CN104435825A - Oral solution for treating postpartum anemia and preparation method of oral solution for treating postpartum anemia - Google Patents
Oral solution for treating postpartum anemia and preparation method of oral solution for treating postpartum anemia Download PDFInfo
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Abstract
The invention relates to an oral solution for treating postpartum anemia. The effective ingredient of the oral solution comprises the following raw materials: microcos paniculata, codonopsis pilosula, silverweed cinquefoil root, tuber fleeceflower stem, prismatomeris tetrandra, veined inula root, angelica sinensis, radix polygonati officinalis, folia perillae acutae, Chinese date, mnubium incisum, pollen typhae, orchis, rhizoma cimicifugae, lemon and seguin argyreia herb. The oral solution is prepared from properly combined medicinal materials, accords with traditional Chinese medicine and modern medical theory, has the effects of tonifying qi, nourishing blood, tonifying kidney to assist spleen, nourishing yin and lung, nourishing stomach to improve production of body fluid, promoting menstruation flow and activating blood circulation, and has a remarkable curative effect on treatment of postpartum anemia caused by massive hemorrhage after delivery of puerpera. The oral solution is capable of improving body resistance of puerpera, promoting body recovery after delivery of puerpera, is safe, does not have toxic or side effect, has quick response, and is worthy of widely clinical popularization and application.
Description
Technical field
The present invention relates to the field of Chinese medicines, particularly a kind of oral liquid and preparation method being used for the treatment of postpartum anemia.
Background technology
Birth process severe loss of blood, be easy to cause new mother's anemia, anemia seriously can have influence on the physical recovery of new mother and the nutrient health of baby.The generation of postpartum anemia, and the body constitution of new mother, and postpartum hemorrhage too much has very large relation.New mother the suckling of self-recovery and unfavorable baby can be affected, so will early find, early control when the anemia of new mother is serious.
Postpartum anemia can make people's malaise, inappetence, resistance decline, and can also cause the symptoms such as uncomfortable in chest, nervous time serious, and may produce many complication, so once made a definite diagnosis anemia and should treat in time.
When new mother anemia occurs at puerperal, the nutrition of self can not get supplementing, and time weakly, galactopoiesis also can be caused not enough, the iron-holder of milk reduces simultaneously, affects the absorption of baby to nutritional labeling.The new mother that general anemia is serious, carries out breast feeding and often makes baby's malnutrition, and resistance declines, and then causes baby's diarrhoea and infectious disease, affects baby's physique and intelligent development, to healthy particularly unfavorable.Childbirth consumes a lot of energy of new mother, causes physical weakness in puerperal, in this case, if new mother occurs anemia again, inherently cause extend puerperal, physical recovery slows down, new mother's resistance even also can be made to decline, the disease such as obstetric infection, heating occurs.New mother, in puerperal, anemia occurs can cause weak, low grade fever, physical weakness, dizziness, fingernail, lip and eyelid is pale, the symptom such as irritated or melancholy, drowsy, the new mother that anemia is serious also may occur uterine prolapse, puerperal endocrine regulation, the disease such as menostaxis.
Because puerpera is in age of sucking, medication is easy to produce certain side effect to baby, thus the medicine for the treatment of puerpera anemia must safety, effective, have no side effect; Chinese materia medica is as the traditional medicine of China, there is the advantages such as effect is strong, instant effect, lasting medicine, and there is no dependency, drug resistance and toxic and side effects, if therefrom select a kind of Chinese medicine preparation to treat postpartum anemia, will there is very important clinical meaning for postpartum anemia.
Summary of the invention
The invention provides a kind of oral liquid and the preparation method that are used for the treatment of postpartum anemia, selected by Chinese medicine preparation of the present invention, medical material compatibility is suitable, meet Chinese medicine and modern medicine theory, there is benefiting qi and nourishing blood, kidney tonifying help spleen, nourishing YIN and moistening the lung, nourishing the stomach to promote the production of body fluid, effect of restoring menstrual flow and invigorating blood circulation, the treatment of the postpartum anemia caused for factors such as parturient childbirth massive hemorrhage is evident in efficacy, puerpera's passive protective physical fitness can be improved, promote puerpera's physical recovery in puerperal, safe without toxic side effect, instant effect, is worth wide popularization and application clinically.
