CN104491394A

CN104491394A - Medicine for treating diabetes and preparation method thereof

Info

Publication number: CN104491394A
Application number: CN201510002438.8A
Authority: CN
Inventors: 李锦才; 吴易强
Original assignee: GUANGDONG WEIDUO BIOTECHNOLOGY Co Ltd
Current assignee: GUANGDONG WEIDUO BIOTECHNOLOGY Co Ltd
Priority date: 2015-01-05
Filing date: 2015-01-05
Publication date: 2015-04-08

Abstract

The invention discloses a medicine for treating diabetes and a preparation method thereof, relates to the technical field of biological medicine and aims at providing a medicine for controlling and reducing blood glucose and preventing the occurrence and development of diabetic complications. The medicine comprises the active ingredients prepared from the following raw materials in parts by weight: 20-220 parts of poria with hostwood, 5-50 parts of rhizoma cyperi, 10-100 parts of euonymus alatus, 5-100 parts of rhizoma alismatis, 8-20 parts of herba periliae, 6-30 parts of radix paeoniae alba, 8-60 parts of herba leonuri, 1-8 parts of agilawood, 2-15 parts of medicated leaven, 2-10 parts of radix ophiopogonis, 2-15 parts of herba artemisiae capillariae and 8-80 parts of lychee seed. The medicine is economical and practical.

Description

A kind of medicine for the treatment of diabetes and preparation method thereof

Technical field

The present invention relates to biomedicine technical field, particularly a kind of for controlling and reducing the blood glucose in diabetics body, and medicine preventing complication and preparation method thereof simultaneously.

Background technology

Diabetes (diabetes) act on body by various virulence factors such as inherited genetic factors, immunologic function disorder, infected by microbes, free radical, Nervous and Mental Factors to cause hypoinsulinism, insulin resistant (Insulin Resistance, the a series of metabolism disorder syndrome such as sugar, protein, fat, water and eletrolytes caused such as IR), be main feature clinically with hyperglycemia, the performance such as polyuria, polydipsia, polyphagia can appear in model case, become thin, i.e. " three-many-one-little " symptom.

Definitely or relative deficiency, and target tissue cell reduces insulin sensitivity diabetics insulin secretion, thus causes a series of dysbolismus such as sugar, albumen, fat, water and eletrolytes.Diabetes are diseases of the easy overheap of glucose in a kind of blood, are a kind of diseases of glucose in urine.When the glucose level in a human blood raises, diabetes onset, can destroy the tissue of health, causes blind and neural damage.

A lot of hypertensive patient clinically, particularly obesity-related hypertension patient is often with diabetes, and diabetes are also more with hypertension.Therefore, both are referred to as homology disease.Its main cause is as follows:

Common gene may be there are in diabetes and hypertension; Diabetic blood vessel is responsive to the angiotensin with boosting; Diabetes easily cause kidney damage, blood pressure can be made to raise after compromised kidneys evil.In addition, diabetes patient increases due to blood glucose, and blood viscosity increases, and blood vessel wall is impaired, and vascular resistance increases, and easily causes hypertension.It can thus be appreciated that hypertension and diabetes are all relevant with hyperlipidemia, therefore, preventing and treating diabetes and hypertension all should blood fat reducing simultaneously.

The therapeutic goal of diabetes patient controls blood glucose, blood fat, body weight, makes it to reach desirable level, prevent generation and the development of complication.Old-aged diabetic often has serious cardiovascular and neural complication, and the complication such as ketoacidosis, hyperosmotic nonketonic acidosis, lactic acidosis.

Diabetes divide type 1 diabetes (type 1 diabetes) and type 2 diabetes mellitus (type 2 diabetes) and gestational diabetes (gestational diabetes).Wherein type 1 diabetes is multiple is born in teenager, and its insulin secretion lacks, and must rely on insulinize and sustain life.Type 2 diabetes mellitus is more common in after 30 years old, old people, and the secretory volume of its insulin is not low even also higher, the cause of disease mainly body to insulin insensitivity (i.e. insulin resistant).Gestational diabetes (gestational diabetes) is the insulin resistant coming from cell, but its insulin resistant is because the hormone (hormone) of pregnancy women secretion causes.Gestational diabetes spontaneous recovery after secretion usually.

