CN104491494A - 一种治疗风湿疼痛的外用药物组合物 - Google Patents

一种治疗风湿疼痛的外用药物组合物 Download PDF

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CN104491494A
CN104491494A CN201510018061.5A CN201510018061A CN104491494A CN 104491494 A CN104491494 A CN 104491494A CN 201510018061 A CN201510018061 A CN 201510018061A CN 104491494 A CN104491494 A CN 104491494A
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pharmaceutical composition
pain
treatment
composition
rheumatism
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周华明
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Abstract

本发明公开一种治疗风湿疼痛的外用药物组合物，该组合物由黄芪、川芎、苍术、延胡索、三七、马钱子、续断、白芍、威灵仙、秦艽、杜仲、丝瓜络、鳖甲、天麻等40味原料药组成。本发明药物组合物按照常规工艺加入常规辅料制成临床接受贴膏剂、喷雾剂、软膏剂、擦剂或酊剂。本发明药物组合物具有温经通络，活血化瘀、消肿止痛、驱风除湿，对治疗风湿疼痛具有良好的治疗作用，且无毒副作用。

Description

一种治疗风湿疼痛的外用药物组合物
技术领域
本发明涉及一种药物组合物，特别是涉及一种治疗风湿疼痛的外用药物组合物。
背景技术
风湿痛，其病症属麻痹症一类，中医认为是风和湿两种病邪结合所致的病症。症见有头痛、发热、微汗、恶风、身重、小便不利、骨节酸痛、不能屈伸等。关节病变除有疼痛外尚伴有肿胀和活动障碍，呈发作与缓解交替的慢性病程。由于患者的血液循环不通畅，导致肌肉或者组织所需要的营养无法通过血液循环来输送，致使患者肌肉缺少营养而加速老化变得僵硬，严重的会导致患者肌肉和血管萎缩，部分患者且可出现关节致残和内脏功能衰竭。风湿痹病是由于风寒湿热等外邪入侵，闭阻经络关节，气血运行不畅，主要临床表现为全身关节呈游走性红、肿、重着、疼痛。常指风湿性关节炎。
发明内容
本发明目的在于提供一种治疗风湿疼痛的外用药物组合物。
本发明是通过如下技术方案实现的：
本发明药物组合物的原料药组成为：
本发明药物组合物的原料药组成优选为：
本发明药物组合物的原料药组成优选为：
本发明药物组合物的原料组成优选为：
本发明药物组合物按照常规工艺加入常规辅料制成临床接受的散剂、贴膏剂、喷雾剂、软膏剂、擦剂或酊剂。
本发明药物组合物具有温经通络，活血化瘀、消肿止痛、驱风除湿之功效，对治疗风湿疼痛具有良好的治疗作用，且无毒副作用。
下面实验例用于进一步说明本发明，但不限于本发明。
一、实验例
1、临床观察
本发明散剂(按照实施例1方法制备)治疗风湿疼痛100例，其中男性50例，女性50例。
2、药物选择
治疗组：本发明散剂(按照实施例1方法制备)，30g/袋，一袋/次。
3、诊断标准
①病史：有风寒湿邪的侵袭史。
②症状：有关节或肌肉酸痛，麻木、疼痛，甚至剧痛，活动困难，遇冷病情加重。
③体征：受累关节因疼痛所致功能受限，但活动后减轻，多数病例只痛不肿，少数病例在关节周围轻度肿胀(无红热)。
④x线检查：除少数病例可见软组织肿胀外，一般无骨质改变。
⑤实验室检查：血沉绝大多数正常，少数稍快，抗链球菌溶血素O、类风湿因子、血常规等皆属正常。
⑥预后：缓解期或治愈后受累关节不留畸形，关节功能恢复正常。
4、疗效标准
参照国家中医药管理局1994年实施的《中医病诊断疗效标准》拟定如下：
临床痊愈：中医临床症状、体征消失或基本消失；
显效：中医临床症状、体征明显改变；
有效：中医临床症状、体征均有好转；
无效：中医临床症状、体征均无明显改善；
5、治疗结果
表1治疗风湿疼痛的疗效结果
组别 治疗人数 痊愈 显效 有效 无效 总有效率
治疗组 100 65 20 13 2 98％