For achieving the above object, technical scheme of the present invention is implemented as follows:
Be used for the treatment of an oral liquid for postpartum anemia, raw material composition and the parts by weight of making described oral liquid effective ingredient are:
Raw material composition and the parts by weight of making described oral liquid effective ingredient are:
Raw material composition and the parts by weight of making described oral liquid effective ingredient are:
Raw material composition and the parts by weight of making described oral liquid effective ingredient are:
Be used for the treatment of a preparation method for the oral liquid of postpartum anemia, comprise following processing step:
(1) get Folium Microcoris paniculatae, Radix potentillae anserinae, Caulis Polygoni Multiflori, Rhizoma Polygonati Odorati, Folium Perillae, Fructus Jujubae, Herba lagopsis supinae, Pollen Typhae, Herba Orchidis Latifoliae, Rhizoma Cimicifugae and Cortex Argyreiae Seguinii Radicis and put into container, add distilled water and boil extraction 3 times, add 10-15 times amount distilled water immersion 4-5 hour first, heated and boiled 3-4 hour, extract; Second time adds 8-10 times amount distilled water heated and boiled 2-3 hour, extracts; Third time adds 6-8 times amount distilled water heated and boiled 1-2 hour, extracts; Merge extractive liquid, filters, obtains filtrate for subsequent use;
(2) getting wheat bran is placed in the pot of heating, when playing cigarette to pot, adds Radix Codonopsis sheet, stirs to buff, takes out sieve and removes wheat bran, cool, grind into powder, cross 120 order fine powders, for subsequent use;
(3) get Radix Angelicae Sinensis Tabellae, use yellow wine uniform spraying, slightly vexed, put in pot and fry with low baking temperature, take out, cool, grind into powder, cross 140 order fine powders, for subsequent use;
(4) get Fructus Citri Limoniae strand juice, filter, stay juice for subsequent use;
(5) by the filtrate obtained by above-mentioned steps (1) ~ (4), fine powder and juice mixing, and add the distilled water of 10-12 times amount, and after stirring and dissolving is even, heated and boiled 0.5 hour, to less than 60 DEG C, leave standstill 1 hour, filter, obtain filtrate, filtrate fill is sealed up for safekeeping, 121 DEG C of pressure sterilizings 20 minutes, packaging, is the described oral liquid being used for the treatment of postpartum anemia.
The property of medicine of the present invention's Chinese medicine used is as follows:
Folium Microcoris paniculatae: sour in the mouth, light, property is put down; Return spleen channel.Clearing away heat-damp and promoting diuresis, stomach invigorating disappears stagnant.Main cold, fever, jaundice, inappetence, dyspepsia, abdominal distention, has loose bowels, skin infection, centipete bite." book on Chinese herbal medicine asks former " carries: " separate all distention of the abdomen caused by various parasites poison of drug, heat clearing away, removing food stagnancy is eaten, jaundice.”
Radix Codonopsis: sweet in the mouth, property is put down; Return spleen, lung meridian.Strengthening the spleen and tonifying the lung, supplementing QI for promoting the production of body fluid.Main weakness of the spleen and stomach, anorexia and loose stool, limbs fatigue, the deficiency of the lung is breathed with cough, spontaneous perspiration of breathing hard, and feeble QI two loses all cards." Chinese crude drug handbook " carries: " control asthenia internal injury, intestinal cold in the stomach, slide and rush down chronic dysentery, asthma excessive thirst, heating spontaneous perspiration, metrorrhagia, tire produce all diseases.”
Radix potentillae anserinae: sweet in the mouth, hardship, cold in nature; Return spleen, stomach warp.Fill blood, strengthening the spleen and stomach, promoting the production of body fluid to quench thirst.Main diarrhea due to hypofunction of the spleen, after being ill anemia, malnutrition, edema, rheumatic arthralgia." Chinese herbal medicine is commonly used in Tibet " carries: " vigorate qi and replenish the blood, controls insufficiency of the spleen diarrhoea, after being ill anemia, malnutrition for invigorating spleen and reinforcing stomach, promoting the production of body fluid to quench thirst.”
