CN104491446A

CN104491446A - Fast bleeding-stopping spray

Info

Publication number: CN104491446A
Application number: CN201410844058.4A
Authority: CN
Inventors: 刘春蕾; 王玉
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-12-30
Filing date: 2014-12-30
Publication date: 2015-04-08

Abstract

The invention belongs to the technical field of traditional Chinese medicines and particularly relates to fast bleeding-stopping spray. The fast bleeding-stopping spray is prepared from the following traditional Chinese medicine raw materials in parts by weight: 3-8 parts of radix scutellariae, 10-15 parts of hairyvein agrimony, 5-10 parts of golden cypress, 3-8 parts of coptis chinensis, 1-3 parts of radix sophorae tonkinensis, 3-8 parts of fritillary bulb, 3-8 parts of indigo naturalis, 1-3 parts of borneol, 3-8 parts of rheum officinale, 3-8 parts of menthol, 3-8 parts of knotted flower phyla herb, 3-8 parts of wintercreeper, 3-8 parts of keels, 3-8 parts of bletilla striata, 5-10 parts of madder, 3-8 parts of cuttle bones and 3-5 parts of radix glycyrrhizae which are prepared into spray. The fast bleeding-stopping spray can be used for quickly rescuing for a bleeding condition, and lowering a death rate caused by the wound.

Description

A kind of quick-acting haemostatic powder spray

Technical field

The invention belongs to field of traditional Chinese medicine technology, particularly a kind of quick-acting haemostatic powder spray.

Background technology

Blood in adult body has 4000-4500ml, accounts for about 8% of human body TBW.In general, the hemorrhage of minor cut or wound can be suppressed by the coagulation function of blood self and some additional nursing interventions; If but lose blood when reaching 20% or more, and will blood pressure drops, there is the serious symptoms such as shock; Blood loss is more nearly just in peril of one's life to more than 40%.So hemorrhage time, to process in time, avoid bleeding profusely.

Emergency haemostatic (Life-Saving Rapid Hemostatic Agent, LSRHA) is an emerging field in the world, develops mainly for the outer damaging the spleen and stomach situation that The blood streamed down.At present, the research about LSRHA is just at the early-stage abroad, at home in, the emergency survival hemostasia products of severe bleeding is few.According to the statistics of Ministry of Public Health, annual all kinds of injury occurs about 200,000,000 person-times, and the number that wherein injures accounts for about 9% of total toll, occupies cause of death prostatitis.After extensive wound, severe loss of blood is the biggest factor causing died of wounds, and the people of about 67% dies from uncontrollable losing blood.Therefore, if can control in time the hemorrhage of the wounded in war, vehicle accident, natural disaster and daily life urgent rescue, then greatly can reduce mortality rate, save more life.

Chinese patent (CN102133421A) discloses a kind of quick-acting haemostatic powder wound dressing and preparation method thereof and application, comprise zeolite and water-absorbing resins, but adopt zeolite carry out external water suction and stop blooding, just can lose efficacy after reaching water saturation, and speed anthemorrhagic speed is slow, use complex operation, there is certain limitation.

Summary of the invention

The object of this invention is to provide a kind of quick-acting haemostatic powder spray, by the effect of the astringing to arrest bleeding of Chinese medicine, make local vasoconstriction, increase platelet count, shorten the thromboplastin rise time, prevent excessive bleeding associated with exhaustion of QI, fast bleeding is given treatment to.

The invention provides a kind of quick-acting haemostatic powder spray, the raw material of Chinese medicine of following parts by weight is formulated: Radix Scutellariae 3 ~ 8 parts, Herba Agrimoniae 10 ~ 15 parts, Cortex Phellodendri 5 ~ 10 parts, Rhizoma Coptidis 3 ~ 8 parts, Radix Sophorae Tonkinensis 1 ~ 3 part, Bulbus Fritillariae Thunbergii 3 ~ 8 parts, Indigo Naturalis 3 ~ 8 parts, Borneolum Syntheticum 1 ~ 3 part, Radix Et Rhizoma Rhei 3 ~ 8 parts, Mentholum 3 ~ 8 parts, Herba Phylae Samentosea 3 ~ 8 parts, Caulis Seu Folium Euonymi Fortunei 3 ~ 8 parts, Os Draconis 3 ~ 8 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 3 ~ 8 parts, 5 ~ 10 parts, Radix Rubiae, Os Sepiae 3 ~ 8 parts, 3 ~ 5 parts, Radix Glycyrrhizae.

