CN104491427A - Traditional Chinese medicine for treating spleen deficiency and liver stagnation type non-alcoholic fatty liver disease - Google Patents
Traditional Chinese medicine for treating spleen deficiency and liver stagnation type non-alcoholic fatty liver disease Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine for treating spleen deficiency and liver stagnation type non-alcoholic fatty liver disease. The traditional Chinese medicine is prepared from brassica narinosa, semen aesculi, Tibetan yam, artichoke, radix bupleuri, fructus rubi, radix dipsaci, radix paeoniae alba, pogonia and concha margaritifera. The traditional Chinese medicine can be clinically used for treating spleen deficiency and liver stagnation type non-alcoholic fatty liver disease.
Description
Technical field
The invention belongs to technical field of Chinese medicines, especially relate to a kind of Chinese medicine for the treatment of spleen liver depression-type non-alcoholic fatty liver disease.
Background technology
Non-alcohol fatty liver (nonalcoholicaftty liver disaese, NAFLD) refers to except caused by ethanol and other clear and definite damage liver factors, the clinical pathology syndrome being principal character with diffusivity hepatocyte Macrovesicular steatosis.Along with growth in the living standard and living-pattern preservation, the sickness rate of N A F L D rises year by year, and age of onset is tending towards rejuvenation, one of three large hepatopathys now having become harm humans health.The modal Symptoms of spleen liver depression-type non-alcoholic fatty liver disease is distending pain over the hypochondrium or dull pain, feels depressed, inappetence, limbs fatigue, light red tongue or light fat, white and thin fur or thin greasy, stringy and thready pulse or heavy carefully unable.There is no the specially good effect means for the treatment of spleen liver depression-type non-alcoholic fatty liver disease at present, the therapeutic effect of some chemicalses and safety issue are still needed and are checked further.The treatment by Chinese herbs spleen liver depression-type non-alcoholic fatty liver disease that the present invention prepares, achieves good effect.
Summary of the invention
The object of the present invention is to provide that a kind of therapeutic effect is good, effective percentage is high, Chinese medicine to the treatment spleen liver depression-type non-alcoholic fatty liver disease of human non-toxic's side effect.
The object of the present invention is achieved like this, according to Chinese medical theory, utilize the property of medicine of Chinese medicine uniqueness, adopt collapse dish, Semen Aesculi, Dioscorea deltoidea Wall.ex Griseb., Cynara scolymus L (Cyhara cardunculus.), Radix Bupleuri, Fructus Rubi, Radix Dipsaci, the Radix Paeoniae Alba, Zhu Lan, Concha Margaritifera, according to certain compatibility requirement, through being processed into.
Prepare Chinese medicine of the present invention to be made up of following raw material medicaments: dish 40-50 part of collapsing, Semen Aesculi 20-30 part, Dioscorea deltoidea Wall.ex Griseb. 20-30 part, Cynara scolymus L (Cyhara cardunculus.) 15-25 part, Radix Bupleuri 15-25 part, Fructus Rubi 15-25 part, Radix Dipsaci 15-25 part, Radix Paeoniae Alba 10-15 part, Zhu Lan 10-15 part, Concha Margaritifera 8-10 part.
Optimum weight part of raw material of Chinese medicine medicine of the present invention is: collapse dish 45 parts, Semen Aesculi 25 parts, Dioscorea deltoidea Wall.ex Griseb. 25 parts, Cynara scolymus L (Cyhara cardunculus.) 18 parts, Radix Bupleuri 18 parts, Fructus Rubi 18 parts, Radix Dipsaci 18 parts, the Radix Paeoniae Alba 12 parts, Zhu Lan 12 parts, Concha Margaritifera 9 parts.
The pharmacological action of Chinese medicine of the present invention is as follows:
Collapse dish: sweet, flat.Return liver, spleen, large intestine channel.Soothing liver and strengthening spleen, loosening bowel to relieve constipation.Clinical in incoordination between the liver and spleen, eating accumulation, gastral cavity abdomen painful abdominal mass is swollen, indigestion and loss of appetite, the diseases such as constipation.
