in the patient who has: as low inferior in advanced age, immunologic hypofunction, malnutrition, chronic disease and organ reserve function.Clinical treatment often adopts Comprehensive Treatment, and related measure is: (1), for the symptom that infects, suffers a shock, is given shock and entangled acid, and infection control, improves the corresponding measures such as disorders of hemostasis timely and effectively; (2) be directed to each important organ nonfunction, give corresponding organs function Supporting Therapy, as clean therapies of blood such as respirator and lasting kidney adjutant therapy (CRRT), plasma exchange method (PE), polymyxin B cured fiber column hold-up hemoperfusions (PMX-DHP).(3), to digestive tract hemorrhage person, adopt in time hemostasis, blood transfusion, application H
2receptor blocking agent intravenous drip; (4) aid nutrition metabolism supporting treatment.Yet above-mentioned clinical treatment measure usually can not get desirable curative effect, even also can cause multiple organ failure, MOF's deterioration, and just for a certain single symptom, treat accordingly measure, and shortage resultant effect and whole curative effect, this just makes the mode for the treatment of and process become complicated and thorny, and also can cause the financial burden that patient is larger.Therefore, we are necessary to find and invention can not be the medicine that single symptom is treated to danger disease, this will bring many benefits to danger disease patient's treatment, as therapeutic modality simply, more easy to operate, and the negative consequences (as: cognitive dysfunction, renal function injury, opportunistic infection etc.) that can avoid mechanical interventional therapy to bring, also can reduce patient's medical treatment burden.
Summary of the invention
The object of the present invention is to provide a kind of medicine of endangering disease that is used for the treatment of.
This medicine, is made by following raw material by weight ratio: 100 ~ 180 parts of Radix Aconiti Lateralis Preparatas, 100 ~ 180 parts of Rhizoma Zingiberiss, 100 ~ 160 parts, Radix Glycyrrhizae.
The preferred weight portion proportioning of medicine is: 130 ~ 160 parts of Radix Aconiti Lateralis Preparatas, 130 ~ 160 parts of Rhizoma Zingiberiss, 140 ~ 160 parts, Radix Glycyrrhizae.
The weight portion proportioning being more preferably is: 150 parts of Radix Aconiti Lateralis Preparatas, 150 parts of Rhizoma Zingiberiss, 150 parts, Radix Glycyrrhizae.
Described raw material is dry product.
Can also be by the medicine of above-mentioned gained according to conventional medicine manufacture method, make and take its pharmaceutically acceptable dosage form that is whole compositions or partial elements.
Medicine of the present invention, in making pharmaceutically acceptable whole dosage form, preferably be take its oral liquid as whole compositions or partial elements, injection, tablet, capsule or granule.
Another object of the present invention is to be provided for the preparation method of the medicine for the treatment of danger disease.
This preparation method, comprises the steps:
(1) according to parts by weight of raw materials proportioning, take raw material, cataclasm;
(2) add 5 ~ 9 times of water gagings of raw material total amount, boil rear little fire and extract 3 ~ 6 hours;
(3) filter and remove residue, obtains water extraction liquid.
In order to extract the leaching of convenient and effective ingredient, in step (1), raw material is cataclasm to 1 ~ 3mm.
Equally, for the composition that extracts and completely, obtain more effective ingredient, the way that the present invention preferably takes gradation to extract.In step (2), the total amount of the water adding is divided into three parts, minute extract for three times, add a water boil at every turn after little fire extract 3 ~ 6 hours.
In order to control quality, and consider taking dose, in step (3), also comprise afterwards gained water extraction liquid is concentrated into 1 ~ 2 gram of every milliliter contained.
Described every milliliter contained, refers to the ratio of the corresponding raw material total amount of every milliliter of concentrated solution, in raw material total amount (gram) divided by the result of concentrated solution volume (milliliter).
