CN104491472A - Heat and toxic material clearing preparation for treating esophageal cancer and preparation method of heat and toxic material clearing preparation - Google Patents

Heat and toxic material clearing preparation for treating esophageal cancer and preparation method of heat and toxic material clearing preparation Download PDF

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CN104491472A
CN104491472A CN201410760926.0A CN201410760926A CN104491472A CN 104491472 A CN104491472 A CN 104491472A CN 201410760926 A CN201410760926 A CN 201410760926A CN 104491472 A CN104491472 A CN 104491472A
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李菲
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
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    • A61K35/60—Fish, e.g. seahorses; Fish eggs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288—Taraxacum (dandelion)
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714—Aconitum (monkshood)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A61K36/748—Oldenlandia or Hedyotis
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Abstract

The invention discloses a heat and toxic material clearing preparation for treating esophageal cancer. The heat and toxic material clearing preparation is prepared from the following main raw materials in parts by weight: 10-20 parts of nidus vespae, 9-15 parts of dendrobe, 15-25 parts of dandelion, 3-7 parts of catharanthus roseus, 15-30 parts of sculellaria barbata, 9-16 parts of concha arcae, 8-15 parts of radix phytolaccae, 6-12 parts of patrinia heterophylla, 3-5 parts of borax, 4-6 parts of shortstalk monkshood roots, 9-15 parts of oldenlandia diffusa and 8-12 parts of sciaenid ladders. The heat and toxic material clearing preparation conforms to the traditional Chinese medicine theory for treating esophageal cancer; and through dialectical compatibility, all the traditional Chinese medicine raw materials are complementary in effect and have the effects of relieving exterior syndromes and detoxifying, cooling blood and relieving swelling as well as clearing away heat and purging pathogenic fire. The heat and toxic material clearing preparation can be used for effectively inhibiting the growth of cancer cells, killing the cancer cells to a certain extent and preventing the cancer cells from further dispersing, and is remarkable in curative effect and reliable in effect.

Description

Esophageal carcinoma antipyretic-detoxicant preparation and preparation method
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of esophageal carcinoma antipyretic-detoxicant preparation and preparation method.
Background technology
Esophageal carcinoma is the malignant tumor occurring in epithelium of esophagus tissue, accounts for 2% of all malignant tumor.The whole world about has 200,000 people to die from esophageal carcinoma every year, and China is esophageal carcinoma district occurred frequently, and occupy second because esophageal carcinoma died is only second to gastric cancer, age of onset is many more than 40 years old, and male is more than women.But within less than 40 years old in recent years, send out patient and have growth trend.The exact cause of esophageal carcinoma is fuzzy, and require study discussion.Through the disease that the existing survey data display esophageal carcinoma may be caused by many factors, the cause of disease proposed is as follows: (1) chemical cause of disease: very extensively, can be formed in vivo and in vitro, carcinogenecity is strong for this compounds of nitrosamine and precursor distribution thereof.In the saliva of the meals in district occurred frequently, drinking-water, sauerkraut, even patient, survey content of nitrite Jun Bidifa district high.(2) biological agent: fungus, in the grain of some district occurred frequently, in the upper digestive tract of Patients With Carcinoma of Esophagus or in the esophageal carcinoma specimen of excision, all can isolate multiple fungus, wherein some fungus has carcinogenesis.Some fungus can impel the formation of nitrosamine, more promotes the generation of cancerous protuberance.(3) some trace element is lacked: the content in grain, vegetable, drinking-water such as molybdenum, ferrum, zinc, fluorine, selenium is on the low side.(4) be deficient in vitamin: the A that is deficient in vitamin, vitamin B2, vitamin C and animal proteinum, fresh vegetables, fruit Deficiency of Intake.(5) factors such as cigarette, wine, heat food, hot drink, oral cavity be unclean: drink ardent spirits for a long time, have a liking for smoking, food is really up to the mark, overheated, it is too fast to take food, and causes that chronic stimulation, inflammation, wound or oral cavity are unclean, dental caries etc. all may be relevant with the generation of the esophageal carcinoma.(6) esophageal cancer genetic predisposing factor.
For cancer patient, the most fearful displaced no more than cancerous cell, here is three kinds of common esophageal carcinoma routes of metastasis.The first is hematogenous metastasis, and transfer is general to be occurred more late, and the hematogenous metastasis of esophageal carcinoma is more rare, and common metastasis site has stomach, liver, lung, kidney, pleura, peritoneum, adrenal gland and pancreas etc., with liver and lung more common.The second is direct diffusion and the infiltration of esophagus inwall, the other epithelium bottom cell carcinogenesis of corpus carcinosus or formation cancer in situ, it is one of esophageal carcinoma diffusion into the surface mode, mainly involving position is mucous membrane of esophagus and tela submucosa, it is also the place of shifting the earliest, because mucous membrane of esophagus and tela submucosa are without placenta percreta and have abundant lymphatic vessel, can through esophagus lamina propria or tela submucosa lymphatic vessel direct invasion adjacent organs, as lung, trachea-bronchial epithelial cell, pleura, pericardium, aorta etc.Upper Esophageal Carcinoma can invade throat, trachea and neck soft, even invades bronchus, forms bronchus one esophageal fistula; Also can invade thoracic duct, azygos vein, hilus pulumonis and lung tissue, part can invade aorta and form esophagus-aortic sinus fistula, causes massive hemorrhage and lethal.Hypomere esophageal carcinoma often can involve cardia and pericardium.It is generally acknowledged that to be directly diffused in epimere cancer more, hypomere cancer is less.Spread naked eyes under most of mucosa and see Non Apparent Abnormality, microscopy just can be observed.Along the tuberosity of lymph diffusion, like second primary carcinoma, the diffusion way in this esophageal wall, general distance primary tumor 5-6cm, therefore the length of excision will suitably be selected, whether this contacts directly in successful surgery.The third is lymphatic metastasis, the lymphatic metastasis of esophagus is more common, account for 2/3 of case, occur general to be comparatively early mainly seen in esophagus other lymph node, hilar lymph node, supraclavicular lymph nodes and cardual lymph nodes, shift with low differentiated squamous-cell carcinomas and undifferentiated carcinoma common, metastasis site is relevant with esophagus lymphatic drainage direction, epimere esophageal carcinoma can be invaded by esophagus, after larynx, throat depth and supraclavicular lymph nodes, as there is hoarseness, how due to metastatic lymph node compressing recurrent laryngeal nerve.Often there is esophagus side or hilar lymph node transfer in stage casing esophageal carcinoma, also can shift up or down.
At present, the medicine for the treatment of esophageal carcinoma also has a lot, for the problems referred to above, publication number CN 103417810 A (application number 201310295242.3) patent document discloses a kind of Chinese medicine for the treatment of esophageal carcinoma, and it is made up of the raw material of following weight portion: Haematitum 25-35 part, Herba Agrimoniae 12-25 part, Radix Angelicae Sinensis 5-15 part, Rhizoma Dioscoreae 10-20 part, Radix Trichosanthis 10-20 part, Radix Asparagi 10-20 part, Radix Glycyrrhizae 10-20 part.Publication number CN 101036732 A (application number 200610044404.6) patent document discloses a kind of Chinese medicine preparation and compound method thereof for the treatment of esophageal carcinoma; the medicine pill that it is made primarily of the crude drug of following weight portion, Lapis Micae Aureus 40-70 part, Borax 60-85 part, Sal Ammoniacus 60-85 part, Cornu Saigae Tataricae 25-50 part, Borneolum Syntheticum 65-85 part, Chalcanthitum 50-75 part, Lignum Aquilariae Resinatum 70-90 part, Venenum Bufonis 55-75 part, Squama Manis 65-85 part, Calculus Bovis 50-70 part, Moschus 35-55 part, Oleum Sesami 150-220 part.Publication number CN 101249235 A(application number 200810050571.0) patent document discloses a kind of Chinese medicine for the treatment of esophageal carcinoma and preparation method thereof, comprise Chinese medicine A and Chinese medicine B, wherein Chinese medicine A is made up of the crude drug of following weight portion: Borneolum Syntheticum 180-220, Calculus Bovis 20-30, Venenum Bufonis 0.9-1.5, Lignum Aquilariae Resinatum 60-70, Moschus 1.0-3.0, Sal Nitri 65-90, Sal Ammoniacus 25-30, Margarita 60-80, Lapis Chloriti 160-250, Resina Ferulae 12-18, Radix Notoginseng 40-55; Chinese medicine B is made up of the crude drug of following weight portion: Radix Angelicae Sinensis 45-60, Radix Paeoniae Alba 45-60, Flos Carthami 40-50, Rhizoma Chuanxiong 40-60, Rhizoma Sparganii 40-60, Rhizoma Curcumae 40-60, Rhizoma Pinelliae 35-55, Radix Aucklandiae 35-50, Fructus Amomi 20-30, Rhizoma Corydalis 40-60, Fructus Aurantii 40-60, Endoconcha Sepiae 70-90, Herba Scutellariae Barbatae 100-200, Herba Hedyotidis Diffusae 100-200, Pseudobulbus Cremastrae seu Pleiones 70-80, Aloe 70-90, Radix Ginseng 30-60, Rhizoma Atractylodis Macrocephalae 70-80, Radix Rehmanniae 70-80, Radix Glycyrrhizae 30-60.