Semen Aesculi: sweet, warm.Return liver, stomach warp.Soothing the liver, regulate the flow of vital energy, alleviating distention in middle-JIAO, pain relieving.Clinical in the breast side of body, distending pain of the breast, dysmenorrhea, the diseases such as gastric abscess.
Dioscorea deltoidea Wall.ex Griseb.: sweet, flat.Tonifying the spleen and stomach, lung benefiting kidney.Clinical in diarrhea due to hypofunction of the spleen, chronic cough of deficiency lung, emission due to deficiency of the kidney, the disease such as to quench one's thirst.
Cynara scolymus L (Cyhara cardunculus.): sweet, flat.Depressed liver-energy dispersing and function of gallbladder promoting, rushes down clearly damp and hot.Clinical in jaundice, two side of body distending pain, the diseases such as damp-heat dysentery.
Radix Bupleuri: bitter, pungent, be slightly cold, returns liver, gallbladder meridian.Evacuation is brought down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI.For stagnation of QI due to depression of the liver, pain in chest and hypochondrium.
Fructus Rubi: sweet, sour, flat.Return liver, kidney channel.The liver and the kidney tonifying, controlling nocturnal emission with astringent drugs reducing urination, improving eyesight.For impotence and premature ejaculation, emission and spermatorrhea, cold womb is infertile, and leukorrhagia is rare clearly, the diseases such as early whitening of beard and hair.
Radix Dipsaci: bitter, pungent, tepor.Return liver, kidney channel.Invigorating the liver and kidney, bone and muscle strengthening, blood circulation regulating, only metrorrhagia.For aching pain in waist and back, damage muscle labor bone, metrorrhagia, seminal emission, is with inferior disease.
The Radix Paeoniae Alba: bitter, sour, is slightly cold, returns liver, spleen channel.Nourish blood and seek, relieving spasm to stop pain, yin fluid astringing suppressing the hyperactive liver.Cure mainly blood deficiency cold and heat, epigastric pain, have a headache dizzy.
Zhu Lan: sweet, flat.Heat-clearing and toxic substances removing.For diseases such as hepatitis, cholecystitis, carbuncle sore tumefacting virus.
Concha Margaritifera: salty, cold, GUIXIN, Liver Channel.Suppressing the hyperactive liver and subsiding YANG, liver heat removing and eyesight improving, tranquilizing mind.For insomnia, the malaise of palpitating with fear.
Non-alcoholic fatty liver disease belongs to multiple and frequently-occurring disease, and dietary structure changes, and the food intake of higher fatty acid property is too much main Primary factors.The harm of primary disease, more and more causes the attention of doctor and numerous patients.Control protopathy because of, improve dietary structure, increase sports, health invigorating becomes the task of top priority.Non-alcoholic fatty liver disease is modern medicine name of disease, motherland's medical science there is no this name of disease, according to its clinical symptoms, belongs to the categories such as Chinese medicine " long-pending card " " hypochondriac pain " " feeling of fullness " " expectorant is turbid " for the patient fallen ill, use Chinese medicine Comprehensive Treatment, curative effect is affirmative.Coryza Treated by Syndrome Differentiation primary disease, according to the negative and positive cold and heat and asthenia and sthenia situation of human body, plus-minus uses, and how can cure or relief of symptoms.The present invention is collapsed vegetables or greens liver spleen, for monarch drug, Semen Aesculi is soothing the liver, regulate the flow of vital energy, alleviating distention in middle-JIAO, pain relieving, Dioscorea deltoidea Wall.ex Griseb. tonifying the spleen and stomach, lung benefiting kidney are ministerial drug, Cynara scolymus L (Cyhara cardunculus.) depressed liver-energy dispersing and function of gallbladder promoting, Radix Bupleuri evacuation is brought down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI, Fructus Rubi the liver and the kidney tonifying, Radix Dipsaci invigorating the liver and kidney, blood circulation regulating, Radix Paeoniae Alba relieving spasm to stop pain, yin fluid astringing suppressing the hyperactive liver, Zhu Lan heat-clearing and toxic substances removing, Concha Margaritifera suppressing the hyperactive liver and subsiding YANG, liver heat removing and eyesight improving, tranquillizing and allaying excitement, compatibility uses, and plays invigorating the spleen and benefiting QI, dispersing the depressed liver-QI for alleviating pain altogether, the merit of promoting flow of QI and blood, tranquillizing and allaying excitement, reaches the object for the treatment of spleen liver depression-type non-alcoholic fatty liver disease.