Caulis Polygoni Multiflori: sweet in the mouth, micro-hardship, property is put down; GUIXIN, Liver Channel.Tranquilizing by nourishing the heart, dispels the wind, dredging collateral.Main insomnia, dreaminess, blood deficiency general pain, numbness of the skin, rheumatic arthralgia, rubella pruritus." Shaanxi Chinese herbal medicine " carries: " wind-damp dispelling, the meridian dredging.Control head to sleep, hyperhidrosis, anemia, malasia, the dermatosiss such as scabies." modern medicine study confirmation, Caulis Polygoni Multiflori has calmness and discharge function.
Xanthorrhiza: mildly bitter flavor, cool in nature.Cooling blood for hemostasis, dampness removing jaundice eliminating, the strong muscle of dissipating blood stasis.Cardinal teeth gingival hemorrhage, anemia, hepatitis, rheumatic arthritis, traumatic injury, urinary tract infection.
Radix Inulae Nervosae: acrid in the mouth, hardship, warm in nature.Wind-damp dispelling, the meridian dredging, removing food stagnancy pain relieving.Main rheumatalgia, coldness and pain in the epigastrium, dyspeptic abdominal distention, dysphagic, rheumatism beriberi." choosing of Yunnan Chinese herbal medicine " carries: " wind-damp dispelling, the meridian dredging, removing food stagnancy pain relieving.Treating rheumatic arthritis, lumbago and skelalgia, stomachache, dyspepsia, a fishbone or other bone caught in the throat larynx.”
Radix Angelicae Sinensis: sweet in the mouth, pungent, bitter, warm in nature; Return liver, the heart, spleen channel.Enrich blood, invigorate blood circulation, menstruction regulating and pain relieving, moisturize laxation.The all cards of main blood deficiency, menoxenia, amenorrhea, dysmenorrhea, lump in the abdomen knot is poly-, metrorrhagia, asthenia cold abdominalgia, flaccidity syndrome and arthralgia syndrome, numbness of the skin, dryness of the intestine dyschezia, heavy after bloody dysentery, ulcer sores, injury from falling down." Han Shi doctor is logical " carries: " disease of the main blood system of Radix Angelicae Sinensis, river force of labor just can be attacked, and Qin's force of labor is soft should be mended.The suitable processed with wine of all primary disease, and expectorant solely soaks into Sucus Zingberis, leads the reason that blood returns source, Radix Rehmanniae Preparata is as the same.Blood deficiency is with Radix Ginseng, Halloysitum Rubrum for assistant, and heat in blood is equipped with Radix Rehmanniae, Rhizoma Curcumae Longae, bar a kind of reed mentioned in ancient books, the source of vital function without cease; Accumulation of blood is equipped with Radix Et Rhizoma Rhei, and married woman's shape is fertile, and blood turns to expectorant, and two taste Rhizoma Zingiberis Recens leachings, help with diuretic medicine.Want it, blood medicine is not allowed to give up Radix Angelicae Sinensis, therefore ancient prescription SIWU TANG thinks monarch, and Radix Paeoniae is minister, and Radix Rehmanniae is mitogenetic ripe in helping, and Rhizoma Chuanxiong, for making, is that allusion quotation wants cloud.”
Rhizoma Polygonati Odorati: sweet in the mouth, property is put down; Attach to the lung and stomach meridians.Nourishing YIN and moistening the lung, nourishing the stomach to promote the production of body fluid.Main cough caused by dryness, chronic cough, the dry throat and mouth of calentura cloudy liquid consumption wound, interior-heat is quenched one's thirst, deficiency of YIN diseases caused by exogenous pathogenic factor, dizzy dizzy, muscle arteries and veins spasm and pain." the southern regions of the Yunnan Province book on Chinese herbal medicine " carries: " fill blood, invigorating middle warmer spleen invigorating.”