Insulin is blood sugar lowering hormone unique in the health of human pancreas β emiocytosis.Insulin resistant refers to that in body, surrounding tissue reduces the sensitivity of insulin, organizes insulin insensitivity, to insulin, peripheral tissues such as muscle, fat promote that the effect of glucose uptake there occurs opposing.

Research finds insulin resistant ubiquity in type 2 diabetes mellitus, almost accounts for more than 90%.

The appearance of complication is seldom had in after making a definite diagnosis 5 years of type 1 diabetes patient.

Type 2 diabetes mellitus patient just had chronic complicating diseases to occur before making a definite diagnosis.According to statistics, have the type 2 diabetes mellitus of 50% newly diagnosis to there is one or more chronic complicating diseases, some patient just finds to suffer from diabetes because of complication.Diabetic complication shows as: retinopathy, nephropathy and the disease such as neurological disorder and arteriosclerosis, and glucose superfluous in blood corrodes the disastrous effect of systemic organs and tissue thereof gradually.

Therefore, the Drug therapy of diabetes should, for its cause of disease, be focused on improving insulin resistant, and the protection to Pancreatic beta cells function, must select the medicine that can improve insulin resistant.If this drug main euglycemic agent, diabetics is made to obtain timely and effective and fundamentally data, the generation of the chronic complicating diseases that prevents diabetes and development.

Euglycemic agent can increase the sensitivity of body to own insulin, make the insulin of self proud " resurrection " and play one's part to the full, so just can enable blood glucose again absorb by body tissue cell and utilize, blood glucose is declined, reaching the object with controlling blood glucose all sidedly steady in a long-term, making human body can enjoy the insulin of self secretion for a long time.

The survey data display several years ago of the total institute of diabetes study of department of Chinese medicine institute of China, the diabetics number of China is more than more than 5,000 ten thousand, account for 1/5th of world's diabetic population sum, prevalence occupies second place of the world, and the speed of minimum 3000 people increases with every day, increase above 1,200,000 people every year, predict to China's diabetes number in 2015 and will surge to 100,000,000 people.Diabetics mortality rate is very high, often dead ahead of time owing to being difficult to cure.

Prevention, treatment, the generation controlling diabetes and radical cure diabetes, be conducive to the quality of life of improving people.

In general, the people of 90 percent suffers from diabetes, and its life will shorten about 10 years, and, also do not effect a radical cure the specific drug of diabetes at present in the world, treat diabetes with Traditional chinese medicine medicament, there is not only economy but also practical effect.

Chinese medicine is discussed glycosuria etiology and pathogenesis and is thought: mainly because the ferritic deficiency of YIN, the five internal organs are weak and eating and drinking without temperance, surfeit delicious food, disorder of emotion, labor for excessively, and cause deficiency of kidney-YIN, lung dryness of the stomach heat; Pathogenesis emphasis is that the deficiency of YIN is scorching, and is this with the deficiency of YIN, and scorching is mark; With the passing of time disease prolongs, deficiency of YIN affecting YANG, deficiency in both YIN and YANG; The deficiency of YIN is scorching, and consumption Tianjin liquid that burns makes blood viscous; Deficiency of YIN affecting YANG, yang deficiency cold coagulation, also can cause sun in congestion.

1, the reason of the ferritic deficiency of YIN is caused to have:

(1) congenital defect: " Ling Shu Miraculous Pivot or Divine Axis five becomes a section " is said: " all soft weak person of the five internal organs, kind sick diseases due to endogenous heat of ZANG FU organs ".Refer to caused by parent fetal cultivation deficiency.

(2) day after tomorrow, loss was excessive: infringement as evil in poison, the cloudy Tianjin of loss.