Also there is the defects such as curative effect is undesirable in the prior art comprising above-mentioned patent documentation in treatment esophageal carcinoma, doctor trained in Western medicine treats esophageal carcinoma, for early stage and the patient of the mid-early stage method adopting operation more, and for the patient of later stage and middle and late stage to the method mitigate the disease adopting chemotherapy, operative treatment torments to patient body bringing huge pain, convalescent period is long, and the diffusion controlling cancerous cell might not be reached, and chemotherapy causes side effect very to human body, comprise nausea and vomiting, alopecia, tired, sensation of oppression over the chest with shortness of breath, nervous cardiopalmus, and, also a lot of normal cells can be killed while anticancer growth, body immunity is easily caused to decline.
Summary of the invention
For the deficiencies in the prior art, an object of the present invention is to provide a kind of esophageal carcinoma antipyretic-detoxicant preparation, adopt Chinese crude drug comparatively common in the localities as raw material, each raw material of Chinese medicine, through dialectical compatibility, has toxic removing of inducing sweat, removing heat from blood detumescence and effect of clearing away heat-fire.Can the growth of effective anticancer, kill cancerous cell to a certain extent, stop the further diffusion of cancerous cell.Another object of the present invention is just to provide the preparation method of above-mentioned esophageal carcinoma antipyretic-detoxicant preparation.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
Esophageal carcinoma antipyretic-detoxicant preparation, takes off the primary raw material stating weight proportion and is prepared from: Nidus Vespae 10-20 part; Herba Dendrobii 9-15 part; Herba Taraxaci 15-25 part; Herba Catharanthi Rosei 3-7 part; Herba Scutellariae Barbatae 15-30 part; Concha Arcae 9-16 part; Radix Phytolaccae 8-15 part; Radix Patriniae heterophyllae 6-12 part; Borax 3-5 part; Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 4-6 part; Herba Hedyotidis Diffusae 9-15 part; Shishou Air Bladder pseudosciaenae seu Acipenser 8-12 part.
Esophageal carcinoma antipyretic-detoxicant preparation, preferred scheme is, takes off the primary raw material stating weight proportion and is prepared from: Nidus Vespae 13-17 part; Herba Dendrobii 11-13 part; Herba Taraxaci 18-22 part; Herba Catharanthi Rosei 4-6 part; Herba Scutellariae Barbatae 20-25 part; Concha Arcae 11-14 part; Radix Phytolaccae 10-13 part; Radix Patriniae heterophyllae 8-10 part; Borax 3.5-4.5 part; Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 4.5-5.5 part; Herba Hedyotidis Diffusae 11-13 part; Shishou Air Bladder pseudosciaenae seu Acipenser 9-11 part.
Esophageal carcinoma antipyretic-detoxicant preparation, the scheme be more preferably is, takes off the primary raw material stating weight proportion and is prepared from: Nidus Vespae 15 parts; Herba Dendrobii 12 parts; Herba Taraxaci 20 parts; Herba Catharanthi Rosei 5 parts; Herba Scutellariae Barbatae 22 parts; Concha Arcae 12 parts; Radix Phytolaccae 11 parts; Radix Patriniae heterophyllae 9 parts; Borax 4 parts; Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 5 parts; Herba Hedyotidis Diffusae 12 parts; 10 parts, Shishou Air Bladder pseudosciaenae seu Acipenser.
Present invention also offers the preparation method above-mentioned esophageal carcinoma antipyretic-detoxicant preparation being made pharmaceutically acceptable pill, decoction, powder and thick paste agent.
The preparation method of described esophageal carcinoma antipyretic-detoxicant preparation pill, step is as follows:
(1) cleaned by Nidus Vespae, shred, be placed in iron pan, slow fire roasting, to sallow taking-up, is ground for fine powder, crosses 200-300 mesh sieve (preferred, to cross 230-270 mesh sieve, be more preferably, cross 250 mesh sieves);
(2) Shishou Air Bladder pseudosciaenae seu Acipenser is cleaned, drain, explode to crisp with Oleum sesami, take out, pulverize, cross 140-180 mesh sieve (preferred, to cross 150-170 mesh sieve, be more preferably, cross 160 mesh sieves);
(3) get clean Borax, be calcined to loose in smokeless stove fire, taking-up is dried in the air cool, smashes;
(4) Radix Phytolaccae and upper one of snow are highly cut into slices, be placed in non iron container soak 1-2 days (preferred, soak 1.2-1.8 days, be more preferably, soak 1.5 days), get the coarse sand of uniform particles cleaning, put in marmite be heated to 80-100 DEG C (preferred, be heated to 85-95 DEG C, be more preferably, be heated to 90 DEG C), add the medical material soaked, stir-fry, make medical material thermally equivalent, stop heating when frying Huang micro-to surface, sieve removes the grains of sand;
(5) Concha Arcae is smashed, be placed in marmite, decoct 40-60 minute (preferably, decoct 45-55 minute, be more preferably, decoct 50 minutes), add step (3) gains, step (4) gains, Herba Dendrobii, Herba Taraxaci, Herba Catharanthi Rosei, Herba Scutellariae Barbatae, Radix Patriniae heterophyllae and Herba Hedyotidis Diffusae, continue decoction twice, each decoction 20-40 minute is (preferred, each decoction 25-35 minute, be more preferably, each decoction 30 minutes), twice filtrate merges, gained filtrate is concentrated into 1/2 of original volume, add step (1) and step (2) gains, mixing, concentrated (45 DEG C) to relative density is that 1.10-1.20(is preferred, being concentrated into relative density is 1.13-1.17, be more preferably, being concentrated into relative density is 1.15), add starch, mixing, make the namely loose soft material that hands pinches agglomerating pressure, cross 80-120 mesh sieve (preferred 90-110 mesh sieve, be more preferably 100 mesh sieves), dry, pulverize, obtain medicated powder,
(6) Mel is placed in pot, tempers with slow fire, wait Mel to endure to thick, mix the medicated powder of step (5) gained, fully mix into ointment thoroughly, (preferred, the diameter of pill is 3-5mm to make pill by traditional Chinese medical science tradition pill method, be more preferably, the diameter of pill is 4mm), obtain pill.
Instructions of taking: each 6-8 ball, every day 3 times, 20 days courses for the treatment of.
According to preparation method recited above, preferred scheme is: the consumption of step (6) Mel is that the 10%-20%(of medicated powder quality is preferred, and the consumption of Mel is 15% of medicated powder quality).