More preferably formulated by the raw material of Chinese medicine of following parts by weight: Radix Scutellariae 5 parts, Herba Agrimoniae 12 parts, Cortex Phellodendri 6 parts, Rhizoma Coptidis 5 parts, Radix Sophorae Tonkinensis 2 parts, Bulbus Fritillariae Thunbergii 4 parts, Indigo Naturalis 4 parts, Borneolum Syntheticum 1 part, Radix Et Rhizoma Rhei 5 parts, Mentholum 5 parts, Herba Phylae Samentosea 5 parts, Caulis Seu Folium Euonymi Fortunei 5 parts, Os Draconis 5 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 5 parts, 7 parts, Radix Rubiae, Os Sepiae 5 parts, 4 parts, Radix Glycyrrhizae.

Preparation method is for carry out according to the following steps:

(1) Radix Scutellariae, Herba Agrimoniae, Cortex Phellodendri, Rhizoma Coptidis, Radix Sophorae Tonkinensis, Bulbus Fritillariae Thunbergii, Indigo Naturalis, Radix Et Rhizoma Rhei, Mentholum, Herba Phylae Samentosea, Caulis Seu Folium Euonymi Fortunei, Os Draconis, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Rubiae part, Os Sepiae, Radix Glycyrrhizae are cleaned, dry, described bake out temperature is 85-100 DEG C, and drying time is 35-45min;

(2) medical material in the step (1) of drying and Borneolum Syntheticum are joined in pulverizer and pulverized, drainage screen 200 ~ 250 order obtains medicament, then is continued to join in pulverizer by medicament and continue to pulverize again, and drainage screen 250 ~ 300 order obtains spray mix;

(3) by spray mix as carry out in sterilization tank room temperature pressurization sterilizing, described sterilization tank temperature is 25 ~ 45 DEG C, and sterilization pressure is 2 ~ 8MPa pressure, sterilization time 1 ~ 2 hour.

(4) bottle joined the spray mix of sterilizing with shower nozzle is canned, sealing.

Pharmacology analysis:

Radix Scutellariae: bitter, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian.Have heat clearing and damp drying, removing heat from blood is antiabortive, detoxicating functions.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.

Herba Agrimoniae: property is put down, bitter in the mouth, puckery; Return stomach, liver, spleen, lung, large intestine channel.Function relieves internal heat anticancer, cooling blood for hemostasis, detumescent of healing the wounds, astringing to arrest bleeding, preventing the attack (or recurrence) of malaria, dysentery relieving, removing toxic substances; For hemoptysis, spit blood, control epistaxis and have specially good effect, malaria, de-power impairment caused by overstrain, carbuncle.

Cortex Phellodendri: bitter in the mouth, cold in nature; Return kidney, bladder, large intestine channel.Function heat clearing away, dampness, pathogenic fire purging, removing toxic substances; Cure mainly hematodiarrhoea, have loose bowels, quench one's thirst, jaundice ， flaccidity of feet with lamenness, nocturnal emission, stranguria with turbid discharge, hemorrhoid, have blood in stool, leucorrhea with red and white discharge, hectic fever due to YIN-deficiency consumptive fever, conjunctival congestion and swelling pain, aphtha of the mouth and tongue, sore swollen toxin.

Rhizoma Coptidis: bitter in the mouth, cold.Effect heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion, and toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.Modern pharmacology proves, Rhizoma Coptidis has antibacterial action, antifungic action, antivirus action, anti-ameba effect and the effect such as antiinflammatory, diarrhea.

Radix Sophorae Tonkinensis: bitter, cold; Poisonous; Return lung, stomach warp.Have heat-clearing and toxic substances removing, effect of detumescence sore-throat relieving, is usually used in fire-toxin and pents up, tonsillitis sore throat, laryngopharynx swelling and pain, gingivitis, aphtha of the mouth and tongue.

Bulbus Fritillariae Thunbergii: removing heat-phlegm, powder detoxifcation; Control cough due to pathogenic wind-heat, lung abscess sore throat, scrofula, sore swollen toxin.

Indigo Naturalis: nature and flavor are salty-cold, returns liver, lung, stomach warp.There are the effects such as heat-clearing and toxic substances removing, removing heat from blood are loose swollen, purging liver-fire, arresting convulsion.Cure mainly epidemic febrile disease intenseness of heat, macule, spit blood, spitting of blood, pharyngalgia, aphtha, pediatric epilepsy scared, skin ulcer swells, erysipelas, eczema, Cuo carbuncle, mumps, snake bite and insect sting etc.The effects such as modern pharmacological research shows, and Indigo Naturalis has antitumor, antibacterium and dermatophytes, enhancing immunity, treatment ulcer, protect the liver.