6、结论
治疗组贴敷本发明散剂(按照实施例1方法制备)三个疗程(每个疗程4天)，治疗结果显示，本发明治疗组总有效率98％。
实验例二、典型病例
病例1：李某，男，57岁。患者主诉关节肿痛间断发作2年，近1年加重。初起因上呼吸道感染后出现发热，周身关节胀痛，经西医治疗后减轻，但仍反复发作关节肿痛，累及双侧指间、掌指、腕、足趾、踝、膝关节，肿胀疼痛，彻夜不能眠，曾经在外院确诊为类风湿关节炎。就诊时症见：双手近端指间关节、左侧足趾关节红肿疼痛，双腕、双膝关节疼痛，活动受限，不能持物，不能下蹲，晨僵，行走困难(需要搀扶)，畏风怕冷。舌质红苔薄黄，脉弦细。西医诊断：类风湿关节炎活动期；中医诊断：骨痹；辨证：风寒化热，日久伤阴。治法：清热养阴，消肿止痛，祛风通络。通过贴敷本发明散剂(按照实施例1方法制备)一个疗程后(一疗程4天)各个关节疼痛症状明显减轻，夜间可以安然入睡，恶风怕冷减轻，独自步行前来就诊。复诊时关节仍肿胀明显，双手不能握拳，舌脉同前。继续使用一个疗程，关节肿痛缓解，关节功能明显改善，能自主活动，又使用1疗程巩固治疗后完全痊愈。
病例2：王某，女，11岁。患者平素体质较差，易于感冒，2个月前受凉后出现双侧指(趾)间关节对称性肿痛，伴晨僵2小时余，畏寒喜暖，乏力。舌质淡红偏暗，苔薄白，脉沉细略弦。西医诊断：幼年类风湿关节炎。中医诊断：尪痹，肾虚寒盛证。辨证：风寒化热，日久伤阴。治法：补肾散寒，祛风除湿。通过贴本发明贴膏剂(按照实施例2方法制备)，一贴/2天。治疗二个疗程(每疗程4天)，各个关节疼痛症状明显减轻，晨僵已少于半小时，病情明显好转。复诊时舌脉同前。续帖发明膏药1个疗程后完全治愈。
病例3：高某，女，60岁。主诉反复多关节疼痛30年，加重1个月。患者30年前无明显诱因出现双膝关节及足跟疼痛，无肿胀，在外院诊为RA，予止痛药治疗，症状反复发作，1个月前病情加重。刻下：左手第2、3近指关节肿痛，双腕、双肩疼痛，双膝关节肿痛。口干，无口腔溃疡及皮疹，无雷诺现象，自觉畏寒肢冷，恶风、纳差、眠可、二便调。查体：左手第2、3近端指间关节肿胀、压痛明显，局部皮温高，左肘屈曲受限，双膝伸直困难，以右侧为重。舌暗苔黄，脉滑数。西医诊断：类风湿关节炎。中医诊断：痹证，证属气虚湿热，瘀血阻络。治法：祛风散寒除湿，化痰消瘀。通过使用本发明软膏剂(按照实施例3方法制备)治疗二个疗程(每个疗程4天)，患者自觉全身关节疼痛明显好转，纳食转佳，眠安，手能写字，能自由行走。继续使用本发明软膏剂一个疗程后完全治愈。
病例4：王某，女，55岁。患者半年前感受寒湿后出现双手小关节疼痛，自服风湿药酒后，症状加重。平时喜冷。指间关节红肿疼痛，局部发热，得凉则痛减，活动受限，手不能握摄，晨僵3小时，口渴不欲饮，溲黄赤。舌质红，苔黄微腻，脉滑数。西医诊断：类风湿关节炎；中医诊断：痹证；辨证：热毒夹湿，痹阻脉络。治法：清热解毒，利湿宣痹，活血通络。通过使用本发明喷雾剂(按照实施例4方法制备)治疗二个疗程(每个疗程4天)，关节肿痛明显好转，关节功能明显改善，继续治疗一个疗程生活可以完全自理，经检查已基本恢复正常。
具体实施方式
下述实施例均能实现上述实验例的效果。
实施例1散剂
将上述药物按照常规工艺加入常规辅料制成散剂，30g/袋，一袋/次。
实施例2贴膏剂
将上述药物按照常规工艺加入常规辅料制成贴膏剂。
实施例3软膏剂
将上述药物按照常规工艺加入常规辅料制成软膏剂。
实施例4喷雾剂
将上述药物按照常规工艺加入常规辅料制成喷雾剂。
实施例5擦剂
将上述药物按照常规工艺加入常规辅料制成擦剂。
实施例6酊剂
将上述药物按照常规工艺加入常规辅料制成酊剂。

Claims (6)

1.一种治疗风湿疼痛的外用药物组合物，其特征在于，该组合物的原料药组成为：
2.如权利要求1所述的药物组合物，其特征在于，该组合物的原料药组成为：
3.如权利要求1所述的药物组合物，其特征在于，该组合物的原料药组成为：
4.如权利要求3所述的药物组合物，其特征在于，该组合物的原料药组成为：
5.如权利要求1-4之一所述的药物组合物，其特征在于该组合物按照常规工艺加入常规辅料制成临床接受的散剂、贴膏剂、喷雾剂、软膏剂、擦剂或酊剂。
6.如权利要求1-4之一所述的药物组合物在制备治疗风湿疼痛的药物中的应用。
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