The preparation method of described esophageal carcinoma antipyretic-detoxicant preparation decoction, step is as follows:
(1) cleaned by Nidus Vespae, shred, be placed in iron pan, slow fire roasting, to sallow taking-up, is ground for fine powder, crosses 200-300 mesh sieve (preferred, to cross 230-270 mesh sieve, be more preferably, cross 250 mesh sieves);
(2) Shishou Air Bladder pseudosciaenae seu Acipenser is cleaned, drain, explode to crisp with Oleum sesami, take out, pulverize, cross 140-180 mesh sieve (preferred, to cross 150-170 mesh sieve, be more preferably, cross 160 mesh sieves);
(3) get clean Borax, be calcined to loose in smokeless stove fire, taking-up is dried in the air cool, smashes;
(4) Radix Phytolaccae and upper one of snow are highly cut into slices, be placed in non iron container soak 1-2 days (preferred, soak 1.2-1.8 days, be more preferably, soak 1.5 days), get the coarse sand of uniform particles cleaning, put in marmite be heated to 80-100 DEG C (preferred, be heated to 85-95 DEG C, be more preferably, be heated to 90 DEG C), add the medical material soaked, stir-fry, make medical material thermally equivalent, stop heating when frying Huang micro-to surface, sieve removes the grains of sand;
(5) Concha Arcae is smashed, be placed in marmite, decoct 40-60 minute (preferably, decoct 45-55 minute, be more preferably, decoct 50 minutes), add step (3) gains, step (4) gains, Herba Dendrobii, Herba Taraxaci, Herba Catharanthi Rosei, Herba Scutellariae Barbatae, Radix Patriniae heterophyllae and Herba Hedyotidis Diffusae, continue decoction twice, each decoction (preferably, decocts 25-35 minute in 20-40 minute at every turn, be more preferably, each decoction 30 minutes), twice filtrate merges
(6) step (5) gained filtrate is concentrated into 1/2 of original volume, adds step (1)-(2) gains and simple syrup, mixing, within high temperature sterilization 20-40 minute, (preferred, high temperature sterilization 25-35 minute, is more preferably, high temperature sterilization 30 minutes), sterile packaged.
According to preparation method recited above, preferred scheme is: the consumption of step (6) simple syrup is that the 6%-10%(of concentrated solution quality is preferred, and the consumption of simple syrup is 8% of concentrated solution quality).
Instructions of taking: each 60-100ml, every day 3 times, 20 days courses for the treatment of.
The preparation method of described esophageal carcinoma antipyretic-detoxicant preparation powder, step is as follows:
(1) cleaned by Nidus Vespae, shred, be placed in iron pan, slow fire roasting, to sallow taking-up, is ground for fine powder, crosses 200-300 mesh sieve (preferred, to cross 230-270 mesh sieve, be more preferably, cross 250 mesh sieves);
(2) Shishou Air Bladder pseudosciaenae seu Acipenser is cleaned, drain, explode to crisp with Oleum sesami, take out, pulverize, cross 140-180 mesh sieve (preferred, to cross 150-170 mesh sieve, be more preferably, cross 160 mesh sieves);
(3) get clean Borax, be calcined to loose in smokeless stove fire, taking-up is dried in the air cool, smashes;
(4) Radix Phytolaccae and upper one of snow are highly cut into slices, be placed in non iron container soak 1-2 days (preferred, soak 1.2-1.8 days, be more preferably, soak 1.5 days), get the coarse sand of uniform particles cleaning, put in marmite be heated to 80-100 DEG C (preferred, be heated to 85-95 DEG C, be more preferably, be heated to 90 DEG C), add the medical material soaked, stir-fry, make medical material thermally equivalent, stop heating when frying Huang micro-to surface, sieve removes the grains of sand;
(5) Concha Arcae is smashed, be placed in marmite, decoct 40-60 minute (preferably, decoct 45-55 minute, be more preferably, decoct 50 minutes), add step (3) gains, step (4) gains, Herba Dendrobii, Herba Taraxaci, Herba Catharanthi Rosei, Herba Scutellariae Barbatae, Radix Patriniae heterophyllae and Herba Hedyotidis Diffusae, continue decoction twice, each decoction 20-40 minute is (preferred, each decoction 25-35 minute, be more preferably, each decoction 30 minutes), twice filtrate merges, concentrated (45 DEG C) to relative density is that 1.10-1.20(is preferred, being concentrated into relative density is 1.13-1.17, be more preferably, being concentrated into relative density is 1.15), add starch, mixing, make the namely loose soft material that hands pinches agglomerating pressure, cross 80-120 mesh sieve (preferred 90-110 mesh sieve, be more preferably 100 mesh sieves), dry, pulverize, obtain medicated powder,
(6) step (1), step (2) and step (5) gains are mixed, obtain powder.
Instructions of taking: each 10-15g, with the warm boiled water of 35-40 DEG C, every day 3 times, 20 days courses for the treatment of.
The preparation method of described esophageal carcinoma antipyretic-detoxicant preparation thick paste agent, step is as follows:
(1) cleaned by Nidus Vespae, shred, be placed in iron pan, slow fire roasting, to sallow taking-up, is ground for fine powder, crosses 200-300 mesh sieve (preferred, to cross 230-270 mesh sieve, be more preferably, cross 250 mesh sieves);
(2) Shishou Air Bladder pseudosciaenae seu Acipenser is cleaned, drain, explode to crisp with Oleum sesami, take out, pulverize, cross 140-180 mesh sieve (preferred, to cross 150-170 mesh sieve, be more preferably, cross 160 mesh sieves);
(3) get clean Borax, be calcined to loose in smokeless stove fire, taking-up is dried in the air cool, smashes;
(4) Radix Phytolaccae and upper one of snow are highly cut into slices, be placed in non iron container soak 1-2 days (preferred, soak 1.2-1.8 days, be more preferably, soak 1.5 days), get the coarse sand of uniform particles cleaning, put in marmite be heated to 80-100 DEG C (preferred, be heated to 85-95 DEG C, be more preferably, be heated to 90 DEG C), add the medical material soaked, stir-fry, make medical material thermally equivalent, stop heating when frying Huang micro-to surface, sieve removes the grains of sand;
(5) Concha Arcae is smashed, be placed in marmite, decoct 40-60 minute (preferably, decoct 45-55 minute, be more preferably, decoct 50 minutes), add step (3) gains, step (4) gains, Herba Dendrobii, Herba Taraxaci, Herba Catharanthi Rosei, Herba Scutellariae Barbatae, Radix Patriniae heterophyllae and Herba Hedyotidis Diffusae, continue decoction twice, within 20-40 minute, (preferred, each decoction 25-35 minute, is more preferably in each decoction, each decoction 30 minutes), twice filtrate merges;
(6) step (5) gained filtrate is concentrated into 1/2 of original volume, add step (1)-(2) gains, mixing, add sorbic acid, concentrated (25 DEG C) to relative density is that the thick paste of 1.20-1.30 (preferably, is concentrated into the thick paste that relative density is 1.23-1.27, is more preferably, be concentrated into the thick paste that relative density is 1.25), sterile packaged.
According to preparation method recited above, preferred scheme is: the consumption of step (6) sorbic acid is that the 0.02%-0.04%(of concentrated solution quality is preferred, and the consumption of sorbic acid is 0.03% of concentrated solution quality).
Instructions of taking: each 10-15g, with the warm boiled water of 35-40 DEG C, every day 3 times, 20 days courses for the treatment of.
Esophageal carcinoma antipyretic-detoxicant preparation of the present invention, meets the theory of the traditional Chinese medical science about treatment esophageal carcinoma, and each raw material of Chinese medicine, through dialectical compatibility, coordinates with paving mutually at work, has toxic removing of inducing sweat, removing heat from blood is subsided a swelling and effect of clearing away heat-fire.Can the growth of effective anticancer, kill cancerous cell to a certain extent, stop the further diffusion of cancerous cell.It is evident in efficacy, reliable effect.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
The pharmacological effect of each crude drug is respectively:
Nidus Vespae: sweet in the mouth, property is put down.Return liver, stomach, kidney channel.For the nest of Vespidae insecticide yellow star long foot wasp or multiple nearly edge insecticide, they are made up of numerous orthohexagonal Cera Flava nest room.In Nidus Vespae except Apis, also have their larva, and store honey and bee pollen.Containing dew room oil, Cera Flava, resin, various saccharides, vitamin and inorganic salt etc.There is effect of wind-expelling pain-stopping, the detumescence of rose poison, killing parasites for relieving itching.For pathogenic wind-warm arthralgia pain, wind carious pain, carbuncle malignant boil, scrofula, mouthpiece swells and ache, anal fistula, rubella pruritus, skin stubborn dermatitis.