Borneolum Syntheticum: acrid in the mouth is bitter, is slightly cold; Enter the heart, Liver Channel.Delicate fragrance a surname is loose, has refreshment of having one's ideas straightened out, the loose poison of heat clearing away, effect of improving acuity of vision and removing nebula; Cure mainly calentura unconsciousness due to high fever, apoplexy syncope due to accumulation of phlegm infantile convulsion, heat-damp in summer hoodwinks key clearly, and sore throat is deaf, and aphtha tooth swells, carbuncle sore infantile malnutrition hemorrhoid, conjunctival congestion and swelling pain, pterygium.

Radix Et Rhizoma Rhei: bitter in the mouth, cold; Return spleen, stomach, large intestine, liver, pericardium channel.Effect is attacked stagnant, clearing away damp-heat, pathogenic fire purging, removing heat from blood, blood stasis dispelling, removing toxic substances; Cure mainly excess-heat constipation, the accumulation of heat feeling of stuffiness in chest, damp-heat dysentery, jaundice, gonorrhea, edema abdominal distention, dysuria, conjunctival congestion, laryngopharynx swelling and pain, aphtha of the mouth and tongue, gastropyretic vomiting, spits blood, spitting of blood, and epistaxis, has blood in stool, hematuria, blood-retention, amenorrhea, the stagnant stomachache of the stasis of blood in puerperal, lump in the abdomen, traumatic injury, pyretic toxicity carbuncle and ulcer, erysipelas, scalds.

Mentholum: antiinflammatory, pain relieving, antipruritic, optionally can stimulate the Cold receptor of human body skin or mucosa, produce sense of cold reflection and creeping chill, cause skin mucosa vasoconstriction.

Herba Phylae Samentosea: property is put down, bitter in the mouth is nontoxic.Control cough, spit blood, stranguria with blood, traumatic injury.

Caulis Seu Folium Euonymi Fortunei: bitter in the mouth, little temperature, nontoxic; Function relaxing muscles and tendons and activating QI and blood in the collateral, hemostasis repercussive; Cure mainly lumbar muscle strain, rheumatic arthralgia, spitting of blood, metrorrhagia, menoxenia, injury and bone fracture, wound hemorrhage.

Os Draconis: property sweet-puckery flavor are flat; Enter the heart, liver, kidney, large intestine channel.Function tranquillization with heavy prescription, tranquillizing the mind by relieving convulsion, arresting sweating controlling nocturnal emission with astringent drugs, hemostasis astringing intestine to stop diarrhea, promoting tissue regeneration and ulcer healing; Cure mainly infantile convulsion demented, palpitation with a distress feeling is forgetful, insomnia and dreamful sleep, spontaneous sweating, and seminal emission stranguria with turbid discharge, tell nosebleed and have blood in stool, bleeding not during menses, dysentery proctoptosis, ulcer does not close up for a long time.

The Pseudobulbus Bletillae (Rhizoma Bletillae): bitter in the mouth, sweet, puckery, cold in nature, returns lung, liver, stomach warp.There is astringing to arrest bleeding, the merit of detumescence and promoting granulation, for all cards of interior external haemorrhage and carbuncle, scald, rhagadia manus et pedis, anal fissure etc.

Radix Rubiae: effect removing heat from blood and promoting blood circulation, blood stasis dispelling, stimulates the menstrual flow; For haematemesis, epistaxis, metrostaxis, traumatic hemorrhage, amenorrhea stasis blocking, arthralgia, tumbling and swelling.Cooling blood for hemostasis, blood circulation promoting and blood stasis dispelling: this product is stopped blooding and do not stay the stasis of blood, amenorrhea stomachache, traumatic injury hemorrhage for heat syndrome.

Os Sepiae: be the inner shell of black Quarry section animal needleless crow Quarry or Golden Crow Quarry, the traditional Chinese medical science is used as hemorrhage.There is the effects such as relieving gastric hyperacidity to alleviate stomachache, hemostasis, synthetism, bone defect healing, radioprotective, antitumor, antiulcer.