Chinese medicine of the present invention is used in 2007 to 2012 the routine patients of clinical observation spleen liver depression-type non-alcoholic fatty liver disease disease 67, and clinical report is as follows:
1, physical data
In 67 routine patients, women 42 example, male 25 example, minimum 36 years old of age, maximum 45 years old, 35.6 years old mean age.
2, diagnostic criteria
With reference to " Chinese medical disease Standardization of diagnosis and curative effect ":
1. without history of drinking history or drink and amount to amount of alcohol, male is < 40g weekly.2. except, viral hepatitis, drug-induced liver disease, full gastrointestinal nutrition, hepatolenticular degeneration etc. can cause the specified disease of fatty liver.3., except primary disease clinical manifestation, weak, nonspecific symptom and the sign such as dyspepsia, dull pain in liver, hepatosplenomegaly can be accompanied.4. can there is the overweight and (or) Abdominal obesity of weight, fasting glucose increases, the metabolism syndrome associated change such as blood fat disorder, hypertension.5. serum transaminase and GGT level can have and gently increase (< 5 times of Upper Limit of Normal Values) to mild or moderate, usually increase to master with ALT.6. liver imageology performance meets diffusivity fatty liver imaging diagnosis main points.7. liver biopsy Histological change meets the pathological diagnosis main points of fatty liver.Above 7 possess 1. ~ 6. or the 7. can determine diagnosis any one of item 5. item and the.
Spleen liver depression-type non-alcoholic fatty liver disease clinical symptoms: distending pain over the hypochondrium or dull pain, feel depressed, inappetence, limbs fatigue, light red tongue or light fat, white and thin fur or thin greasy, stringy and thready pulse or heavy carefully unable.
3, Therapeutic Method
3.1 prescriptions: collapse dish 45g, Semen Aesculi 25g, Dioscorea deltoidea Wall.ex Griseb. 25g, Cynara scolymus L (Cyhara cardunculus.) 18g, Radix Bupleuri 18g, Fructus Rubi 18g, Radix Dipsaci 18g, Radix Paeoniae Alba 12g, Zhu Lan 12g, Concha Margaritifera 9g.
3.2 preparation methoies: said medicine routinely technique makes decoction.
3.3 instructions of taking: each 1 dose, every day 2 times 30 days was 1 course for the treatment of.
3.4 observation index: the change of record patient symptom, sign and diet, weight situation.Row ultrasound diagnosis liver, gallbladder, pancreas, spleen before and after treatment, venous blood samples detects serum lipids, liver function level, comprises T-CHOL (TC), triacylglycerol (TG), alanine aminotransferase (ALT), aspartate amino transferase (AST).
4, therapeutic outcome:
4.1 with reference to " Chinese medical disease Standardization of diagnosis and curative effect ":
Clinical cure: clinical symptoms and sign disappear, liver B ultrasonic or CT examination, lab testing recover normal;
Effective: clinical symptoms and sign are obviously improved, liver B ultrasonic or CT examination, take a turn for the better obviously, and the indices of lab testing declines more than 40%;
Do not heal: clinical symptoms and sign are improved not obvious, liver B ultrasonic or CT examination treatment front and back are without significant change, and the indices of lab testing is without obvious decline.
4.2 results: in 67 routine patients, clinical cure 35 example (52%), effective 25 examples (37%), do not heal 7 examples (11%), and total effective rate is 89%.
