CN104491498A - Drug for treating recurrent aphtha - Google Patents

Abstract

The invention discloses a drug for treating recurrent aphtha. The drug comprises 10-14g of Chinese angelica, 10-14g of peach seed, 8-10g of safflower, 10-14g of rheum officinale, 10-14g of radix astragali, 10-14g of Chinese yam, 8-10g of rhizoma arisaematis, 5-7g of bitter orange, 8-10g of processed pinellia tuber, 5-7g of reddish orange, 3-5g of bamboo shavings, 5-7g of trichosanthes root, 5-7g of immersed pangolin, 2-4g of asarum herb and 4-6g of licorice root. A preparation method of the drug comprises the following steps of 1, putting the traditional Chinese medicines into a medicine pot, and carrying out immersion for 30min, 2, adding five slices of ginger into the traditional Chinese medicines, and carrying out decoction by boiling the traditional Chinese medicines by strong fire, carrying out decoction by a slow fire for 30min, adding rheum officinale and peach seed into the decoction and carrying out decoction until the decoction has a volume of about 200ml, 3, carrying out filtration to obtain a medicine juice, and 4, putting the boiled medicine juice into a package bottle with a volume of about 200ml. The preparation method utilizes various traditional Chinese medicines and a scientific preparation technology. The drug contains a plurality of effective drug components, has a strict formula, a wide drug source, a low cost, substantial curative effects and no toxic or side effect, and can fast cure recurrent aphtha and remove patient pain.

Description

A kind of medicine for the treatment of recurrent aphtha

Technical field: the present invention relates to a kind of medicine for the treatment of recurrent aphtha.

Background technology: along with the raising of living standards of the people, people put physical condition in critical positions.The cause of disease of recurrent aphtha is complicated, and each family differs to its pathogenesis understanding, Chinese medicine think primary disease generation duty in fire, many because of diseases caused by exogenous pathogenic factor six climate exopathogens dryness-fire, or internal organs internal injury, pathogenic fire derived from stagnation of liver-QI, heart-fire is flourishing, rising up of the stomach-fire, disarmony between the heart and kidney, hyperactivity of deficient fire is fumigated and is fallen ill in mouth, and the feature that recurrence is aphtha is Relapse rate outbreak, do when time heals, touching difficulty more.Primary disease is contain in pathogenic heat, and with the passing of time impairment of YIN, causes expectorant and cause the stasis of blood, and the expectorant stasis of blood is cementing, and the venation stasis of blood is stagnant, and qi-blood circulating is not smooth, and local organization is lost in precise and tiny the supplementing nutrition of QI and blood, and this is the key factor of primary disease recurrent exerbation.Intimately, turbid, the blood stasis of expectorant is cemented in local, blockage of meridian, stagnation of QI and blood may bring about pain, therefore violent causalgia.Scorching hot pain is another important indication of recurrent aphtha.And the medicine major part for the treatment of now recurrent aphtha has side effect, and price is more expensive, and therapeutic effect is undesirable.

Summary of the invention: object of the present invention just there is provided and utilizes Chinese patent drugs for treatment recurrent aphtha, and prescription is rigorous, medicine source is wide, and cost is low, evident in efficacy, a kind of medicine for the treatment of recurrent aphtha had no side effect.

The technical scheme that the present invention is adopted for achieving the above object is: its crude drug prescription is: Radix Angelicae Sinensis 10-14g, Semen Persicae 10-14g, Flos Carthami 8-10g, Radix Et Rhizoma Rhei 10-14g, Radix Astragali 10-14g, Rhizoma Dioscoreae 10-14g, Jiang Nanxing 8-10g, Fructus Aurantii Immaturus 5-7g, Rhizoma Pinelliae Preparatum 8-10g, Exocarpium Citri Rubrum 5-7g, Caulis Bambusae In Taenia 3-5g, Radix Trichosanthis 5-7g, bubble Squama Manis 5-7g, Herba Asari 2-4g, Radix Glycyrrhizae 4-6g; Its manufacture method, for getting Semen Persicae, rhubarb tablets, uses yellow wine uniform spraying, slightly soak, vexed, with the micro-stir-fry of slow fire, when deepening to color and luster, taking-up cools; All the other medicines are put into medicine pot, add water and exceed medicine top levels 3cm, soak 30min, with 5, Rhizoma Zingiberis Recens, start to boil, first boil with high heat, when then boiling 30min with slow fire, enter Radix Et Rhizoma Rhei, Semen Persicae, continue to endure to about 200ml, after leach medicinal liquid; Reenter water and exceed medicine top levels 2cm, then decoct about 20min, during to 200ml, leach medicinal liquid, by twice medicinal liquid hybrid filtering, finally the medicinal liquid boiled is poured in 200ml Packaging Bottle respectively.