Herba Dendrobii: sweet in the mouth, cold nature.Return stomach, kidney channel.For the fresh or dry stem of orchid gold silver five dry measure used in former times, iron sheet building stones or Herba Dendrobii oculati and allied species thereof.There is reinforcing stomach reg fluid, effect of nourishing YIN and clearing away heat.Lose for cloudy impairment of body fluid, xerostomia excessive thirst, lack of appetite is retched, deficiency-heat after being ill. poor vision.
Herba Taraxaci: bitter in the mouth, sweet, cold in nature.Return liver, stomach warp.For feverfew Herba Taraxaci, alkali ground Herba Taraxaci or the dry herb belonging to several plants together.There is heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, effect of inducing diuresis for treating stranguria syndrome.For furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, enterodynia, jaundice due to damp-heat, the puckery pain of pyretic stranguria.
Herba Catharanthi Rosei: mildly bitter flavor, cool in nature.Return liver, kidney two warp.For the herb of apocynaceae plant Herba Catharanthi Rosei.Plant containing indoles alkaloid more than 70, comprise vinblastine, vincristine, lochnericine, lochnericine, remove acetyl vindorosine, vincaleucoblastine, Changchun Buddhist nun is fixed, lochnerinine etc.Containing more than 70 kind of alkaloid in Herba Catharanthi Rosei, a kind of natural good medicine of anti-curing cancers, wherein vinblastine and vincristine have certain curative effect to pernicious refreshing tumor, lymphosarcoma and acute leukemias etc. such as treatment pulmonary carcinoma, are apply maximum anticancer vegetable drug sources in the world.There is effect of removing heat from blood blood pressure lowering, tranquillizing and allaying excitement, detoxicating and fighting cancer, heat clearing away suppressing the hyperactive liver.For hypertension, burning hot wound, malignant lymphoma, chorionic epithelioma, monocytic leukemia, multiple cancerous protuberance, hypertension, carbuncle sore tumefacting virus, scald.
Herba Scutellariae Barbatae: acrid in the mouth, hardship, cold in nature.Return lung, liver, kidney channel.For the dry herb of labiate Herba Scutellariae Barbatae.There is heat-clearing and toxic substances removing, effect of blood stasis dispelling diuresis.For furuncle swelling toxin, laryngopharynx swelling and pain, venom, falls and flutters the pain of injury, edema, jaundice.
Concha Arcae: salty in the mouth, property is put down.Return lung, stomach, Liver Channel.For the shell of Carnis Arca inflata section animal Scapharca subcrenata, Tegillarca granosa or Scapharca broughtonii.There is expectorant blood stasis dispelling, hard masses softening and resolving, effect of relieving gastric hyperacidity to alleviate stomachache.For the long-pending knot of pertinacious phlegm, sticky difficulty is coughed up, goiter, scrofula ， mass in the abdomen mass in the abdomen, stomachache pantothenic acid.
Radix Phytolaccae: bitter in the mouth, cold in nature, poisonous.Return lung, spleen, kidney, large intestine channel.For the dry root of Phytolaccaceae plant pokeweed or pokeroot.There is detumescence of relieving oedema or abdominal distension through diuresis or purgation, smoothening secretion, effect of detoxicating and resolving stagnation of pathogens.For edema distension, constipation and anuresis; External treatment carbuncle sore tumefacting virus.
Radix Patriniae heterophyllae: acrid in the mouth, warm in nature.GUIXIN, liver two warp.For the root of Valerianaceae plant Radix Patriniae Scabrae, Radix Patriniae Scabrae.Root and rhizome is containing volatile oil, and wherein main constituent has: β-Flos Caryophylli alkene, α-Humuleno, decahydro-4,8,8-trimethyl-9-methylene-1,4-methylene azulene, 3,7,11-trimethyls-1,3,6,10-12 carbon tetraene, ζ-cubebol, β-selinene etc., identify 26 kinds of compositions altogether.There is promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain, promoting blood circulation and hemostasis, hold back effect of liver dampness.For blood stasis type metrorrhagia.
Borax: be crystallization or the white crystalline powder of semi-transparent clear, odorless, have efflorescence properties, aqueous solution shows alkaline reaction.This product is easily molten in boiling water or glycerol, dissolves in water, insoluble in ethanol.Chemical composition is sodium tetraborate, containing Na 2b 4o 710H 2o should be 99.0%-105.0%.
Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani): bitter in the mouth, pungent, warm in nature.Very toxic.Return Liver Channel.For the dried root of Ranunculaceae aconitum plant aconitum brachypodum Radix aconiti szechenyiani Aconitum nagarum var.lasiandrum W.T.Wang, another name Radix Aconiti Brachypodi Radix Aconiti Szechenyiani, Herba Achilleae, Radix aconiti szechenyiani, Radix aconiti szechenyiani, three and half.Its containing Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) first, second, third, fourth, penta, oneself, heptan is plain, aconitine, hypaconitine, 3-deoxyaconitine, 3-acetylaconitine, penduline, laxiconitine, anepline etc.There is expelling wind and removing dampness, effect of anti-inflammatory analgesic.For rheumatic ostalgia, tumbling and swelling and toothache, neuralgia, rheumatalgia, traumatic injury and toothache, postoperative pain, late tumor pain.
Herba Hedyotidis Diffusae: mildly bitter flavor, micro-sweet, cold nature.GUIXIN, liver, spleen channel.For the dry herb of Maguireothamnus speciosus Herba Hedyotidis Diffusae.Herb containing rubichloric acid., rubichloric acid. acid, remove the acid of acetate rubichloric acid., all square rafter glycoside acid, Herba Paederiae time glycoside, Herba Paederiae time glycoside methyl ester, 6-O-p-hydroxyl cinnamyl Herba Paederiae time glycoside methyl ester, 6-O-p-methoxyl group cinnamyl Herba Paederiae time glycoside methyl ester, 6-O-Resina Ferulae acyl Herba Paederiae time glycoside methyl ester, 2-methyl-3-hydroxyanthraquinone, 2-methyl-3-methoxy anthraquinone etc.There is heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, effect of inducing diuresis to remove edema.For laryngopharynx swelling and pain, dyspnea and cough due to lung-heat, the puckery pain of pyretic stranguria, jaundice due to damp-heat, venom, skin ulcer swells hot carbuncle.
Shishou Air Bladder pseudosciaenae seu Acipenser: be the Air Bladder pseudosciaenae seu Acipenser of Sciaenidae animal Carnis Pseudosciaenae or Carnis Pseudosciaenae.Carnis Pseudosciaenae has another name called Channa argus, mainly lives in the seabed of high concentration of sediment, and major part crosses group life.Carnis Pseudosciaenae mainly with shell-fish and Mollusca for food.Every 100 grams of large and small Channa argus contain respectively: moisture 81,79 grams; 17.6,16.7 grams, protein; 0.8,3.5 gram, fat; Ash 0.9,0.9 gram; Calcium 33,43 milligrams; 135,127 milligrams, phosphorus; Ferrum 0.9,1.2 milligrams; Thiamine 0.01,0.01 milligram; 0.10,0.14 milligram, riboflavin; Nicotinic acid 0.8,0.9 milligram.Every 1 kilogram of fresh Carnis Pseudosciaenae is containing iodine 120 microgram.
embodiment 1esophageal carcinoma antipyretic-detoxicant preparation, takes off and states primary raw material and be prepared from (getting 50g for every part): Nidus Vespae 10 parts; Herba Dendrobii 9 parts; Herba Taraxaci 15 parts; Herba Catharanthi Rosei 3 parts; Herba Scutellariae Barbatae 15 parts; Concha Arcae 9 parts; Radix Phytolaccae 8-15 part; Radix Patriniae heterophyllae 6 parts; Borax 3 parts; Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 4 parts; Herba Hedyotidis Diffusae 9 parts; 8 parts, Shishou Air Bladder pseudosciaenae seu Acipenser.