The pharmacological action of the each component in medicine of the present invention is:
Radix Aconiti Lateralis Preparata: pungent, sweet, hot greatly; Poisonous.GUIXIN, kidney, spleen channel.There is recuperating depleted YANG and rescuing the patient from collapse, mend fire supporing yang, by the effect of wind-cold damp pathogen.Cure mainly YANG-depletion collapse, cold extremities faint pulse, sexual impotence, cold womb, trusted subordinate's cold type of pain, deficiency and coldness is vomited and diarrhoea, YIN-cold edema, arthralgia due to cold-dampnes etc.< < book on Chinese herbal medicine converges says > > cloud: " Radix Aconiti Lateralis Preparata, recuperating depleted YANG gas, loose YIN-cold.The time of all genus yang deficiency negative electrodes, the heat symptom-complex person of lung kidney unit, clothes had a dead distinguished service." for excess of YIN gram sun, loss of YANG due to profuse perspiration, vomiting and diarrhoea is fainted contrary, cold extremities faint pulse, trusted subordinate's cold type of pain, cold-dysentery, beriberi edema, anemofrigid-damp arthralgia, sexual impotence, cold womb, deficiency and coldness is vomited and diarrhoea, YIN-cold edema, yang deficiency diseases caused by exogenous pathogenic factor, the disease of carbuncle of yin nature skin infection and all chronic diseaseses.And Radix Aconiti Lateralis Preparata is to hypophysis---interrenal system has excitation, can also excited vagus and tool cardiotonic.Pharmacological action: the effects such as the function of heart tonifying, arrhythmia, shock, blood vessel dilating, increase blood flow, adrenal cortex reinforcing system, cold resistance; And antiinflammatory, analgesia, cold resistance, the effects such as tolerance of raising to anoxia.
Rhizoma Zingiberis: acrid in the mouth, hot in nature.Return spleen, stomach, the heart, lung meridian.Have that warming spleen and stomach for dispelling cold, recuperating depleted YANG are promoted blood circulation, the effect of dampness expectorant, warming the lung to resolve fluid-retention.Cure mainly coldness and pain in the epigastrium, vomit, have loose bowels, cold extremities faint pulse, YANG-depletion faint contrary, cold fluid-retention is breathed with cough, arthralgia due to cold-dampnes.Pharmacological action: have excited guinea pig in vitro intestinal tube, excited vasomotor center and heart respiratory center, excited heart, antihistamine, antibacterial, suppress the effects such as platelet aggregation.
Radix Glycyrrhizae: sweet in the mouth, property is flat, nontoxic.The effect with QI invigorating invigorating middle warmer, relieving spasm to stop pain, nourishing the lung to arrest cough, eliminating fire and detoxication, coordinating the actions of various ingredients in a prescription, diuresis.Cure mainly that the anxious pain of asthenia lack of appetite, leanness yellowish complexion, shortness of breath and palpitation, stomachache loose stool, extremity contraction, hysteria, cough and asthma, laryngopharynx swelling and pain, carbuncle skin ulcer swell and ache, infantile carbuncle and medicine, alimentary toxicosis.Also for the anxious pain of weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen and extremity contraction, pyretic stranguria dysurea, carbuncle sore tumefacting virus and cushion toxicity, strong.Pharmacological action: there is the functions such as antiinflammatory, antiviral, treatment ulcer, protecting liver and detoxication, enhancing immunologic function, anti-cancer and cancer-preventing, interferon inducer and cell immunomodulator.Clinically be widely used in treating gastric and duodenal ulcers, various acute, chronic hepatitis, bronchitis, acquired immune deficiency syndrome (AIDS) and atherosclerosis forms.