Folium Perillae: acrid in the mouth, warm in nature; Return lung, spleen, stomach warp.Expelling cold and relieving exterior syndrome, dispersing lung-QI and dissipating phlegm, circulation of qi promoting and in, antiabortive, cowfish Eriocheir sinensis poison.Main exterior syndrome due to wind-cold, cough with copious phlegm, crisp distension, nausea and vomiting, stomachache is vomited and diarrhoea, and nausea is got along well, and gestation is disliked cloudy, and ichthyophagy Eriocheir sinensis is poisoning." detailed outline " carries: " promoting the circulation of QI to alleviate the stagnation in middle-JIAO, expectorant profit lung, and blood, warming middle-JIAO, pain relieving, Dingchuan, antiabortive.”
Fructus Jujubae: sweet in the mouth, warm in nature; Return spleen, stomach warp.Tonifying the spleen and stomach, replenishing QI and blood, tranquilizing mind, adjusts battalion to defend, and the property of medicine.Main weakness of the spleen and stomach, insufficiency of vital energy and blood, anorexia and loose stool, fatigue and weakness, palpitation and insomnia, woman hysteria, disharmony of nutrient QI with defensive QI." not Lu " carries: " invigorating the spleen and replenishing QI, powerful, except unhappy, outstanding under treating the heart, intestinal is out-of-the-way.”
Herba lagopsis supinae: acrid in the mouth, micro-hardship, cold in nature; Return Liver Channel.Nourshing blood and promoting blood circulation, clearing away heat-damp and promoting diuresis.Main menoxenia, the stagnant stomachache of the stasis of blood in puerperal, blood deficiency is dizzy, and it is unsuccessful partly to penetrate, traumatic injury, edema, dysuria, conjunctival congestion and swelling pain, carbuncle sore, chilblain, toothache, erythra pruritus.
Pollen Typhae: sweet in the mouth, micro-pungent, property is put down; Return liver, the heart, spleen channel.Hemostasis, blood stasis dispelling, diuresis.Main haematemesis, spitting of blood, epistaxis, standby dysentery, has blood in stool, metrorrhagia, traumatic hemorrhage, trusted subordinate's pain, and amenorrhea is suffered from abdominal pain, puerperal stasis of blood pain, dysmenorrhea, tumbling and swelling, blood strangury and dry pain, leukorrhagia, congenital deformity of the tongue, aphtha, Ting ear, uncontrolled urination is itched." Japan hanako materia medica " carries: " controlling (putting upside down), to flutter blood vexed, evacuation of pus, and skin ulcer is treated, married woman's leukorrhagia, and menstruation is irregular, vim and vigour cardiac and abdominal pain; pregnant pregnant people's hematochezia fetal abortion, and the credit of blood fortune blood, youngster rests the head on shoot, urinary obstruction, and hemorrhoidal hamorrhage rushes down blood; urticaria toxic swelling, and serious epistaxis is spitted blood, stimulating milk secretion, stopping leak essence, dysentery.Made by blood detumescence life, tonifying blood and arresting bleeding is fried and is used.”
Herba Orchidis Latifoliae: sweet in the mouth, property is put down; GUIXIN, kidney, stomach warp.Tonifying kidney and nourishing yin, invigorating spleen and reinforcing stomach.Main deficiency of YIN consumptive disease heat, irritated thirsty, anorexia, menoxenia." Inner Mongol Chinese herbal medicine " carries: " heart tonifying, the kidney invigorating are promoted the production of body fluid, and quench the thirst, strengthening the spleen and stomach, control irritated thirsty, anorexia, YIN-fluid being insufficient, menoxenia.”
Rhizoma Cimicifugae: acrid in the mouth, sweet, cold nature; Return lung, spleen, large intestine, stomach warp.Heat-clearing and toxic substances removing, delivers rash, ascending up spleen-Qi and Yang.Main epidemic disease fire-toxin, aphtha, pharyngalgia, macule, headache cold and heat, carbuncle sore tumefacting virus, sinking of QI of middle-JIAO, diarrhea due to hypofunction of the spleen, heavy under chronic dysentery, women's leukorrhagia, metrorrhagia." detailed outline " carries: " speckle removing rash, clots absorbing blood are controlled sun and fallen into dizzy fortune, the empty pain of the breast side of body, heavy after chronic diarrhea dysentery, lose turbid, leukorrhagia, metrorrhagia, stranguria with blood, hematochezia, impotence cold foot.”