Chinese medicine of the present invention, by the effect of the astringing to arrest bleeding of Chinese medicine, makes local vasoconstriction, increases platelet count, shortens the thromboplastin rise time, prevents excessive bleeding associated with exhaustion of QI, give treatment to fast to bleeding.

Outcome measure:

Effective: after using, in 15min, wound face is no longer hemorrhage, and patient vital signs is tending towards normal;

Effective: after using, in 15min, wound face is without bleeding profusely, and patient vital signs is tending towards normal gradually;

Invalid: all diseases are without improvement.

Therapeutic outcome: use to 326 bleeding patients, spray external used medicine according to amount of bleeding at wound face, effective 230 examples, account for 70.6%, and effective 95 examples, account for 29.1%, and invalid 1 example, accounts for 0.3%.

Attached several routine case is described further:

Case 1: in so-and-so, female, 50 years old, because vehicle accident causes health many places haemophilia, after wound face sprays medicine of the present invention, wound face was bled no longer in a large number in time, and through follow-up rescue, vital sign recovers normal.

Case 2: section, man, 19 years old, be wound because setting off firecrackers, and causes bleeding incessantly, and after wound face sprays medicine of the present invention, wound face is bled no longer in a large number in time, and through follow-up rescue, vital sign recovers normal.

Detailed description of the invention

Embodiment 1:

A kind of quick-acting haemostatic powder spray, the raw material of Chinese medicine of following parts by weight is formulated: Radix Scutellariae 5 parts, Herba Agrimoniae 12 parts, Cortex Phellodendri 6 parts, Rhizoma Coptidis 5 parts, Radix Sophorae Tonkinensis 2 parts, Bulbus Fritillariae Thunbergii 4 parts, Indigo Naturalis 4 parts, Borneolum Syntheticum 1 part, Radix Et Rhizoma Rhei 5 parts, Mentholum 5 parts, Herba Phylae Samentosea 5 parts, Caulis Seu Folium Euonymi Fortunei 5 parts, Os Draconis 5 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 5 parts, 7 parts, Radix Rubiae, Os Sepiae 5 parts, 4 parts, Radix Glycyrrhizae.

Preparation method is for carry out according to the following steps:

(1) Radix Scutellariae, Herba Agrimoniae, Cortex Phellodendri, Rhizoma Coptidis, Radix Sophorae Tonkinensis, Bulbus Fritillariae Thunbergii, Indigo Naturalis, Radix Et Rhizoma Rhei, Mentholum, Herba Phylae Samentosea, Caulis Seu Folium Euonymi Fortunei, Os Draconis, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Rubiae part, Os Sepiae, Radix Glycyrrhizae are cleaned, dry, described bake out temperature is 90 DEG C, and drying time is 40min;

(2) medical material in the step (1) of drying and Borneolum Syntheticum are joined in pulverizer and pulverized, drainage screen 230 order obtains medicament, then is continued to join in pulverizer by medicament and continue to pulverize again, and drainage screen 280 order obtains spray mix;

(3) by spray mix as carry out in sterilization tank room temperature pressurization sterilizing, described sterilization tank temperature is

30 DEG C, sterilization pressure is 5MPa pressure, sterilization time 1.5 hours.

Embodiment 2:

A kind of quick-acting haemostatic powder spray, the raw material of Chinese medicine of following parts by weight is formulated: Radix Scutellariae 3 parts, Herba Agrimoniae 15 parts, Cortex Phellodendri 5 parts, Rhizoma Coptidis 8 parts, Radix Sophorae Tonkinensis 1 part, Bulbus Fritillariae Thunbergii 8 parts, Indigo Naturalis 3 parts, Borneolum Syntheticum 3 parts, Radix Et Rhizoma Rhei 3 parts, Mentholum 8 parts, Herba Phylae Samentosea 3 parts, Caulis Seu Folium Euonymi Fortunei 8 parts, Os Draconis 3 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 8 parts, 5 parts, Radix Rubiae, Os Sepiae 8 parts, 3 parts, Radix Glycyrrhizae.