The cause of disease of recurrent aphtha is complicated, and each family differs to its pathogenesis understanding.Motherland's medical science think primary disease generation duty in fire, how because of diseases caused by exogenous pathogenic factor six climate exopathogens dryness-fire, or internal organs internal injury, pathogenic fire derived from stagnation of liver-QI, heart-fire is flourishing, rising up of the stomach-fire, disarmony between the heart and kidney, and hyperactivity of deficient fire is fumigated and fallen ill in mouth, just for excess-fire is for suffering from, sick of a specified duration be asthenic fire."Nei Jing" just has " year gold too late, scorching fire is capable ... the sick aphtha of the people " and the description of " all sufferings skin ulcers all belong to fire ".Thereafter all there are discussion in the successive dynasties, " General Treatise on the Cause and Symptoms of Diseases dispute time " carry " spleen meridian also.Spleen-QI connecting with mouth, internal organs intenseness of heat, heat takes advantage of temper to rush in dispute, therefore aphtha of the mouth and tongue also." " Shengji Zonglu " meaning " aphtha person.Have heat by heart spleen, gas rushes to Jiao.A smoked dispute, pretends skin ulcer also." Jing-Yue Complete Works cloud: " aphtha is unhealed year after year, and this asthenic fire is also." meaning in " ability to speak class want ": " deficiency-cold in middle-JIAO, part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels YIN-fire, respectively caused by the change of disease for aphtha, part of the body cavity above the diaphragm housing the heart and lungs excess-heat." ... and to it will be argued that, recurrent aphtha why recurrent exerbation, more, it is that prolonged illness causes healthy energy damage to touching difficulty at all, without resisting heresy strenuously, deficient vital QI leading to lingering of pathogen therefore.Intenseness of heat impairment of YIN, with the passing of time causing void, to cause the stasis of blood be this pathogenetic feature." Plain Questions " day: " disease enters deeply for a long time, and it is puckery that battalion defends trip, and during meridians, thin event is obstructed." Miraculous Pivot: " dampness is not all right, does not fall apart in blood coagulation is accumulate, and body fluid is puckery to be oozed, and and does not go, and long-pending all one-tenth." no matter asthenic fire excess-fire, be all YANG pathogen, recurrent exerbation, easily consumption impairment of YIN liquid, refining liquid is expectorant, the turbid retardance of expectorant; Pyretic toxicity enters network, decocts blood, and blood vessels stagnate and the hyperamization stasis of blood; Intimately, turbid, the blood stasis of expectorant is cemented in oral area, and intenseness of heat blood loses meat corruption and hinders film and cause aphtha.Therefore exuberant evil_heat, expectorant stasis of blood knot is the pathogenic characteristic of recurrent aphtha.Call as " reformulating popular Treatise on Febrile Diseases ": " exuberant evil_heat, stagnated fire is fumigated, blood gelling ".Pathogenesis key is " expectorant, void, the stasis of blood ".