Fructus Citri Limoniae: sour in the mouth, sweet, cool in nature; Attach to the lung and stomach meridians.Promoting the production of body fluid to quench thirst, stomach function regulating is antiabortive.Main gastric heat impairment of body fluid, heatstroke excessive thirst, inappetence, gastral cavity abdomen painful abdominal mass is swollen, and pulmonary cough is coughed, vomiting during pregnancy." food is examined " carries: " thirsty Liao of slurry drink, can ward off summer-heat.Anemia of pregnant woman should eat, can be antiabortive.”
Cortex Argyreiae Seguinii Radicis: taste is micro-puckery, warm in nature; GUIXIN, lung meridian.Qi-supplementing, blood-engendering, dissipating blood stasis stops blooding.Main blood deficiency is dizzy, fracture, hemorrhage due to internal injury." register planted by Guangxi medicine " carries: " granulation promoting, convergence, clears away heart-fire, lung moistening, cough-relieving for Herb: refute bone, hemostasis.Control internal injury.”
The present invention compared with prior art, has following beneficial effect:
Selected by Chinese medicine preparation of the present invention, medical material compatibility is suitable, meet Chinese medicine and modern medicine theory, there is benefiting qi and nourishing blood, kidney tonifying help spleen, nourishing YIN and moistening the lung, nourishing the stomach to promote the production of body fluid, effect of restoring menstrual flow and invigorating blood circulation, the treatment of the postpartum anemia caused for factors such as parturient childbirth massive hemorrhage is evident in efficacy, puerpera's passive protective physical fitness can be improved, promote puerpera's physical recovery in puerperal, safe without toxic side effect, instant effect, is worth wide popularization and application clinically.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material composition of oral liquid effective ingredient of the present invention and weight are:
The preparation method of oral liquid of the present invention, comprises following processing step:
(1) get Folium Microcoris paniculatae, Radix potentillae anserinae, Caulis Polygoni Multiflori, Rhizoma Polygonati Odorati, Folium Perillae, Fructus Jujubae, Herba lagopsis supinae, Pollen Typhae, Herba Orchidis Latifoliae, Rhizoma Cimicifugae and Cortex Argyreiae Seguinii Radicis and put into container, add distilled water and boil extraction 3 times, add 10-15 times amount distilled water immersion 4-5 hour first, heated and boiled 3-4 hour, extract; Second time adds 8-10 times amount distilled water heated and boiled 2-3 hour, extracts; Third time adds 6-8 times amount distilled water heated and boiled 1-2 hour, extracts; Merge extractive liquid, filters, obtains filtrate for subsequent use;
(2) getting wheat bran is placed in the pot of heating, when playing cigarette to pot, adds Radix Codonopsis sheet, stirs to buff, takes out sieve and removes wheat bran, cool, grind into powder, cross 120 order fine powders, for subsequent use;
(3) get Radix Angelicae Sinensis Tabellae, use yellow wine uniform spraying, slightly vexed, put in pot and fry with low baking temperature, take out, cool, grind into powder, cross 140 order fine powders, for subsequent use;
(4) get Fructus Citri Limoniae strand juice, filter, stay juice for subsequent use;
(5) by the filtrate obtained by above-mentioned steps (1) ~ (4), fine powder and juice mixing, and add the distilled water of 10-12 times amount, and after stirring and dissolving is even, heated and boiled 0.5 hour, to less than 60 DEG C, leave standstill 1 hour, filter, obtain filtrate, filtrate fill is sealed up for safekeeping, 121 DEG C of pressure sterilizings 20 minutes, packaging, is the described oral liquid being used for the treatment of postpartum anemia.
Usage and dosage: oral meal, every day 3 times, each 25ml, within 5 days, be a course for the treatment of, 2 to 5 courses for the treatment of can fully recover, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Embodiment 2
The raw material composition of oral liquid effective ingredient of the present invention and weight are:
The present embodiment oral liquor processing step and usage and dosage identical with embodiment 1.