(3) source is changed not enough: the internal organs as changed raw cloudy Tianjin are impaired, and cloudy having no way of of essence is raw, as " medical secrets of official quench one's thirst door " is said: " quench one's thirst, former its starts, and caused by this then suffers from a deficiency of the kidney, often sending out is that urine is extremely sweet.

(4) male-female relationship imbalance between internal organs, cause cloudy damage too much eventually, sun must be economized partially, Yang Taisheng then causes " disappear ".

2, cause eating and drinking without temperance, the reason of obesity have:

(1) the long-term sweet and refreshing savoury of surfeit, makes the transportation capabilities of spleen damage, and stagnant in stomach, intrinsic heat dryness-transformation, impairment of YIN consumes Tianjin, and more make in stomach scorching, rapid digestion of food and polyorexia increases the weight of.

(2) because of fat people's excessive phlegm, stagnation of phlegm heat-transformation, also can consume cloudy Tianjin, and YIN fluid being insufficient can be changed again raw scorching, scorching again must impairment of YIN.Vicious cycle like this and diabetes occurs.

3, disorder of emotion, depression of liver-QI.

Control due to long-term feelings and do not relax, stasis heat-dissipating, change bath impairment of YIN; Or because of rage, cause liver to lose bar and reach; Mechanism of qi blocks, also can heat-dissipating dryness-transformation, and the cloudy Tianjin of the bright lung stomach that can disappear, cause lung dryness of the stomach heat, and thirsty polydipsia occurs, rapid digestion of food and polyorexia.With the passing of time the deficiency of YIN scorching, must cause deficiency of both QI and YIN.Deficiency of YIN affecting YANG and occur deficiency of QI and declination of YANG phenomenon, because lung, stomach, kidney three are through the cloudy deficiency of vital energy, the deficiency of both YIN and YANG disease that yang-energy is occurred by holding back.

4, diseases caused by exogenous pathogenic factor six climate exopathogens, the evil infringement of poison.

Diseases caused by exogenous pathogenic factor six climate exopathogens, invade loose cream (pancreas) in dryness-fire wind heat poison heresy, take up internal organs, dryness-transformation impairment of body fluid, also diabetes can occur.Exogenous triple diabetes and diseases caused by exogenous pathogenic factor six climate exopathogens, the diabetes caused by the evil infringement of poison.

Summary of the invention

The object of the invention is to use Chinese and western medical science theoretical, provide a kind of Chinese medicine for the treatment of diabetes and preparation method thereof, this Chinese medicine has control and reduces blood glucose and prevent the generation of diabetic complication and the effect of development.

For achieving the above object, the invention provides a kind of like this medicine for the treatment of diabetes, comprise effective ingredient, it is characterized in that, described effective ingredient is made up of the raw material of following weight portion: Poria cum Radix Pini 20 ~ 220, Rhizoma Cyperi 5 ~ 50, Ramulus Euonymi 10 ~ 100, Rhizoma Alismatis 5 ~ 100, Folium Perillae 8 ~ 20, the Radix Paeoniae Alba 6 ~ 30, Herba Leonuri 8 ~ 60, Lignum Aquilariae Resinatum 1 ~ 8, Massa Medicata Fermentata 2 ~ 15, Radix Ophiopogonis 2 ~ 10, Herba Artemisiae Scopariae 2 ~ 15, Semen Litchi 8 ~ 80.

Preferably, described effective ingredient is made up of the raw material of following weight portion: Poria cum Radix Pini 20 ~ 50, Rhizoma Cyperi 5 ~ 15, Ramulus Euonymi 10 ~ 35, Rhizoma Alismatis 5 ~ 40, Folium Perillae 8 ~ 15, the Radix Paeoniae Alba 6 ~ 20, Herba Leonuri 8 ~ 15, Lignum Aquilariae Resinatum 1 ~ 5, Massa Medicata Fermentata 2 ~ 8, Radix Ophiopogonis 2 ~ 10, Herba Artemisiae Scopariae 2 ~ 12, Semen Litchi 8 ~ 30.