Theory of Chinese medical science is thought, medicine has the speciality of individual character, and there is gregarious magical effect side, in determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs medication.This crude drug derives from natural plants, Radix Angelicae Sinensis, Semen Persicae, Flos Carthami eliminating blood stasis and promoting blood circulation in we, removing obstruction in the collateral to relieve pain; Radix et Rhizoma Rhei (stir-fried with wine) promoting blood circulation to restore menstrual flow, attacks by the solidifying stasis of blood, and it is descending to draw the stasis of blood, is monarch drug altogether; The righting of Radix Astragali QI invigorating, tonic blood and growing muscle, Rhizoma Dioscoreae spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating primordial QI reinforcing; Rhizoma Arisaematis drying dampness to eliminate phlegm, dispelling wind-evil and transforming calculus, Fructus Aurantii Immaturus therapeutic method to keep the adverse QI flowing downwards row expectorant, the special removing dampness and eliminating phlegm of Rhizoma Pinelliae merit, the expectorant of the Exocarpium Citri Rubrum therapeutic method to keep the adverse QI flowing downwards, Caulis Bambusae In Taenia Qinghua heat-phlegm, all medicines share, and expectorant quench are fallen, meridians tonneau, activating QI to alleviate the depression, with righting, dampness, eliminate the phlegm, and are ministerial drug altogether.Radix Trichosanthis, Squama Manis share, can dispersing swelling and dissipating binds, and Herba Asari rises loose going on, and priming goes directly disease institute, and Radix Glycyrrhizae relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, altogether for assistant makes.Two sides share, and become blood circulation promoting and blood stasis dispelling altogether, the merit of the dredging collateral that eliminates the phlegm, and the stasis of blood is dispelled new life, expectorant from falling, network from logical, first runback, pain from relaxing, sick spontaneous recovery.

The invention has the beneficial effects as follows: owing to have employed various Chinese crude drug and science preparation technology, its goods include multi-medicament composition, and prescription is rigorous, medicine source is wide, and cost is low, evident in efficacy, has no side effect.There is circulation of qi promoting removing blood stasis with potent drugs, San Disorder softening the hard mass effect, oral cavity chronic ulcer tissue is formed and surrounds phagocytosis, energy acute activation lymphocytic immunity system call interception human body gene is to normal equilibrium state, suppress chronic ulcer tissue continued growth, oral ulcer is recovered gradually, until ulcer and clinical merging symptom full recovery normal level through astringent therapy; There is supplementing QI and nourishing YIN righting, regulating functional activities of qi simultaneously, pathological change of oral cavity deep tissues cell can be repaired, strengthen resistance against diseases, suppress oral ulcer recurrence, regeneration, reach the effect thoroughly cured.And technique is simple, short treating period, instant effect, not easily recurs.Recurrent aphtha can be cured rapidly, remove the misery of patient.

Detailed description of the invention: embodiment 1: its crude drug prescription is: Radix Angelicae Sinensis 10-14g, Semen Persicae 10-14g, Flos Carthami 8-10g, Radix Et Rhizoma Rhei 10-14g, Radix Astragali 10-14g, Rhizoma Dioscoreae 10-14g, Jiang Nanxing 8-10g, Fructus Aurantii Immaturus 5-7g, Rhizoma Pinelliae Preparatum 8-10g, Exocarpium Citri Rubrum 5-7g, Caulis Bambusae In Taenia 3-5g, Radix Trichosanthis 5-7g, bubble Squama Manis 5-7g, Herba Asari 2-4g, Radix Glycyrrhizae 4-6g; Its manufacture method, for getting Semen Persicae, rhubarb tablets, uses yellow wine uniform spraying, slightly soak, vexed, with the micro-stir-fry of slow fire, when deepening to color and luster, taking-up cools; All the other medicines are put into medicine pot, add water and exceed medicine top levels 3cm, soak 30min, with 5, Rhizoma Zingiberis Recens, start to boil, first boil with high heat, when then boiling 30min with slow fire, enter Radix Et Rhizoma Rhei, Semen Persicae, continue to endure to about 200ml, after leach medicinal liquid; Reenter water and exceed medicine top levels 2cm, then decoct about 20min, during to 200ml, leach medicinal liquid, by twice medicinal liquid hybrid filtering, finally the medicinal liquid boiled is poured in 200ml Packaging Bottle respectively.