Embodiment 3
The raw material composition of oral liquid effective ingredient of the present invention and weight are:
The present embodiment oral liquor processing step and usage and dosage identical with embodiment 1.
Embodiment 4
The raw material composition of oral liquid effective ingredient of the present invention and weight are:
The present embodiment oral liquor processing step and usage and dosage identical with embodiment 1.
Clinical data:
1, case selection:
For being used for the treatment of the oral liquid of postpartum anemia, select postpartum anemia patient 180 example to carry out clinical observation, patient is divided into two groups at random, treatment group 90 example, age 20-40 year, 28.7 years old mean age, course of disease 1-90 days, average 32.6 days; Matched group 90 example, age 21-35 year, 28 years old mean age, course of disease 1-100 days, average 31.5 days.Two groups of conditions of patients are basically identical, without significant difference, have comparability, and two groups of patients keep on a diet all on request.
2, treat:
Treatment group patient takes oral liquid of the present invention, oral meal, every day 3 times, and each 25ml 5 days is a course for the treatment of, takes 2 to 5 courses for the treatment of continuously, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding; Matched group takes nourishing blood to tranquillize the mind granule, and by specification is taken, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
3, Outcome measure:
(1) cure: puerpera carries out hematin test, between 110 ~ 150g/l, belong to normal level, patient body recovers good.
(2) take a turn for the better: puerpera's haemachrome value raises, at more than 100g/l.
(3) invalid: haemachrome value is without rising.
4, result:
Treatment group: cure 60 examples, take a turn for the better 26 examples, invalid 4 examples, cure rate 66.7%, total effective rate 95.5%.
Matched group: cure 31 examples, take a turn for the better 23 examples, invalid 36 examples, cure rate 34.4%, total effective rate 60%.
Above result display, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.
5, model case citing:
(1) Hu, female, 24 years old, typist, people from Zaozhuang, Shandong.Patient suffers from chronic anaemia for many years, and postpartum anemia increases the weight of, physical weakness, and malaise is to our hospital, carries out haemachrome and measures lower than 60g/l, belong to anemia to patient.Due to patient is in age of sucking can not drug administration without authorization, after doctor recommends to take 2 courses for the treatment of of oral liquid of the present invention, haemachrome value rises, and continue to take 2 courses for the treatment of of oral liquid of the present invention, Anemia disappears, and patient body recovers normal, follows up a case by regular visits to and has no recurrence.
(2) Chen, female, 27 years old, clothes shop storekeeper, Anshan, liaoning Province people.Patient's iron deficiency anemia in puerperal, blood test Lactoferrin 80g/L pale complexion is gloomy, down in spirits, due to child's suckling, do not dare medicine without authorization, the state of an illness increases the weight of gradually always, after recommending to take 2 courses for the treatment of of oral liquid of the present invention by doctor, haemachrome raises, continue to take 3 courses for the treatment of of oral liquid of the present invention, the state of an illness is fully recovered, and Anemia disappears, patient body recovers, and follows up a case by regular visits to and has no recurrence.
(3) Zhao, female, 30 years old, profession, people from Chengde.After patient puerperal period, always cardiopalmus is had palpitation, and often there is insomnia, postemphasis, the symptoms such as Pa Jibu building just easily occurs soreness of the waist and knees, myasthenia of limbs, have a dizzy spell, after to our hospital, take 2 courses for the treatment of of oral liquid of the present invention, above-mentioned symptom takes a turn for the better, and continue to take 3 courses for the treatment of of oral liquid of the present invention, the state of an illness is fully recovered, Anemia disappears, and follows up a case by regular visits to and has no recurrence.
(4) Xu certain, female, 32 years old, sell, people from Jilin songyuan.Patient's artificial abortion vagina is bled in a large number, postoperatively there is headache, have a dizzy spell, the symptom such as drowsiness is to our hospital, after doctor's diagnosis and treatment, take 2 courses for the treatment of of oral liquid of the present invention, above-mentioned symptom takes a turn for the better, and continues to take 2 courses for the treatment of of oral liquid of the present invention, the state of an illness is fully recovered, have rosy cheeks, Anemia disappears, and follows up a case by regular visits to and has no recurrence.