Above-mentioned raw materials component compatibility, Radix Aconiti Lateralis enters the heart, spleen, kidney channel, warm kidney-Yang invigorating, broken loose YIN-cold, recuperating depleted YANG and rescuing the patient from collapse.Raw with can fastly reach inside and outside with warming YANG by trembling with fear.Hot Rhizoma Zingiberis, enters the heart, spleen, lung meridian, warming spleen and stomach for dispelling cold, supporing yang promoting blood circulation.The same use of Radix Aconiti Lateralis Preparata and Rhizoma Zingiberis, a temperature is congenital in to give birth to the day after tomorrow, and a temperature will be congenital to support the day after tomorrow, and mutual reinforcement between is use, and the power of warming the interior recuperating depleted YANG increases.The use of Radix Glycyrrhizae Preparata has three: QI invigorating invigorating middle warmer first, makes full side's temperature compensation combination, to control deficiency and coldness originally; Second sweet slow Rhizoma Zingiberis Recens, attached high strong property, make its reducing YIN to revive YANG and the sudden and violent loose anxiety of nothing; Three mediation property of medicine, and make efficacy of a drug effect lasting, be for adjuvant drug is double, to make the use of medicine.Three medicines share, and the large heat of great Xin can make sun faint back again, bring into play the dispel effect of YIN-cold of warm heart kidney, improve heart kidney yang and decline, yin-cold excess due to YANG-depletion collapse, the effect of the symptoms such as cold extremities faint pulse, alleviates danger disease symptom.
Above-mentioned raw materials component compatibility, can recuperating depleted YANG and rescuing the patient from collapse, alleviates danger disease crisis, pulls through, and turns danger into safety, and turns ' dissociation of YIN from YANG ' for ' reestablishment to yin-yang equilibrium '.
Experiment confirms, the compound Chinese medicinal preparation that is used for the treatment of chance danger disease of the present invention, there is the danger of prolongation disease mouse life, reduce mortality rate, and can improve danger disease mouse metabolism situation, and after medication, having no side effect, is a kind of efficient, low toxicity, wide, easy to use, the economic compound Chinese medicinal preparation in medicine source.
The specific embodiment
Medicine preparation
Embodiment 1
Take: Radix Aconiti Lateralis Preparata 150g, Rhizoma Zingiberis 150g, Radix Glycyrrhizae 150g.
Above-mentioned raw materials is dry product.
Then,
(1) cataclasm to 2mm;
(2) add water 2500g, boil rear little fire and extract 4 hours;
(3) filter and remove residue, is concentrated into water extraction liquid 450ml.It is 1 gram of every milliliter contained.
Embodiment 2
Take: Radix Aconiti Lateralis Preparata 130g, Rhizoma Zingiberis 130g, Radix Glycyrrhizae 160g.
Above-mentioned raw materials is dry product.
Then,
(1) cataclasm to 2mm;
(2) add water 1000g, boil rear little fire and extract 5 hours; After pouring out medicinal liquid, add again water 1000g, boil rear little fire and extract 5 hours; After pouring out medicinal liquid, add again water 1200g, boil rear little fire and extract 5 hours, pour out medicinal liquid; Merge medicinal liquid.
(3) filter and remove residue, is concentrated into water extraction liquid 260ml.Be 2 grams of every milliliter containeds.
Embodiment 3
Take: Radix Aconiti Lateralis Preparata 180g, Rhizoma Zingiberis 180g, Radix Glycyrrhizae 100g.
Above-mentioned raw materials is dry product.
Then,
(1) cataclasm to 2mm;
(2) add water 1220g, boil rear little fire and extract 5 hours; After pouring out medicinal liquid, add again water 1000g, boil rear little fire and extract 3 hours; After pouring out medicinal liquid, add again water 1000g, boil rear little fire and extract 3 hours, pour out medicinal liquid; Merge medicinal liquid.
(3) filter and remove residue, obtains water extraction liquid 350ml.Be 1.31 grams of every milliliter containeds.
Modeling and Drug therapy embodiment
48 of the male mices of Kunming kind, body weight 16.9 ± 2 g, 1 monthly age ，You Medical Colleges Of Guilin's zoopery center provides, credit number: GLMC20130308HL.
Danger disease mice inclusive criteria: occur in zoopery or teaching that disease shows as that diet reduces, body is thin, eye is narrowed, hogback, movable minimizing; Biochemistry detection blood glucose < 3.0mmol/L, the mice that body temperature < is 24 ℃.Danger disease mice is divided into 2 group model groups (CI, 48): treatment group and medication therapy groups of the present invention are two groups, 24 every group.
Treatment group is not refused Drug therapy, every day gavage tap water, 1 milliliter every.