Embodiment 2: its crude drug prescription is: Radix Angelicae Sinensis 12g, Semen Persicae 12g, Flos Carthami 9g, Radix Et Rhizoma Rhei 12g, Radix Astragali 12g, Rhizoma Dioscoreae 12g, Jiang Nanxing 9g, Fructus Aurantii Immaturus 6g, Rhizoma Pinelliae Preparatum 9g, Exocarpium Citri Rubrum 6g, Caulis Bambusae In Taenia 4g, Radix Trichosanthis 6g, bubble Squama Manis 6g, Herba Asari 3g, Radix Glycyrrhizae 5g; Its manufacture method, for getting Semen Persicae, rhubarb tablets, uses yellow wine uniform spraying, slightly soak, vexed, with the micro-stir-fry of slow fire, when deepening to color and luster, taking-up cools; All the other medicines are put into medicine pot, add water and exceed medicine top levels 3cm, soak 30min, with 5, Rhizoma Zingiberis Recens, start to boil, first boil with high heat, when then boiling 30min with slow fire, enter Radix Et Rhizoma Rhei, Semen Persicae, continue to endure to about 200ml, after leach medicinal liquid; Reenter water and exceed medicine top levels 2cm, then decoct about 20min, during to 200ml, leach medicinal liquid, by twice medicinal liquid hybrid filtering, finally the medicinal liquid boiled is poured in 200ml Packaging Bottle respectively.

Embodiment 3: its medicine is prepared into liquid and pours into 200ml Packaging Bottle, sooner or later services once after food, each one bottle, generally takes and can cure for 6-9 days.

Embodiment 4: criterion of therapeutical effect

The curative effect determinate standard that evaluation of clinical curative effect standard reference " new Chinese medicine guideline of clinical investigations " (trying) is fixed, two groups of patients all follow up a case by regular visits to 1 year.Recovery from illness: within medication 3d, symptom, sign obviously alleviate, ulcer surface all healed within medication 5d, local causalgia disappears, and follows up a case by regular visits to and does not recur for 1 year; Effective: within medication 5d, symptom, sign disappear, and do not recur, even if recurrent number, degree obviously alleviate after half a year in half a year; Effective: in medication 10d, ulcer reduction of area is little shoals, ulcer quantity reduces, and swells and ache and alleviates, and recurrent number reduces, degree alleviates; Invalid: within medication 10d, symptom, sign are all not improved, even increase the weight of.Effective percentage: [(curing number of cases+effective number of cases+effectively number of cases)/total case load] × 100%.

Embodiment 5: randomly draw treatment patient and effect

1. physical data: treatment 52 routine patients, all from the out-patient in January, 2010 ~ 20013 year March, is divided into two groups at random.Treatment group 26 example, male 11 example, women 15 example; 18 ~ 49 years old age, average 33.1 years old; Medical history 8 months ~ 8 years.Matched group 26 example, male 14 example, women 12 example; 17 ~ 50 years old age, average 38.6 years old; Medical history 6 months ~ 9 years.

2. case selection standard: the permit standard of expectorant stasis of blood knot type recurrent aphtha: ulcer differs in size, and mostly is grain of rice size, oozes out few, substrate is put down, and number 1-3, color is light slightly red, micro-red around, protracted course of disease, recurrent exerbation, often because of tired or not good bringing out of sleeping night, pain is heavy for light night in daytime, doublely sees vexed insomnia, feverish sensation in the palms and soles, dimly red tongue, yellow and thin fur, thready and hesitant pulse person.

3. therapeutic effect: we treat 50 examples altogether, and case all gets rid of oral mucosal injury person caused by Behcet syndrome, syphilis and hand-foot-mouth disease oral mucosal injury.Without the patient of prolonged application corticosteroid, immunosuppressant, immunostimulant; Treatments period did not use other antibiotic medicine, had no the untoward reaction of local and whole body.Treatment group 26 example, recovery from illness 9 example, effective 11 examples, effective 4 examples, invalid 2 examples, effective percentage 92.3%, most long-term therapy 12 days, the shortest 4 days, average 5.5 days.