More preferably, described effective ingredient is made up of the raw material of following weight portion: Poria cum Radix Pini 20 ~ 40, Rhizoma Cyperi 5 ~ 10, Ramulus Euonymi 10 ~ 20, Rhizoma Alismatis 5 ~ 20, Folium Perillae 8 ~ 10, the Radix Paeoniae Alba 6 ~ 10, Herba Leonuri 8 ~ 10, Lignum Aquilariae Resinatum 1 ~ 2, Massa Medicata Fermentata 2 ~ 6, Radix Ophiopogonis 2 ~ 10, Herba Artemisiae Scopariae 2 ~ 12, Semen Litchi 8 ~ 20.

Preferably, described medicine is tablet or capsule.

Present invention also offers the preparation method of the medicine of above-mentioned treatment diabetes, it is characterized in that comprising the following steps:

(1) Indian Bread With Hostwood is produced: Poria cum Radix Pini extracted with the alcohol heating reflux that the percent by volume of 5 times of weight is 68%, extracting liquid filtering, dry powder;

(2) Nutgrass Galingale Rhizome is produced: by the soak by water 2 times of Rhizoma Cyperi 10-12 times of weight, each 1.5 hours, merge twice decoction liquor, dry powder;

(3) produce Ramulus Euonymi powder: by the soak by water 2 times of Ramulus Euonymi 6-8 times weight, 2 hours first times, second time 1.5 hours, filter, merge twice filtrate, dry powder;

(4) produce Oriental Waterplantain Rhizome: the boiled water of Rhizoma Alismatis 12-16 times of weight is soaked 30 minutes, filters to get filtrate for subsequent use, then with the soak by water 1 hour of 15-30 times of weight, filter to get filtrate for subsequent use, merge twice filtrate, dry powder;

(5) decocted 1 ~ 2 hour at 60 ~ 100 DEG C by the water of several raw medicinal materials of remainder by 8 ~ 12 times of weight, filter after decocting, filtrate first carries out high speed centrifugation, then uses membrane filtration, and being finally evaporated to relative density at 60 DEG C is the clear paste of 0.8 ~ 1.5; Powder is obtained after gained clear paste thing is spray-dried.

Preferably, before producing powder, by all raw material pulverizing.

Preferably, temperature during concentrating under reduced pressure is 60 ~ 100 DEG C, vacuum is 0.08 ~ 0.09MPa.

Preferably, temperature during spraying dry is 75 ~ 100 DEG C, and physiochemical forces is 0.06 ~ 0.09MPa, and spray velocity is 30 ~ 40kg/h.

Preferably; this preparation method is further comprising the steps of: after the extract powder mix homogeneously of all raw materials; add adjuvant carboxymethyl cellulose, dextrin, remix water spray evenly and regulate humidity; then granulate with granulator; add adjuvant Pulvis Talci, magnesium stearate again, dry, granulate; carry out tabletting with tablet machine, obtain tablet.

beneficial effect:

Compared with prior art, medicine provided by the invention is to the analysis of the etiology and pathogenesis of diabetes according to Chinese and western medical science, for treating diabetes requirement, from Chinese medicine nature and flavor, Gui Jing, function with cure mainly to start with and develop, this Chinese medicine has control and reduces blood glucose and prevent the generation of diabetic complication and the effect of development, not only economy but also practical.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is described in further detail, and following examples are explanation of the invention, and the present invention is not limited to following examples.

Embodiment 1

Pharmaceutical formulation is as follows:

Poria cum Radix Pini 20g, Rhizoma Cyperi 5g, Ramulus Euonymi 10g, Rhizoma Alismatis 5g, Folium Perillae 8g, Radix Paeoniae Alba 6g, Herba Leonuri 8g, Lignum Aquilariae Resinatum 1g, Massa Medicata Fermentata 2g, Radix Ophiopogonis 2g, Herba Artemisiae Scopariae 2g, Semen Litchi 8g;

Clinical practice:

Usage: decocting drinks its juice;