The preparation method of above-mentioned esophageal carcinoma antipyretic-detoxicant preparation pill, step is as follows:
(1) cleaned by Nidus Vespae, shred, be placed in iron pan, slow fire roasting, to sallow taking-up, is ground for fine powder, crosses 250 mesh sieves;
(2) Shishou Air Bladder pseudosciaenae seu Acipenser is cleaned, drain, explode to crisp with Oleum sesami, take out, pulverize, cross 160 mesh sieves;
(3) get clean Borax, be calcined to loose in smokeless stove fire, taking-up is dried in the air cool, smashes;
(4) Radix Phytolaccae and upper one of snow are highly cut into slices, be placed in non iron container and soak 2 days, get the coarse sand of uniform particles cleaning, put in marmite and be heated to 90 DEG C, add the medical material soaked, stir-fry, make medical material thermally equivalent, stop heating when frying Huang micro-to surface, sieve removes the grains of sand;
(5) Concha Arcae is smashed, be placed in marmite, decoct 50 minutes, add step (3) gains, step (4) gains, Herba Dendrobii, Herba Taraxaci, Herba Catharanthi Rosei, Herba Scutellariae Barbatae, Radix Patriniae heterophyllae and Herba Hedyotidis Diffusae, continue decoction twice, each decoction 30 minutes, twice filtrate merges, gained filtrate is concentrated into 1/2 of original volume, add step (1) and step (2) gains, mixing, concentrated (45 DEG C) to relative density is the thick paste of 1.15, add relative to thick paste quality 10% starch, mixing, make the namely loose soft material that hands pinches agglomerating pressure, cross 100 mesh sieves, dry, pulverize, obtain medicated powder,
(6) by relative to medicated powder quality 15% Mel be placed in pot, temper with slow fire, wait Mel to endure to thick, mix the medicated powder of step (5) gained, fully mix into ointment thoroughly, make by the traditional Chinese medical science tradition pill method pill that diameter is 4mm, obtain pill.
Instructions of taking: each 6-8 ball, every day 3 times, 20 days courses for the treatment of.
model case one:chu XX, man, 68 years old, retired professor, people from Yanggu County, Liaocheng of Shandong Province.Patient swallows food difficulty when occurring having a meal before 2 years, pain removes examination in hospital, carries out biopsy, be diagnosed as esophageal carcinoma and carry out operative treatment through boroscopy.Postoperative patient continues chemicotherapy, simultaneously recovering aid treatment, but has occurred the diffusion of cancerous cell, and this allows Mr. Chu and household thereof, and some is panic, so start to make some inquiries about.
The curative effect asking about esophageal carcinoma antipyretic-detoxicant preparation of the present invention is afterwards fine, so buy 1 the course for the treatment of embodiment 2 gained esophageal carcinoma antipyretic-detoxicant preparation pill, when swallowing food after having taken, pharyngeal pain sense alleviates to some extent, and spirit, muscle power are recovered all to some extent.See this curative effect, after continuing to take 2 courses for the treatment of, remove examination in hospital, be surprised to find cancerous cell diffusion to be unexpectedly brought under control, show indices in check after half a year and all belong to normal, this allows Mr. Chu say with feeling: " my disease is not cured in operation, and this Chinese medicine preparation has cured my cancer unexpectedly; simply dare not believe, but in fact be really like this! " at present, the life of Mr. Chu complete recovery of health people.
embodiment 2esophageal carcinoma antipyretic-detoxicant preparation, takes off and states primary raw material and be prepared from (getting 60g for every part): Nidus Vespae 13 parts; Herba Dendrobii 11 parts; Herba Taraxaci 18 parts; Herba Catharanthi Rosei 4 parts; Herba Scutellariae Barbatae 20 parts; Concha Arcae 11 parts; Radix Phytolaccae 10 parts; Radix Patriniae heterophyllae 8 parts; Borax 3.5 parts; Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 4.5 parts; Herba Hedyotidis Diffusae 11 parts; 9 parts, Shishou Air Bladder pseudosciaenae seu Acipenser.
The preparation method of above-mentioned esophageal carcinoma antipyretic-detoxicant preparation decoction, step is as follows:
(1) cleaned by Nidus Vespae, shred, be placed in iron pan, slow fire roasting, to sallow taking-up, is ground for fine powder, crosses 250 mesh sieves;
(2) Shishou Air Bladder pseudosciaenae seu Acipenser is cleaned, drain, explode to crisp with Oleum sesami, take out, pulverize, cross 160 mesh sieves;
(3) get clean Borax, be calcined to loose in smokeless stove fire, taking-up is dried in the air cool, smashes;
(4) Radix Phytolaccae and upper one of snow are highly cut into slices, be placed in non iron container and soak 2 days, get the coarse sand of uniform particles cleaning, put in marmite and be heated to 90 DEG C, add the medical material soaked, stir-fry, make medical material thermally equivalent, stop heating when frying Huang micro-to surface, sieve removes the grains of sand;
(5) Concha Arcae is smashed, be placed in marmite, decoct 50 minutes, add step (3) gains, step (4) gains, Herba Dendrobii, Herba Taraxaci, Herba Catharanthi Rosei, Herba Scutellariae Barbatae, Radix Patriniae heterophyllae and Herba Hedyotidis Diffusae, continue decoction twice, each decoction 30 minutes, twice filtrate merges
(6) step (5) gained filtrate is concentrated into 1/2 of original volume, add step (1)-(2) gains and relative to concentrated solution quality 8% simple syrup, mixing, high temperature sterilization 30 minutes, sterile packaged.
Instructions of taking: each 60-100ml, every day 3 times, 20 days courses for the treatment of.
model case two:king XX, man, 67 years old, peasant, Zibo City of Shandong Province from Yiyuan County.Without swallowing food difficulty when occurring having a meal under obvious inducement, the symptoms such as cough, remove examination in hospital.After CT examination, be diagnosed as esophageal carcinoma.Children accompany Mr. Wang to go hospitalize, doctor says it is middle and advanced stage, can only chemotherapy, during chemotherapy one month, hair eyebrow has just fallen substantially, and nausea and vomiting be can't have dinner, can disease worsening always, chest pain, having a meal, it is more difficult to swallow, doctor also say be normal reaction adhering to that treatment is gone down, Mr. Wang is can not adhered to really, just leaves hospital and has gone home.Be in recuperation time, children also ask about everywhere, and in the date of seeking medical advice everywhere, encounter a ward mate, be esophageal carcinoma, it is much better that other does not make chemotherapy yet, can eat meal, and one asks the Chinese medicine just known and taken a kind of esophageal carcinoma antipyretic-detoxicant preparation.
So its son just have purchased the embodiment 2 gained esophageal carcinoma antipyretic-detoxicant preparation decoction of 2 courses for the treatment of immediately, after having taken, just feel all right by many, chest pain, asthma, cough all alleviate, and still have discomfort when just having a meal.So after continuing to take 2 courses for the treatment of, make Mr. Wang one glad, unexpectedly normally can eat meal, having a meal drinks water does not know how many times all byer force than before, with the same one day breakfast, lunch and dinner of normal person, can cross the life of normal person completely.
embodiment 3esophageal carcinoma antipyretic-detoxicant preparation, takes off and states primary raw material and be prepared from (getting 40g for every part): Nidus Vespae 17 parts; Herba Dendrobii 13 parts; Herba Taraxaci 22 parts; Herba Catharanthi Rosei 6 parts; Herba Scutellariae Barbatae 25 parts; Concha Arcae 14 parts; Radix Phytolaccae 13 parts; Radix Patriniae heterophyllae 10 parts; Borax 4.5 parts; Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 5.5 parts; Herba Hedyotidis Diffusae 13 parts; 11 parts, Shishou Air Bladder pseudosciaenae seu Acipenser.
