CN104491223A - Traditional Chinese medicine composition for treating rhinitis - Google Patents
Traditional Chinese medicine composition for treating rhinitis Download PDFInfo
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- CN104491223A CN104491223A CN201410786799.1A CN201410786799A CN104491223A CN 104491223 A CN104491223 A CN 104491223A CN 201410786799 A CN201410786799 A CN 201410786799A CN 104491223 A CN104491223 A CN 104491223A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
- A61K36/575—Magnolia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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Abstract
The invention relates to a traditional Chinese medicine composition for treating rhinitis. The composition is mainly prepared from the following raw materials: radix paeoniae alba, fructus xanthii, ligusticum wallichii, licorice root, violet magnolia, rhizoma bolbostemmae, Sichuan belamcanda sinensis, radix angelicae and radices sileris. The medicine composition disclosed by the invention has a good treatment effect on the rhinitis caused by various causes.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of rhinitis, belong to technical field of Chinese medicines.
Background technology
Rhinitis, refers to that some regions in nasal cavity are upset and the inflammation produced.The typical symptom of rhinitis is usually expressed as rhinorrhea.Acute rhinitis, caused by actute infection, is commonly called as cold or flu.Cardinal symptom is nasal obstruction and secretions increase, is in early days clear water sample tears, after become coctum nasal mucus.Chronic rhinitis is common frequently-occurring disease, is developed by acute rhinitis, and with merging antibacterial secondary infection, treat thorough not relevant with recurrent exerbation, is nasal membrane and submucosal chronic inflammatory disease.
The morbidity of rhinitis is comparatively general in teenager, and current Therapeutic Method is divided into western medical treatment and Chinese traditional treatment two class.The former mainly refers to chemotherapy, as shunk the medicine of nose bleeding pipe if ephedrine, Loratadine are as cetirizine etc., and steroid hormone spray nasal preparation, these chemicalses all have side effect in various degree, and due to the cause of disease of chronic rhinitis complicated, in fact using of these medicines be difficult to fundamentally solve chronic rhinitis recurrent exerbation, a cureless difficult problem.In the treatment of rhinitis, the traditional tcm therapy of China is often proved to be has special curative effect.
Summary of the invention
For prior art Problems existing, the object of this invention is to provide a kind of Chinese medicine composition effectively treating rhinitis.
The technical solution adopted in the present invention is as follows:
A kind of Chinese medicine composition for the treatment of rhinitis, it is characterized in that, this Chinese medicine composition is made up of according to weight proportion following raw materials according medicine: Radix Paeoniae Alba 10-15 part, Fructus Xanthii 5-10 part, Rhizoma Chuanxiong 5-10 part, Radix Glycyrrhizae 20-25 part, Flos Magnoliae 5-10 part, Rhizoma Bolbostematis 10-15 part, Rhizoma Belamcandae 5-10 part, Radix Angelicae Dahuricae 5-10 part, Radix Saposhnikoviae 15-20 part.
As further preferred technical scheme, described Chinese medicine composition is made up of according to weight proportion following raw materials according medicine: the Radix Paeoniae Alba 15 parts, Fructus Xanthii 10 parts, Rhizoma Chuanxiong 5 parts, 25 parts, Radix Glycyrrhizae, Flos Magnoliae 10 parts, Rhizoma Bolbostematis 12 parts, Rhizoma Belamcandae 5 parts, the Radix Angelicae Dahuricae 8 parts, Radix Saposhnikoviae 20 parts.
This Chinese medicine composition is prepared from by following method: take each composition Chinese crude drug by proportioning, add water and decoct extraction together, merges and decoct extracting solution, filters, concentrated, centrifugal, dry, obtained dry extract.
Described Chinese medicine composition can be used for preparing any conventional oral dosage form, comprises tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, sucks agent, granule, electuary, pill, powder etc.
Pharmacodynamic experiment shows, the use of above-mentioned Chinese medicine composition significantly improves the symptom of rhinitis models mice, and effectively inhibits the propagation of mouse spleen lymphocyte, this demonstrate that Chinese medicine composition of the present invention has the remarkable efficacy for the treatment of rhinitis really.
Detailed description of the invention
Each medical material described in following embodiment is through processed such as clean system, cutting, the process of preparing Chinese medicine, pulverizing, and before feeding intake, through qualification, each herbal medicine material object conforms to title, and quality meets state-promulgated pharmacopoeia standard (concrete Med Mat Appreciation method performs with reference to standards of pharmacopoeia)
Embodiment 1
Take Radix Paeoniae Alba 100g, Fructus Xanthii 50g, Rhizoma Chuanxiong 50g, Radix Glycyrrhizae 200g, Flos Magnoliae 50g, Rhizoma Bolbostematis 100g, Rhizoma Belamcandae 50g, Radix Angelicae Dahuricae 50g, Radix Saposhnikoviae 150g, add water and decoct extraction together: add water 10L, decoct 2 hours; By decoction extracting liquid filtering, be concentrated into 20
orelative density during C is 1.059; Under 3000rpm rotating speed centrifugal 5 minutes; 80
oc spraying dry, obtains dry extract.
Embodiment 2
Take Radix Paeoniae Alba 150g, Fructus Xanthii 100g, Rhizoma Chuanxiong 100g, Radix Glycyrrhizae 250g, Flos Magnoliae 100g, Rhizoma Bolbostematis 150g, Rhizoma Belamcandae 100g, Radix Angelicae Dahuricae 100g, Radix Saposhnikoviae 200g, add water and decoct extraction together: add water 10L, decoct 2 hours; By decoction extracting liquid filtering, be concentrated into 20
orelative density during C is 1.059; Under 3000rpm rotating speed centrifugal 5 minutes; 80
oc spraying dry, obtains dry extract.