Preparation method is for carry out according to the following steps:

(1) Radix Scutellariae, Herba Agrimoniae, Cortex Phellodendri, Rhizoma Coptidis, Radix Sophorae Tonkinensis, Bulbus Fritillariae Thunbergii, Indigo Naturalis, Radix Et Rhizoma Rhei, Mentholum, Herba Phylae Samentosea, Caulis Seu Folium Euonymi Fortunei, Os Draconis, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Rubiae part, Os Sepiae, Radix Glycyrrhizae are cleaned, dry, described bake out temperature is 100 DEG C, and drying time is 35min;

(2) medical material in the step (1) of drying and Borneolum Syntheticum are joined in pulverizer and pulverized, drainage screen 250 order obtains medicament, then is continued to join in pulverizer by medicament and continue to pulverize again, and drainage screen 250 order obtains spray mix;

45 DEG C, sterilization pressure is 2MPa pressure, sterilization time 2 hours.

Embodiment 3:

A kind of quick-acting haemostatic powder spray, the raw material of Chinese medicine of following parts by weight is formulated: Radix Scutellariae 8 parts, Herba Agrimoniae 10 parts, Cortex Phellodendri 10 parts, Rhizoma Coptidis 3 parts, Radix Sophorae Tonkinensis 3 parts, Bulbus Fritillariae Thunbergii 3 parts, Indigo Naturalis 8 parts, Borneolum Syntheticum 1 part, Radix Et Rhizoma Rhei 8 parts, Mentholum 3 parts, Herba Phylae Samentosea 8 parts, Caulis Seu Folium Euonymi Fortunei 3 parts, Os Draconis 8 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 3 parts, 10 parts, Radix Rubiae, Os Sepiae 3 parts, 5 parts, Radix Glycyrrhizae.

Preparation method is for carry out according to the following steps:

(1) Radix Scutellariae, Herba Agrimoniae, Cortex Phellodendri, Rhizoma Coptidis, Radix Sophorae Tonkinensis, Bulbus Fritillariae Thunbergii, Indigo Naturalis, Radix Et Rhizoma Rhei, Mentholum, Herba Phylae Samentosea, Caulis Seu Folium Euonymi Fortunei, Os Draconis, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Rubiae part, Os Sepiae, Radix Glycyrrhizae are cleaned, dry, described bake out temperature is 85 DEG C, and drying time is 45min;

(2) medical material in the step (1) of drying and Borneolum Syntheticum are joined in pulverizer and pulverized, drainage screen 200 order obtains medicament, then is continued to join in pulverizer by medicament and continue to pulverize again, and drainage screen 300 order obtains spray mix;

(3) by spray mix as carry out in sterilization tank room temperature pressurization sterilizing, described sterilization tank temperature is 25 DEG C, and sterilization pressure is 8MPa pressure, sterilization time 1 hour.

Below the present invention be described in detail, the above, be only the preferred embodiment of the present invention, when not limiting the scope of the present invention, namely allly does impartial change according to the application's scope and modify, all should still belong in covering scope of the present invention.

Claims

1. a quick-acting haemostatic powder spray, is characterized in that by the raw material of Chinese medicine of following parts by weight formulated: Radix Scutellariae 3 ~ 8 parts, Herba Agrimoniae 10 ~ 15 parts, Cortex Phellodendri 5 ~ 10 parts, Rhizoma Coptidis 3 ~ 8 parts, Radix Sophorae Tonkinensis 1 ~ 3 part, Bulbus Fritillariae Thunbergii 3 ~ 8 parts, Indigo Naturalis 3 ~ 8 parts, Borneolum Syntheticum 1 ~ 3 part, Radix Et Rhizoma Rhei 3 ~ 8 parts, Mentholum 3 ~ 8 parts, Herba Phylae Samentosea 3 ~ 8 parts, Caulis Seu Folium Euonymi Fortunei 3 ~ 8 parts, Os Draconis 3 ~ 8 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 3 ~ 8 parts, 5 ~ 10 parts, Radix Rubiae, Os Sepiae 3 ~ 8 parts, 3 ~ 5 parts, Radix Glycyrrhizae.

2. a kind of quick-acting haemostatic powder spray as claimed in claim 1, is characterized in that by the raw material of Chinese medicine of following parts by weight formulated: Radix Scutellariae 5 parts, Herba Agrimoniae 12 parts, Cortex Phellodendri 6 parts, Rhizoma Coptidis 5 parts, Radix Sophorae Tonkinensis 2 parts, Bulbus Fritillariae Thunbergii 4 parts, Indigo Naturalis 4 parts, Borneolum Syntheticum 1 part, Radix Et Rhizoma Rhei 5 parts, Mentholum 5 parts, Herba Phylae Samentosea 5 parts, Caulis Seu Folium Euonymi Fortunei 5 parts, Os Draconis 5 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 5 parts, 7 parts, Radix Rubiae, Os Sepiae 5 parts, 4 parts, Radix Glycyrrhizae.