The preparation method of above-mentioned esophageal carcinoma antipyretic-detoxicant preparation powder, step is as follows:
(1) cleaned by Nidus Vespae, shred, be placed in iron pan, slow fire roasting, to sallow taking-up, is ground for fine powder, crosses 250 mesh sieves;
(2) Shishou Air Bladder pseudosciaenae seu Acipenser is cleaned, drain, explode to crisp with Oleum sesami, take out, pulverize, cross 160 mesh sieves;
(3) get clean Borax, be calcined to loose in smokeless stove fire, taking-up is dried in the air cool, smashes;
(4) Radix Phytolaccae and upper one of snow are highly cut into slices, be placed in non iron container and soak 2 days, get the coarse sand of uniform particles cleaning, put in marmite and be heated to 90 DEG C, add the medical material soaked, stir-fry, make medical material thermally equivalent, stop heating when frying Huang micro-to surface, sieve removes the grains of sand;
(5) Concha Arcae is smashed, be placed in marmite, decoct 50 minutes, add step (3) gains, step (4) gains, Herba Dendrobii, Herba Taraxaci, Herba Catharanthi Rosei, Herba Scutellariae Barbatae, Radix Patriniae heterophyllae and Herba Hedyotidis Diffusae, continue decoction twice, each decoction 30 minutes, twice filtrate merges, and concentrated (45 DEG C) to relative density is 1.15, add relative to concentrated solution quality 8% starch, mixing, make the namely loose soft material that hands pinches agglomerating pressure, cross 100 mesh sieves, dry, pulverize, obtain medicated powder;
(6) step (1), step (2) and step (5) gains are mixed, obtain powder.
Instructions of taking: each 10-15g, every day 3 times, with the warm boiled water of 35-40 DEG C, 20 days courses for the treatment of.
model case three:zhu XX, man, 53 years old, people from Lixia District, Jinan City, Shandong Province.Occurred the malaise symptoms such as difficulty of having a meal before 3 years, just having started Mr. Zhu thinks it is pharyngitis, has just taken a little coldrex and antibiotic medicine, but takes after one week still without any alleviation.So remove examination in hospital, make a definite diagnosis esophageal carcinoma middle and late stage, doctor, according to the state of an illness, does not give and implements operative treatment, select chemotherapy, after chemotherapy one wheat harvesting period, and DeGrain.Tell about according to Mr. Zhu: tumor is large as mushroom, myasthenia of limbs, can not eat, when doing gastroscopy, pipe all under do not enter.
Recognized that the effect of esophageal carcinoma antipyretic-detoxicant preparation of the present invention was fine afterwards, and had a lot of patient to take the rear state of an illness and obtain controlling even to fully recover.So buy the embodiment 3 gained esophageal carcinoma antipyretic-detoxicant preparation powder of 2 courses for the treatment of, taken rear sensory symptoms and alleviated to some extent, tumor reduces to some extent, and spirit, muscle power also make moderate progress.So continue to take 3 courses for the treatment of, go examination in hospital unexpectedly to show tumor and disappear, physical recovery is normal.After 1 year, call-on back by phone is carried out to Mr. Zhu, learn that the health of Mr. Zhu is always fine, do not occur the abnormal problems such as transfer, recurrence.
embodiment 4esophageal carcinoma antipyretic-detoxicant preparation, takes off and states primary raw material and be prepared from (getting 20g for every part): Nidus Vespae 15 parts; Herba Dendrobii 12 parts; Herba Taraxaci 20 parts; Herba Catharanthi Rosei 5 parts; Herba Scutellariae Barbatae 22 parts; Concha Arcae 12 parts; Radix Phytolaccae 11 parts; Radix Patriniae heterophyllae 9 parts; Borax 4 parts; Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 5 parts; Herba Hedyotidis Diffusae 12 parts; 10 parts, Shishou Air Bladder pseudosciaenae seu Acipenser.
The preparation method of above-mentioned esophageal carcinoma antipyretic-detoxicant preparation thick paste agent, step is as follows:
(1) cleaned by Nidus Vespae, shred, be placed in iron pan, slow fire roasting, to sallow taking-up, is ground for fine powder, crosses 250 mesh sieves;
(2) Shishou Air Bladder pseudosciaenae seu Acipenser is cleaned, drain, explode to crisp with Oleum sesami, take out, pulverize, cross 160 mesh sieves;
(3) get clean Borax, be calcined to loose in smokeless stove fire, taking-up is dried in the air cool, smashes;
(4) Radix Phytolaccae and upper one of snow are highly cut into slices, be placed in non iron container and soak 2 days, get the coarse sand of uniform particles cleaning, put in marmite and be heated to 90 DEG C, add the medical material soaked, stir-fry, make medical material thermally equivalent, stop heating when frying Huang micro-to surface, sieve removes the grains of sand;
(5) Concha Arcae is smashed, be placed in marmite, decoct 50 minutes, add step (3) gains, step (4) gains, Herba Dendrobii, Herba Taraxaci, Herba Catharanthi Rosei, Herba Scutellariae Barbatae, Radix Patriniae heterophyllae and Herba Hedyotidis Diffusae, continue decoction twice, each decoction 30 minutes, twice filtrate merges;
(6) step (5) gained filtrate is concentrated into 1/2 of original volume, adds step (1)-(2) gains, mixing, adds sorbic acid, and concentrated (25 DEG C) to relative density is the thick paste of 1.25, sterile packaged.
Instructions of taking: each 10-15g, with the warm boiled water of 35-40 DEG C, every day 3 times, 20 days courses for the treatment of.
test example:for the examination of curative effect of embodiment 4 gained esophageal carcinoma antipyretic-detoxicant preparation thick paste agent, we have done toxicity test and clinical trial, and concrete condition is as follows:
toxicity test acute toxicity testselect SPF level kunming mice, raise in square transparent mouse cage, the drinking-water that guarantee is sufficient and food, raise 2-3 days before experiment, to adapt to experimental situation, and observes its normal growth activity and health status.Need the feeding room to mice, cage tool, drinking bottle etc. to carry out disinfection before raising, before administration, fasting can't help water 12 hours.Select the mice 20 of normal health, male and female half and half, body weight 18-22g, ensure female not producing, without pregnant.Gastric perfusion needle is used to carry out gavage to mice: to be melted by embodiment 4 gained esophageal carcinoma antipyretic-detoxicant preparation thick paste agent warm water, gastric perfusion needle is inserted by animal bicker, general depth of needle 2.5-3cm, every mouse stomach 0.3ml medicinal liquid, the reaction of close observation mice after administration, observes 15 days, and experimental animal does not find poisoning manifestations, without dead, dissect obviously not abnormal, judge that esophageal carcinoma antipyretic-detoxicant preparation of the present invention is to the nontoxic level in the true border of Mouse Acute Toxicity.
long term toxicity testselect SPF level kunming mice, raise in square transparent mouse cage, the drinking-water that guarantee is sufficient and food, raise 2-3 days before experiment, to adapt to experimental situation, and observes its normal growth activity and health status.The feeding room to mice, cage tool, drinking bottle etc. is needed to carry out disinfection before raising.Before administration, fasting can't help water 12 hours.Select the mice 20 of normal health, male and female half and half, body weight 18-22g, same guarantee is female does not produce, without pregnant.Take embodiment 4 gained esophageal carcinoma antipyretic-detoxicant preparation thick paste agent warm water to melt, every mice controls dosage 1g every day, continuous use 7 weeks, drug withdrawal was observed after 3 weeks, weighs weekly once, can be observed amount of drinking water appetite all normal during administration, body weight increases, without dead or moribund animals, the index such as hair, behavior, defecation, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of mice all has no significant effect, and internal organs naked eyes do not find difference change.Histological indications shows, medication 7 weeks and drug withdrawal are after 3 weeks, and Organs of Mice all without obviously changing, illustrates that esophageal carcinoma antipyretic-detoxicant preparation of the present invention is very little to toxicity after mice long-term prescription, does not also have difference reaction, application safety after drug withdrawal.