Embodiment 6: treatment patient cases

Patient, female, 45 years old this year.Henan Province Hebi City stone forest village people.Suffered from aphtha in the February the year before last, very pain, diet is all inconvenient, and spirit is tormented.The sons and daughters of this patient see that she sickly to be tormented by this, seek medical advice everywhere for alleviating her slight illness, but all of no avail.Heard that the treatment aphtha effect of drugs that I develops in conjunction with oneself experience was for many years pretty good afterwards, and determined to look for my examination.After she has drunk the medicine that I prepare for her, result miracle has occurred, mouth has not ached at once, and also can normally have a meal, appetite too increases, and complexion is also much better, and disease is also slowly good.

Patient, man, 36 years old, Hebi City people from Qixian County, Henan Province.Last year has not luckily have aphtha, and that is just tormented by disease pain can't have dinner, and bed has all been reluctant, is more reluctant to go out.He seeks medical advice everywhere, and spent many money, the state of an illness but loses improvement, bad during fashion, and often recurs.In friend's party, friend describes me to him, says that I have developed a kind of medicine and can treat recurrent aphtha.Result he drunk I development medicine, have a meal and had appetite, diet increases gradually, and mouth has not also ached, and patient thanks me very much.

Claims (2)

1. treat a medicine for recurrent aphtha, it is characterized in that its crude drug prescription is: Radix Angelicae Sinensis 10-14g, Semen Persicae 10-14g, Flos Carthami 8-10g, Radix Et Rhizoma Rhei 10-14g, Radix Astragali 10-14g, Rhizoma Dioscoreae 10-14g, Jiang Nanxing 8-10g, Fructus Aurantii Immaturus 5-7g, Rhizoma Pinelliae Preparatum 8-10g, Exocarpium Citri Rubrum 5-7g, Caulis Bambusae In Taenia 3-5g, Radix Trichosanthis 5-7g, bubble Squama Manis 5-7g, Herba Asari 2-4g, Radix Glycyrrhizae 4-6g; Its manufacture method, for getting Semen Persicae, rhubarb tablets, uses yellow wine uniform spraying, slightly soak, vexed, with the micro-stir-fry of slow fire, when deepening to color and luster, taking-up cools; All the other medicines are put into medicine pot, add water and exceed medicine top levels 3cm, soak 30min, with 5, Rhizoma Zingiberis Recens, start to boil, first boil with high heat, when then boiling 30min with slow fire, enter Radix Et Rhizoma Rhei, Semen Persicae, continue to endure to about 200ml, after leach medicinal liquid; Reenter water and exceed medicine top levels 2cm, then decoct about 20min, during to 200ml, leach medicinal liquid, by twice medicinal liquid hybrid filtering, finally the medicinal liquid boiled is poured in 200ml Packaging Bottle respectively.

2. a kind of medicine for the treatment of recurrent aphtha according to claim 1, is characterized in that its crude drug prescription is: Radix Angelicae Sinensis 12g, Semen Persicae 12g, Flos Carthami 9g, Radix Et Rhizoma Rhei 12g, Radix Astragali 12g, Rhizoma Dioscoreae 12g, Jiang Nanxing 9g, Fructus Aurantii Immaturus 6g, Rhizoma Pinelliae Preparatum 9g, Exocarpium Citri Rubrum 6g, Caulis Bambusae In Taenia 4g, Radix Trichosanthis 6g, bubble Squama Manis 6g, Herba Asari 3g, Radix Glycyrrhizae 5g; Its manufacture method, for getting Semen Persicae, rhubarb tablets, uses yellow wine uniform spraying, slightly soak, vexed, with the micro-stir-fry of slow fire, when deepening to color and luster, taking-up cools; All the other medicines are put into medicine pot, add water and exceed medicine top levels 3cm, soak 30min, with 5, Rhizoma Zingiberis Recens, start to boil, first boil with high heat, when then boiling 30min with slow fire, enter Radix Et Rhizoma Rhei, Semen Persicae, continue to endure to about 200ml, after leach medicinal liquid; Reenter water and exceed medicine top levels 2cm, then decoct about 20min, during to 200ml, leach medicinal liquid, by twice medicinal liquid hybrid filtering, finally the medicinal liquid boiled is poured in 200ml Packaging Bottle respectively.