Medication therapy groups of the present invention gives the medicine of gained of the present invention and treats.Drug use Preparation Example 1 gained.Every day gavage once, each 1 milliliter, treat continuously drug withdrawal after 7 days, observe mouse life, life and metabolic index.Life and metabolic index detect: every day entry animal survival situation, and analytic metabolism index comprises body temperature, body weight, 24 hours food-intakes, amount of drinking water, urine amount (metabolic cage collection sample); Tail vein sugar is measured by portable blood sugar detector.In first week, detect once every day, and danger disease changes into weekly and detecting once after calming down.
Observe to find, 48 mices of model group not the mortality rate in treatment group mice 7 days up to 100%.
Medication therapy groups of the present invention, mice feed increases, and recovers gradually daily routines, and more than fervescence to 32 ℃, blood glucose gos up, and in 30 days, mortality rate is only 25%.
Result from experiment, the medicine that is used for the treatment of the disease of endangering of the present invention has the danger of prolongation disease mouse life, reduces mortality rate, and can improve the metabolism status such as mice dietary amount is few, blood glucose is low, body temperature is low, and after medication, having no side effect, is the herbal mixture of wide, easy to use, the economic treatment danger disease of a kind of efficient, low toxicity, medicine source.
Claims (8)
1. be used for the treatment of the medicine of endangering disease, it is characterized in that: by following raw material by weight ratio, made: 100 ~ 180 parts of Radix Aconiti Lateralis Preparatas, 100 ~ 180 parts of Rhizoma Zingiberiss, 100 ~ 160 parts, Radix Glycyrrhizae.
2. medicine according to claim 1, is characterized in that: 130 ~ 160 parts of Radix Aconiti Lateralis Preparatas, 130 ~ 160 parts of Rhizoma Zingiberiss, 140 ~ 160 parts, Radix Glycyrrhizae.
3. medicine according to claim 1 and 2, is characterized in that: 150 parts of Radix Aconiti Lateralis Preparatas, 150 parts of Rhizoma Zingiberiss, 150 parts, Radix Glycyrrhizae.
4. the dosage form of medicine described in claim 1, comprises and take its pharmaceutically acceptable dosage form that is whole compositions or partial elements.
5. the dosage form of medicine described in claim 1 or 4, comprises and take its oral liquid as whole compositions or partial elements, injection, tablet, capsule or granule.
6. the preparation method of medicine described in claim 1, comprises the steps:
(1) according to parts by weight of raw materials proportioning, take raw material, cataclasm;
(2) add 5 ~ 9 times of water gagings of raw material total amount, boil rear little fire and extract 3 ~ 6 hours;
(3) filter and remove residue, obtains water extraction liquid.
7. preparation method claimed in claim 6, in step (1), raw material is cataclasm to 1 ~ 3mm; In step (3), also comprise afterwards gained water extraction liquid is concentrated into 1 ~ 2 gram of every milliliter contained.
8. preparation method claimed in claim 6, in step (2), is divided into three parts by the total amount of the water adding, and minute extracts for three times, add a water boil at every turn after little fire extract 3 ~ 6 hours.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017181987A1 (en) * | 2016-04-21 | 2017-10-26 | 张东 | Traditional chinese medicine composition effective against various symptoms, and derivative and preparation of same |
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Non-Patent Citations (3)
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| 赵法新等主编: "《国家基本药物中成药的辨证应用》", 31 July 2003, 中医古籍出版社 * |
| 门纯德: "《名方广用》", 28 February 1990, article "四逆汤《伤寒论》", pages: 2-3 * |
| 门纯德: "《名方广用》", 28 February 1990, 科学技术文献出版社重庆分社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017181987A1 (en) * | 2016-04-21 | 2017-10-26 | 张东 | Traditional chinese medicine composition effective against various symptoms, and derivative and preparation of same |
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Effective date of registration: 20151012 Address after: 541004, No. 109, No. 1, North Road, Qixing District, Guilin, the Guangxi Zhuang Autonomous Region Applicant after: Guilin Medical College Address before: Two North Road City Qixing District, Guilin city 541004 No. 109 the Guangxi Zhuang Autonomous Region Applicant before: Zhao Hailu |
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Application publication date: 20140226 |