clinical trial:in order to verify the curative effect of the esophageal carcinoma antipyretic-detoxicant preparation thick paste agent of embodiment 4 gained, We conducted contrast test.Experiment sieving esophageal cancer patients 260 people (wherein early stage patient 28 people, mid-term patient 94 people, patients with terminal 138 people), be divided into matched group and experimental group randomly, wherein experimental group has 160 people, and matched group has 100 people.Experimental group: take the agent of embodiment 4 gained esophageal carcinoma antipyretic-detoxicant preparation thick paste, each 10-15g, with the warm boiled water of 35-40 DEG C, every day 3 times, 20 days courses for the treatment of; Matched group: adopt other treatment scheme, such as operation or chemotherapy etc.Our every days same equal time, medication under square one, and the health of observing simultaneously, recording every group patient.Curative effect situation criterion: effective: after 5 courses for the treatment of, pain disappears, tumor disappearance or obviously reduce, and appetite is normal, energetic, recovers normal work and life.Take a turn for the better: after 5 courses for the treatment of, pain obviously alleviates, appetite increases, and the mental status is recovered to some extent, and tumor reduces to some extent, but still needs continual cure.Invalid: after 5 courses for the treatment of, symptom does not have any improvement, the state of an illness continues development.Wherein effectively comprise effective and take a turn for the better.The Comparison of therapeutic of matched group and experimental group, concrete condition is as shown in table 1:
Table 1
efficacy analysis:as can be seen from Table 1, no matter be for esophageal carcinoma early stage patient, esophageal carcinoma patient in mid-term or advanced esophageal cancer patient, the curative effect taking the agent of the embodiment of the present invention 4 gained esophageal carcinoma antipyretic-detoxicant preparation thick paste is far away all than the good effect using other treatment mode.Wherein, from effective percentage, for early stage patient, take the agent of embodiment 4 gained esophageal carcinoma antipyretic-detoxicant preparation thick paste up to 94.4%, and use other treatment mode be only 80%; For patient in mid-term, take the effective percentage of embodiment 4 gained esophageal carcinoma antipyretic-detoxicant preparation thick paste agent up to 96.7%, and use other treatment mode be only 75.8%; For patients with terminal, take the effective percentage of embodiment 4 gained esophageal carcinoma antipyretic-detoxicant preparation thick paste agent up to 93.8%, and use other modes be only 68.4%.And take the obvious effective rate of embodiment 4 gained esophageal carcinoma antipyretic-detoxicant preparation thick paste agent and improvement rate is also high than the obvious effective rate and improvement rate that adopt other treatment mode.Experiment shows to take the agent of embodiment 4 gained esophageal carcinoma antipyretic-detoxicant preparation thick paste compared with employing other treatment mode, and its curative effect increases substantially, and cure rate is high, and inefficiency is low.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (10)

1. esophageal carcinoma antipyretic-detoxicant preparation, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: Nidus Vespae 10-20 part; Herba Dendrobii 9-15 part; Herba Taraxaci 15-25 part; Herba Catharanthi Rosei 3-7 part; Herba Scutellariae Barbatae 15-30 part; Concha Arcae 9-16 part; Radix Phytolaccae 8-15 part; Radix Patriniae heterophyllae 6-12 part; Borax 3-5 part; Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 4-6 part; Herba Hedyotidis Diffusae 9-15 part; Shishou Air Bladder pseudosciaenae seu Acipenser 8-12 part.
2. esophageal carcinoma antipyretic-detoxicant preparation according to claim 1, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: Nidus Vespae 13-17 part; Herba Dendrobii 11-13 part; Herba Taraxaci 18-22 part; Herba Catharanthi Rosei 4-6 part; Herba Scutellariae Barbatae 20-25 part; Concha Arcae 11-14 part; Radix Phytolaccae 10-13 part; Radix Patriniae heterophyllae 8-10 part; Borax 3.5-4.5 part; Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 4.5-5.5 part; Herba Hedyotidis Diffusae 11-13 part; Shishou Air Bladder pseudosciaenae seu Acipenser 9-11 part.
3. esophageal carcinoma antipyretic-detoxicant preparation according to claim 1, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: Nidus Vespae 15 parts; Herba Dendrobii 12 parts; Herba Taraxaci 20 parts; Herba Catharanthi Rosei 5 parts; Herba Scutellariae Barbatae 22 parts; Concha Arcae 12 parts; Radix Phytolaccae 11 parts; Radix Patriniae heterophyllae 9 parts; Borax 4 parts; Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 5 parts; Herba Hedyotidis Diffusae 12 parts; 10 parts, Shishou Air Bladder pseudosciaenae seu Acipenser.
4., according to the arbitrary described esophageal carcinoma antipyretic-detoxicant preparation of claim 1-3, it is characterized in that, this esophageal carcinoma antipyretic-detoxicant preparation is made pharmaceutically acceptable pill, and preparation method is:
(1) cleaned by Nidus Vespae, shred, be placed in iron pan, slow fire roasting, to sallow taking-up, is ground for fine powder, crosses 200-300 mesh sieve (preferred, to cross 230-270 mesh sieve, be more preferably, cross 250 mesh sieves);
(2) Shishou Air Bladder pseudosciaenae seu Acipenser is cleaned, drain, explode to crisp with Oleum sesami, take out, pulverize, cross 140-180 mesh sieve (preferred, to cross 150-170 mesh sieve, be more preferably, cross 160 mesh sieves);
(3) get clean Borax, be calcined to loose in smokeless stove fire, taking-up is dried in the air cool, smashes;
(4) Radix Phytolaccae and upper one of snow are highly cut into slices, be placed in non iron container soak 1-2 days (preferred, soak 1.2-1.8 days, be more preferably, soak 1.5 days), get the coarse sand of uniform particles cleaning, put in marmite be heated to 80-100 DEG C (preferred, be heated to 85-95 DEG C, be more preferably, be heated to 90 DEG C), add the medical material soaked, stir-fry, make medical material thermally equivalent, stop heating when frying Huang micro-to surface, sieve removes the grains of sand;
(5) Concha Arcae is smashed, be placed in marmite, decoct 40-60 minute (preferably, decoct 45-55 minute, be more preferably, decoct 50 minutes), add step (3) gains, step (4) gains, Herba Dendrobii, Herba Taraxaci, Herba Catharanthi Rosei, Herba Scutellariae Barbatae, Radix Patriniae heterophyllae and Herba Hedyotidis Diffusae, continue decoction twice, each decoction 20-40 minute is (preferred, each decoction 25-35 minute, be more preferably, each decoction 30 minutes), twice filtrate merges, gained filtrate is concentrated into 1/2 of original volume, add step (1) and step (2) gains, mixing, concentrated (45 DEG C) to relative density is that 1.10-1.20(is preferred, being concentrated into relative density is 1.13-1.17, be more preferably, being concentrated into relative density is 1.15), add starch, mixing, make the namely loose soft material that hands pinches agglomerating pressure, cross 80-120 mesh sieve (preferred 90-110 mesh sieve, be more preferably 100 mesh sieves), dry, pulverize, obtain medicated powder,
(6) Mel is placed in pot, tempers with slow fire, wait Mel to endure to thick, mix the medicated powder of step (5) gained, fully mix into ointment thoroughly, (preferred, the diameter of pill is 3-5mm to make pill by traditional Chinese medical science tradition pill method, be more preferably, the diameter of pill is 4mm), obtain pill.
5. the preparation method of esophageal carcinoma antipyretic-detoxicant preparation pill according to claim 4, is characterized in that: the consumption of step (6) Mel is that the 10%-20%(of medicated powder quality is preferred, and the consumption of Mel is 15% of medicated powder quality).