Hu, man, after within 65 years old, being diagnosed as hyperglycemia, feel dizzy head sink, ante prandium cardiopalmus, weak, perspire, facial hectic fever.Chemical examination blood glucose: 9.5mmol/L on an empty stomach, early two hours blood glucose 15.0 mmol/L after the meal, ante prandium blood glucose 11.0 mmol/L, patient is in hyperglycemia environment for a long time, histiocyte adapts to hyperglycemia, once blood glucose declines rapidly, patients' neural's system can not adapt to quickly completely, just there will be slight dizzy dizzy.Along with blood glucose declines further, also can bring out sympathetic activation, occur cardiopalmus, weak, perspire, facial hectic fever.In fact, above-mentioned symptom is all the adaptation response of body, and after a period of time, symptom can fade away.Take the medicine of above-mentioned formula after one month, blood glucose is down to 9.8 mmol/L, then eats and within one month, be down to 7.0 mmol/L, rear and eaten 20 days, and blood glucose check no abnormality seen, hypoglycemic effect is very remarkable.

Embodiment 2

Pharmaceutical formulation is as follows:

Poria cum Radix Pini 40g, Rhizoma Cyperi 10g, Ramulus Euonymi 20g, Rhizoma Alismatis 16g, Folium Perillae 10g, Radix Paeoniae Alba 10g, Herba Leonuri 10g, Lignum Aquilariae Resinatum 2g, Massa Medicata Fermentata 6g, Radix Ophiopogonis 10g, Herba Artemisiae Scopariae 12g, Semen Litchi 10g;

Clinical practice:

Usage: decocting drinks its juice;

Holt, man, 43 years old, diabetes more than 5 years.Patient is fasting glucose (FBG) 16 mmol/L when health check-up in 2007, so far all non-systematic treating always.Symptom is shown in dizziness, bitter taste, malaise, and sweating is few, and biped is swollen, edema, and urine yellow skin matter is glutinous foam.Tongue fur BOHUANG is greasy, and stringy pulse is number slightly.Be diagnosed as mild fatty liver during patient's health check-up in 2013, now transfer severe fatty liver to: hypertension history 8 years, non-systems axiol-ogy and treatment, patient is addicted to drink, and has Diabetes family history.Height 180cm, body weight 88kg, BMI=27. test in laboratory FBG17 mmol/L, after the meal 2 hours blood glucoses (PBG2h) 28.25 mmol/L. glycolated hemoglobin 12.3%.Glucose in urine 5.6 mg/d1, ketoboidies 2.5mg/d1.Blood fat: glutamate pyruvate transaminase 43U/L, triglyceride 6.58 mmol/L, cholesterol 6.22 mmol/L, low density lipoprotein, LDL 3.72 mmol/L.Dialectical genus syndrome of liver-stomach heat, controls with dissipating depression of QI clearing stomach.After patient takes the medicine 45 doses of above-mentioned formula, bitter taste disappears, and malaise improves about 80%, only dizzy when nervous.Edema of lower limbs disappears, and swells and alleviates 90%, and urine color depth is yellow, bubble face reduces about 70%, and weight loss is about 10kg.FBG4.8 mmol/L，PBG2h 5.6 mmol/L。Glycolated hemoglobin 8.9%.Take medicine again after 20 doses, blood glucose is down to 3.1, and blood fat check no abnormality seen, hypoglycemic effect is stablized at present.

Embodiment 3

Pharmaceutical formulation is as follows:

Poria cum Radix Pini 40g, Rhizoma Cyperi 10g, Ramulus Euonymi 20g, Rhizoma Alismatis 20g, Folium Perillae 10g, Radix Paeoniae Alba 6g, Herba Leonuri 10g, Lignum Aquilariae Resinatum 2g, Massa Medicata Fermentata 4g, Radix Ophiopogonis 3g, Herba Artemisiae Scopariae 3g, Semen Litchi 20g;

Clinical practice:

Usage: decocting drinks its juice;

Liu Guocheng, man, 58 years old.Within 2012, check, blood glucose is 36 mmol/L, and glucose in urine is 26 mmol/L, complication: retinal hemorrhage, both legs fester, more than area 10cm.After inspection, start the medicine taking above-mentioned formula, after treating half a year, blood glucose reduces to 6.0 mmol/L, and glucose in urine is 10.6 mmol/L, and complication disappears, now rehabilitation, and current blood sugar level is stablized.