Embodiment 3
Take Radix Paeoniae Alba 150g, Fructus Xanthii 100g, Rhizoma Chuanxiong 50g, Radix Glycyrrhizae 250g, Flos Magnoliae 100g, Rhizoma Bolbostematis 120g, Rhizoma Belamcandae 50g, Radix Angelicae Dahuricae 80g, Radix Saposhnikoviae 200g, add water and decoct extraction together: add water 10L, decoct 2 hours; By decoction extracting liquid filtering, be concentrated into 20
orelative density during C is 1.059; Under 3000rpm rotating speed centrifugal 5 minutes; 80
oc spraying dry, obtains dry extract.Said preparation is used for ensuing pharmacodynamic experiment.
Embodiment 4 pharmacodynamic experiment
One, Behaviors survey
Laboratory animal used is specific pathogen free level mice in healthy male 6 week age 20, and body weight 18 ~ 22g before experiment, is provided by Medical University Of Anhui's Experimental Animal Center; Room temperature is raised, free illumination and diet.The modeling method of rhinitis models mice is: make it sensitization in first day lumbar injection ovalbumin 100 μ g and gel aluminum hydroxide mixed liquor 0.3mL, within 8th day and the 15th day, use the same method and strengthen sensitization 2 times, give 4% ovalbumin normal saline solution 20 μ L collunarium 22-28 days every days and excite.
Within 29th day, put to death by model mice, asepticly get spleen and shred, be separated splenocyte, by PBS solution, isolated cell washed twice with density－gradient centrifuga－tion method, with RPMI1640 culture fluid resuspension, Trypan Blue counts, and viable count is greater than 97%.Cell quantity is adjusted to 5 × 10
6/ mL, every hole 100 μ L is inoculated in 96 well culture plates, is placed on 5%CO
2, 37
ocultivate in C incubator.
Experiment is divided into blank group, administration group, and often group is six porocytes.Add above-mentioned Chinese medicine composition 10g to administration group, blank group does not add.Cell continues cultivation 24,48h and 72h, stops cultivating the front every hole of 4h and adds CCK-8 solution 10 μ L, be determined at the optical density value at 450nm place after hatching 4h by microplate reader, and according to following formulae discovery Chinese medicine composition to the proliferation inhibition rate of cell.Proliferation inhibition rate R=(1-administration group OD/ blank group OD) × 100%.
The proliferation inhibition rate R result of each group of cell is as shown in table 1.
The measurement result of mice dead time respectively organized by table 1
| Group | 24h R value | 48h R value | 72h R value |
| Matched group | ND | ND | ND |
| Administration group | 0.431±0.602 | 0.445±0.482 | 0.399±0.457 |
As can be seen from Table 1, depression effect has to a certain degree been there is in the spleen lymphocyte proliferation of rhinitis models mice under the process of Chinese medicine composition described in the application, this shows that this Chinese medicine composition effectively can alleviate the inflammatory reaction of rhinitis models mice, and it should have the potential therapeutical effect to rhinitis symptom.
Claims (2)
1. be used for the treatment of a Chinese medicine composition for rhinitis, it is characterized in that, this Chinese medicine composition adopts following raw materials according medicine to combine: the Radix Paeoniae Alba, Fructus Xanthii, Rhizoma Chuanxiong, Radix Glycyrrhizae and other material medicines.
2. Chinese medicine composition according to claim 1, it is characterized in that, this Chinese medicine composition is made up of according to weight proportion following raw materials according medicine: Radix Paeoniae Alba 10-15 part, Fructus Xanthii 5-10 part, Rhizoma Chuanxiong 5-10 part, Radix Glycyrrhizae 20-25 part, Flos Magnoliae 5-10 part, Rhizoma Bolbostematis 10-15 part, Rhizoma Belamcandae 5-10 part, Radix Angelicae Dahuricae 5-10 part, Radix Saposhnikoviae 15-20 part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410786799.1A CN104491223A (en) | 2014-12-18 | 2014-12-18 | Traditional Chinese medicine composition for treating rhinitis |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410786799.1A CN104491223A (en) | 2014-12-18 | 2014-12-18 | Traditional Chinese medicine composition for treating rhinitis |
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| Publication Number | Publication Date |
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| CN104491223A true CN104491223A (en) | 2015-04-08 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201410786799.1A Pending CN104491223A (en) | 2014-12-18 | 2014-12-18 | Traditional Chinese medicine composition for treating rhinitis |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000212094A (en) * | 1998-11-18 | 2000-08-02 | Takeda Chem Ind Ltd | Pharmaceutical preparation for oral cavity |
| CN1424065A (en) * | 2002-12-20 | 2003-06-18 | 唐宗园 | Medicine for nasal obstruction |
-
2014
- 2014-12-18 CN CN201410786799.1A patent/CN104491223A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000212094A (en) * | 1998-11-18 | 2000-08-02 | Takeda Chem Ind Ltd | Pharmaceutical preparation for oral cavity |
| CN1424065A (en) * | 2002-12-20 | 2003-06-18 | 唐宗园 | Medicine for nasal obstruction |
Non-Patent Citations (2)
| Title |
|---|
| 常宏艳: "超声雾化并口服中药治疗过敏性鼻炎的疗效观察", 《辽宁中医杂志》 * |
| 徐汝德: "《常见病效验方荟萃》", 28 February 2013 * |
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Application publication date: 20150408 |