(5) Wang, female, 29 years old, civil servant, people from Nantong.Patient's postpartum anemia, has a delicate constitution, and often with sore waist and aching in the waist and the back, myasthenia of limbs, has anemia symptom, and often feel tired asthenia.After doctor's diagnosis and treatment, take 2 courses for the treatment of of oral liquid of the present invention, above-mentioned symptom takes a turn for the better, and continue to take 3 courses for the treatment of of oral liquid of the present invention, the state of an illness is fully recovered, and Anemia disappears, and follows up a case by regular visits to and has no recurrence.
(6) Zhang, female, 25 years old, civilian, Zhoushan Of Zhejiang Province people.The symptoms such as having a dizzy spell appears puerperal in patient, be short of physical strength, insufficiency of vital energy and blood, so that cannot normally work, then to our hospital.After doctor's diagnosis and treatment, take 1 course for the treatment of of oral liquid of the present invention, various disease is clearly better, and complexion have also been obtained obvious improvement, and continue to take 2 courses for the treatment of of oral liquid of the present invention, the state of an illness is fully recovered, and Anemia disappears, and work recovers normal, follows up a case by regular visits to and has no recurrence.
Claims (5)
1. be used for the treatment of an oral liquid for postpartum anemia, it is characterized in that: raw material composition and the parts by weight of making described oral liquid effective ingredient are:
Folium Microcoris paniculatae 50-80 part Radix Codonopsis 50-80 part Radix potentillae anserinae 42-72 part Caulis Polygoni Multiflori 42-72 part
Xanthorrhiza 42-72 part Radix Inulae Nervosae 38-66 part Radix Angelicae Sinensis 38-66 part Rhizoma Polygonati Odorati 38-66 part
Folium Perillae 35-60 part Fructus Jujubae 35-60 part Herba lagopsis supinae 32-56 part Pollen Typhae 32-56 part
Herba Orchidis Latifoliae 30-52 part Rhizoma Cimicifugae 25-45 part Fructus Citri Limoniae 25-45 part Cortex Argyreiae Seguinii Radicis 15-35 part.
2. a kind of oral liquid being used for the treatment of postpartum anemia according to claim 1, is characterized in that: raw material composition and the parts by weight of making described oral liquid effective ingredient are:
Folium Microcoris paniculatae 71 parts of Radix Codonopsis 71 parts of Radix potentillae anserinae 63 parts of Caulis Polygoni Multiflori 63 parts
Xanthorrhiza 63 parts of Radix Inulae Nervosaes 59 parts of Radix Angelicae Sinensis 59 portions of Rhizoma Polygonati Odorati 59 parts
Folium Perillae 53 portions of Fructus Jujubaes 53 parts of Herba lagopsis supinaes 50 parts of Pollen Typhaes 50 parts
Herba Orchidis Latifoliae 45 parts of Rhizoma Cimicifugaes 40 portions of Fructus Citri Limoniaes 40 parts of Cortex Argyreiae Seguinii Radicises 28 parts.
3. a kind of oral liquid being used for the treatment of postpartum anemia according to claim 1, is characterized in that: raw material composition and the parts by weight of making described oral liquid effective ingredient are:
Folium Microcoris paniculatae 64 parts of Radix Codonopsis 64 parts of Radix potentillae anserinae 56 parts of Caulis Polygoni Multiflori 56 parts
Xanthorrhiza 56 parts of Radix Inulae Nervosaes 52 parts of Radix Angelicae Sinensis 52 portions of Rhizoma Polygonati Odorati 52 parts
Folium Perillae 47 portions of Fructus Jujubaes 47 parts of Herba lagopsis supinaes 43 parts of Pollen Typhaes 44 parts
Herba Orchidis Latifoliae 40 parts of Rhizoma Cimicifugaes 35 portions of Fructus Citri Limoniaes 35 parts of Cortex Argyreiae Seguinii Radicises 24 parts.