Embodiment 4

Pharmaceutical formulation is as follows:

Poria cum Radix Pini's 50 parts of Folium Perillae 15 parts of Massa Medicata Fermentatas 8 parts

Rhizoma Cyperi 15 portions of Radix Paeoniae Albas 20 parts of Radix Ophiopogonis 10 parts

Ramulus Euonymi 35 parts of Herba Leonuris 15 portions of Herba Artemisiae Scopariaes 10 parts

Rhizoma Alismatis 20 parts of Semen Litchis 30 portions of Lignum Aquilariae Resinatum 5 parts

According to following steps, the medicine of above-mentioned formula is made capsule:

(1) produce Indian Bread With Hostwood: 68% alcohol heating reflux getting 5 times of weight Poria cum Radix Pinis Yu extracts 3 times, each 1 hour, merge extractive liquid, filter, dry as powder;

(2) produce Nutgrass Galingale Rhizome: add Rhizoma Cyperi 12 times of weight water, decoct 2 times, each 1.5 hours, merge and boil liquid twice, dry as powder;

(3) produce Ramulus Euonymi powder: cleaned by fresh Ramulus Euonymi, add 8 times of weight in Ramulus Euonymi soak by water, 2 hours first times, second time 1.5 hours, filter, merge twice filtrate, dry as powder;

(4) produce Oriental Waterplantain Rhizome: pulverize, soak 30 minutes, filter to get filtrate for subsequent use, then decoct 1 hour by 15-30 times of weight water, filter to get filtrate for subsequent use with 12 times of weight in the boiled water of Rhizoma Alismatis, twice gained filtrate is dry must powder;

(5) cleaned by several raw medicinal materials of remainder, be cut into coarse grain, the water adding 8 ~ 12 times of weight decocts 1 ~ 2 hour at 60 ~ 100 DEG C, and decoction limit, limit is stirred; Decoct after filter, filtrate first carries out high speed centrifugation, then uses membrane filtration, and finally under the condition of temperature 60 ~ 100 DEG C, vacuum 0.08 ~ 0.09MPa, being evaporated to relative density is 0.8 ~ 1.5(60 DEG C) clear paste; Obtain powder after gained clear paste thing is spray-dried, spray drying temperature is 75 ~ 100 DEG C, and physiochemical forces is 0.06 ~ 0.09MPa, and spray velocity is 30 ~ 40kg/h;

(6) the powder mix homogeneously of above-mentioned various raw medicinal material will obtained, incapsulates.

Embodiment 5

Pharmaceutical formulation is as follows:

Poria cum Radix Pini's 28 parts of Folium Perillae 10 portions of Lignum Aquilariae Resinatum 5 parts

Rhizoma Cyperi 12 portions of Radix Paeoniae Albas 10 parts of Massa Medicata Fermentatas 8 parts

Ramulus Euonymi 20 parts of Herba Leonuris 10 parts of Radix Ophiopogonis 10 parts

Rhizoma Alismatis 40 parts of Semen Litchis 15 portions of Herba Artemisiae Scopariaes 15 parts

According to following step, the medicine of above-mentioned formula is made tablet:

(2) produce Nutgrass Galingale Rhizome: add Rhizoma Cyperi 10 times of weight water, decoct 2 times, each 1.5 hours, merge and boil liquid twice, dry as powder;

(3) produce Ramulus Euonymi powder: cleaned by fresh Ramulus Euonymi, add 6 times of weight in Ramulus Euonymi soak by water, decoct 2 times, 2 hours first times, second time 1.5 hours, filter, merge twice filtrate, dry as powder;

(4) produce Oriental Waterplantain Rhizome: pulverize, soak 30 minutes, filter to get filtrate for subsequent use with 16 times of weight in the boiled water of Rhizoma Alismatis, then with the soak by water 1 hour of 15-30 times of weight, filter to get filtrate for subsequent use, twice gained filtrate is dry must powder;