5, model case
5.1 Wang, man, 45 years old, liver function shows glutamate pyruvate transaminase (ALT) 74U/L, glutamic oxaloacetic transaminase, GOT (AST) 46U/L, glutamyl transpeptidase (r-GGT): 57U/L, blood fat: cholesterol 5.61mmol/l, triglyceride 5.6mmol/L.CT shows: severe fatty liver.Take medicine of the present invention, treat 1 course for the treatment of, all diseases alleviate, and continue to take 3 courses for the treatment of, and check liver function, blood fat are all normal, and CT shows: liver and gall spleen pancreas shows no obvious abnormalities, recovery from illness.Follow up a case by regular visits to after half a year without recurrence.
5.2 Zhao, female, 39 years old, once did the inspections such as liver function, blood fat, color ultrasound, CT, was diagnosed as spleen liver depression-type non-alcoholic fatty liver disease.Blood fat is higher, and transaminase is high.Examine and see that red tongue tongue is white, stringy and thready pulse.Take medicine of the present invention, every day 1 dose, after 1 course for the treatment of, all diseases alleviate, and continue to take 1 course for the treatment of, and check liver function, blood fat are all normal, and CT shows: liver and gall spleen pancreas shows no obvious abnormalities, recovery from illness.Follow up a case by regular visits to after half a year without recurrence.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further illustrated, and this embodiment following does not only limit the present invention for illustration of the present invention.
Embodiment 1, a kind of Chinese medicine for the treatment of spleen liver depression-type non-alcoholic fatty liver disease, it is made up of following raw material medicaments: collapse dish 40g, Semen Aesculi 20g, Dioscorea deltoidea Wall.ex Griseb. 20g, Cynara scolymus L (Cyhara cardunculus.) 15g, Radix Bupleuri 15g, Fructus Rubi 15g, Radix Dipsaci 15g, Radix Paeoniae Alba 10g, Zhu Lan 10g, Concha Margaritifera 8g.
Embodiment 2, a kind of Chinese medicine for the treatment of spleen liver depression-type non-alcoholic fatty liver disease, it is made up of following raw material medicaments: collapse dish 45g, Semen Aesculi 25g, Dioscorea deltoidea Wall.ex Griseb. 25g, Cynara scolymus L (Cyhara cardunculus.) 18g, Radix Bupleuri 18g, Fructus Rubi 18g, Radix Dipsaci 18g, Radix Paeoniae Alba 12g, Zhu Lan 12g, Concha Margaritifera 9g.
Embodiment 3, a kind of Chinese medicine for the treatment of spleen liver depression-type non-alcoholic fatty liver disease, it is made up of following raw material medicaments: collapse dish 50g, Semen Aesculi 30g, Dioscorea deltoidea Wall.ex Griseb. 30g, Cynara scolymus L (Cyhara cardunculus.) 25g, Radix Bupleuri 25g, Fructus Rubi 25g, Radix Dipsaci 25g, Radix Paeoniae Alba 15g, Zhu Lan 15g, Concha Margaritifera 10g.
Claims (2)
1. treat a Chinese medicine for spleen liver depression-type non-alcoholic fatty liver disease, it is characterized in that comprising following crude drug:
To collapse dish 40-50 part, Semen Aesculi 20-30 part, Dioscorea deltoidea Wall.ex Griseb. 20-30 part, Cynara scolymus L (Cyhara cardunculus.) 15-25 part, Radix Bupleuri 15-25 part, Fructus Rubi 15-25 part, Radix Dipsaci 15-25 part, Radix Paeoniae Alba 10-15 part, Zhu Lan 10-15 part, Concha Margaritifera 8-10 part.
2. Chinese medicine according to claim 1, is characterized in that comprising following crude drug:
Collapse dish 45 parts, Semen Aesculi 25 parts, Dioscorea deltoidea Wall.ex Griseb. 25 parts, Cynara scolymus L (Cyhara cardunculus.) 18 parts, Radix Bupleuri 18 parts, Fructus Rubi 18 parts, Radix Dipsaci 18 parts, the Radix Paeoniae Alba 12 parts, Zhu Lan 12 parts, Concha Margaritifera 9 parts.
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