6., according to the arbitrary described esophageal carcinoma antipyretic-detoxicant preparation of claim 1-3, it is characterized in that, this esophageal carcinoma antipyretic-detoxicant preparation is made pharmaceutically acceptable decoction, and preparation method is:
(1) cleaned by Nidus Vespae, shred, be placed in iron pan, slow fire roasting, to sallow taking-up, is ground for fine powder, crosses 200-300 mesh sieve (preferred, to cross 230-270 mesh sieve, be more preferably, cross 250 mesh sieves);
(2) Shishou Air Bladder pseudosciaenae seu Acipenser is cleaned, drain, explode to crisp with Oleum sesami, take out, pulverize, cross 140-180 mesh sieve (preferred, to cross 150-170 mesh sieve, be more preferably, cross 160 mesh sieves);
(3) get clean Borax, be calcined to loose in smokeless stove fire, taking-up is dried in the air cool, smashes;
(4) Radix Phytolaccae and upper one of snow are highly cut into slices, be placed in non iron container soak 1-2 days (preferred, soak 1.2-1.8 days, be more preferably, soak 1.5 days), get the coarse sand of uniform particles cleaning, put in marmite be heated to 80-100 DEG C (preferred, be heated to 85-95 DEG C, be more preferably, be heated to 90 DEG C), add the medical material soaked, stir-fry, make medical material thermally equivalent, stop heating when frying Huang micro-to surface, sieve removes the grains of sand;
(5) Concha Arcae is smashed, be placed in marmite, decoct 40-60 minute (preferably, decoct 45-55 minute, be more preferably, decoct 50 minutes), add step (3) gains, step (4) gains, Herba Dendrobii, Herba Taraxaci, Herba Catharanthi Rosei, Herba Scutellariae Barbatae, Radix Patriniae heterophyllae and Herba Hedyotidis Diffusae, continue decoction twice, each decoction (preferably, decocts 25-35 minute in 20-40 minute at every turn, be more preferably, each decoction 30 minutes), twice filtrate merges
(6) step (5) gained filtrate is concentrated into 1/2 of original volume, adds step (1)-(2) gains and simple syrup, mixing, within high temperature sterilization 20-40 minute, (preferred, high temperature sterilization 25-35 minute, is more preferably, high temperature sterilization 30 minutes), sterile packaged.
7. the preparation method of esophageal carcinoma antipyretic-detoxicant preparation decoction according to claim 6, is characterized in that: the consumption of step (6) simple syrup is that the 6%-10%(of concentrated solution quality is preferred, and the consumption of simple syrup is 8% of concentrated solution quality).
8., according to the arbitrary described esophageal carcinoma antipyretic-detoxicant preparation of claim 1-3, it is characterized in that, this esophageal carcinoma antipyretic-detoxicant preparation is made pharmaceutically acceptable powder, and preparation method is:
(1) cleaned by Nidus Vespae, shred, be placed in iron pan, slow fire roasting, to sallow taking-up, is ground for fine powder, crosses 200-300 mesh sieve (preferred, to cross 230-270 mesh sieve, be more preferably, cross 250 mesh sieves);
(2) Shishou Air Bladder pseudosciaenae seu Acipenser is cleaned, drain, explode to crisp with Oleum sesami, take out, pulverize, cross 140-180 mesh sieve (preferred, to cross 150-170 mesh sieve, be more preferably, cross 160 mesh sieves);
(3) get clean Borax, be calcined to loose in smokeless stove fire, taking-up is dried in the air cool, smashes;
(4) Radix Phytolaccae and upper one of snow are highly cut into slices, be placed in non iron container soak 1-2 days (preferred, soak 1.2-1.8 days, be more preferably, soak 1.5 days), get the coarse sand of uniform particles cleaning, put in marmite be heated to 80-100 DEG C (preferred, be heated to 85-95 DEG C, be more preferably, be heated to 90 DEG C), add the medical material soaked, stir-fry, make medical material thermally equivalent, stop heating when frying Huang micro-to surface, sieve removes the grains of sand;
(5) Concha Arcae is smashed, be placed in marmite, decoct 40-60 minute (preferably, decoct 45-55 minute, be more preferably, decoct 50 minutes), add step (3) gains, step (4) gains, Herba Dendrobii, Herba Taraxaci, Herba Catharanthi Rosei, Herba Scutellariae Barbatae, Radix Patriniae heterophyllae and Herba Hedyotidis Diffusae, continue decoction twice, each decoction 20-40 minute is (preferred, each decoction 25-35 minute, be more preferably, each decoction 30 minutes), twice filtrate merges, concentrated (45 DEG C) to relative density is that 1.10-1.20(is preferred, being concentrated into relative density is 1.13-1.17, be more preferably, being concentrated into relative density is 1.15), add starch, mixing, make the namely loose soft material that hands pinches agglomerating pressure, cross 80-120 mesh sieve (preferred 90-110 mesh sieve, be more preferably 100 mesh sieves), dry, pulverize, obtain medicated powder,
(6) step (1), step (2) and step (5) gains are mixed, obtain powder.
9., according to the arbitrary described esophageal carcinoma antipyretic-detoxicant preparation of claim 1-3, it is characterized in that, this esophageal carcinoma antipyretic-detoxicant preparation is made pharmaceutically acceptable thick paste agent, and preparation method is:
(1) cleaned by Nidus Vespae, shred, be placed in iron pan, slow fire roasting, to sallow taking-up, is ground for fine powder, crosses 200-300 mesh sieve (preferred, to cross 230-270 mesh sieve, be more preferably, cross 250 mesh sieves);
(2) Shishou Air Bladder pseudosciaenae seu Acipenser is cleaned, drain, explode to crisp with Oleum sesami, take out, pulverize, cross 140-180 mesh sieve (preferred, to cross 150-170 mesh sieve, be more preferably, cross 160 mesh sieves);
(3) get clean Borax, be calcined to loose in smokeless stove fire, taking-up is dried in the air cool, smashes;
(4) Radix Phytolaccae and upper one of snow are highly cut into slices, be placed in non iron container soak 1-2 days (preferred, soak 1.2-1.8 days, be more preferably, soak 1.5 days), get the coarse sand of uniform particles cleaning, put in marmite be heated to 80-100 DEG C (preferred, be heated to 85-95 DEG C, be more preferably, be heated to 90 DEG C), add the medical material soaked, stir-fry, make medical material thermally equivalent, stop heating when frying Huang micro-to surface, sieve removes the grains of sand;
(5) Concha Arcae is smashed, be placed in marmite, decoct 40-60 minute (preferably, decoct 45-55 minute, be more preferably, decoct 50 minutes), add step (3) gains, step (4) gains, Herba Dendrobii, Herba Taraxaci, Herba Catharanthi Rosei, Herba Scutellariae Barbatae, Radix Patriniae heterophyllae and Herba Hedyotidis Diffusae, continue decoction twice, within 20-40 minute, (preferred, each decoction 25-35 minute, is more preferably in each decoction, each decoction 30 minutes), twice filtrate merges;
(6) step (5) gained filtrate is concentrated into 1/2 of original volume, add step (1)-(2) gains, mixing, add sorbic acid, concentrated (25 DEG C) to relative density is that the thick paste of 1.20-1.30 (preferably, is concentrated into the thick paste that relative density is 1.23-1.27, is more preferably, be concentrated into the thick paste that relative density is 1.25), sterile packaged.
10. the preparation method of esophageal carcinoma antipyretic-detoxicant preparation thick paste according to claim 9 agent, is characterized in that: the consumption of step (6) sorbic acid is that the 0.02%-0.04%(of concentrated solution quality is preferred, and the consumption of sorbic acid is 0.03% of concentrated solution quality).
CN201410760926.0A 2014-12-13 2014-12-13 Heat and toxic material clearing preparation for treating esophageal cancer and preparation method of heat and toxic material clearing preparation Pending CN104491472A (en)

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