(6) the powder mix homogeneously of above-mentioned various raw medicinal material will obtained, adds adjuvant carboxymethyl cellulose, dextrin; after mix homogeneously, by 100 mesh sieves, then spray the distilled water of medicine gross weight 4-5%; put into batch mixer to mix, then with after water spray adjustment humidity, granulate with granulator; add adjuvant Pulvis Talci again, magnesium stearate, dry; granulate, carries out tabletting, after tablet makes with tablet machine; dry, enter coating conventional program after oven dry, be packaged into finished product as required.

Claims

1. treat the medicine of diabetes for one kind, comprise effective ingredient, it is characterized in that, described effective ingredient is made up of the raw material of following weight portion: Poria cum Radix Pini 20 ~ 220, Rhizoma Cyperi 5 ~ 50, Ramulus Euonymi 10 ~ 100, Rhizoma Alismatis 5 ~ 100, Folium Perillae 8 ~ 20, the Radix Paeoniae Alba 6 ~ 30, Herba Leonuri 8 ~ 60, Lignum Aquilariae Resinatum 1 ~ 8, Massa Medicata Fermentata 2 ~ 15, Radix Ophiopogonis 2 ~ 10, Herba Artemisiae Scopariae 2 ~ 15, Semen Litchi 8 ~ 80.

2. the medicine for the treatment of diabetes according to claim 1, is characterized in that: described effective ingredient is made up of the raw material of following weight portion: Poria cum Radix Pini 20 ~ 50, Rhizoma Cyperi 5 ~ 15, Ramulus Euonymi 10 ~ 35, Rhizoma Alismatis 5 ~ 40, Folium Perillae 8 ~ 15, the Radix Paeoniae Alba 6 ~ 20, Herba Leonuri 8 ~ 15, Lignum Aquilariae Resinatum 1 ~ 5, Massa Medicata Fermentata 2 ~ 8, Radix Ophiopogonis 2 ~ 10, Herba Artemisiae Scopariae 2 ~ 12, Semen Litchi 8 ~ 30.

3. the medicine for the treatment of diabetes according to claim 2, is characterized in that: described effective ingredient is made up of the raw material of following weight portion: Poria cum Radix Pini 20 ~ 40, Rhizoma Cyperi 5 ~ 10, Ramulus Euonymi 10 ~ 20, Rhizoma Alismatis 5 ~ 20, Folium Perillae 8 ~ 10, the Radix Paeoniae Alba 6 ~ 10, Herba Leonuri 8 ~ 10, Lignum Aquilariae Resinatum 1 ~ 2, Massa Medicata Fermentata 2 ~ 6, Radix Ophiopogonis 2 ~ 10, Herba Artemisiae Scopariae 2 ~ 12, Semen Litchi 8 ~ 20.

4. the medicine of the treatment diabetes according to claim 1,2 or 3, is characterized in that: described medicine is tablet or capsule.

5. the preparation method of the medicine for the treatment of diabetes according to claim 4, is characterized in that comprising the following steps:

6. preparation method according to claim 5, is characterized in that: before producing powder, by all raw material pulverizing.

7. preparation method according to claim 5, is characterized in that: temperature during concentrating under reduced pressure is 60 ~ 100 DEG C, vacuum is 0.08 ~ 0.09MPa.

8. preparation method according to claim 5, is characterized in that: temperature during spraying dry is 75 ~ 100 DEG C, and physiochemical forces is 0.06 ~ 0.09MPa, and spray velocity is 30 ~ 40kg/h.

9. the preparation method according to claim 5 to 8 any one; it is characterized in that, further comprising the steps of: after the extract powder mix homogeneously of all raw materials, to add adjuvant carboxymethyl cellulose; dextrin; remix water spray evenly and regulate humidity, then granulate with granulator, then add adjuvant Pulvis Talci, magnesium stearate; dry; granulate, carries out tabletting with tablet machine, obtains tablet.