4. a kind of oral liquid being used for the treatment of postpartum anemia according to claim 1, is characterized in that: raw material composition and the parts by weight of making described oral liquid effective ingredient are:
Folium Microcoris paniculatae 57 parts of Radix Codonopsis 57 parts of Radix potentillae anserinae 49 parts of Caulis Polygoni Multiflori 49 parts
Xanthorrhiza 49 parts of Radix Inulae Nervosaes 45 parts of Radix Angelicae Sinensis 45 portions of Rhizoma Polygonati Odorati 45 parts
Folium Perillae 41 portions of Fructus Jujubaes 41 parts of Herba lagopsis supinaes 38 parts of Pollen Typhaes 38 parts
Herba Orchidis Latifoliae 35 parts of Rhizoma Cimicifugaes 30 portions of Fructus Citri Limoniaes 30 parts of Cortex Argyreiae Seguinii Radicises 19 parts.
5. as described in any one of claim 1-4, be used for the treatment of a preparation method for the oral liquid of postpartum anemia, it is characterized in that: comprise following processing step:
(1) get Folium Microcoris paniculatae, Radix potentillae anserinae, Caulis Polygoni Multiflori, Rhizoma Polygonati Odorati, Folium Perillae, Fructus Jujubae, Herba lagopsis supinae, Pollen Typhae, Herba Orchidis Latifoliae, Rhizoma Cimicifugae and Cortex Argyreiae Seguinii Radicis and put into container, add distilled water and boil extraction 3 times, add 10-15 times amount distilled water immersion 4-5 hour first, heated and boiled 3-4 hour, extract; Second time adds 8-10 times amount distilled water heated and boiled 2-3 hour, extracts; Third time adds 6-8 times amount distilled water heated and boiled 1-2 hour, extracts; Merge extractive liquid, filters, obtains filtrate for subsequent use;
(2) getting wheat bran is placed in the pot of heating, when playing cigarette to pot, adds Radix Codonopsis sheet, stirs to buff, takes out sieve and removes wheat bran, cool, grind into powder, cross 120 order fine powders, for subsequent use;
(3) get Radix Angelicae Sinensis Tabellae, use yellow wine uniform spraying, slightly vexed, put in pot and fry with low baking temperature, take out, cool, grind into powder, cross 140 order fine powders, for subsequent use;
(4) get Fructus Citri Limoniae strand juice, filter, stay juice for subsequent use;
(5) by the filtrate obtained by above-mentioned steps (1) ~ (4), fine powder and juice mixing, and add the distilled water of 10-12 times amount, and after stirring and dissolving is even, heated and boiled 0.5 hour, to less than 60 DEG C, leave standstill 1 hour, filter, obtain filtrate, filtrate fill is sealed up for safekeeping, 121 DEG C of pressure sterilizings 20 minutes, packaging, is the described oral liquid being used for the treatment of postpartum anemia.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109091530A (en) * | 2017-06-21 | 2018-12-28 | 中国医学科学院药物研究所 | Perilla leaf extract is preventing or is treating the application in alpastic anemia |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1066788A (en) * | 1992-07-01 | 1992-12-09 | 王勇 | The method for making of body-strengthening nutrient oral liquid and purposes in the Asia |
| CN103479886A (en) * | 2013-10-04 | 2014-01-01 | 潘玉梅 | Traditional Chinese medicinal preparation for treating anemia and preparation method |
-
2014
- 2014-11-17 CN CN201410654695.5A patent/CN104435825A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1066788A (en) * | 1992-07-01 | 1992-12-09 | 王勇 | The method for making of body-strengthening nutrient oral liquid and purposes in the Asia |
| CN103479886A (en) * | 2013-10-04 | 2014-01-01 | 潘玉梅 | Traditional Chinese medicinal preparation for treating anemia and preparation method |
Non-Patent Citations (1)
| Title |
|---|
| 肖兴东等: "贫血的中医辨证诊治", 《中国医药指南》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109091530A (en) * | 2017-06-21 | 2018-12-28 | 中国医学科学院药物研究所 | Perilla leaf extract is preventing or is treating the application in alpastic anemia |
| CN109091530B (en) * | 2017-06-21 | 2021-10-22 | 中国医学科学院药物研究所 | Application of perilla leaf extract in preventing or treating aplastic anemia |
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Application publication date: 20150325 |